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  • 351.
    Alexandersson, Henrik
    et al.
    Linköpings universitet, Institutionen för datavetenskap.
    Bouganim, Jakob
    Linköpings universitet, Institutionen för datavetenskap.
    Do Ruibin, Kevin
    Linköpings universitet, Institutionen för datavetenskap.
    Gunnarsson, Daniel
    Linköpings universitet, Institutionen för datavetenskap.
    Hyllienmark, Erik
    Linköpings universitet, Institutionen för datavetenskap.
    Karlsson, Anton
    Linköpings universitet, Institutionen för datavetenskap.
    Nathanaelsson, Sara
    Linköpings universitet, Institutionen för datavetenskap.
    Ringqvist, Hugo
    Linköpings universitet, Institutionen för datavetenskap.
    En studie kring utvecklingen av webbapplikationen HappyBox2017Självständigt arbete på grundnivå (kandidatexamen), 12 poäng / 18 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Syftet med rapporten var att undersöka hur en e-­butik för matvarupaket kunde utformas och implementeras för att vara användbar avseende navigerbarhet, samtidigt som den inger förtroende hos användaren och uppmuntrar till kundengagemang. Utifrån en förstudie kartlades intresset för produkten. Därefter utvecklades en prototyp och webbapplikationens design utformades. Utvecklingen skedde genom ett iterativt arbetssätt och frågeställningens beståndsdelar testades kontinuerligt i form av användbarhetstester. Rapporten presenterar och diskuterar webbapplikationens design och hur den använts i försök att uppfylla syftet. Även tekniska lösningar avseende utformandet av webbapplikationen diskuteras och motiveras. Slutligen argumenterar rapporten för hur feedback och tydliga knappar gör webbapplikationen förtroendeingivande och navigerbar. Slutsatser kring huruvida webbapplikationen uppmuntrar till kundengagemang har varit svåra att dra och författarna har därför avstått från detta.

  • 352.
    Alexander-Webber, J. A.
    et al.
    University of Oxford, England; University of Cambridge, England.
    Huang, J.
    University of Oxford, England.
    Maude, D. K.
    CNRS UGA UPS INSA, France.
    Janssen, T. J. B. M.
    National Phys Lab, England.
    Tzalenchuk, A.
    National Phys Lab, England; Royal Holloway University of London, England.
    Antonov, V.
    Royal Holloway University of London, England.
    Yager, T.
    Chalmers, Sweden.
    Lara-Avila, S.
    Chalmers, Sweden.
    Kubatkin, S.
    Chalmers, Sweden.
    Yakimova, Rositsa
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Halvledarmaterial. Linköpings universitet, Tekniska fakulteten.
    Nicholas, R. J.
    University of Oxford, England.
    Giant quantum Hall plateaus generated by charge transfer in epitaxial graphene2016Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 6, nr 30296Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Epitaxial graphene has proven itself to be the best candidate for quantum electrical resistance standards due to its wide quantum Hall plateaus with exceptionally high breakdown currents. However one key underlying mechanism, a magnetic field dependent charge transfer process, is yet to be fully understood. Here we report measurements of the quantum Hall effect in epitaxial graphene showing the widest quantum Hall plateau observed to date extending over 50 T, attributed to an almost linear increase in carrier density with magnetic field. This behaviour is strong evidence for field dependent charge transfer from charge reservoirs with exceptionally high densities of states in close proximity to the graphene. Using a realistic framework of broadened Landau levels we model the densities of donor states and predict the field dependence of charge transfer in excellent agreement with experimental results, thus providing a guide towards engineering epitaxial graphene for applications such as quantum metrology.

  • 353.
    Alexandre, Campos
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Apraiz, Itzaso
    Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
    da Fonseca, Rute R
    The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
    Cristobal, Susana
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
    Shotgun analysis of the marine mussel Mytilus edulis hemolymph proteome and mapping the innate immunity elements.2015Ingår i: Proteomics, ISSN 1615-9853, E-ISSN 1615-9861, Vol. 15, nr 23-24, s. 4021-4029Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The marine mussel innate immunity provides protection to pathogen invasion and inflammation.In this regard, the mussel hemolymph takes a main role in the animal innate response.Despite the importance of this body fluid in determining the physiological condition of theanimal, little is known about the molecular mechanisms underlying the cellular and humoralresponses. In this work, we have applied aMS (nano-LC-MS/MS) strategy integrating genomicand transcriptomic data with the aim to: (i) identify the main protein functional groups thatcharacterize hemolymph and (ii) to map the elements of innate immunity in the marine musselMytilus edulis hemolymph proteome. After sample analysis and first protein identificationbased onMS/MS data comparison, proteins with unknown functions were annotated with blastusing public database (nrNCBI) information. Overall 595 hemolymph proteins were identifiedwith high confidence and annotated. These proteins encompass primary cellular metabolicprocesses: energy production and metabolism of biomolecules, as well as processes related tooxidative stress defence, xenobiotic detoxification, drug metabolism, and immune response.A group of proteins was identified with putative immune effector, receptor, and signalingfunctions in M. edulis. Data are available via ProteomeXchange with identifier PXD001951(http://proteomecentral.proteomexchange.org/dataset/PXD001951).

  • 354.
    Alexsson, Andrei
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik.
    Unsupervised hidden Markov model for automatic analysis of expressed sequence tags2011Självständigt arbete på avancerad nivå (masterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    This thesis provides an in-depth analyze of expressed sequence tags (EST) that represent pieces of eukaryotic mRNA by using unsupervised hidden Markov model (HMM). ESTs are short nucleotide sequences that are used primarily for rapid identificationof new genes with potential coding regions (CDS). ESTs are made by sequencing on double-stranded cDNA and the synthesizedESTs are stored in digital form, usually in FASTA format. Since sequencing is often randomized and that parts of mRNA contain non-coding regions, some ESTs will not represent CDS.It is desired to remove these unwanted ESTs if the purpose is to identifygenes associated with CDS. Application of stochastic HMM allow identification of region contents in a EST. Softwares like ESTScanuse HMM in which a training of the HMM is done by supervised learning with annotated data. However, because there are not always annotated data at hand this thesis focus on the ability to train an HMM with unsupervised learning on data containing ESTs, both with and without CDS. But the data used for training is not annotated, i.e. the regions that an EST consists of are unknown. In this thesis a new HMM is introduced where the parameters of the HMM are in focus so that they are reasonablyconsistent with biologically important regionsof an mRNA such as the Kozak sequence, poly(A)-signals and poly(A)-tails to guide the training and decoding correctly with ESTs to proper statesin the HMM. Transition probabilities in the HMMhas been adapted so that it represents the mean length and distribution of the different regions in mRNA. Testing of the HMM's specificity and sensitivityhave been performed via BLAST by blasting each EST and compare the BLAST results with the HMM prediction results.A regression analysis test shows that the length of ESTs used when training the HMM is significantly important, the longer the better. The final resultsshows that it is possible to train an HMM with unsupervised machine learning but to be comparable to supervised machine learning as ESTScan, further expansion of the HMM is necessary such as frame-shift correction of ESTs byimproving the HMM's ability to choose correctly positioned start codons or nucleotides. Usually the false positive results are because of incorrectly positioned start codons leadingto too short CDS lengths. Since no frame-shift correction is implemented, short predicted CDS lengths are not acceptable and is hence not counted as coding regionsduring prediction. However, when there is a lack of supervised models then unsupervised HMM is a potential replacement with stable performance and able to be adapted forany eukaryotic organism.

  • 355.
    Alfirevic, Ana
    et al.
    University of Liverpool, UK.
    Gonzalez-Galarza, Faviel
    University of Liverpool, UK.
    Bell, Catherine
    University of Liverpool, UK.
    Martinsson, Klara
    University of Liverpool, UK.
    Platt, Vivien
    University of Liverpool, UK.
    Bretland, Giovanna
    University of Liverpool, UK.
    Evely, Jane
    University of Liverpool, UK.
    Lichtenfels, Maike
    University of Liverpool, UK.
    Cederbrant, Karin
    Safety Assessment, AstraZeneca, Gartuna, Södertälje, Sweden.
    French, Neil
    University of Liverpool, UK.
    Naisbitt, Dean
    University of Liverpool, UK.
    Park, B Kevin
    University of Liverpool, UK.
    Jones, Andrew R
    University of Liverpool, UK.
    Pirmohamed, Munir
    University of Liverpool, UK.
    In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers2012Ingår i: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 4, nr 6, artikel-id 51Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Drug-induced liver injury (DILI) is one of the most common adverse reactions leading to product withdrawal post-marketing. Recently, genome-wide association studies have identified a number of human leukocyte antigen (HLA) alleles associated with DILI; however, the cellular and chemical mechanisms are not fully understood.

    METHODS: To study these mechanisms, we established an HLA-typed cell archive from 400 healthy volunteers. In addition, we utilized HLA genotype data from more than four million individuals from publicly accessible repositories such as the Allele Frequency Net Database, Major Histocompatibility Complex Database and Immune Epitope Database to study the HLA alleles associated with DILI. We utilized novel in silico strategies to examine HLA haplotype relationships among the alleles associated with DILI by using bioinformatics tools such as NetMHCpan, PyPop, GraphViz, PHYLIP and TreeView.

    RESULTS: We demonstrated that many of the alleles that have been associated with liver injury induced by structurally diverse drugs (flucloxacillin, co-amoxiclav, ximelagatran, lapatinib, lumiracoxib) reside on common HLA haplotypes, which were present in populations of diverse ethnicity.

    CONCLUSIONS: Our bioinformatic analysis indicates that there may be a connection between the different HLA alleles associated with DILI caused by therapeutically and structurally different drugs, possibly through peptide binding of one of the HLA alleles that defines the causal haplotype. Further functional work, together with next-generation sequencing techniques, will be needed to define the causal alleles associated with DILI.

  • 356.
    Alfonseca, M Angeles
    et al.
    N Dakota State University.
    Auscher, Pascal
    University Paris 11.
    Axelsson Rosén, Andreas
    Linköpings universitet, Matematiska institutionen, Tillämpad matematik. Linköpings universitet, Tekniska högskolan.
    Hofmann, Steve
    University of Missouri.
    Kim, Seick
    Yonsei University.
    Analyticity of layer potentials and L-2 solvability of boundary value problems for divergence form elliptic equations with complex L-infinity coefficients2011Ingår i: Advances in Mathematics, ISSN 0001-8708, E-ISSN 1090-2082, Vol. 226, nr 5, s. 4533-4606Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We consider divergence form elliptic operators of the form L = -div A (x)del, defined in Rn+1 = {(x, t) is an element of R-n x R}, n andgt;= 2, where the L-infinity coefficient matrix A is (n + 1) x (n + 1), uniformly elliptic, complex and t-independent. We show that for such operators, boundedness and invertibility of the corresponding layer potential operators on L-2 (R-n) = L-2(partial derivative R-+(n+1)) is stable under complex, L-infinity perturbations of the coefficient matrix. Using a variant of the Tb Theorem, we also prove that the layer potentials are bounded and invertible on L-2(R-n) whenever A (x) is real and symmetric (and thus, by our stability result, also when A is complex, parallel to A - A(0)parallel to(infinity) is small enough and A(0) is real, symmetric, L-infinity and elliptic). In particular, we establish solvability of the Dirichlet and Neumann (and Regularity) problems, with L-2 (resp. (L) over dot(1)(2)) data, for small complex perturbations of a real symmetric matrix. Previously, L-2 solvability results for complex (or even real but non-symmetric) coefficients were known to hold only for perturbations of constant matrices (and then only for the Dirichlet problem), or in the special case that the coefficients A (j,n+1)= 0 = A(n+1,j), 1 andlt;= j andlt;= n, which corresponds to the Kato square root problem.

  • 357.
    Alfredson, J.
    FOI, Swedish Defence Research Agency, P.O. Box 1165, SE-581 11 Linkoping, Sweden.
    Individual differences in visual behaviour in simulated flight2002Ingår i: Proceedings of SPIE, the International Society for Optical Engineering, ISSN 0277-786X, E-ISSN 1996-756X, Vol. 4662, s. 494-502Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    Flying an aircraft is highly visually demanding. It is very important to map pilot visual behaviour, both for the purpose of evaluating the cockpit interface and to effectively integrate it with future adaptive interfaces and decision support systems. Pilots' visual behaviour was studied in two experiments. In the first experiment commercial aviation pilots were flying a commercial aviation scenario and eye point of gaze, and eye blinks were collected. In the second experiment military pilots were flying an air-to-air combat scenario and the visual behaviour was video recorded. In both of the experiments the results show individual differences in the pilots' visual behaviour. In the second experiment two different categories of eye blinks were found that might help explain the individual differences in visual behaviour. One category can be related to the systematic eye blinks found to occur when the eye point of gaze was changed between head-up/head-down and head-down/head-up. The other category could be related to other reasons, such as, mental workload or visual demands.

  • 358.
    Alfredson, Jens
    Linköpings universitet, Institutionen för datavetenskap. Linköpings universitet, Tekniska fakulteten. Saab Aeronaut, S-58247 Linkoping, Sweden.
    Adaptive Interaction Criteria for Future Remotely Piloted Aircraft2017Ingår i: ADVANCES IN HUMAN FACTORS IN ROBOTS AND UNMANNED SYSTEMS, SPRINGER INT PUBLISHING AG , 2017, Vol. 499, s. 281-289Konferensbidrag (Refereegranskat)
    Abstract [en]

    There are technical trends and operational needs within the aviation domain towards adaptive behavior. This study focus on adaptive interaction criteria for future remotely piloted aircraft. Criteria that could be used to guide and evaluate design as well as to create a model for adaptive interaction used by autonomous functions and decision support. A scenario and guidelines from the literature, used as example criteria, was presented in a questionnaire to participants from academia/researchers, end users, and aircraft development engineers. Several guidelines had a wide acceptance among the participants, but there was also aspects missing for the application of supporting adaptive interaction for remotely piloted aircraft. The various groups of participants contributed by different aspects supports the idea of having various stakeholders contributing with complementary views. Aspects that the participants found missing includes, predictability, aviation domain specifics, risk analysis, complexity and how people perceive autonomy and attribute intentions.

  • 359.
    Alfredson, Jens
    et al.
    SAAB, Linköping, Sweden.
    Johansson, Björn
    Linköpings universitet, Institutionen för datavetenskap, Interaktiva och kognitiva system. Linköpings universitet, Filosofiska fakulteten.
    Gonzaga Trabasso, Luis
    Aeronautics Institute of Technology, Brazil.
    Schminder, Jörg
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    Granlund, Rego
    Research Institutes of Sweden SICS East, Linköping, Sweden.
    Gårdhagen, Roland
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Mekanisk värmeteori och strömningslära. Linköpings universitet, Tekniska fakulteten.
    DESIGN OF A DISTRIBUTED HUMAN FACTORS LABORATORY FOR FUTURE AIRSYSTEMS2018Ingår i: ICAS congress proceeding, International Council of the Aeronautical Sciences , 2018, artikel-id ICAS2018_0305Konferensbidrag (Övrigt vetenskapligt)
    Abstract [en]

    This paper presents a rationale for structuring a distributed human factors laboratory for future air systems. The distributed herein refers to two aspects: content and geographic. As for content, the laboratory is structured in two levels, namely, individual, and team. As for geographic, the laboratory infrastructure is distributed in three physically separate facilities, namely, Department of Computer and Information Science (IDA) and Department of Management and Engineering (IEI) from Linköping University – Sweden and the Competence Center in Manufacturing from the Aeronautics Institute of Technology (ITA) – Brazil.

  • 360.
    Alfredsson, Erik
    Linköpings universitet, Institutionen för systemteknik.
    Design and implementation of a hardware unit for complex division2005Självständigt arbete på grundnivå (yrkesexamen), 20 poäng / 30 hpStudentuppsats
    Abstract [en]

    The purpose of the thesis was to investigate and evaluate existing algorithms for division of complex numbers. The investigation should include implementation of a few suitable algorithms in VHDL. The main application for the divider is compensation for fading in a baseband processor.

    Since not much public research is done within the area of complex division in hardware, a divider based on real valued division was designed. The design only implements inversion of complex numbers instead of complete division because it is simpler and the application does not need full division, thus the required chip size is reduced.

    An examination of the different kinds of algorithms that exists for real valued division was done and two of the methods were found suitable for implementation, digit recurrence and functional iteration. From each of the two classes of algorithms one algorithm was chosen and implemented in VHDL. Two different versions of the inverter were designed for each method, one with full throughput and one with half throughput. The implementations show very similar results in terms of speed, size and performance. For most cases however, the digit recurrence implementation has a slight advantage.

  • 361.
    Alfredsson, Jonas
    Linköpings universitet, Institutionen för systemteknik.
    Portning av ett plugin till 3d-modelleringsprogram2008Självständigt arbete på avancerad nivå (yrkesexamen), 20 poäng / 30 hpStudentuppsats
    Abstract [sv]

    Rapporten beskriver arbetet och resultatet funnet vid jämförelser mellan tre olika 3d modelleringsprogram. Programmen är 3ds Max, Maya och Cinema 4D. Jämförelserna fokuserar på de möjligheter/friheter dessa programs gränssnitt erbjuder sina plugins. Utgångspunkt i jämförelserna är ett animerings verktyg utvecklat som ett plugin till dessa modelleringsporgram. Detta plugins krav på systemet det laddas i har analyserats och utifrån dessa analyser har en mall skapats för att vid vidare portningar till andra modelleringsprogram på ett tidigt stadium kunna avgöra om det är möjligt eller inte. Denna mall finns med som en bilaga till rapporten. Pluginet som nämns ovan är i sin tur också det ett system med plugin arkitektur och beskrivs på en övergripande nivå i rapporten.

  • 362.
    Alfredsson, Maria
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Kemi.
    Synthesis and Characterization of Acrylfentanyl Metabolites2017Självständigt arbete på grundnivå (kandidatexamen), 10,5 poäng / 16 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Acrylfentanyl is a synthetic opioid that has been widely used in the last year. To help in the fight against synthetic drugs two potential metabolites of acrylfentanyl, one monohydroxy and one dihydroxy were synthesized. These metabolites will hopefully later be implemented in the analytical methods for metabolites of acrylfentanyl in urine by the Swedish National Board of Forensic Medicine.

    To have metabolites for analysis are very important as they are the main target in drug testing.

    The method used to synthesize the metabolites is a five-step synthesis with an additional 6th step for the dihydroxy metabolite. The methods used in the synthesis includes protection of amine with tert-butyloxycarbonyl, reductive amination with sodium triaceto boronhydride, alkylation and demethylation with boron tribromide. The methods used produced good results with high yields in nearly all steps.

  • 363.
    Alfredsson, Maria
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Kemi.
    Synthesis and characterization of novel thiophene based tetramers for potential detection of protein aggregates2019Självständigt arbete på avancerad nivå (masterexamen), 40 poäng / 60 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Alzheimer’s disease is a big problem in the elderly population. An important tool in gaining insight in this disease are staining studies using different probes. Conjugated oligothiophenes have shown promising properties as probes and in this thesis new potential probes have been made.

    Three new tetrameric probes have been synthesized, consisting of three thiophene units and one aromatic heterocycle moiety. The aromatic heterocycles used were BTD, pyridine and indole. The synthesis method involved Suzuki cross coupling, bromination with NBS and iridium catalyst borylation. The BTD and pyridine containing probes were tested in staining experiments and the pyridine probe showed promising results.

  • 364. Alfredsson, Maria
    et al.
    Ojamae, Lars
    Hermansson, Kersti
    Uppsala universitet, Strukturkemi.
    A comparison of Hartree-Fock, MP2, and DFT results for the HCN dimer and crystal1996Ingår i: INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Vol. 60, nr 3, s. 767-777Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A number of hydrogen-bond related quantities-geometries, interaction energies, dipole moments, dipole moment derivatives, and harmonic vibrational frequencies-were calculated at the Hartree-Fock, MP2, and different DFT levels for the HCN dimer and the pe

  • 365.
    Algergawy, Alsayed
    et al.
    Friedrich Schiller University Jena, Germany.
    Cheatham, Michelle
    Wright State University, USA.
    Faria, Daniel
    Instituto Gulbenkian de Ciencia, Lisbon, Portugal.
    Ferrara, Alfio
    Universita degli studi di Milano, Italy.
    Fundulaki, Irina
    FORTH, Greece.
    Harrow, Ian
    Pistoia Alliance Inc., USA.
    Hertling, Sven
    University of Mannheim, Germany.
    Jimenez-Ruiz, Ernesto
    Alan Turing Institute, London, UK; University of Oslo, Norway.
    Karam, Naouel
    Fraunhofer FOKUS, Berlin, Germany.
    Khiat, Abderrahman
    Freie Universität Berlin, Germany.
    Lambrix, Patrick
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska högskolan.
    Li, Huanyu
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska fakulteten.
    Montanelli, Stefano
    Universita degli studi di Milano, Italy.
    Paulheim, Heiko
    University of Mannheim, Germany.
    Pesquita, Catia
    Universidade de Lisboa, Portugal.
    Saveta, Tzanina
    FORTH, Greece.
    Schmidt, Daniela
    Pontifical Catholic University of Rio Grande do Sul, Brazil.
    Shvaiko, Pavel
    Trentino Digitale SpA, Trento, Italy.
    Splendiani, Andrea
    Pistoia Alliance Inc., USA.
    Thiéblin, Elodie
    IRIT & Université Toulouse II, Toulouse, France.
    Trojahn, Cassia
    IRIT & Université Toulouse II, Toulouse, France.
    Vatascinova, Jana
    University of Economics, Prague, Czech Republic.
    Zamazal, Ondrej
    University of Economics, Prague, Czech Republic.
    Zhou, Lu
    Wright State University, USA.
    Results of the Ontology Alignment Evaluation Initiative 20182018Ingår i: Proceedings of the 13th International Workshop on Ontology Matching: co-located with the 17th International Semantic Web Conference (ISWC 2018) / [ed] Pavel Shvaiko, Jérôme Euzenat, Ernesto Jiménez-Ruiz, Michelle Cheatham, Oktie Hassanzadeh, Aachen, Germany: CEUR Workshop Proceedings , 2018, Vol. 2288, s. 76-116Konferensbidrag (Refereegranskat)
    Abstract [en]

    The Ontology Alignment Evaluation Initiative (OAEI) aims at comparing ontology matching systems on precisely defined test cases. These test cases can be based on ontologies of different levels of complexity (from simple thesauri to expressive OWL ontologies) and use different evaluation modalities (e.g., blind evaluation, open evaluation, or consensus). The OAEI 2018 campaign offered 12 tracks with 23 test cases, and was attended by 19 participants. This paper is an overall presentation of that campaign.

  • 366.
    Al-Hilli, Safaa
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
    Willander , Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
    Membrane potential measurements across a human fat cell using ZnO nanorods2009Ingår i: NANOTECHNOLOGY, ISSN 0957-4484 , Vol. 20, nr 17, s. 175103-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A ZnO nanorod probe was employed to determine the resting membrane potential of a human fat cell. The distribution of protons associated with the cell versus the extracellular distribution is proportional to changes in membrane potential. The membrane potential determines the concentration gradient of the protons with dominant permeability according to the Nernst equation. A ZnO nanorod probe was successfully used to find the resting membrane potential for a human fat cell: 34 +/- 2.6 mV.

  • 367.
    Al-Hussaini, M
    et al.
    Kuwait Univ, Dept Pharmacol & Toxicol, Fac Med, Safat 13060, Kuwait.
    Oriowo, MA
    Kuwait Univ, Dept Pharmacol & Toxicol, Fac Med, Safat 13060, Kuwait.
    Philip, E
    Kuwait Univ, Dept Pharmacol & Toxicol, Fac Med, Safat 13060, Kuwait.
    Thulesius, O
    Kuwait Univ, Dept Pharmacol & Toxicol, Fac Med, Safat 13060, Kuwait.
    Prokinetic effect of duodenal extract on ovine gallbladders2000Ingår i: Medical principles and practice, ISSN 1011-7571, E-ISSN 1423-0151, Vol. 9, nr 1, s. 74-80Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: It is known that the macrolide antibiotic erythromycin stimulates gastrointestinal and gallbladder motility by an as yet unidentified mechanism. It was the objective of this study to investigate the mechanism of the gallbladder motility-stimulating effect of erythromycin. Methods: In our experiments we used strips of sheep gallbladders measuring isometric tension in organ baths. Since erythromycin itself did not induce contraction we examined the prokinetic effects of sheep duodenal extract, incubated with (DEX) or without (blank) erythromycin (10(-5) M). Results: Both DEX and blank elicited gallbladder contraction associated with heat-stable, water-soluble but not with lipid-soluble duodenal prokinetic factor. The factor is unrelated to motilin or cholecystokinin and is only partially (<20%) blocked by atropine (10(-6) M) and not affected by the pretreatment with dexamethasone or somatostatin. Conclusion: It was concluded that erythromycin indirectly stimulates contraction of ovine gallbladders through the endogenous release of a duodenal prokinetic factor. Copyright (C) 2000 S. Karger AG, Basel.

  • 368.
    Ali, A.
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan. Bahauddin Zakriya University, Multan, Pakistan.
    AlSalhi, M. S.
    King Saud University, Riyadh, Saudi Arabia and Bahauddin Zakriya University, Multan, Pakistan.
    Atif, M.
    King Saud University, Riyadh, Saudi Arabia.
    Ansari, Anees A.
    King Saud University, Riyadh, Saudi Arabia.
    Israr, Muhammad Qadir
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
    Sadaf, J. R.
    Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
    Ahmed, E.
    Bahauddin Zakriya University, Multan, Pakistan.
    Nur, Omer
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    Willander, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    Potentiometric urea biosensor utilizing nanobiocomposite of chitosan-iron oxide magnetic nanoparticles2013Ingår i: 21st International Laser Physics Workshop 23–27 July 2012, Calgary, Canada, Institute of Physics (IOP), 2013, Vol. 414, artikel-id 012024Konferensbidrag (Refereegranskat)
    Abstract [en]

    The iron oxide (Fe3O4) magnetic nanoparticles have been fabricated through a simple, cheap and reproducible approach. Scanning electron microscope, x-rays powder diffraction of the fabricated nanoparticles. Furthermore, the fabrication of potentiometric urea biosensor is carried out through drop casting the initially prepared isopropanol and chitosan solution, containing Fe3O4 nanoparticles, on the glass fiber filter with a diameter of 2 cm and a copper wire (of thickness −500 μm) has been utilized to extract the voltage signal from the functionalized nanoparticles. The functionalization of surface of the Fe3O4 nanoparticles is obtained by the electrostatically immobilization of urease onto the nanobiocomposite of the chitosan- Fe3O4 in order to enhance the sensitivity, specificity, stability and reusability of urea biosensor. Electrochemical detection procedure has been adopted to measure the potentiometric response over the wide logarithmic concentration range of the 0.1 mM to 80 mM. The Fe3O4 nanoparticles based urea biosensor depicts good sensitivity with ~42 mV per decade at room temperature. Durability of the biosensor could be considerably enhanced by applying a thin layer of the nafion. In addition, the reasonably stable output response of the biosensor has been found to be around 12 sec.

  • 369.
    Ali Abbasi, Mazhar
    et al.
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    Hussain Ibupoto, Zafar
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    Liu, Xianjie
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Ytors Fysik och Kemi. Linköpings universitet, Tekniska högskolan.
    Nur, Omer
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    Willander, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska högskolan.
    The determination of valence band offset and the current transport properties of the p-NiO/n-ZnO heterojunction2013Manuskript (preprint) (Övrigt vetenskapligt)
    Abstract [en]

    The electron transport in the electronic devices has significant influence on the device performance, thus current transport properties determination is highly demanded for a particular device. Herein, we report the facile hydrothermal growth method based fabrication of p-NiO/n-ZnO heterojunction. The material characterization was performed by scanning electron microscopy, X-ray diffraction, transmission electron microscopy and X-ray photo electron spectroscopy. These techniques provided the good crystal quality, pure phase of p-NiO and n-ZnO nanostructures respectively. The measured valance band offset of composite nanostructure is 2.25 eV and conduction band offset was found to be 2.58 eV. The current transport properties of the fabricated p-n junction are governed by three different I-V regions. The impedance spectroscopy was used for the determination of the role of grain boundaries at the interface.

  • 370.
    Ali, Akhtar
    et al.
    Linköpings universitet, Tekniska högskolan.
    Dastgeer, Usman
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    Kessler, Christoph
    Linköpings universitet, Institutionen för datavetenskap, Programvara och system. Linköpings universitet, Tekniska högskolan.
    OpenCL for programming shared memory multicore CPUs2012Ingår i: Proceedings of the 5th Workshop on MULTIPROG2012 / [ed] E. Ayguade, B. Gaster, L. Howes, P. Stenström, O. Unsal, HiPEAC Network of Excellence , 2012Konferensbidrag (Refereegranskat)
    Abstract [en]

    Shared memory multicore processor technology is pervasive in mainstream computing. This new architecture challenges programmers to write code that scales over these many cores to exploit the full computational power of these machines. OpenMP and Intel Threading Building Blocks (TBB) are two of the popular frameworks used to program these architectures. Recently, OpenCL has been defined as a standard by Khronos group which focuses on programming a possibly heterogeneous set of processors with many cores such as CPU cores, GPUs, DSP processors. In this work, we evaluate the effectiveness of OpenCL for programming multicore CPUs in a comparative case study with OpenMP and Intel TBB for five benchmark applications: matrix multiply, LU decomposition,2D image convolution, Pi value approximation and image histogram generation. The evaluation includes the effect of compiler optimizations for different frameworks, OpenCL performance on different vendors’ platformsand the performance gap between CPU-specific and GPU-specific OpenCL algorithms for execution on a modern GPU. Furthermore, a brief usability evaluation of the three frameworks is also presented.

  • 371.
    Ali, Amjad
    et al.
    COMSATS Univ Islamabad, Pakistan; Univ Okara, Pakistan.
    Raza, Rizwan
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Halvledarmaterial. Linköpings universitet, Tekniska fakulteten. COMSATS Univ Islamabad, Pakistan.
    Shakir, Muhammad Imran
    King Saud Univ, Saudi Arabia; Univ Calif Los Angeles, CA 90095 USA.
    Rafique, Asia
    COMSATS Univ Islamabad, Pakistan.
    Alvi, Farah
    COMSATS Univ Islamabad, Pakistan.
    Ullah, Muhammad Kaleem
    COMSATS Univ Islamabad, Pakistan.
    Hamid, Abdul
    Univ Okara, Pakistan.
    Kim, Jung-Sik
    Loughborough Univ, England.
    Promising electrochemical study of titanate based anodes in direct carbon fuel cell using walnut and almond shells biochar fuel (vol 434, 126679, 2019)2019Ingår i: Journal of Power Sources, ISSN 0378-7753, E-ISSN 1873-2755, Vol. 438, artikel-id 226932Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    n/a

  • 372.
    Ali Arslan, Mehmet
    et al.
    Lund University, Sweden.
    Gruian, Flavius
    Lund University, Sweden.
    Kuchcinski, Krzysztof
    Lund University, Sweden.
    Karlsson, Andreas
    Linköpings universitet, Institutionen för systemteknik. Linköpings universitet, Tekniska fakulteten.
    Code Generation for a SIMD Architecture with Custom Memory Organisation2016Ingår i: PROCEEDINGS OF THE 2016 CONFERENCE ON DESIGN AND ARCHITECTURES FOR SIGNAL and IMAGE PROCESSING, IEEE , 2016, s. 90-97Konferensbidrag (Refereegranskat)
    Abstract [en]

    Todays multimedia and DSP applications impose requirements on performance and power consumption that only custom processor architectures with SIMD capabilities can satisfy. However, the specific features of such architectures, including vector operations and high-bandwidth complex memory organization, make them notoriously complicated and time consuming to program. In this paper we present an automated code generation approach that dramatically reduces the effort of programming such architectures, by carrying out instruction scheduling and memory allocation based on a constraint programming formulation. Furthermore, the quality of the generated code is close to that of hand-written code by an experienced programmer with knowledge of the architecture. We demonstrate the viability of our approach on an existing custom heterogeneous DSP architecture, by compiling and running a number of typical DSP kernels, and comparing the results to hand-optimized code.

  • 373.
    Ali, Asif
    et al.
    Linköpings universitet, Institutionen för datavetenskap.
    Ramzan, Faheem
    Linköpings universitet, Institutionen för datavetenskap.
    Analysis and Monitoring of Team Collaboration in Emergency Response Training supported by a Web Based Information Management System2009Självständigt arbete på avancerad nivå (masterexamen), 30 poäng / 45 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Our objective in this thesis work is to analyze and manage the log files which are generated after a number of experiments series on different groups using C3Fire simulation environment. It includes analyzing and extracting information from log files, and then maintaining this information in a database. This should be presented with a web interface through ICEfaces Ajax framework for Java. Log Files are generated after a number of experiments series on the different groups. All sequences and information related to task performed by team in group is organized in session log files. The work is divided into different steps; first step is to analyze and extract data from log files, and properly arrange it in several different tables in a database, for this MySQL database is used to store the information. The web interface of log file management system is implemented using ICEfaces Ajax framework, and is based on the statistics of log files generated from the C3Fire environment.  User would be able to add/remove the log files, also can view or edit the details of each session log file in database through web interface. Different events can be generated, and logged for the session information.

    C3Fire is an environment that supports training and research in team collaboration. The environment is mainly used in command, control and communication research, and in training of team decision making. Many humanitarian relief operations are doing their work without having any practice. When some disaster events occur, they cannot perform their jobs effectively. Effective and efficient relief operation is the need of humanity; even that’s not enough to move teams to the disaster place at right time; communication and co-ordination among the team members is the big factor to make effective and well-organized work. C3Fire is a simulation system which provides the training for team members to handle such type of disaster events, and makes the work more proficient at that time by doing effective coordination.

  • 374.
    Ali, Gulzar
    et al.
    University of Sindh, Pakistan.
    Tahira, Aneela
    Luleå University of Technology, Sweden.
    Begum Mallah, Arfana
    University of Sindh, Pakistan.
    Ahmed Mallah, Sarfraz
    University of Sindh, Pakistan.
    Ibupoto, Akila
    Shah Abdul Latif University, Pakistan.
    Ahmed Khand, Aftab
    Tsinghua University, Peoples R China.
    Baradi, Waryani
    University of Sindh, Pakistan.
    Willander, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Yu, Cong
    Chinese Academic Science, Peoples R China.
    Hussain Ibupoto, Zafar
    University of Sindh, Pakistan; Chinese Academic Science, Peoples R China.
    Functional CuO Microstructures for Glucose Sensing2018Ingår i: Journal of Electronic Materials, ISSN 0361-5235, E-ISSN 1543-186X, Vol. 47, nr 2, s. 1519-1525Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    CuO microstructures are produced in the presence of water-soluble amino acids by hydrothermal method. The used amino acids include isoleucine, alpha alanine, and arginine as a soft template and are used for tuning the morphology of CuO nanostructures. The crystalline and morphological investigations were carried out by x-ray diffraction (XRD) and scanning electron microscopy techniques. The XRD study has shown that CuO material obtained in the presence of different amino acids is of high purity and all have the same crystal phase. The CuO microstructures prepared in the presence of arginine were used for the development of sensitive and selective glucose biosensor. The linear range for the glucose detection are from 0.001 mM to 30 mM and limit of detection was found to be 0.0005 mM. The sensitivity was estimated around 77 mV/decade. The developed biosensor is highly selective, sensitive, stable and reproducible. The glucose biosensor was used for the determination of real human blood samples and the obtained results are satisfactory. The CuO material is functional therefore can be capitalized in wide range of applications such as lithium ion batteries, all oxide solar cells and supercapacitors.

  • 375.
    Ali Kamyabi, Mohammad
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska fakulteten. Zanjan University, Iran.
    Hajari, Nasim
    Zanjan University, Iran.
    Turner, Anthony
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska fakulteten.
    Tiwari, Ashutosh
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska fakulteten.
    Correction: A high-performance glucose biosensor using covalently immobilised glucose oxidase on a poly(2,6-diaminopyridine)/carbon nanotube electrode (vol 116, pg 801, 2013)2016Ingår i: Talanta: The International Journal of Pure and Applied Analytical Chemistry, ISSN 0039-9140, E-ISSN 1873-3573, Vol. 153, s. 414-415Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A highly-sensitive glucose biosensor amenable to ultraminiaturisation was fabricated by immobilization of glucose oxidase (wGOX), onto a poly(2,6-diaminopyridine)/multi-walled carbon nanotube/glassy carbon electrode (poly(2,6-DP)/MWCNT/GCE). Cyclic voltammetry was used for both the electrochemical synthesis of poly-(2,6-DP) on the surface of a MWCNT-modified GC electrode, and characterization of the polymers deposited on the GC electrode. The synergistic effect of the high active surface area of both the conducting-polymer, i.e., poly-(2,6-DP) and MWCNT gave rise to a remarkable improvement in the electrocatalytic properties of the biosensor. The transfer coefficient (alpha), heterogeneous electron transfer rate constant and Michaelis-Menten constant were calculated to be 0.6, 4 s-1 and 0.22 mM at pH 7.4, respectively. The GOx/poly(2,6-DP)/MWCNT/GC bioelectrode exhibited two linear responses to glucose in the concentration ranging from 0.42 mu M to 8.0 mM with a correlation coefficient of 0.95, sensitivity of 52.0 mu AmM-1 cm-2, repeatability of 1.6% and long-term stability, which could make it a promising bioelectrode for precise detection of glucose in the biological samples. (C) 2016 Elsevier B.V. All rights reserved.

  • 376.
    Ali, M.
    et al.
    Helsinki University of Technology (TKK), Micronova, Department of Micro and Nanosciences, P.O. Box 3500, FIN-02015 TKK, Finland.
    Svensk, Olle
    Helsinki University of Technology (TKK), Micronova, Department of Micro and Nanosciences, P.O. Box 3500, FIN-02015 TKK, Finland.
    Zhen, Z.
    Helsinki University of Technology (TKK), Micronova, Department of Micro and Nanosciences, P.O. Box 3500, FIN-02015 TKK, Finland.
    Suihkonen, S.
    Helsinki University of Technology (TKK), Micronova, Department of Micro and Nanosciences, P.O. Box 3500, FIN-02015 TKK, Finland.
    Törmä, P.T.
    Helsinki University of Technology (TKK), Micronova, Department of Micro and Nanosciences, P.O. Box 3500, FIN-02015 TKK, Finland.
    Lipsanen, H.
    Helsinki University of Technology (TKK), Micronova, Department of Micro and Nanosciences, P.O. Box 3500, FIN-02015 TKK, Finland.
    Sopanen, M.
    Helsinki University of Technology (TKK), Micronova, Department of Micro and Nanosciences, P.O. Box 3500, FIN-02015 TKK, Finland.
    Hjort, Klas
    Department of Engineering Sciences, Uppsala University, P.O. Box 534, SE-75121 Uppsala, Sweden.
    Jensen, Jens
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska högskolan.
    Reduced photoluminescence from InGaN/GaN multiple quantum well structures following 40 MeV iodine ion irradiation2009Ingår i: Physica. B, Condensed matter, ISSN 0921-4526, E-ISSN 1873-2135, ISSN 0921-4526, Vol. 404, nr 23-24, s. 4925-4928Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The effects following ion irradiation of GaN-based devices are still limited. Here we present data on the photoluminescence (PL) emitted from InGaN/GaN multiple quantum well (MQW) structures, which have been exposed to 40 MeV I ion irradiation. The PL is reduced as a function of applied ion fluence, with essentially no PL signal left above 1011 ions/cm2. It is observed that even the ion fluences in the 109 ions/cm2 range have a pronounced effect on the photoluminescence properties of the MQW structures. This may have consequences concerning application of InGaN/GaN MQW’s in radiation-rich environments, in addition to defect build-up during ion beam analysis.

  • 377.
    Ali Malik, Muhammad
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik. Linköpings universitet, Tekniska fakulteten.
    Gatto, Emanuela
    University Roma Tor Vergata.
    Macken, Stephen
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik. Linköpings universitet, Tekniska fakulteten.
    DiNatale, Corrado
    University Roma Tor Vergata.
    Paolesse, Roberto
    University Roma Tor Vergata.
    DAmico, Arnaldo
    University Roma Tor Vergata.
    Lundström, Ingemar
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik. Linköpings universitet, Tekniska högskolan.
    Filippini, Daniel
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik. Linköpings universitet, Tekniska högskolan.
    Imaging fingerprinting of excitation emission matrices2009Ingår i: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 635, nr 2, s. 196-201Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The spectral fingerprinting of the excitation emission matrix (EEM) of fluorescent substances is demonstrated using polychromatic light sources and tri-chromatic image detectors. A model of the measured fingerprints explaining their features and classification performance, based on the polychromatic excitation of the indicators is proposed.

    Substantial amount of spectral information is retained in the fingerprints as corroborated by multivariate analysis and experimental conditions that favor such situation are identified.

    In average, for five different substances, the model shows a fitting goodness measured by the Pearsons r coefficient and the root mean square deviation of 0.8541 and 0.0247 respectively, while principal component classification patterns satisfactorily compare with the EEM spectroscopy classification and respectively explain 96% and 93% of the information in the fist two principal components.

    The measurements can be performed using regular computer screens as illumination and web cameras as detectors, which constitute ubiquitous and affordable platforms compatible with distributed evaluations, in contrast to regular instrumentation for EEM measurements.

  • 378.
    Ali, Sharafat
    et al.
    Linnaeus University, Sweden; Corning Inc, NY 14831 USA.
    Paul, Biplab
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Magnusson, Roger
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Broitman, Esteban
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska fakulteten.
    Jonson, Bo
    Linnaeus University, Sweden.
    Eklund, Per
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Birch, Jens
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Synthesis and characterization of the mechanical and optical properties of Ca-Si-O-N thin films deposited by RF magnetron sputtering2017Ingår i: Surface & Coatings Technology, ISSN 0257-8972, E-ISSN 1879-3347, Vol. 315, s. 88-94Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Ca-Si-O-N thin films were deposited on commercial soda-lime silicate float glass, silica wafers and sapphire substrates by RF magnetron co-sputtering from Ca and Si targets in an Ar/N-2/O-2 gas mixture. Chemical composition, surface morphology, hardness, reduced elastic modulus and optical properties of the films were investigated using X-ray photoelectron spectroscopy, scanning electron microscopy, nanoindentation, and spectroscopic ellipsometry. It was found that the composition of the films can be controlled by the Ca target power, predominantly, and by the reactive gas flow. Thin films in the Ca-Si-O-N system are composed of N and Ca contents up to 31 eq. % and 60 eq. %, respectively. The films thickness ranges from 600 to 3000 nm and increases with increasing Ca target power. The films surface roughness varied between 2 and 12 nm, and approximately decreases with increasing power of Ca target. The hardness (4-12 GPa) and reduced elastic modulus (65-145 GPa) of the films increase and decrease with the N and Ca contents respectively. The refractive index (1.56-1.82) is primarily dictated by the N content. The properties are compared with findings for bulk glasses in the Ca-Si-(Al)-O-N systems, and it is concluded that Ca-Si-O-N thin films have higher values of hardness, elastic modulus and refractive index than bulk glasses of similar composition. (C) 2017 Elsevier B.V. All rights reserved.

  • 379.
    Ali, Sharafat
    et al.
    Linnaeus Univ, Sweden.
    Paul, Biplab
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Magnusson, Roger
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Ekström, Erik
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Pallier, Camille
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten. RISE IVF, S-58188 Linkoping, Sweden.
    Jonson, Bo
    Linnaeus Univ, Sweden.
    Eklund, Per
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Birch, Jens
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Optical and mechanical properties of amorphous Mg-Si-O-N thin films deposited by reactive magnetron sputtering2019Ingår i: Surface & Coatings Technology, ISSN 0257-8972, E-ISSN 1879-3347, Vol. 372, s. 9-15Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this work, amorphous thin films in Mg-Si-O-N system typically containing amp;gt; 15 at.% Mg and 35 at.% N were prepared in order to investigate especially the dependence of optical and mechanical properties on Mg composition. Reactive RF magnetron co-sputtering from magnesium and silicon targets were used for the deposition of Mg-Si-O-N thin films. Films were deposited on float glass, silica wafers and sapphire substrates in an Ar, N-2 and O-2 gas mixture. X-ray photoelectron spectroscopy, atomic force microscopy, scanning electron microscopy, spectroscopic ellipsometry, and nanoindentation were employed to characterize the composition, surface morphology, and properties of the films. The films consist of N and Mg contents up to 40 at.% and 28 at.%, respectively and have good adhesion to substrates and are chemically inert. The thickness and roughness of the films increased with increasing content of Mg. Both hardness (16-21 GPa) and reduced elastic modulus (120-176 GPa) are strongly correlated with the amount of Mg content. The refractive index up to 2.01 and extinction coefficient up to 0.18 were found to increase with Mg content. The optical band gap (3.1-4.3) decreases with increasing the Mg content. Thin film deposited at substrate temperature of 100 degrees C shows a lower value of hardness (10 GPa), refractive index (1.75), and higher values of reduced elastic modulus (124 GPa) as compared to the thin film deposited at 310 degrees C and 510 degrees C respectively, under identical synthesis parameters.

  • 380.
    Ali, Sharafat
    et al.
    Linnaeus University, Sweden.
    Paul, Biplab
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Magnusson, Roger
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad optik. Linköpings universitet, Tekniska fakulteten.
    Greczynski, Grzegorz
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Broitman, Esteban
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska fakulteten.
    Jonson, Bo
    Linnaeus University, Sweden.
    Eklund, Per
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Birch, Jens
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Tunnfilmsfysik. Linköpings universitet, Tekniska fakulteten.
    Novel transparent Mg-Si-O-N thin films with high hardness and refractive index2016Ingår i: Vacuum, ISSN 0042-207X, E-ISSN 1879-2715, Vol. 131Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    There is an increasing demand for glass materials with better mechanical and optical properties for display and electronic applications. This paper describes the deposition of novel thin films of Mg-circle divide-Si-O-N onto float glass substrates. Amorphous thin films in the Mg-Si-O-N system with high nitrogen and magnesium contents were deposited by reactive RF magnetron co-sputtering from Mg and Si targets in Ar/N-2/O-2 gas mixtures. The thin films studied span an unprecedented range of compositions up to 45 at% Mg and 80 at% N out of cations and anions respectively. Thin films in the Mg-Si-O-N system were found to be homogeneous and transparent in the visible region. Mechanical properties like hardness (H) and reduced elastic modulus (Er) show high values, up to 21 GPa and 166 GPa respectively. The refractive index (1.87-2.00) increases with increasing magnesium and nitrogen contents. (C) 2016 Elsevier Ltd. All rights reserved.

  • 381.
    Ali Soomro, Razium
    et al.
    University of Sindh, Pakistan.
    Hallam, Keith Richard
    University of Bristol, UK.
    Hussain Ibupoto, Zafar
    University of Sindh, Pakistan.
    Tahira, Aneela
    University of Sindh, Pakistan.
    Tufail Hussain Sherazi, Syed
    University of Sindh, Pakistan.
    Juddin, Siraj
    University of Sindh, Pakistan.
    Jawaid, Sana
    University of Sindh, Pakistan.
    Willander, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Glutaric Acid Assisted Fabrication of CuO Nanostructures and their Application in Development of Highly Sensitive Electrochemical Sensor System for Carbamates2016Ingår i: Electroanalysis, ISSN 1040-0397, E-ISSN 1521-4109, Vol. 28, nr 7, s. 1634-1640Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This work describes the fabrication of unique arrow head shaped CuO nanostructures using simple hydrothermal treatment method. The highly attractive features were obtained by the application of glutaric acid utilised simultaneous as template and functionalising agent. The functionalised nanostructures were known to possess excellent potential towards the electro-catalytic oxidation of carbofuran pesticide. The generated intense electrochemical signal with lower potential value enabled sensitive and selective determination of carbofuran up to 1 x 10(-3) mu M with wide sensing window in range of 0.01 to 0.16 mu M. The feasibility of the developed sensor system for the practical application was also studied by testing its potential in real sample extracts of various vegetables. The excellent recoveries demonstrated the analytical robustness of the developed sensor system. The sensor system utilises a new and simple approach towards sensitive determination of toxic pesticides reflecting its wide spectrum application in various fields.

  • 382.
    Ali Soomro, Razium
    et al.
    University of Bristol, England; University of Sindh, Pakistan.
    Hussain Ibupoto, Zafar
    Dr MA Kazi Institute Chemistry University of Sindh, Pakistan.
    Tufail Hussain Sirajuddin; Sherazi, Syed
    University of Sindh, Pakistan.
    Ishaq Abro, Muhammad
    Mehran University of Engn and Technology, Pakistan.
    Willander, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Practice of diclofenac sodium for the hydrothermal growth of NiO nanostructures and their application for enzyme free glucose biosensor2016Ingår i: Microsystem Technologies: Micro- and Nanosystems Information Storage and Processing Systems, ISSN 0946-7076, E-ISSN 1432-1858, Vol. 22, nr 10, s. 2549-2557Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In this study diclofenac sodium (DFS), an analgesic drug has been employed as an effective template for the synthesis of NiO nanostructures. The NiO nanostructures were synthesised using low temperature hydrothermal growth method, both in the presence and absence of the DFS drug. The synthesised nanostructures were studied for their structural, compositional and electrochemical properties using scanning electron microscopy, X-ray diffraction and cyclic voltammetry. The synthesised nanostructures were then utilised for the modification of glassy carbon electrode which were then utilised for the electro-catalytic enzyme free glucose sensing in alkaline media. The competitive experiments suggested that although, both nanostructures possess excellent capability of glucose sensing, the NiO nanoflakes modified electrode was found to be twice as much as sensitive (2584 A mu A mM(-1) cm(-2)) as nanoflowers based electrode (1154 A mu A mM(-1) cm(-2)). The NiO nanoflakes based sensor further demonstrated excellent anti-interference potential in the presence of common interferents like uric acid, ascorbic acid and dopamine. In addition, the successful application NiO nanoflakes based sensor to determine real blood glucose concentration further suggest its feasibility for real sample analysis.

  • 383.
    Ali Soomro, Razium
    et al.
    University of Bristol, England; University of Sindh, Pakistan.
    Nafady, Ayman
    King Saud University, Saudi Arabia; Sohag University, Egypt.
    Hallam, Keith Richard
    University of Bristol, England.
    Jawaid, Sana
    University of Sindh, Pakistan.
    Al Enizi, Abdullah
    King Saud University, Saudi Arabia.
    Tufail Hussain Sherazi, Syed
    University of Sindh, Pakistan.
    Sirajuddin,
    Univ Sindh, Natl Ctr Excellence Analyt Chem, Jamshoro 76080, Pakistan.
    Ibupoto, Zafar Hussain
    Univ Sindh, Dr MA Kazi Inst Chem, Jamshoro 76080, Pakistan.
    Willander, Magnus
    Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
    Highly sensitive determination of atropine using cobalt oxide nanostructures: Influence of functional groups on the signal sensitivity2016Ingår i: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 948, s. 30-39Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This study describes sensitive determination of atropine using glassy carbon electrodes (GCE) modified with Co3O4 nanostructures. The as-synthesised nanostructures were grown using cysteine (CYS), glutathione (GSH) and histidine (HYS) as effective templates under hydrothermal action. The obtained morphologies revealed interesting structural features, including both cavity-based and flower-shaped structures. The as-synthesised morphologies were noted to actively participate in electro-catalysis of atropine (AT) drug where GSH-assisted structures exhibited the best signal response in terms of current density and over-potential value. The study also discusses the influence of functional groups on the signal sensitivity of atropine electro-oxidation. The functionalisation was carried with the amino acids originally used as effective templates for the growth of Co3O4 nanostructures. The highest increment was obtained when GSH was used as the surface functionalising agent. The GSH-functionalised Co3O4-modified electrode was utilised for the electro-chemical sensing of AT in a concentration range of 0.01 -0.46 mu M. The developed sensor exhibited excellent working linearity (R-2 = 0.999) and signal sensitivity up to 0.001 mu M of AT. The noted high sensitivity of the sensor is associated with the synergy of superb surface architectures and favourable interaction facilitating the electron transfer kinetics for the electro-catalytic oxidation of AT. Significantly, the developed sensor demonstrated excellent working capability when used for AT detection in human urine samples with strong anti-interference potential against common co-existing species, such as glucose, fructose, cysteine, uric acid, dopamine and ascorbic acid. (C) 2016 Elsevier B.V. All rights reserved.

  • 384.
    Ali, Wajid
    et al.
    Linköpings universitet, Institutionen för systemteknik, Informationskodning. Linköpings universitet, Tekniska högskolan.
    Mohammed, Shahzaan
    Linköpings universitet, Institutionen för systemteknik, Informationskodning. Linköpings universitet, Tekniska högskolan.
    Analyzing Wavelength Conversion and Traffic Grooming in Optical WDM Networks2013Självständigt arbete på avancerad nivå (magisterexamen), 20 poäng / 30 hpStudentuppsats (Examensarbete)
    Abstract [en]

    Wavelength conversion and traffic grooming have been among the most researched areas and technologies of importance in optical networking. Network performance improves significantly by relaxing the wavelength continuity constraint using wavelength converters and by improving the wavelength utilization using traffic grooming. We have done a literature review that compares the performance of wavelength conversion devices with different traffic grooming devices. This thesis work analyzes the impact of increasing the number of wavelength conversion devices and grooming capable devices using different placement schemes for our proposed network model, traffic loads and link capacities. Deciding the number and location of these devices to be used in a network is equally important. This work has been done through the simulation of different device placement scenarios and the results have been analyzed using connection blocking probability as the performance metric. Our reviews and work, correctly predict the behavior of results as demonstrated by the results of other referred literatures relating to wavelength conversion and traffic grooming.

  • 385.
    Alimelli, Adriano
    et al.
    Dept of Electronic Engineering University of Rome.
    Filippini, Daniel
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik.
    Paolesse, Roberto
    dept of Chemical science and technology University of Rome.
    Moretti, Simonetta
    Instituto sperimentale per l´enologia.
    Ciolfi, Gaetano
    Instituto sperimentale per l´enologia.
    D´Amico, Arnaldo
    Dept. of Electronic Engineering University of Rome.
    Lundström, Ingemar
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik.
    Di Natale, Corradeo
    Dept. of Electronic Engineering University of Rome.
    Direct quantitative evaluation of complex substances using computer screen photo-assisted technology: The case of red wine2007Ingår i: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 597, s. 103-112Artikel i tidskrift (Refereegranskat)
  • 386. Alimelli, Adriano
    et al.
    Pennazza, Giorgio
    Santonico, Marco
    Paolesse, Roberto
    University of Rome, Italy.
    Filippini, Daniel
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik.
    D´Amico, Arnaldo
    University of Rome, Italy.
    Lundström, Ingemar
    Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för fysik, kemi och biologi, Tillämpad Fysik.
    Di Natale, Corrado
    University of Rome, Italy.
    Fish freshness detection by a computer screen photoassisted based gas sensor array2007Ingår i: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 582, nr 2, s. 320-328Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In the last years a large number of different measurement methodologies were applied to measure the freshness of fishes. Among them the connection between freshness and headspace composition has been considered by gas chromatographic analysis and from the last two decades by a number of sensors and biosensors aimed at measuring some characteristic indicators (usually amines). More recently also the so-called artificial olfaction systems gathering together many non-specific sensors have shown a certain capability to transduce the global composition of the fish headspace capturing the differences between fresh and spoiled products. One of the main objectives related to the introduction of sensor systems with respect to the analytical methods is the claimed possibility to distribute the freshness control since sensors are expected to be "portable" and "simple". In spite of these objectives, until now sensor systems did not result in any tool that may be broadly distributed. In this paper, we present a chemical sensor array where the optical features of layers of chemicals, sensitive to volatile compounds typical of spoilage processes in fish, are interrogated by a very simple platform based on a computer screen and a web cam. An array of metalloporphyrins is here used to classify fillets of thawed fishes according to their storage days and to monitor the spoilage in filleted anchovies for a time of 8 h. Results indicate a complete identification of the storage days of thawed fillets and a determination of the storage time of anchovies held at room temperature with a root mean square error of validation of about 30 min. The optical system produces a sort of spectral fingerprint containing information about both the absorbance and the emission of the sensitive layer. The system here illustrated, based on computer peripherals, can be easily scaled to any device endowed with a programmable screen and a camera such as cellular phones offering for the first time the possibility to fulfil the sensor expectation of diffused and efficient analytical capabilities. © 2006 Elsevier B.V. All rights reserved.

  • 387.
    Alirezaie, Marjan
    Linköpings universitet, Institutionen för datavetenskap.
    Semantic Analysis Of Multi Meaning Words Using Machine Learning And Knowledge Representation2011Självständigt arbete på avancerad nivå (masterexamen), 30 poäng / 45 hpStudentuppsats (Examensarbete)
    Abstract [en]

    The present thesis addresses machine learning in a domain of naturallanguage phrases that are names of universities. It describes two approaches to this problem and a software implementation that has made it possible to evaluate them and to compare them.

    In general terms, the system's task is to learn to 'understand' the significance of the various components of a university name, such as the city or region where the university is located, the scienti c disciplines that are studied there, or the name of a famous person which may be part of the university name. A concrete test for whether the system has acquired this understanding is when it is able to compose a plausible university name given some components that should occur in the name.

    In order to achieve this capability, our system learns the structure of available names of some universities in a given data set, i.e. it acquires a grammar for the microlanguage of university names. One of the challenges is that the system may encounter ambiguities due to multi meaning words. This problem is addressed using a small ontology that is created during the training phase.

    Both domain knowledge and grammatical knowledge is represented using decision trees, which is an ecient method for concept learning. Besides for inductive inference, their role is to partition the data set into a hierarchical structure which is used for resolving ambiguities.

    The present report also de nes some modi cations in the de nitions of parameters, for example a parameter for entropy, which enable the system to deal with cognitive uncertainties. Our method for automatic syntax acquisition, ADIOS, is an unsupervised learning method. This method is described and discussed here, including a report on the outcome of the tests using our data set.

    The software that has been implemented and used in this project has been implemented in C.

  • 388.
    Alirezaie, Marjan
    et al.
    Institutionen för naturvetenskap och teknik , Örebro Universitet.
    Hammar, Karl
    Högskolan i Jönköping, JTH, Datateknik och informatik.
    Blomqvist, Eva
    Linköpings universitet, Institutionen för datavetenskap, Interaktiva och kognitiva system. Linköpings universitet, Tekniska fakulteten.
    Nyström, Mikael
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
    Ivanova, Valentina
    Linköpings universitet, Institutionen för datavetenskap, Databas och informationsteknik. Linköpings universitet, Tekniska fakulteten.
    SmartEnv Ontology in E-care@home2018Ingår i: SSN 2018 - Semantic Sensor Networks Workshop: Proceedings of the 9th International Semantic Sensor Networks Workshopco-located with 17th International Semantic Web Conference (ISWC 2018) / [ed] Maxime Lefrançois, Raúl Garcia Castro, Amélie Gyrard, Kerry Taylor, CEUR-WS , 2018, Vol. 2213, s. 72-79Konferensbidrag (Refereegranskat)
    Abstract [en]

    In this position paper we briefly introduce SmartEnv ontology which relies on SEmantic Sensor Network (SSN) ontology and is used to represent different aspects of smart and sensorized environments. We will also talk about E-carehome project aiming at providing an IoT-based health-care system for elderly people at their homes. Furthermore, we refer to the role of SmartEnv in Ecarehome and how it needs to be further extended to achieve semantic interoperability as one of the challenges in development of autonomous health care systems at home.

  • 389.
    Alizadeh, Javad
    et al.
    University of Manitoba, Canada.
    Zeki, Amir A.
    Centre Comparat Resp Biol and Med, CA USA.
    Mirzaei, Nima
    University of Manitoba, Canada.
    Tewary, Sandipan
    University of Manitoba, Canada.
    Rezaei Moghadam, Adel
    University of Manitoba, Canada; University of Manitoba, Canada.
    Glogowska, Aleksandra
    University of Manitoba, Canada.
    Nagakannan, Pandian
    University of Manitoba, Canada.
    Eftekharpour, Eftekhar
    University of Manitoba, Canada.
    Wiechec, Emilia
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Logopedi, Audiologi och Otorhinolaryngologi. Linköpings universitet, Medicinska fakulteten.
    Gordon, Joseph W.
    University of Manitoba, Canada; University of Manitoba, Canada; University of Manitoba, Canada.
    Xu, Fred. Y.
    University of Manitoba, Canada; University of Manitoba, Canada.
    Field, Jared T.
    University of Manitoba, Canada.
    Yoneda, Ken Y.
    Centre Comparat Resp Biol and Med, CA USA.
    Kenyon, Nicholas J.
    Centre Comparat Resp Biol and Med, CA USA.
    Hashemi, Mohammad
    Zehedan University of Medical Science, Iran.
    Hatch, Grant M.
    University of Manitoba, Canada; University of Manitoba, Canada.
    Hombach-Klonisch, Sabine
    University of Manitoba, Canada.
    Klonisch, Thomas
    University of Manitoba, Canada.
    Ghavami, Saeid
    University of Manitoba, Canada; University of Manitoba, Canada; Shiraz University of Medical Science, Iran.
    Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells2017Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, artikel-id 44841Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and farnesylpyrophosphate (FPP) used in the prenylation of proteins. Here we show that the MEV cascade inhibitor simvastatin induced significant cell death in a wide range of human tumor cell lines, including glioblastoma, astrocytoma, neuroblastoma, lung adenocarcinoma, and breast cancer. Simvastatin induced apoptotic cell death via the intrinsic apoptotic pathway. In all cancer cell types tested, simvastatin-induced cell death was not rescued by cholesterol, but was dependent on GGPP-and FPP-depletion. We confirmed that simvastatin caused the translocation of the small Rho GTPases RhoA, Cdc42, and Rac1/2/3 from cell membranes to the cytosol in U251 (glioblastoma), A549 (lung adenocarcinoma) and MDA-MB231( breast cancer). Simvastatin-induced Rho-GTP loading significantly increased in U251 cells which were reversed with MEV, FPP, GGPP. In contrast, simvastatin did not change Rho-GTP loading in A549 and MDA-MB-231. Inhibition of geranylgeranyltransferase I by GGTi-298, but not farnesyltransferase by FTi-277, induced significant cell death in U251, A549, and MDA-MB-231. These results indicate that MEV cascade inhibition by simvastatin induced the intrinsic apoptosis pathway via inhibition of Rho family prenylation and depletion of GGPP, in a variety of different human cancer cell lines.

  • 390.
    Alkaissi, Hammoudi
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Identification of candidate genes involved in Mercury Toxicokinetics and Mercury Induced Autoimmunity2018Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    BACKGROUND: Autoimmune diseases require the involvement and activation of immune cells and occur when the body builds up an immune response against its own tissues. This process takes place due to the inability to distinguish self-antigen from foreign antigen. Systemic autoimmunity represents an important cause of morbidity and mortality in humans. The mechanisms triggering autoimmune responses are complex and involve a network of genetic factors. Genome wide association study (GWAS) is a powerful method, used to identify genetic risk factors in numerous diseases, such as systemic autoimmune diseases. The goal of GWAS is to identify these genetic risk factors in order to make predictions about who is at risk and investigate the biological process of disease susceptibility. There are several valuable mouse models to investigate the underlying mechanisms causing systemic autoimmune diseases in which mercury induced autoimmunity (HgIA) is a well- established and relevant model. HgIA in mice includes development of autoantibodies, immune complex glomerulonephritis, lymphocyte proliferation, hypergammaglobulinemia and polyclonal B cell activation. In humans, mercury exposure accumulates with considerable concentrations in kidney, liver, and brain. Toxicokinetics of Hg has been studied extensively but the key for inter-individual variation in humans are largely unclear. Differences in accumulation of renal Hg between inbred mouse strains suggest a genetic inter-strain variation regulating retention or/and excretion of Hg.

    OBJECTIVES: To find loci and candidate genes associated with phenotypes involved in the development of autoimmunity and find candidate genes involved in the regulation of renal Hg excretion.

    METHODS: MHC II (H-2s) mice were paired (A.SW x B10.S) to obtain F2 offspring exposed to 2.0 or 4.0 mg Hg in drinking water for 6 weeks. Mercury induced autoimmune phenotypes were studied with immunofluorescence (anti-nucleolar antibodies (ANoA)), ELISA anti-DNP/anti-ssDNA (polyclonal B cell activation), anti-chromatin antibodies (ACA) (4.0 mg Hg), and serum IgG1 concentrations. Mercury accumulation in kidney was performed previously and data was included as phenotype. F2 mice exposed to 2.0 mg Hg were genotyped with microsatellites for genome-wide scan with Ion Pair Reverse Phase High Performance Liquid Chromatography (IP RP HPLC). F2 mice exposed to 4.0 mg Hg were genotyped with single nucleotide polymorphisms for genomewide scan with SNP&SEQ technology platform. Quantitative trait loci (QTL) was established with R/QTL. Denaturing HPLC, next generation sequencing, conserved region analysis and genetic mouse strain comparison were used for haplotyping and fine mapping on QTLs associated with Hg concentration in kidney, development of ANoA and serum IgG1 hypergammaglobulinemia. Candidate genes (Pprc1, Bank1 and Nfkb1) verified by additional QTL were further investigated by real time polymerase chain reaction. Genes involved in the intracellular signaling together with candidate genes were included for gene expression analysis.

    RESULTS: F2 mice exposed to 2.0 mg Hg had low or no development of autoantibodies and showed no significant difference in polyclonal B cell activation in the B10.S and F2 strains. F2 mice exposed to 4.0 mg Hg developed autoantibodies and significantly increased IgG1 concentration and polyclonal B cell activation (anti-DNP). QTL analysis showed a logarithm of odds ratio (LOD) score between 2.9 – 4.36 on all serological phenotypes exposed to 4.0 mg Hg, and a LOD score of 5.78 on renal Hg concentration. Haplotyping and fine mapping associated the development of ANoA with Bank1 (B-cell scaffold protein with ankyrin repeats 1) and Nfkb1 (nuclear factor kappa B subunit 1). The serum IgG1 concentration was associated with a locus on chromosome 3, in which Rxfp4 (Relaxin Family Peptide/INSL5 Receptor 4) is a potential candidate gene. The renal Hg concentration was associated with Pprc1 (Peroxisome Proliferator-Activated Receptor Gamma, Co-activator-Related). Gene expression analysis revealed that the more susceptible A.SW strain expresses significantly higher levels of Nfkb1, Il6 and Tnf than the less susceptible B10.S strain. The A.SW strain expresses significantly lower levels of Pprc1 and cascade proteins than the B10.S strain. Development of ACA was associated with chromosomes 3, 6, 7 and 16 (LOD 3.1, 3.2, 3.4 and 6.8 respectively). Polyclonal B cell activation was associated with chromosome 2 with a LOD score of 2.9.

    CONCLUSIONS: By implementing a GWAS on HgIA in mice, several QTLs were discovered to be associated with the development of autoantibodies, polyclonal B cell activation and hypergammaglobulinemia. This thesis plausibly supports Bank1 and Nfkb1 as key regulators for ANoA development and HgIA seems to be initiated by B cells rather than T cells. GWAS on renal mercury excretion plausibly supports Pprc1 as key regulator and it seems that this gene has a protective role against Hg.

    Delarbeten
    1. Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice
    Öppna denna publikation i ny flik eller fönster >>Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice
    Visa övriga...
    2016 (Engelska)Ingår i: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 124, nr 7, s. 920-926Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    BACKGROUND: Following human mercury (Hg) exposure, the metal accumulates in considerable concentrations in kidney, liver, and brain. Although the toxicokinetics of Hg have been studied extensively, factors responsible for interindividual variation in humans are largely unknown. Differences in accumulation of renal Hg between inbred mouse strains suggest a genetic interstrain variation regulating retention or/and excretion of Hg. A. SW, DBA/2 and BALB/C mouse strains accumulate higher amounts of Hg than B10.S.

    OBJECTIVES: We aimed to find candidate genes associated with regulation of renal Hg concentrations.

    METHODS: A. SW, B10.S and their F1 and F2 offspring were exposed for 6 weeks to 2.0 mg Hg/L drinking water. Genotyping with microsatellites was conducted on 84 F2 mice for genome-wide scanning with ion pair reverse-phase high-performance liquid chromatography (IP RP HPLC). Quantitative trait loci (QTL) were established. Denaturing HPLC was used to detect single nucleotide polymorphisms for haplotyping and fine mapping in 184 and 32 F2 mice, respectively. Candidate genes (Pprc1, Btrc and Nfkb2) verified by fine mapping and QTL were further investigated by real-time polymerase chain reaction. Genes enhanced by Pprc1 (Nrf1 and Nrf2) were included for gene expression analysis.

    RESULTS: Renal Hg concentrations differed significantly between A. SW and B10. S mice and between males and females within each strain. QTL analysis showed a peak logarithm of odds ratio score 5.78 on chromosome 19 (p = 0.002). Haplotype and fine mapping associated the Hg accumulation with Pprc1, which encodes PGC-1-related coactivator (PRC), a coactivator for proteins involved in detoxification. Pprc1 and two genes coactivated by Pprc1 (Nrf1 and Nrf2) had significantly lower gene expression in the A. SW strain than in the B10. S strain.

    CONCLUSIONS: This study supports Pprc1 as a key regulator for renal Hg excretion.

    Ort, förlag, år, upplaga, sidor
    U.S. Department of Health and Human Services * National Institute of Environmental Health Sciences, 2016
    Nationell ämneskategori
    Annan biologi
    Identifikatorer
    urn:nbn:se:liu:diva-131584 (URN)10.1289/ehp.1409284 (DOI)000380749300012 ()26942574 (PubMedID)
    Anmärkning

    Funding Agencies|Swedish Research Council Branch of Medicine; County Council of Ostergotland; Linkoping University

    Tillgänglig från: 2016-09-27 Skapad: 2016-09-27 Senast uppdaterad: 2018-10-24Bibliografiskt granskad
    2. Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development
    Öppna denna publikation i ny flik eller fönster >>Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development
    Visa övriga...
    2018 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 7, artikel-id e0199979Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Systemic autoimmune rheumatic disorders (SARD) represent important causes of morbidity and mortality in humans. The mechanisms triggering autoimmune responses are complex and involve a network of genetic factors. Mercury-induced autoimmunity (HgIA) in mice is an established model to study the mechanisms of the development of antinuclear antibodies (ANA), which is a hallmark in the diagnosis of SARD. A.SW mice with HgIA show a significantly higher titer of antinucleolar antibodies (ANoA) than the B10.S mice, although both share the same MHC class II (H-2). We applied a genome-wide association study (GWAS) to their Hg-exposed F2 offspring to investigate the non-MHC genes involved in the development of ANoA. Quantitative trait locus (QTL) analysis showed a peak logarithm of odds ratio (LOD) score of 3.05 on chromosome 3. Microsatellites were used for haplotyping, and fine mapping was conducted with next generation sequencing. The candidate genes Bank1 (B-cell scaffold protein with ankyrin repeats 1) and Nfkbl (nuclear factor kappa B subunit 1) were identified by additional QTL analysis. Expression of the Bank1 and Nfkb1 genes and their downstream target genes involved in the intracellular pathway (Tlr9,II6, Tnf) was investigated in mercury-exposed A.SW and B10.S mice by real-time PCR. Bank1 showed significantly lower gene expression in the A.SW strain after Hg-exposure, whereas the B10.S strain showed no significant difference. Nfkb1, Tlr9, II6 and Tnf had significantly higher gene expression in the A.SW strain after Hg-exposure, while the B10.S strain showed no difference. This study supports the roles of Bank1 (produced mainly in B-cells) and Nfkbl (produced in most immune cells) as key regulators of ANoA development in HgIA.

    Ort, förlag, år, upplaga, sidor
    PUBLIC LIBRARY SCIENCE, 2018
    Nationell ämneskategori
    Genetik
    Identifikatorer
    urn:nbn:se:liu:diva-150265 (URN)10.1371/journal.pone.0199979 (DOI)000438866600014 ()30016332 (PubMedID)
    Anmärkning

    Funding Agencies|Swedish Research Council Branch of Medicine; County Council of Ostergotland; Linkoping University

    Tillgänglig från: 2018-08-17 Skapad: 2018-08-17 Senast uppdaterad: 2019-04-24
  • 391.
    Alkaissi, Hammoudi
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
    Ekstrand, Jimmy
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
    Jawad, Aksa
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
    Nielsen, Jesper Bo
    University of Southern Denmark, Denmark.
    Havarinasab, Said
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
    Söderkvist, Peter
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
    Hultman, Per
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
    Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice2016Ingår i: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 124, nr 7, s. 920-926Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Following human mercury (Hg) exposure, the metal accumulates in considerable concentrations in kidney, liver, and brain. Although the toxicokinetics of Hg have been studied extensively, factors responsible for interindividual variation in humans are largely unknown. Differences in accumulation of renal Hg between inbred mouse strains suggest a genetic interstrain variation regulating retention or/and excretion of Hg. A. SW, DBA/2 and BALB/C mouse strains accumulate higher amounts of Hg than B10.S.

    OBJECTIVES: We aimed to find candidate genes associated with regulation of renal Hg concentrations.

    METHODS: A. SW, B10.S and their F1 and F2 offspring were exposed for 6 weeks to 2.0 mg Hg/L drinking water. Genotyping with microsatellites was conducted on 84 F2 mice for genome-wide scanning with ion pair reverse-phase high-performance liquid chromatography (IP RP HPLC). Quantitative trait loci (QTL) were established. Denaturing HPLC was used to detect single nucleotide polymorphisms for haplotyping and fine mapping in 184 and 32 F2 mice, respectively. Candidate genes (Pprc1, Btrc and Nfkb2) verified by fine mapping and QTL were further investigated by real-time polymerase chain reaction. Genes enhanced by Pprc1 (Nrf1 and Nrf2) were included for gene expression analysis.

    RESULTS: Renal Hg concentrations differed significantly between A. SW and B10. S mice and between males and females within each strain. QTL analysis showed a peak logarithm of odds ratio score 5.78 on chromosome 19 (p = 0.002). Haplotype and fine mapping associated the Hg accumulation with Pprc1, which encodes PGC-1-related coactivator (PRC), a coactivator for proteins involved in detoxification. Pprc1 and two genes coactivated by Pprc1 (Nrf1 and Nrf2) had significantly lower gene expression in the A. SW strain than in the B10. S strain.

    CONCLUSIONS: This study supports Pprc1 as a key regulator for renal Hg excretion.

  • 392.
    Alkaissi, Hammoudi
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Havarinasab, Said
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Nielsen, Jesper Bo
    Univ Southern Denmark, Denmark.
    Söderkvist, Peter
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk genetik.
    Hultman, Per
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk patologi.
    Bank1 and NF-kappaB as key regulators in anti-nucleolar antibody development2018Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 13, nr 7, artikel-id e0199979Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Systemic autoimmune rheumatic disorders (SARD) represent important causes of morbidity and mortality in humans. The mechanisms triggering autoimmune responses are complex and involve a network of genetic factors. Mercury-induced autoimmunity (HgIA) in mice is an established model to study the mechanisms of the development of antinuclear antibodies (ANA), which is a hallmark in the diagnosis of SARD. A.SW mice with HgIA show a significantly higher titer of antinucleolar antibodies (ANoA) than the B10.S mice, although both share the same MHC class II (H-2). We applied a genome-wide association study (GWAS) to their Hg-exposed F2 offspring to investigate the non-MHC genes involved in the development of ANoA. Quantitative trait locus (QTL) analysis showed a peak logarithm of odds ratio (LOD) score of 3.05 on chromosome 3. Microsatellites were used for haplotyping, and fine mapping was conducted with next generation sequencing. The candidate genes Bank1 (B-cell scaffold protein with ankyrin repeats 1) and Nfkbl (nuclear factor kappa B subunit 1) were identified by additional QTL analysis. Expression of the Bank1 and Nfkb1 genes and their downstream target genes involved in the intracellular pathway (Tlr9,II6, Tnf) was investigated in mercury-exposed A.SW and B10.S mice by real-time PCR. Bank1 showed significantly lower gene expression in the A.SW strain after Hg-exposure, whereas the B10.S strain showed no significant difference. Nfkb1, Tlr9, II6 and Tnf had significantly higher gene expression in the A.SW strain after Hg-exposure, while the B10.S strain showed no difference. This study supports the roles of Bank1 (produced mainly in B-cells) and Nfkbl (produced in most immune cells) as key regulators of ANoA development in HgIA.

  • 393.
    Al-kfairy, Mousa
    Linköpings universitet, Institutionen för datavetenskap.
    Toward Agile development methods & Non-functional requirements2009Självständigt arbete på avancerad nivå (masterexamen), 30 poäng / 45 hpStudentuppsats (Examensarbete)
    Abstract [en]

    In this thesis, we tried to solve those problems by adapting agile development methods with Non-functional requirements-framework (NFR-Framework).

    In this thesis, we have inspected many research papers, and we have met industrial experts for feedback regarding our theoretical results.

    As a result of the inspection, we have been able to adapt agile development methods (extreme programming (XP)) with NFR-framework. We use XP since it is more practically oriented process than other agile development methods.

    In the first try for this process model, we got three alternatives for applying it. The first one is based on collecting all NFRs from the beginning of the development process. The second one is based on updating the SIG (software interdependency graph) every time we have new functional requirements (FR) and the third one is based on the incremental nature of agile development methods.

    Each one of these alternatives has it is own advantages and disadvantages. We tried to extract those advantages and disadvantages by brainstorming and reading research papers. The most important issue in all of the three alternatives is the applicability. Finally we got industrial feedback regarding all of them.

    As a result of the industrial feedback, we were able to find another alternative of how to apply the process model which is presented in 7.2.

  • 394.
    Alkmyr, Pierre
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Informatik. Linköpings universitet, Filosofiska fakulteten.
    Karlström, Erik
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Informatik. Linköpings universitet, Filosofiska fakulteten.
    Att arbeta agilt med icke-agila krav: En studie om den offentliga upphandlingens påverkan på ett agilt IS-projekts kravhantering med den offentliga sektorn som kontext2019Självständigt arbete på grundnivå (kandidatexamen), 10 poäng / 15 hpStudentuppsats (Examensarbete)
    Abstract [sv]

    Sverige har som mål att bli bäst i världen på att nyttja digitaliseringens möjligheter för att skapa effektiv verksamhet i offentlig sektor och en enklare vardag för privatpersoner och företag. År 2017 spenderades 59 miljarder svenska kronor på att digitalisera Sverige med hjälp av externa aktörer. Trots miljardsatsningen är Sveriges utvecklingstakt långsam i jämförelse med flera andra länder i Europa. Svenska myndigheten Riksrevisionen har dessutom identifierat att IT-projekt ofta drar över budget och konstaterar att offentliga verksamheter måste effektivisera sin IT-verksamhet. IT-projekt, inte bara i offentlig sektor, har visat en trend på att dra över budget eller tid och i ett försök att möta denna problematik har den agila filosofin och olika agila projektmodeller vuxit fram. Det agila projektförfarandet har överlag haft en positiv påverkan på IT-projekt och har anammats i en högre utsträckning i den privata sektorn än den offentliga sektorn. 

    Då det läggs flera miljarder på upphandlingar av IT har vi sett det som viktigt att samverkan med extern part fungerar bra och att projekten effektiviseras. Eftersom den agila projektmodellen visat sig ha en positiv påverkan på IT-projekt har denna studie därför undersökt vilka förutsättningar som finns för att driva IT-projekt agilt mot offentlig sektor. Upphandlingsprocessen och hur den påverkar möjligheten att tillämpa en agil projektmodell har fått särskilt mycket uppmärksamhet i vår studie då lagen om offentlig upphandling (SFS 2016:1145) innebär att den kravspecifikation som skrivs av den upphandlande parten blir svårföränderlig.

    I vår fallstudie har vi undersökt ett implementationsprojekt i en offentlig verksamhet som drivits med en agil ansats av en extern leverantör i privat sektor. Genom att intervjua respondenter på leverantören, som var involverade i projektet, har vi tillämpat ett leverantörsperspektiv i vår undersökning för att kartlägga upplevda utmaningar i projekt mot offentlig verksamhet. Utifrån empirin har vi kommit fram till att upphandlingsförfarandet lett till att det uppstått (1) utmaningar vid ändring kravspecifikation och att bevisa uppfyllelse av krav, (2) kommunikationssvårigheter mellan Kunden och Leverantören gällande krav och (3) upplevd bristande förståelse för kraven av kunden. Vissa organisatoriska karaktärsdrag för offentlig verksamhet har också identifierats som bidragande till kommunikationssvårigheter mellan Kunden och Leverantören gällande krav. Den agila filosofin förespråkar ett nära samarbete med intressenter och förutsätter förändringar av kravspecifikationen genomgående i projektet. Slutsatsen är således att upphandlingsprocessen, i det studerade projektet, har påverkat möjligheterna för att driva IT-projekt agilt. 

  • 395.
    Allahverdiyeva, Yagut
    et al.
    University of Turku.
    Mamedov, Fikret
    Uppsala University.
    Holmstrom, Maija
    University of Turku.
    Nurmi, Markus
    University of Turku.
    Lundin, Björn
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Styring, Stenbjorn
    Uppsala University.
    Spetea Wiklund, Cornelia
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Aro, Eva-Mari
    University of Turku.
    Comparison of the electron transport properties of the psbo1 and psbo2 mutants of Arabidopsis thaliana2009Ingår i: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, ISSN 0005-2728, Vol. 1787, nr 10, s. 1230-1237Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Genome sequence of Arabidopsis thaliana (Arabidopsis) revealed two psbO genes (At5g66570 and At3g50820) which encode two distinct PsbO isoforms: PsbO1 and PsbO2, respectively. To get insights into the function of the PsbO1 and PsbO2 isoforms in Arabidopsis we have performed systematic and comprehensive investigations of the whole photosynthetic electron transfer chain in the T-DNA insertion mutant lines, psbO1 and psbo2. The absence of the PsbO1 isoform and presence of only the PsbO2 isoform in the psbo1 mutant results in (i) malfunction of both the donor and acceptor sides of Photosystem (PS) 11 and (ii) high sensitivity of PSII centers to photodamage, thus implying the importance of the PsbO1 isoform for proper structure and function of PSII. The presence of only the PsbO2 isoform in the PSII centers has consequences not only to the function of PSII but also to the PSI/PSII ratio in thylakoids. These results in modification of the whole electron transfer chain with higher rate of cyclic electron transfer around PSI, faster induction of NPQ and a larger size of the PQ-pool compared to WT, being in line with apparently increased chlororespiration in the psbo1 mutant plants. The presence of only the PsbO1 isoform in the psbo2 mutant did not induce any significant differences in the performance of PSII under standard growth conditions as compared to WT. Nevertheless, under high light illumination, it seems that the presence of also the PsbO2 isoform becomes favourable for efficient repair of the PSII complex.

  • 396.
    Allan, Douglas W
    et al.
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.
    St Pierre, Susan E
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.
    Miguel-Aliaga, Irene
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.
    Thor, Stefan
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.
    Specification of Neuropeptide Cell Identity by the Integration of Retrograde BMP Signaling and a Combinatorial Transcription Factor Code2003Ingår i: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 113, nr 1, s. 73-86Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Individual neurons express only one or a few of the many identified neurotransmitters and neuropeptides, but the molecular mechanisms controlling their selection are poorly understood. In the Drosophila ventral nerve cord, the six Tv neurons express the neuropeptide gene FMRFamide. Each Tv neuron resides within a neuronal cell group specified by the LIM-homeodomain gene apterous. We find that the zinc-finger gene squeeze acts in Tv cells to promote their unique axon pathfinding to a peripheral target. There, the BMP ligand Glass bottom boat activates the Wishful thinking receptor, initiating a retrograde BMP signal in the Tv neuron. This signal acts together with apterous and squeeze to activate FMRFamide expression. Reconstituting this "code," by combined BMP activation and apterous/squeeze misexpression, triggers ectopic FMRFamide expression in peptidergic neurons. Thus, an intrinsic transcription factor code integrates with an extrinsic retrograde signal to select a specific neuropeptide identity within peptidergic cells.

  • 397.
    Allan, D.W.
    et al.
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, United States, Department of Neurology, 211 Enders, Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, United States.
    Park, D.
    Dept. of Anatomy and Neurobiology, Washington University, School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, United States.
    St., Pierre S.E.
    St. Pierre, S.E., Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, United States, Cutaneous Biology Research Center, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, United States.
    Taghert, P.H.
    Dept. of Anatomy and Neurobiology, Washington University, School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, United States.
    Thor, Stefan
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Regulators acting in combinatorial codes also act independently in single differentiating neurons2005Ingår i: Neuron, ISSN 0896-6273, E-ISSN 1097-4199, Vol. 45, nr 5, s. 689-700Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In the Drosophila ventral nerve cord, a small number of neurons express the LIM-homeodomain gene apterous (ap). These ap neurons can be subdivided based upon axon pathfinding and their expression of neuropeptidergic markers. ap, the zinc finger gene squeeze, the bHLH gene dimmed, and the BMP pathway are all required for proper specification of these cells. Here, using several ap neuron terminal differentiation markers, we have resolved how each of these factors contributes to ap neuron diversity. We find that these factors interact genetically and biochemically in subtype-specific combinatorial codes to determine certain defining aspects of ap neuron subtype identity. However, we also find that ap, dimmed, and squeeze additionally act independently of one another to specify certain other defining aspects of ap neuron subtype identity. Therefore, within single neurons, we show that single regulators acting in numerous molecular contexts differentially specify multiple subtype-specific traits. Copyright ©2005 by Elsevier Inc.

  • 398.
    Allard, Alexandra
    et al.
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling. Linköpings universitet, Filosofiska fakulteten.
    Takman, Johanna
    Swedish Natl Rd and Transport Res Inst, Sweden.
    Uddin, Gazi Salah
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Nationalekonomi. Linköpings universitet, Filosofiska fakulteten.
    Ahmed, Ali
    Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, Nationalekonomi. Linköpings universitet, Filosofiska fakulteten.
    The N-shaped environmental Kuznets curve: an empirical evaluation using a panel quantile regression approach2018Ingår i: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 25, nr 6, s. 5848-5861Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    We evaluate the N-shaped environmental Kuznets curve (EKC) using panel quantile regression analysis. We investigate the relationship between CO2 emissions and GDP per capita for 74 countries over the period of 1994-2012. We include additional explanatory variables, such as renewable energy consumption, technological development, trade, and institutional quality. We find evidence for the N-shaped EKC in all income groups, except for the upper-middle-income countries. Heterogeneous characteristics are, however, observed over the N-shaped EKC. Finally, we find a negative relationship between renewable energy consumption and CO2 emissions, which highlights the importance of promoting greener energy in order to combat global warming.

  • 399.
    Allard, Bert
    et al.
    Linköpings universitet, Institutionen för tema, Tema vatten i natur och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Borén, HansLinköpings universitet, Institutionen för tema, Tema vatten i natur och samhälle. Linköpings universitet, Filosofiska fakulteten.Grimvall, AndersLinköpings universitet, Institutionen för tema, Tema vatten i natur och samhälle. Linköpings universitet, Filosofiska fakulteten.
    Humic substances in the aquatic and terrestrial environment : proceedings of an international symposium, Linköping, Sweden, August 21-23, 19891991Proceedings (redaktörskap) (Refereegranskat)
    Abstract [en]

    The state of the art on isolation techniques, ion binding theory, biologic activity in the aquatic environment as well as the formation of mutagenic compounds from chlorination is reviewed by worldwide-known experts. Additional papers describe current research on the topics: isolation, fractionation and characterization; biological and chemical transformation and degradation; complex formation and interactions with solids; biologic activity, halogenation of humic substances.

  • 400.
    Alling, Björn
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Teoretisk Fysik. Linköpings universitet, Tekniska högskolan.
    Configurational and Magnetic Interactions in Multicomponent Systems2010Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [en]

    This thesis is a theoretical study of configurational and magnetic interactions in multicomponent solids. These interactions are the projections onto the configurational and magnetic degrees of freedom of the underlying electronic quantum mechanical system, and can be used to model, explain and predict the properties of materials. For example, the interactions govern temperature induced configurational and magnetic order-disorder transitions in Heusler alloys and ternary nitrides.

    In particular three perspectives are studied. The first is how the interactions can be derived from first-principles calculations at relevant physical conditions. The second is their consequences, like the critical temperatures for disordering, obtained with e.g. Monte Carlo simulations. The third is their origin in terms of the underlying electronic structure of the materials.

    Intrinsic defects in the half-Heusler system NiMnSb are studied and it is found that low-energy defects do not destroy the important half-metallic property at low concentrations. Deliberate doping of NiMnSb with 3d-metals is considered and it is found that replacing some Ni with extra Mn or Cr creates new strong magnetic interactions which could be beneficial for applications at elevated temperature. A self-consistent scheme to include the effects of thermal expansion and one-electron excitations in the calculation of the magnetic critical temperature is introduced and applied to a study of Ni1−xCuxMnSb.

    A supercell implementation of the disordered local moments approach is suggested and benchmarked for the treatment of paramagnetic CrN as a disordered magnetic phase. It is found that the orthorhombic-to-cubic phase transition in this nitride can be understood as a first-order magnetic order-disorder transition. The ferromagnetism in Ti1−xCrxN solid solutions, an unusual property in nitrides, is explained in terms of a charge transfer induced change in the Cr-Cr magnetic interactions.

    Cubic Ti1−xAlxN solid solutions displays a complex and concentration dependent phase separation tendency. A unified cluster expansion method is presented that can be used to simulate the configurational thermodynamics of this system. It is shown that short range clustering do influence the free energy of mixing but only slightly change the isostructural phase diagram as compared to mean-field estimates.

    Delarbeten
    1. Role of stoichiometric and nonstoichiometric defects on the magnetic properties of the half-metallic ferromagnet NiMnSb
    Öppna denna publikation i ny flik eller fönster >>Role of stoichiometric and nonstoichiometric defects on the magnetic properties of the half-metallic ferromagnet NiMnSb
    2006 (Engelska)Ingår i: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 73, nr 6, s. 064418-Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    The first material to be predicted from first-principles calculations as half-metallic was NiMnSb, and the research on this material has been intense due to its possible applications in spintronics devices. The failure of many experiments to measure spin polarization to more than a fraction of the predicted 100% has partly been blamed on structural defects. In this work a complete first-principles treatise of point defects, including nonstoichiometric antisites, interstitial and vacancy defects, as well as stoichiometric atomic swap defects in NiMnSb, is presented. We find that the formation energies of the defects span a large scale from 0.2 to 14.4 eV. The defects with low formation energies preserve the half-metallic character of the material. We also find that some of the defects increase the magnetic moment and thus can explain the experimentally observed increase of magnetic moments in some samples of NiMnSb. Most interesting in this respect are Mn interstitials which increase the magnetic moment, have a low formation energy, and keep the half-metallic character of the material.

    Nyckelord
    nickel alloys, manganese alloys, antimony alloys, ferromagnetic materials, ab initio calculations, interstitials, antisite defects, vacancies (crystal), defect states, magnetic moments
    Nationell ämneskategori
    Naturvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-35025 (URN)10.1103/PhysRevB.73.064418 (DOI)24646 (Lokalt ID)24646 (Arkivnummer)24646 (OAI)
    Anmärkning
    Original Publication: Björn Alling, Sam Shallcross and Igor Abrikosov, Role of stoichiometric and nonstoichiometric defects on the magnetic properties of the half-metallic ferromagnet NiMnSb, 2006, Physical Review B. Condensed Matter and Materials Physics, (73), 6, 064418. http://dx.doi.org/10.1103/PhysRevB.73.064418 Copyright: American Physical Society http://www.aps.org/ Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2017-12-13
    2.
    Posten kunde inte hittas. Det kan bero på att posten inte längre är tillgänglig eller att du har råkat ange ett felaktigt id i adressfältet.
    3.
    Posten kunde inte hittas. Det kan bero på att posten inte längre är tillgänglig eller att du har råkat ange ett felaktigt id i adressfältet.
    4. Competition between Magnetic Structures in the Fe-Rich FCC FeNi Alloys
    Öppna denna publikation i ny flik eller fönster >>Competition between Magnetic Structures in the Fe-Rich FCC FeNi Alloys
    Visa övriga...
    2007 (Engelska)Ingår i: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 76, nr 1, s. 014434-Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    We report on the results of a systematic ab initio study of the magnetic structure of Fe rich fcc FeNi binary alloys for Ni concentrations up to 50 at. %. Calculations are carried out within density-functional theory using two complementary techniques, one based on the exact muffin-tin orbital theory within the coherent potential approximation and another one based on the projector augmented-wave method. We observe that the evolution of the magnetic structure of the alloy with increasing Ni concentration is determined by a competition between a large number of magnetic states, collinear as well as noncollinear, all close in energy. We emphasize a series of transitions between these magnetic structures, in particular we have investigated a competition between disordered local moment configurations, spin spiral states, the double layer antiferromagnetic state, and the ferromagnetic phase, as well as the ferrimagnetic phase with a single spin flipped with respect to all others. We show that the latter should be particularly important for the understanding of the magnetic structure of the Invar alloys.

    Ort, förlag, år, upplaga, sidor
    American Physical Society, 2007
    Nyckelord
    Iron alloys, nickel alloys, ferromagnetic materials, magnetic structure, ab initio calculations, density functional theory, linear muffin-tin orbital method, local moments
    Nationell ämneskategori
    Fysik
    Identifikatorer
    urn:nbn:se:liu:diva-14277 (URN)10.1103/PhysRevB.76.014434 (DOI)
    Anmärkning
    Original Publication: Igor A. Abrikosov, Andreas E. Kissavos, Francois Liot, Björn Alling, Sergey Simak, O. Peil and A. V. Ruban, Competition between Magnetic Structures in the Fe-Rich FCC FeNi Alloys, 2007, Physical Review B Condensed Matter, (76), 1, 014434. http://dx.doi.org/10.1103/PhysRevB.76.014434 Copyright: American Physical Society http://www.aps.org/Tillgänglig från: 2007-02-01 Skapad: 2007-02-01 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
    5. Questionable collapse of the bulk modulus in CrN
    Öppna denna publikation i ny flik eller fönster >>Questionable collapse of the bulk modulus in CrN
    2010 (Engelska)Ingår i: Nature Materials, ISSN 1476-1122, E-ISSN 1476-4660, Vol. 9, nr 4, s. 283-284Artikel i tidskrift, Letter (Övrigt vetenskapligt) Published
    Abstract [en]

    In this comment we show that the main conclusion in a previous article, claiminga drastic increase in compressibility of CrN at the cubic to orthorhombic phasetransition, is unsupported by first-principles calculations. We show that if thecubic CrN phase is considered as a disordered magnetic material, as supported bydifferent experimental data, rather then non-magnetic, the bulk modulus is almostunaffected by the transition.

    Ort, förlag, år, upplaga, sidor
    London, UK: Nature Publishing Group, 2010
    Nyckelord
    CrN, phase-transition, magnetism, bulk modulus, first-principles
    Nationell ämneskategori
    Den kondenserade materiens fysik
    Identifikatorer
    urn:nbn:se:liu:diva-60438 (URN)10.1038/nmat2722 (DOI)000275901000002 ()
    Tillgänglig från: 2010-10-13 Skapad: 2010-10-13 Senast uppdaterad: 2017-12-12Bibliografiskt granskad
    6. Effect of magnetic disorder and strong electron correlations on the thermodynamics of CrN
    Öppna denna publikation i ny flik eller fönster >>Effect of magnetic disorder and strong electron correlations on the thermodynamics of CrN
    2010 (Engelska)Ingår i: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 82, s. 184430-Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Two different methods for the modeling of a magnetically disordered CrN stateusing a supercell approach are investigated. They are found to give equivalentresults of the total energy, being also similar to results obtained with an effectivemedium approach. Furthermore, CrN is shown to be better described using aLDA+U framework for the treatment of electron-electron correlations as comparedto GGA or LDA calculations. Modeling the cubic paramagnetic phase with ourmodels for magnetic disorder and considering the strong electron correlations, thetemperature and pressure induced phase transitions in CrN can be explained.

    Ort, förlag, år, upplaga, sidor
    American institute of physics, 2010
    Nyckelord
    CrN, magnetic disorder, nitrides, LDA+U, SQS, phase transition, chromium compounds
    Nationell ämneskategori
    Naturvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-60439 (URN)10.1103/PhysRevB.82.184430 (DOI)000291462500005 ()
    Tillgänglig från: 2010-10-13 Skapad: 2010-10-13 Senast uppdaterad: 2017-12-12
    7. Theory of the ferromagnetism in Ti1-xCrxN solid solutions
    Öppna denna publikation i ny flik eller fönster >>Theory of the ferromagnetism in Ti1-xCrxN solid solutions
    2010 (Engelska)Ingår i: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 82, nr 5, s. 054408-Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    First-principles calculations are used to investigate the magnetic properties of Ti1‑xCrxN solid solutions. We show that the magnetic interactions between Cr spins that favor antiferromagnetism in CrN is changed upon alloying with TiN leading to the appearance of ferromagnetism in the system at approximately x≤0.50 in agreement with experimental reports. Furthermore we suggest that this effect originates in an electron density redistribution from Ti to Cr that decreases the polarization of Crd states with t2g symmetry while it increases the polarization of Crd states with eg symmetry, both changes working in favor of ferromagnetism.

    Nyckelord
    TiN, CrN, TiCrN, solid solutions, first-principles, magnetic interactions, ferromagnetism, electronic structure
    Nationell ämneskategori
    Den kondenserade materiens fysik
    Identifikatorer
    urn:nbn:se:liu:diva-60441 (URN)10.1103/PhysRevB.82.054408 (DOI)
    Anmärkning
    Original Publication: Björn Alling, Theory of the ferromagnetism in Ti1-xCrxN solid solutions, 2010, Physical Review B Condensed Matter, (82), 5, 054408. http://dx.doi.org/10.1103/PhysRevB.82.054408 Copyright: American Physical Society http://www.aps.org/Tillgänglig från: 2010-10-13 Skapad: 2010-10-13 Senast uppdaterad: 2017-12-12
    8. A unified cluster expansion method applied to the configurational thermodynamics of cubic TiAlN
    Öppna denna publikation i ny flik eller fönster >>A unified cluster expansion method applied to the configurational thermodynamics of cubic TiAlN
    Visa övriga...
    2011 (Engelska)Ingår i: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 83, nr 10, s. 104203-Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    We use a study of the cubic Ti1−xAlxN system to illustrate a practical way of combining the major methodologies within alloy theory, the Connolly-Williams cluster expansion and the generalized perturbation method, in order to solve difficult alloy problems. The configurational, concentration dependent, Hamiltonian is separated into a fixed-lattice and a local lattice relaxation part. The effective cluster interactions of the first part is obtained primarily with a GPM-based approach while the later is obtained using cluster expansion. In our case the impact on the isostructural phase diagram of considering short range clustering beyond the mean field approximation, obtained from the mixing enthalpy and entropy of the random alloy, is rather small, especially in the composition region x ≤ 0.66, within reach of thin film growth techniques.

    Ort, förlag, år, upplaga, sidor
    American Physical Society, 2011
    Nyckelord
    TiAlN, TiN, AlN, cluster expansion, GPM, spinodal decomposition, first-principles, titanium aluminium nitride, clustering, phase separation
    Nationell ämneskategori
    Naturvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-60442 (URN)10.1103/PhysRevB.83.104203 (DOI)000288782700004 ()
    Anmärkning
    Original Publication: Björn Alling, A. V. Ruban, A Karimi, Lars Hultman and Igor Abrikosov, A unified cluster expansion method applied to the configurational thermodynamics of cubic TiAlN, 2011, Physical Review B. Condensed Matter and Materials Physics, (83), 10, 104203. http://dx.doi.org/10.1103/PhysRevB.83.104203 Copyright: American Physical Society http://www.aps.org/ Tillgänglig från: 2010-10-13 Skapad: 2010-10-13 Senast uppdaterad: 2017-12-12
    9. Pressure enhancement of the isostructural cubic decomposition in Ti1−xAlxN
    Öppna denna publikation i ny flik eller fönster >>Pressure enhancement of the isostructural cubic decomposition in Ti1−xAlxN
    2009 (Engelska)Ingår i: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 95, nr 181906Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    The influence of pressure on the phase stabilities of Ti1−xAlxN solid solutions has been studied using first principles calculations. We find that the application of hydrostatic pressure enhances the tendency for isostructural decomposition, including spinodal decomposition. The effect originates in the gradual pressure stabilization of cubic AlN with respect to the wurtzite structure and an increased isostructural cubic mixing enthalpy with increased pressure. The influence is sufficiently strong in the composition-temperature interval corresponding to a shoulder of the spinodal line that it could impact the stability of the material at pressures achievable in the tool-work piece contact during cutting operations

    Nyckelord
    ab initio calculations, aluminium compounds, enthalpy, high-pressure effects, mixing, solid solutions, spinodal decomposition, titanium compounds
    Nationell ämneskategori
    Naturvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-51569 (URN)10.1063/1.3256196 (DOI)
    Anmärkning
    Original Publication: Björn Alling, Magnus Odén, Lars Hultman and Igor Abrikosov, Pressure enhancement of the isostructural cubic decomposition in Ti1-xAlxN, 2009, Applied Physics Letters, (95), 181906. http://dx.doi.org/10.1063/1.3256196 Copyright: American Institute of Physics http://www.aip.org/ Tillgänglig från: 2009-11-07 Skapad: 2009-11-07 Senast uppdaterad: 2017-12-12
    10. Effects of volume mismatch and electronic structure on the decomposition of ScAlN and TiAlN solid solutions
    Öppna denna publikation i ny flik eller fönster >>Effects of volume mismatch and electronic structure on the decomposition of ScAlN and TiAlN solid solutions
    Visa övriga...
    2010 (Engelska)Ingår i: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 81, nr 22, s. 224101-Artikel i tidskrift (Refereegranskat) Published
    Abstract [en]

    Thin solid films of metastable rocksalt structure (c-) Sc1-xAlxN and Ti1-xAlxN were employed as model systems to investigate the relative influence of volume mismatch and electronic structure driving forces for phase separation. Reactive dual magnetron sputtering was used to deposit stoichiometric Sc0.57Al0.43N(111) and Ti0.51Al0.49N(111) thin films, at 675 °C and 600 °C, respectively, followed by stepwise annealing to a maximum temperature of 1100 °C. Phase transformations during growth and annealing were followed in situ using X-ray scattering. The results show that the as-deposited Sc0.57Al0.43N films phase separate at 1000 °C – 1100 °C into non-isostructural c-ScN and wurtzite-structure (w-) AlN, via nucleation and growth at domain boundaries. Ti0.51Al0.49N, however, exhibits spinodal decomposition into isostructural coherent c-TiN and c-AlN, in the temperature interval of 800 °C – 1000 °C. X-ray pole figures show the coherency between c-ScN and w-AlN, with AlN(0001) || ScN(001) and AlN<01ɸ10> || ScN<1ɸ10>. First principles calculations of mixing energy-lattice spacing curves explain the results on a fundamental physics level and open a route for design of novel metastable pseudobinary phases for hard coatings and electronic materials.

    Nyckelord
    TiAlN, ScAlN, spinodal decomposition, nitrides, TiN, ScN, AlN, XRD, TEM, first-principles, phase separation, meta stable
    Nationell ämneskategori
    Naturvetenskap
    Identifikatorer
    urn:nbn:se:liu:diva-56270 (URN)10.1103/PhysRevB.81.224101 (DOI)000278300900004 ()
    Anmärkning
    Original Publication: Carina Höglund, Björn Alling, Jens Birch, Manfred Beckers, Per O. Å. Persson, Carsten Baehtz, Zsolt Czigány, Jens Jensen and Lars Hultman, Effects of volume mismatch and electronic structure on the decomposition of ScAlN and TiAlN solid solutions, 2010, Physical Review B. Condensed Matter and Materials Physics, (81), 22, 224101. http://dx.doi.org/10.1103/PhysRevB.81.224101 Copyright: American Physical Society http://www.aps.org/ Tillgänglig från: 2010-05-06 Skapad: 2010-05-06 Senast uppdaterad: 2017-12-12
    11.
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