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  • 25901.
    Öberg, Tommy
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    Oberg, U.
    Öberg, U., Department of Physiotherapy, County Hospital, Eksjö, Sweden.
    Sviden, G.
    Svidén, G., Department of Rehabilition, Jönköping University, PO Box 1026, SE-551 11 Jönköping, Sweden.
    Persson, A.N.
    Department of Occupational Therapy, County Hospital, Eksjö, Sweden.
    Functional capacity after hip arthroplasty: A comparison between evaluation with three standard instruments and a personal interview2005In: Scandinavian Journal of Occupational Therapy, ISSN 1103-8128, E-ISSN 1651-2014, Vol. 12, no 1, p. 18-28Article in journal (Refereed)
    Abstract [en]

    The aim of the present study was to compare the information obtained from three standard instruments used in physiotherapy and occupational therapy and with information acquired from an unstructured interview. Ten patients with osteoarthritis of the hip were consecutively picked from the waiting list at an orthopedic clinic. All were examined before and six months after arthroplasty. The study layout is a mixture of quantitative and qualitative evaluation. The three instruments used were SF-36 (self-reported health-related quality of life), FAS (an instrument for evaluation of lower extremity dysfunction), and the COPM (for evaluation of self-experienced activity level). All patients were also interviewed in a free, unstructured interview, and data were analyzed with a phenomenological approach. All methods could describe function and activity status of the patients very well, and they were also responsive to postoperative improvement. Together the three instruments gave such good information that almost no extra information was obtained through the interviews. On the other hand, the interviews served as powerful validation of the three instruments. The information in the three separate instruments is qualitatively different, and one instrument cannot replace another. They cannot be replaced by the interview either, because the instruments provide the therapist with specific and structured information that is important for further treatment planning and follow-up. © 2005 Taylor & Francis.

  • 25902.
    Öberg, Ulrika
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
    Functional assessment system of lower-extremity dysfunction1996Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The Functional Assessment System (FAS) is a new instrument for evaluation of lower-extremity dysfunction. It consists of 20 variables, representing major lower--extremity functions related to daily life activities. The variables are divided into five groups: hip impairment, knee impairment, physical disability, social disability, and paiu variables. The grouping agrees fairly well with the WHO classification of impairment, disabilities and handicaps. Every variable is given a disability score on a five-point scale. The scores are plotted into a diagram, giving an individual functional profile. The profile can be used to document present functional status, for goal-setting, and for follow-up after treatment. It can also be used to design individual training programs.

    The aim of this thesis was:

    • to present the new Functional Assessment System (FAS)

    • to examine the metric properties of the FAS, and

    • to apply the FAS in some clinical situations.

    The FAS was applied on a series of patients with osteoarthritis of the hip or knee. Content validity was tested with factor analysis. The obtained factor structure agreed very well with the preliminary grouping of the variables. Concurrent validity was tested by comparison with measurements from the AIMS (Arthritis Impact Measurement Scales), the Rosser-Kind index (for evaluation of quality of life), and a radiographic scale for grading of osteoarthritis. There was a good agreement between the measurements of the FAS and the physical variables of the AIMS. There was also a good agreement between the FAS and the results obtained by the Rosser-Kind index. There was a low agreement between the FAS and the psychosocial variables of the AIMS. There was also a low correlation between the radiographic grading of osteoarthritis and the functional status recorded with the FAS. Inter-tester reliability was evaluated as correlation between the measurements performed by two independent physiotherapists. There was an almost perfect agreement between the two testers. The FAS was also tested for discriminatory power. It showed a good ability to differentiate between healthy subjects and patients with osteoarthritis. It also had a good power to discriminate between different degrees of the disease. The disability group of variables had better discriminstory power than the impairment group of variables. Most variables had a high specificity, whereas high sensitivity was mainly found in the disability group of variables and pain. The FAS was used to measure outcome after arthroplasty. A baseline functional status was recorded before surgery, and a goal profile was made. Six months later there was a striking improvement, especially in the disability variables and pain, and there was a high degree of goal achievement of most patients in most variables. Patients admitted for arthroplasty were examined for age-related diffirences in founctional status, Despite the fact that age was not included in the criteria for operation, old people had significantly lower functional status. This finding may indicate a hidden age criterion for referral of patients for arthroplasty. The age-related changes were mainly found in the disability group of variables. These findings may speak in favor of early surgery of patients with osteoarthritis.

    To summarize: The FAS had very good metric properties, such as validity, intertester reliability, discriminatory power, sensitivity and specificity. It was also a useful instrument in a clinical setting to record functional status, to set an individual treatment goal, and as an instrument for follow-up and outcome measurements. It was also sensitive in detecting age-related differences in patients admitted for arthroplasty. It can be used to communicate functional status to other health professionals, and to establish realistic goals for the patient.

  • 25903. Öberg, Ulrika
    et al.
    Öberg, Tommy
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    Functional outcome after high tibial osteotomy: A study using individual goal achievement as the primary outcome variable2000In: Journal of rehabilitation research and development, ISSN 0748-7711, E-ISSN 1938-1352, Vol. 37, no 5, p. 501-510Article in journal (Refereed)
    Abstract [en]

    Functional outcome after high tibial osteotomy (HTO) was evaluated with respect to both improvement and goal achievement. Fifty-seven subjects, 32 men and 25 women, with a mean age of 55 years were examined with the Functional Assessment System (FAS) 6 and 12 months after surgery. The FAS is an evaluation system, specifically designed to monitor lower extremity dysfunction. It shows a profile with preoperative status, individual goal, and postoperative status. Statistically significant improvement was seen in 6/20 variables after 6 months, and in 10/20 variables after 12 months. When goal achievement was examined, the results were not as impressive. The treatment goal was not reached on the group level for almost all variables. On the individual level, only 20\N40% of the patients achieved the goal as a result of surgery in most variables. Exceptions were pain and leisure time/hobbies, where there was a high degree of goal achievement. It is possible that postoperative training was inadequate. The authors recommend a new randomized study, where patients who receive specific individual training related to the individual goal and functional profile are compared with a control group.

  • 25904.
    Öberg, Åke
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Bio-Optics in Medicine2003In: Medical & Biological Engineering & Computing, ISSN 0140-0118, Vol. 41, p. 241-241Article in journal (Other academic)
    Abstract [en]

    Guest editor

  • 25905.
    Öberg, Åke
    Linköping University, Department of Biomedical Engineering, Physiological Measurements. Linköping University, The Institute of Technology.
    Medicinsk teknik i Japan1973Report (Other (popular science, discussion, etc.))
  • 25906.
    Öberg, Åke
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Optical sensors for heart- and respiratory rate measurements. Academic prototypes and clinical evaluation1996In: International Conference IEEE Engineering in Medicine and Biology Society,1996, IEEE , 1996Conference paper (Refereed)
  • 25907.
    Öberg, Åke
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Optical sensors in medical care2004In: Sensors in Medicine and Health Care / [ed] Åke Öberg; Tatsuo Togawa and Francis A Spelman, Weinheim, Germany: WileyVCH Verlag , 2004, p. 15-44Chapter in book (Other academic)
    Abstract [en]

    Due to remarkable developments in the field of sensors along with miniaturization, sophisticated microsensors are part of many aspects of 21st century medicine and health care. Turning sensory inputs of all kinds into defined electrical signals that can be  interpreted and acted upon by both stationary and portable medicne  equipment as well as implants, sensors find many applications monitoring blood pressure, heart rates, glucose levels and many other parameters by which human health can be evaluated.         

    They also serve as key components in modern imaging equipment as well as operating equipment for minimally invasive surgery,catheters and other applications.         

    Taken as a whole, Sensors Applications covers all major fields  of application for commercial sensors, as well as their  manufacturing techniques and major types. Strong emphasis is placedon microsensors, microsystems and integrated electronic sensor  packages rather than bulk equipment. Each of the individual volumes is tailored to the needs and queries of readers from the relevant branches of industry and research.

  • 25908.
    Öberg, Åke
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Optical sensors in Medical Care2004In: Sensors Update: sensor technology, applications, markets]. Vol. 13 / [ed] H. Baltes, G.K. Fedder, J.G. Korvink, Weinheim, Germany: WileyVCH Verlag , 2004, p. 201-232Chapter in book (Other academic)
  • 25909.
    Öberg, Åke
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Tissue motion - a disturbance in the Laser-Doppler blood flow signal?1999In: Technology and Health Care, ISSN 0928-7329, Vol. 7, p. 185-192Article in journal (Refereed)
  • 25910.
    Öberg, Åke
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Salerud, Göran
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation.
    Microprobes for blood flow measurements in tissue and small vessels1988In: SPIE Vol 94 Microsensors and Catheter-Based Imaging and Technology,1988, 1988, p. 35-Conference paper (Refereed)
  • 25911.
    Öberg, Åke
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Spelman, Francis A.
    Dept. of Bioengineering University of Washington.
    Togawa, Tatsuo
    School of Human Sciences Waseda University.
    Introduction2004In: Sensors in Medicine and Health Care / [ed] P. Å. Öberg, Tatsuo Togawa, Francis A. Spelman, Weinheim, Germany: WileyVCH Verlag , 2004, p. -420Chapter in book (Other academic)
    Abstract [en]

    Due to remarkable developments in the field of sensors along with miniaturization, sophisticated microsensors are part of many aspects of 21st century medicine and health care. Turning sensory inputs of all kinds into defined electrical signals that can be  interpreted and acted upon by both stationary and portable medicne  equipment as well as implants, sensors find many applications monitoring blood pressure, heart rates, glucose levels and many other parameters by which human health can be evaluated.        

    They also serve as key components in modern imaging equipment as well as operating equipment for minimally invasive surgery,catheters and other applications.        

    Taken as a whole, Sensors Applications covers all major fields  of application for commercial sensors, as well as their  manufacturing techniques and major types. Strong emphasis is placedon microsensors, microsystems and integrated electronic sensor  packages rather than bulk equipment. Each of the individual volumes is tailored to the needs and queries of readers from the relevant branches of industry and research.

  • 25912.
    Öberg, Åke
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Spelman, Francis A.
    Dept. of Bioengineering University of Washington, USA.
    Togawa, Tatsuo
    School of Human Sciences Waseda University.
    Sensors in Medicine and Health Care2004Book (Other academic)
    Abstract [en]

    Due to remarkable developments in the field of sensors along with miniaturization, sophisticated microsensors are part of many aspects of 21st century medicine and health care. Turning sensory inputs of all kinds into defined electrical signals that can be  interpreted and acted upon by both stationary and portable medicne  equipment as well as implants, sensors find many applications monitoring blood pressure, heart rates, glucose levels and many other parameters by which human health can be evaluated.       

    They also serve as key components in modern imaging equipment as well as operating equipment for minimally invasive surgery,catheters and other applications.       

    Taken as a whole, Sensors Applications covers all major fields  of application for commercial sensors, as well as their  manufacturing techniques and major types. Strong emphasis is placedon microsensors, microsystems and integrated electronic sensor  packages rather than bulk equipment. Each of the individual volumes is tailored to the needs and queries of readers from the relevant branches of industry and research.

  • 25913.
    Öberg, Åke
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Sundqvist, Tommy
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
    Johansson, Anders
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Assessment of cartilage thickness utilising reflectance spectroscopy2004In: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 42, no 1Article in journal (Refereed)
    Abstract [en]

    A new principle for cartilage layer thickness assessments in joints is presented. It is based on the differences between the absorption spectra of cartilage and subchondral bone (containing blood). High-resolution ultrasound measurements of cartilage thickness were compared with reflection spectroscopy data from the same area of bovine hip joint condyles. A simple mathematical model allowed calculation of thickness and comparison with ultrasound data. The cartilage thickness was changed by being ground in short episodes. For thicker cartilage layers, a high degree of reflection in the 400-600nm wavelength interval was seen. For thinner cartilage layers, the characteristics of the spectra of blood and bone dominated those of cartilage. The mean (±SD) thickness of intact cartilage was 1.21± 0.30 mm (n = 30). In an exponential regression model, spectroscopic estimation of cartilage thickness showed a correlation coefficient of r= 0.69 (n = 182). For thinner cartilage layers (d<0.5mm), the mean model error was 0.19±0.17mm. Results from a bi-layer Monte Carlo simulation supported the assumption of an exponential relationship between spectroscopy data and reference ultrasound data. The conclusion is that optical reflection spectroscopy can be used for cartilage layer thickness assessment.

  • 25914.
    Öberg, Åke
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Sundqvist, Tommy
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
    Johansson, Anders
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Sundberg, Mikael
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation.
    Characterisation of the cartilage/bone interface utilising reflectance spectroscopy2001In: 23rd Annual International Conference IEEE EMBS,2001, IEEE , 2001, Vol. 3, p. 3002-3004Conference paper (Refereed)
    Abstract [en]

    Optical reflection spectra of the cartilage/bone interface from hip joints of cows were studied. When comparing to ultrasonic measurement, it was found that cartilage thickness could be extracted using optical reflectance spectroscopy. For thicker cartilage layers, a high reflection for the wavelengths 400-600 nm was seen, and for thinner cartilage layers, the characteristic spectra of blood and bone dominated. The optical reflectance spectra may be used to characterise cartilage, and specifically cartilage thickness, in connection with in situ diagnosis or autologous chondrocyte implantation (ACI).

  • 25915.
    Öberg, Åke
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Tamura, T.
    Lindberg, Lars-Göran
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Salerud, Göran
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation.
    A comparison between laser Doppler flowmetry and photoplethysmography1988In: Betch. AMH CCCP,1988, 1988, p. 82-Conference paper (Refereed)
  • 25916.
    Öcal, Fatos
    et al.
    Linköping University, Department of Social and Welfare Studies, Division of Nursing Science.
    Säfström, Moa
    Linköping University, Department of Social and Welfare Studies, Division of Nursing Science.
    Livsstilsförändringar i efterförloppet av akut kranskärlssjukdom: En litteraturstudie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Bakgrund: Efter akut kranskärlssjukdom är det viktigt att förändra sin livsstil då det har stor betydelse för framtidsutsikten för dessa patienter. Trots detta så förändrar inte alla patienter sina livsstilsvanor, eller klarar av att bibehålla de nyligen förändrade vanorna.  

    Syfte: Syftet var att studera vad som påverkar genomförandet av livsstilsförändringar hos personer i efterförloppet av akut kranskärlssjukdom.  

    Metod: Litteraturstudie med ett systematiskt tillvägagångssätt. Datainsamling genomfördes i databaserna CINAHL, PsycINFO, PubMed, Swemed+ och UniSearch. Efter datainsamling och kvalitetsgranskning inkluderades 15 artiklar varav nio kvalitativa artiklar och sex kvantitativa artiklar. För bearbetning av data utfördes en analys där fyra huvudkategorier identifierades.  

    Resultat: De fyra huvudkategorierna som identifierades var: Den enskilde individen, Kunskap, Inre faktorer och Yttre faktorer. Dessa områden kunde både främja och/eller hämma genomförandet av livsstilsförändring i efterförloppet av akut kranskärlssjukdom.   

    Konklusion: Sjuksköterskan bör vara medveten om den multifaktoriella process som livsstilsförändring innebär för patienten. Patientens behov kan tillgodoses genom tydlig information om sjukdomen men även andra aspekter såsom livsstilsförändring och hantering av förändring. Patienten behöver stöd från sjukvården, likasinnade och närstående för att kunna förändra sin livsstil.

  • 25917.
    Ödkvist, L
    Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Pressure treatment versus gentamicin for MΘniΦre's disease2001In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 121, no 2, p. 266-268Article in journal (Refereed)
    Abstract [en]

    MΘniΦre's disease may be treated in different ways. After obtaining a case history and performing auditory and vestibular tests the diagnosis should be obvious. In terms of treatment, the first steps are to provide the patient with information, institute a low-salt diet and regulate internal medical disorders. The next step is pharmacological treatment using diuretics, betahistine and other drugs. Local pulsated pressure treatment in the ear canal has been used in a placebo-controlled study and showed significant improvement, primarily of vertigo, but also in terms of tinnitus and hearing. Hence, this form of treatment can be used in some phases of the disease. In more severe cases gentamicin treatment has proved successful, in the present study, vertigo was cured in all but 3 of 35 patients. On average, no extra hearing loss was caused, however, one ear became deaf, some ears showed improvement and some ears showed a certain degree of hearing loss. In cases of escalation of MΘniΦre's disease, pressure treatment should be used initially, followed by gentamicin. These two methods of treatment are not in competition as they are used to treat different stages of the disease.

  • 25918.
    Ödkvist, Lars
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Arlinger, Stig
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Technical Audiology. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Billermark, Erica
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, RC - Rekonstruktionscentrum, ÖNH - Öron- Näsa- Halskliniken.
    Densert, B
    Lindholm, S
    Wallqvist, J
    Effects of middle ear pressure changes on clinical symptoms in patients with MΘniΦre's disease - A clinical multicentre placebo-controlled study2000In: Acta oto-laryngologica. Supplementum, ISSN 0365-5237, E-ISSN 1651-2464, no 543, p. 99-101Article in journal (Refereed)
    Abstract [en]

    Different medical and surgical methods have been tried in attempting to reduce endolymphatic pressure in MΘniΦre's disease. Pressure treatment has a role on the treatment staircase, after pharmacological treatment and before destructive methods. Pressure chamber treatment has shown that some patients respond well to the treatment with diminishing inner ear symptoms and also some hearing improvement. Earlier studies have shown that electrocochlear measurements improve after local pressure treatment in the ear. The present study was a prospective randomized placebo controlled, multicentre clinical trial. 56 patients with active MΘniΦre's disease, age 20-65 years, with a hearing loss of 20-65 dB PTA participated. A total of 31 patients completed 2 weeks use with an active apparatus (Meniett) and 25 patients completed the 2 weeks with the placebo gadget. Both machines were produced by Pascal Medical, Halmstad, Sweden. Two weeks before the start of treatment a grommet was placed in the tympanic membrane. A significant improvement concerning frequency and intensity of vertigo, dizziness, aural pressure and tinnitus was reported by the active group on the visual analogue scales (VAS) questionnaire. In the placebo group no change was the most common finding, followed by worsening of the symptoms and a few improvements. The function in professional and family life improved during active treatment and did not during placebo treatment. Pure-tone audiometry did not improve after placebo treatment, but improved at the frequencies 500 Hz and 1,000 Hz after active treatment. The study showed an improvement in the inner ear symptoms after Meniett treatment. The mechanism may be explained by the influence on the round window membrane pressure receptors or an endolymphatic flow out through the pressure release points, such as the endolymphatic duct and sac, thus activating the longitudinal flow. Other mechanisms are also possible.

  • 25919.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology, University Hospital, Linköping, Sweden.
    Arlinger, Stig
    Linköping University. Audiology, University Hospital, Linköping, Sweden.
    Edling, Christer
    Östergötlands Läns Landsting. Occupational Medicine, University Hospital, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology, University Hospital, Linköping, Sweden.
    Bergholtz, Lars
    Östergötlands Läns Landsting. Audiology, University Hospital, Linköping, Sweden.
    Audiological and vestibulo-oculomotor findings in workers exposed to solvents and jet fuel1987In: Scandinavian Audiology, ISSN 0105-0397, E-ISSN 1940-2872, Vol. 16, no 2, p. 75-81Article in journal (Refereed)
    Abstract [en]

    Three groups of subjects with long-term (5-41 years) occupational exposure to industrial solvents have been evaluated with extensive audiological and vestibular test batteries. Group A comprised 16 subjects with a confirmed diagnosis of psycho-organic syndrome (POS), while group B consisted of 7 subjects with suspected POS. Both groups had been exposed to mixtures of aliphatic and aromatic solvents. Eight subjects with long-term exposure to jet fuel constituted group C. In the audiological test battery, discrimination of interrupted speech and evoked cortical potentials in response to frequency glides were the tests that yielded significantly abnormal results. In the vestibular test battery, considerable pathology was seen in electronystagmography, and in addition, visual suppression test and saccade test indicated CNS disturbance. In general, when a test yielded pathological results, the incidence of pathology was highest in group A and lowest in group C.

  • 25920.
    Ödkvist, Lars
    et al.
    Linköping University.
    Bergholtz, Lars
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Eriksson, Birgitta
    Linköping University.
    Edling, Christer
    Solvent induced central nervous system disturbances appearing in hearing and vestibulo-oculomotor tests1985In: Clinical Ecology, ISSN 0735-9306, Vol. 3, no 3, p. 149-153Article in journal (Refereed)
  • 25921.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Fredrickson, John
    University of Toronto, Canada.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linkoping, Sweden.
    Projection of the vestibular nerve to the SI arm field in the cerebral cortex of the cat1975In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 79, no 1-2, p. 88-95Article in journal (Refereed)
    Abstract [en]

    Evoked cortical focal potentials from electrical vestibular nerve stimulation were recorded in the Pcd-area in cats anaesthetized with Chloralose or Nembutal. For comparison, additional cortical projections were located for n. rad. superficialis and group Ia muscle afferents from n. rad. prof., n. fibularis prof., n. femuralis ramus muscularis and the motor nerve to the trapezoid muscle. Surface positive potentials, which reversed to negativity in middle cortical layers, were for vestibular nerve stimulation recorded in the S I forelimb field in a small area close to Pcd in the posterior medial part of the deep radial nerve projection field. The location of this field is compared with the vestibulo-cortical projections described earlier for rodents, squirrel monkey, and rhesus monkey. The histology shows that the field was within the cytoarchitectonic 3a area.

  • 25922.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Gripmark, M.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Östergötlands Läns Landsting.
    The subjective horizontal in eccentric rotation influenced by peripheral vestibular lesion1996In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 116, no 2, p. 181-184Article in journal (Refereed)
    Abstract [en]

    Peripheral vestibular equilibrium disorders may originate in various parts of the labyrinth or the vestibular nerve. Traditionally, the function of the lateral semicircular canals has been assessed with caloric irrigation, and sometimes falsely been interpreted as a vestibular nerve lesion. the vertical semicircular canals are not easily assessed. Caloric testing with the head in different positions is not very helpful, but the canals may pairwise be tested using specific rotational techniques. Often the otolithic organs, capable of detecting linear acceleration forces, are forgotten as a source of vertigo and dizziness. We have implemented horizontal rotatory testing with the subject seated eccentrically facing the direction of rotation as a means of assessing otolithic function. the subject experiences a lateral tilt and is instructed in darkness to put a short light bar in the position he thinks a water surface would have, which is identical to his perceived tilt. in 39 normal subjects, a theoretical tilt of 24° was estimated as approximately 19.5°, and the standard deviation was 6°. A side difference index was proposed to be normal if below 25%. the preliminary findings in a few patients with known labyrinthine lesions are presented. We propose that otolithic as well as lateral semicircular canal functions are useful to monitor in patients with suspected peripheral equilibrium disorders.

  • 25923.
    Ödkvist, Lars
    et al.
    Linköping University.
    Hydén, Dag
    Linköping University.
    Andersson, Hans
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    The visual suppression test1983In: Proc NES 1983, 1983Conference paper (Other academic)
  • 25924.
    Ödkvist, Lars
    et al.
    Linköping University.
    Jerlvall, T.
    Andersson, Hans
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    A computerized saccade test - clinical value1983In: Proc NES 1983, 1983, p. 202-208Conference paper (Other academic)
  • 25925.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Hydén, Dag
    Linköping University.
    Rotatory tests1993In: NES 1993, 1993Conference paper (Other academic)
  • 25926.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    Aschan, Gunnar
    Linköping University.
    Tham, Richard
    Linköping University.
    Influence of industrial solvents on the balance system1977In: International symposium on the control of air pollution in the working environment, 1977, 1977, p. 80-87Conference paper (Other academic)
  • 25927.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Ledin, Torbjörn
    Linköping University. Östergötlands Läns Landsting.
    Eccentric rotation as a means to assess otolith function: normal subjects and findings in unilateral Menieres Disease1996Conference paper (Other academic)
  • 25928.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Liedgren, Christer
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Fredrickson, John
    University of Toronto, Canada.
    Tham, Richard
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, Regional-and University Hospital, Linköping University, Linköping, Sweden.
    Vestibular and oculomotor disturbances caused by industrial solvents1980In: Journal of Otolaryngology, ISSN 0381-6605, Vol. 9, no 1, p. 53-59Article in journal (Refereed)
    Abstract [en]

    Hydrocarbon solvents, xylene, styrene, methylchloroform, and trichlorethylene, given intravenously to rabbits produce a positional nystagmus. Due to their additional influence on rotatory nystagmus, one may conclude that their mode of action takes place in the central nervous system. Optokinetic (OKN) responses in rabbits, cats, and humans were also influenced by styrene. OKN responses have not yet been tested for the other solvents. A comparison is made with the effects of alpha-chloralose and the GABA-antagonists bicuculline and picrotoxin which produced similar disturbances. The GABA agonist, baclofen, prevents positional induced styrene nystagmus. It seems likely therefore that the solvents may act by blocking the cerebellar inhibition of vestibulo-oculomotor reflexes. Solvents given simultaneously in some combinations are either

  • 25929.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Tham, Richard
    Linköping University.
    Disturbancies of the oculomotor system caused byhydrocarbon solvents1981In: Functional basis of Ocular Motility Disorders, 1981, 1981, p. 535-536Conference paper (Other academic)
  • 25930.
    Ödkvist, Lars
    et al.
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Tham, Richard
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden.
    Aschan, Gunnar
    Linköping University. Department of Otolaryngology and Department of Clinical Pharmacology, Regional and University Hospital, Linköping University, Linköping, Sweden .
    On the mechanisms of vestibular disturbancies caused by industrial solvents1979In: Advances in Oto-Rhino-Laryngology, ISSN 0065-3071, E-ISSN 1662-2847, Vol. 25, p. 167-172Article in journal (Refereed)
    Abstract [en]

    The industrial solvents xylene, styrene, trichloroethylene and methylchloroform administered to rabbits caused a positional nystagmus and disturbances in the nystagmus response to rotatory acceleration. The positional nystagmus had a beat direction the opposite to positional alcohol nystagmus, which was in similar experiments elicited by methanol, ethanol and propanol. The three alcohols needed a ten times higher blood concentration to cause a nystagmus than the solvents did.

  • 25931.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Vestibular oculomotor dysfunction caused by solvents1982In: Nordic symposium on data processing of eye movements 1982, 1982Conference paper (Other academic)
  • 25932.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Vestibulo-oculomotor disturbances caused by industrial solvents1983In: Otolaryngology - Head and Neck Surgery, ISSN 0194-5998, Vol. 91, no 5, p. 537-539Article in journal (Refereed)
    Abstract [en]

    Animal experiments show that intoxication with hydrocarbon solvents influences the vestibulo-oculomotor reflex arc and indicate that the solvents block the inhibition of the vestibulo-oculomotor reflex presumably exerted by the cerebellum. The blood concentrations necessary to elicit oculomotor disturbances in animals were smaller than those that disturbed the vestibular function. Accordingly, in human experiments styrene and toluene exposure did not elicit any positional nystagmus but caused an increased saccade speed and a diminished visual suppression of vestibular nystagmus. Some cerebellar clinical pathologic process in patients who suffer from a psycho-organic syndrome caused by solvents leads us to believe that the cerebellum might be the most vulnerable part of the brain. Some patients had a positional nystagmus, but the most prominent pathologic signs were elicited by the visual suppression test. Our findings compare well with the increased saccade speed and diminished visual suppression in patients with cerebellar tumors and infarctions

  • 25933.
    Ödkvist, Lars
    et al.
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Tham, Richard
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Aschan, Gunnar
    Linköping University.
    Positional nystagmus elicited by industrial solvents1978In: Vestibular mechanisms in health and disease, 1978 / [ed] Hood JD, Academic Press, 1978, p. 18-27Conference paper (Other academic)
  • 25934.
    Ödkvist, Lars
    et al.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden .
    Larsby, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Tham, Richard
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Åhlfeldt, H.
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Andersson, Björn
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Eriksson, Birgitta
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Liedgren, Christer
    Linköping University. Departments of Otolaryngology and Clinical Pharmacology, University Hospital, Linköping, Sweden.
    Vestibulo-oculomotor disturbances in humans exposed to styrene1982In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 94, no 1-6, p. 487-493Article in journal (Refereed)
    Abstract [en]

    Several reports indicate that disturbances of the vestibulo-oculomotor ability are a manifestation of the toxic action on the central nervous system exerted by some industrial solvents. The aim of the present investigation was to examine the vestibulo-oculomotor system during exposure to styrene, which is extensively used in the production of plastics. Healthy volunteers were exposed to styrene for one hour. Rotatory and optokinetic nystagmus, visual suppression as well as speed, latency and accuracy of saccades were tested before, during, and one hour after the exposure. The pulmonary uptake and the blood level of the solvent were continuously analysed by gas chromatography. The styrene blood concentration was equivalent to that which may well be reached after several hours of hard work in an industrial environment with a concentration of styrene within permitted limits. No spontaneous nystagmus appeared. The rotatory and optokinetic nystagmus was not influenced by styrene. However, the speed of the saccade was significantly enhanced. The visual suppression was disturbed, shown by an increased gain after styrene exposure. The experiments thus indicate that styrene given to healthy test persons induced disturbances, thus consistent with the theory that some organic solvents block the cerebellar inhibition of the vestibulo-oculomotor system.

  • 25935.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Ledin, Torbjörn
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Gripmark, M.
    Noaksson, Lisbeth
    Östergötlands Läns Landsting.
    Olsson, S.
    Östergötlands Läns Landsting.
    Otolithic tests in Menière’s disease1995In: Ménièr's Disease, 1995 / [ed] Vesterhauge S, Katholm M, Mikines P, 1995, p. 259-265Conference paper (Other academic)
  • 25936.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Östergötlands Läns Landsting.
    Jerlvall, L.
    Östergötlands Läns Landsting.
    Vestibular and somatosensory inflow to the vestibular projection area in the post cruciate dimple region of the gat cerebral cortex1975In: Experimental Brain Research, ISSN 0014-4819, E-ISSN 1432-1106, Vol. 22, no 2, p. 185-196Article in journal (Refereed)
    Abstract [en]

    In anesthetized cats 251 cells within the cortical vestibular projection area, adjacent to the post-cruciate dimple, were analyzed as to their input characteristics employing extracellular recording techniques. The post cruciate dimple vestibular field, which is located in area 3a, has a high degree of convergence between vestibular and peripheral somatosensory input. The latter is not restricted to muscle afferents but includes cutaneous modalities. The functional significance of this vestibular cortical projection field is discussed.

  • 25937.
    Ödkvist, Lars
    et al.
    Linköping University.
    Möller, C.
    Linköping University.
    Thell, Jan
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Hydén, Dag
    Linköping University.
    Gentamycin-treated Meniere's disease evaluated by rotatory tests1985In: Myers E, editor.; Elsevier SiencePublishers B.V.; 1985 / [ed] Myers E,, 1985, p. 43-44Conference paper (Other academic)
  • 25938.
    Ödkvist, Lars
    et al.
    Östergötlands Läns Landsting.
    Möller, Claes
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Vestibulr Compensation Measured by the Broad-Frequency Band Rotatory Test1987In: The Vestibular system: Neurophysiologic and clinical research / [ed] Malcolm D. Graham, John L. Kemink, New York: Raven Press , 1987, p. 287-291Conference paper (Refereed)
  • 25939.
    Ödkvist, Lars
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Noaksson, L M
    Greibe, Patrick
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Ledin, Torbjörn
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Oto-Rhiono-Laryngology and Head & Neck Surgery. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
    Neurootology in neck trauma patients2004In: Bárány Society XXIII International Congress,2004, 2004, p. 156-156Conference paper (Other academic)
  • 25940.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Edling, Christer
    Bergholtz, Lars
    Östergötlands Läns Landsting.
    Tidig diagnostik vid lösningsmedelsskada1982In: Sv Otolaryngol förening 1982;2, 1982, p. 2-Conference paper (Other academic)
  • 25941.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Aschan, Gunnar
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Hur inverkar industriella lösningsmedel på balansapparaten1978In: Läkaresällskapets riksstämma 1978, 1978Conference paper (Other academic)
  • 25942.
    Ödkvist, Lars
    et al.
    Linköping University.
    Tham, Richard
    Linköping University.
    Åhlfeldt, H.
    Linköping University.
    Andersson, Björn
    Linköping University.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University.
    Vestibulo-oculomotor findings during styrene exposure1981In: World Congress of Otolaryngol 1981, 1981Conference paper (Other academic)
  • 25943.
    Ödkvist, Lars
    et al.
    Linköping University.
    Thell, Jan
    Östergötlands Läns Landsting.
    Hydén, Dag
    Linköping University.
    Larsby, Birgitta
    Linköping University.
    Vascular cause for vertigo1986In: Claussen C-F, Kirtane MV, editors. Vertigo, nausea,tinnitus and hearing loss in cardiovasculr disease.: Elsevier SciencePublishers B.V.; 1986, 1986, p. 61-68Conference paper (Other academic)
  • 25944.
    Ödkvist, Lars
    et al.
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    Thell, Jan
    Östergötlands Läns Landsting. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    Larsby, Birgitta
    Linköping University. Department of Otolaryngology, University Hospital, Linköping, Sweden..
    A comparison between smooth pursuit and visual suppression1988In: Advances in Oto-Rhino-Laryngology, ISSN 0065-3071, E-ISSN 1662-2847, Vol. 41, p. 109-115Article in journal (Refereed)
  • 25945.
    Ödkvist, Lars
    et al.
    Linköping University.
    Åstrand, I.
    Arbetsmiljöinstitutet.
    Larsby, Birgitta
    Linköping University.
    Käll, K.
    Arbetsmiljöinstitutet.
    Ger lösningsmedel störningar i vestibulo-oculomotorsystemet ?1980In: Arbete och Hälsa, ISSN 0346-7821, Vol. 2, no 1Article in journal (Other academic)
  • 25946.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Technology in rotatory testing. 18th Bárány Society Meeting in Uppsala, June 6-8,1994.1994In: 18th Bárány Society Meeting in Uppsala, June 6-8,1994., 1994Conference paper (Other academic)
  • 25947.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Influence of industrial solvents on the vestibular system.1978In: World congress on otolaryngology 1978, Miami Beach, 1978, p. 275-Conference paper (Other academic)
  • 25948.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Nackafferenter and vestibularis. Sv Otolaryngol förening 1995;1:45-46.1995In: Sv Otolaryngol förening 1995, 1995, p. 45-46Conference paper (Other academic)
  • 25949.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Liedgren, Christer
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Integration mellan proprioception och N.Vestibularis i CNS.1974In: Läkaresällskapets riksstämma 1974., 1974Conference paper (Other academic)
  • 25950.
    Ödkvist, LM
    et al.
    Östergötlands Läns Landsting.
    Thell, Jan
    Östergötlands Läns Landsting.
    Bengtsson, Ann
    Östergötlands Läns Landsting.
    Larsby, Birgitta
    Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
    Vertigo in fibromyalgi1986In: In: Claussen C-F, Kirtane MV, editors. Vertigo,nausea, tinnitus and hearing loss in cardiovascular diseases.: Elsevier SciencePublishers B.V. 1986 / [ed] Claussen C-F, Kirtane MV, 1986, p. 429-433Conference paper (Other academic)
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