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  • 351.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Westin, Carl-Fredrik
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Harvard Medical School, Laboratory of Mathematics in Imaging (LMI).
    An Information Theoretic Approach to Optimal Q-space Sampling2014In: ISMRM-ESMRMB 2014, 2014Conference paper (Other academic)
  • 352.
    Knutsson, Hans
    et al.
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Westin, Carl-Fredrik
    Harvard School of Medicin.
    Charged Containers for Optimal 3D Q-space Sampling2013In: Proceedings of the International Society for Magnetic Resonance in Medicine annual meeting (ISMRM'13), International Society for Magnetic Resonance in Medicine ( ISMRM ) , 2013Conference paper (Other academic)
    Abstract [en]

    Conclusions: We have presented a novel method for generating evenly distributed samples in a part of q-space that can be pre- specified in a general way. We have demonstrated the feasibility for two shapes, a sphere and a cube. The results are interesting from several points of view. There is a market tendency for the samples to group in shells indicating that the present work may provide a preferable alternative to recently proposed shell-interaction schemes [9]. The distributions attained for the cube case are far from Cartesian, this may be an advantage in a sparse reconstruction, e.g. compressed sensing, setting.

  • 353.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Westin, Carl-Fredrik
    Harvard Medical School, USA .
    From Expected Propagator Distribution to Optimal Q-space Sample Metric2014In: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014: 17th International Conference, Boston, MA, USA, September 14-18, 2014, Proceedings, Part III / [ed] Polina Golland, Nobuhiko Hata, Christian Barillot, Joachim Hornegger, Robert Howe, Springer, 2014, p. 217-224Conference paper (Refereed)
    Abstract [en]

    We present a novel approach to determine a local q-space metric that is optimal from an information theoretic perspective with respect to the expected signal statistics. It should be noted that the approach does not attempt to optimize the quality of a pre-defined mathematical representation, the estimator. In contrast, our suggestion aims at obtaining the maximum amount of information without enforcing a particular feature representation.

    Results for three significantly different average propagator distributions are presented. The results show that the optimal q-space metric has a strong dependence on the assumed distribution in the targeted tissue. In many practical cases educated guesses can be made regarding the average propagator distribution present. In such cases the presented analysis can produce a metric that is optimal with respect to this distribution. The metric will be different at different q-space locations and is defined by the amount of additional information that is obtained when adding a second sample at a given offset from a first sample. The intention is to use the obtained metric as a guide for the generation of specific efficient q-space sample distributions for the targeted tissue.

  • 354.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Westin, Carl-Fredrik
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Laboratory of Mathematics in Imaging, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
    Monomial Phase: A Matrix Representation of Local Phase2014In: Visualization and Processing of Tensors and Higher Order Descriptors for Multi-Valued Data / [ed] Carl-Fredrik Westin, Anna Vilanova, Bernhard Burgeth, Springer, 2014, p. 37-73Chapter in book (Other academic)
    Abstract [en]

    Local phase is a powerful concept which has been successfully used in many image processing applications. For multidimensional signals the concept of phase is complex and there is no consensus on the precise meaning of phase. It is, however, accepted by all that a measure of phase implicitly carries a directional reference. We present a novel matrix representation of multidimensional phase that has a number of advantages. In contrast to previously suggested phase representations it is shown to be globally isometric for the simple signal class. The proposed phase estimation approach uses spherically separable monomial filter of orders 0, 1 and 2 which extends naturally to N dimensions. For 2-dimensional simple signals the representation has the topology of a Klein bottle. For 1-dimensional signals the new phase representation reduces to the original definition of amplitude and phase for analytic signals. Traditional phase estimation using quadrature filter pairs is based on the analytic signal concept and requires a pre-defined filter direction. The new monomial local phase representation removes this requirement by implicitly incorporating local orientation. We continue to define a phase matrix product which retains the structure of the phase matrix representation. The conjugate product gives a phase difference matrix in a manner similar to the complex conjugate product of complex numbers. Two motion estimation examples are given to demonstrate the advantages of this approach.

  • 355.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Westin, Carl-Fredrik
    n/a.
    Normalized Convolution: Technique for Filtering Incomplete and Uncertain Data1993Conference paper (Refereed)
  • 356.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, The Institute of Technology.
    Westin, Carl-Fredrik
    Harvard School of Medicin.
    Tensor Metrics and Charged Containers for 3D Q-space Sample Distribution2013In: Medical Image Computing and Computer-Assisted Intervention – MICCAI / [ed] Mori, K., Sakuma, I., Sato, Y., Barillot, C., Navab, N., Springer, 2013, p. 679-686Conference paper (Refereed)
    Abstract [en]

    This paper extends Jones’ popular electrostatic repulsion based algorithm for distribution of single-shell Q-space samples in two fundamental ways. The first alleviates the single-shell requirement en- abling full Q-space sampling. Such an extension is not immediately ob- vious since it requires distributing samples evenly in 3 dimensions. The extension is as elegant as it is simple: Add a container volume of the de- sired shape having a constant charge density and a total charge equal to the negative of the sum of the moving point charges. Results for spherical and cubic charge containers are given. The second extension concerns the way distances between sample point are measured. The Q-space samples represent orientation, rather than direction and it would seem appropri- ate to use a metric that reflects this fact, e.g. a tensor metric. To this end we present a means to employ a generalized metric in the optimization. Minimizing the energy will result in a 3-dimensional distribution of point charges that is uniform in the terms of the specified metric. The radi- cally different distributions generated using different metrics pinpoints a fundamental question: Is there an inherent optimal metric for Q-space sampling? Our work provides a versatile tool to explore the role of differ- ent metrics and we believe it will be an important contribution to further the continuing debate and research on the matter.

  • 357.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Westin, Carl-Fredrik
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Andersson, Mats
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Representing local structure using tensors II2011In: Proceedings of the 17th Scandinavian conference on Image analysis / [ed] Anders Heyden, Fredrik Kahl, Springer, 2011, p. 545-556Conference paper (Refereed)
    Abstract [en]

    Estimation of local spatial structure has a long history and numerous analysis tools have been developed. A concept that is widely recognized as fundamental in the analysis is the structure tensor. However, precisely what it is taken to mean varies within the research community. We present a new method for structure tensor estimation which is a generalization of many of it's predecessors. The method uses filter sets having Fourier directional responses being monomials of the normalized frequency vector, one odd order sub-set and one even order sub-set. It is shown that such filter sets allow for a particularly simple way of attaining phase invariant, positive semi-definite, local structure tensor estimates. We continue to compare a number of known structure tensor algorithms by formulating them in monomial filter set terms. In conclusion we show how higher order tensors can be estimated using a generalization of the same simple formulation.

  • 358.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Westin, Carl-Fredrik
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Andersson, Mats
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Structure Tensor Estimation: Introducing Monomial Quadrature Filter Sets2012In: New Developments in the Visualization and Processing of Tensor Fields / [ed] David H. Laidlaw, Anna Vilanova, Springer, 2012, p. 3-28Chapter in book (Other academic)
    Abstract [en]

       "Bringing together key researchers in disciplines ranging from visualization and image processing to applications in structural mechanics, fluid dynamics, elastography, and numerical mathematics, the workshop that generated this edited volume was the third in the successful Dagstuhl series. Its aim, reflected in the quality and relevance of the papers presented, was to foster collaboration and fresh lines of inquiry in the analysis and visualization of tensor fields, which offer a concise model for numerous physical phenomena. Despite their utility, there remains a dearth of methods for studying all but the simplest ones, a shortage the workshops aim to address. Documenting the latest progress and open research questions in tensor field analysis, the chapters reflect the excitement and inspiration generated  by this latest Dagstuhl workshop, held in July 2009. The topics they address range from applications of the analysis of tensor fields to purer research into their mathematical and analytical properties. They show how cooperation and the sharing of ideas and data between those engaged in pure and applied research can open new vistas in the study of tensor fields."--Publisher's website.

  • 359.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Wilson, Roland
    n/a.
    Granlund, Gösta H.
    Linköping University, Department of Electrical Engineering, Computer Vision . Linköping University, The Institute of Technology.
    Anisotropic Filtering Operations for Image Enhancement and their Relation to the Visual System1981In: Proceedings of IEEE Computer Society Conference on Pattern Recognition and Image Processing: Dallas, Texas, 1981Conference paper (Refereed)
  • 360.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Wilson, Roland
    University of Aston.
    Granlund, Gösta H.
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    Anisotropic Non-Stationary Image Estimation and its Applications: Part I. Restoration of Noisy Images1983In: IEEE Transactions on Communications, ISSN 0090-6778, E-ISSN 1558-0857, Vol. COM--31, no 3, p. 388-397Article in journal (Refereed)
    Abstract [en]

    A new form of image estimator, which takes account of linear features, is derived using a signal equivalent formulation. The estimator is shown to be a nonstationary linear combination of three stationary estimators. The relation of the estimator to human visual physiology is discussed. A method for estimating the nonstationary control information is described and shown to be effective when the estimation is made from noisy data. A suboptimal approach which is computationally less demanding is presented and used in the restoration of a variety of images corrupted by additive white noise. The results show that the method can improve the quality of noisy images even when the signal-to-noise ratio is very low.

  • 361.
    Knutsson, Hans
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Wilson, Roland
    n/a.
    Granlund, Gösta H.
    Linköping University, Department of Electrical Engineering, Computer Vision . Linköping University, The Institute of Technology.
    Content-Dependent Anisotropic Filtering of Images1981In: Proceedings of International Conference on Digital Signal Processing: Florence, Italy, 1981Conference paper (Refereed)
  • 362.
    Kohli, Sunil
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Moidu, Khalid
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Farrier, J
    MEDSIG Sysop Canada.
    Chowdhury, Shamsul
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Åhlfeldt, Hans
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Wigertz, Ove
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    A study of e-mail use on a health care bulletin board1992In: World Congress On Medical Informatics MEDINFO92,1992, Amsterdam: ElsivierScience Publ , 1992, p. 124-Conference paper (Refereed)
  • 363.
    Kohli, Sunil
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Sahlén, K.
    Linköping University, Faculty of Health Sciences.
    Löfman, Owe
    Linköping University, Faculty of Health Sciences.
    Sivertun, Åke
    Linköping University, Faculty of Health Sciences.
    Foldevi, Mats
    Linköping University, Department of Department of Health and Society, General Practice. Linköping University, Faculty of Health Sciences.
    Trell, Erik
    Linköping University, Department of Department of Health and Society, General Practice. Linköping University, Faculty of Health Sciences.
    Wigertz, Ove
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Individuals living in areas with high background radon: a GIS method to identify populations at risk1997In: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 53, no 2, p. 105-112Article in journal (Refereed)
    Abstract [en]

    Objective: to identify and link populations and individuals that live within high risk areas. Design: census registers and disease registers which contain data on individuals can only give aggregate statistics relating to postal code districts, town, county or state boundaries. However environmental risk factors rarely, if ever, respect these man-made boundaries. What is needed is a method to rapidly identify individuals who may live within a described area or region and to further identify the disease(s) occurring among these individuals and/or in these areas. Method: this paper describes a method for linking the standard registers available in Sweden, notably the residence-property addresses they contain and the geographical coordinate setting of these, to map the population as a point coverage. Using standard GIS methods this coverage could be linked, merged or intersected with any other map to create new subsets of population. Representation of populations down to the individual level by automatised spatialisation of available census data is in its simplicity a new informatics method which in the designated GIS medium adds a new power of resolution. Results: we demonstrate this using the radon maps provided by the local communes. The Swedish annual population registration records of 1991 for the county ofÖstergötland and the property register available at the Central Statistical Bureau of Sweden formed the main data sources. By coupling the address in the population register to the property register each individual was mapped to the centroid of a property. By intersecting the population coverage with the radon maps, the population living in high, normal or low risk areas was identified and then analysed and stratified by commune, sex and age. The resulting tables can be linked to other databases, e.g. disease registers, to visualise and analyse geographical and related patterns. The methodology can be adapted for use with any other environmental map or small area. It can also be expanded to the fourth dimension by linking likewise available migration information to generate immediately coordinate-set, accumulated exposition and similar data.

  • 364.
    Kohli, Sunil
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Sahlén, K.
    Sivertun, Åke
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Löfman, Owe
    Linköping University, Department of Department of Health and Society. Linköping University, Faculty of Health Sciences.
    Trell, Erik
    Linköping University, Department of Department of Health and Society, General Practice. Linköping University, Faculty of Health Sciences.
    Wigertz, Ove
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Distance from the primary health center: a GIS method to study geographical access to health care1995In: Journal of medical systems, ISSN 0148-5598, E-ISSN 1573-689X, Vol. 19, no 6, p. 425-436Article in journal (Refereed)
    Abstract [en]

    Aerial distance from the dependent Primary Health Center is a crude but objective measure of geographical accessibility to Primary Health care facilities. This report describes a method for calculation of distances between the PHC and the population it serves using the data available from the local health authorities and the Swedish Central Statistical Bureau. The Swedish annual population registration records of 1991 and the property register available with the Central Statistical Bureau of Sweden formed the main data sources. By coupling the address in the population register to the property register each individual was mapped to the centroid of a property. The location of the PHCs as well as the areas covered by each were obtained from the local health authorities and mapped. By intersecting the population coverage with the PHC coverage the population for each PHC area was identified. Subsequently the distance to the PHC was calculated for each individual (property centroid). The population maps so generated can be linked to other databases to visualize and analyze the spatial dimension of health and disease. The methodology can be adapted for use with postal code districts, census enumeration tracts, or any other small area.

  • 365.
    Krusinska, Eva
    et al.
    University of Wroclaw Poland.
    Babic, Ankica
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Statistical decision support inpatients with elevated routine laboratory liver tests1992In: European Society for Medical Decision Making, Fourth Biennal Conference,1992, 1992, p. 18-18Conference paper (Refereed)
  • 366.
    Krusinska, Eva
    et al.
    Univesity of Wroclaw Polen.
    Babic, Ankica
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Mathiesen, Ulrik
    Oskarshamn Hospital .
    Wigertz, Ove
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Bodemar, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
    Statistical decision support in patients with elevated routine laboratory liver tests1992In: Theoretical surgery, ISSN 0179-8669, Vol. 7, no 3, p. 153-153Article in journal (Refereed)
  • 367.
    Krusinska, Ewa
    et al.
    University of Wroclaw Poland .
    Babic, Ankica
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Comparision of the rough sets approach and probabilitic data analysis techniques on a common set of medical data1992In: Intelligent decision support. Handbook of applications and advances of the rough sets theory / [ed] Roman Słowiński, Dordrecht: Kluwer Acadmic Publishers , 1992, p. 81-95Chapter in book (Other academic)
  • 368.
    Krusinska, Ewa
    et al.
    University of Wroclaw .
    Babic, Ankica
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Chowdhury, Shamsul
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Wigertz, Ove
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Bodemar, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
    Integrated approach for designing medical decision support systems with knowledge extracted from clinical databases by statistical methods1991In: SCAMC,1991, MCGRAWHILL, Inc , 1991, p. 353-Conference paper (Refereed)
  • 369.
    Krusinska, Ewa
    et al.
    Dept of Mathemtics and iInformatics Paris.
    Babic, Ankica
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Mathiesen, Ulrik
    Oskarshamns hospital .
    Chowdhury, Shamsul
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Wigertz, Ove
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Bodemar, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
    Franzén, Lennart
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Pathology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
    A statistically rule-based decision support system for the management of patients with suspected liver disease1993In: Vol. 18, no 2, p. 113-130Article in journal (Refereed)
  • 370.
    Krusinska, Ewa
    et al.
    University of Wroclaw Poland.
    Babic, Ankica
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Mathiesen, Ulrik
    Oskarshamn Hospital .
    Franzén, Lennart
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Pathology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
    Foberg, Ulla
    Dept of Infectious diseases Linköping.
    Frydén, Aril
    Linköping University, Department of Molecular and Clinical Medicine.
    Bodemar, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
    Wigertz, Ove
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Empirical modelling versus commonly applied data analysis techniques as used for decision support in liver diseases1992In: MEDINFO92,1992, Amsterdam: Elsevier Science Publ , 1992, p. 949-Conference paper (Refereed)
  • 371.
    Krusinska, Ewa
    et al.
    University of Technology Wroclaw, Poland.
    Shahsavar, Nosrat
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Babic, Ankica
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Xiao-Ming, Gao
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Wigertz, Ove
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Chowdhury, Shamsul
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    A systematic approach to knowledge extraction and representation for medical decision support1993In: Int Open Workshop on Knowledge acquisition, representation and processing,1993, 1993, p. 47-Conference paper (Refereed)
  • 372.
    Krusinska, Ewa
    et al.
    Technical University of Wroclaw Poland.
    Shahsavar, Nosrat
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Babic, Ankica
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Xiao-Ming, Gao
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Wigertz, Ove
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Chowdhury, Shamsul
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    A systematic approach to knowledge extraction and representation for medical decision support1994In: Foundations of computing and decision sciences, ISSN 0867-6356, Vol. 19, no 1-2, p. 71-88Article in journal (Refereed)
  • 373.
    Kviklien, Adriana
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Simulations of bubble's non-linear response2002Report (Other (popular science, discussion, etc.))
  • 374.
    Köpsén, Kristian
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Improving visualisation of bronchi in three-dimensional rendering of CT data2007Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The medical imaging system Sectra PACS from Sectra Imtec contains a 3D mode that can be used for visualising image stacks from e.g. computed tomography. Various structures of human anatomy can be visualised in the 3D mode, but visualisations of the bronchial tree of the lungs rarely become good enough to be useful. The goal of this work was to investigate ways of improving such visualisations.

    Various approaches were studied, evaluated and tested. The fact that most effort was needed for small structures with sizes similar to the resolution of the images made things slightly more complicated. A method classifying neighbourhoods based on local structure emerged as most promising, and was used as foundation for a proposed algorithm. It creates a mask representing the presence of bronchi, allowing the hiding of uninteresting structures in its proximity. The algorithm was then implemented so that it could be tested together with the existing system.

    The method was found to work well and was able to detect the smaller tubes of the bronchial tree and output the desired classification mask. Its usefulness was somewhat reduced by issues relating to speed, and the fact that many computed tomography image stacks lack the necessary resolution for visualising the finer details of the bronchial tree.

  • 375.
    Landelius, Tomas
    et al.
    n/a.
    Haglund, Leif
    n/a.
    Knutsson, Hans
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Depth and Velocity from Orientation Tensor Fields1993In: SCIA8: Tromso, Norway, 1993Conference paper (Refereed)
    Abstract [en]

    This paper presents an algorithm for retrieving depth and velocity by estimating the 3D-orientation in an image sequence under the assumption of pure translation of the camera in a static scene. Quantitative error measurements are presented comparing the proposed algorithm to a gradient based optical flow algorithm.

  • 376.
    Langer, Max
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Design of Fast Multidimensional Filters by Genetic Algorithms2004Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The need for fast multidimensional signal processing arises in many areas. One of the more demanding applications is real time visualization of medical data acquired with e.g. magnetic resonance imaging where large amounts of data can be generated. This data has to be reduced to relevant clinical information, either by image reconstruction and enhancement or automatic feature extraction. Design of fast-acting multidimensional filters has been subject to research during the last three decades. Usually methods for fast filtering are based on applying a sequence of filters of lower dimensionality acquired by e.g. weighted low-rank approximation. Filter networks is a method to design fast multidimensional filters by decomposing multiple filters into simpler filter components in which coefficients are allowed to be sparsely scattered. Up until now, coefficient placement has been done by hand, a procedure which is time-consuming and difficult. The aim of this thesis is to investigate whether genetic algorithms can be used to place coefficients in filter networks. A method is developed and tested on 2-D filters and the resulting filters have lower distortion values while still maintaining the same or lower number of coefficients than filters designed with previously known methods.

  • 377.
    Langer, Max
    et al.
    Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
    Svensson, Björn
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Brun, Anders
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Andersson, Mats
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Knutsson, Hans
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Design of fast multidimensional filters using genetic algorithms2005In: Applications of Evolutionary Computing: EvoWorkkshops 2005: EvoBIO, EvoCOMNET, EvoHOT, EvoIASP, EvoMUSART, and EvoSTOC Lausanne, Switzerland, March 30 - April 1, 2005 Proceedings, Springer Berlin/Heidelberg, 2005, p. 366-375Conference paper (Refereed)
    Abstract [en]

    A method for designing fast multidimensional filters using genetic algorithms is described. The filter is decomposed into component filters where coefficients can be sparsely scattered using filter networks. Placement of coefficients in the filters is done by genetic algorithms and the resulting filters are optimized using an alternating least squares approach. The method is tested on a 2-D quadrature filter and the method yields a higher quality filter in terms of weighted distortion compared to other efficient implementations that require the same ammount of computations to apply. The resulting filter also yields lower weighted distortion than the full implementation.

  • 378.
    Larsson, Jonatan
    Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Implementation and evaluation of motion correction for quantitative MRI2010Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Image registration is the process of aligning two images such that their mutual features overlap. This is of great importance in several medical applications. In 2008 a novel method for simultaneous T1, T2 and proton density quantification was suggested. The method is in the field of quantitative Magnetic Resonance Imaging or qMRI. In qMRI parameters are quantified by a pixel-to-pixel fit of the image intensity as a function of different MR scanner settings. The quantification depends on several volumes of different intensities to be aligned. If a patient moves during the data aquisition the datasets will not be aligned and the results are degraded due to this. Since the quantification takes several minutes there is a considerable risk of patient movements. In this master thesis three image registration methods are presented and a comparison in robustness and speed was made. The phase based algorithm was suited for this problem and limited to finding rigid motion. The other two registration algorithms, originating from the Statistical Parametrical Mapping, SPM, package, were used as references. The result shows that the pixel-to-pixel fit is greatly improved in the datasets with found motion. In the comparison between the different methods the phase based algorithm turned out to be both the fastest and the most robust method.

  • 379.
    Lee, Dennis
    et al.
    University of Victoria, BC, Canada.
    de Keizer, Nicolette
    University of Amsterdam, The Netherlands .
    Lau, Francis
    University of Victoria, BC, Canada.
    Cornet, Ronald
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Literature review of SNOMED CT use2014In: JAMIA Journal of the American Medical Informatics Association, ISSN 1067-5027, E-ISSN 1527-974X, Vol. 21, no E1, p. E11-E19Article, review/survey (Refereed)
    Abstract [en]

    OBJECTIVE: The aim of this paper is to report on the use of the systematised nomenclature of medicine clinical terms (SNOMED CT) by providing an overview of published papers.

    METHODS: Published papers on SNOMED CT between 2001 and 2012 were identified using PubMed and Embase databases using the keywords 'systematised nomenclature of medicine' and 'SNOMED CT'. For each paper the following characteristics were retrieved: SNOMED CT focus category (ie, indeterminate, theoretical, pre-development/design, implementation and evaluation/commodity), usage category (eg, prospective content coverage, used to classify or code in a study), medical domain and country.

    RESULTS: Our search strategy identified 488 papers. A comparison between the papers published between 2001-6 and 2007-12 showed an increase in every SNOMED CT focus category. The number of papers classified as 'theoretical' increased from 46 to 78, 'pre-development/design' increased from 61 to 173 and 'implementation' increased from 10 to 34. Papers classified as 'evaluation/commodity' only started to appear from 2010.

    CONCLUSIONS: The majority of studies focused on 'theoretical' and 'pre-development/design'. This is still encouraging as SNOMED CT is being harmonized with other standardized terminologies and is being evaluated to determine the content coverage of local terms, which is usually one of the first steps towards adoption. Most implementations are not published in the scientific literature, requiring a look beyond the scientific literature to gain insights into SNOMED CT implementations.

  • 380.
    Leinhard, Olof Dahlqvist
    et al.
    Linköping University, Department of Medicine and Care, Radio Physics. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Faculty of Health Sciences.
    Johansson, Andreas
    Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.
    Rydell, Joakim
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Smedby, Örjan
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology in Linköping.
    Nystöm, Fredrik
    Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
    Lundberg, Peter
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology in Linköping.
    Borga, Magnus
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, The Institute of Technology.
    Quantitative Abdominal Fat Estimation Using MRI2008In: Proceedings - International Conference on Pattern Recognition, IEEE Computer Society, 2008, p. 1-4Conference paper (Refereed)
    Abstract [en]

    This paper introduces a new method for automaticquantification of subcutaneous, visceral and nonvisceralinternal fat from MR-images acquired usingthe two point Dixon technique in the abdominal region.The method includes (1) a three dimensionalphase unwrapping to provide water and fat images, (2)an image intensity inhomogeneity correction, and (3) amorphon based registration and segmentation of thetissue. This is followed by an integration of the correctedfat images within the different fat compartmentsthat avoids the partial volume effects associated withtraditional fat segmentation methods. The method wastested on 18 subjects before and after a period of fastfoodhyper-alimentation showing high stability andperformance in all analysis steps.

  • 381.
    Lidell, Martin E.
    et al.
    Medicinsk genetik, Göteborgs universitet.
    Betz, Matthias J.
    Medicinsk genetik, Göteborgs universitet.
    Dahlqvist Leinhard, Olof
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
    Heglind, Mikael
    Medicinsk genetik, Göteborgs universitet.
    Elander, Louise
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Slawik, Marc
    Klinikum der Ludwig Maximilians University (LMU), Munich, Germany.
    Mussack, Thomas
    Klinikum der LMU, Munich, Germany.
    Nilsson, Daniel
    Medicinsk genetik, Göteborgs universitet.
    Romu, Thobias
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Nuutila, Pirjo
    University of Turku, Turku, Finland.
    Virtanen, Kirsi A.
    University of Turku, Turku, Finland.
    Beuschlein, Felix
    Klinikum der Ludwig Maximilians University (LMU), Munich, Germany.
    Persson, Anders
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Radiology in Linköping.
    Borga, Magnus
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Enerbäck, Sven
    Medicinsk genetik, Göteborgs universitet.
    Evidence for two types of brown adipose tissue in humans2013In: Nature Medicine, ISSN 1078-8956, E-ISSN 1546-170X, Vol. 19, no 5, p. 631-634Article in journal (Refereed)
    Abstract [en]

    The previously observed supraclavicular depot of brown adipose tissue (BAT) in adult humans was commonly believed to be the equivalent of the interscapular thermogenic organ of small mammals. This view was recently disputed on the basis of the demonstration that this depot consists of beige (also called brite) brown adipocytes, a newly identified type of brown adipocyte that is distinct from the classical brown adipocytes that make up the interscapular thermogenic organs of other mammals. A combination of high-resolution imaging techniques and histological and biochemical analyses showed evidence for an anatomically distinguishable interscapular BAT (iBAT) depot in human infants that consists of classical brown adipocytes, a cell type that has so far not been shown to exist in humans. On the basis of these findings, we conclude that infants, similarly to rodents, have the bona fide iBAT thermogenic organ consisting of classical brown adipocytes that is essential for the survival of small mammals in a cold environment.

  • 382.
    Lidman, Linda
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Computer and Information Science, CSELAB - Cognitive Systems Engineering Laboratory.
    Babic, Ankica
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Arvola, Mattias
    Linköping University, The Institute of Technology. Linköping University, Department of Computer and Information Science, CSELAB - Cognitive Systems Engineering Laboratory.
    Lönn, Urban
    Thoraxkirurgi Uppsala.
    Defending clinician values: Quality-in-use of decision support systems for thoracic surgery2002In: Am Medic Inform Ass Annual Symposium,2002, 2002, p. 1082-1082Conference paper (Refereed)
    Abstract [en]

    The aims of the practical work carried out within this research were to redesign a clinical decision support system for thoracic surgeons, called AssistMe and to evaluate the concept behind this system.

  • 383.
    Lillehaug, Svein-Ivar
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Requirements for integrating effective decision support in hospital information systems1998In: International Consortium for Courseware Engineering,1998, 1998, p. 21-30Conference paper (Refereed)
  • 384.
    Lillehaug, Svein-Ivar
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Lajoie, Susanne
    McGill University,Montreal .
    AI in medical education - another grand challenge for medical informatics1998In: Artificial Intelligence in Medicine, ISSN 0933-3657, E-ISSN 1873-2860, Vol. 12, p. 197-225Article in journal (Refereed)
  • 385.
    Lillehaug, Svein-Ivar
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Lajoie, Susanne
    Mc Gill University Montreal.
    Health care workers and their needs: The forgottenshadow of AIM research1998In: MEDINFO 98,1998, Australia: IOS Press , 1998, p. 1232-Conference paper (Refereed)
  • 386.
    Lind, Leili
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Evaluation of the Use of Digital Pens for Pain Assessment in Palliative Home Healthcare2008In: Studies in Health Technology and Informatics, ISSN 0926-9630, E-ISSN 1879-8365, Vol. 136, p. 101-106Article in journal (Refereed)
    Abstract [en]

    An information system supporting pain assessment in palliative home healthcare was implemented at the hospital-based home care clinic of University Hospital in Linkoping, Sweden. Using digital pens and pain diaries, pain assessments were sent from the patients home to the professional caregiver. A total of 12 patients participated in the study. Patients, spouses and professional caregivers were interviewed. Qualitative content analyses were performed on the study material. All patients managed to use the pain assessment method, they experienced an improved contact with the caregivers and had a sense of increased security. After an initial cautious outlook the caregivers experienced positive outcomes for themselves and their patients. The medical records showed that the method had had impact on treatment. In conclusion, the home healthcare solution provided an effortless method for pain assessment with a high degree of user acceptance for palliative patients and had positive influences on the care.

  • 387.
    Lind, Leili
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    The use of information technology in home healthcare: requirements and application development2003Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    The population's wish to receive care in the own home instead of at a hospital fits well with the Health Services' development in the direction of increasing home healthcare even when severe illness is involved. However, when care is moved from the hospital to the home the demands for high quality care still remain. Information and telecommunication technologies used in applications which are tailored to support caregivers and patients in home healthcare, can be part of the facilitation of this development towards an increasing home healthcare service. Remote monitoring of the patient in the home can support assuring this quality of care but such monitoring involves considering several requirement areas.

    This thesis describes problem areas in both basic and advanced home healthcare where information technology can be a part of the solution. Further, the thesis describes requirement areas to be considered when monitoring patients in the home, both in regard to subjective and objective variables. The requirement areas, which are described in the thesis, include security, mobility, and responsibility. Network solutions for home healthcare are discussed and two information technology applications in home healthcare are described. The first application concerns diabetes care and the second application concerns the use of digital pen technology for symptom assessments in advanced palliative home healthcare.

    List of papers
    1. Requirements and prototyping of a home health care application based on emerging JAVA technology.
    Open this publication in new window or tab >>Requirements and prototyping of a home health care application based on emerging JAVA technology.
    Show others...
    2002 (English)In: International Journal of Medical Informatics, ISSN 1386-5056, Vol. 68, no 1-3, p. 129-139Article in journal (Refereed) Published
    Abstract [en]

    IT support for home health care is an expanding area within health care IT development. Home health care differs from other in- or outpatient care delivery forms in a number of ways, and thus, the introduction of home health care applications must be based on a rigorous analysis of necessary requirements to secure safe and reliable health care. This article reports early experiences from the development of a home health care application based on emerging technologies. A prototype application for the follow-up of diabetes patients is presented and discussed in relation to a list of general requirements on home health care applications.

    Keywords
    Home health care, Diabetes patients, Requirements, Monitoring, JAVA technology
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14167 (URN)10.1016/S1386-5056(02)00071-0 (DOI)
    Available from: 2006-11-30 Created: 2006-11-30 Last updated: 2013-11-13
    2. Network solutions for home health care applications
    Open this publication in new window or tab >>Network solutions for home health care applications
    2003 (English)In: Technology and Health Care, ISSN 0928-7329, E-ISSN 1878-7401, Vol. 11, no 2, p. 77-87Article in journal (Refereed) Published
    Abstract [en]

    The growing number of the elderly in industrialised countries is increasing the pressure on respective health care systems. This is one reason for recent trends in the development and expansion of home health care organisations. With Internet access available to everyone and the advent of wireless technologies, advanced telehomecare is a possibility for a large proportion of the population.

    In the near future, one of the authors plans to implement a home health care infrastructure for patients with congestive heart failure and patients with chronic obstructive pulmonary disease. The system is meant to support regular and ad-hoc measurements of medical parameters in patient homes and transmission of measurement data to the home health care provider.

    In this paper we look at network technologies that connect sensors and input devices in the patient home to a home health care provider. We consider wireless and Internet technologies from functional and security-related perspectives and arrive at a recommendation for our system.

    Security and usability aspects of the proposed network infrastructures are explored with special focus on their impact on the patient home.

    National Category
    Computer Sciences
    Identifiers
    urn:nbn:se:liu:diva-24386 (URN)6479 (Local ID)6479 (Archive number)6479 (OAI)
    Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2018-01-13
    3. Symptom assessment in palliative advanced home healthcare using digital pens
    Open this publication in new window or tab >>Symptom assessment in palliative advanced home healthcare using digital pens
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Symptom control is one of the most important components of delivering effective palliative care, and adequate symptom assessment is a prerequisite for good symptom control. Patient receiving treatment in palliative home healthcare is geographically separated from the caregivers making symptom control a challenge, a challenge that could be met by the use of information and communication technology.

    This paper describes experiences from a project focused on symptom assessment using digital pen technology in advanced palliative home healthcare. As part of an ongoing quality assurance work within the hospital-based home care clinic at Linköping University Hospital, the project has designed, developed and implemented an IT-support system for pain assessments for patients at home using digital pen technology. The system uses mobile Internet technology together with digital pen technology from Anoto™ AB. From December 2002 to August 2003 the system was in use at the hospital-based home care clinic. Alternative techniques, for example the use of a PC or a touch-tone telephone for symptom assessment, are discussed.

    Keywords
    Digital Pens; Computer Terminals; Cellular Phones; Internet; Home Care Services, Hospital-Based
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-100837 (URN)
    Available from: 2013-11-13 Created: 2013-11-13 Last updated: 2013-11-13
  • 388.
    Lind, Leili
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Towards Effortless Use of Information Technology in Home Healthcare with a Networked Digital Pen2007In: Anoto Functionality Conference 2007,2007, 2007Conference paper (Other academic)
  • 389.
    Lind, Leili
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Towards Effortless Use of Information Technology in Home Healthcare with a Networked Digital Pen2006Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    When care is moved from the hospital to the home the demands for high quality care still remain. For problems arising from the geographical separation of patients and professional caregivers, information and communication technology may offer important solutions. The overall aim of this thesis was to describe relevant requirements, to design and implement an IT-based system, and finally to evaluate the system’s influence on symptom control and support for both patients/next-of-kin and professional caregivers in advanced home healthcare. Of importance were needs in basic as well as advanced home healthcare, as were usability perspectives of both patients and professional caregivers. Requirement areas such as security, mobility, and responsibility, which should be considered when monitoring patients in the home, were identified. A prototype system for everyday assistance for diabetes patients was designed, and a system for frequent pain assessment for palliative home healthcare patients using a pain diary, digital pen and mobile Internet technology, was developed and evaluated through a qualitative content analysis approach. Twelve palliative cancer patients and six professional caregivers participated. The data collected included an ease-of-use questionnaire, and interviews with patients, spouses and professional caregivers. Patients expressed increased and improved contact with the caregivers, increased participation in their own care, a sense of increased security, and easiness in using the equipment in spite of severe illness and difficulties in comprehending the technology and system intervention. The professional caregivers showed a shifting outlook towards the pain assessment method; an initial cautious outlook due to low expectations of the patients’ abilities to use the pain assessment method and the caregivers’ own reluctance to use the system and change their way-of-working. Despite this, the professional caregivers experienced positive outcomes in terms of an increased awareness of pain, and positive patient influences including increased participation in their care, increased security and improved changes in pain treatment as a response to reported pain assessments. In conclusion, the networked digital pen system provided an effortless method for pain assessment and had positive influences on the care. The results imply that digital pen technology is suitable for the assessment of symptoms by palliative patients since these patients often have a limited capacity to handle technology due to their state of health.

    List of papers
    1. Requirements and prototyping of a home health care application based on emerging JAVA technology.
    Open this publication in new window or tab >>Requirements and prototyping of a home health care application based on emerging JAVA technology.
    Show others...
    2002 (English)In: International Journal of Medical Informatics, ISSN 1386-5056, Vol. 68, no 1-3, p. 129-139Article in journal (Refereed) Published
    Abstract [en]

    IT support for home health care is an expanding area within health care IT development. Home health care differs from other in- or outpatient care delivery forms in a number of ways, and thus, the introduction of home health care applications must be based on a rigorous analysis of necessary requirements to secure safe and reliable health care. This article reports early experiences from the development of a home health care application based on emerging technologies. A prototype application for the follow-up of diabetes patients is presented and discussed in relation to a list of general requirements on home health care applications.

    Keywords
    Home health care, Diabetes patients, Requirements, Monitoring, JAVA technology
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14167 (URN)10.1016/S1386-5056(02)00071-0 (DOI)
    Available from: 2006-11-30 Created: 2006-11-30 Last updated: 2013-11-13
    2. A system for symptom assessment in advanced palliative home healthcare using digital pens.
    Open this publication in new window or tab >>A system for symptom assessment in advanced palliative home healthcare using digital pens.
    2004 (English)In: Medical informatics and the Internet in medicine, ISSN 1463-9238, Vol. 29, no 3-4, p. 199-210Article in journal (Refereed) Published
    Abstract [en]

    Symptom control is one of the most important components of delivering effective palliative care, and adequate symptom assessment is a prerequisite for good symptom control. Patients receiving treatment in palliative home healthcare is geographically separated from the caregivers making symptom control a challenge, a challenge that could be met by the use of information and communication technology. Technologies of today offer different ways for patients to assess their symptoms at home and send the assessments to the healthcare provider. Examples are the use of a PC, a touch-tone telephone, and a digital pen, which require different kinds of infrastructure in the patient's home, and which differ in strengths and weaknesses. As part of an ongoing quality assurance work within the hospital-based home care clinic at Linköping University Hospital, the project has designed, developed and implemented an IT-support system for pain assessments for patients at home using digital pen and mobile Internet technology. A questionnaire study indicated that pain assessment using digital pens was accepted by patients and that problems mainly arose from the use of the visual-analogue scale.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14168 (URN)10.1080/14639230400005966 (DOI)
    Available from: 2006-11-30 Created: 2006-11-30 Last updated: 2009-05-25
    3. Patients’ use of digital pens for pain assessment in advanced palliative home healthcare.
    Open this publication in new window or tab >>Patients’ use of digital pens for pain assessment in advanced palliative home healthcare.
    2008 (English)In: International Journal of Medical Informatics, ISSN 1386-5056, E-ISSN 1872-8243, Vol. 77, no 2, p. 129-136Article in journal (Refereed) Published
    Abstract [en]

    Background: Appropriate pain assessment is a necessary prerequisite for adequate pain control. A way to follow-up on the pain is to let patients use paper-based or electronic pain diaries.

    Purpose: The aim was to explore and describe palliative home care patients’ experiences of assessing their pain by using a pain diary together with digital pen and mobile Internet technology.

    Methods: A system for the follow-up of pain treatment was developed and evaluated by means of a qualitative cross-case content analysis. From December 2002 until September 2003 12 palliative patients, who initially assessed VAS pain ≥ 35 mm (VAS 0–100 mm), used the system. Patients reported their momentary pain intensity and the number of consumed extra doses of analgesics three times per day. Analysis data were collected from interviews with patients and spouses, questionnaires, medical records, and the system log.

    Results: In spite of severe illness and difficulties in comprehending the technology and system intervention, patients found the pain diary and digital pen easy to use for pain assessment. Patients took a greater part in their own care and experienced an improved contact with their caregivers, which led to a sense of increased security. The medical records showed a quick response to variations in the patients’ health status by means of changes in medical treatment.

    Conclusions: The pain assessment system for palliative patients using pain diaries together with digital pen and wireless Internet technology constitutes an effortless method and has positive influences on the care.

    Keywords
    Pain assessment; Visual analogue scale; Palliative care; Home care services, Hospital-based; Digital pens; Mobile phones; Internet
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14169 (URN)10.1016/j.ijmedinf.2007.01.013 (DOI)
    Available from: 2006-11-30 Created: 2006-11-30 Last updated: 2017-12-13
    4. Digital pens and pain diaries in palliative home healthcare: Professional caregivers’ experiences.
    Open this publication in new window or tab >>Digital pens and pain diaries in palliative home healthcare: Professional caregivers’ experiences.
    2007 (English)In: Medical Informatics and the Internet in Medicine, ISSN 1753-8157, Vol. 32, no 4, p. 287-296Article in journal (Refereed) Published
    Abstract [en]

    Frequent pain assessment by the use of pain diaries for the follow-up of pain treatment can facilitate the caregivers' work with pain control in home health care. The aim was to explore and describe professional caregivers' experiences of palliative home health-care patients' use of pain diaries and digital pen technology for frequent pain assessment. A system for the follow-up of pain treatment was implemented in routine care and evaluated by means of a qualitative content analysis. Three nurses, two physicians and one secretary were interviewed. Additional analysis data were collected from patients' medical records, and the system log. The caregivers showed a shifting outlook towards the pain-assessment method, an initial cautious outlook due to low expectations of the patients' abilities to use the pain assessment method. Despite this, the caregivers experienced positive outcomes in terms of an increased awareness of pain, and positive patient influences including increased participation in their care, increased security, and improved changes in pain treatment as a response to reported pain assessments. Pain assessment by the use of pain diaries and digital pen technology has positive influences on palliative home-care patients and supports the caregivers' focus on the pain.

    Keywords
    Pain assessment; home care services, hospital-based; digital pens; mobile phones; Internet
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14170 (URN)10.1080/14639230701785381 (DOI)
    Available from: 2006-11-30 Created: 2006-11-30
  • 390.
    Lind, Leili
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Berglund, Aseel
    Saab Aerosystems, Linköping.
    Berglund, Erik
    Linköping University, Department of Computer and Information Science, MDALAB - Human Computer Interfaces. Linköping University, The Institute of Technology.
    Bång, Magnus
    Linköping University, Department of Computer and Information Science, MDALAB - Human Computer Interfaces. Linköping University, The Institute of Technology.
    Hägglund, Sture
    Linköping University, Department of Computer and Information Science, MDALAB - Human Computer Interfaces. Linköping University, The Institute of Technology.
    Effortless data capture for ambient e-services with digital pen and paper technology2010In: Designing Solution-Based Ubiquitous and Pervasive Computing: New Issues and Trends / [ed] Fransisco Milton Mendes Neto, Pedro Fernandes Ribeiro Neto, Information Science Publishing/IGI Global , 2010, p. 24-43Chapter in book (Other academic)
    Abstract [en]

    In order to counteract the digital divide and to enable the society to reach all its citizens with various kinds of e-services, there is a need to develop access methods and terminal technologies suited also for groups with weak access to the Internet, not the least elderly and people needing care in their homes. In this chapter, the authors will describe technologies for using digital pen and paper as data input media for e-services and computing applications, refer a number of applications together with studies and evaluations of their usability, and finally comment upon future prospects for integrating digital pen and paper as an effortless technique for data capture, especially in order to counteract and diminish the digital divide. The use of digital pen and paper technologies is exemplified with applications demonstrating its appropriateness in home care for elderly, for free-form recording of data on paper such as maps, and as a remote control for a TV set or other electronic appliances with rich functionality in the home.

  • 391.
    Lind, Leili
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering. SICS East Swedish ICT, Linköping, Sweden.
    Carlgren, Gunnar
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Advanced Home Care in Linköping.
    Karlsson, Daniel
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering.
    Old-and With Severe Heart Failure: Telemonitoring by Using Digital Pen Technology in Specialized Homecare: System Description, Implementation, and Early Results2016In: Computers, Informatics, Nursing, ISSN 1538-2931, E-ISSN 1538-9774, Vol. 34, no 8, p. 360-368Article in journal (Refereed)
    Abstract [en]

    Telehealth programs for heart failure have been studied using a variety of techniques. Because currently a majority of the elderly are nonusers of computers and Internet, we developed a home telehealth system based on digital pen technology. Fourteen patients (mean age, 84 years [median, 83 years]) with severe heart failure participated in a 13-month pilot study in specialized homecare. Participants communicated patient-reported outcome measures daily using the digital pen and health diary forms, submitting a total of 3 520 reports. The reports generated a total of 632 notifications when reports indicated worsening health. Healthcare professionals reviewed reports frequently, more than 4700 times throughout the study, and acted on the information provided. Patients answered questionnaires and were observed in their home environment when using the system. Results showed that the technology was accepted by participants: patients experienced an improved contact with clinicians; they felt more compliant with healthcare professionals advice, and they felt more secure and more involved in their own care. Via the system, the healthcare professionals detected heart failure-related deteriorations at an earlier stage, and as a consequence, none of the patients were admitted into hospital care during the study.

  • 392.
    Lind, Leili
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering. SICS East Swedish ICT, Linköping, Sweden.
    Carlgren, Gunnar
    Region Östergötland, Local Health Care Services in Central Östergötland, Department of Advanced Home Care in Linköping.
    Mudra, Jacqueline
    Region Östergötland, Local Health Care Services in Central Östergötland, Department of Advanced Home Care in Linköping.
    Synnergren, Henrik
    Region Östergötland, Local Health Care Services in Central Östergötland, Department of Advanced Home Care in Linköping.
    Hilding, Niclas
    Region Östergötland, Local Health Care Services in Central Östergötland, Department of Advanced Home Care in Linköping.
    Karlsson, daniel
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering.
    Wiréhn, Ann-Britt
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in West Östergötland, Research & Development Unit in Local Health Care.
    Persson, Hans Lennart
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Respiratory Medicine.
    Preliminary results of a telemonitoring study: COPD and heart failure patients exhibit great difference in their need of health care2015In: European Respiratory Journal: Official Scientific Journal of ERS / [ed] Marc Humbert, European Respiratory Society , 2015, Vol. 46/suppl 59, p. PA2790-PA2790Conference paper (Other academic)
    Abstract [en]

    Background: Growing populations of elderly patients with advanced stages of COPD or heart failure (HF) urge the need for specialized health care in the patients' home. A telemonitoring study has been initiated including patients using digital pens. Health care was provided by the specialized home care unit at a university hospital. Through an IT system the staff checked all daily patient reports. We hypothesized that the two groups of patients, advanced COPD or HF, would exhibit differences regarding exacerbations and the need of health care.

    Objective: To study exacerbations of COPD or HF, and patient health care consumption.

    Methods: A tele-monitoring system, the Health diary, which is based on digital pen technology, was employed. Exacerbations were identified using information provided through the telemonitoring system. Consumed health care was assessed as the number of patient contacts (home visits or telephone consultations).

    Results: Presently, 33 patients with advanced disease are enrolled (13 COPD and 20 HF patients) of which 11 patients (6 COPD and 5 HF patients) have completed the 1-yr study period or have died during the study period (2 COPD and 4 HF patients). Exacerbations were 2.8 and 0.8 and patient contacts were 96 and 42 per COPD and HF patient, respectively. While HF patients were significantly older than COPD patients, the two groups demonstrated no difference regarding gender distribution and comorbidity.

    Conclusions: COPD patients exhibit exacerbations more frequently and demand much more home health care than patients with HF do. It seems that this difference of health care consumption is mainly due to disease characteristics.

  • 393.
    Lind, Leili
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Karlsson, Daniel
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    A system for symptom assessment in advanced palliative home healthcare using digital pens.2004In: Medical informatics and the Internet in medicine, ISSN 1463-9238, Vol. 29, no 3-4, p. 199-210Article in journal (Refereed)
    Abstract [en]

    Symptom control is one of the most important components of delivering effective palliative care, and adequate symptom assessment is a prerequisite for good symptom control. Patients receiving treatment in palliative home healthcare is geographically separated from the caregivers making symptom control a challenge, a challenge that could be met by the use of information and communication technology. Technologies of today offer different ways for patients to assess their symptoms at home and send the assessments to the healthcare provider. Examples are the use of a PC, a touch-tone telephone, and a digital pen, which require different kinds of infrastructure in the patient's home, and which differ in strengths and weaknesses. As part of an ongoing quality assurance work within the hospital-based home care clinic at Linköping University Hospital, the project has designed, developed and implemented an IT-support system for pain assessments for patients at home using digital pen and mobile Internet technology. A questionnaire study indicated that pain assessment using digital pens was accepted by patients and that problems mainly arose from the use of the visual-analogue scale.

  • 394.
    Lind, Leili
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Karlsson, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Digital pen technology in palliative home healthcare2004In: 11th World Congress on Medical Informatics MEDINFO04,2004, San Francisco: IOS Press , 2004, p. 1723-Conference paper (Refereed)
  • 395.
    Lind, Leili
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Karlsson, Daniel
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Digital pen-based telemonitoring of elderly heart failure patients2013In: Studies in Health Technology and Informatics, ISSN 0926-9630, E-ISSN 1879-8365, Vol. 192, p. 1062-1062Article in journal (Refereed)
    Abstract [en]

    Considering that a majority of elderlies are non-users of computers and Internet we developed a telemonitoring system for elderly heart failure (HF) home care patients based on digital pen technology - a technology never used before by this patient group. We implemented the system in clinical use in a 13 months long study. Fourteen patients (mean/median age 84 years) with severe HF participated. They accepted the technology and performed daily reports of their health state using the digital pen and a Health Diary form. Via the system the clinicians detected all HF-related deteriorations at an early stage and thereby prevented hospital re-admissions for all patients during the study, implying improved symptom control and large cost savings.

  • 396.
    Lind, Leili
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology. Santa Anna IT Research Institute, Linköping, Sweden.
    Karlsson, Daniel
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Electronic patient-reported symptom assessment in palliative end-of-life home care2013In: Health Systems, ISSN 2047-6965, E-ISSN 2047-6973, Vol. 2, no 3, p. 171-180Article in journal (Refereed)
    Abstract [en]

    Good symptom control in palliative end-of-life home care requires adequateaccess to patients’ symptom assessments. The aim of the study was to investigatethe feasibility of an electronic symptom assessment reporting system tosupport symptom control. A randomised controlled study was performedduring April 2008–December 2009. The intervention consisted of a networkeddigital-pen-based information system. The primary outcome measure chosenwas the time span from the patient’s reporting of a symptom to the careproviders’ noticing this assessment. Patients with at least moderately severesymptoms were invited to participate in the study. Eighteen (11 intervention,seven control) patients from four home care centres participated, submittinga total of 330 symptom assessments. There was a significantly shorter mediantime span from reporting to noticing for assessments in the intervention group.The system used allowed both frequent and regular symptom reporting frompatients that can contribute to more correct and prompt medical decisions inpalliative end-of-life home care. Trial registration number: ISRCTN09750271.Health Systems (2013) 2, 171–180. doi:10.1057/hs.2013.4;published online 17 May 2013; corrected online 4 June 2013

  • 397.
    Lind, Leili
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Karlsson, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Home healthcare patients using digital pens for pain assessment: in Telemedicine journal and e-health(ISSN 1530-5627) vol 11, issue 22005Conference paper (Refereed)
  • 398.
    Lind, Leili
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Karlsson, Daniel
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Medical Informatics.
    Symptom assessment in home healthcare using digital pens2003In: AMIA05,2003, 2003, p. 914-Conference paper (Refereed)
  • 399.
    Lind, Leili
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Karlsson, Daniel
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, The Institute of Technology.
    Symptom assessment in palliative advanced home healthcare using digital pensManuscript (preprint) (Other academic)
    Abstract [en]

    Symptom control is one of the most important components of delivering effective palliative care, and adequate symptom assessment is a prerequisite for good symptom control. Patient receiving treatment in palliative home healthcare is geographically separated from the caregivers making symptom control a challenge, a challenge that could be met by the use of information and communication technology.

    This paper describes experiences from a project focused on symptom assessment using digital pen technology in advanced palliative home healthcare. As part of an ongoing quality assurance work within the hospital-based home care clinic at Linköping University Hospital, the project has designed, developed and implemented an IT-support system for pain assessments for patients at home using digital pen technology. The system uses mobile Internet technology together with digital pen technology from Anoto™ AB. From December 2002 to August 2003 the system was in use at the hospital-based home care clinic. Alternative techniques, for example the use of a PC or a touch-tone telephone for symptom assessment, are discussed.

  • 400.
    Lind, Leili
    et al.
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering. SICS East Swedish ICT, Linköping, Sweden.
    Karlsson, Daniel
    Linköping University, Department of Biomedical Engineering, Medical Informatics. Linköping University, Faculty of Science & Engineering.
    Telehealth for “the Digital Illiterate”: Elderly Heart Failure Patients’ Experiences2014In: eHealth – For Continuity of Care: Proceedings of MIE2014 / [ed] Lovis, C., Séroussi, B., Hasman, A., Pape-Haugaard, L., Saka, O., Andersen, S.K., Amsterdam, Netherlands: IOS Press, 2014, Vol. 205, p. 353-357Conference paper (Refereed)
    Abstract [en]

    Telehealth solutions should be available also for elderly patients with nointerest in using, or capacity to use, computers and smartphones. Fourteen elderly,severely ill heart failure patients in home care participated in a telehealth study andused digital pens for daily reporting of their health state—a technology never usedbefore by this patient group. After the study seven patients and two spouses wereinterviewed face-to-face. A qualitative content analysis of the interview materialwas performed. The informants had no experience of computers or the Internet andno interest in learning. Still, patients found the digital pen and the health diaryform easy to use, thus effortlessly adopting to changes in care provision. Theyexperienced an improved contact with the caregivers and had a sense of increasedsecurity despite a multimorbid state. Our study shows that, given that technologiesare tailored to specific patient groups, even “the digital illiterate” may use theInternet.

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