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  • 251.
    Tham, Richard
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Möller, Claes
    Linköping University.
    Niklasson, Magnus
    Östergötlands Läns Landsting.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Vestibulotoxicity of organic solvents1991In: Fourth international conference on combined effect of environmental factors / [ed] Laurence D. Fechter, Johns Hopkins University , 1991, p. 101-105Conference paper (Other academic)
  • 252.
    Tham, Richard
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Niklasson, Magnus
    Östergötlands Läns Landsting.
    Ödkvist, Lars
    Östergötlands Läns Landsting.
    Lesions of the commisural vestibular fibers in rats: The effect on the vestibulo- and opto-oculomotor system1988Conference paper (Other academic)
  • 253.
    Tham, Richard
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Ödkvist, Lars
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Norlander, Björn
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Hydén, Dag
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Aschan, Gunnar
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    The influence of trichlorethylene and related drugs on the vestibular system1979In: Acta Pharmacologica et Toxicologica, ISSN 0001-6683, Vol. 44, no 5, p. 336-342Article in journal (Refereed)
    Abstract [en]

    A previously described experimental model for studying the effect of industrial solvents on the vestibular system of rabbits has been applied to trichloroethylene. Estimation of trichloroethylene and its metabolites in blood and cerebrospinal fluid was performed by gas chromatography. Vestibular function was studied by recording nystagmus, induced by positional changes or accelerated rotation. At blood levels of trichloroethylene above 30 p.p.m. “positional nystagmus” develops. Two metabolites of trichloroethylene, chloral hydrate and trichloro-ethanol, which are known as central nervous system (CNS) depressants, did not induce this abnormal nystagmus. However, α-chloralose, a derivative of chloral hydrate, induced positional nystagmus and also a markedly exaggerated nystagmus developed during rotatory acceleration. It is suggested that solvents like trichloroethylene elicit vestibular disturbances by stimulation of central subcortical vestibulo-oculomotor connections. The stimulation may be caused by a blockage of inhibitory systems.

  • 254.
    van Esch, T.E.M.
    et al.
    Academic Medical Center, NL-Amsterdam.
    Lutman, M.E.
    University of Southampton, UK-Southampton.
    Vorman, M.
    Hörzentrum Oldenburg GmbH, D- Oldenburg.
    Lyzenga, J.
    VU Medical Center, NL- Amsterdam .
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Otorhinolaryngology in Linköping.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Athalye, S.P.
    Univ Southampton, Inst Sound & Vibrat Res, Southampton SO9 5NH, Hants, England.
    Houtgast, T.
    Free Univ Amsterdam Hosp, Dept ENT Audiol, Amsterdam, Netherlands.
    Kollmeier, B
    Hörzentrum Oldenburg GmbH, D- Oldenburg.
    Dreschler, W. A.,
    Academic Medical Center, NL-Amsterdam.
    Relations between psychophysical measures of spatial hearing and self-reported spatial- hearing abilities2015In: International Journal of Audiology, ISSN 1499-2027, E-ISSN 1708-8186, Vol. 54, no 3, p. 182-189Article in journal (Refereed)
    Abstract [en]

    Objective: The aim of the present study was to investigate how well the virtual psychophysical measures of spatial hearing from the preliminary auditory profile predict self-reported spatial-hearing abilities. Design: Virtual spatial-hearings tests (conducted unaided, via headphones) and a questionnaire were administered in five centres in Germany, the Netherlands, Sweden, and the UK. Correlations and stepwise linear regression models were calculated among a group of hearing-impaired listeners. Study sample: Thirty normal-hearing listeners aged 19–39 years, and 72 hearing-impaired listeners aged 22–91 years with a broad range of hearing losses, including asymmetrical and mixed hearing losses. Results: Several significant correlations (between 0.24 and 0.54) were found between results of virtual psychophysical spatial-hearing tests and self-reported localization abilities. Stepwise linear regression analyses showed that the minimum audible angle (MAA) test was a significant predictor for self-reported localization abilities (5% extra explained variance), and the spatial speech reception threshold (SRT) benefit test for self-reported listening to speech in spatial situations (6% extra explained variance). Conclusions: The MAA test and spatial SRT benefit test are indicative measures of everyday binaural functioning. The binaural SRT benefit test was not found to predict self-reported spatial-hearing abilities. Read More: http://informahealthcare.com/doi/abs/10.3109/14992027.2014.953216

  • 255.
    van Esch, Thamar E. M.
    et al.
    Academic Medical Centre, Amsterdam, The Netherlands.
    Kollmeier, Birger
    Hörzentrum Oldenburg GmbH, Germany.
    Vormann, Matthias
    Hörzentrum Oldenburg GmbH, Germany.
    Lyzenga, Johannes
    Free University Hospital, The Netherlands.
    Houtgast, Tammo
    Free University Hospital, The Netherlands.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Athalye, Sheetal P.
    University of Southampton, UK.
    Lutman, Mark E
    University of Southampton, UK.
    Dreschler, Wouter A.
    Academic Medical Centre, Amsterdam, The Netherlands.
    Evaluation of the preliminary auditory profile test battery in an international multi-centre study2013In: International Journal of Audiology, ISSN 1499-2027, E-ISSN 1708-8186, Vol. 52, no 5, p. 305-321Article in journal (Refereed)
    Abstract [en]

    Objective: This paper describes the composition and international multi-centre evaluation of a battery of tests termed the preliminary auditory profile. It includes measures of loudness perception, listening effort, speech perception, spectral and temporal resolution, spatial hearing, self-reported disability and handicap, and cognition. Clinical applicability and comparability across different centres are investigated. Design: Headphone tests were conducted in five centres divided over four countries. Effects of test-retest, ear, and centre were investigated. Results for normally-hearing (NH) and hearing-impaired (HI) listeners are presented. Study sample: Thirty NH listeners aged 19-39 years, and 72 HI listeners aged 22-91 years with a broad range of hearing losses were included. Results: Test-retest reliability was generally good and there were very few right/left ear effects. Results of all tests were comparable across centres for NH listeners after baseline correction to account for necessary differences between test materials. For HI listeners, results were comparable across centres for the language-independent tests. Conclusions: The auditory profile forms a clinical test battery that is applicable in four different languages. Even after baseline correction, differences between test materials have to be taken into account when interpreting results of language-dependent tests in HI listeners.

  • 256.
    Wass, Malin
    et al.
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Ibertsson, Tina
    Lund University, Sweden.
    Lyxell, Björn
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Sahlen, Birgitta
    Lund University, Sweden.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Mäki-Torkko, Elina
    Department of Otolaryngology/Section of Audiology, Linköping University Hospital, Sweden.
    Cognitive and linguistic skills in Swedish children with cochlear implants - measures of accuracy and latency as indicators of development2008In: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 49, no 6, p. 559-576Article in journal (Refereed)
    Abstract [en]

    The purpose of the present study was to examine working memory (WM) capacity, lexical access and phonological skills in 19 children with cochlear implants (CI) (5;7-13;4 years of age) attending grades 0-2, 4, 5 and 6 and to compare their performance with 56 children with normal hearing. Their performance was also studied in relation to demographic factors. The findings indicate that children with CI had visuospatial WM capacities equivalent to the comparison group. They had lower performance levels on most of the other cognitive tests. Significant differences between the groups were not found in all grades and a number of children with CI performed within 1 SD of the mean of their respective grade-matched comparison group on most of the cognitive measures. The differences between the groups were particularly prominent in tasks of phonological WM. The results are discussed with respect to the effects of cochlear implants on cognitive development.

  • 257.
    Wass, Malin
    et al.
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Ibertsson, Tina
    Lunds Universitet.
    Lyxell, Björn
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Sahlén, Birgitta
    Lunds Universitet.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Cognitive Development in Children With Cochlear Implants (CI)2006Conference paper (Other academic)
  • 258.
    Wass, Malin
    et al.
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Ibertsson, Tina
    Lunds Universitet.
    Lyxell, Björn
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Sahlén, Birgitta
    Lunds Universitet.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Phonological and cognitive development in children with cochlear implants: Speed of performance and level of accuracy as indicators of development2006Conference paper (Other academic)
  • 259.
    Wass, Malin
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Cognition, Development and Disability. Linköping University, Faculty of Arts and Sciences.
    Lyxell, Björn
    Linköping University, Department of Behavioural Sciences and Learning, Cognition, Development and Disability. Linköping University, Faculty of Arts and Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Sahlé, Birgitta
    Deparment of Logopedics, Lund University, Sweden.
    Asker-Árnason, Lena
    Deparment of Logopedics, Lund University, Sweden.
    Ibertsson, Tina
    Deparment of Logopedics, Lund University, Sweden.
    Mäki-Torkko, Elina
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences.
    Hällgren, Mattias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Cognitive Skills and Reading Ability in Children with Cochlear Implants2010In: Cochlear Implants International, ISSN 1467-0100, E-ISSN 1754-7628, Vol. 11, no Suppl. 1, p. 395-398Article in journal (Refereed)
    Abstract [en]

    n/a

  • 260.
    Wass, Malin
    et al.
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Lyxell, Björn
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Sahlén, Birgitt
    Department of Logopedics, Phoniatrics and Audiology, Lund University, Sweden.
    Asker-Árnason, Lena
    Department of Logopedics, Phoniatrics and Audiology, Lund University, Sweden.
    Ibertsson, Tina
    Department of Logopedics, Phoniatrics and Audiology, Lund University, Sweden.
    Mäki-Torkko, Elina
    Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Reading Strategies and Cognitive Skills in Children with Cochlear Implants2010In: Acta Neuropsychologica, ISSN 1730-7503, E-ISSN 2084-4298, Vol. 8, no 2, p. 143-180Article in journal (Refereed)
    Abstract [en]

    The present study investigated WM capacity, lexical access, phonological skills and reading ability in 6 children with cochlear implants (CI), attending grades 1-3. For each test measure, the individual performance of the children with CI was compared to a grade-matched comparison group of children with normal hearing. Performance was also studied in relation to demographic factors. The results reveal that the children with CI have specific difficulties in tasks of phonological skills and phonological working memory (WM) where nonwords are used as test stimuli. They do not seem to have problems with phonological processing of words for which they have a well defined phonological representation. They also experienced relatively more difficulties in tasks on lexical access without any contextual info. We suggest that children with CI are particularly efficient in using compensatory strategies in situations where their auditory perception does not provide sufficient information to correctly match the incoming speech signal to a corresponding representation in the long-term phonological storage. The children with CI in this study are skilled readers, both for decoding of words and nonwords and for reading comprehension. They may use both orthographic and phonological reading strategies although most of them seem to be dependent on phonological decoding to some extent.

  • 261.
    Wass, Malin
    et al.
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Lyxell, Björn
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Sahlén, Birgitta
    Lunds universitet.
    Asker-Arnason, Lena
    Lunds universitet.
    Ibertsson, Tina
    Lunds universitet.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Mäki-Torkko, Elina
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Cognitive skills and reading ability in children with CI2009In: The HEAD graduate School Second Summer Workshop: What's new at HEAD?, 2009, p. 25-Conference paper (Other academic)
  • 262.
    Wass, Malin
    et al.
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Lyxell, Björn
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Sahlén, Birgitta
    Department of Logopedics, Phoniatrics and Audiology, Lund University, Sweden.
    Asker-Árnason, Lena
    Department of Logopedics, Phoniatrics and Audiology, Lund University, Sweden.
    Ibertsson, Tina
    Department of Logopedics, Phoniatrics and Audiology, Lund University, Sweden.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology . Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology . Linköping University, Faculty of Health Sciences.
    Mäki-Torkko, Elina
    Linnaeus Centre HEAD, Linköping University, Sweden.
    In search of cognitive correlates of orthographic learning: Is there a relation between orthographic learning and working memory?Manuscript (preprint) (Other academic)
    Abstract [en]

    The present study investigated the relationships between orthographic learning and other aspects of reading (phonological and orthographic decoding and comprehension) in Swedish children (age 7–9yrs). Cognitive correlates of orthographic learning were also studied, as well as the cognitive predictors of decoding skill and reading comprehension. The results indicated that orthographic learning was related to all the other aspects of reading. Orthographic learning and decoding skills were both related to phonological and visuospatial working memory. Reading comprehension was associated with phonological- and general working memory. The findings are discussed with reference to the component model of working memory.

  • 263.
    Wass, Malin
    et al.
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Lyxell, Björn
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Sahlén, Birgitta
    Lunds universitet.
    Asker-Árnason, Lena
    Lunds universitet.
    Ibertsson, Tina
    Lunds universitet.
    Mäki-Torkko, Elina
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Cognitive Skills and Reading Ability in Children with CI2009Conference paper (Other academic)
  • 264.
    Wass, Malin
    et al.
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Lyxell, Björn
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    Sahlén, Birgitta
    Lunds universitet.
    Asker-Árnason, Lena
    Lunds universitet.
    Ibertsson, Tina
    Lunds universitet.
    Mäki-Torkko, Elina
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Hällgren, Mathias
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Kognitiv utveckling hos barn med cochleaimplantat (CI)2009Conference paper (Other academic)
  • 265.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology, University Hospital, Linköping, Sweden.
    Arlinger, Stig
    Linköping University. Audiology, University Hospital, Linköping, Sweden.
    Edling, Christer
    Östergötlands Läns Landsting. Occupational Medicine, University Hospital, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology, University Hospital, Linköping, Sweden.
    Bergholtz, Lars
    Östergötlands Läns Landsting. Audiology, University Hospital, Linköping, Sweden.
    Audiological and vestibulo-oculomotor findings in workers exposed to solvents and jet fuel1987In: Scandinavian Audiology, ISSN 0105-0397, E-ISSN 1940-2872, Vol. 16, no 2, p. 75-81Article in journal (Refereed)
    Abstract [en]

    Three groups of subjects with long-term (5-41 years) occupational exposure to industrial solvents have been evaluated with extensive audiological and vestibular test batteries. Group A comprised 16 subjects with a confirmed diagnosis of psycho-organic syndrome (POS), while group B consisted of 7 subjects with suspected POS. Both groups had been exposed to mixtures of aliphatic and aromatic solvents. Eight subjects with long-term exposure to jet fuel constituted group C. In the audiological test battery, discrimination of interrupted speech and evoked cortical potentials in response to frequency glides were the tests that yielded significantly abnormal results. In the vestibular test battery, considerable pathology was seen in electronystagmography, and in addition, visual suppression test and saccade test indicated CNS disturbance. In general, when a test yielded pathological results, the incidence of pathology was highest in group A and lowest in group C.

  • 266.
    Ödkvist, Lars
    et al.
    Linköping University.
    Bergholtz, Lars
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Eriksson, Birgitta
    Linköping University.
    Edling, Christer
    Solvent induced central nervous system disturbances appearing in hearing and vestibulo-oculomotor tests1985In: Clinical Ecology, ISSN 0735-9306, Vol. 3, no 3, p. 149-153Article in journal (Refereed)
  • 267.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Fredrickson, John
    University of Toronto, Canada.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Projection of the vestibular nerve to the SI arm field in the cerebral cortex of the cat1975In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 79, no 1-2, p. 88-95Article in journal (Refereed)
    Abstract [en]

    Evoked cortical focal potentials from electrical vestibular nerve stimulation were recorded in the Pcd-area in cats anaesthetized with Chloralose or Nembutal. For comparison, additional cortical projections were located for n. rad. superficialis and group Ia muscle afferents from n. rad. prof., n. fibularis prof., n. femuralis ramus muscularis and the motor nerve to the trapezoid muscle. Surface positive potentials, which reversed to negativity in middle cortical layers, were for vestibular nerve stimulation recorded in the S I forelimb field in a small area close to Pcd in the posterior medial part of the deep radial nerve projection field. The location of this field is compared with the vestibulo-cortical projections described earlier for rodents, squirrel monkey, and rhesus monkey. The histology shows that the field was within the cytoarchitectonic 3a area.

  • 268.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Gripmark, M.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Östergötlands Läns Landsting.
    The subjective horizontal in eccentric rotation influenced by peripheral vestibular lesion1996In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 116, no 2, p. 181-184Article in journal (Refereed)
    Abstract [en]

    Peripheral vestibular equilibrium disorders may originate in various parts of the labyrinth or the vestibular nerve. Traditionally, the function of the lateral semicircular canals has been assessed with caloric irrigation, and sometimes falsely been interpreted as a vestibular nerve lesion. the vertical semicircular canals are not easily assessed. Caloric testing with the head in different positions is not very helpful, but the canals may pairwise be tested using specific rotational techniques. Often the otolithic organs, capable of detecting linear acceleration forces, are forgotten as a source of vertigo and dizziness. We have implemented horizontal rotatory testing with the subject seated eccentrically facing the direction of rotation as a means of assessing otolithic function. the subject experiences a lateral tilt and is instructed in darkness to put a short light bar in the position he thinks a water surface would have, which is identical to his perceived tilt. in 39 normal subjects, a theoretical tilt of 24° was estimated as approximately 19.5°, and the standard deviation was 6°. A side difference index was proposed to be normal if below 25%. the preliminary findings in a few patients with known labyrinthine lesions are presented. We propose that otolithic as well as lateral semicircular canal functions are useful to monitor in patients with suspected peripheral equilibrium disorders.

  • 269.
    Ödkvist, Lars
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Andersson, Hans
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    The visual suppression test1983In: Proc NES 1983, 1983Conference paper (Other academic)
  • 270.
    Ödkvist, Lars
    et al.
    Linköping University.
    Jerlvall, T.
    Andersson, Hans
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    A computerized saccade test - clinical value1983In: Proc NES 1983, 1983, p. 202-208Conference paper (Other academic)
  • 271.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Hydén, Dag
    Linköping University.
    Rotatory tests1993In: NES 1993, 1993Conference paper (Other academic)
  • 272.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    Aschan, Gunnar
    Linköping University.
    Tham, Richard
    Linköping University.
    Influence of industrial solvents on the balance system1977In: International symposium on the control of air pollution in the working environment, 1977, 1977, p. 80-87Conference paper (Other academic)
  • 273.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Linköping University. Östergötlands Läns Landsting.
    Eccentric rotation as a means to assess otolith function: normal subjects and findings in unilateral Menieres Disease1996Conference paper (Other academic)
  • 274.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Liedgren, Christer
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Fredrickson, John
    University of Toronto, Canada.
    Tham, Richard
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Vestibular and oculomotor disturbances caused by industrial solvents1980In: Journal of Otolaryngology, ISSN 0381-6605, Vol. 9, no 1, p. 53-59Article in journal (Refereed)
    Abstract [en]

    Hydrocarbon solvents, xylene, styrene, methylchloroform, and trichlorethylene, given intravenously to rabbits produce a positional nystagmus. Due to their additional influence on rotatory nystagmus, one may conclude that their mode of action takes place in the central nervous system. Optokinetic (OKN) responses in rabbits, cats, and humans were also influenced by styrene. OKN responses have not yet been tested for the other solvents. A comparison is made with the effects of alpha-chloralose and the GABA-antagonists bicuculline and picrotoxin which produced similar disturbances. The GABA agonist, baclofen, prevents positional induced styrene nystagmus. It seems likely therefore that the solvents may act by blocking the cerebellar inhibition of vestibulo-oculomotor reflexes. Solvents given simultaneously in some combinations are either

  • 275.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköping University.
    Disturbancies of the oculomotor system caused byhydrocarbon solvents1981In: Functional basis of Ocular Motility Disorders, 1981, 1981, p. 535-536Conference paper (Other academic)
  • 276.
    Ödkvist, Lars
    et al.
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Tham, Richard
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Aschan, Gunnar
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    On the mechanisms of vestibular disturbancies caused by industrial solvents1979In: Advances in Oto-Rhino-Laryngology, ISSN 0065-3071, E-ISSN 1662-2847, Vol. 25, p. 167-172Article in journal (Refereed)
    Abstract [en]

    The industrial solvents xylene, styrene, trichloroethylene and methylchloroform administered to rabbits caused a positional nystagmus and disturbances in the nystagmus response to rotatory acceleration. The positional nystagmus had a beat direction the opposite to positional alcohol nystagmus, which was in similar experiments elicited by methanol, ethanol and propanol. The three alcohols needed a ten times higher blood concentration to cause a nystagmus than the solvents did.

  • 277.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Vestibular oculomotor dysfunction caused by solvents1982In: Nordic symposium on data processing of eye movements 1982, 1982Conference paper (Other academic)
  • 278.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Vestibulo-oculomotor disturbances caused by industrial solvents1983In: Otolaryngology - Head and Neck Surgery, ISSN 0194-5998, Vol. 91, no 5, p. 537-539Article in journal (Refereed)
    Abstract [en]

    Animal experiments show that intoxication with hydrocarbon solvents influences the vestibulo-oculomotor reflex arc and indicate that the solvents block the inhibition of the vestibulo-oculomotor reflex presumably exerted by the cerebellum. The blood concentrations necessary to elicit oculomotor disturbances in animals were smaller than those that disturbed the vestibular function. Accordingly, in human experiments styrene and toluene exposure did not elicit any positional nystagmus but caused an increased saccade speed and a diminished visual suppression of vestibular nystagmus. Some cerebellar clinical pathologic process in patients who suffer from a psycho-organic syndrome caused by solvents leads us to believe that the cerebellum might be the most vulnerable part of the brain. Some patients had a positional nystagmus, but the most prominent pathologic signs were elicited by the visual suppression test. Our findings compare well with the increased saccade speed and diminished visual suppression in patients with cerebellar tumors and infarctions

  • 279.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Aschan, Gunnar
    Linköping University.
    Positional nystagmus elicited by industrial solvents1978In: Vestibular mechanisms in health and disease, 1978 / [ed] Hood JD, Academic Press, 1978, p. 18-27Conference paper (Other academic)
  • 280.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden .
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Tham, Richard
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Åhlfeldt, H.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Andersson, Björn
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Eriksson, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Liedgren, Christer
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Vestibulo-oculomotor disturbances in humans exposed to styrene1982In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 94, no 1-6, p. 487-493Article in journal (Refereed)
    Abstract [en]

    Several reports indicate that disturbances of the vestibulo-oculomotor ability are a manifestation of the toxic action on the central nervous system exerted by some industrial solvents. The aim of the present investigation was to examine the vestibulo-oculomotor system during exposure to styrene, which is extensively used in the production of plastics. Healthy volunteers were exposed to styrene for one hour. Rotatory and optokinetic nystagmus, visual suppression as well as speed, latency and accuracy of saccades were tested before, during, and one hour after the exposure. The pulmonary uptake and the blood level of the solvent were continuously analysed by gas chromatography. The styrene blood concentration was equivalent to that which may well be reached after several hours of hard work in an industrial environment with a concentration of styrene within permitted limits. No spontaneous nystagmus appeared. The rotatory and optokinetic nystagmus was not influenced by styrene. However, the speed of the saccade was significantly enhanced. The visual suppression was disturbed, shown by an increased gain after styrene exposure. The experiments thus indicate that styrene given to healthy test persons induced disturbances, thus consistent with the theory that some organic solvents block the cerebellar inhibition of the vestibulo-oculomotor system.

  • 281.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Ledin, Torbjörn
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Gripmark, M.
    Noaksson, Lisbeth
    Östergötlands Läns Landsting.
    Olsson, S.
    Östergötlands Läns Landsting.
    Otolithic tests in Menière’s disease1995In: Ménièr's Disease, 1995 / [ed] Vesterhauge S, Katholm M, Mikines P, 1995, p. 259-265Conference paper (Other academic)
  • 282.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Östergötlands Läns Landsting.
    Jerlvall, L.
    Östergötlands Läns Landsting.
    Vestibular and somatosensory inflow to the vestibular projection area in the post cruciate dimple region of the gat cerebral cortex1975In: Experimental Brain Research, ISSN 0014-4819, E-ISSN 1432-1106, Vol. 22, no 2, p. 185-196Article in journal (Refereed)
    Abstract [en]

    In anesthetized cats 251 cells within the cortical vestibular projection area, adjacent to the post-cruciate dimple, were analyzed as to their input characteristics employing extracellular recording techniques. The post cruciate dimple vestibular field, which is located in area 3a, has a high degree of convergence between vestibular and peripheral somatosensory input. The latter is not restricted to muscle afferents but includes cutaneous modalities. The functional significance of this vestibular cortical projection field is discussed.

  • 283.
    Ödkvist, Lars
    et al.
    Linköping University.
    Möller, C.
    Linköping University.
    Thell, Jan
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    Gentamycin-treated Meniere's disease evaluated by rotatory tests1985In: Myers E, editor.; Elsevier SiencePublishers B.V.; 1985 / [ed] Myers E,, 1985, p. 43-44Conference paper (Other academic)
  • 284.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Vestibulr Compensation Measured by the Broad-Frequency Band Rotatory Test1987In: The Vestibular system: Neurophysiologic and clinical research / [ed] Malcolm D. Graham, John L. Kemink, New York: Raven Press , 1987, p. 287-291Conference paper (Refereed)
  • 285.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Edling, Christer
    Bergholtz, Lars
    Östergötlands Läns Landsting.
    Tidig diagnostik vid lösningsmedelsskada1982In: Sv Otolaryngol förening 1982;2, 1982, p. 2-Conference paper (Other academic)
  • 286.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Aschan, Gunnar
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Hur inverkar industriella lösningsmedel på balansapparaten1978In: Läkaresällskapets riksstämma 1978, 1978Conference paper (Other academic)
  • 287.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Åhlfeldt, H.
    Linköping University.
    Andersson, Björn
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Vestibulo-oculomotor findings during styrene exposure1981In: World Congress of Otolaryngol 1981, 1981Conference paper (Other academic)
  • 288.
    Ödkvist, Lars
    et al.
    Linköping University.
    Thell, Jan
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Vascular cause for vertigo1986In: Claussen C-F, Kirtane MV, editors. Vertigo, nausea,tinnitus and hearing loss in cardiovasculr disease.: Elsevier SciencePublishers B.V.; 1986, 1986, p. 61-68Conference paper (Other academic)
  • 289.
    Ödkvist, Lars
    et al.
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    Thell, Jan
    Östergötlands Läns Landsting. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    A comparison between smooth pursuit and visual suppression1988In: Advances in Oto-Rhino-Laryngology, ISSN 0065-3071, E-ISSN 1662-2847, Vol. 41, p. 109-115Article in journal (Refereed)
  • 290.
    Ödkvist, Lars
    et al.
    Linköping University.
    Åstrand, I.
    Arbetsmiljöinstitutet.
    Larsby, Birgitta
    Linköping University.
    Käll, K.
    Arbetsmiljöinstitutet.
    Ger lösningsmedel störningar i vestibulo-oculomotorsystemet ?1980In: Arbete och Hälsa, ISSN 0346-7821, Vol. 2, no 1Article in journal (Other academic)
  • 291.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Technology in rotatory testing. 18th Bárány Society Meeting in Uppsala, June 6-8,1994.1994In: 18th Bárány Society Meeting in Uppsala, June 6-8,1994., 1994Conference paper (Other academic)
  • 292.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Influence of industrial solvents on the vestibular system.1978In: World congress on otolaryngology 1978, Miami Beach, 1978, p. 275-Conference paper (Other academic)
  • 293.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Nackafferenter and vestibularis. Sv Otolaryngol förening 1995;1:45-46.1995In: Sv Otolaryngol förening 1995, 1995, p. 45-46Conference paper (Other academic)
  • 294.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Integration mellan proprioception och N.Vestibularis i CNS.1974In: Läkaresällskapets riksstämma 1974., 1974Conference paper (Other academic)
  • 295.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Thell, Jan
    Östergötlands Läns Landsting.
    Bengtsson, Ann
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Vertigo in fibromyalgi1986In: In: Claussen C-F, Kirtane MV, editors. Vertigo,nausea, tinnitus and hearing loss in cardiovascular diseases.: Elsevier SciencePublishers B.V. 1986 / [ed] Claussen C-F, Kirtane MV, 1986, p. 429-433Conference paper (Other academic)
  • 296.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Thell, Jan
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    A Comparison between Smooth Pursuit and Visual Suppression1988In: In Adv. Oto-Rhino-Laryng. Vol 41, 109-115. / [ed] Pirodda E, Pompeiano O., 1988, p. 109-115Conference paper (Refereed)
3456 251 - 296 of 296
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