liu.seSök publikationer i DiVA
Ändra sökning
Avgränsa sökresultatet
2345678 201 - 250 av 119932
RefereraExporteraLänk till träfflistan
Permanent länk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Träffar per sida
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sortering
  • Standard (Relevans)
  • Författare A-Ö
  • Författare Ö-A
  • Titel A-Ö
  • Titel Ö-A
  • Publikationstyp A-Ö
  • Publikationstyp Ö-A
  • Äldst först
  • Nyast först
  • Skapad (Äldst först)
  • Skapad (Nyast först)
  • Senast uppdaterad (Äldst först)
  • Senast uppdaterad (Nyast först)
  • Disputationsdatum (tidigaste först)
  • Disputationsdatum (senaste först)
  • Standard (Relevans)
  • Författare A-Ö
  • Författare Ö-A
  • Titel A-Ö
  • Titel Ö-A
  • Publikationstyp A-Ö
  • Publikationstyp Ö-A
  • Äldst först
  • Nyast först
  • Skapad (Äldst först)
  • Skapad (Nyast först)
  • Senast uppdaterad (Äldst först)
  • Senast uppdaterad (Nyast först)
  • Disputationsdatum (tidigaste först)
  • Disputationsdatum (senaste först)
Markera
Maxantalet träffar du kan exportera från sökgränssnittet är 250. Vid större uttag använd dig av utsökningar.
  • 201.
    Abdollahi Sani, Negar
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    Robertsson, Mats
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
    Cooper, Philip
    De La Rue Plc, Overton, Hampshire, UK .
    Wang, Xin
    Acreo AB, Norrköping, Sweden.
    Svensson, Magnus
    Acreo AB, Norrköping, Sweden.
    Andersson Ersman, Peter
    Acreo AB, Norrköping, Sweden.
    Norberg, Petronella
    Acreo AB, Norrköping, Sweden.
    Nilsson, Marie
    Acreo AB, Norrköping, Sweden.
    Nilsson, David
    Acreo AB, Norrköping, Sweden.
    Liu, Xianjie
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Ytors Fysik och Kemi. Linköpings universitet, Tekniska högskolan.
    Hesselbom, Hjalmar
    Hesselbom Innovation and Development HB, Huddinge, Sweden .
    Akesso, Laurent
    De La Rue Plc, Overton, Hampshire, UK .
    Fahlman, Mats
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Ytors Fysik och Kemi. Linköpings universitet, Tekniska högskolan.
    Crispin, Xavier
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    Engquist, Isak
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    Berggren, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan. Acreo AB, Norrköping, Sweden.
    Gustafsson, Goran
    Acreo AB, Norrköping, Sweden.
    All-printed diode operating at 1.6 GHz2014Ingår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 111, nr 33, s. 11943-11948Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Printed electronics are considered for wireless electronic tags and sensors within the future Internet-of-things (IoT) concept. As a consequence of the low charge carrier mobility of present printable organic and inorganic semiconductors, the operational frequency of printed rectifiers is not high enough to enable direct communication and powering between mobile phones and printed e-tags. Here, we report an all-printed diode operating up to 1.6 GHz. The device, based on two stacked layers of Si and NbSi2 particles, is manufactured on a flexible substrate at low temperature and in ambient atmosphere. The high charge carrier mobility of the Si microparticles allows device operation to occur in the charge injection-limited regime. The asymmetry of the oxide layers in the resulting device stack leads to rectification of tunneling current. Printed diodes were combined with antennas and electrochromic displays to form an all-printed e-tag. The harvested signal from a Global System for Mobile Communications mobile phone was used to update the display. Our findings demonstrate a new communication pathway for printed electronics within IoT applications.

    Ladda ner fulltext (pdf)
    fulltext
  • 202.
    Abdollahi Sani, Negar
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Wang, Xin
    Acreo Swedish ICT AB, Sweden.
    Granberg, Hjalmar
    INNVENTIA AB, Sweden.
    Andersson Ersman, Peter
    Acreo Swedish ICT AB, Sweden.
    Crispin, Xavier
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Dyreklev, Peter
    Acreo Swedish ICT AB, Sweden.
    Engquist, Isak
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Gustafsson, Göran
    Acreo Swedish ICT AB, Sweden.
    Berggren, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Flexible Lamination-Fabricated Ultra-High Frequency Diodes Based on Self-Supporting Semiconducting Composite Film of Silicon Micro-Particles and Nano-Fibrillated Cellulose2016Ingår i: Scientific Reports, E-ISSN 2045-2322, Vol. 6, nr 28921Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Low cost and flexible devices such as wearable electronics, e-labels and distributed sensors will make the future "internet of things" viable. To power and communicate with such systems, high frequency rectifiers are crucial components. We present a simple method to manufacture flexible diodes, operating at GHz frequencies, based on self-adhesive composite films of silicon micro-particles (Si-mu Ps) and glycerol dispersed in nanofibrillated cellulose (NFC). NFC, Si-mu Ps and glycerol are mixed in a water suspension, forming a self-supporting nanocellulose-silicon composite film after drying. This film is cut and laminated between a flexible pre-patterned Al bottom electrode and a conductive Ni-coated carbon tape top contact. A Schottky junction is established between the Al electrode and the Si-mu Ps. The resulting flexible diodes show current levels on the order of mA for an area of 2 mm(2), a current rectification ratio up to 4 x 10(3) between 1 and 2 V bias and a cut-off frequency of 1.8 GHz. Energy harvesting experiments have been demonstrated using resistors as the load at 900 MHz and 1.8 GHz. The diode stack can be delaminated away from the Al electrode and then later on be transferred and reconfigured to another substrate. This provides us with reconfigurable GHz-operating diode circuits.

    Ladda ner fulltext (pdf)
    fulltext
  • 203.
    Abdolmajid Ahmad, Bookan
    Linköpings universitet, Institutionen för datavetenskap. Linköpings universitet, Tekniska högskolan.
    Programmering av generativ konst i C# .Net2014Självständigt arbete på grundnivå (kandidatexamen), 180 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Detta examensarbete utfördes på IDA (Institutionen för datavetenskap) vid Linköpings universitet. 

    Syftet med det här examensarbetet var att utveckla ett program som skulle skapa förutsättningar för generativ konst med hjälp av MyPaint som är ett digitalt rit/målarverktyg. Metoden gick ut på att registrera vad användaren skapat för komponenter, dvs. musinteraktioner och kortkommandon, och därefter använda dem algoritmiskt.

    Examensarbetet resulterades i ett program (SharpArt), som fångar musinteraktioner samt simulerar tangentbordstryckningar (kortkommandon) från och till Mypaint, vilket i sin tur skapar komponenter som används algoritmiskt. Programmet kan även positionera objektet på canvasen enligt det önskade koordinatvärdet.

    Ladda ner fulltext (pdf)
    fulltext
  • 204.
    Abdul Aziz Hasan Ali, Aamir
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Kommunikations- och transportsystem. Linköpings universitet, Tekniska högskolan.
    Shahzad, Muhammad Adil
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Kommunikations- och transportsystem. Linköpings universitet, Tekniska högskolan.
    A Joint Subcarrier/Power allocation Scheme for OFDMA-based Cellular Networks2012Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The assignment of this master thesis consists of initiating power, subcarrier allocation in a dynamic FFR based scheme designed for multi-cell OFDMA networks and to enhance the throughput of all center users in bandwidth hungry borrower cells (overloaded cells) which was previously degraded by original FFR3 scheme as a result of partitioning of system bandwidth into center and edge bands respectively. The method uses band borrowing to compensate center user’s throughput loss in a semi and fully overloaded system. The scheme uses dynamic programming method (0/1 knapsack problem) to bargain an edge band on various power levels and tends to check the best combination (power and sub-carrier) which the system can utilize while still maintaining acceptable throughput loss for the users at the edge of the neighboring cell (lender cell).

    The algorithm consists of generating a borrowing request to neighboring cells for utilizing their edge bands by the overloaded borrower cell if their average center user throughput reaches below a minimum threshold value set in the system. The borrowing method uses 0/1 knapsack problem to capture an edge band based on limiting factors of total cost in average throughput losses by neighbors (Ci) and Un (tolerable mean user edge user throughput loss by lending cell). While solving knapsack problem the lender (neighbors) will check Ci and Un before granting the right to use its edge band. The later stage requires reducing subcarrier power level in order to utilize the lenders edge band using "soft borrower" mode. The borrowed sub-carriers will be activated take power from the original center band sub-carriers of the overloaded cell by taking into account the interference between the lender and the borrower. In case of negative (0) reply from the lender cell after the first request, multiple requests are generated at reduce power level at every step to order to acquire more bands. If a neighbor has band borrowing requests from multiple overloaded base stations, the band will be granted to the one which gives minimal loss in terms of throughput to the lender cell.

    The simulation results are analyzed w.r.t reuse-1 and FFR3 scheme of a multi cell regular and irregular scenarios comprising of lightly to heavily overloaded cells with various subcarrier allocation patterns. An overhead and time assessment is also presented between borrower and lender cells. Simulation results show an increase of 60% in center user’s throughput w.r.t original FFR3 scheme with an acceptable loss of 18% at the edges in complex overloaded scenarios while the overall system throughout increases by 35%.

    Ladda ner fulltext (pdf)
    fulltext
  • 205.
    Abdul Nazar, Mohamed
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Design of a Gysel Combiner at 100 MHz2019Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    This thesis relates to the design and implementation of a Gysel power combiner consisting of two input ports. The design is implemented using discrete (lumped) components over the conventional transmission line architecture and operates at 100 MHz. Because of the high power requirements for the power combiner, special attention is given to the power handling capabilities of the lumped elements and the other components involved. Simulations of an S-parameter of Gysel power combiner are performed using the Advanced Design System (ADS) from Keysight Technologies. The final design of two-way Gysel power combiner using PCB toroidal inductor was implemented, simulated and optimized at centre frequency of 100 MHz. Satisfactory results were obtained in terms of Insertion loss, Return loss and Port Isolation.

    Ladda ner fulltext (pdf)
    Design of a Gysel Combiner at 100 MHz
  • 206.
    Abdulahad, Bassam
    et al.
    Linköpings universitet, Institutionen för datavetenskap.
    Lounis, Georgios
    Linköpings universitet, Institutionen för datavetenskap.
    A user interface for the ontology merging tool SAMBO2004Självständigt arbete på grundnivå (yrkesexamen)Studentuppsats
    Abstract [en]

    Ontologies have become an important tool for representing data in a structured manner. Merging ontologies allows for the creation of ontologies that later can be composed into larger ontologies as well as for recognizing patterns and similarities between ontologies. Ontologies are being used nowadays in many areas, including bioinformatics. In this thesis, we present a desktop version of SAMBO, a system for merging ontologies that are represented in the languages OWL and DAML+OIL. The system has been developed in the programming language JAVA with JDK (Java Development Kit) 1.4.2. The user can open a file locally or from the network and can merge ontologies using suggestions generated by the SAMBO algorithm. SAMBO provides a user-friendly graphical interface, which guides the user through the merging process.

    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 207.
    Abdulhamidova, Nurangez
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling.
    The European Union-Central Asia: in the light of the New Strategy2009Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Central Asia is a region strategically located on the crossroads of the two continents. The region is represented by five states (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan) with different level of economic development and with the population amounting to over 60 million people. The region is rich in energy resources, represented by oil, gas, coal and hydropower resources.

    The thesis analyses, assesses and scrutinises one of the topical issues of the contemporary international relations - cooperation between the European Union and Central Asian states before and after adoption in June 2007 of the ‘European Union and Central Asia: Strategy for a New Partnership’, an important political document in the history of relations between the two parties.

    The new stage of cooperation is analysed more comprehensively accentuating priorities set in the Strategy. Analysis of the current state of affairs is conducted concerning some important issues of the Strategy related to regional cooperation between Central Asian states, such as integrated water management and development of hydro-energy system, issues of diversification of hydrocarbons supply routes from the region to Europe and provision of energy security, etc.

    Issues of cooperation between the European Union and Tajikistan are analysed as a case study. State of affairs between some of the European Union member-states and Central Asian countries is characterised.

    The thesis also scrutinises other regional/international actors engaged in cooperation with Central Asia (such as China, Russia, the US, Shanghai Cooperation Organisation, etc.) and their potential for interaction with the European Union for more effective joint solution of the problems existing in the region is assessed.

    In the conclusion, development of cooperation between the European Union and Central Asian states is scrutinised, the problems and their possible solutions in this regard are analysed, and the recommendations for increasing effectiveness of cooperation between the two parties are presented.

    The European Union’s foreign policy in Central Asia is interpreted from perspective of the theories of international relations namely neorealism, neoliberalism and constructivism in the end of every chapter.

    Ladda ner fulltext (pdf)
    The European Union-Central Asia : in the light of the New Strategy
    Ladda ner (pdf)
    COVER01
  • 208.
    Abdulhamidova, Nurangez
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling.
    The European Union-Central Asia: in the light of the New Strategy2009Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Central Asia is a region strategically located at the crossroads of the two continents: Asia and Europe. The region is represented by five states (Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan) with different level of economic development and with the population amounting to over 60 million people. The region is rich in energy resources represented by oil, gas, coal and water resources.

    The thesis analyses, assesses and scrutinises one of the topical issues of the contemporary international relations - cooperation between the European Union and Central Asian states before and after adoption in June 2007 of the ‘European Union and Central Asia: Strategy for a New Partnership’,  an important political document in the history of relations between the two parties.

    The new stage of cooperation is analysed more comprehensively accentuating priorities set in the Strategy. Analysis of the current state of affairs is conducted concerning some important issues of the Strategy related to regional cooperation between Central Asian states, such as integrated water management and development of hydro-energy system, issues of diversification of hydrocarbons supply routes from the region to Europe and provision of energy security, etc.

    Issues of cooperation between the European Union and Tajikistan are analysed as a case study. State of affairs between the Central Asian states and the European Union Member States actively cooperating with these countries is characterised.

    The thesis also scrutinises other regional/international actors engaged in cooperation with Central Asia (such as China, Russia, the US, Shanghai Cooperation Organisation, etc.) and their potential for interaction with the European Union for more effective joint solution of the problems existing in the region is assessed.

    In the conclusion, development of cooperation between the European Union and Central Asian states is scrutinised, the problems and their possible solutions in this regard are analysed, and the recommendations for increasing effectiveness of cooperation between the two parties are presented.

    The European Union’s policy in Central Asia is interpreted from perspective of the theories of international relations namely neorealism, neoliberalism and constructivism in the research.

    Ladda ner fulltext (pdf)
    The European Union-Central Asia: in the light of the New Strategy
  • 209. Beställ onlineKöp publikationen >>
    Abdulla, Afrah
    Linköpings universitet, Institutionen för beteendevetenskap och lärande. Linköpings universitet, Utbildningsvetenskap. Department of Social and Behavioural Studies, Division of Social Pedagogy and Sociology, Högskolan Väst, Trollhättan, Sweden.
    Readiness or resistance?: Newly arrived adult migrants' experiences, meaning making, and learning in Sweden2017Doktorsavhandling, monografi (Övrigt vetenskapligt)
    Abstract [sv]

    Denna studie handlar om nyanlända vuxna migranters meningsskapande och lärande i det svenska samhället under deras tvååriga introduktionsperiod, efter att de har fått uppehållstillstånd. Jag har specifikt studerat arabisktalande vuxnas meningsskapande och lärande, genom observationer och enskilda djupintervjuer med 12 nyanlända. Introduktionsperioden består främst av tre s.k. etableringsinsatser; kursen i samhällsorientering, svenska för invandrare (SFI) samt olika arbetsrelaterade och arbetsfrämjande insatser, såsom praktik på olika arbetsplatser.

    Resultatet visar att etablering handlar om att forma de vuxna nyanlända till ”goda” medborgare, genom etableringsinsatserna, bl.a. i samhällsorienteringskursen, som regleras genom policydokumenten, och som s.a.s. tillhandahåller mening för de nyanlända. Den ”goda” medborgaren har vissa specifika kännetecken, vilka, i grova drag, är att han eller hon är självständig (och förespråkar individualitet), fri, jämlikhetstänkande, sekulariserad, laglydig (vilket inkluderar ärlig), ansvarsfull, och en ”god” förälder. Dessa karaktärsdrag kommer på olika sätt till uttryck i samhällsorienteringskursen, exempelvis genom kursmaterialet. Det svenska samhället framställs då också som något eftersträvansvärt, och skilt från det som antyds vara ”arabiska” värderingar och tänkesätt. Föreställningen om den ”goda” medborgaren verka syfta till att konstruera den vuxna nyanländas (och dennas familjs) identitet, något som många av studiens respondenter gör motstånd mot.

    Vad gäller migrantens nya erfarenheter, är det exempelvis de som migranten har fått genom kontakt med Arbetsförmedlingen som påverkar meningsskapandet i det nya samhället. Den mening som de flesta av respondenterna har gjort om Arbetsförmedlingens insatser för dem är att denna myndighet enbart erbjuder dem ”förpaketerade” lösningar, och inte tillhandahåller den hjälp eller det stöd som de behöver. Även erfarenheter som migranten gör i samhällsorienteringskursen, samt den mening som ”gamla” migranter förmedlar till honom eller henne, spelar roll för hur vederbörande skapar mening om Sverige och svenskar, och om sin nya livssituation. Dessutom har det visat sig att det är de erfarenheter som den vuxna har blivit socialiserad genom, samt de som han eller hon har fått genom utbildning eller arbete i ursprungslandet, som påverkar migrantens meningsskapande i Sverige. Det är främst värderingar som är knutna till barnuppfostran och religion som leder till en viss förståelse och konstruktion av ens nya liv. Dessa värderingar leder också, när de stöts mot de värderingar som ingår i föreställningen om den ”goda” medborgaren, antingen till ett motstånd mot eller en beredvillighet inför det meningsgivande som ingår i den ”goda” medborgaren.

    Ladda ner fulltext (pdf)
    Readiness or resistance?: Newly arrived adult migrants' experiences, meaning making, and learning in Sweden
    Ladda ner (pdf)
    omslag
    Ladda ner (png)
    presentationsbild
  • 210.
    Abdulla, Afrah
    et al.
    Linköpings universitet, Institutionen för beteendevetenskap och lärande. Linköpings universitet, Filosofiska fakulteten.
    Risenfors, Signild
    Högskolan Väst.
    Kursen samhällsorientering för nyanlända: mobilisering och integration för deltagare2013Ingår i: Gemenskaper: socialpedagogiska perspektiv / [ed] Lisbeth Eriksson, Gunilla Nilsson, Lars A. Svensson, Göteborg: Daidalos, 2013, s. 117-138Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • 211.
    Abdulla, Ariyan
    et al.
    Linköpings universitet, Matematiska institutionen, Optimeringslära. Linköpings universitet, Tekniska fakulteten.
    Andersson, Erik
    Linköpings universitet, Matematiska institutionen, Optimeringslära. Linköpings universitet, Tekniska fakulteten.
    Heuristiska algoritmer för schemaläggning i real-tidssystem med hänsyn till data beroenden2018Självständigt arbete på grundnivå (kandidatexamen), 10,5 poäng / 16 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The schedule for the jobs in a real-time system can have a huge impact on how the system behave. Since real-time systems are common in safety applications it is important that the scheduling is done in a valid way. Furthermore, one can enhance the performance of the applications by minimizing data latency and jitter. A challenge is that jobs in real-time systems usually have complex constraints making it too time consuming to minimize data latency and jitter to optimality. The purpose of this report is to investigate the possibility of creating high quality schedules using heuristics, with the goal to keep the computational time under one minute. This will be done by comparing three different algorithms that will be used on real scheduling instances provided by the company Arcticus. The first algorithm is a greedy heuristic, the second one a local search and the third one is a metaheuristic, simulated annealing. The results indicate that the data latency can be reduced whilst keeping the computational time below one minute.

    Ladda ner fulltext (pdf)
    fulltext
  • 212.
    Abdulla, Parosh Aziz
    et al.
    Department of Information Technology, Uppsala University, Sweden.
    Atig, Mohamed Faouzi
    Department of Information Technology, Uppsala University, Sweden.
    Chen, Yu-Fang
    Institute of Information Science, Academia Sinica, Taiwan.
    Holik, Lukas
    Faculty of Information Technology, Brno University of Technology, Czech Republic.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    Rümmer, Philipp
    Department of Information Technology, Uppsala University, Sweden.
    Stenman, Jari
    Department of Information Technology, Uppsala University, Sweden.
    String Constraints for Verification2014Ingår i: 26th International Conference on Computer Aided Verification (CAV 2014), Vienna, Austria, Jul. 9-12, 2014., Berlin: Springer, 2014, s. 150-166Konferensbidrag (Refereegranskat)
    Abstract [en]

    We present a decision procedure for a logic that combines (i) word equations over string variables denoting words of arbitrary lengths, together with (ii) constraints on the length of words, and on (iii) the regular languages to which words belong. Decidability of this general logic is still open. Our procedure is sound for the general logic, and a decision procedure for a particularly rich fragment that restricts the form in which word equations are written. In contrast to many existing procedures, our method does not make assumptions about the maximum length of words. We have developed a prototypical implementation of our decision procedure, and integrated it into a CEGAR-based model checker for the analysis of programs encoded as Horn clauses. Our tool is able to automatically establish the correctness of several programs that are beyond the reach of existing methods.

  • 213.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Atig, Mohamed Faouzi
    Uppsala University, Sweden.
    Chen, Yu-Fang
    Academia Sinica, Taiwan.
    Leonardsson, Carl
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    Automatic fence insertion in integer programs via predicate abstraction2012Ingår i: Static Analysis: 19th International Symposium, SAS 2012, Deauville, France, September 11-13, 2012. Proceedings / [ed] Antoine Miné, David Schmidt, Springer Berlin/Heidelberg, 2012, s. 164-180Konferensbidrag (Refereegranskat)
    Abstract [en]

    We propose an automatic fence insertion and verification framework for concurrent programs running under relaxed memory. Unlike previous approaches to this problem, which allow only variables of finite domain, we target programs with (unbounded) integer variables. The problem is difficult because it has two different sources of infiniteness: unbounded store buffers and unbounded integer variables. Our framework consists of three main components: (1) a finite abstraction technique for the store buffers, (2) a finite abstraction technique for the integer variables, and (3) a counterexample guided abstraction refinement loop of the model obtained from the combination of the two abstraction techniques. We have implemented a prototype based on the framework and run it successfully on all standard benchmarks together with several challenging examples that are beyond the applicability of existing methods.

  • 214.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Atig, Mohamed Faouzi
    Uppsala University, Sweden.
    Chen, Yu-Fang
    Academia Sinica, Taiwan.
    Leonardsson, Carl
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, ESLAB - Laboratoriet för inbyggda system. Linköpings universitet, Tekniska högskolan.
    Counter-Example Guided Fence Insertion under TSO2012Ingår i: TACAS 2012, Berlin, Heidelberg: Springer , 2012Konferensbidrag (Refereegranskat)
    Abstract [en]

    We give a sound and complete fence insertion procedure for concurrentfinite-state programs running under the classical TSO memory model. Thismodel allows “write to read” relaxation corresponding to the addition of an unboundedstore buffer between each processor and the main memory. We introducea novel machine model, called the Single-Buffer (SB) semantics, and show thatthe reachability problem for a program under TSO can be reduced to the reachabilityproblem under SB. We present a simple and effective backward reachabilityanalysis algorithm for the latter, and propose a counter-example guided fence insertionprocedure. The procedure is augmented by a placement constraint thatallows the user to choose places inside the program where fences may be inserted.For a given placement constraint, we automatically infer all minimal setsof fences that ensure correctness. We have implemented a prototype and run itsuccessfully on all standard benchmarks together with several challenging examplesthat are beyond the applicability of existing methods.

  • 215.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Atig, Mohamed Faouzi
    Uppsala University, Sweden.
    Chen, Yu-Fang
    Academia Sinica, Taiwan.
    Leonardsson, Carl
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    Memorax, a Precise and Sound Tool for Automatic Fence Insertion under TSO2013Ingår i: Tools and Algorithms for the Construction and Analysis of Systems: 19th International Conference, TACAS 2013, Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2013, Rome, Italy, March 16-24, 2013. Proceedings, Springer Berlin/Heidelberg, 2013, s. 530-536Konferensbidrag (Refereegranskat)
    Abstract [en]

    We introduce MEMORAX, a tool for the verification of control state reachability (i.e., safety properties) of concurrent programs manipulating finite range and integer variables and running on top of weak memory models. The verification task is non-trivial as it involves exploring state spaces of arbitrary or even infinite sizes. Even for programs that only manipulate finite range variables, the sizes of the store buffers could grow unboundedly, and hence the state spaces that need to be explored could be of infinite size. In addition, MEMORAX in- corporates an interpolation based CEGAR loop to make possible the verification of control state reachability for concurrent programs involving integer variables. The reachability procedure is used to automatically compute possible memory fence placements that guarantee the unreachability of bad control states under TSO. In fact, for programs only involving finite range variables and running on TSO, the fence insertion functionality is complete, i.e., it will find all minimal sets of memory fence placements (minimal in the sense that removing any fence would result in the reachability of the bad control states). This makes MEMORAX the first freely available, open source, push-button verification and fence insertion tool for programs running under TSO with integer variables.

  • 216.
    Abdulla, Parosh Aziz
    et al.
    Uppsala Univ, Sweden.
    Atig, Mohamed Faouzi
    Uppsala Univ, Sweden.
    Chen, Yu-Fang
    Acad Sinica, Taiwan.
    Phi Diep, Bui
    Uppsala Univ, Sweden.
    Holik, Lukas
    Brno Univ Technol, Czech Republic.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska fakulteten.
    Rummer, Philipp
    Uppsala Univ, Sweden.
    TRAU : SMT solver for string constraints2018Ingår i: PROCEEDINGS OF THE 2018 18TH CONFERENCE ON FORMAL METHODS IN COMPUTER AIDED DESIGN (FMCAD), IEEE , 2018, s. 165-169Konferensbidrag (Refereegranskat)
    Abstract [en]

    We introduce TRAU, an SMT solver for an expressive constraint language, including word equations, length constraints, context-free membership queries, and transducer constraints. The satisfiability problem for such a class of constraints is in general undecidable. The key idea behind TRAU is a technique called flattening, which searches for satisfying assignments that follow simple patterns. TRAU implements a Counter-Example Guided Abstraction Refinement (CEGAR) framework which contains both an under- and an over-approximation module. The approximations are refined in an automatic manner by information flow between the two modules. The technique implemented by TRAU can handle a rich class of string constraints and has better performance than state-of-the-art string solvers.

  • 217.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University.
    Atig, Mohammed Faouzi
    Uppsala University.
    Ganjei, Zeinab
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska fakulteten.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    Zhu, Yunyun
    Uppsala University.
    Verification of Cache Coherence Protocols wrt. Trace Filters2015Konferensbidrag (Refereegranskat)
    Abstract [en]

    We address the problem of parameterized verification of cache coherence protocols for hardware accelerated transactional memories. In this setting, transactional memories leverage on the versioning capabilities of the underlying cache coherence protocol. The length of the transactions, their number, and the number of manipulated variables (i.e., cache lines) are parameters of the verification problem. Caches in such systems are finite-state automata communicating via broadcasts and shared variables. We augment our system with filters that restrict the set of possible executable traces according to existing conflict resolution policies. We show that the verification of coherence for parameterized cache protocols with filters can be reduced to systems with only a finite number of cache lines. For verification, we show how to account for the effect of the adopted filters in a symbolic backward reachability algorithm based on the framework of constrained monotonic abstraction. We have implemented our method and used it to verify transactional memory coherence protocols with respect to different conflict resolution policies.

  • 218.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Dwarkadas, Sandhya
    University of Rochester, U.S.A..
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    Shriraman, Arrvindh
    Simon Fraser University, Canada.
    Zhu, Yunyun
    Uppsala University, Sweden.
    Verifying Safety and Liveness for the FlexTM Hybrid Transactional Memory2013Ingår i: Design, Automation & Test in Europe (DATE 2013), Grenoble, France, March 18-22, 2013., IEEE , 2013, s. 785-790Konferensbidrag (Refereegranskat)
    Abstract [en]

    We consider the verification of safety (strict se- rializability and abort consistency) and liveness (obstruction and livelock freedom) for the hybrid transactional memory framework FLEXTM. This framework allows for flexible imple- mentations of transactional memories based on an adaptation of the MESI coherence protocol. FLEXTM allows for both eager and lazy conflict resolution strategies. Like in the case of Software Transactional Memories, the verification problem is not trivial as the number of concurrent transactions, their size, and the number of accessed shared variables cannot be a priori bounded. This complexity is exacerbated by aspects that are specific to hardware and hybrid transactional memories. Our work takes into account intricate behaviours such as cache line based conflict detection, false sharing, invisible reads or non-transactional instructions. We carry out the first automatic verification of a hybrid transactional memory and establish, by adopting a small model approach, challenging properties such as strict serializability, abort consistency, and obstruction freedom for both an eager and a lazy conflict resolution strategies. We also detect an example that refutes livelock freedom. To achieve this, our prototype tool makes use the latest antichain based techniques to handle systems with tens of thousands of states.

  • 219.
    Abdulla, Parosh Aziz
    et al.
    Uppsala Univ, Sweden.
    Haziza, Frederic
    Uppsala Univ, Sweden.
    Holik, Lukas
    Uppsala Univ, Sweden; Brno Univ Technol, Czech Republic.
    Jonsson, Bengt
    Uppsala Univ, Sweden.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska fakulteten.
    Correction: An integrated specification and verification technique for highly concurrent data structures (vol 19, pg 549, 2017)2021Ingår i: International Journal on Software Tools for Technology Transfer, ISSN 1433-2779, E-ISSN 1433-2787, Vol. 23, artikel-id 825Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    n/a

  • 220.
    Abdulla, Parosh Aziz
    et al.
    Uppsala University, Sweden.
    Haziza, Frédéric
    Uppsala University, Sweden.
    Holik, Lukas
    Brno University of Technology, Czech Republic.
    Jonsson, Bengt
    Uppsala University, Sweden.
    Rezine, Ahmed
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    An Integrated Specification and Verification Technique for Highly Concurrent Data Structures2013Ingår i: The 19th International Conference on Tools and Algorithms for the Construction and Analysis of Systems (TACAS 2013), Rome, Italy, March 16-24, 2013. / [ed] Piterman, Nir, Smolka, Scott, 2013Konferensbidrag (Refereegranskat)
    Abstract [en]

    We present a technique for automatically verifying safety properties of concurrent programs, in particular programs which rely on subtle dependencies of local states of different threads, such as lock-free implementations of stacks and queues in an environment without garbage collection. Our technique addresses the joint challenges of infinite-state specifications, an unbounded number of threads, and an unbounded heap managed by explicit memory allocation. Our technique builds on the automata-theoretic approach to model checking, in which a specification is given by an automaton that observes the execution of a program and accepts executions that violate the intended specification.We extend this approach by allowing specifications to be given by a class of infinite-state automata. We show how such automata can be used to specify queues, stacks, and other data structures, by extending a data-independence argument. For verification, we develop a shape analysis, which tracks correlations between pairs of threads, and a novel abstraction to make the analysis practical. We have implemented our method and used it to verify programs, some of which have not been verified by any other automatic method before.

  • 221.
    Abdullaeva, Oliya
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Sahalianov, Ihor
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Silverå Ejneby, Malin
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Jakesova, Marie
    Brno Univ Technol, Czech Republic.
    Zozoulenko, Igor
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten.
    Liin, Sara
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för neurobiologi. Linköpings universitet, Medicinska fakulteten.
    Glowacki, Eric
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Laboratoriet för organisk elektronik. Linköpings universitet, Tekniska fakulteten. Brno Univ Technol, Czech Republic.
    Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M-Type Voltage-Gated Potassium Channels2022Ingår i: Advanced Science, E-ISSN 2198-3844, Vol. 9, nr 3, artikel-id 2103132Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    H2O2 plays a significant role in a range of physiological processes where it performs vital tasks in redox signaling. The sensitivity of many biological pathways to H2O2 opens up a unique direction in the development of bioelectronics devices to control levels of reactive-oxygen species (ROS). Here a microfabricated ROS modulation device that relies on controlled faradaic reactions is presented. A concentric pixel arrangement of a peroxide-evolving cathode surrounded by an anode ring which decomposes the peroxide, resulting in localized peroxide delivery is reported. The conducting polymer (poly(3,4-ethylenedioxythiophene) (PEDOT), is exploited as the cathode. PEDOT selectively catalyzes the oxygen reduction reaction resulting in the production of hydrogen peroxide (H2O2). Using electrochemical and optical assays, combined with modeling, the performance of the devices is benchmarked. The concentric pixels generate tunable gradients of peroxide and oxygen concentrations. The faradaic devices are prototyped by modulating human H2O2-sensitive Kv7.2/7.3 (M-type) channels expressed in a single-cell model (Xenopus laevis oocytes). The Kv7 ion channel family is responsible for regulating neuronal excitability in the heart, brain, and smooth muscles, making it an ideal platform for faradaic ROS stimulation. The results demonstrate the potential of PEDOT to act as an H2O2 delivery system, paving the way to ROS-based organic bioelectronics.

    Ladda ner fulltext (pdf)
    fulltext
  • 222.
    Abdullah Jan, Mirza
    et al.
    Linköpings universitet, Institutionen för systemteknik.
    Ahsan, Mahmododfateh
    Linköpings universitet, Institutionen för systemteknik.
    Multi-View Video Transmission over the Internet2010Självständigt arbete på avancerad nivå (masterexamen), 30 poäng / 45 hpStudentuppsats (Examensarbete)
    Abstract [en]

    3D television using multiple views rendering is receiving increasing interest. In this technology a number of video sequences are transmitted simultaneously and provides a larger view of the scene or stereoscopic viewing experience. With two views stereoscopic rendition is possible. Nowadays 3D displays are available that are capable of displaying several views simultaneously and the user is able to see different views by moving his head.

    The thesis work aims at implementing a demonstration system with a number of simultaneous views. The system will include two cameras, computers at both the transmitting and receiving end and a multi-view display. Besides setting up the hardware, the main task is to implement software so that the transmission can be done over an IP-network.

    This thesis report includes an overview and experiences of similar published systems, the implementation of real time video, its compression, encoding, and transmission over the internet with the help of socket programming and finally the multi-view display in 3D format.  This report also describes the design considerations more precisely regarding the video coding and network protocols.

    Ladda ner fulltext (pdf)
    FULLTEXT02
  • 223.
    Abdullah, M Ailieen
    et al.
    Royal Institute of Technology.
    Öhrwall Rönnbäck, Anna
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Industriell marknadsföring och industriell ekonomi. Linköpings universitet, Tekniska högskolan.
    Ölundh Sandström, Gunilla
    Royal Institute of Technology.
    Building Networks for Delivering Integrated Product-Service Offerings (IPSOs)2010Ingår i: Proceedings of 2nd CIRP IPS2 Conference 2010 - Industrial product-service systems -IPS², CIRP , 2010Konferensbidrag (Refereegranskat)
    Abstract [en]

    The paper describes the effect of forming business networks and collaborations for the purpose of developing an Integrated Product-Service Offering (IPSO) using the Product/Service Systems (PSS). The research method is an in-depth case study of a joint venture formed by four companies developing a new technology for chemical extraction from water sludge waste within the pulp and paper industry.

    Combining literature from PSS, network theories and collaborative product development, this paper puts forward the benefits for SMEs to collaborate in business networks and produce IPSOs when introducing a new technology in an emerging market. The case study shows that working towards the new market would not have been possible if each party acted individually or maintained their traditional buyer-supplieroperator roles, and that IPSOs can reduce the business risk.

    Ladda ner fulltext (pdf)
    fulltext
  • 224.
    Abdullahi, Khadra
    et al.
    Linköpings universitet, Institutionen för kultur och samhälle, Avdelningen för socialt arbete.
    Berg, Elvira
    Linköpings universitet, Institutionen för kultur och samhälle, Avdelningen för socialt arbete.
    Projekt Svensk: En kvalitativ studie om migranters identiteter och identitetsprocesser2023Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Syftet med vår studie är att fördjupa kunskapen om hur migranter som kommer till Sverige från länder utanför EU upplever och beskriver sina identitetsprocesser. Vi har använt tre självbiografiska berättelser skrivna av personer med utländsk bakgrund: Sverigevänner (2019), Den udda fågeln (2022) och Min väg från flykting till hela Sveriges polis (2022). Vi har använt en hermenutisk utgångspunkt, en narrativ analysmetod, Jenkins sociala identitetsteori, Goffmans stigmateori, Baumans teori om "Vi" och "De andra", samt Hammarén och Johanssons hybrida identitetsbegrepp.

    Vi kom fram till att identitet ändras i individens interaktion med omgivningen. Studien visar också att faktorer, som kan tolkas ha betydele i identitetsprocesser, är individens sociala positioner, respekt och erkännande, språksvårigheter, relationen med arbetsmarknaden och behärskande av sociala koder, individens annanhet och upplevelsen av grupptillhörighet. Utifrån detta har vi observerat att migranter strävar efter att bli en del av majoritetssamhället, men även upplever att de skulle vilja kunna behålla sin integritet. 

    Studien fokuserar på migranters upplevelser av sina identitetsprocesser. Vi har observerat att för att bli en del av det svenska samhället, krävs det mycket arbete och ansträngning från migrantens sida att utveckla en identitet som passar in i det nya samhället. Vi har likställt detta arbete med ett projekt. Med inspiration från boken Sverigevänner (2019) skriven av Arash Sanari, har vi valt att benämna denna studie till Projekt Svensk.

    Ladda ner fulltext (pdf)
    fulltext
  • 225.
    Abdullahi, Zahra
    et al.
    Linköpings universitet, Institutionen för kultur och samhälle.
    Danielsson Benachir, Chahrazad
    Linköpings universitet, Institutionen för kultur och samhälle.
    Porträtteringar av den missbrukande föräldern: En kvalitativ analys av fyra nordiska filmer2022Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Syftet med denna kvalitativa studie är att undersöka vilka egenskaper och beskrivningar som ingår i konstruktionen av en missbrukande förälder i fyra nordiska filmer. De studerade filmerna är Trädgårdsgatan (2017), Mig äger ingen (2013), Submarino (2010) och Svinalängorna (2010). Syftet med studien är även att undersöka hur framställningen av familjemedlemmars reaktioner på missbruket i filmerna bidrar till konstruktionen av den missbrukande föräldern. Studien utgår ifrån ett socialkonstruktionistiskt perspektiv och använder narrativ metod. Två centrala teoretiska begrepp som används är normalitet och avvikelse för att analysera hur förälderns föräldraskap konstrueras som antingen normalt eller avvikande. Eftersom narrativ metod används analyseras filmerna som berättelser, mer specifikt berättelser om familjer. I studien har vi funnit att den missbrukande föräldern konstrueras genom önskvärda respektive avvikande egenskaper.

    I analysen har vi utifrån nyckelscener och nyckelcitat synliggjort de fem mest utmärkande egenskaperna som föräldern tillskrivits genom filmernas berättelser. Dessa är att vara socialt utsatt, ansvarslös, kontrollös, medveten (kring det som avviker) och känslomässigt nära till sitt barn. Egenskaperna har sorterats efter fem teman och under dessa har vi analyserat varje tillskriven egenskap och hur de bidrar till konstruktionen av den missbrukande föräldern i de studerade filmerna. Sammantaget visar vår studie att det är en viss stereotypisk bild av en förälder som förmedlas, men även en komplex sådan. Vår förhoppning med studien är att skapa medvetenhet kring hur film kan framställa, producera och reproducera vissa stereotypa bilder eller föreställningar för ett fenomen, som i detta fall är ett föräldraskap i missbruk.

    Ladda ner fulltext (pdf)
    Examensarbete
  • 226.
    Abdul-Mumuni, Abdallah
    Linköpings universitet, Ekonomiska institutionen.
    Conflict Resolution in West Africa: A Comparative Analysis of Sierra Leone and Liberia2005Självständigt arbete på avancerad nivå (magisterexamen)Studentuppsats
    Abstract [en]

    This paper is a Master thesis for the Master’s program in International and European Relations in the Department of Management and Economics at Linköping University. As the title indicates, the aim of this thesis is to make a comparative analysis of the conflict resolution initiatives that were employed in the Sierra Leonean and Liberian conflicts. The research questions are:

    • What were the root causes and trajectories of the Sierra Leonean and Liberian conflicts?

    • What were the conflict resolution initiatives employed in resolving both conflicts?

    • Why did the Lome Peace Accord succeed in the case of Sierra Leone whilst the Abuja Peace Accord failed in bringing peace to Liberia?

    In order to answer the afore-mentioned questions and fulfil the aim of this paper, a qualitative research method has been chosen. The study is mainly based on secondary sources such as textbooks, official documents from ECOWAS and the UN, articles, magazines and newspapers as well as internet resources. In making the comparative analysis the Conflict Transformation Model as espoused by Kumar Rupesinghe has been utilized. This model has specifically helped in explaining the reasons why peace returned to Sierra Leone but eluded the people of Liberia for a long time. The conclusion drawn from the study is that a multi-track approach is required in dealing with conflicts in West Africa so that it would touch on the context of the conflict, the conflict structure, the intra-party as well as the inter- party divisions and the broader system of society and governance within the conflict area.

    Ladda ner fulltext (pdf)
    FULLTEXT01
  • 227.
    Abdul-Sattar Aljabery, Firas
    et al.
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för kirurgi, ortopedi och onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Urologiska kliniken i Östergötland.
    Jancke, Georg
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för kirurgi, ortopedi och onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Urologiska kliniken i Östergötland.
    Skoglund, Per
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för kirurgi, ortopedi och onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Urologiska kliniken i Östergötland.
    Hallböök, Olof
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för kirurgi, ortopedi och onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Kirurgiska kliniken US.
    Stapled versus robot-sewn ileo-ileal anastomosis during robot-assisted radical cystectomy: a review of outcomes in urinary bladder cancer patients2021Ingår i: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813, Vol. 55, nr 1, s. 41-45Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    BackgroundWhereas the literature has demonstrated an acceptable safety profile of stapled anastomoses when compared to the hand-sewn alternative in open surgery, the choice of intestinal anastomosis using sutures or staples remains inadequately investigated in robotic surgery. The purpose of this study was to compare the surgical outcomes of both anastomotic techniques in robotic-assisted radical cystectomy.MethodsA retrospective analysis of patients with urinary bladder cancer undergoing cystectomy with urinary diversion and with ileo-ileal intestinal anastomosis at a single tertiary centre (2012–2018) was undertaken. The robotic operating time, hospital stay and GI complications were compared between the robotic-sewn (RS) and stapled anastomosis (SA) groups. The only difference between the groups was the anastomosis technique; the other technical steps during the operation were the same. Primary outcomes were GI complications; the secondary outcome was robotic operation time.ResultsThere were 155 patients, of which 112 (73%) were male. The median age was 71 years old. A surgical stapling device was used to create 66 (43%) separate anastomoses, while a robot-sewn method was employed in 89 (57%) anastomoses. There were no statistically significant differences in primary and secondary outcomes between RS and SA.ConclusionsCompared to stapled anastomosis, a robot-sewn ileo-ileal anastomosis may serve as an alternative and cost-saving approach. 

  • 228.
    Abdul-Sattar Aljabery, Firas
    et al.
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för kirurgi, ortopedi och onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Urologiska kliniken i Östergötland.
    Liedberg, Fredrik
    Skane Univ Hosp, Sweden; Lund Univ, Sweden.
    Haggstrom, Christel
    Uppsala Univ, Sweden; Umea Univ, Sweden.
    Strock, Viveka
    Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden.
    Hosseini, Abolfazl
    Karolinska Univ Hosp, Sweden.
    Gardmark, Truls
    Karolinska Inst, Sweden.
    Sherif, Amir
    Umea Univ, Sweden.
    Jerlstrom, Tomas
    Orebro Univ, Sweden.
    Malmstrom, Per-Uno
    Uppsala Univ, Sweden.
    Hagberg, Oskar
    Lund Univ, Sweden.
    Holmberg, Lars
    Uppsala Univ, Sweden; Kings Coll London, England.
    Treatment and prognosis of patients with urinary bladder cancer with other primary cancers: a nationwide population-based study in the Bladder Cancer Data Base Sweden (BladderBaSe)2020Ingår i: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, Vol. 126, nr 5, s. 625-632Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective To study how patients with urinary bladder cancer (UBC) with previous or concomitant other primary cancers (OPCs) were treated, and to investigate their prognosis. Patients And Methods Using nationwide population-based data in the Bladder Cancer Data Base Sweden (BladderBaSe), we analysed the probability of treatment with curative intent, and UBC-specific and overall survival (OS) in patients with UBC diagnosed in the period 1997-2014 with or without OPC. The analyses considered the patients characteristics, UBC tumour stage at diagnosis, and site of OPC. Results There were 38 689 patients, of which 9804 (25%) had OPCs. Those with synchronous OPCs more often had T2 and T3 tumours and clinically distant disease at diagnosis than those with UBC only. Patients with synchronous prostate cancer, female genital cancer and lower gastro-intestinal cancer were more often treated with curative intent than patients with UBC only. When models of survival were adjusted for age at diagnosis, marital status, education, year of diagnosis, Charlson Comorbidity Index and T-stage, UBC-specific survival was similar to patients with UBC only, but OS was lower for patients with synchronous OPC, explained mainly by deaths in OPC primaries with a bad prognosis. Conclusions OPC is common in patients with UBC. Treatment for UBC, after or in conjunction with an OPC, should not be neglected and carries just as high a probability of success as treatment in patients with UBC only. The needs of patients with UBC and OPC, and optimisation of their treatment considering their complicated disease trajectory are important areas of research.

    Ladda ner fulltext (pdf)
    fulltext
  • 229.
    Abdul-Sattar Aljabery, Firas
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Urologiska kliniken i Östergötland.
    Liedberg, Fredrik
    Skane Univ Hosp, Sweden; Lund Univ, Sweden.
    Haggstrom, Christel
    Uppsala Univ, Sweden; Umea Univ, Sweden.
    Strock, Viveka
    Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden.
    Hosseini, Abolfazl
    Karolinska Univ Hosp, Sweden.
    Gardmark, Truls
    Karolinska Inst, Sweden.
    Sherif, Amir
    Umea Univ, Sweden.
    Jerlstrom, Tomas
    Orebro Univ, Sweden.
    Malmstrom, Per-Uno
    Uppsala Univ, Sweden.
    Holmberg, Lars
    Uppsala Univ, Sweden; Kings Coll London, England.
    Hagberg, Oskar
    Lund Univ, Sweden.
    Jahnson, Staffan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Urologiska kliniken i Östergötland.
    Management and outcome of muscle-invasive bladder cancer with clinical lymph node metastases. A nationwide population-based study in the bladder cancer data base Sweden (BladderBaSe)2019Ingår i: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813, Vol. 53, nr 5, s. 332-338Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To investigate the clinical management and outcome of patients with muscle-invasive bladder cancer with clinical lymph node involvement, using longitudinal nationwide population-based data. Methods: In the Bladder Cancer Data Base Sweden (BladderBaSe), treatment and survival in patients with urinary bladder cancer clinical stage T2-T4 N + M0 diagnosed between 1997 and 2014 was investigated. Patients characteristics were studied in relation to TNM classification, curative or palliative treatment, cancer-specific (CSS) and overall survival (OS). Age at diagnosis was categorised as amp;lt;= 60, 61-70, 71-80 and amp;gt;80 years, and time periods were stratified as follows: 1997-2001, 2002-2005, 2006-2010 and 2011-2014. Results: There were 786 patients (72% males) with a median age of 71 years (interquartile range = 64-79 years). The proportion of patients with high comorbidity increased over time. Despite similar low comorbidity, curative treatment was given to 44% and to 70% of those in older (amp;gt;70 years) and younger age groups, respectively. Curative treatment decreased over time, but chemotherapy and cystectomy increased to 25% during the last time period. Patients with curative treatment had better survival compared to those with palliative treatment, both regarding CSS and OS in the whole cohort and in all age groups. Conclusions: The low proportion of older patients undergoing treatment with curative intent, despite no or limited comorbidity, indicates missed chances of treatment with curative intent. The reasons for an overall decrease in curative treatment over time need to be analysed and the challenge of coping with an increasing proportion of node-positive patients with clinically significant comorbidity needs to be met.

  • 230.
    Abebe, Meaza Eshetu
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Företagsekonomi.
    Kalinina, Ekaterina
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Företagsekonomi.
    Coordination of inter-organizational projects within creative industries: A contextual perspective2012Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Inter-organizational projects have become common forms of organizing in various industries such as construction, advertising, music, film making etc. The unique structural nature of Inter-organizational projects coupled with the fact that they carried out through the participation of multiple organizations, raises issues of coordination. Particularly when it comes to creative industries, coordination is challenged by demand and transactional uncertainties. In order to understand how inter-organizational projects achieve coordination in such situations, it is important to study their interior processes putting in consideration their environmental context. 

    The aim of this research is to study how network embeddedness enhances coordination in inter-organizational projects within creative industries.

    Inter-organizational projects: are projects that are carried out through the collaboration of multiple legally independent organizations

    Inter-organizational networks: refer to sets of long-term ties among independent organizations that are engaged in continuous exchange relations.

    Embeddedness: refers to the continuous interaction of individuals, organizations, projects etc. with their environmental context.

    Macrocultures: refer to the shared beliefs, norms values rules and practices with in inter- organizational networks that guide members on their actions.

    A qualitative approach using a multiple comparative case study was conducted. Accordingly four projects chosen from creative industries were studied using both primary and secondary data.

    Macrocultures that are embedded inter-organizational networks facilitate coordination within inter-organizational projects. Further projects that differ in their constituents task nature, time duration and team composition relied on different types of embeddedness for coordination.

    Ladda ner fulltext (pdf)
    ISRN LIU-IEI-FIL-A--1201237--SE
  • 231. Beställ onlineKöp publikationen >>
    Abedini, Fereshteh
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    2D and 3D Halftoning for Appearance Reproduction2023Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    The appearance of an object is determined by its chromatic and geometric qualities in its surrounding environment using four optical parameters: color, gloss, translucency, and surface texture. Reconstructing the appearance of objects is of great importance in many applications, including creative industries, packaging, fine-art reproduction, medical simulation, and prosthesis-making. Printers are reproduction devices capable of replicating objects’ appearance in 2D and 3D forms. With the introduction of new printing technologies, new inks and materials, and demands for innovative applications, creating accurate reproduction of the desired visual appearance has become challenging. Thus, the appearance reproduction workflow requires improvements and adaptations. 

    Accurate color reproduction is a critical quality measure in reproducing the desired appearance in any printing process. However, printers are devices with a limited number of inks that can either print a dot or leave it blank at a specific position on a substrate; hence, to reproduce different colors, optimal placement of the available inks is needed. Halftoning is a technique that deals with this challenge by generating a spatial distribution of the available inks that creates an illusion of the target color when viewed from a sufficiently large distance. Halftoning is a fundamental part of the color reproduction task in any full-color printing pipeline, and it is an effective technique to increase the potential of printing realistic and complex appearances. Although halftoning has been used in 2D printing for many decades, it still requires improvements in reproducing fine details and structures of images. Moreover, the emergence of new technologies in 3D printing introduces a higher degree of freedom and more parameters to the field of appearance reproduction. Therefore, there is a critical need for extensive studies to revisit existing halftoning algorithms and develop novel approaches to produce high quality prints that match the target appearance faithfully. This thesis aims at developing halftoning algorithms to improve appearance reproduction in 2D and 3D printing. 

    Contributions of this thesis in the 2D domain is a dynamic sharpness-enhancing halftoning approach, which adaptively varies the local sharpness of the halftone image based on different textures in the original image for realistic appearance printing. The results show improvements in halftone quality in terms of sharpness, preserving structural similarity, and decreasing color reproduction error. The main contribution of this thesis in 3D printing is extending a high quality 2D halftoning algorithm to the 3D domain. The proposed method is then integrated with a multi-layer printing approach, where ink is deposited at variable depths to improve the reproduction of tones and fine details. Results demonstrate that the proposed method accurately reproduces tones and details of the target appearance. Another contribution of this thesis is studying the effect of halftoning on the perceived appearance of 3D printed surfaces. According to the results, changing the dot placement based on the elevation variation of the underlying geometry can potentially control the perception of the 3D printed appearance. It implies that the choice of halftone may prove helpful in eliminating unwanted artifacts, enhancing the object’s geometric features, and producing a more accurate 3D appearance. The proposed methods in this thesis have been evaluated using different printing techniques.    

    Delarbeten
    1. 3D Halftoning based on Iterative Method Controlling Dot Placement
    Öppna denna publikation i ny flik eller fönster >>3D Halftoning based on Iterative Method Controlling Dot Placement
    2020 (Engelska)Konferensbidrag, Muntlig presentation med publicerat abstract (Refereegranskat)
    Abstract [en]

    Realistic appearance reproduction is of great importance in 3D printing’s applications. Halftoning as a necessary process in printing has a great impact on creating visually pleasant appearance. In this article, we study the aspects of adapting and applying Iterative Method Controlling Dot Placement (IMCDP) to halftone three-dimensional surfaces. Our main goal is to extend the 2D algorithm to a 3D halftoning approach with minor modifications. The results show high-quality reproduction for all gray tones. The 3D halftoning algorithm is not only free of undesirable artifacts, it also produces fully symmetric and wellformed halftone structures even in highlight and shadow regions.

    Nyckelord
    3D printing, 3D halftoning, Surface reproduction
    Nationell ämneskategori
    Mediateknik
    Identifikatorer
    urn:nbn:se:liu:diva-171744 (URN)10.2352/ISSN.2169-4451.2020.36.69 (DOI)
    Konferens
    Printing for Fabrication, Online 2020, October 19-21
    Tillgänglig från: 2020-12-01 Skapad: 2020-12-01 Senast uppdaterad: 2023-09-26Bibliografiskt granskad
    2. 3D Surface Structures and 3D Halftoning
    Öppna denna publikation i ny flik eller fönster >>3D Surface Structures and 3D Halftoning
    2020 (Engelska)Konferensbidrag, Publicerat paper (Refereegranskat)
    Abstract [en]

    As 3D printing is becoming increasingly popular, the demand for high quality surface reproduction is also increasing. Like in 2D printing, halftoning plays an important role in the quality of the surface reproduction. Developing advanced 3D halftoning methods for 3D printing and adapting them to the structure of the surface is therefore essential for improving surface reproduction quality. In this paper, an extension of an iterative 2D halftoning method to 3D is used to apply different halftone structures on 3D surfaces. The results show that using different halftones based on the 3D geometrical structure of the surface and/or the viewing angle in combination with the structure of the texture being mapped on the surface can potentially improve the quality of the appearance of 3D surfaces.

    Ort, förlag, år, upplaga, sidor
    The Society for Imaging Science and Technology, 2020
    Nyckelord
    3D halftoning, Hybrid halftoning, 3D surface structures
    Nationell ämneskategori
    Mediateknik
    Identifikatorer
    urn:nbn:se:liu:diva-170797 (URN)10.2352/ISSN.2169-4451.2020.36.75 (DOI)
    Konferens
    Printing for Fabrication 2020
    Tillgänglig från: 2020-10-22 Skapad: 2020-10-22 Senast uppdaterad: 2024-01-02Bibliografiskt granskad
    3. The Effect of Halftoning on the Appearance of 3D Printed Surfaces
    Öppna denna publikation i ny flik eller fönster >>The Effect of Halftoning on the Appearance of 3D Printed Surfaces
    2021 (Engelska)Konferensbidrag, Publicerat paper (Refereegranskat)
    Abstract [en]

    Managing the final appearance of 3D surfaces is an interesting and essential topic in 3D printing applications. Knowledge about the parameters which influence the 3D surface reproduction quality enables engineers to achieve the final appearance as accurately as designed. Many studies have been conducted to explore numerous parameters that affect the quality of 3D surface reproduction. This work contributes to verifying the role of halftoning in increasing the 3D surface visual quality and the control over the surface appearance of a 3D printed object. The results show that applying different halftones according to the geometrical characteristics of the 3D surface could emphasize or diminish the perceived 3D geometrical structures of a shape. The experimental results are in line with the simulated outputs reported in previous work. Our findings might introduce a new approach towards having more control over 3D appearance reproduction without changing the material or printer settings.

    Nyckelord
    3D printing, Halftoning, Surface appearance
    Nationell ämneskategori
    Mediateknik
    Identifikatorer
    urn:nbn:se:liu:diva-180696 (URN)
    Konferens
    47th Annual Conference of Iarigai
    Tillgänglig från: 2021-10-29 Skapad: 2021-10-29 Senast uppdaterad: 2023-09-26Bibliografiskt granskad
    4. Structure-Aware Halftoning Using the Iterative Method Controlling the Dot Placement
    Öppna denna publikation i ny flik eller fönster >>Structure-Aware Halftoning Using the Iterative Method Controlling the Dot Placement
    2021 (Engelska)Ingår i: Journal of Imaging Science and Technology, ISSN 1062-3701, E-ISSN 1943-3522, Vol. 65, nr 6Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Many image reproduction devices, such as printers, are limited to only a few numbers of printing inks. Halftoning, which is the process to convert a continuous-tone image into a binary one, is, therefore, an essential part of printing. An iterative halftoning method, called Iterative Halftoning Method Controlling the Dot Placement (IMCDP), which has already been studied by research scholars, generally results in halftones of good quality. In this paper, we propose a structure-based alternative to this algorithm that improves the halftone image quality in terms of sharpness, structural similarity, and tone preservation. By employing appropriate symmetrical and non-symmetrical Gaussian filters inside the proposed halftoning method, it is possible to adaptively change the degree of sharpening in different parts of the continuous-tone image. This is done by identifying a dominant line in the neighborhood of each pixel in the original image, utilizing the Hough Transform, and aligning the dots along the dominant line. The objective and subjective quality assessments verify that the proposed structure-based method not only results in sharper halftones, giving more three-dimensional impression, but also improves the structural similarity and tone preservation. The adaptive nature of the proposed halftoning method makes it an appropriate algorithm to be further developed to a 3D halftoning method, which could be adapted to different parts of a 3D object by exploiting both the structure of the images being mapped and the 3D geometrical structure of the underlying printed surface.

    Ort, förlag, år, upplaga, sidor
    I S & T-SOC IMAGING SCIENCE TECHNOLOGY, 2021
    Nyckelord
    Halftoning, Structure-Aware Halftoning, Hough Transform, Image Quality Evaluation
    Nationell ämneskategori
    Mediateknik
    Identifikatorer
    urn:nbn:se:liu:diva-181613 (URN)10.2352/j.imagingsci.technol.2021.65.6.060404 (DOI)000734009600011 ()
    Anmärkning

    Funding: ApPEARS (Appearance Printing European Advanced Research School); European Unions Horizon 2020 programme under the Marie Skodowska-Curie [814158]

    Tillgänglig från: 2021-12-04 Skapad: 2021-12-04 Senast uppdaterad: 2023-09-26Bibliografiskt granskad
    5. Structure-Aware Color Halftoning with Adaptive Sharpness Control
    Öppna denna publikation i ny flik eller fönster >>Structure-Aware Color Halftoning with Adaptive Sharpness Control
    2022 (Engelska)Ingår i: Journal of Imaging Science and Technology, ISSN 1062-3701, E-ISSN 1943-3522, Vol. 66, nr 6, artikel-id 060404Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Structure-aware halftoning algorithms aim at improving their non-structure-aware version by preserving high-frequency details, structures, and tones and by employing additional information from the input image content. The recently proposed achromatic structure-aware Iterative Method Controlling the Dot Placement (IMCDP) halftoning algorithm uses the angle of the dominant line in each pixels neighborhood as supplementary information to align halftone structures with the dominant orientation in each region and results in sharper halftones, gives a more three-dimensional impression, and improves the structural similarity and tone preservation. However, this method is developed only for monochrome halftoning, the degree of sharpness enhancement is constant for the entire image, and the algorithm is prohibitively expensive for large images. In this paper, we present a faster and more flexible approach for representing the image structure using a Gabor-based orientation extraction technique which improves the computational performance of the structure-aware IMCDP by an order of magnitude while improving the visual qualities. In addition, we extended the method to color halftoning and studied the impact of orientation information in different color channels on improving sharpness enhancement, preserving structural similarity, and decreasing color reproduction error. Furthermore, we propose a dynamic sharpness enhancement approach, which adaptively varies the local sharpness of the halftone image based on different textures across the image. Our contributions in the present work enable the algorithm to adaptively work on large images with multiple regions and different textures. (C) 2022 Society for Imaging Science and Technology.

    Ort, förlag, år, upplaga, sidor
    I S & T-SOC IMAGING SCIENCE TECHNOLOGY, 2022
    Nationell ämneskategori
    Mediateknik
    Identifikatorer
    urn:nbn:se:liu:diva-192705 (URN)10.2352/J.ImagingSci.Technol.2022.66.6.060404 (DOI)000939908300011 ()
    Anmärkning

    Funding Agencies|ApPEARS (Appearance Printing European Advanced Research School); European Unions Horizon 2020 programme under the Marie Sklodowska-Curie grant [814158]

    Tillgänglig från: 2023-03-31 Skapad: 2023-03-31 Senast uppdaterad: 2023-09-26
    6. Effect of halftones on printing iridescent colors
    Öppna denna publikation i ny flik eller fönster >>Effect of halftones on printing iridescent colors
    2023 (Engelska)Ingår i: IS&T Electronic Imaging: Color Imaging XXVIII: Displaying, Processng, Hardcopy, and Applications, The Society for Imaging Science and Technology, 2023, Vol. 35, s. 1-6Konferensbidrag, Publicerat paper (Refereegranskat)
    Abstract [en]

    The iridescent effect produced by structural color is difficult (if not impossible) to capture and print using traditional CMYK pigments. The so called RGB reflective pigments, nonetheless, generate angle-dependent colors by light interference. A layered surface structure generated by the pigments’ particles on a substrate reflects light waves of different wavelengths at different viewing angles according to the optical principle known as the Bragg Law. In this work, we have studied the influence of different halftone structures on printed images, produced with RGB reflective inks via screen printing. The main goal was to enhance the iridescence of a printed reproduction by studying the performance of different halftone algorithms on a screen printing process. We investigated the influence of different halftone structures in creating different spatial combinations of inks on a print to reproduce the image of an iridescent feathered headdress. We applied first-order, second-order, and structure-aware FM halftones to compare how they influence the reproduction of the material appearance of the object represented in the original image. The results show that the structure-ware halftones improve the representation of the image structures and details. Therefore, it could better convey the 3D surface features that produce iridescence in real feathers.

    Ort, förlag, år, upplaga, sidor
    The Society for Imaging Science and Technology, 2023
    Nationell ämneskategori
    Mediateknik
    Identifikatorer
    urn:nbn:se:liu:diva-197992 (URN)
    Konferens
    IS&T Electronic Imaging
    Tillgänglig från: 2023-09-20 Skapad: 2023-09-20 Senast uppdaterad: 2023-09-26
    Ladda ner fulltext (pdf)
    fulltext
    Ladda ner (png)
    presentationsbild
  • 232.
    Abedini, Fereshteh
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Effect of halftones on printing iridescent colors2023Ingår i: IS&T Electronic Imaging: Color Imaging XXVIII: Displaying, Processng, Hardcopy, and Applications, The Society for Imaging Science and Technology, 2023, Vol. 35, s. 1-6Konferensbidrag (Refereegranskat)
    Abstract [en]

    The iridescent effect produced by structural color is difficult (if not impossible) to capture and print using traditional CMYK pigments. The so called RGB reflective pigments, nonetheless, generate angle-dependent colors by light interference. A layered surface structure generated by the pigments’ particles on a substrate reflects light waves of different wavelengths at different viewing angles according to the optical principle known as the Bragg Law. In this work, we have studied the influence of different halftone structures on printed images, produced with RGB reflective inks via screen printing. The main goal was to enhance the iridescence of a printed reproduction by studying the performance of different halftone algorithms on a screen printing process. We investigated the influence of different halftone structures in creating different spatial combinations of inks on a print to reproduce the image of an iridescent feathered headdress. We applied first-order, second-order, and structure-aware FM halftones to compare how they influence the reproduction of the material appearance of the object represented in the original image. The results show that the structure-ware halftones improve the representation of the image structures and details. Therefore, it could better convey the 3D surface features that produce iridescence in real feathers.

  • 233.
    Abedini, Fereshteh
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Gooran, Sasan
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Structure-Aware Color Halftoning with Adaptive Sharpness Control2022Ingår i: Journal of Imaging Science and Technology, ISSN 1062-3701, E-ISSN 1943-3522, Vol. 66, nr 6, artikel-id 060404Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Structure-aware halftoning algorithms aim at improving their non-structure-aware version by preserving high-frequency details, structures, and tones and by employing additional information from the input image content. The recently proposed achromatic structure-aware Iterative Method Controlling the Dot Placement (IMCDP) halftoning algorithm uses the angle of the dominant line in each pixels neighborhood as supplementary information to align halftone structures with the dominant orientation in each region and results in sharper halftones, gives a more three-dimensional impression, and improves the structural similarity and tone preservation. However, this method is developed only for monochrome halftoning, the degree of sharpness enhancement is constant for the entire image, and the algorithm is prohibitively expensive for large images. In this paper, we present a faster and more flexible approach for representing the image structure using a Gabor-based orientation extraction technique which improves the computational performance of the structure-aware IMCDP by an order of magnitude while improving the visual qualities. In addition, we extended the method to color halftoning and studied the impact of orientation information in different color channels on improving sharpness enhancement, preserving structural similarity, and decreasing color reproduction error. Furthermore, we propose a dynamic sharpness enhancement approach, which adaptively varies the local sharpness of the halftone image based on different textures across the image. Our contributions in the present work enable the algorithm to adaptively work on large images with multiple regions and different textures. (C) 2022 Society for Imaging Science and Technology.

  • 234.
    Abedini, Fereshteh
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Gooran, Sasan
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Kitanovski, Vlado
    Norwegian University of Science and Technology, Faculty of Information Technology and Electrical Engineering, Department of Computer Science, Gjøvik, Norway.
    Nyström, Daniel
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Structure-Aware Halftoning Using the Iterative Method Controlling the Dot Placement2021Ingår i: Journal of Imaging Science and Technology, ISSN 1062-3701, E-ISSN 1943-3522, Vol. 65, nr 6Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Many image reproduction devices, such as printers, are limited to only a few numbers of printing inks. Halftoning, which is the process to convert a continuous-tone image into a binary one, is, therefore, an essential part of printing. An iterative halftoning method, called Iterative Halftoning Method Controlling the Dot Placement (IMCDP), which has already been studied by research scholars, generally results in halftones of good quality. In this paper, we propose a structure-based alternative to this algorithm that improves the halftone image quality in terms of sharpness, structural similarity, and tone preservation. By employing appropriate symmetrical and non-symmetrical Gaussian filters inside the proposed halftoning method, it is possible to adaptively change the degree of sharpening in different parts of the continuous-tone image. This is done by identifying a dominant line in the neighborhood of each pixel in the original image, utilizing the Hough Transform, and aligning the dots along the dominant line. The objective and subjective quality assessments verify that the proposed structure-based method not only results in sharper halftones, giving more three-dimensional impression, but also improves the structural similarity and tone preservation. The adaptive nature of the proposed halftoning method makes it an appropriate algorithm to be further developed to a 3D halftoning method, which could be adapted to different parts of a 3D object by exploiting both the structure of the images being mapped and the 3D geometrical structure of the underlying printed surface.

    Ladda ner (png)
    preview image
  • 235.
    Abedini, Fereshteh
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Gooran, Sasan
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Nyström, Daniel
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    3D Halftoning based on Iterative Method Controlling Dot Placement2020Konferensbidrag (Refereegranskat)
    Abstract [en]

    Realistic appearance reproduction is of great importance in 3D printing’s applications. Halftoning as a necessary process in printing has a great impact on creating visually pleasant appearance. In this article, we study the aspects of adapting and applying Iterative Method Controlling Dot Placement (IMCDP) to halftone three-dimensional surfaces. Our main goal is to extend the 2D algorithm to a 3D halftoning approach with minor modifications. The results show high-quality reproduction for all gray tones. The 3D halftoning algorithm is not only free of undesirable artifacts, it also produces fully symmetric and wellformed halftone structures even in highlight and shadow regions.

    Ladda ner (png)
    preview image
  • 236.
    Abedini, Fereshteh
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Gooran, Sasan
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Nyström, Daniel
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Medie- och Informationsteknik. Linköpings universitet, Tekniska fakulteten.
    The Effect of Halftoning on the Appearance of 3D Printed Surfaces2021Konferensbidrag (Refereegranskat)
    Abstract [en]

    Managing the final appearance of 3D surfaces is an interesting and essential topic in 3D printing applications. Knowledge about the parameters which influence the 3D surface reproduction quality enables engineers to achieve the final appearance as accurately as designed. Many studies have been conducted to explore numerous parameters that affect the quality of 3D surface reproduction. This work contributes to verifying the role of halftoning in increasing the 3D surface visual quality and the control over the surface appearance of a 3D printed object. The results show that applying different halftones according to the geometrical characteristics of the 3D surface could emphasize or diminish the perceived 3D geometrical structures of a shape. The experimental results are in line with the simulated outputs reported in previous work. Our findings might introduce a new approach towards having more control over 3D appearance reproduction without changing the material or printer settings.

    Ladda ner (png)
    preview image
  • 237.
    Abednazari, Hossein
    et al.
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Infektionsmedicin. Linköpings universitet, Hälsouniversitetet.
    Xu, Junyang
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Infektionsmedicin. Linköpings universitet, Hälsouniversitetet.
    Millinger, Eva
    Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Lungmedicinska kliniken. Linköpings universitet, Hälsouniversitetet.
    Brudin, Lars
    Department of Clinical Physiology, County Hospital, Kalmar, Sweden.
    Forsberg, Pia
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Infektionsmedicin. Linköpings universitet, Hälsouniversitetet.
    Nayeri, Fariba
    Linköpings universitet, Institutionen för molekylär och klinisk medicin, Infektionsmedicin. Linköpings universitet, Hälsouniversitetet.
    Hepatocyte growth factor is a better indicator of therapeutic response than C-reactive protein within the first day of treatment in pneumonia2006Ingår i: Chemotherapy, ISSN 0009-3157, E-ISSN 1421-9794, Vol. 52, nr 5, s. 260-263Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Acute bacterial infectious diseases are mostly treated empirically at admission before the culture results are available. According to the risk for serious complications in the case of therapeutic failure, it is important to evaluate the therapy results and change to a more appropriate antibiotic regime as soon as possible. In the present study, 40 patients with X-ray-verified community-acquired pneumonia were examined and blood specimens were collected before and within 24 h of treatment. Body temperature, C-reactive protein (CRP) and hepatocyte growth factor (HGF) were investigated. Thirty-two patients received an appropriate initial antibiotic therapy regarding clinical outcome, but in 8 patients the treatment was changed because of therapy failure. Changes of HGF levels after 18–24 h of treatment could predict the therapeutic results accurately in 38 of 40 cases (sensitivity 100%, specificity 94%, positive likelihood ratio 16.0). HGF was significantly better to predict therapy outcome than CRP (p < 0.0001).

  • 238.
    Abednazari, Hossin
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Hälsouniversitetet. PEAS Institute, Linköping.
    Brudin, Lars
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
    Almroth, Gabriel
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Njurmedicinska kliniken US.
    Nilsson, Ingela
    Kalmar County Hospital, Sweden.
    Nayeri, Fariba
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Infektionskliniken i Östergötland.
    Hepatocyte growth factor is a reliable marker for efficient anti-bacterial therapy within the first day of treatment2014Ingår i: Advances in Bioscience and Biotechnology, ISSN 2156-8456, E-ISSN 2156-8502, Vol. 5, nr 10, s. 823-830Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Rapid diagnosis and choice of appropriate antibiotic treatment might be life-saving in serious infectious diseases. Still the available markers that can evaluate and monitor the diagnosis and treatment are few. Hepatocyte growth factor (HGF) has been studied as a potent regenerative factor produced and released during injuries such as infectious diseases. Monitoring of HGF levels might predict therapy results better than C-reactive protein (CRP) within the first day of treatment in pneumonia. For further investigation of previous observations we aimed to study HGF as a first-day marker in over-representing infectious diseases in comparison to procalcitonin (PCT), CRP and body temperature. Fifty-one patients with community acquired infectious diseases were included consequently at admittance and the serum samples were collected before and within 18 - 24 hours of treatment. HGF levels decreased significantly in case of efficient antibiotic therapy and HGF was shown to be better than PCT, CRP and body temperature to evaluate treatment. In patients with pneumonia, monitoring of HGF was most reasonable. HGF might be used as a therapeutic marker within the first day of empiric antibiotic treatment during infection.

  • 239.
    Abela, Charles
    Linköpings universitet, Institutionen för beteendevetenskap och lärande.
    Understanding the Dynamics of the Employability Agenda in Further Education Colleges in England: New Cross College - A Case Study2008Självständigt arbete på avancerad nivå (masterexamen), 10 poäng / 15 hpStudentuppsats
    Abstract [en]

    This study explores the dynamic of what happens within a further education college in order to develop an understanding of the cultures, systems and processes that are used to socially construct meaning around work and employability.  It is an inductive approach and is based on a case study of a further education college in South London.  The case study is analysed through the metaphor of an “extended family” and draws on social learning theory which is predicated on meaning and identity being created through social interaction (Wenger, 1998).  What has become apparent from being immersed within that extended family of the College, from interviews with staff and students, interacting in social activities, observing classes and reviewing many of its artefacts is perhaps an unremarkable conclusion.  The work of the family is not primarily about imparting a given set of skills (although that plays an important part) but in the formation of identity: “because learning transforms who we are and what we can do, it is an experience of identity” (Wenger, 1998, p. 215).  A major task for the College is to build self belief in developing the identity of learners and assist them to make new meaning so that they can transact effectively in economic life.  To the extent that one can examine and comprehend the organisational DNA of a further education college there are markers here, genes if you will, that can be passed across generations of learners that adapt and shift to survive in life beyond the boundaries of this community.  This study constructs a narrative around that research experience to respond to that primary research question about how the dynamics of the employability operate within a college.  The answer is partial, limited and perhaps only grabs at a corner of what is really going on within the College.  With those caveats and disclaimers what follows is the story of how a discourse takes root and flourishes within a learning community.  It points to the need to re-set the relationship between FE colleges and government to promote greater coherence between policy and practice.

    Ladda ner fulltext (pdf)
    Understanding the Dynamics of the Employability Agenda in Further Education Colleges in England
  • 240.
    Abele, Wilhelm
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling.
    Starfelt, Simon
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling.
    Framgångsfaktorer vid implementering av artificiell intelligens2020Självständigt arbete på avancerad nivå (magisterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Titel: Framgångsfaktorer vid implementering av artificiell intelligens

    Författare: Wilhelm Abele och Simon Starfelt

    Handledare: Jon Engström

    Nyckelord: Artificiell intelligens (AI), AI-implementering, framgångsfaktorer, hinder, organisation.

    Bakgrund: Artificiell intelligens (AI) har funnits sedan år 1956 men det är först det senaste årtiondet som AI blivit applicerbart inom organisationer. Forskning tyder på att AI har stor värdepotential och företagsledare menar att AI kommer ha stor påverkan på organisatoriska processer. Samtidigt som värdepotentialen ser lovande ut, visar undersökningar att majoriteten av de företag som investerar i AI upplever minimalt eller inget värde från investeringen. Tidigare forskning menar att svårigheterna ligger i implementeringsprocessen av AI och att organisationer bör ha ett affärsmässigt perspektiv för att uppleva värde. Därmed ska de faktorer som påverkar implementeringsprocessen undersökas.

    Syfte: Syftet med studien är att undersöka framgångsfaktorer vid implementering av AI i en organisation. Vidare är syftet att skapa ett ramverk organisationer kan förhålla sig till under implementeringsprocessen av AI.

    Genomförande: Studien är en tentativ flerfallstudie med kvalitativ karaktär. Empirin har samlats in genom intervjuer från sex organisationer av olika karaktär, där de antigen utvecklar AI-system själva eller köpt in externt. Detta för att skapa ett brett perspektiv för vilka framgångsfaktorerna är.

    Slutsats: Studien resulterar i ett ramverk som innefattar de faktorer som anses avgörande för en framgångsrik implementering av AI i en organisation. Ramverket är uppdelat i tre faser: (1) Förberedelsefas, (2) Implementeringsfas och (3) Utvärderingsfas. Framgångsfaktorerna kopplade till en lyckad implementering är: affärsdrivet syfte, involvering av intressenter, datakvalitet- och hantering, kunskapsdelning och organisationsstruktur, samt utvärdering och feedback.

    Ladda ner fulltext (pdf)
    Framgångsfaktorer vid implementering av AI - Abele & Starfelt
  • 241.
    Abelius, M
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Pediatrik. Linköpings universitet, Hälsouniversitetet.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk immunologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Berg, Göran
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Matthiesen, Leif
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Nilsson, L J
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Pediatrik. Linköpings universitet, Hälsouniversitetet.
    Immunological interactions between mother and child: a characterisation of Th1-and Th2-like chemokines during pregnancy, postpartum and childhood in JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol 90, issue 2, pp 170-1712011Ingår i: JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Elsevier , 2011, Vol. 90, nr 2, s. 170-171Konferensbidrag (Refereegranskat)
    Abstract [en]

    n/a

  • 242. Beställ onlineKöp publikationen >>
    Abelius, Martina
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet.
    Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring2014Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    Background: Pregnancy and allergic disease have both been postulated as T-helper 2 (Th2) phenomena. Thus, the increased propensity of allergic mothers to mount Th2-responses might generate favourable effects on the maintenance of pregnancy, but might also be unfavorable, as fetal exposure to a strong Th2 environment could influence the immune development in the offspring to a Th2-like phenotype, favouring IgE production and possibly allergy development later in life. The influence of the intrauterine environment on the immunity and allergy development in the offspring needs to be further investigated.

    Aim: The aim of this thesis was to explore the Th1/Th2 balance in allergic and non-allergic women during pregnancy and its influence on the shaping of the Th1/Th2 profile in the neonate and the development of allergic diseases in the offspring.

    Material and methods: The study group included 20 women with and 36 women without allergic symptoms followed during pregnancy (gestational week 10-12, 15-16, 25, 35, 39) and 2 and 12 months postpartum, and their children followed from birth to 6 years of age. The circulating Th1-like chemokines CXCL9, CXCL10, CXCL11, Th2-like chemokines CCL17, CCL18 and CCL22, and the allergen-induced secretion of interleukin-4 (IL-4), IL-5, IL-10, IL-13, Interferon-γ (IFN-γ), CXCL10 and CCL17 were measured by Luminex and ELISA. The allergen-specific and total IgE levels were quantified using ImmunoCAP Technology. mRNA expression of Th1-, Th2-, Treg- and Th17-associated genes were measured by PCR arrays and real-time PCR.

    Results: We found that sensitised women with allergic symptoms had increased total IgE levels and birch- and cat-induced IL-5, IL-13 and CCL17 responses during pregnancy as compared with postpartum. The non-sensitised women without allergic symptoms had elevated cat-induced IL-5 and IL-13 responses and lower birch- and cat-induced IFN-γ during pregnancy, but similar IgE levels as compared with postpartum.

    Maternal total IgE levels during and after pregnancy correlated with cord blood (CB) IgE and CCL22 levels (regardless of maternal allergy status). Circulating CXCL11, CCL18 and CCL22 levels during pregnancy and postpartum correlated with the corresponding chemokine levels in the offspring at various time points during childhood. Maternal IL-5 expression in peripheral blood mononuclear cells (PBMC) was associated with neonatal Galectin-1, and placental p35 expression was negatively associated with neonatal Tbx21 expression. Increased mRNA expression of CCL22 in cord blood mononuclear cells (CBMC), and increased CCL17 and CCL22 levels in CB were observed in children later developing allergic symptoms and sensitisation as compared with children who did not. Development of allergic symptoms and sensitisation were associated with increased total IgE, CCL17, CCL18 and CCL22 levels during childhood.

    Conclusions: Maternal allergy was associated with a pronounced Th2 deviation during pregnancy, shown as increased total IgE levels and birch- and cat-induced IL-5, IL-13 and CCL17 responses during pregnancy, possibly exposing their fetuses to a particular strong Th2 environment during gestation.

    Correlations were shown between the maternal immunity during pregnancy and the offspring’s immunity at birth and later during childhood, indicating an interplay between the maternal and fetal immunity.

    Allergy development during the first 6 years of life was associated with a marked Th2 deviation at birth and a delayed down-regulation of this Th2-skewed immunity during childhood.

    Delarbeten
    1. Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy
    Öppna denna publikation i ny flik eller fönster >>Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy
    Visa övriga...
    2009 (Engelska)Ingår i: JOURNAL OF REPRODUCTIVE IMMUNOLOGY, ISSN 0165-0378, Vol. 81, nr 1, s. 82-88Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Type 2 T-helper cell (Th2)-skewed immunity is associated with successful pregnancy and the ability to easily direct immune responses to a Th2-polarised profile may be an evolutionary benefit. The Th2-like immunity associated with allergic disease might generate favourable effects for the maintenance of pregnancy, but could also promote development of Th2-like immune responses and allergic disease in the offspring. The aim of this study was to explore, by using IgE as a stable proxy for Th2, the Th1/Th2 balance in allergic and non-allergic women by measuring allergen-specific and total IgE antibody levels in plasma during pregnancy and after delivery. Specific and total IgE antibody levels were determined by ImmunoCAP technology at five occasions during pregnancy (gestational weeks 10-12, 15-16, 25, 35 and 39), as well as at 2 and 12 months after delivery. Thirty-six women without and 20 women with allergic symptoms were included, of whom 13 were sensitised with allergic symptoms and 30 were non-sensitised without allergic symptoms. The levels of total IgE, but not allergen-specific IgE, were increased during early pregnancy when compared to 12 months after delivery in the sensitised women with allergic symptoms, but not in the non-sensitised women without allergic symptoms (pandlt;0.01). This increase in total IgE levels during early pregnancy only in the sensitised women with allergic symptoms indicates that allergy is associated with an enhanced Th2 deviation during pregnancy.

    Nyckelord
    Allergy, IgE, Phadiatop, Pregnancy, Th2
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-19894 (URN)10.1016/j.jri.2009.04.003 (DOI)
    Anmärkning

    Original Publication: Martina Sandberg, Anne Frykman, Yvonne Jonsson, Marie Persson, Jan Ernerudh, Göran Berg, Leif Matthiesen, Christina Ekerfelt and Maria Jenmalm, Total and allergen-specific IgE levels during and after pregnancy in relation to maternal allergy, 2009, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, (81), 1, 82-88. http://dx.doi.org/10.1016/j.jri.2009.04.003 Copyright: Elsevier Science B.V., Amsterdam. http://www.elsevier.com/

    Tillgänglig från: 2009-09-09 Skapad: 2009-08-14 Senast uppdaterad: 2021-12-29Bibliografiskt granskad
    2. High cord blood levels of the T-helper 2-associated chemokines CCL17 and CCL22 precede allergy development during the first 6 years of life
    Öppna denna publikation i ny flik eller fönster >>High cord blood levels of the T-helper 2-associated chemokines CCL17 and CCL22 precede allergy development during the first 6 years of life
    Visa övriga...
    2011 (Engelska)Ingår i: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 70, nr 5, s. 495-500Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Exposure to a strong T-helper 2 (Th2)-like environment during fetal development may promote allergy development. Increased cord blood (CB) levels of the Th2-associated chemokine CCL22 were associated with allergy development during the first 2 y of life. The aim of the present study was to determine whether CB Th1- and Th2-associated chemokine levels are associated with allergy development during the first 6 y of life, allowing assessment of respiratory allergic symptoms usually developing in this period. The CB levels of cytokines, chemokines, and total IgE were determined in 56 children of 20 women with allergic symptoms and 36 women without allergic symptoms. Total IgE and allergen-specific IgE antibody levels were quantified at 6, 12, 24 mo, and 6 y of age. Increased CB CCL22 levels were associated with development of allergic sensitization and asthma and increased CCL17 levels with development of allergic symptoms, including asthma. Sensitized children with allergic symptoms showed higher CB CCL17 and CCL22 levels and higher ratios between these Th2-associated chemokines and the Th1-associated chemokine CXCL10 than nonsensitized children without allergic symptoms. A pronounced Th2 deviation at birth, reflected by increased CB CCL17 and CCL22 levels, and increased CCL22/CXCL10 and CCL17/CXCL10 ratios might promote allergy development later in life.

    Nyckelord
    AD, atopic dermatitis, ARC, allergic rhinoconjunctivitis, CB, cord blood, SPT, skin prick test, Th, T-helper
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-74499 (URN)10.1203/PDR.0b013e31822f2411 (DOI)000296121100010 ()21796021 (PubMedID)
    Tillgänglig från: 2012-01-30 Skapad: 2012-01-30 Senast uppdaterad: 2021-12-29
    3. Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy
    Öppna denna publikation i ny flik eller fönster >>Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy
    Visa övriga...
    2014 (Engelska)Ingår i: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 25, nr 4, s. 387-393Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Background: The influence of the intra-uterine environment on the immunity and allergy development in the offspring is unclear. We aimed to investigate (i) whether the pregnancy magnifies the Th2 immunity in allergic and non-allergic women, (ii) whether the maternal chemokine levels during pregnancy influenced the offspring’s chemokine levels during childhood and (iii) the relationship between circulating Th1/Th2-associated chemokines and allergy in mothers and children.

    Methods: The Th1-associated chemokines CXCL9, CXCL10, CXCL11, and the Th2- associated chemokines CCL17, CCL18 and CCL22 were quantified by Luminex and ELISA in 20 women with and 36 women without allergic symptoms at gestational week (gw) 10–12, 15–16, 25, 35, 39 and 2 and 12 months post-partum and in their children at birth, 6, 12, 24 months and 6 yr of age. Total IgE levels were measured using ImmunoCAP Technology.

    Results: The levels of the Th2-like chemokines were not magnified by pregnancy. Instead decreased levels were shown during pregnancy (irrespectively of maternal allergy status) as compared to post-partum. In the whole group, the Th1-like chemokine levels were higher at gw 39 than during the first and second trimester and post-partum. Maternal CXCL11, CCL18 and CCL22 levels during and after pregnancy correlated with the corresponding chemokines in the offspring during childhood. Increased CCL22 and decreased CXCL10 levels in the children were associated with sensitisation and increased CCL17 levels with allergic symptoms during childhood. Maternal chemokine levels were not associated with maternal allergic disease.

    Conclusions: Allergic symptoms and sensitisation were associated with decreased Th1-and increased Th2-associated chemokine levels during childhood, indicating a Th2 shift in the allergic children, possibly influenced by the maternal immunity during pregnancy.

    Ort, förlag, år, upplaga, sidor
    John Wiley & Sons, 2014
    Nyckelord
    Allergy; CCL17; CCL22; chemokines; pregnancy; Th2
    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-106218 (URN)10.1111/pai.12235 (DOI)000338037100013 ()
    Tillgänglig från: 2014-04-29 Skapad: 2014-04-29 Senast uppdaterad: 2021-12-29Bibliografiskt granskad
    4. Gene expression in placenta, peripheral and cord blood mononuclear cells from allergic and non-allergic women
    Öppna denna publikation i ny flik eller fönster >>Gene expression in placenta, peripheral and cord blood mononuclear cells from allergic and non-allergic women
    Visa övriga...
    2014 (Engelska)Manuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    Background: The influence of maternal allergy on the development of immune responses and allergy in the offspring is not understood.

    Objective: To investigate (i) if maternal allergy influences the gene expression locally in placenta, systemically in peripheral blood mononuclear cells (PBMC) and fetally in cord blood mononuclear cells (CBMC), (ii) if the gene expression in the placenta and PBMC influences the gene expression in CBMC and (iii) how the gene expression at birth relates to allergy development during  childhood.

    Methods: A real-time PCR array was used to quantify forty immune regulatory genes in placenta, PBMC (gestational week 39) and in CBMC from 7 allergic and 12 non-allergic women and their offspring. Furthermore, quantitative real-time PCR was used to measure mRNA expression of Tbx21, GATA-3, Foxp3, RORC and CCL22 in CBMC, selected based on present PCR array results and previous protein findings in cord blood, in 13 children who developed and 11 children who did not develop allergy during childhood.

    Results: The gene expression profile in the placenta revealed a T-helper (Th) 2-/anti-inflammatory environment as compared with gene expression systemically, in PBMC. Maternal allergy was associated with increased expression of p35 in PBMC and CBMC and p40 in placenta. Placental p35 expression correlated with fetal Tbx21 expression (Rho=-0.88, p<0.001) and maternal IL-5 expression in PBMC with fetal Galectin-1 (Rho=0.91, p<0.001) expression. Allergy development in the children was preceded by high mRNA expression of the Th2-associated chemokine CCL22 at birth.

    Conclusion and clinical relevance: Gene expression locally and systemically during pregnancy influenced the offspring’s gene expression at birth, indicating an interplay between maternal and fetal immunity. Children developing allergy during childhood had an increased expression of the Th2-associated chemokine CCL22 at birth, indicating a Th2 skewing before disease onset. Maternal allergy was not associated with a Th2-dominance in placenta, PBMC or CBMC.

    Nationell ämneskategori
    Medicin och hälsovetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-106219 (URN)
    Tillgänglig från: 2014-04-29 Skapad: 2014-04-29 Senast uppdaterad: 2021-12-29Bibliografiskt granskad
    Ladda ner fulltext (pdf)
    Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring
    Ladda ner (pdf)
    omslag
  • 243.
    Abelius, Martina
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet.
    Enke, Uta
    University Hospital Jena, Germany.
    Varosi, Frauke
    University Hospital Jena, Germany.
    Hoyer, Heike
    University Hospital Jena, Germany.
    Schleussner, Ekkehard
    University Hospital Jena, Germany.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet.
    Markert, Udo R.
    University Hospital Jena, Germany.
    Placental immune response to apple allergen in allergic mothers2014Ingår i: Journal of Reproductive Immunology, ISSN 0165-0378, E-ISSN 1872-7603, Vol. 106, s. 100-109Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero, but little is known about allergen-induced placental cytokine and chemokine release. The release of several cytokines and chemokines from placenta tissue after exposure to mast cell degranulator compound 48/80 or apple allergen in placentas from allergic and healthy mothers was to be analysed. Four placentas from women with apple allergy and three controls were applied in a placental perfusion model with two separate cotyledons simultaneously perfused with and without apple allergen (Mal d 1). Two control placentas were perfused with compound 48/80. In outflow, histamine was quantified spectrophotofluorometrically, IL-2, IL-4, IL-6, IL-10, TNF and IFN-gamma by a cytometric multiplex bead array and IL-13 and CXCL10, CXCL11, CCL17 and CCL22 with an in-house multiplex Luminex assay. Compound 48/80 induced a rapid release of histamine, CXCL10, CXCL11, CCL17 and CCL22, but not of the other factors. Apple allergen induced a time-dependent release of IL-6 and TNF, but not of histamine, in placentas of women with apple allergy compared with the unstimulated cotyledon. CCL17 levels were slightly increased after allergen stimulation in control placentas. Allergens can induce placental cytokines and chemokines distinctly in allergic and healthy mothers. These mediators may affect the prenatal development of the immune system and modify the risk of diseases related to immune disorders in childhood such as allergies.

    Ladda ner fulltext (pdf)
    fulltext
  • 244.
    Abelius, Martina
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Jedenfalk, Malin
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Janefjord, Camilla
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Berg, Göran
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Matthiesen, Leif
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, Kvinnokliniken i Linköping. Helsingborg Hospital, Sweden.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Pregnancy modulates the allergen-induced cytokine production differently in allergic and non-allergic women2017Ingår i: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 28, nr 8, s. 818-824Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The immunological environment during pregnancy may differ between allergic and non-allergic women. This study investigates the effect of maternal allergy on the allergen-induced cytokine and chemokine levels and whether pregnancy modulates these immune responses differently in allergic and non-allergic women. Methods: The birch-, cat-, phytohemagglutinin- and tetanus toxoid-induced interferon-gamma(IFN-gamma), interleukin (IL)-4, IL-5, IL-10, IL-13, the T-helper 1 (Th1)-associated chemokine CXCL10 and the Th2-associated chemokine CCL17 levels were quantified in 20 women with allergic symptoms (sensitized, n=13) and 36 women without allergic symptoms (non-sensitized, n=30) at gestational weeks 10-12, 15-16, 25, 35 and 2 and 12months post-partum. Results: Birch-, but not cat-induced, IL-5, IL-13 and CCL17 levels were increased during pregnancy as compared to post-partum in the sensitized women with allergic symptoms. In contrast, cat-, but not birch-induced, IL-5 and IL-13 levels were increased during pregnancy as compared to post-partum in the non-sensitized women without allergic symptoms. Furthermore, IFN-gamma secretion was increased in the first and decreased in the second and third trimesters in response to birch and decreased in the third trimester in response to cat as compared to post-partum in the non-sensitized women without allergic symptoms. Increased allergen-induced IL-4, IL-5 and IL-13 levels were associated with allergic symptoms and sensitization. Conclusions: Pregnancy had a clear effect on the allergen-induced IL-5, IL-13, CCL17, IFN-gamma and CXCL10 production, with distinct enhanced Th2-responses to birch in the allergic group and to cat in the non-allergic group.

    Ladda ner fulltext (pdf)
    fulltext
  • 245.
    Abelius, Martina S
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Pediatrik. Linköpings universitet, Hälsouniversitetet.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk immunologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Berg, Göran
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Matthiesen, Leif
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Nilsson, Lennart
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Pediatrik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Pediatrik. Linköpings universitet, Hälsouniversitetet.
    High cord blood levels of the T-helper 2-associated chemokines CCL17 and CCL22 precede allergy development during the first 6 years of life2011Ingår i: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 70, nr 5, s. 495-500Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Exposure to a strong T-helper 2 (Th2)-like environment during fetal development may promote allergy development. Increased cord blood (CB) levels of the Th2-associated chemokine CCL22 were associated with allergy development during the first 2 y of life. The aim of the present study was to determine whether CB Th1- and Th2-associated chemokine levels are associated with allergy development during the first 6 y of life, allowing assessment of respiratory allergic symptoms usually developing in this period. The CB levels of cytokines, chemokines, and total IgE were determined in 56 children of 20 women with allergic symptoms and 36 women without allergic symptoms. Total IgE and allergen-specific IgE antibody levels were quantified at 6, 12, 24 mo, and 6 y of age. Increased CB CCL22 levels were associated with development of allergic sensitization and asthma and increased CCL17 levels with development of allergic symptoms, including asthma. Sensitized children with allergic symptoms showed higher CB CCL17 and CCL22 levels and higher ratios between these Th2-associated chemokines and the Th1-associated chemokine CXCL10 than nonsensitized children without allergic symptoms. A pronounced Th2 deviation at birth, reflected by increased CB CCL17 and CCL22 levels, and increased CCL22/CXCL10 and CCL17/CXCL10 ratios might promote allergy development later in life.

    Ladda ner fulltext (pdf)
    fulltext
  • 246.
    Abelius, Martina S
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Janefjord, Camilla
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Berg, Göran
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Matthiesen, Leif
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, Kvinnokliniken i Linköping. Helsingborg Hospital, Helsingborg.
    Duchén, Karel
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
    Nilsson, Lennart J
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    The Placental Immune Milieu is Characterized by a Th2- and Anti-Inflammatory Transcription Profile, Regardless of Maternal Allergy, and Associates with Neonatal Immunity2015Ingår i: American Journal of Reproductive Immunology, ISSN 1046-7408, E-ISSN 1600-0897, Vol. 73, nr 5, s. 445-459Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    PROBLEM: How maternal allergy affects the systemic and local immunological environment during pregnancy and the immune development of the offspring is unclear.

    METHOD OF STUDY: Expression of 40 genes was quantified by PCR arrays in placenta, peripheral blood mononuclear cells (PBMC), and cord blood mononuclear cells (CBMC) from 7 allergic and 12 non-allergic women and their offspring.

    RESULTS: Placental gene expression was dominated by a Th2-/anti-inflammatory profile, irrespectively of maternal allergy, as compared to gene expression in PBMC. p35 expression in placenta correlated with fetal Tbx21 (ρ = -0.88, P < 0.001) and IL-5 expression in PBMC with fetal galectin1 (ρ = 0.91, P < 0.001). Increased expression of Th2-associated CCL22 in CBMC preceded allergy development.

    CONCLUSIONS: Gene expression locally and systemically during pregnancy was partly associated with the offspring's gene expression, possibly indicating that the immunological milieu is important for fetal immune development. Maternal allergy was not associated with an enhanced Th2 immunity in placenta or PBMC, while a marked prenatal Th2 skewing, shown as increased CCL22 mRNA expression, might contribute to postnatal allergy development.

    Ladda ner fulltext (pdf)
    fulltext
  • 247.
    Abelius, Martina S
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet.
    Janefjord, Camilla
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Berg, Göran
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Matthiesen, Leif
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Duchén, Karel
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Nilsson, Lennart
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Allergicentrum US.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet.
    Gene expression in placenta, peripheral and cord blood mononuclear cells from allergic and non-allergic women2014Manuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    Background: The influence of maternal allergy on the development of immune responses and allergy in the offspring is not understood.

    Objective: To investigate (i) if maternal allergy influences the gene expression locally in placenta, systemically in peripheral blood mononuclear cells (PBMC) and fetally in cord blood mononuclear cells (CBMC), (ii) if the gene expression in the placenta and PBMC influences the gene expression in CBMC and (iii) how the gene expression at birth relates to allergy development during  childhood.

    Methods: A real-time PCR array was used to quantify forty immune regulatory genes in placenta, PBMC (gestational week 39) and in CBMC from 7 allergic and 12 non-allergic women and their offspring. Furthermore, quantitative real-time PCR was used to measure mRNA expression of Tbx21, GATA-3, Foxp3, RORC and CCL22 in CBMC, selected based on present PCR array results and previous protein findings in cord blood, in 13 children who developed and 11 children who did not develop allergy during childhood.

    Results: The gene expression profile in the placenta revealed a T-helper (Th) 2-/anti-inflammatory environment as compared with gene expression systemically, in PBMC. Maternal allergy was associated with increased expression of p35 in PBMC and CBMC and p40 in placenta. Placental p35 expression correlated with fetal Tbx21 expression (Rho=-0.88, p<0.001) and maternal IL-5 expression in PBMC with fetal Galectin-1 (Rho=0.91, p<0.001) expression. Allergy development in the children was preceded by high mRNA expression of the Th2-associated chemokine CCL22 at birth.

    Conclusion and clinical relevance: Gene expression locally and systemically during pregnancy influenced the offspring’s gene expression at birth, indicating an interplay between maternal and fetal immunity. Children developing allergy during childhood had an increased expression of the Th2-associated chemokine CCL22 at birth, indicating a Th2 skewing before disease onset. Maternal allergy was not associated with a Th2-dominance in placenta, PBMC or CBMC.

  • 248.
    Abelius, Martina S
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet.
    Lempinen, Esma
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet.
    Lindblad, Karin
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Berg, Göran
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Matthiesen, Leif
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
    Nilsson, Lennart
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Allergicentrum US.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet.
    Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy2014Ingår i: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 25, nr 4, s. 387-393Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The influence of the intra-uterine environment on the immunity and allergy development in the offspring is unclear. We aimed to investigate (i) whether the pregnancy magnifies the Th2 immunity in allergic and non-allergic women, (ii) whether the maternal chemokine levels during pregnancy influenced the offspring’s chemokine levels during childhood and (iii) the relationship between circulating Th1/Th2-associated chemokines and allergy in mothers and children.

    Methods: The Th1-associated chemokines CXCL9, CXCL10, CXCL11, and the Th2- associated chemokines CCL17, CCL18 and CCL22 were quantified by Luminex and ELISA in 20 women with and 36 women without allergic symptoms at gestational week (gw) 10–12, 15–16, 25, 35, 39 and 2 and 12 months post-partum and in their children at birth, 6, 12, 24 months and 6 yr of age. Total IgE levels were measured using ImmunoCAP Technology.

    Results: The levels of the Th2-like chemokines were not magnified by pregnancy. Instead decreased levels were shown during pregnancy (irrespectively of maternal allergy status) as compared to post-partum. In the whole group, the Th1-like chemokine levels were higher at gw 39 than during the first and second trimester and post-partum. Maternal CXCL11, CCL18 and CCL22 levels during and after pregnancy correlated with the corresponding chemokines in the offspring during childhood. Increased CCL22 and decreased CXCL10 levels in the children were associated with sensitisation and increased CCL17 levels with allergic symptoms during childhood. Maternal chemokine levels were not associated with maternal allergic disease.

    Conclusions: Allergic symptoms and sensitisation were associated with decreased Th1-and increased Th2-associated chemokine levels during childhood, indicating a Th2 shift in the allergic children, possibly influenced by the maternal immunity during pregnancy.

    Ladda ner fulltext (pdf)
    Th2-like chemokine levels are increased in allergic children and influenced by maternal immunity during pregnancy
  • 249.
    Abellán, C.
    et al.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Acín, A.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain / ICREA - Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
    Alarcón, A.
    Millennium Institute for Research in Optics, Universidad de Concepción, Concepción, Chile; Departamento de Ingeniería Eléctrica, Universidad de Concepción, Concepción, Chile.
    Alibart, O.
    Université Côte d’Azur, CNRS UMR 7010, Institut de Physique de Nice (INPHYNI), Nice, France.
    Andersen, C. K.
    Department of Physics, ETH Zurich, Zurich, Switzerland.
    Andreoli, F.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Beckert, A.
    Department of Physics, ETH Zurich,, Zurich, Switzerland.
    Beduini, F. A.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Bendersky, A.
    Departamento de Computación, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires; Instituto de Investigación en Ciencias de la Comunicación (ICC), CONICET, Buenos Aires, Argentina.
    Bentivegna, M.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Bierhorst, P.
    National Institute of Standards and Technology, Boulder, CO, USA.
    Burchardt, D.
    Ludwig-Maximilians-Universität, Munich, Germany.
    Cabello, A.
    Departamento de Física Aplicada II, Universidad de Sevilla, Seville, Spain.
    Cariñe, J.
    Millennium Institute for Research in Optics, Universidad de Concepción, Universidad de Concepción, Concepción, Chile.
    Carrasco, S.
    ICFO - Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain.
    Carvacho, G.
    Dipartimento di Fisica, Sapienza Università di Roma, Rome, Italy.
    Cavalcanti, D.
    Chaves, R.
    Cortés-Vega, J.
    Cuevas, A.
    Delgado, A.
    de Riedmatten, H.
    Eichler, C.
    Farrera, P.
    Fuenzalida, J.
    García-Matos, M.
    Garthoff, R.
    Gasparinetti, S.
    Gerrits, T.
    Ghafari Jouneghani, F.
    Glancy, S.
    Gómez, E. S.
    González, P.
    Guan, J. -Y.
    Handsteiner, J.
    Heinsoo, J.
    Heintze, G.
    Hirschmann, A.
    Jiménez, O.
    Kaiser, F.
    Knill, E.
    Knoll, L. T.
    Krinner, S.
    Kurpiers, P.
    Larotonda, M. A.
    Larsson, Jan-Åke
    Linköpings universitet, Institutionen för systemteknik, Informationskodning. Linköpings universitet, Tekniska fakulteten.
    Lenhard, A.
    Li, H.
    Li, M. -H.
    Lima, G.
    Liu, B.
    Liu, Y.
    López Grande, I. H.
    Lunghi, T.
    Ma, X.
    Magaña-Loaiza, O. S.
    Magnard, P.
    Magnoni, A.
    Martí­-Prieto, M.
    Martínez, D.
    Mataloni, P.
    Mattar, A.
    Mazzera, M.
    Mirin, R. P.
    Mitchell, M. W.
    Nam, S.
    Oppliger, M.
    Pan, J. -W.
    Patel, R. B.
    Pryde, G. J.
    Rauch, D.
    Redeker, K.
    Rieländer, D.
    Ringbauer, M.
    Roberson, T.
    Rosenfeld, W.
    Salathé, Y.
    Santodonato, L.
    Sauder, G.
    Scheidl, T.
    Schmiegelow, C. T.
    Sciarrino, F.
    Seri, A.
    Shalm, L. K.
    Shi, S. -C
    Slussarenko, S.
    Stevens, M. J.
    Tanzilli, S.
    Toledo, F.
    Tura, J.
    Ursin, R.
    Vergyris, P.
    Verma, V. B.
    Walter, T.
    Wallraff, A.
    Wang, Z.
    Weinfurter, H.
    Weston, M. M.
    White, A. G.
    Wu, C.
    Xavier, Guilherme B.
    Linköpings universitet, Institutionen för systemteknik, Informationskodning. Linköpings universitet, Tekniska fakulteten.
    You, L.
    Yuan, X.
    Zeilinger, A.
    Zhang, Q.
    Zhang, W.
    Zhong, J.
    Challenging Local Realism with Human Choices2018Ingår i: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 557, s. 212-216Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A Bell test is a randomized trial that compares experimental observations against the philosophical worldview of local realism , in which the properties of the physical world are independent of our observation of them and no signal travels faster than light. A Bell test requires spatially distributed entanglement, fast and high-efficiency detection and unpredictable measurement settings. Although technology can satisfy the first two of these requirements, the use of physical devices to choose settings in a Bell test involves making assumptions about the physics that one aims to test. Bell himself noted this weakness in using physical setting choices and argued that human 'free will' could be used rigorously to ensure unpredictability in Bell tests. Here we report a set of local-realism tests using human choices, which avoids assumptions about predictability in physics. We recruited about 100,000 human participants to play an online video game that incentivizes fast, sustained input of unpredictable selections and illustrates Bell-test methodology. The participants generated 97,347,490 binary choices, which were directed via a scalable web platform to 12 laboratories on five continents, where 13 experiments tested local realism using photons, single atoms, atomic ensembles and superconducting devices. Over a 12-hour period on 30 November 2016, participants worldwide provided a sustained data flow of over 1,000 bits per second to the experiments, which used different human-generated data to choose each measurement setting. The observed correlations strongly contradict local realism and other realistic positions in bi-partite and tri-partite 12 scenarios. Project outcomes include closing the 'freedom-of-choice loophole' (the possibility that the setting choices are influenced by 'hidden variables' to correlate with the particle properties), the utilization of video-game methods for rapid collection of human-generated randomness, and the use of networking techniques for global participation in experimental science.

    Ladda ner fulltext (pdf)
    Challenging local realism with human choices
  • 250.
    Abelow, Alexis
    et al.
    University of Utah, Salt Lake City, USA.
    Persson, Kristin
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
    Jager, Edwin
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska högskolan.
    Berggren, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
    Zharov, Ilya
    University of Utah, Salt Lake City, USA.
    Electroresponsive Nanoporous Membranes by Coating Anodized Alumina with Poly(3,4-ethylenedioxythiophone) and Polypyrrole2014Ingår i: Macromolecular materials and engineering, ISSN 1438-7492, E-ISSN 1439-2054, Vol. 299, nr 2, s. 190-197Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Electrically-active nanoporous membranes are prepared by coating the surface of anodized alumina with electroactive polymers using vapor phase polymerization with four combinations of conjugated polymers and doping ions: poly(3,4-ethylenedioxythiophone) and polypyrrole, FeCl3 and FeTs3. The permeability of the polymer-coated membranes is measured as a function of the applied electric potential. A reversible three-fold increase is found in molecular flux of a neutral dye for membranes in oxidized state compared to that in the reduced state. After analyzing various factors that may affect the molecular transport through these membranes, it is concluded that the observed behavior results mostly from swelling/deswelling of the polymers and from the confinement of the polymers inside the nanopores.

2345678 201 - 250 av 119932
RefereraExporteraLänk till träfflistan
Permanent länk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf