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  • 451.
    Abrikosov, Igor
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics. Linköping University, Faculty of Science & Engineering. National University of Science and Technology MISIS, Russia.
    Ponomareva, A. V.
    National University of Science and Technology MISIS, Russia.
    Steneteg, Peter
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Barannikova, S. A.
    National University of Science and Technology MISIS, Russia; National Research Tomsk State University, Russia; SB RAS, Russia.
    Alling, Björn
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Recent progress in simulations of the paramagnetic state of magnetic materials2016In: Current opinion in solid state & materials science, ISSN 1359-0286, E-ISSN 1879-0348, Vol. 20, no 2, p. 85-106Article, review/survey (Refereed)
    Abstract [en]

    We review recent developments in the field of first-principles simulations of magnetic materials above the magnetic order disorder transition temperature, focusing mainly on 3d-transition metals, their alloys and compounds. We review theoretical tools, which allow for a description of a system with local moments, which survive, but become disordered in the paramagnetic state, focusing on their advantages and limitations. We discuss applications of these theories for calculations of thermodynamic and mechanical properties of paramagnetic materials. The presented examples include, among others, simulations of phase stability of Fe, Fe-Cr and Fe-Mn alloys, formation energies of vacancies, substitutional and interstitial impurities, as well as their interactions in Fe, calculations of equations of state and elastic moduli for 3d-transition metal alloys and compounds, like CrN and steels. The examples underline the need for a proper treatment of magnetic disorder in these systems. (C) 2015 Elsevier Ltd. All rights reserved.

  • 452.
    Abrikossova, Natalia
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
    Investigation of nanoparticle-cell interactions for development of next generation of biocompatible MRI contrast agents2018Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Progress in synthesis technologies and advances in fundamental understanding of materials with low dimensionality has led to the birth of a new scientific field, nanoscience, and to strong expectations of multiple applications of nanomaterials. The physical properties of small particles are unique, bridging the gap between atoms and molecules, on one side, and bulk materials on the other side. The work presented in this thesis investigates the potential of using magnetic nanoparticles as the next generation of contrast agents for biomedical imaging. The focus is on gadolinium-based nanoparticles and cellular activity including the uptake, morphology and production of reactive oxygen species.

    Gd ion complexes, like Gd chelates, are used today in the clinic, world-wide. However, there is a need for novel agents, with improved contrast capabilities and increased biocompatibility. One avenue in their design is based on crystalline nanoparticles. It allows to reduce the total number of Gd ions needed for an examination. This can be done by nanotechnology, which allows one to improve and fine tune the physico- chemical properties on the nanomaterial in use, and to increase the number of Gd atoms at a specific site that interact with protons and thereby locally increase the signal. In the present work, synthesis, purification and surface modification of crystalline Gd2O3-based nanoparticles have been performed. The nanoparticles are selected on the basis of their physical properties, that is they show enhanced magnetic properties and therefore may be of high potential interest for applications as contrast agents.

    The main synthesis method of Gd2O3 nanoparticles in this work was the modified “polyol” route, followed by purification of as-synthesized DEG-Gd2O3 nanoparticles suspensions. In most cases the purification step involved dialysis of the nanoparticle samples. In this thesis, organosilane were chosen as an exchange agent for further functionalization. Moreover, several paths have been explored for modification of the nanoparticles, including Tb3+ doping and capping with sorbitol.

    Biocompatibility of the newly designed nanoparticles is a prerequisite for their use in medical applications. Its evaluation is a complex process involving a wide range of biological phenomena. A promising path adopted in this work is to study of nanoparticle interactions with isolated blood cells. In this way one could screen nanomaterial prior to animal studies.

    The primary cell type considered in the thesis are polymorphonuclear neutrophils (PMN) which represent a type of the cells of human blood belonging to the granulocyte family of leukocytes. PMNs act as the first defense of the immune system against invading pathogens, which makes them valuable for studies of biocompatibility of newly synthesized nanoparticles. In addition, an immortalized murine alveolar macrophage cell line (MH-S), THP-1 cell line, and Ba/F3 murine bone marrow-derived cell line were considered to investigate the optimization of the cell uptake and to examine the potential of new intracellular contrast agent for magnetic resonance imaging.

    In paper I, the nanoparticles were investigated in a cellular system, as potential probes for visualization and targeting intended for bioimaging applications. The production of reactive oxygen species (ROS) by means of luminol-dependent chemiluminescence from human neutrophils was studied in presence of Gd2O3 nanoparticles. In paper II, a new design of functionalized ultra-small rare earth-based nanoparticles was reported. The synthesis was done using polyol method followed by PEGylation, and dialysis. Supersmall gadolinium oxide (DEG-Gd2O3) nanoparticles, in the range of 3-5 nm were obtained and carefully characterized. Neutrophil activation after exposure to this nanomaterial was studied by means of fluorescence microscopy. In paper III, cell labeling with Gd2O3 nanoparticles in hematopoietic cells was monitored by magnetic resonance imaging (MRI). In paper IV, ultra-small gadolinium oxide nanoparticles doped with terbium ions were synthesized as a potentially bifunctional material with both fluorescent and magnetic contrast agent properties. Paramagnetic behavior was studied. MRI contrast enhancement was received, and the luminescent/ fluorescent property of the particles was attributable to the Tb3+ ion located on the crystal lattice of the Gd2O3 host. Fluorescent labeling of living cells was obtained. In manuscript V, neutrophil granulocytes were investigated with rapid cell signaling communicative processes in time frame of minutes, and their response to cerium-oxide based nanoparticles were monitored using capacitive sensors based on Lab-on-a-chip technology. This showed the potential of label free method used to measure oxidative stress of neutrophil granulocytes. In manuscript VI, investigations of cell-(DEGGd2O3) nanoparticle interactions were carried out. Plain (DEG-Gd2O3) nanoparticles, (DEG-Gd2O3) nanoparticles in presence of sorbitol and (DEG-Gd2O3) nanoparticles capped with sorbitol were studied. Relaxation studies and measurements of the reactive oxygen species production by neutrophils were based on chemiluminescence. Cell morphology was evaluated as a parameter of the nanoparticle induced inflammatory response by means of the fluorescence microscopy.

    The thesis demonstrates high potential of novel Gd2O3-based nanoparticles for development of the next generation contrast agents, that is to find biocompatible compounds with high relaxivity that can be detected at lower doses, and in the future enable targeting to provide great local contrast.

    List of papers
    1. Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes
    Open this publication in new window or tab >>Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes
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    2012 (English)In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 23, no 27, p. 275101-Article in journal (Refereed) Published
    Abstract [en]

    We have previously shown that gadolinium oxide (Gd2O3) nanoparticles are promising candidates to be used as contrast agents in magnetic resonance (MR) imaging applications. In this study, these nanoparticles were investigated in a cellular system, as possible probes for visualization and targeting intended for bioimaging applications. We evaluated the impact of the presence of Gd2O3 nanoparticles on the production of reactive oxygen species (ROS) from human neutrophils, by means of luminol-dependent chemiluminescence. Three sets of Gd2O3 nanoparticles were studied, i.e. as synthesized, dialyzed and both PEG-functionalized and dialyzed Gd2O3 nanoparticles. In addition, neutrophil morphology was evaluated by fluorescent staining of the actin cytoskeleton and fluorescence microscopy. We show that surface modification of these nanoparticles with polyethylene glycol (PEG) is essential in order to increase their biocompatibility. We observed that the as synthesized nanoparticles markedly decreased the ROS production from neutrophils challenged with prey (opsonized yeast particles) compared to controls without nanoparticles. After functionalization and dialysis, more moderate inhibitory effects were observed at a corresponding concentration of gadolinium. At lower gadolinium concentration the response was similar to that of the control cells. We suggest that the diethylene glycol (DEG) present in the as synthesized nanoparticle preparation is responsible for the inhibitory effects on the neutrophil oxidative burst. Indeed, in the present study we also show that even a low concentration of DEG, 0.3%, severely inhibits neutrophil function. In summary, the low cellular response upon PEG-functionalized Gd2O3 nanoparticle exposure indicates that these nanoparticles are promising candidates for MR-imaging purposes.

    Place, publisher, year, edition, pages
    Institute of Physics, 2012
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-79667 (URN)10.1088/0957-4484/23/27/275101 (DOI)000305802000001 ()
    Available from: 2012-08-14 Created: 2012-08-13 Last updated: 2018-11-12
    2. Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement
    Open this publication in new window or tab >>Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement
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    2010 (English)In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 26, no 8, p. 5753-5762Article in journal (Refereed) Published
    Abstract [en]

    Recently, much attention has been given to the development of biofunctionalized nanoparticles with magnetic properties for novel biomedical imaging. Guided, smart, targeting nanoparticulate magnetic resonance imaging (MRI) contrast agents inducing high MRI signal will be valuable tools for future tissue specific imaging and investigation of molecular and cellular events. In this study, we report a new design of functionalized ultrasmall rare earth based nanoparticles to be used as a positive contrast agent in MRI. The relaxivity is compared to commercially available Gd based chelates. The synthesis, PEGylation, and dialysis of small (3−5 nm) gadolinium oxide (DEG-Gd2O3) nanoparticles are presented. The chemical and physical properties of the nanomaterial were investigated with Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, and dynamic light scattering. Neutrophil activation after exposure to this nanomaterial was studied by means of fluorescence microscopy. The proton relaxation times as a function of dialysis time and functionalization were measured at 1.5 T. A capping procedure introducing stabilizing properties was designed and verified, and the dialysis effects were evaluated. A higher proton relaxivity was obtained for as-synthesized diethylene glycol (DEG)-Gd2O3 nanoparticles compared to commercial Gd-DTPA. A slight decrease of the relaxivity for as-synthesized DEG-Gd2O3 nanoparticles as a function of dialysis time was observed. The results for functionalized nanoparticles showed a considerable relaxivity increase for particles dialyzed extensively with r1 and r2 values approximately 4 times the corresponding values for Gd-DTPA. The microscopy study showed that PEGylated nanoparticles do not activate neutrophils in contrast to uncapped Gd2O3. Finally, the nanoparticles are equipped with Rhodamine to show that our PEGylated nanoparticles are available for further coupling chemistry, and thus prepared for targeting purposes. The long term goal is to design a powerful, directed contrast agent for MRI examinations with specific targeting possibilities and with properties inducing local contrast, that is, an extremely high MR signal at the cellular and molecular level.

    Place, publisher, year, edition, pages
    American Chemical Society (ACS), 2010
    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:liu:diva-54946 (URN)10.1021/la903566y (DOI)000276562300061 ()
    Available from: 2010-04-23 Created: 2010-04-23 Last updated: 2018-10-29Bibliographically approved
    3. Gd2O3 nanoparticles in hematopoietic cells for MRI contrast enhancement
    Open this publication in new window or tab >>Gd2O3 nanoparticles in hematopoietic cells for MRI contrast enhancement
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    2011 (English)In: International journal of nano medicine, ISSN 1178-2013, Vol. 6, p. 3233-3240Article in journal (Refereed) Published
    Abstract [en]

    As the utility of magnetic resonance imaging (MRI) broadens, the importance of having specific and efficient contrast agents increases and in recent time there has been a huge development in the fields of molecular imaging and intracellular markers. Previous studies have shown that gadolinium oxide (Gd2O3) nanoparticles generate higher relaxivity than currently available Gd chelates: In addition, the Gd2O3 nanoparticles have promising properties for MRI cell tracking. The aim of the present work was to study cell labeling with Gd2O3 nanoparticles in hematopoietic cells and to improve techniques for monitoring hematopoietic stem cell migration by MRI. Particle uptake was studied in two cell lines: the hematopoietic progenitor cell line Ba/F3 and the monocytic cell line THP-1. Cells were incubated with Gd2O3 nanoparticles and it was investigated whether the transfection agent protamine sulfate increased the particle uptake. Treated cells were examined by electron microscopy and MRI, and analyzed for particle content by inductively coupled plasma sector field mass spectrometry. Results showed that particles were intracellular, however, sparsely in Ba/F3. The relaxation times were shortened with increasing particle concentration. Relaxivities, r1 and r2 at 1.5 T and 21°C, for Gd2O3 nanoparticles in different cell samples were 3.6–5.3 s-1 mM-1 and 9.6–17.2 s-1 mM-1, respectively. Protamine sulfate treatment increased the uptake in both Ba/F3 cells and THP-1 cells. However, the increased uptake did not increase the relaxation rate for THP-1 as for Ba/F3, probably due to aggregation and/or saturation effects. Viability of treated cells was not significantly decreased and thus, it was concluded that the use of Gd2O3 nanoparticles is suitable for this type of cell labeling by means of detecting and monitoring hematopoietic cells. In conclusion, Gd2O3 nanoparticles are a promising material to achieve positive intracellular MRI contrast; however, further particle development needs to be performed.

    Place, publisher, year, edition, pages
    Manchester, UK: Dove Medical Press Ltd, 2011
    Keywords
    gadolinium oxide, magnetic resonance imaging, contrast agent, cell labeling, Ba/F3 cells, THP-1 cells
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-72275 (URN)10.2147/IJN.S23940 (DOI)000298164300001 ()
    Note

    funding agencies|Swedish Research Council| 621-2007-3810 621-2009-5148 521-2009-3423 |VINNOVA| 2009-00194 |Center in Nanoscience and Technology at LiTH (CeNano)||

    Available from: 2011-11-24 Created: 2011-11-24 Last updated: 2018-10-29
    4. Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals: A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties
    Open this publication in new window or tab >>Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals: A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties
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    2009 (English)In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 113, no 17, p. 6913-6920Article in journal (Refereed) Published
    Abstract [en]

    Ultrasmall gadolinium oxide nanoparticles doped with terbium ions were synthesized by the polyol route and characterized as a potentially bifunctional material with both fluorescent and magnetic contrast agent properties. The structural, optical, and magnetic properties of the organic-acid-capped and PEGylated Gd2O3:Tb3+ nanocrystals were studied by HR-TEM, XPS, EDX, IR, PL, and SQUID. The luminescent/fluorescent property of the particles is attributable to the Tb3+ ion located on the crystal lattice of the Gd2O3 host. The paramagnetic behavior of the particles is discussed. Pilot studies investigating the capability of the nanoparticles for fluorescent labeling of living cells and as a MRI contrast agent were also performed. Cells of two cell lines (THP-1 cells and fibroblasts) were incubated with the particles, and intracellular particle distribution was visualized by confocal microscopy. The MRI relaxivity of the PEGylated nanoparticles in water at low Gd concentration was assessed showing a higher T-1 relaxation rate compared to conventional Gd-DTPA chelates and comparable to that of undoped Gd2O3 nanoparticles.

    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:liu:diva-12944 (URN)10.1021/jp808708m (DOI)000265529700009 ()
    Note

    On the day of the defence date the status of this article was Submitted

    Available from: 2008-02-21 Created: 2008-02-21 Last updated: 2018-10-29Bibliographically approved
  • 453.
    Abrikossova, Natalia
    Linköping University, The Department of Physics, Chemistry and Biology.
    In-vitro studier av inflammatorisk svar från helblod och neutrofila granulocyter vid aktivering med nanopartiklar2007Independent thesis Basic level (degree of Bachelor), 10 points / 15 hpStudent thesis
    Abstract [sv]

    Syftet med detta arbete var att studera inflammatoriska effekter i mänskligt helblod och neutrofila granulocyter exponerade och stimulerade av nanopartiklar av gadoliniumoxid. Projektet utreder den toxiska potentialen hos nanopartiklar med olika kemiska och morfologiska egenskaper.

    I experimenten undersöktes cellresponsen hos blodceller exponerade med ofunktionaliserade och funktionaliserade nanopartiklarna. Effekterna av funktionaliserade och ofunktionaliserade nanopartiklarna på aggregation och syreradikalproduktion i helblod och hos neutrofila granulocyter studerades med hjälp av lumi-aggregometri.

    Studier har visat att varken ofunktionaliserade eller funktionaliserade nanopartiklarna ger aggregation i blodet. Syreradikalproduktionen ökar däremot. Resultaten av studier i helblod visar att stimulering med spädnings serier av funktionaliserade nanopartiklar ger mindre frisättning av syreradikaler än spädnings serier med ofunktionaliserade nanopartiklar. Detta bekräftas med studier av morfologiska skillnader i neutrofila granulocyter som var stimulerade med olika typer av nanopartiklar. Detta gjordes med hjälp av fluorescensmikroskopi. Resultaten från studierna tyder på att funktionaliserade nanopartiklar är mindre inflammatoriska än ofunktionaliserade nanopartiklar.

  • 454.
    Abrikossova, Natalia
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
    Skoglund, Caroline
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, The Institute of Technology.
    Ahrén, Maria
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
    Bengtsson, Torbjorn
    University of Örebro, Sweden .
    Uvdal, Kajsa
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, Faculty of Science & Engineering.
    Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes2012In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 23, no 27, p. 275101-Article in journal (Refereed)
    Abstract [en]

    We have previously shown that gadolinium oxide (Gd2O3) nanoparticles are promising candidates to be used as contrast agents in magnetic resonance (MR) imaging applications. In this study, these nanoparticles were investigated in a cellular system, as possible probes for visualization and targeting intended for bioimaging applications. We evaluated the impact of the presence of Gd2O3 nanoparticles on the production of reactive oxygen species (ROS) from human neutrophils, by means of luminol-dependent chemiluminescence. Three sets of Gd2O3 nanoparticles were studied, i.e. as synthesized, dialyzed and both PEG-functionalized and dialyzed Gd2O3 nanoparticles. In addition, neutrophil morphology was evaluated by fluorescent staining of the actin cytoskeleton and fluorescence microscopy. We show that surface modification of these nanoparticles with polyethylene glycol (PEG) is essential in order to increase their biocompatibility. We observed that the as synthesized nanoparticles markedly decreased the ROS production from neutrophils challenged with prey (opsonized yeast particles) compared to controls without nanoparticles. After functionalization and dialysis, more moderate inhibitory effects were observed at a corresponding concentration of gadolinium. At lower gadolinium concentration the response was similar to that of the control cells. We suggest that the diethylene glycol (DEG) present in the as synthesized nanoparticle preparation is responsible for the inhibitory effects on the neutrophil oxidative burst. Indeed, in the present study we also show that even a low concentration of DEG, 0.3%, severely inhibits neutrophil function. In summary, the low cellular response upon PEG-functionalized Gd2O3 nanoparticle exposure indicates that these nanoparticles are promising candidates for MR-imaging purposes.

  • 455.
    Abring, Cecilia
    et al.
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Eriksson, Madeleine
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Transaktionsexponerade kassaflöden: En kvalitativ studie om hur styrdokument reglerar den praktiska hanteringen av transaktionsexponerade kassaflöden2015Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: As a result of increased international trading, adequate management of transaction exposure has become more important. Foreign currency cash flows are associated with different risks and thus give cause to distinct transaction exposure with overseas trading. Previous research advocates that management of transaction exposure is controlled through policy documents and we have identified a lack of research in how policy documents of Swedish firms are designed.

    Problem: To what extent is previous research agreeing with how Swedish firms have developed policy documents for managing transaction exposure of different foreign currency cash flows?

    Aim: The aim of the study is, compared to what previous research advocates, to examine and analyze how policy documents for managing transaction exposure are designed within the Swedish firms. The study also aims to analyze the differences in the policy document for the transaction exposure in different foreign currency cash flows, as well as the factors that give reasons to possible deviations.

    Conclusions: The findings of the study indicate a clear congruence between previous research and established practices of how policy documents for managing transaction exposure are designed in Swedish firms. Policy documents are comprehensive in their design; regulate the risk management strategy but not the management procedures. Even though the actual management of transaction exposure of different foreign currency cash flows indicates significant discrepancies, the policy document doesn’t regulate any of them. Giving reason for a different management are: factors related to the foreign exchange market characteristics, company-specific factors and other influencing market factors.Contribution: The study contributes to a better understanding and clearer differentiation of how Swedish firms control the management of transaction exposure, from a business perspective. Moreover, the study intends to give rise to the interest in how and on which grounds companies differently control the management of transaction exposure of different foreign currency cash flows.

  • 456.
    Abrishami, Mahdi
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Dynamic Link Flow Estimation according to Historical Travel Times2017Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Vast application of ITS and the availability of numerous on-road detection devices has resulted in variety of alternative data sources to be exploited and used in the field of traffic modelling. In this thesis, historical travel times, as an alternative data source, is employed on the developed method to perform dynamic network loading. The developed method, referred to as DNLTT, uses the share of each route available in the route choice set from the initial demand, as well as link travel times to perform the network loading. The output of the algorithm is time-dependent link flows. DNLTT is applied on Stockholm transportation network, where it is expected to have variation in link travel times in different time-periods, due to network congestion. In order to calculate the route shares, a time-sliced OD matrix is used. The historical travel times and the routes in the route choice set are extracted from an existing route planning tool. An available logit model, which considers the route travel time as the only logit parameter, is used for the route share calculation and the network loading is performed according to 2 different methods of DNLTT and DL. The evaluation of results is done for a toy network, where there happen different network states in different time-periods. Furthermore, the model output from Stockholm case study is analyzed and evaluated. The dynamic behavior of DNLTT is studied by analysis of link flows in different time-periods. Furthermore, the resulting link flows from both network loading methods are compared against observed link flows from radar sensors and the statistical analysis of link flows is performed accordingly. DNLTT exhibits a better performance on the toy network compared to DL, where the increasing link travel times cause the link flows to decline in different time-periods. However, the output of the developed method does not resemble the observed link flows for the investigated links in Stockholm case study. It is strongly believed, that the performance of DNLTT on the investigated transportation network potentially improves, in case the historical travel times better resemble the network dynamics. In addition to a more reliable data set, an OD adjustment process in all the time-periods is believed to generate better model output.

  • 457.
    Abrouk, Michael
    et al.
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Balcarkova, Barbora
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Simkova, Hana
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Kominkova, Eva
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Martis, Mihaela-Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Institute for Bioinformatics and Systems Biology, Helmholtz Center Munich, Neuherberg, Germany.
    Jakobson, Irena
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia.
    Timofejeva, Ljudmilla
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia.
    Rey, Elodie
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Vrana, Jan
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Kilian, Andrzej
    Diversity Arrays Technology Pty Ltd, Yarralumla, ACT2600, Australia.
    Järve, Kadri
    Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 19086, Estonia.
    Dolezel, Jaroslav
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    Valarik, Miroslav
    Institute of Experimental Botany, Centre of the Region Hana for Biotechnological and Agricultural Research, Olomouc, Czech Republic.
    The in silico identification and characterization of a bread wheat/Triticum militinae introgression line: Characterization of alien introgression in wheat2017In: Plant Biotechnology Journal, ISSN 1467-7644, E-ISSN 1467-7652, Vol. 15, no 2, p. 249-256Article in journal (Refereed)
    Abstract [en]

    The capacity of the bread wheat (Triticum aestivum) genome to tolerate introgression from related genomes can be exploited for wheat improvement. A resistance to powdery mildew expressed by a derivative of the cross bread wheat cv. Tähti ⨯ T. militinae (Tm) is known to be due to the incorporation of a Tm segment into the long arm of chromosome 4A. Here, a newly developed in silico method termed RICh (rearrangement identification and characterization) has been applied to characterize the introgression. A virtual gene order, assembled using the GenomeZipper approach, was obtained for the native copy of chromosome 4A; it incorporated 570 4A DArTseq markers to produce a zipper comprising 2,132 loci. A comparison between the native and introgressed forms of the 4AL chromosome arm showed that the introgressed region is located at the distal part of the arm. The Tm segment, derived from chromosome 7G, harbors 131 homoeologs out of the 357 genes present on the corresponding region of Chinese Spring 4AL. The estimated number of Tm genes transferred along with the disease resistance gene was 169. Characterizing the introgression's position, gene content and internal gene order should facilitate not only gene isolation, but may also be informative with respect to chromatin structure and behavior studies.

  • 458.
    Abtahi, Jahan
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Bisphosphonates and implants in the jaw bone2013Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Insertion of metal implants in bone is one of the commonest of all surgical procedures. The success of these operations is dependent on the fixation of the implants, which, in turn, depends on the strength of the bone that holds them. If the quality of the bone holding the implant could be improved locally, surgical procedures would become simpler and rehabilitation would become faster. Bisphosphonates are anti-resorptive drugs that act specifically on osteoclasts, thereby maintaining bone density and strength. Once released from the surface of a coated implant, bisphosphonates reduce osteoclast activity, thereby changing the balance of bone turnover in favor of bone formation, leading to a net gain in local bone density. During the last decades, the effects of bisphosphonate treatment on the stability of implants have been tested in several clinical and animal studies, but not in human jaws. This may be because it has been suggested that there is a link between the use of bisphosphonates (especially those given intravenously) and a condition called osteonecrosis of the jaw (ONJ). The pathophysiology and treatment of ONJ is controversial. The difficulty in treating ONJ has highlighted the importance of prevention.

    The overall aim of the present thesis was to evaluate the effect of local and systemic use of bisphosphonates on bone tissue. Could a thin, bisphosphonate-eluting fibrinogen coating improve the fixation of metal implants in the human jaw? Would it be possible to reproduce ONJ and prevent the development of this condition in an animal model?

    In two clinical studies, a total number of 96 implants were inserted in 21 patients. In a randomized trial with a paired design, one implant in each pair was coated with a thin fibrinogen layer containing two bisphosphonates (pamidronate and ibandronate). The bisphosphonate-coated implants showed better stability as measured by resonancefrequency analysis. Radiographic intraoral films also showed less bone loss. Three animal models were developed. In a study comparing local and systemic effects of bisphosphonates, zoledronate-coated screws inserted in rats showed better fixation in spite of a drug treatment that is known to induce ONJ-like lesions when given systemically. In another rat model, ONJ-like lesions were reproducibly induced at sites of tooth extraction whereas there were no signs of bone cell death in uninjured sites. Finally, rat experiments showed that the development of ONJ-like lesions after tooth extraction could be prevented by early mucoperiosteal coverage.

    In conclusion, a thin, bisphosphonate-eluting fibrinogen coating can improve the fixation of dental implants in human bone. This may lead to new possibilities in orthopaedic surgery and dentistry. The pathophysiology of ONJ is strongly linked to bone exposure in combination with drugs that reduce resorption.

    List of papers
    1. Bisphosphonate coating might improve fixation of dental implants in the maxilla: A pilot study
    Open this publication in new window or tab >>Bisphosphonate coating might improve fixation of dental implants in the maxilla: A pilot study
    2010 (English)In: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 39, no 7, p. 673-677Article in journal (Refereed) Published
    Abstract [en]

    This pilot study evaluates the clinical stability of bisphosphonate-coated dental implants placed using a two-stage surgical procedure in five patients. Each patient received seven regular Branemark implants, one of which was coated with bisphosphonate in a fibrinogen matrix. The coated implant was inserted where the bone was expected to have the least favourable quality. The level of the marginal bone around each implant was measured by intraoral periapical radiographs and implant stability was recorded using resonance frequency measurements. Frequency values (ISQ) were obtained peroperatively before flap closure and after 6 months at abutment connection. At abutment connection the bisphosphonate-coated implants were removed en bloc in two patients for histological examination. An animal experiment had previously confirmed that gamma-sterilization did not reduce bioactivity of the bisphosphonate coating. In each patient, the bisphosphonate-coated implant showed the largest improvement in ISQ level of all implants. Their values at the start tended to be lower, and the absolute value at 6 months did not differ. No complications occurred with the coated implants. Histology showed no abnormalities. Improvement in ISQ values was an expected effect of the bisphosphonate coating, but could be due to the choice of insertion site. This finding warrants a randomized blinded study.

    Place, publisher, year, edition, pages
    Elsevier Science B.V., Amsterdam, 2010
    Keywords
    bisphosphonate coating; dental implants; fixation
    National Category
    Orthopaedics Other Clinical Medicine
    Identifiers
    urn:nbn:se:liu:diva-58193 (URN)10.1016/j.ijom.2010.04.002 (DOI)000279972500007 ()
    Available from: 2010-08-11 Created: 2010-08-09 Last updated: 2018-01-12
    2. A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants
    Open this publication in new window or tab >>A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants
    2012 (English)In: Bone, ISSN 8756-3282, E-ISSN 1873-2763, Vol. 50, no 5, p. 1148-1151Article in journal (Refereed) Published
    Abstract [en]

    Many surgical procedures use metal implants in bone. The clinical results depend on the strength of the bone holding these implants. Our objective was to show that a drug released from the implant surface can improve parameters reflecting the quality or amount of this bone. Sixteen patients received paired dental titanium implants in the maxilla, in a randomized, double-blinded fashion. One implant in each pair was coated with a thin fibrinogen layer containing 2 bisphosphonates. The other implant was untreated. Fixation was evaluated by measurement of resonance frequency (implant stability quotient; ISQ) serving as a proxy for stiffness of the implant-bone construct. Increase in ISQ at 6 months of follow-up was the primary variable. None of the patients had any complications. The resonance frequency increased 6.9 ISQ units more for the coated implants (p = 0.0001; Cohens d = 1.3). The average difference in increase in ISQ and the effect size, suggested a clinically relevant improvement. X-ray showed less bone resorption at the margin of the implant both at 2 months (p = 0.012) and at 6 months (p = 0.012). In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. This might lead to new possibilities for orthopedic surgery in osteoporotic bone and for dental implants.

    Place, publisher, year, edition, pages
    Elsevier, 2012
    Keywords
    Bone healing, Dental implant, Drug delivery, Mechanical test, Osseointegration bisphosphonates
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-77527 (URN)10.1016/j.bone.2012.02.001 (DOI)000303274400018 ()
    Note

    Funding Agencies|Swedish Research Council|VR 2009-6725|

    Available from: 2012-05-28 Created: 2012-05-22 Last updated: 2017-12-07
    3. Bisphosphonate-induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone
    Open this publication in new window or tab >>Bisphosphonate-induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone
    2012 (English)In: Journal of Oral Pathology & Medicine, ISSN 0904-2512, E-ISSN 1600-0714, Vol. 41, no 6, p. 494-499Article in journal (Refereed) Published
    Abstract [en]

    J Oral Pathol Med (2012) 41: 494499 Background: Bisphosphonate-related osteonecrosis of the jaw was first described to start with sterile osteocyte death, similar to osteonecrosis in other parts of the skeleton. The typical chronic osteomyelitis was thought to develop when the dead bone was exposed to the oral cavity. An alternative explanation would be that the chronic osteomyelitis is a result of a bisphosphonate-related inability of infected bony lesions to heal. We tested the hypothesis that primary osteocyte death is not necessary for the development of jaw osteonecrosis. Material and methods: Forty rats were randomly allocated to four groups of 10. All animals underwent unilateral molar extraction and received the following drug treatments: Group I, controls with no drug treatment; Group II, 200 mu g/kg per day alendronate; Groups III and IV, 200 mu g/kg per day alendronate and 1 mg/kg of dexamethasone. All rats were euthanized after 14 days. Presence of osteonecrosis was determined by clinical and histological observations for groups IIII. For group IV, osteocyte viability at the contralateral uninjured site was examined using lactate dehydrogenase histochemistry (LDH). Results: All animals in the alendronate plus dexamethasone groups developed large ONJ-like lesions. Lactate dehydrogenase staining showed viable osteocytes in the contralateral jaw with no tooth extraction. No signs of osteonecosis were seen in the other groups. Conclusion: Bisphosphonates and dexamethasone caused no osteocyte death in uninjured bone, but large ONJ-like lesions after tooth extraction. Osteonecrosis of the jaw appears to arise first after the bone has been exposed. Possibly, bisphosphonates hamper the necessary resorption of bone that has become altered because of infection.

    Place, publisher, year, edition, pages
    John Wiley and Sons, 2012
    Keywords
    bisphosphonates; bisphosphonate associated osteonecrosis of the jaw; osteonecrosis; rat
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-79679 (URN)10.1111/j.1600-0714.2011.01125.x (DOI)000305961100010 ()
    Available from: 2012-08-14 Created: 2012-08-13 Last updated: 2017-12-07
    4. Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw
    Open this publication in new window or tab >>Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw
    2013 (English)In: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 92, no 3, p. 279-283Article in journal (Refereed) Published
    Abstract [en]

    Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without complications in a setting where systemic treatment induces ONJ. Forty rats were randomly allocated to 4 groups of 10. All groups received a titanium implant inserted in an extraction socket. Group I received the implants only. Group II received dexamethasone (0.5 mg/kg). Group III received dexamethasone as above plus alendronate (200 µg/kg). Group IV received zoledronate-coated implants and dexamethasone as above. The animals were sacrificed 2 weeks after tooth extraction. All 10 animals with systemic alendronate treatment developed large ONJ-like changes, while all with local treatment were completely healed. Implant removal torque was higher for the bisphosphonate-coated implants compared with the other groups (p < 0.03 for each comparison). Micro-computed tomography of the maxilla showed more bone loss in the systemic alendronate group compared with groups receiving local treatment (p = 0.001). Local bisphosphonate treatment appears to improve implant fixation in a setting where systemic treatment caused ONJ.

    Place, publisher, year, edition, pages
    Sage Publications, 2013
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-89667 (URN)10.1177/0022034512472335 (DOI)000314914100013 ()23264610 (PubMedID)
    Available from: 2013-03-01 Created: 2013-03-01 Last updated: 2017-12-06Bibliographically approved
    5. Prevention of osteonecrosis of the jaw by mucoperiosteal coverage in a rat model
    Open this publication in new window or tab >>Prevention of osteonecrosis of the jaw by mucoperiosteal coverage in a rat model
    2013 (English)In: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 42, no 5, p. 632-636Article in journal (Refereed) Published
    Abstract [en]

    There is evidence for a link between the use of systemic bisphosphonates and osteonecrosis of the jaw (ONJ). This condition has the appearance of chronic osteomyelitis, and antibiotics prevent the development of ONJ in animal models. Clinically, ONJ can sometimes be successfully treated by mucoperiosteal coverage. If ONJ is indeed primarily caused by bacterial infection, immediate coverage of the extraction alveolus might reduce the risk of ONJ development in risk patients. Therefore, we studied whether immediate mucoperiosteal coverage after tooth extraction could prevent ONJ development in a rat model. Thirty rats were randomly allocated to three groups of 10. Group I (controls): extraction, no drug treatment; Group II (non-coverage): extraction, dexamethasone plus alendronate; Group III (coverage): dexamethasone plus alendronate, plus coverage by a mucoperiosteal flap. Rats were examined for macroscopic ONJ-like wounds after 2 weeks. All animals in the non-coverage group developed large ONJ-like changes. The coverage and control groups showed an intact overlying mucosa in all rats. Findings were confirmed with histology. Bisphosphonates and dexamethasone caused ONJ-like lesions after tooth extraction in a rat model. This was prevented by immediate mucoperiosteal coverage. The risk of ONJ in patients using bisphosphonates might be reduced by mucoperiosteal coverage after tooth extraction.

    Keywords
    Bisphosphonates, osteonecrosis, jaw, rat, mucoperiosteal flap, antibiotics
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-89668 (URN)10.1016/j.ijom.2013.02.007 (DOI)000318132600014 ()
    Available from: 2013-03-01 Created: 2013-03-01 Last updated: 2017-12-06Bibliographically approved
  • 459.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Agholme, Fredrik
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
    Aspenberg, Per
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Prevention of osteonecrosis of the jaw by mucoperiosteal coverage in a rat model2013In: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 42, no 5, p. 632-636Article in journal (Refereed)
    Abstract [en]

    There is evidence for a link between the use of systemic bisphosphonates and osteonecrosis of the jaw (ONJ). This condition has the appearance of chronic osteomyelitis, and antibiotics prevent the development of ONJ in animal models. Clinically, ONJ can sometimes be successfully treated by mucoperiosteal coverage. If ONJ is indeed primarily caused by bacterial infection, immediate coverage of the extraction alveolus might reduce the risk of ONJ development in risk patients. Therefore, we studied whether immediate mucoperiosteal coverage after tooth extraction could prevent ONJ development in a rat model. Thirty rats were randomly allocated to three groups of 10. Group I (controls): extraction, no drug treatment; Group II (non-coverage): extraction, dexamethasone plus alendronate; Group III (coverage): dexamethasone plus alendronate, plus coverage by a mucoperiosteal flap. Rats were examined for macroscopic ONJ-like wounds after 2 weeks. All animals in the non-coverage group developed large ONJ-like changes. The coverage and control groups showed an intact overlying mucosa in all rats. Findings were confirmed with histology. Bisphosphonates and dexamethasone caused ONJ-like lesions after tooth extraction in a rat model. This was prevented by immediate mucoperiosteal coverage. The risk of ONJ in patients using bisphosphonates might be reduced by mucoperiosteal coverage after tooth extraction.

  • 460.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Agholme, Fredrik
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
    Sandberg, Olof
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Aspenberg, Per
    Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping. Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
    Bisphosphonate-induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone2012In: Journal of Oral Pathology & Medicine, ISSN 0904-2512, E-ISSN 1600-0714, Vol. 41, no 6, p. 494-499Article in journal (Refereed)
    Abstract [en]

    J Oral Pathol Med (2012) 41: 494499 Background: Bisphosphonate-related osteonecrosis of the jaw was first described to start with sterile osteocyte death, similar to osteonecrosis in other parts of the skeleton. The typical chronic osteomyelitis was thought to develop when the dead bone was exposed to the oral cavity. An alternative explanation would be that the chronic osteomyelitis is a result of a bisphosphonate-related inability of infected bony lesions to heal. We tested the hypothesis that primary osteocyte death is not necessary for the development of jaw osteonecrosis. Material and methods: Forty rats were randomly allocated to four groups of 10. All animals underwent unilateral molar extraction and received the following drug treatments: Group I, controls with no drug treatment; Group II, 200 mu g/kg per day alendronate; Groups III and IV, 200 mu g/kg per day alendronate and 1 mg/kg of dexamethasone. All rats were euthanized after 14 days. Presence of osteonecrosis was determined by clinical and histological observations for groups IIII. For group IV, osteocyte viability at the contralateral uninjured site was examined using lactate dehydrogenase histochemistry (LDH). Results: All animals in the alendronate plus dexamethasone groups developed large ONJ-like lesions. Lactate dehydrogenase staining showed viable osteocytes in the contralateral jaw with no tooth extraction. No signs of osteonecosis were seen in the other groups. Conclusion: Bisphosphonates and dexamethasone caused no osteocyte death in uninjured bone, but large ONJ-like lesions after tooth extraction. Osteonecrosis of the jaw appears to arise first after the bone has been exposed. Possibly, bisphosphonates hamper the necessary resorption of bone that has become altered because of infection.

  • 461.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Agholme, Fredrik
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
    Sandberg, Olof
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
    Aspenberg, Per
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw2013In: Journal of Dental Research, ISSN 0022-0345, E-ISSN 1544-0591, Vol. 92, no 3, p. 279-283Article in journal (Refereed)
    Abstract [en]

    Locally applied bisphosphonates may improve the fixation of metal implants in bone. However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of the jaw (ONJ). We hypothesized that local delivery of bisphosphonate from the implant surface improves the fixation of dental implants without complications in a setting where systemic treatment induces ONJ. Forty rats were randomly allocated to 4 groups of 10. All groups received a titanium implant inserted in an extraction socket. Group I received the implants only. Group II received dexamethasone (0.5 mg/kg). Group III received dexamethasone as above plus alendronate (200 µg/kg). Group IV received zoledronate-coated implants and dexamethasone as above. The animals were sacrificed 2 weeks after tooth extraction. All 10 animals with systemic alendronate treatment developed large ONJ-like changes, while all with local treatment were completely healed. Implant removal torque was higher for the bisphosphonate-coated implants compared with the other groups (p < 0.03 for each comparison). Micro-computed tomography of the maxilla showed more bone loss in the systemic alendronate group compared with groups receiving local treatment (p = 0.001). Local bisphosphonate treatment appears to improve implant fixation in a setting where systemic treatment caused ONJ.

  • 462.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Ajan, Aida
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Malignant Transformation of Ossifying Fibroma into Parosteal Osteosarcoma with High-grade Component: Presentation of an Unusual Case and Review of the Literature2018In: The Open Dentistry Journal, E-ISSN 1874-2106, Vol. 12, p. 1059-1068Article in journal (Refereed)
    Abstract [en]

    Background: Parosteal Osteosarcoma of the Jaw (POSJ) is a rare entity that is associated with a high survival rate. Several case reports and case series of POSJ have been published in the literature, but few authors have described development of this tumor by possible transformation from a fibro-osseous neoplasm. Objective: We present a rare occurrence of parosteal osteosarcoma with involvement of the posterior maxilla, orbit floor, and infra-temporal fossa in a 20-year-old man. Furthermore, we performed a literature review regarding clinical, radiological, and histological features; treatment strategies; and etiology/pathophysiology. Methods: A PubMed search yielded a total of 74 articles and the articles were sorted according to their corresponding key area of focus. Results: This was a case of POSJ with high-grade component in the maxillofacial region of a 20-year old male. Co-expression of MDM2 and CDK4 was confirmed. At 2.5-year follow-up, the patient had died. The literature review revealed 18 articles including 20 cases of POSJ. Four cases represent the possible development of this tumor by transformation from a fibro-osseous neoplasm: Two cases of fibrous dysplasia, one case of cemento-ossifying fibroma, and the case of Ossifying Fibroma (OF) in the present study. Conclusion: In conclusion, we found an unusual case of POSJ of the midface in a patient with a previous diagnosis of OF in the same region. To our knowledge, there have been no previous reports of development of POSJ in OF. Furthermore, this is the first described case of high-grade surface osteosarcoma in the craniofacial region.

  • 463.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Henefalk, G.
    Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Aspenberg, Per
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Randomised trial of bisphosphonate-coated dental implants: Radiographic follow-up after five years of loading2016In: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 45, no 12, p. 1564-1569Article in journal (Refereed)
    Abstract [en]

    The results of a randomised trial with bisphosphonate-coated dental implants have been reported previously. Each patient received one coated and one uncoated implant in a double-blind split-mouth design study. After 6 months of osseointegration, resonance frequency analysis indicated better fixation of the coated implants. Reduced marginal bone resorption was also shown. However, it was not known whether the advantage of the bisphosphonate coating would persist over time. The radiographic results at 5 years after implant installation are reported herein. A blinded investigator measured marginal resorption on fresh radiographs obtained for 14 of the 16 patients (two had died) and compared these with the post-implantation images. Non-parametric statistics were used. All implants functioned well. The median marginal bone loss for control implants was found to be 0.70 mm, which is less than usually reported in the literature. The bisphosphonate-coated implants showed even less resorption (median 0.20 mm). The median difference within each pair of implants after 5 years of use was 0.34 mm (95% confidence interval 0.00-0.75 mm; P = 0.04). The present data suggest that bisphosphonate-coated implants enable prolonged preservation of the marginal bone.

  • 464.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Henefalk, Gustav
    Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Aspenberg, Per
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Impact of a zoledronate coating on early post-surgical implant stability and marginal bone resorption in the maxilla-A split-mouth randomized clinical trial.2019In: Clinical Oral Implants Research, ISSN 0905-7161, E-ISSN 1600-0501, Vol. 30, no 1, p. 49-58Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: The objective of this clinical study was to evaluate the effect of a bisphosphonate coating on a titanium implant on the implant stability quotient (ISQ) and the radiographic marginal bone levels at implants during early healing (2-8 weeks).

    MATERIALS AND METHODS: In a randomized double-blind trial with internal controls, 16 patients received a dental implant coated with zoledronate and one uncoated implant as a control. The coated and uncoated implants which were visually indistinguishable were bone level titanium implants with a moderately rough surface and a microthreaded neck. ISQ values were obtained at insertion and at 2, 4, 6, and 8 weeks. Radiographs were obtained at insertion and at 8 weeks. The primary outcome was the difference in ISQ values between the coated implants and the control implants at 4 and 6 weeks, corrected for insertion values. The secondary outcome was loss of marginal bone level from insertion to 8 weeks.

    RESULTS: Implant stability quotient values remained largely constant over the 8 weeks, and there was no significant difference between coated and uncoated implants at any time point. There was 0.12 (SD 0.10) mm marginal bone loss at the control implants and 0.04 (SD 0.08) mm at the coated implants. The difference was 0.17 mm; SD 0.14; p < 0.006). On blind qualitative scoring, 13 of the 15 control implants and two of 15 coated implants showed small marginal bone defects (p = 0.003).

    CONCLUSIONS: There were no statistically significant differences observed in ISQ values between the coated and uncoated implants during the early healing. There was less marginal bone loss at the coated implants.

  • 465.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Malakuti, Iman
    Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Ajan, Aida
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Surgical Management of Granular Cell Tumor of the Orbit: Case Report and Literature Review2019In: Open Dentistry Journal, ISSN 1874-2106, E-ISSN 1874-2106, Vol. 13, p. 33-40Article in journal (Refereed)
    Abstract [en]

    Introduction: Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the literature. The treatment of the choice is total excision. Early diagnosis prior to surgery is valuable for the distinction of malignant from benign tumor.

    Case presentation: We report a case of a 55-year-old woman with a solitary slow-growing mass in the right orbit with the involvement of the rectus inferior muscle, and present a review of the recent literature. The lesion had a diameter of 1 cm and was noticed 2 years before the examination. Excisional biopsy confirmed the diagnosis of GCT. The tumor was resected through a retroseptal transconjunctival approach. The final histological examination revealed findings characteristic of GCT, including positive reaction for protein S-100, SOX10, and calcitonin and negative reaction for desmin, myogenin, Smooth Muscle Antigen (SMA), Melan-A, and HMB-45. There were no signs of malignancy in this sample. Disturbance of motility was not noted by the patient after surgery.

    Conclusion: GCT should be included in the differential diagnosis of intraorbital lesions, particularly those that involve the orbit muscles. A biopsy is recommended before surgical resection, to exclude malignancy and prevent radical resection.

  • 466.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Anaesthetics, Operations and Specialty Surgery Center, Maxillofacial Unit.
    Tengvall, Pentti
    Gothenburg University.
    Aspenberg, Per
    Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping. Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics. Linköping University, Faculty of Health Sciences.
    A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants2012In: Bone, ISSN 8756-3282, E-ISSN 1873-2763, Vol. 50, no 5, p. 1148-1151Article in journal (Refereed)
    Abstract [en]

    Many surgical procedures use metal implants in bone. The clinical results depend on the strength of the bone holding these implants. Our objective was to show that a drug released from the implant surface can improve parameters reflecting the quality or amount of this bone. Sixteen patients received paired dental titanium implants in the maxilla, in a randomized, double-blinded fashion. One implant in each pair was coated with a thin fibrinogen layer containing 2 bisphosphonates. The other implant was untreated. Fixation was evaluated by measurement of resonance frequency (implant stability quotient; ISQ) serving as a proxy for stiffness of the implant-bone construct. Increase in ISQ at 6 months of follow-up was the primary variable. None of the patients had any complications. The resonance frequency increased 6.9 ISQ units more for the coated implants (p = 0.0001; Cohens d = 1.3). The average difference in increase in ISQ and the effect size, suggested a clinically relevant improvement. X-ray showed less bone resorption at the margin of the implant both at 2 months (p = 0.012) and at 6 months (p = 0.012). In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. This might lead to new possibilities for orthopedic surgery in osteoporotic bone and for dental implants.

  • 467.
    Abtahi, Jahan
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences.
    Tengvall, Pentti
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology. Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden.
    Aspenberg, Per
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    Bisphosphonate coating might improve fixation of dental implants in the maxilla: A pilot study2010In: International Journal of Oral and Maxillofacial Surgery, ISSN 0901-5027, E-ISSN 1399-0020, Vol. 39, no 7, p. 673-677Article in journal (Refereed)
    Abstract [en]

    This pilot study evaluates the clinical stability of bisphosphonate-coated dental implants placed using a two-stage surgical procedure in five patients. Each patient received seven regular Branemark implants, one of which was coated with bisphosphonate in a fibrinogen matrix. The coated implant was inserted where the bone was expected to have the least favourable quality. The level of the marginal bone around each implant was measured by intraoral periapical radiographs and implant stability was recorded using resonance frequency measurements. Frequency values (ISQ) were obtained peroperatively before flap closure and after 6 months at abutment connection. At abutment connection the bisphosphonate-coated implants were removed en bloc in two patients for histological examination. An animal experiment had previously confirmed that gamma-sterilization did not reduce bioactivity of the bisphosphonate coating. In each patient, the bisphosphonate-coated implant showed the largest improvement in ISQ level of all implants. Their values at the start tended to be lower, and the absolute value at 6 months did not differ. No complications occurred with the coated implants. Histology showed no abnormalities. Improvement in ISQ values was an expected effect of the bisphosphonate coating, but could be due to the choice of insertion site. This finding warrants a randomized blinded study.

  • 468.
    Abu Baker, Mohamed
    Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory.
    Agile Prototyping: A combination of different approaches into one main process2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Software prototyping is considered to be one of the most important tools that are used by software engineersnowadays to be able to understand the customer’s requirements, and develop software products that are efficient,reliable, and acceptable economically. Software engineers can choose any of the available prototyping approaches tobe used, based on the software that they intend to develop and how fast they would like to go during the softwaredevelopment. But generally speaking all prototyping approaches are aimed to help the engineers to understand thecustomer’s true needs, examine different software solutions and quality aspect, verification activities…etc, that mightaffect the quality of the software underdevelopment, as well as avoiding any potential development risks.A combination of several prototyping approaches, and brainstorming techniques which have fulfilled the aim of theknowledge extraction approach, have resulted in developing a prototyping approach that the engineers will use todevelop one and only one throwaway prototype to extract more knowledge than expected, in order to improve thequality of the software underdevelopment by spending more time studying it from different points of view.The knowledge extraction approach, then, was applied to the developed prototyping approach in which thedeveloped model was treated as software prototype, in order to gain more knowledge out of it. This activity hasresulted in several points of view, and improvements that were implemented to the developed model and as a resultAgile Prototyping AP, was developed. AP integrated more development approaches to the first developedprototyping model, such as: agile, documentation, software configuration management, and fractional factorialdesign, in which the main aim of developing one, and only one prototype, to help the engineers gaining moreknowledge, and reducing effort, time, and cost of development was accomplished but still developing softwareproducts with satisfying quality is done by developing an evolutionary prototyping and building throwawayprototypes on top of it.

  • 469.
    Abu Syeed, Kazi
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    A GIS based Site Suitability Analysis for Shrimp Cultivation in the Coastal Region of Bangladesh2007Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Bangladesh geographically comprised one of the largest delta landscapes of the world. Almost 6.7% of country’stotal area (147570 sqkm.) is covered byrivers and inland water bodies. These water bodies being rich in fishproduction meet the majority of the demand of protein. Bangladesh produces world's fourth largest quantity of fishand it is collected from the inland water bodies. Though shrimps were easily available in the inland water bodies forhundreds of years but shrimp culture as an export-oriented activity is a phenomenon of recent past. Bangladeshearned US$ 2.9 million by exporting shrimp in 1972-73 which was 1 % of the country's total exports. It increased to US$ 33 million in 1980 and to US$ 90.0 million in 1985. But until the mid-1980’s shrimp culture was principallydependent on open-water catches of shrimp it means that time shrimps were not cultivated in a proper planned way.But the culture of shrimp totally for export purpose started after the mid 1980’s. Since then the professional cultivation of shrimp had a very positive and effective impact on the economy of Bangladesh. Exports of shrimpfrom Bangladesh increased from US$ 91 million in FY (Fiscal Year) 1986 to US$ 280 million in FY1997. Duringthe corresponding period, the quantity of shrimp exports increased from 17.2 thousand tonnes to 25.2 thousandtonnes. As most of the shrimp farms have been developed without considering the sustainability of the environmentand some other factors like water pH & salinity, soil pH & salinity, soil texture etc. the farmers are getting lessreturn but affecting the environment most. Geographical Information System (GIS) can give an easier but effectivesolution here through selecting the best suitable sites for shrimp cultivation. Moreover GIS can solve thetransportation problem of this perishable product from the production area to the harbor or airport through transport route selection. This cansave a lot of money and time and consequently make the shrimp cultivation moreeconomic.

  • 470. Abu-Elyazeed, R R
    et al.
    Heineman, T
    Dubin, G
    Fourneau, M
    Leroux-Roels, I
    Leroux-Roels, G
    Richardus, J H
    Ostergaard, L
    Diez-Domingo, J
    Poder, A
    Van Damme, P
    Romanowski, B
    Blatter, M
    Silfverdal, S A
    Berglund, J
    Josefsson, Ann
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Cunningham, A L
    Flodmark, C E
    Tragiannidis, A
    Dobson, S
    Olafsson, J
    Puig-Barbera, J
    Mendez, M
    Barton, S
    Bernstein, D
    Mares, J
    Ratner, P
    Safety and immunogenicity of a glycoprotein D genital herpes vaccine in healthy girls 10-17 years of age: results from a randomised, controlled, double-blind trial.2013In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 31, no 51, p. 6136-6043Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The investigational AS04-adjuvanted herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit prophylactic vaccine ('HSV vaccine'; GlaxoSmithKline Vaccines) has been shown to be well tolerated in adults, but limited data exist for pre-teen and adolescent girls, a likely target population. The primary objective of this study was to compare the occurrence of serious adverse events (SAEs) over 12 months between HSV vaccine recipients and saline recipients (placebo control group) in pre-teen and adolescent girls. The immunogenicity of the HSV vaccine was also assessed.

    METHODS: Healthy girls aged 10-17 years, stratified by age (10-15 years; 16-17 years), were randomised 2:1:1 to receive the HSV vaccine, a hepatitis A vaccine (Havrix™; HAV control) or placebo (saline) according to a 0-, 1-, 6-month schedule. Participants and study personnel not involved in the preparation or administration of vaccines were blinded to treatment. Safety and immunogenicity analyses were performed overall and by age (10-15 years; 16-17 years) and HSV serostatus.

    RESULTS: No statistically significant difference in the percentage of subjects with SAEs was observed between the HSV and saline group, or between the HSV and pooled control (HAV and saline) groups. The HSV vaccine was well tolerated, although a higher incidence of solicited local symptoms was observed in the HSV group than in the control group. Neither age nor HSV serostatus at the time of study entry had an impact on the safety profile of this vaccine. The HSV vaccine was immunogenic regardless of pre-vaccination HSV serostatus. Higher anti-gD geometric mean concentrations were observed in HSV-1 seropositive participants than in HSV-1 seronegative participants.

    CONCLUSION: The HSV vaccine had an acceptable safety profile, and was well tolerated and immunogenic when administered to girls aged 10-17 years regardless of age or HSV pre-vaccination serostatus.

  • 471.
    Abugessaisa, Imad
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Analytical tools and information-sharing methods supporting road safety organizations2008Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    A prerequisite for improving road safety are reliable and consistent sources of information about traffic and accidents, which will help assess the prevailing situation and give a good indication of their severity. In many countries there is under-reporting of road accidents, deaths and injuries, no collection of data at all, or low quality of information. Potential knowledge is hidden, due to the large accumulation of traffic and accident data. This limits the investigative tasks of road safety experts and thus decreases the utilization of databases. All these factors can have serious effects on the analysis of the road safety situation, as well as on the results of the analyses.

    This dissertation presents a three-tiered conceptual model to support the sharing of road safety–related information and a set of applications and analysis tools. The overall aim of the research is to build and maintain an information-sharing platform, and to construct mechanisms that can support road safety professionals and researchers in their efforts to prevent road accidents. GLOBESAFE is a platform for information sharing among road safety organizations in different countries developed during this research.

    Several approaches were used, First, requirement elicitation methods were used to identify the exact requirements of the platform. This helped in developing a conceptual model, a common vocabulary, a set of applications, and various access modes to the system. The implementation of the requirements was based on iterative prototyping. Usability methods were introduced to evaluate the users’ interaction satisfaction with the system and the various tools. Second, a system-thinking approach and a technology acceptance model were used in the study of the Swedish traffic data acquisition system. Finally, visual data mining methods were introduced as a novel approach to discovering hidden knowledge and relationships in road traffic and accident databases. The results from these studies have been reported in several scientific articles.

    List of papers
    1. Ontological Approach to Modeling Information Systems
    Open this publication in new window or tab >>Ontological Approach to Modeling Information Systems
    2004 (English)In: Proceedings of the Fourth International Conference on Computer and information Technology (Cit'04), 14–16 September, Wuhan, China: IEEE Computer Society, Washington, DC, 2004, p. 1122-1127Conference paper, Published paper (Other academic)
    Abstract [en]

    In recent years, the use of formal tools in information system modeling and development represents a potential area of research in computer science. In 1967, the term ontology appeared for the first time in computer science literature as S. H. Mealy introduced it as a basic foundation in data modeling. The main objective of this paper is to discuss the concept of ontology (from a philosophical perspective) as it was used to bridge the gap between philosophy and information systems science, and to investigate ontology types that can be found during ontological investigation and the methods used in the investigation process. The secondary objective of this paper is to study different design and engineering approaches of ontology as well as development environments that are used to create and edit ontologies.

    Keywords
    Ontology, Conceptual Model
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13184 (URN)10.1109/CIT.2004.1357345 (DOI)
    Available from: 2008-04-28 Created: 2008-04-28 Last updated: 2009-04-21
    2. Benchmarking Road Safety Situations Using OGC Model of Portrayal Workflow
    Open this publication in new window or tab >>Benchmarking Road Safety Situations Using OGC Model of Portrayal Workflow
    2005 (English)In: Proceedings of the 13th International Conference on Geoinformatics (GeoInformatics’5), 17-19 August, Toronto, Canada: Ryerson University, 2005Conference paper, Published paper (Other academic)
    Keywords
    road safety, benchmarking, OGC model
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13185 (URN)
    Available from: 2008-04-28 Created: 2008-04-28 Last updated: 2009-04-21
    3. Map as Interface for Shared Information: A Study of Design Principles and User Interaction Satisfaction
    Open this publication in new window or tab >>Map as Interface for Shared Information: A Study of Design Principles and User Interaction Satisfaction
    2006 (English)In: IADIS International Conference WWW/Internet 2006: Murcia, Spain, 2006, p. 377-384Conference paper, Published paper (Refereed)
    Keywords
    Maps, shared information, design priciples, user satisfaction
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13186 (URN)972-8924-19-4 (ISBN)
    Available from: 2008-04-28 Created: 2008-04-28 Last updated: 2009-02-05Bibliographically approved
    4. GLOBESAFE: A Platform for Information-Sharing Among Road Safety Organizations
    Open this publication in new window or tab >>GLOBESAFE: A Platform for Information-Sharing Among Road Safety Organizations
    2007 (English)In: IFIP-W.G. 9th International Conference on Social Implications of Computers in Developing Countries: May 2007, São Paulo, Brazil, 2007, p. 1-10Conference paper, Published paper (Refereed)
    Keywords
    information sharing, road safety
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13187 (URN)
    Available from: 2008-04-28 Created: 2008-04-28 Last updated: 2009-04-23Bibliographically approved
    5. A Systemic View on Swedish Traffic Accident Data Acquisition System
    Open this publication in new window or tab >>A Systemic View on Swedish Traffic Accident Data Acquisition System
    2007 (English)In: Proceedings of the 14th International Conference on Road Safety on Four Continents (RS4C), 14-16 November, Bangkok, Thailand, Sweden: VTI , 2007, p. 1-12Conference paper, Published paper (Refereed)
    Abstract [en]

    This paper presents work in progress to study information sharing among road safety organizations. The focus is to study accident data acquisition system. In 2002, Swedish Road Transport authority (SRT) has accepted STRADA as accident reporting system to be used by the police all over Sweden. Such system is vital for coordinating, maintaining and auditing road safety in the country. Normally road accidents are reported by the police or by Emergency unit at the hospital. However more than 50% of the hospitals in Sweden didn’t use the system which decrease the utilization of the system and reduce the quality of the information that demanded. By using system thinking approach in this study we try to see why such situation is occurred and how changes can be introduced and handle to overcome such problem. Interviews conducted with focus group and different users of the system. To investigate the issues related to the acceptance of the system we use Technology Acceptance Model (TAM). We recommend getting the user involved in the life cycle of the STRADA and also the developers could use enabling system to overcome problems in related to system usability and complexity. Also we suggest the use of iterative development to govern the life cycle.

    Place, publisher, year, edition, pages
    Sweden: VTI, 2007
    Keywords
    STRADA Information sharing Road accidents recording system
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13188 (URN)
    Available from: 2008-04-28 Created: 2008-04-28 Last updated: 2009-04-23Bibliographically approved
    6. Knowledge Discovery in Road Accidents Database Integration of Visual and Automatic Data Mining Methods
    Open this publication in new window or tab >>Knowledge Discovery in Road Accidents Database Integration of Visual and Automatic Data Mining Methods
    2008 (English)In: International Journal of Public Information Systems, ISSN 1653-4360, Vol. 1, p. 59-85Article in journal (Refereed) Published
    Abstract [en]

    Road accident statistics are collected and used by a large number of users and this can result in a huge volume of data which requires to be explored in order to ascertain the hidden knowledge. Potential knowledge may be hidden because of the accumulation of data, which limits the exploration task for the road safety expert and, hence, reduces the utilization of the database. In order to assist in solving these problems, this paper explores Automatic and Visual Data Mining (VDM) methods. The main purpose is to study VDM methods and their applicability to knowledge discovery in a road accident databases. The basic feature of VDM is to involve the user in the exploration process. VDM uses direct interactive methods to allow the user to obtain an insight into and recognize different patterns in the dataset. In this paper, I apply a range of methods and techniques, including a paradigm for VDM, exploratory data analysis, and clustering methods, such as K-means algorithms, hierarchical agglomerative clustering (HAC), classification trees, and self-organized-maps (SOM). These methods assist in integrating VDM with automatic data mining algorithms. Open source VDM tools offering visualization techniques were used. The first contribution of this paper lies in the area of discovering clusters and different relationships (such as the relationship between socioeconomic indicators and fatalities, traffic risk and population, personal risk and car per capita, etc.) in the road safety database. The methods used were very useful and valuable for detecting clusters of countries that share similar traffic situations. The second contribution was the exploratory data analysis where the user can explore the contents and the structure of the data set at an early stage of the analysis. This is supported by the filtering components of VDM. This assists expert users with a strong background in traffic safety analysis to be able to intimate assumptions and hypotheses concerning future situations. The third contribution involved interactive explorations based on brushing and linking methods; this novel approach assists both the experienced and inexperienced users to detect and recognize interesting patterns in the available database. The results obtained showed that this approach offers a better understanding of the contents of road safety databases, with respect to current statistical techniques and approaches used for analyzing road safety situations.

    Keywords
    Visual data mining, K-Means, HAC, SOM, InfoVis, IRTAD, GLOBESAFE
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-13189 (URN)
    Available from: 2008-04-28 Created: 2008-04-28 Last updated: 2009-01-26
  • 472.
    Abugessaisa, Imad
    Linköping University, Department of Computer and Information Science, GIS. Linköping University, The Institute of Technology.
    Knowledge Discovery in Road Accidents Database Integration of Visual and Automatic Data Mining Methods2008In: International Journal of Public Information Systems, ISSN 1653-4360, Vol. 1, p. 59-85Article in journal (Refereed)
    Abstract [en]

    Road accident statistics are collected and used by a large number of users and this can result in a huge volume of data which requires to be explored in order to ascertain the hidden knowledge. Potential knowledge may be hidden because of the accumulation of data, which limits the exploration task for the road safety expert and, hence, reduces the utilization of the database. In order to assist in solving these problems, this paper explores Automatic and Visual Data Mining (VDM) methods. The main purpose is to study VDM methods and their applicability to knowledge discovery in a road accident databases. The basic feature of VDM is to involve the user in the exploration process. VDM uses direct interactive methods to allow the user to obtain an insight into and recognize different patterns in the dataset. In this paper, I apply a range of methods and techniques, including a paradigm for VDM, exploratory data analysis, and clustering methods, such as K-means algorithms, hierarchical agglomerative clustering (HAC), classification trees, and self-organized-maps (SOM). These methods assist in integrating VDM with automatic data mining algorithms. Open source VDM tools offering visualization techniques were used. The first contribution of this paper lies in the area of discovering clusters and different relationships (such as the relationship between socioeconomic indicators and fatalities, traffic risk and population, personal risk and car per capita, etc.) in the road safety database. The methods used were very useful and valuable for detecting clusters of countries that share similar traffic situations. The second contribution was the exploratory data analysis where the user can explore the contents and the structure of the data set at an early stage of the analysis. This is supported by the filtering components of VDM. This assists expert users with a strong background in traffic safety analysis to be able to intimate assumptions and hypotheses concerning future situations. The third contribution involved interactive explorations based on brushing and linking methods; this novel approach assists both the experienced and inexperienced users to detect and recognize interesting patterns in the available database. The results obtained showed that this approach offers a better understanding of the contents of road safety databases, with respect to current statistical techniques and approaches used for analyzing road safety situations.

  • 473.
    Abugessaisa, Imad
    et al.
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Sivertun, Åke
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Benchmarking Road Safety Situations Using OGC Model of Portrayal Workflow2005In: Proceedings of the 13th International Conference on Geoinformatics (GeoInformatics’5), 17-19 August, Toronto, Canada: Ryerson University, 2005Conference paper (Other academic)
  • 474.
    Abugessaisa, Imad
    et al.
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Sivertun, Åke
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    ICT in regional networks in the field of culture and development cooperation in 15th Americas Conference on Information Systems 2009, AMCIS 2009, vol 4, issue , pp 2667-26742009In: AMCIS 2009 Proceedings, 15th Americas Conference on Information Systems 2009,, 2009, Vol. 4, p. 2667-2674Conference paper (Refereed)
    Abstract [en]

    This paper presents results from a mapping study commissioned by Swedish International Development Agency (Sida), which has supported regional and global networking within the field of culture. The mapping study was carried out in East Africa to find ways to collect and use experiences already made and to draw conclusions on the status and use of ICT in the culture networks supported by Sida. Another goal was to gain an understanding of the level to which ICT is used within the cultural sectors in East Africa. The study was focused on two main cultural sectors - museums and drama/theatre. A variety of research methods were used. It was found that there were well-established culture networks in both theatre and museum sectors. Through these networks, ICT has been used for sharing knowledge as well as being a tool for communication. Also it has supported dialogue among many different culture groups in the region. © (2009) by the AIS/ICIS Administrative Office All rights reserved.

  • 475.
    Abugessaisa, Imad
    et al.
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Sivertun, Åke
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Ontological Approach to Modeling Information Systems2004In: Proceedings of the Fourth International Conference on Computer and information Technology (Cit'04), 14–16 September, Wuhan, China: IEEE Computer Society, Washington, DC, 2004, p. 1122-1127Conference paper (Other academic)
    Abstract [en]

    In recent years, the use of formal tools in information system modeling and development represents a potential area of research in computer science. In 1967, the term ontology appeared for the first time in computer science literature as S. H. Mealy introduced it as a basic foundation in data modeling. The main objective of this paper is to discuss the concept of ontology (from a philosophical perspective) as it was used to bridge the gap between philosophy and information systems science, and to investigate ontology types that can be found during ontological investigation and the methods used in the investigation process. The secondary objective of this paper is to study different design and engineering approaches of ontology as well as development environments that are used to create and edit ontologies.

  • 476.
    Abugessaisa, Imad
    et al.
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Sivertun, Åke
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Le Duc, Michael
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    A Systemic View on Swedish Traffic Accident Data Acquisition System2007In: Proceedings of the 14th International Conference on Road Safety on Four Continents (RS4C), 14-16 November, Bangkok, Thailand, Sweden: VTI , 2007, p. 1-12Conference paper (Refereed)
    Abstract [en]

    This paper presents work in progress to study information sharing among road safety organizations. The focus is to study accident data acquisition system. In 2002, Swedish Road Transport authority (SRT) has accepted STRADA as accident reporting system to be used by the police all over Sweden. Such system is vital for coordinating, maintaining and auditing road safety in the country. Normally road accidents are reported by the police or by Emergency unit at the hospital. However more than 50% of the hospitals in Sweden didn’t use the system which decrease the utilization of the system and reduce the quality of the information that demanded. By using system thinking approach in this study we try to see why such situation is occurred and how changes can be introduced and handle to overcome such problem. Interviews conducted with focus group and different users of the system. To investigate the issues related to the acceptance of the system we use Technology Acceptance Model (TAM). We recommend getting the user involved in the life cycle of the STRADA and also the developers could use enabling system to overcome problems in related to system usability and complexity. Also we suggest the use of iterative development to govern the life cycle.

  • 477.
    Abugessaisa, Imad
    et al.
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Sivertun, Åke
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    Le Duc, Michael
    Linköping University, Department of Computer and Information Science, GIS - Geographical Information Science Group. Linköping University, The Institute of Technology.
    GLOBESAFE: A Platform for Information-Sharing Among Road Safety Organizations2007In: IFIP-W.G. 9th International Conference on Social Implications of Computers in Developing Countries: May 2007, São Paulo, Brazil, 2007, p. 1-10Conference paper (Refereed)
  • 478.
    Abugessaisa, Imad
    et al.
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    Sivertun, Åke
    Linköping University, Department of Computer and Information Science, GIS. Linköping University, The Institute of Technology.
    Le Duc, Michael
    Linköping University, Department of Computer and Information Science, GIS. Linköping University, The Institute of Technology.
    Map as Interface for Shared Information: A Study of Design Principles and User Interaction Satisfaction2006In: IADIS International Conference WWW/Internet 2006: Murcia, Spain, 2006, p. 377-384Conference paper (Refereed)
  • 479.
    Abusagr, Sophia
    Linköping University, Department of Social and Welfare Studies.
    Den svenska integrationen: ett politiskt dilemma2007Independent thesis Basic level (degree of Bachelor), 10 points / 15 hpStudent thesis
    Abstract [sv]

    I dagens svenska samhälle har vi blivit allt mer mångkulturella och integration har därmed blivit en viktig fråga. Vi präglas av en mängd olika nationaliteter, etniska minoriteter samt olika kulturella bakgrunder. Därför är det viktigt för ett land som Sverige som anses vara demokratiskt att ha förståelse och respektera alla människor, oavsett vilken etnicitet och kulturell bakgrund en person har. Förståelse för varandra är oerhört viktigt eftersom alla som är en del av samhället inte skall känna ett utanförskap eller bli diskriminerade. Detta förekommer dock enligt en rad olika (författare och forskare) som har hävdat att den integrationspolitik som har förts i Sverige de senaste trettio åren har misslyckats. Därmed behöver det ske en förändring inom integrationspolitiken, ansvaret ligger på både den nuvarande borgerliga regeringen men lika väl invånarna i samhället. I detta projektarbete har jag analyserat olika rapporter utifrån Statens offentliga utredningar (SOU) för att på så sätt få en mer övergripande bild av hur integration förts i Sverige. Därtill belyser jag hur regeringspropositionerna ser ut gällande de mål och visioner, som den föregående regeringen, socialdemokraterna, hade för att skapa en god integrationspolitik.

  • 480.
    Abusagr, Sophia
    Linköping University, Department of Social and Welfare Studies.
    Synen på mångfald och jämställdhet vid vägverket2008Independent thesis Advanced level (degree of Master (One Year)), 20 points / 30 hpStudent thesis
    Abstract [en]

    Research has shown that still today mostly men inhibit the managing director positions and jobs such as electricians, engineers, and road workers, which makes the work situation unequal among those work places. Another issue is that studies show that minority groups have fewer possibilities in comparison with majority inhabitants on the labour market. One reason can be that many companies and organizations lack when it comes to the recruitment process due to prejudices and the applicants for a job who has names such as Ahmed, Carlos and Ali are taken out of the process at first stage.

    The purpose of this research is to study how civil servants at Vägverket (Swedish Road Administration) discuss about diversity and equality. Whereas subjects such as ethnicity and gender will be illuminated.

  • 481.
    Abuzeid, Nadir
    et al.
    Medical and Aromat Plants Research Institute, Sudan; Omdurman Islamic University, Sudan.
    Kalsum, Sadaf
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
    Koshy, Richin John
    Larsson, Marie C
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
    Glader, Mikaela
    Andersson, Henrik
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
    Raffetseder, Johanna
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
    Pienaar, Elsje
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
    Eklund, Daniel
    Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences.
    Alhassan, Muddathir S.
    Medical and Aromat Plants Research Institute, Sudan.
    AlGadir, Haidar A.
    Medical and Aromat Plants Research Institute, Sudan.
    Koko, Waleed S.
    Medical and Aromat Plants Research Institute, Sudan.
    Schon, Thomas
    Kalmar County Hospital, Sweden.
    Ahmed Mesaik, M.
    University of Kebangsaan Malaysia, Malaysia; University of Karachi, Pakistan.
    Abdalla, Omer M.
    University of Karachi, Pakistan.
    Khalid, Asaad
    Medical and Aromat Plants Research Institute, Sudan.
    Lerm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
    Antimycobacterial activity of selected medicinal plants traditionally used in Sudan to treat infectious diseases2014In: Journal of Ethnopharmacology, ISSN 0378-8741, E-ISSN 1872-7573, Vol. 157, p. 134-139Article in journal (Refereed)
    Abstract [en]

    Ethnopharmacological relevance: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need for continuous development of new and efficient methods to determine the susceptibility of isolates of Mycobacterium tuberculosis in the search for novel antimycobacterial agents. Natural products constitute an important source of new drugs, and design and implementation of antimycobacterial susceptibility testing methods are necessary to evaluate the different extracts and compounds. In this study we have explored the antimycobacterial properties of 50 ethanolic extracts from different parts of 46 selected medicinal plants traditionally used in Sudan to treat infectious diseases. Materials and methods: Plants were harvested and ethanolic extracts were prepared. For selected extracts, fractionation with hydrophilic and hydrophobic solvents was undertaken. A luminometry-based assay was used for determination of mycobacterial growth in broth cultures and inside primary human macrophages in the presence or absence of plant extracts and fractions of extracts. Cytotoxicity was also assessed for active fractions of plant extracts. Results: Of the tested extracts, three exhibited a significant inhibitory effect on an avirulent strain of Mycobacterium tubercluosis (H37Ra) at the initial screening doses (125 and 6.25 mu g/ml). These were bark and leaf extracts of Khaya senegalensis and the leaf extract of Rosmarinus officinalis L. Further fractions of these plant extracts were prepared with n-hexane, chloroform, ethyl acetate, n-butanol, ethanol and water, and the activity of these extracts was retained in hydrophobic fractions. Cytotoxicity assays revealed that the chloroform fraction of Khaya senegalensis bark was non-toxic to human monocyte-derived macrophages and other cell types at the concentrations used and hence, further analysis, including assessment of IC50 and intracellular activity was done with this fraction. Conclusion: These results encourage further investigations to identify the active compound(s) within the chloroform fraction of Khaya senegalensis bark. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

  • 482.
    Abu-Zidan, Fikri M.
    Linköping University, Department of Biomedicine and Surgery, Surgery. Linköping University, Faculty of Health Sciences.
    Role of platelet-activating factor in sepsis and shock: an experimantal study1995Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Objectives: To study the role of platelet-activating factor (PAF) on cardiovascular and pulmonary dysfunction in sepsis and shock.

    Design: Experimental study. Setting: Trauma research unit, university department of surgery, Sweden.

    Material: 76 juvenile domestic pigs. Interventions: The effects of a specific PAF receptor antagonist (BB-882) on haemodynamics and on PAF-induced haemodynamic changes were studied (n = 16). BB-882 was given as pretreatment in non-hypotensive Escherichia coli endotoxaemia (n = 9), during resuscitation after severe haemorrhagic shock (n = 7), hefore post-ischaemic shock which was induced by clamping the aorta above the coliac axis for 45 minutes (n = 8), and as pretreatment in post-haemorrhage septic shock: (n = 6). BB~882 groups were compared with controi groups having the same number of animals which received vehicle instead.

    Major outcome measures: Heart rate, intravascular pressures, cardiac output, pulmonary and systemic vascular resistance, arteriai blood gas tensions, lung thorax compliance, serum lactic acid and blood sugar concentrations, and packed cell volume.

    Results: BB-882 effectively counleracted the PAF-induced response on the mean systemic and pulmonary arteriai pressures. lt reduced the rise in pulmonary and systemic vascular resistance and improved the cardiac output in non-hypotensive and post-haemorrhage septic shock when given as pretreatment. lt reduced the hypertension in non-hypotensive sepsis and the hypotension in post-haemorrhage septic shock. BB-8B2 did not infiuence the endotoxin-induced hypoxia or reduced lung thorax compliance in non-hypotensive sepsis and post-haemorrhage septic shock. It did not improve the mean arterial pressure or the cardiac output in haemorrhagic shock alone but it reduced the systemic vascular resistanc'e and was associated with tachycardia and acidosis. It did not affect the post-ischaemic shock after clamping the aorta.

    Conclusion: PAF is a major mediator of the cardiovascular, but not pulmonary dysfunction in sepsis whether associated with shock or not, while its role on the cardiovascular dysfunction in haemorrhagic and post-ischaemic shock is small.

  • 483. Abu-Zidan, FM
    et al.
    Siosteen, AK
    Wang, Jianpu
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery.
    Al-Ayoubi, Fawzi
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery.
    Lennquist, Sten
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery. Östergötlands Läns Landsting, Center for Disaster Medicine and Traumatology.
    Establishment of a teaching animal model for sonographic diagnosis of trauma2004In: Journal of Trauma, ISSN 0022-5282, E-ISSN 1529-8809, Vol. 56, no 1, p. 99-104Article in journal (Refereed)
    Abstract [en]

    Background: Ultrasound is widely accepted as a valuable diagnostic tool for detecting intra-abdominal and intrathoracic bleeding in trauma patients. Nevertheless, many doctors are reluctant to use it because they do not have sufficient training. This study aimed to define intraabdominal and intrathoracic fluid volumes that can be detected by sonography and their relation to fluid width in pigs to establish a clinically relevant animal model for teaching and training. Methods: Different volumes of normal saline were infused into the abdomen (50-2,000 mL) and chest (25-250 mL) in five anesthetized pigs. The maximum width of fluid as detected by ultrasound was recorded. The right upper quadrant, left upper quadrant, pelvis, and right paracolic section of the abdomen and right pleural cavity were studied. An experienced radiologist performed the studies. The effects on respiratory and cardiovascular functions were evaluated. Results: The sonographic findings in the pig were similar to those in humans. Up to 50 mL of intra-abdominal fluid and up to 25 mL of intrathoracic fluid could be detected by ultrasound. There was a significant correlation between the volume infused and the fluid width detected. The respiratory and cardiovascular monitoring of the animals showed that the infused intrathoracic volumes mimicked a survivable hemothorax. Conclusion: The pig may serve as an excellent clinically relevant model with which to teach surgeons detection of different volumes of intra-abdominal and intrathoracic fluids. The value of this model as an educational tool has yet to be tested.

  • 484.
    Abys, JA
    et al.
    Lucent Technol Electroplating Chem & Serv, Murray Hill, NJ 07974 USA Molex Inc, Lisle, IL USA CSM Mat Tekn Ab, Linkoping, Sweden.
    Breck, GF
    Lucent Technol Electroplating Chem & Serv, Murray Hill, NJ 07974 USA Molex Inc, Lisle, IL USA CSM Mat Tekn Ab, Linkoping, Sweden.
    Straschil, HK
    Lucent Technol Electroplating Chem & Serv, Murray Hill, NJ 07974 USA Molex Inc, Lisle, IL USA CSM Mat Tekn Ab, Linkoping, Sweden.
    Boguslavsky, I
    Lucent Technol Electroplating Chem & Serv, Murray Hill, NJ 07974 USA Molex Inc, Lisle, IL USA CSM Mat Tekn Ab, Linkoping, Sweden.
    Holmbom, G
    Lucent Technol Electroplating Chem & Serv, Murray Hill, NJ 07974 USA Molex Inc, Lisle, IL USA CSM Mat Tekn Ab, Linkoping, Sweden.
    New methods for coating surfaces - Palladium-cobalt alloy for electrical engineering and electronics1999In: Metall (Berlin. 1947), ISSN 0026-0746, Vol. 53, no 11, p. 622-625Article in journal (Refereed)
  • 485.
    Acar, Sandra
    Linköping University, Department for Studies of Social Change and Culture, Culture, Society, Media Production.
    Dödshjälp: En undersökning om hur argumentationen om dödshjälp ser ut i artiklar2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Mitt syfte är att undersöka hur dödshjälpsdebatten lyfts fram i tidningsartiklar för att därefter beskriva hur de olika argumenten diskuteras. Syftet med denna uppsats är också att undersöka tankar ifrån olika perspektiv i samhället och beskriva personers upplevelser i tidningsartiklarna.

    • Hur ser argumentationen om dödshjälp ut i artiklar, återkommer argument och hurlyfts de fram?
    • Hur sammanbinds perspektiven i artiklarna med olika tanketraditioner?
  • 486.
    Accardi, Luigi
    et al.
    Università di Roma “Tor Vergata”, Italy.
    Belavkin, V. P.
    University of Nottingham, UK.
    Kent, Johyn T.
    University of Leeds, UK.
    Brody, Dorje C.
    Imperial College, London, UK.
    Bingham, N. H.
    Brunel University, Uxbridge, UK.
    Frey, Jeremy G.
    University of Southampton, UK.
    Helland, Inge S.
    University of Oslo, Norway.
    Larsson, Jan-Åke
    Linköping University, Department of Mathematics, Applied Mathematics. Linköping University, The Institute of Technology.
    Majumdar, N. K.
    London, UK.
    Minozzo, Marco
    University of Perugia, Italy.
    Thompson, J. W.
    University of Hull, UK.
    Discussion on “On quantum statistical inference” by O. E. Barndorff-Nielsen, R. D. Gill and P.E. Jupp2003In: Journal of The Royal Statistical Society Series B-statistical Methodology, ISSN 1369-7412, E-ISSN 1467-9868, Vol. 65, no 4, p. 805-816p. 805-816Article in journal (Refereed)
  • 487.
    Acerini, Carlo L.
    et al.
    University of Cambridge, England.
    Wac, Katarzyna
    University of Geneva, Switzerland.
    Bang, Peter
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
    Lehwalder, Dagmar
    Merck KGaA, Germany.
    Optimizing Patient Management and Adherence for children receiving Growth Hormone2017In: Frontiers in Endocrinology, ISSN 1664-2392, E-ISSN 1664-2392, Vol. 8, article id 313Article in journal (Refereed)
    Abstract [en]

    Poor adherence with growth hormone (GH) therapy has been associated with worse clinical outcomes, which in children relates specifically to their linear growth and loss of quality of life. The "360 degrees GH in Europe" meeting, held in Lisbon, Portugal, in June 2016 and funded by Merck KGaA (Germany), examined many aspects of GH diseases. The three sessions, entitled "Short Stature Diagnosis and Referral," "Optimizing Patient Management," and "Managing Transition," each benefited from three guest speaker presentations, followed by an open discussion and are reported as a manuscript, authored by the speakers. Reported here is a summary of the proceedings of the second session, which reviewed the determinants of GH therapy response, factors affecting GH therapy adherence and the development of innovative technologies to improve GH treatment in children. Response to GH therapy varies widely, particularly in regard to the underlying diagnosis, although there is little consensus on the definition of a poor response. If the growth response is seen to be less than expected, the possible reasons should be discussed with patients and their parents, including compliance with the therapy regimen. Understanding and addressing the multiple factors that influence adherence, in order to optimize GH therapy, requires a multi-disciplinary approach. Because therapy continues over many years, various healthcare professionals will be involved at different periods of the patients journey. The role of the injection device for GH therapy, frequent monitoring of response, and patient support are all important for maintaining adherence. New injection devices are incorporating electronic technologies for automated monitoring and recording of clinically relevant information on injections. Study results are indicating that such devices can at least maintain GH adherence; however, acceptance of novel devices needs to be assessed and there remains an on-going need for innovations.

  • 488.
    Acevedo, Juan Pablo
    et al.
    Univ Los Andes, Chile; Cells Cells, Chile.
    Angelopoulos, Ioannis
    Univ Los Andes, Chile; Cells Cells, Chile.
    van Noort, Danny
    Linköping University, Department of Physics, Chemistry and Biology, Biotechnology. Linköping University, Faculty of Science & Engineering. Univ Los Andes, Chile.
    Khoury, Maroun
    Univ Los Andes, Chile; Cells Cells, Chile; Consorcio Regenero, Chile.
    Microtechnology applied to stem cells research and development2018In: Regenerative Medicine, ISSN 1746-0751, E-ISSN 1746-076X, Vol. 13, no 2, p. 233-248Article, review/survey (Refereed)
    Abstract [en]

    Microfabrication and microfluidics contribute to the research of cellular functions of cells and their interaction with their environment. Previously, it has been shown that microfluidics can contribute to the isolation, selection, characterization and migration of cells. This review aims to provide stem cell researchers with a toolkit of microtechnology (mT) instruments for elucidating complex stem cells functions which are challenging to decipher with traditional assays and animal models. These microdevices are able to investigate about the differentiation and niche interaction, stem cells transcriptomics, therapeutic functions and the capture of their secreted microvesicles. In conclusion, microtechnology will allow a more realistic assessment of stem cells properties, driving and accelerating the translation of regenerative medicine approaches to the clinic.

  • 489.
    Acevedo, Miguel
    Linköping University, Department of Electrical Engineering, Computer Engineering.
    FPGA-Based Hardware-In-the-Loop Co-Simulator Platform for SystemModeler2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis proposes and implements a flexible platform to perform Hardware-In-the-Loop (HIL) co-simulation using a Field-Programmable-Gate-Array (FPGA). The HIL simulations are performed with SystemModeler working as a software simulator and the FPGA as the co-simulator platform for the digital hardware design. The work presented in this thesis consists of the creation of: A communication library in the host computer, a system in the FPGA that allows implementation of different digital designs with varying architectures, and an interface between the host computer and the FPGA to transmit the data. The efficiency of the proposed system is studied with the implementation of two common digital hardware designs, a PID controller and a filter. The results of the HIL simulations of those two hardware designs are used to verify the platform and measure the timing and area performance of the proposed HIL platform.

  • 490.
    Achen, Thomas
    Linköping University, The Tema Institute, Technology and Social Change. Linköping University, Faculty of Arts and Sciences.
    Den bioetiske udfordring: Et retspolitisk studie om forholdet mellem etik, politik og ret i det lovforberedende arbejde vedrørende bio- og genteknologi i Danmark, Norge og Sverige1997Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Biotechnology and genetic engineering raise a number of new ethical problems. Consequently, over the past 15 years, several European countries, including the Nordic countries, have passed new laws in an attempt to deal with the ethical problems posed by biotechnology. These developments raise the question of how to formulate legislation to regulate both the technical and ethical aspects of biotechnology and genetic engineering. Is it indeed possible to formulate a valid ethical framework in a thoroughly secularised society? How has this been coped with politically? And what is the nature of the relationship between ethics, politics and the law, that emerges from this process? The regulation of biotechnology is very often carried out by legal means in modern society. The thesis shows that the distinction between ethics, politics and the law - inherent in the Scandinavian tradition of legal realism - is not sustained in the law preparatory Process in the fields of biotechnology and genetic engineering in Denmark, Norway and Sweden. The analysis reveals that the tendency for ethics, politics and the law to merge is expressed in the new normative reflexivity which characterizes legislation in this area. The thesis defines this process in terms of four elements: a proceduralisation of ethics, a democratisation of ethics; negotiated development of norms, and a moralisation of politics and the law. These new tendencies suggest a need for a new analytical framework. The thesis argues that reflexive law theory and discourse ethics theory can provide a more adequate understanding of the new normative reflexivity inherent in the legislation examined. In a society characterised by moral, social, cultural and political pluralism it is of profound importance to contemplate how legal and political norms are developed. Furthermore, it is highly pertinent to consider how we can conceive these processes in theoretical terms.

  • 491.
    Achen, Thomas
    Linköping University, The Tema Institute, Technology and Social Change. Linköping University, Faculty of Arts and Sciences.
    Nedslag i svensk biopolitik: Gentekniknævnet 1994-20032005Report (Other academic)
    Abstract [no]

    Hvad er beipolitk? Hvordan kan den svenske biopolitik beskrives? Hvilken rolle har Gentekniknænet i den svenske biopolitik? Og hvad er egentlig Gentekniknænet for et nævn? Hvorfor oprettede man det? Og hvordan arbejder Gentekniknænet? Det er nogle af de spøsmål som diskuteres i denne bog.

  • 492.
    Achichi, Manel
    et al.
    Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier (LIRMM), France; University of Montpellier, France.
    Cheatham, Michelle
    Wright State University, USA.
    Dragisic, Zlatan
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    Euzenat, Jerome
    INRIA, France; University Grenoble Alpes, Grenoble, France.
    Faria, Daniel
    Instituto Gulbenkian de Ciencia, Lisbon, Portugal.
    Ferrara, Alfio
    Universita degli studi di Milano, Italy.
    Flouris, Giorgos
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Fundulaki, Irini
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Harrow, Ian
    Pistoia Alliance Inc., USA.
    Ivanova, Valentina
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    Jimenez-Ruiz, Ernesto
    University of Oslo, Norway.
    Kolthoff, Kristian
    University of Mannheim, Germany.
    Kuss, Elena
    University of Mannheim, Germany.
    Lambrix, Patrick
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    Leopold, Henrik
    Vrije Universiteit Amsterdam, Netherlands.
    Li, Huanyu
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, Faculty of Science & Engineering.
    Meilicke, Christian
    University of Mannheim, Germany.
    Mohammadi, Majid
    Technical University of Delft, Netherlands.
    Montanelli, Stefano
    Universita degli studi di Milano, Italy.
    Pesquita, Catia
    Universidade de Lisboa, Portugal.
    Saveta, Tzanina
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Shvaiko, Pavel
    Informatica Trentina, Trento, Italy.
    Splendiani, Andrea
    Pistoia Alliance Inc., USA.
    Stuckenschmidt, Heiner
    University of Mannheim, Germany.
    Thieblin, Elodie
    Institut de Recherche en Informatique de Toulouse (IRIT), France; Universite Toulouse II, Toulouse, France.
    Todorov, Konstantin
    Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier (LIRMM), France; University of Montpellier, France.
    Trojahn, Cassia
    Institut de Recherche en Informatique de Toulouse (IRIT); Universite Toulouse II, Toulouse, France.
    Zamazal, Ondrej
    University of Economics, Prague, Czech Republic.
    Results of the Ontology Alignment Evaluation Initiative 20172017In: Proceedings of the 12th International Workshop on Ontology Matching co-located with the 16th International Semantic Web Conference (ISWC 2017) / [ed] Pavel Shvaiko, Jerome Euzenat, Ernesto Jimenez-Ruiz, Michelle Cheatham, Oktie Hassanzadeh, Aachen, Germany: CEUR Workshop Proceedings , 2017, p. 61-113Conference paper (Refereed)
  • 493.
    Achichi, Manel
    et al.
    LIRMM, University of Montpellier, France.
    Cheatham, Michelle
    Wright State University, USA.
    Dragisic, Zlatan
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    Euzenat, Jerome
    INRIA, France; Univ. Grenoble Alpes, Grenoble, France.
    Faria, Daniel
    Instituto Gulbenkian de Ciencia, Lisbon, Portugal.
    Ferrara, Alfio
    Universita degli studi di Milano, Italy.
    Flouris, Giorgos
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Fundulaki, Irini
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Harrow, Ian
    Pistoia Alliance Inc., USA.
    Ivanova, Valentina
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    Jiménez-Ruiz, Ernesto
    University of Oslo, Norway; University of Oxford, UK.
    Kuss, Elena
    University of Mannheim, Germany.
    Lambrix, Patrick
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    Leopold, Henrik
    Vrije Universiteit Amsterdam, The Netherlands.
    Li, Huanyu
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, Faculty of Science & Engineering.
    Meilicke, Christian
    University of Mannheim, Germany.
    Montanelli, Stefano
    Universita degli studi di Milano, Italy.
    Pesquita, Catia
    Universidade de Lisboa, Portugal.
    Saveta, Tzanina
    Institute of Computer Science-FORTH, Heraklion, Greece.
    Shvaiko, Pavel
    TasLab, Informatica Trentina, Trento, Italy.
    Splendiani, Andrea
    Novartis Institutes for Biomedical Research, Basel, Switzerland.
    Stuckenschmidt, Heiner
    University of Mannheim, Germany.
    Todorov, Konstantin
    LIRMM, University of Montpellier, France.
    Trojahn, Cassia
    IRIT, Toulouse, France; Université Toulouse II, Toulouse, France.
    Zamazal, Ondřej
    University of Economics, Prague, Czech Republic.
    Results of the Ontology Alignment Evaluation Initiative 20162016In: Proceedings of the 11th International Workshop on Ontology Matching, Aachen, Germany: CEUR Workshop Proceedings , 2016, p. 73-129Conference paper (Refereed)
  • 494.
    Achten, Peter A J
    et al.
    Innas BV, Breda, Netherlands.
    Vael, Georges E M
    Innas BV, Breda, Netherlands.
    Heybroek, Kim
    Volvo Construction Equipment, Eskilstuna, Sweden.
    Efficient hydraulic pumps, motors and transformers for hydraulic hybrid systems in mobile machinery2011In: VDI-Fachkonferenz Getriebe in Mobilen Arbeitsmaschinen, Düsseldorf: VDI-Wissensforum , 2011, p. 1-19Conference paper (Refereed)
    Abstract [en]

    A detailed simulation of a large 33 metric ton wheel loader, carrying out the short loading cycle, has been performed. Two systems have been compared and examined side by side:

    • The conventional system, having a mechanical transmission for driving the wheels and a conventional load sensing hydraulic circuit for the work and steering cylinders.
    • A new hydraulic hybrid system for the wheel drive and the implements, applying new and efficient hydrau- lic pumps and motors.The core of the new system is the hydraulic transformers which convert and control all the hydraulic power flows inside the loader.

    The new system results in a reduction of the fuel consumption of about 50% in the analyzed cycle. The new transmission and hydraulic system also results in a strong reduction of the cooler demands.

  • 495.
    Achtenhagen, Leona
    et al.
    Jönköping International Business School, Jönköping, Sweden.
    Tillmar, Malin
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    With a focus on context - studies on women's entrepreneurship from Nordic countries and beyond: Guest Editorial2012In: International Journal of Gender and Entrepreneurship, ISSN 1756-6266, E-ISSN 1756-6274, Vol. 5, no 1, p. 4-16Article in journal (Refereed)
    Abstract [en]

    Purpose– The purpose of this paper is to direct attention to recent research on women's entrepreneurship, focusing on Nordic countries.Design/methodology/approach– The paper encourages research that investigates how context, at the micro, meso and macro level, is related to women's entrepreneurship, and acknowledges that gender is socially constructed.Findings– This paper finds evidence that recent calls for new directions in women's entrepreneurship research are being followed, specifically with regard to how gender is done and how context is related to women's entrepreneurial activities.Originality/value– This paper assesses trends in research on women's entrepreneurship, mainly from the Nordic countries.

  • 496.
    Achu, Denis
    Linköping University, Department of Computer and Information Science.
    Application of Gis in Temporal and Spatial Analyses of Dengue Fever Outbreak: Case of Rio de Janeiro, Brazil2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Since Dengue fever (DF) and its related forms, Dengue Hemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS) have become important health concerns worldwide, it is also imperative to develop methods which will help in the analysis of the incidences. Dengue fever cases are growing in number as it also invades widely, affecting larger number of countries and crossing climatic boundaries. Considering that the disease as of now has neither an effective vaccine nor a cure, monitoring in order to prevent or control is the resorted alternative. GIS and its related technologies offer a wealth of interesting capabilities towards achieving this goal.

    The intention of this study was to develop methods to describe dengue fever outbreaks taking Rio de Janeiro, Brazil as a case study. Careful study of Census data with appropriate attributes was made to find out their potential influence on dengue fever incidence in the various regions or census districts. Dengue incidence data from year 2000 to year 2008 reported by the municipal secretariat of Rio was used to extract the necessary census districts. Base map files in MapInfo format were converted to shape files.  Using ArcGIS it was possible to merge the dengue fever incidence data with the available base map file of the City of Rio according to corresponding census districts. Choropleth maps were then created using different attributes from which patterns and trends could be used to describe the characteristic of the outbreak with respect to the socio-economic conditions. Incidence data were also plotted in Excel to see temporal variations. Cluster analysis were performed with the Moran I technique on critical periods and years of dengue outbreak. Using the square root of dengue incidence from January to April 2002 and 2008, inverse distance was selected as the conceptualised spatial relationship, Euclidean distance as the distance method. More detailed analyses were then done on the selected critical years of dengue outbreak, (years 2002 and 2008), to investigate the influence of socio-economic variables on dengue incidence per census district.

     

    Dengue incidence rate appeared to be higher during the rainy and warmer months between December and May. Outbreaks of dengue occurred in years 2002 and 2008 over the study period of year 2000 to 2008. Some factors included in the census data were influential in the dengue prevalence according to districts. Satisfactory results can be achieved by using this strategy as a quick method for assessing potential dengue attack, spread and possible enabling conditions. The method has the advantage where there is limited access to field work, less financial means for acquisition of data and other vital resources.

    A number of difficulties were encountered during the study however and leaves areas where further work can be done for improvements. More variables would be required in order to make a complete and comprehensive description of influential conditions and factors.  There is still a gap in the analytical tools required for multi-dimensional investigations as the ones encountered in this study.  It is vital to integrate ‘GPS’ and ‘Remote Sensing’ in order to obtain a variety of up-to-date data with higher resolution.

     

  • 497.
    Achu Nges, Ivo
    et al.
    Department of Biotechnology, Lund Univeristy.
    Björn, Annika
    Linköping University, The Tema Institute, Department of Water and Environmental Studies. Linköping University, Faculty of Arts and Sciences.
    Björnsson, Lovisa
    Department of Biotechnology, Lund University.
    Stable operation during pilot-scale anaerobic digestion of nutrient-supplemented maize/sugar beet silage2012In: Bioresource Technology, ISSN 0960-8524, E-ISSN 1873-2976, Vol. 118, p. 445-454Article in journal (Refereed)
    Abstract [en]

    Biogas production from maize/sugar beet silage was studied under mesophilic conditions in a continuous stirred tank reactor pilot-scale process. While energy crop mono-digestion is often performed with very long hydraulic retention times (HRTs), the present study demonstrated an efficient process operating with a 50-day HRT and a corrected total solids (TScorr) based organic loading rate of 3.4 kg/m3×d. The good performance was attributed to supplementation with both macro- and micronutrients and was evidenced by good methane yields (318 m3/ton TScorr) which were comparable to laboratory maximum expected yields plus low total volatile fatty acid concentrations (< 0.8 g/L). A viscoplastic and thixotropic digester fluid behaviour was observed, and the viscosity problems common in crop mono-digestion were not seen in this study. The effluent also complied with Swedish certification standards for bio-fertilizer for farmland application. Nutrient addition thus rendered a stable biogas process, while the effluent was a good quality bio-fertilizer.

  • 498.
    Ackelid, Ulf
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Armgarth, M.
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Spetz, Anita
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology, Applied Physics. Linköping University, The Institute of Technology.
    Ethanol sensitivity of palladium-gate metal-oxide-semiconductor structures1986In: IEEE Electron Device Letters, ISSN 0741-3106, E-ISSN 1558-0563, Vol. 7, no 6, p. 353-355Article in journal (Refereed)
    Abstract [en]

    Hydrogen-sensitive palladium-gate MOS structures heated above 150°C show sensitivity to ethanol vapor. The effect is probably due to catalytic dehydrogenation of adsorbed ethanol molecules on the surface of the palladium gate.

  • 499.
    Ackelman, Jenny
    Linköping University, Department of Physics, Chemistry and Biology.
    Alternative splicing and its regulation under normal and abnormal conditions2010Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    During the maturation of pre-mRNA introns are removed and exons are spliced together, to form a primary transcript, a reaction that is catalyzed by the spliceosome. Alternative splicing is a complex reaction that mainly utilizes one of four mechanisms; exon skipping, 5’ splice site choice, 3’ splice site choice and intron retention. To achieve accurate splicing four sequence elements are essential, two of which are located in the splice sites themselves; 5’ splice sites and 3’ splice sites, but also the polypyrimidine tract and the branch point sequence. Alternative splicing can be regulated by histone or chromatin modulations, siRNA, transcription efficiency and various proteins, many of which belong to either the SR protein family or the hnRNP family of proteins. SR proteins usually promote exon inclusion, while hnRNP proteins usually promote exon skipping. There are also regulatory elements that are called exonic splicing enhancers or silencers depending on if they promote or inhibit the inclusion of the exon they reside in. These elements also exist in introns and are then called intronic splicing enhancers or silencers. The enhancer elements are most commonly targeted by SR proteins and the silencer elements are usually targeted by hnRNP proteins. This paper will mainly focus on the regulation of alternative splicing and the role of alternative splicing under abnormal conditions, such as when mutations cause disease.

  • 500.
    Ackerfors, Linnea
    et al.
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences.
    Hederén, Amanda
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences.
    Climate Transition in Municipalities: Identifying ways to assess transition processes through indicators2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Climate change has been recognised as one of the biggest challenges of our time. To prevent further climate change impacts, nations at COP21 further stressed the need to mitigate their greenhouse gas emissions enough to prevent dangerous temperature rise and to adapt societies to become more resilient. Municipals have been found important actors in this transition due to their power to inflict change on a local level. However, there is a lack of methods to assess how transition is made due to the fact that transition is a fairly new approach to managing climate change combined with a lack of completed transitions in municipalities. The purpose of this study is to explore the use of indicators as a method to assess municipal transition processes. Focusing on two Swedish municipalities that have been deemed vulnerable but at the same time apt to combat climate change, this study uses a triangulation of methods that are divided into two phases. The first phase uses a literature review in order to create a scientifically based list of transition indicators. The second phase uses document analyses and interviews in order to test the indicators and analyse transition process on a local level. The study revealed that there are multiple barriers and triggers for transition such as conflicting interests, economic factors, political steering, knowledge building- and awareness and long term perspectives, but that there also exist important tools for municipal transition in the form of networks through multi-level collaborations and plans/objectives. The findings in this study also suggests that the use of indicators as a method to assess transition could be viable, but that it is limited due to its contextual nature and lack of successful transitions to compare with.

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