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  • 51.
    Aaslund, Ulrika
    et al.
    Linköping University, Department of Management and Economics.
    Larsson Jagbrant, Anna
    Linköping University, Department of Management and Economics.
    Nutida uppfattningar om svensk utrikespolitik: en diskursanalays av svenska politikers föreställningar om utrikespolitik idag2005Independent thesis Advanced level (degree of Magister), 10 points / 15 hpStudent thesis
    Abstract [en]

    The purpose of our essay is to investigate the discourse of foreign policy from a Swedish perspective. In this essay we explore how Swedish politicians discuss the Swedish foreign policy of today and of the future. The study is based on interviews with seven members of The Advisory Council on Foreign Affairs of the Swedish Riksdag. The point of departure for our analysis of these members’ narratives is discourse analysis and discourse theory. In history Swedish foreign policy has been associated with neutrality and the work for important values such as human rights and disarmament. However, as a consequence of the development of a common foreign and security policy for Europe, there is a debate concerning what Swedish foreign policy is today. Furthermore, there is today an academic debate about how foreign policy is to be understood in a more and more internationalized world. This makes our study of the understanding of foreign policy of Swedish politicians highly legitimate.

    In our study we show that both unity and difference of opinion is present in the discourse of foreign policy that the interviewees give voice to. During our interviews we found that foreign policy was defined as relations between states and that the right of states to pursue foreign policy was commonly seen as derived from the thought that citizens of a state share a common identity. During the interviews it also became obvious that feelings of belonging to a certain group were thought to affect European foreign policy cooperation. To sum up the results of our study we conclude that a deeply rooted sense of identity seem to be very influential when it comes to the understanding of foreign policy.

  • 52.
    Aasmundtveit, K.E.
    et al.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., N-7491 Trondheim, Norway.
    Samuelsen, E.J.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., N-7491 Trondheim, Norway.
    Guldstein, M.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., N-7491 Trondheim, Norway.
    Steinsland, C.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., N-7491 Trondheim, Norway.
    Flornes, O.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., N-7491 Trondheim, Norway.
    Fagermo, C.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., N-7491 Trondheim, Norway.
    Seeberg, T.M.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., N-7491 Trondheim, Norway.
    Pettersson, Lars
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Inganäs, Olle
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics .
    Feidenhans'l, R.
    Forskningscenter Risø, DK-4000 Roskilde, Denmark.
    Ferrer, S.
    Europ. Synchrt. Radiation Facility, BP 220, F-38043 Grenoble Cedex, France.
    Structural anisotropy of poly(alkylthiophene) films2000In: Macromolecules, ISSN 0024-9297, Vol. 33, no 8, 3120-3127 p.Article in journal (Refereed)
    Abstract [en]

    The structural anisotropy of various poly(alkylthiophene) films have been studied by X-ray diffraction, using both conventional methods and synchrotron radiation at grazing incidence. Solution-cast films orient with the side chains preferably normal to the film surface, whereas spin-cast films of nonstereoregular material orient with both the main and the side chains in the film plane. For thick (10-50 µm) solution-cast films, the degree of orientation depends strongly on the solvent used for casting, and on the stereoregularity of the polymer, films of stereoregular materials being more oriented than those of nonregular materials. The most oriented nonregular films are those cast from mixtures of chloroform and tetrahydrofuran. Thin (50-500 nm) solution-cast films are more oriented than the thicker ones, and the effects of different stereoregularity or different casting solvents are small. For spin-cast films, the degree of orientation is independent of substrate and solvent. Spin-cast films of stereoregular material have two different phases: One with the side chains normal to the substrate, and another where they are parallel to the substrate. The diffraction peaks of spin-cast poly(octylthiophene) narrow considerably upon heating.

  • 53.
    Aasmundtveit, K.E.
    et al.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., Trondheim, Norway.
    Samuelsen, E.J.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskapelige U., Trondheim, Norway.
    Inganäs, Olle
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics .
    Pettersson, Lars
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Johansson, Tomas
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Ferrer, S.
    Europ. Synchrt. Radiat. Facil. (E., F-38043, Grenoble, France.
    Structural aspects of electrochemical doping and dedoping of poly(3,4-ethylenedioxythiophene)2000In: Synthetic metals, ISSN 0379-6779, Vol. 113, no 1, 93-97 p.Article in journal (Refereed)
    Abstract [en]

    Electrochemical dedoping and redoping of p-toluene sulfonate doped poly(3,4-ethylenedioxythiophene) (PEDOT) has been studied with in situ grazing incidence diffraction with water used as an electrolyte. The diffraction peak positions and integrated intensities do not change significantly during doping and dedoping, while the peak widths increase upon dedoping and decrease upon doping. This implies that the lattice parameters and the relative positions of the polymer chains and the p-toluene sulfonate ions remain unchanged, the redox processes being carried out by the motion of smaller ions between the polymer and the electrolyte, and that the structural order decreases upon dedoping and increases upon doping in a reversible manner.

  • 54.
    Aasmundtveit, K.E.
    et al.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskaplige U., N-7491 Trondheim, Norway.
    Samuelsen, E.J.
    Institutt for Fysikk, Norges Tekn.-Naturvitenskaplige U., N-7491 Trondheim, Norway.
    Mammo, W.
    Institutionen för Organisk Kemi, Chalmers Tekniska Hôgskola, S-412 96 Göteborg, Sweden.
    Svensson, M.
    Institutionen för Organisk Kemi, Chalmers Tekniska Hôgskola, S-412 96 Göteborg, Sweden.
    Andersson, M.R.
    Institutionen för Polymerteknik, Chalmers Tekniska Hôgskola, S-412 96 Göteborg, Sweden.
    Pettersson, Lars
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Inganäs, Olle
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics .
    Structural ordering in phenyl-substituted polythiophenes2000In: Macromolecules, ISSN 0024-9297, Vol. 33, no 15, 5481-5489 p.Article in journal (Refereed)
    Abstract [en]

    Various substituted poly(phenylthiophene)s have been studied by X-ray diffraction. They are semicrystalline, with very different degrees of crystallinity. Those with para-substituted phenyl groups have a low degree of crystallinity, whereas those with ortho-substituted phenyl groups are more crystalline. The most crystalline materials in this study have two equally long substituents on the phenyl ring, one at the ortho position and the other at the ortho or meta position on the opposite side of the phenyl ring. Poly(3-(2,5-dioctylphenyl)thiophene) (PDOPT) was most thoroughly studied, and a structural model is proposed. The structure of PDOPT is quite different from previously studied substituted polythiophenes in that the octyl side chains are directed normal to the thiophene planes. In this way, the conjugated polymer chains are kept separated from each other. Solution-cast and spin-cast PDOPT films are anisotropic, with the octyl side chains oriented normal to the film surface in both cases. This is contrary to the situation for poly(3-alkylthiophene)s, where solution-cast and spin-cast films orient in different ways.

  • 55.
    Aav, Sebastian
    Linköping University, Department of Science and Technology.
    Adaptive Music System for DirectSound2005Independent thesis Advanced level (degree of Magister), 20 points / 30 hpStudent thesis
    Abstract [en]

    With the intention of surveying the field of research in adaptive audio systems for interactive media, a suggested audio system design for adaptive music control is described, and a prototype implementation of key parts of the system is presented and evaluated.

    Foregoing midi-triggered sound banks, the proposed design uses layered segmented audio files, defined and controlled by XML-scripts. The results demonstrate an inclination of a flexible system, capable of adequate adaptive behaviour of high quality sound.

    The implemented system will serve as an extensive basis for future work contributing to the research of adaptive behaviour to both music and sound effects for interactive media, and also as a preliminary foray into the more experimental field of stand-alone non-linear music playback.

  • 56. Aavikko, R.
    et al.
    Saarinen, K.
    Magnusson, Björn
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials.
    Janzén, Erik
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials.
    Clustering of Vacancies in Semi-Insulating SiC Observed with Positron Spectroscopy2006In: Materials Science Forum, Vols. 527-529, 2006, Vol. 527-529, 575-578 p.Conference paper (Refereed)
  • 57. Aavikko, R
    et al.
    Saarinen, K
    Magnusson, Björn
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials.
    Janzén, Erik
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials.
    Observation of vacancy clusters in HTCVD grown SiC2005In: Materials Science Forum, Vols. 483-485, 2005, Vol. 483, 469-472 p.Conference paper (Refereed)
    Abstract [en]

    Positron lifetime spectroscopy was used to study defects in semi-insulating (SI) silicon carbide (SiC) substrates grown by high-temperature chemical vapor deposition (HTCVD). The measured positron lifetime spectra can be decomposed into two components, of which the longer corresponds to vacancy clusters. We have carried out atomic superposition calculations to estimate the size of these clusters.

  • 58. Aavikko, R.
    et al.
    Saarinen, K.
    Tuomisto, F.
    Magnusson, Björn
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, The Institute of Technology.
    Nguyen, Son Tien
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, The Institute of Technology.
    Janzén, Erik
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, The Institute of Technology.
    Clustering of vacancy defects in high-purity semi-insulating SiC2007In: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 75, no 8, 085208- p.Article in journal (Refereed)
    Abstract [en]

    Positron lifetime spectroscopy was used to study native vacancy defects in semi-insulating silicon carbide. The material is shown to contain (i) vacancy clusters consisting of four to five missing atoms and (ii) Si-vacancy-related negatively charged defects. The total open volume bound to the clusters anticorrelates with the electrical resistivity in both as-grown and annealed materials. Our results suggest that Si-vacancy-related complexes electrically compensate the as-grown material, but migrate to increase the size of the clusters during annealing, leading to loss of resistivity. © 2007 The American Physical Society.

  • 59.
    Aazh, H
    et al.
    Ealing General Hospital.
    Moore, B
    Cambridge University.
    Peyvandi, AA
    Ealing General Hospital.
    Stenfelt, Stefan
    Chalmers University of Technology.
    Influence of ear canal occlusion and static pressure difference on bone conduction thresholds: Implications for mechanisms of bone conduction2005In: International Journal of Audiology, ISSN 1499-2027, Vol. 44, no 5, 302-306 p.Article in journal (Refereed)
    Abstract [en]

    The effect of air pressure change on bone conduction (BC) hearing thresholds in the occluded ear was investigated. The pump manometer system of an impedance bridge was used to change the air pressure in the ear canal of twenty-two normally hearing subjects. BC thresholds were measured with: (1) open ear; (2) the ear canal occluded with a probe tube and application of 0 daPa air pressure; and (3) the ear canal occluded with a probe tube and application of -350 daPa air pressure. Thresholds were lower in condition 2 than in condition 1, the difference decreasing from 27 dB at 2500 Hz to 4.5 dB at 2000 Hz. Thresholds were higher in condition 3 than in condition 2. The results are interpreted in terms of changes in the relative contribution of the three routes of transmission for BC sound produced by occlusion and by a static pressure difference.

  • 60.
    Abadei, S.
    et al.
    Department of Microelectronics, Chalmers University of Technology, 412 96 Göteborg, Sweden.
    Gevorgian, S.
    Department of Microelectronics, Chalmers University of Technology, 412 96 Göteborg, Sweden, Core Unit Research Center, Ericsson Microwave Systems, SE-431 84, Mölnda, Sweden.
    Kugler, Veronika Mozhdeh
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Helmersson, Ulf
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Plasma and Coating Physics .
    Andreasson, J.
    Department of Materials and Manufacturing Engineering, Luleå University of Technology, 971 87, Luleå, Sweden.
    Microwave properties of tunable capacitors basee on magnetron sputtered ferroelectric Na0.5K0.5NbO3 film on low and high resistivity silicon substrates2001In: Integrated Ferroelectrics, ISSN 1058-4587, Vol. 39, no 1-4, 359-366 p.Conference paper (Other academic)
    Abstract [en]

    In this work, small signal DC voltage dependent dielectric permittivity, loss tangent, and tuneability of magnetron sputtered epitaxial Na0.5K0.5NO3 films are studied experimentally. (100)-oriented Na0.5K0.5NbO3 films are deposited onto SiO2-buffered CMOS grade low resistivity (p = 10-20 cm) and high resistivity (p = 15-45 kcm) silicon substrates. Planar capacitors with 2 or 4 m gaps between electrodes have been fabricated on top of ferroelectric films. These devices have been characterized in the frequency range 1.0 MHz to 50 GHz at temperatures 30 - 300K. Na0.5K0.5NbO3/SiO2/Si structures on high resistivity silicon substrate exhibit C-V performances typical for Metal-Insulator- Semiconductor (MIS) capacitors. At low frequencies, f 1.0 GHz, the large tuneability and large losses are associated with the MIS structure, while at higher microwave frequencies the tuneability is mainly associated with the ferroelectric, film. At 1.0 MHz and room temperature, the tuneability of Na0.5K0.5NbO3/SiO2/Si structures more than 90%, reducing to 10-15 % at 50 GHz. The losses decrease with increasing the DC bias and frequency. A Q-factor more than 15 at 50 GHz is observed. The dielectric permittivity of the Na0.5K0.5NbO3 film is in the range 50-150 at frequencies 0.045-50 GHz. On low resistivity substrate the performance of Na0.5K0.5NbO3 films is completely screened by the high losses in silicon, and the tuneability is negligible. © 2001 Taylor and Francis.

  • 61.
    Abadias, Gregory
    et al.
    University of Poitiers, France.
    Sarakinos, Kostas
    Linköping University, Department of Physics, Chemistry and Biology, Plasma and Coating Physics. Linköping University, The Institute of Technology.
    Fenker, Martin
    FEM, Germany.
    Kassavetis, Spiros
    Aristotle University of Thessaloniki, Greece.
    Editorial Material: Preface in SURFACE and COATINGS TECHNOLOGY, vol 255, issue , pp2014In: Surface & Coatings Technology, ISSN 0257-8972, E-ISSN 1879-3347, Vol. 255Article in journal (Other academic)
    Abstract [en]

    n/a

  • 62.
    Abadir Guirgis, Georg
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Arts and Sciences.
    Mindre energi och rätt tid: Utvärdering av utbildning och träning för lokförare i energieffektiv körning – en simulatorstudie2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    During the 80’s, the first train simulator was introduced in Swedish train driver education and is still the only full scale simulator being used to educate train drivers in Sweden. The reason for this seems to be a lack of educational and economic motives for an expanded usage of simulators within education and training. Energy savings within the railway domain, i.e. energy-efficient driving, is currently a topic for all train operators in Sweden. Some operators already educate their drivers in energy efficient driving and tests of energy efficiency in real traffic has shown a potential energy saving of 16 %, after drivers have completed a theoretical education in energy-efficient driving. Because there were some uncertainties in the data from the tests carried out in real traffic, where conditions and experimental procedures varied between the drivers and it also turned out that education and access to a support system while driving resulted in a small saving in energy (13 %) there was a need to examine the potential savings under controlled conditions. Therefore, a study was conducted using a train simulator. In the simulator, the researcher has full control over the data and conditions are the same for all drivers. The simulator used in the study was developed by VTI (Swedish National Road and Transport Research Institute) and modeled after an X50 Regina. The purpose of this study was to investigate whether the same theoretical education in energy-efficient driving, in combination with simulator training under ideal conditions, could contribute to the same, or better energy saving compared to the results of the tests from real traffic. Furthermore, the effect of feedback during training with regard to energy savings was also investigated. 24 train driver students were divided into three groups with 8 students in each. Two of these groups completed two sessions (reference and test session) with theoretical education and simulator training between the sessions. The last group (control group) completed two sessions (reference and test session) without education and training between the sessions. The two groups that were given theoretical education conducted their simulator training under two different conditions, where one group trained with feedback (energy consumption and rail gradient) and the other group trained without feedback. It turns out that a theoretical education in energy efficient driving, combined with 30 minutes of simulator training, resulted in a total saving of about 24 % energy for both groups. Also, considering that the control group improved their energy consumption by simply driving the simulator two times (8 % total energy saving), the energy saving was almost equal to the result of the tests in real traffic. Since the results were equal even though the conditions differed, there is reason to investigate how different driving conditions affect the outcome. There is also a need to better understand why education in combination with a support system resulted in a lower energy saving than for those who were only given education during the tests in real traffic, and also why feedback during training in the simulator did not give a detectable effect. Basically, there are many reasons to further investigate how to design simulator training and support systems for train drivers. In addition to the energy savings, the results showed that drivers improved their arrival times i.e. arrive more accurate in relation to the time table. The results suggest that there is great potential for train simulators in the Swedish train driver education, both for training and for evaluating the effects of the training.

  • 63.
    Abadir Guirgis, Georg
    Linköping University, Department of Computer and Information Science.
    Lärarperspektiv på riskutbildningen för motorcyklister2011Independent thesis Basic level (degree of Bachelor), 12 credits / 18 HE creditsStudent thesis
    Abstract [sv]

    Under det senaste decenniet har det i Sverige blivit allt populärare att åka motorcykel. Enobligatorisk riskutbildning för behörighet A och A1 infördes från och med den 1 november2009. Då riskutbildningen är ny har få utvärderingar gjorts.Denna studie utvärderar riskutbildningen för motorcyklister utifrån trafikskolläraresperspektiv. Målet har varit att sammanställa synpunkter och erfarenheter från lärarna påutbildningen. Ett ytterligare mål har varit att undersöka trafikskollärarnas upplevda effekter avutbildningen på elevers trafikbeteende. Sex semistrukturerade intervjuer med trafikskolläraresamt en observationsstudie på olika trafikskolor genomfördes. Utöver detta genomfördesdeltagande observation av en fortbildning där 15 trafikskollärare deltog. Resultatet frånstudien visar att lärarna anser att behovet av riskutbildningen är stort och attimplementationen av den nya riskutbildningen gått bra. Förutom att elever efter utbildningenrefererar till den, vilket enligt lärarna indikerar att de tagit till sig vad som sagts, märks det nui större utsträckning än tidigare att elever kör lugnare och tänker sig mer för i vissasituationer. Detta påtalades vara ett klart önskvärt resultat.

  • 64.
    Aban, Kevin
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Göst, Jens
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Analysis of transports with pharmaceuticals on Arlanda airport2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Rapporten syftar till att kartlägga och analysera dagens transportflöde av läkemedel på fraktområdet Cargo City på Arlanda. Cargo Center och APH Logistics är två fraktagenter som har sin verksamhet på Cargo City. Observera att Cargo City och Cargo Center inte har samma innebörd. Cargo Center och APH Logistics erbjuder genom nära samarbete transport och hantering av temperaturkänsligt gods, som till exempel läkemedel. Läkemedel är värdefullt gods som kräver särskild skötsel vid transport, hantering och förvaring. Det ställer stränga krav på samtliga aktörer i försörjningskedjan. Genom studiebesök och intervjuer har författarna kartlagt det befintliga flödet av läkemedel. SACT, ett åkeri och dotterbolag till Cargo Center, utför transporten av godset till Cargo City med nerkylda lastbilar. APH Logistics omlastningsterminal på Cargo City är temperaturkontrollerad, vilket innebär att läkemedelsgodset förvaras och lastats i flygcontainrar där. Det färdiglastade godset forslas sedan vidare till Cargo Centers terminal. Där sker vikt- och volymkontroll av godset, det registreras i olika datasystem och slutligen märks det med etiketter, så som flygfraktsedeln. Mycket av godset som hanteras på Arlanda körs med lastbil till andra flygplatser och destinationer runt om i Europa istället för att flygfraktas direkt från flygplatsen. Dessutom hanteras och förvaras inte allt läkemedelsgods under temperaturkontrollerade former. En totalkostnadsanalys har gjorts för att jämföra olika transportflödesscenarion. Dessutom har författarna identifierat den kundservice Cargo Center och APH Logistics bör erbjuda kunden. Den bygger på kvalitativa resonemang. Resultatet av rapporten är författarnas rekommendation till företagen av hur de bör gå tillväga i framtiden. Den ger både kortsiktiga och långsiktiga tips.

  • 65.
    Abate, E.
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences. University of Gondar, Ethiopia.
    Elias, D.
    University of Southern Denmark, Denmark.
    Getachew, A.
    University of Gondar, Ethiopia.
    Alemu, S.
    University of Gondar, Ethiopia.
    Diro, E.
    University of Gondar, Ethiopia.
    Britton, S.
    Karolinska Hospital, Sweden.
    Aseffa, A.
    Armauer Hansen Research Institute, Ethiopia.
    Stendahl, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
    Schön, Thomas
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences. Kalmar County Hospital, Sweden.
    Effects of albendazole on the clinical outcome and immunological responses in helminth co-infected tuberculosis patients: a double blind randomised clinical trial2015In: International Journal of Parasitology, ISSN 0020-7519, E-ISSN 1879-0135, Vol. 45, no 2-3, 133-140 p.Article in journal (Refereed)
    Abstract [en]

    Despite several review papers and experimental studies concerning the impact of chronic helminth infection on tuberculosis in recent years, there is a scarcity of data from clinical field studies in highly endemic areas for these diseases. We believe this is the first randomised clinical trial investigating the impact of albendazole treatment on the clinical and immunological outcomes of helminth co-infected tuberculosis patients. A randomised, double-blind, placebo-controlled trial of albendazole (400 mg per day for 3 days) in helminth-positive tuberculosis patients was conducted in Gondar, Ethiopia. The primary outcome was clinical improvement (Delta TB score) after 2 months. Among secondary outcomes were changes in the levels of eosinophils, CD4+ T cells, regulatory T cells, IFN-gamma, IL-5 and IL-10 after 3 months. A total of 140 helminth co-infected tuberculosis patients were included with an HIV co-infection rate of 22.8%. There was no significant effect on the primary outcome (Delta TB score: 5.6 +/- 2.9 for albendazole versus 5.9 +/- 2.5 for placebo, P = 0.59). The albendazole-treated group showed a decline in eosinophil cells (P = 0.001) and IL-10 (P = 0.017) after 3 months. In an exploratory analysis after 12 weeks, the albendazole treated group showed a trend towards weight gain compared with the placebo group (11.2 +/- 8.5 kg versus 8.2 +/- 8.7 kg, P = 0.08)). The reductions in eosinophil counts and IL-10 show that asymptomatic helminth infection significantly affects host immunity during tuberculosis and can be effectively reversed by albendazole treatment. The clinical effects of helminth infection on chronic infectious diseases such as tuberculosis merit further characterisation. (C) 2014 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

  • 66.
    Abate, Ebba
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    The impact of helminth infection in patients with active tuberculosis2013Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The geographic distribution of helminth infection and tuberculosis (TB) overlap substantially. Experimental animal models and limited data from humans have shown that intestinal helminths could subvert the host immune response towards a T-helper 2 (Th2)-type immune response and an increased regulatory T-cell activity (Tregs). This in turn affects the host's ability to mount an effective Th1 immune-mediated protection against Mycobacterium tuberculosis. However, evidence for this hypothesis in the human setting from helminth infected TB patients is limited. This thesis primarily focuses on the immunological and clinical impact of helminth infection on pulmonary TB. The kinetics of the Quantiferon-Gold (QFN) assay, which measures IFN-³ response to TB-specific antigens in whole blood was assessed and showed a modest decline during TB treatment to the level observed for healthy blood donors. We further assessed another clinical monitoring tool, the-TB-score, composed of clinical signs and symptoms of TB, and found an early decline two weeks after initiation of TB- treatment where a failure of decline correlated with increased mortality. Overall, the helminth co-infection rate was significantly higher in TB patients compared to healthy controls. Helminth co-infection was associated to a significantly higher rate of eosinophilia and IgE-levels in healthy controls and patients with tuberculosis. During the first weeks of anti-TB treatment, a marked decrease in the rate of helminth infection was observed in HIV co-infected compared to HIV-negative TB patients. However, helminth co-infection was more common in HIV negative than HIV positive TB patients. There was no detectable impact of helminth infection on the clinical presentation of pulmonary tuberculosis. At baseline, helminth co-infected TB patients showed an increased frequency of Tregs compared to helminth negative TB patients and healthy controls. This was accompanied by an increased rate of PPD stimulated IL-5 and spontaneous production of IL-10 by peripheral blood mononuclear cells among helminth co-infected TB patients. A placebo controlled randomized trial was conducted in order to test the hypothesis that albendazole treatment of helminth positive TB patients may improve the clinical response of TB by reducing the immunmodulatory effect of helminthes on TB immunity. A total of 140 helminth co-infected TB patients were randomized to albendazole (400 mg per os for three consecutive days) or placebo. No significant difference was observed between the albendazole and placebo group in terms of the primary outcome (TB score change between baseline and week 8). Among the secondary outcomes, a significant decline of peripheral eosinophil cells was observed in the albendazole treated group, but no effect on other outcome variables (changes in chest x-ray findings, IgE level and sputum smear conversion). Regarding the immunological assessment no significant difference was observed for changes in Tregs, and PPD-induced production of IFN- ³ or IL-5 although a non-significant trend of a decrease in IL-10 expressing PBMCs were observed in the albendazole group. Taken together, the burden of helminth infection was higher in TB patients than in a healthy control group. Helminth co-infection during pulmonary TB in the human setting induces an immune response characterized by increased IgE production, eosinophilia as well as increased levels of Tregs and spontaneous IL-10 production. Thus, the immunological impact of helminth infection on the outcome and risk for developing TB merits further investigation.

    List of papers
    1. Kinetics of the QuantiFERON((R))-TB Gold In-Tube test during treatment of patients with sputum smear-positive tuberculosis in relation to initial TST result and severity of disease
    Open this publication in new window or tab >>Kinetics of the QuantiFERON((R))-TB Gold In-Tube test during treatment of patients with sputum smear-positive tuberculosis in relation to initial TST result and severity of disease
    Show others...
    2010 (English)In: Scandinavian journal of infectious diseases, ISSN 1651-1980, Vol. 42, no 9, 650-657 p.Article in journal (Refereed) Published
    Abstract [en]

    Abstract The QuantiFERON((R))-TB Gold In-Tube test (QFN) measures interferon-gamma production in response to Mycobacterium tuberculosis antigens. Our aim was to assess the kinetics of the QFN and initial tuberculin skin test (TST) result in relation to severity of disease in a tuberculosis (TB) endemic area. Smear-positive TB patients (n = 71) were recruited at Gondar University Hospital, Ethiopia. The TST, QFN, CD4+ cell count and clinical symptoms (TB score) were assessed and followed up during treatment. From baseline to 7 months after treatment, there was a significant decrease in QFN reactivity (93.8% to 62.5% in HIV-negative/TB; 70.3% to 33.3% in HIV-positive/TB patients) down to a level comparable to a control group of blood donors (51.2%). The agreement between TST and QFN was poor in TB patients compared to healthy controls. A negative TST correlated to more advanced TB in contrast to a negative QFN test. We conclude that the QFN reactivity is significantly reduced at the end of treatment against active TB to the background level of healthy blood donors, and that the agreement between TST and QFN is poor including correlation to the severity of disease.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-58804 (URN)10.3109/00365548.2010.482942 (DOI)000282716000002 ()20465490 (PubMedID)
    Available from: 2010-08-27 Created: 2010-08-27 Last updated: 2013-05-02
    2. Early treatment response evaluated by a clinical scoring system correlates with the prognosis of pulmonary tuberculosis patients in Ethiopia: A prospective follow-up study.
    Open this publication in new window or tab >>Early treatment response evaluated by a clinical scoring system correlates with the prognosis of pulmonary tuberculosis patients in Ethiopia: A prospective follow-up study.
    Show others...
    2012 (English)In: Scandinavian journal of infectious diseases, ISSN 1651-1980, Vol. 44, no 11, 828-834 p.Article in journal (Refereed) Published
    Abstract [en]

    Background: In resource-limited settings the monitoring of tuberculosis (TB) patients is challenging, and early identification of TB patients with a high mortality risk is important. The aim of this study was to investigate prospectively whether early changes in a clinical scoring system (TB score) can predict treatment outcome in Ethiopian patients with pulmonary tuberculosis. Method: TB patients (n = 250) and blood donors (n = 82) were recruited prospectively at Gondar University Hospital, Ethiopia. Clinical scoring was performed using an interview-based questionnaire and clinical examination. Results: Among TB patients (53.6% of whom were HIV co-infected) the median TB score declined from week 0 to week 2 (8 (interquartile range (IQR) 6-9) vs 4 (IQR 2-6)) and dropped to a low level at week 8, which was still significantly higher than that found in blood donors (2 (IQR 1-4) vs 0 (IQR 0-1), p < 0.0001). Patients who died had a significantly higher TB score at week 0, week 2, and week 8 than survivors. Mortality was associated with a failure to achieve a decrease greater than 25% in the TB score at 2 weeks. Baseline CD4 + cell counts (< 200 cells/mm(3)) were associated with mortality but not with initial TB score results. Conclusions: The TB score was increased during the first 2 months of treatment among patients who died. Failure to achieve a greater than 25% decrease in TB score after 2 weeks of treatment was associated with increased mortality. Repeated clinical scoring during the intensive phase of TB treatment could be useful to identify high-risk patients.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-85315 (URN)10.3109/00365548.2012.694468 (DOI)000310008900004 ()22812387 (PubMedID)
    Note

    funding agencies|Swedish Heart and Lung Foundation||EU/EDCTP project|JP 2009.10800.006|Swedish heart and lung Foundation (King Oscar II Jubilee Foundation)||EU/EDCP|JP.10800.006|

    Available from: 2012-11-15 Created: 2012-11-15 Last updated: 2013-05-02
    3. The Impact of Asymptomatic Helminth Co-Infection in Patients with Newly Diagnosed Tuberculosis in North-West Ethiopia
    Open this publication in new window or tab >>The Impact of Asymptomatic Helminth Co-Infection in Patients with Newly Diagnosed Tuberculosis in North-West Ethiopia
    Show others...
    2012 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 7, no 8Article in journal (Refereed) Published
    Abstract [en]

    Background: Areas endemic of helminth infection, tuberculosis (TB) and HIV are to a large extent overlapping. The aim of this study was to assess the impact of asymptomatic helminth infection on the immunological response among TB patients with and without HIV, their house hold contacts and community controls. less thanbrgreater than less thanbrgreater thanMethodology: Consecutive smear positive TB patients (n = 112), their household contacts (n = 71) and community controls (n = 112) were recruited in Gondar town, Ethiopia. Stool microscopy, HIV serology, serum IgE level, eosinophil and CD4 counts were performed and tuberculosis patients were followed up for 3 months after initiation of anti-TB treatment. less thanbrgreater than less thanbrgreater thanResults: Helminth co-infection rate was 29% in TB patients and 21% in both community control and household contacts (p = 0.3) where Ascaris lumbricoides was the most prevalent parasite. In TB patients the seroprevalence of HIV was 47% (53/112). Eosinophilia and elevated IgE level were significantly associated with asymptomatic helminth infection. During TB treatment, the worm infection rate of HIV+/TB patients declined from 31% (10/32) at week 0 to 9% (3/32) at week 2 of TB treatment, whereas HIV2/TB patients showed no change from baseline to week 2, 29% (13/45) vs. 22.2% (10/45). This trend was stable at week 8 and 12 as well. less thanbrgreater than less thanbrgreater thanConclusion: One third of smear positive TB patients were infected with helminths. Eosinophilia and elevated IgE level correlated with asymptomatic worm infection, indicating an effect on host immunity. The rate of worm infection declined during TB treatment in HIV+/TB co-infected patients whereas no decline was seen in HIV2/TB group.

    Place, publisher, year, edition, pages
    Public Library of Science, 2012
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-84349 (URN)10.1371/journal.pone.0042901 (DOI)000308206000014 ()
    Note

    Funding Agencies|Swedish Agency for Research Cooperation with Developing Countries||Swedish International Development Cooperation Agency (SAREC/SIDA)||European-Developing Countries Clinical Trials Partnership (EU/EDCTP)|JP 10800.006|Swedish Research Council||Swedish Heart and Lung Foundation (Oscar II Jubilee Foundation)||

    Available from: 2012-10-05 Created: 2012-10-05 Last updated: 2013-05-02
    4. Impact of helminth infection on the clinical presentation 1 of pulmonary tuberculosis
    Open this publication in new window or tab >>Impact of helminth infection on the clinical presentation 1 of pulmonary tuberculosis
    Show others...
    2013 (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Background: The effects of helminth infection on chronic infectious diseases such as HIV and tuberculosis (TB) merit further characterization. Thus, we assessed the baseline clinical characteristics of helminth infection in patients with active TB in a high endemic area.

    Methodology: Consecutive, newly diagnosed TB patients were recruited from three health institutions in the north Gondar administrative zone, Ethiopia. Structured questionnaires were used to collect socio-demographic and clinical characteristics. Additionally, the TB score, mid upper arm circumference, body mass index (BMI), BCG vaccination status, stool and sputum microscopy as well as HIV serology and CD4+T cells counts were evaluated.

    Results: A total of 377 pulmonary TB patients were included in the study. The helminth co infection rate was 33% (123/377) and the most prevalent parasite was Ascaris lumbricoides (53%, 65/123). The HIV co-infection rate was 29% (110/377). Seventy percent (77/110) of the HIV co-infected patients were on anti- retroviral therapy at the time of TB diagnosis. Helminth infection was more prevalent in HIV-negative TB patients compared to HIV-positive TB patients (p=0.025). Smoking and walking bare foot were independently associated to helminth infection in TB patients after adjusting for the influence of HIV. Other than increased eosinophilia, no other significant differences were observed between helminth positive and helminth negative TB patients in the clinical presentation including the TB score, CD4+T-cells, BMI or bacterial load.

    Conclusion: The clinical presentation of active pulmonary tuberculosis was not affected by helminth infection. Helminth infection was less frequent among HIV-positive TB patients and this finding merits further investigation.

    Keyword
    Tuberculosis, HIV, helminth, TB score, CD4, Ethiopia
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-91825 (URN)
    Available from: 2013-05-02 Created: 2013-05-02 Last updated: 2013-05-02Bibliographically approved
    5. Effects of albendazole treatment on the clinical outcome and immunological responses in patients with helminth infection and pulmonary tuberculosis: a randomized clinical trial
    Open this publication in new window or tab >>Effects of albendazole treatment on the clinical outcome and immunological responses in patients with helminth infection and pulmonary tuberculosis: a randomized clinical trial
    Show others...
    2013 (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Background: The impact of helminth infection on the host immune response to tuberculosis (TB) has been characterized in experimental models but less so in the clinical setting. The objective of this study was to investigate the impact of deworming on the clinical outcome and cell mediated immune response in active TB.

    Methods: Newly diagnosed pulmonary TB patients in Gondar, Ethiopia were examined for helminth infection. Helminth-positive TB patients (W+/TB) were randomized to albendazole (400mg X III per os) or placebo. The primary outcome was change in TB-score after 2 months, and secondary outcomes were sputum smear conversion at the 2nd month, and changes in chest x-ray pattern, CD4+ T-cell count, eosinophil count, IgE-levels and immunological responses after 3 months. In a subset of W+/TB, W-/TB patients and healthy controls, flow cytometry and ELISPOT assays were used to characterize the regulatory T-cell population (Tregs) and the frequency of PPD- stimulated IFN-γ, IL-5 and IL-10 producing peripheral blood mononuclear cells (PBMCs).

    Results: A total of 140 helminth co-infected TB patients were included with an HIV coinfection rate of 22.8 %. Following albendazole treatment of the W+/TB patients, there was a significant decrease in helminth infection compared to placebo (8% (4/49) vs. 48 % (22/46), p<0.001). No significant effect was observed for albendazole compared to placebo on the primary outcome as evaluated by the TB-score (5.6 ±2.87 vs. 5.87 ±2.54, p=0.59). Eosinophil counts decreased significantly in the albendazole group. In a subgroup analysis of helminthnegative patients following albendazole treatment versus placebo, the albendazole group showed a trend for lower levels of IL-10 producing cells at month three (p=0.08). At baseline, W+/TB patients had a significantly higher mean level of Tregs (% Tregs/CD4+) compared to W-/TB patients and helminth-positive community controls. Additionally, the frequency of IFN-γ, IL-5 and spontaneous IL-10 levels was increased in helminth-positive compared to helminth-negative TB patients.

    Conclusions: No significant effects on the clinical outcome as measured with the TB-score was detected after albendazole treatment of helminth-positive TB patients compared to placebo. However, significant changes were observed in specific immunological responses such as reduced eosinophil counts and a trend towards lower levels of IL-10 producing cells. At baseline, helminth co-infected TB patients exhibited an increased Treg response as well as an increased IL-5 and spontaneous IL-10 production.

    Keyword
    Regulatory T-cells, helminth, tuberculosis, albendazole, deworming, Ethiopia, HIV
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-91827 (URN)
    Available from: 2013-05-02 Created: 2013-05-02 Last updated: 2013-05-02Bibliographically approved
  • 67.
    Abate, Ebba
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Belayneh, Meseret
    University of Addis Ababa, Ethiopia .
    Gelaw, Aschalew
    University of Gondar, Ethiopia .
    Idh, Jonna
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Getachew, Assefa
    University of Gondar, Ethiopia .
    Alemu, Shitaye
    University of Gondar, Ethiopia .
    Diro, Ermias
    University of Gondar, Ethiopia .
    Fikre, Nigussu
    University of Addis Ababa, Ethiopia .
    Britton, Sven
    Karolinska Hospital, Sweden .
    Elias, Daniel
    University of So Denmark, Denmark .
    Aseffa, Abraham
    Armauer Hansen Research Institute, Ethiopia .
    Stendahl, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Schön, Thomas
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    The Impact of Asymptomatic Helminth Co-Infection in Patients with Newly Diagnosed Tuberculosis in North-West Ethiopia2012In: PLoS ONE, ISSN 1932-6203, Vol. 7, no 8Article in journal (Refereed)
    Abstract [en]

    Background: Areas endemic of helminth infection, tuberculosis (TB) and HIV are to a large extent overlapping. The aim of this study was to assess the impact of asymptomatic helminth infection on the immunological response among TB patients with and without HIV, their house hold contacts and community controls. less thanbrgreater than less thanbrgreater thanMethodology: Consecutive smear positive TB patients (n = 112), their household contacts (n = 71) and community controls (n = 112) were recruited in Gondar town, Ethiopia. Stool microscopy, HIV serology, serum IgE level, eosinophil and CD4 counts were performed and tuberculosis patients were followed up for 3 months after initiation of anti-TB treatment. less thanbrgreater than less thanbrgreater thanResults: Helminth co-infection rate was 29% in TB patients and 21% in both community control and household contacts (p = 0.3) where Ascaris lumbricoides was the most prevalent parasite. In TB patients the seroprevalence of HIV was 47% (53/112). Eosinophilia and elevated IgE level were significantly associated with asymptomatic helminth infection. During TB treatment, the worm infection rate of HIV+/TB patients declined from 31% (10/32) at week 0 to 9% (3/32) at week 2 of TB treatment, whereas HIV2/TB patients showed no change from baseline to week 2, 29% (13/45) vs. 22.2% (10/45). This trend was stable at week 8 and 12 as well. less thanbrgreater than less thanbrgreater thanConclusion: One third of smear positive TB patients were infected with helminths. Eosinophilia and elevated IgE level correlated with asymptomatic worm infection, indicating an effect on host immunity. The rate of worm infection declined during TB treatment in HIV+/TB co-infected patients whereas no decline was seen in HIV2/TB group.

  • 68.
    Abate, Ebba
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. University of Gondar, Ethiopia.
    Belayneh, Meseret
    University of Addis Ababa, Ethiopia.
    Idh, Jonna
    Vastervik Hospital, Sweden.
    Diro, Ermias
    University of Gondar, Ethiopia.
    Elias, Daniel
    University of Southern Denmark, Denmark.
    Britton, Sven
    Karolinska Hospital, Sweden.
    Aseffa, Abraham
    Armauer Hansen Research Institute, Ethiopia.
    Stendahl, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Schön, Thomas
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Kalmar County Hospital, Sweden.
    Asymptomatic Helminth Infection in Active Tuberculosis Is Associated with Increased Regulatory and Th-2 Responses and a Lower Sputum Smear Positivity2015In: PLoS Neglected Tropical Diseases, ISSN 1935-2727, E-ISSN 1935-2735, Vol. 9, no 8, e0003994Article in journal (Refereed)
    Abstract [en]

    Background The impact of intestinal helminth infection on the clinical presentation and immune response during active tuberculosis (TB) infection is not well characterized. Our aim was to investigate whether asymptomatic intestinal helminth infection alters the clinical signs and symptoms as well as the cell mediated immune responses in patients with active TB.

    Methodology Consecutive, newly diagnosed TB patients and healthy community controls (CCs) were recruited in North-west Ethiopia. TB-score, body mass index and stool samples were analyzed. Cells from HIV-negative TB patients (HIV-/TB) and from CCs were analyzed for regulatory T-cells (Tregs) and cytokine responses using flow cytometry and ELISPOT, respectively.

    Results A significantly higher ratio of helminth co-infection was observed in TB patients without HIV (Helm+/HIV-/TB) compared to HIV negative CCs, (40% (121/306) versus 28% (85/306), p = 0.003). Helm+/HIV-/TB patients showed significantly increased IL-5 secreting cells compared to Helm-/HIV-/TB (37 SFU (IQR:13-103) versus 2 SFU (1-50); p = 0.02, n = 30). Likewise, levels of absolute Tregs (9.4 (3.2-16.7) cells/mu l versus 2.4 (1.1-4.0) cells/mu l; p = 0.041) and IL-10 secreting cells (65 SFU (7-196) versus 1 SFU (0-31); p = 0.014) were significantly higher in Helm+/HIV-/TB patients compared to Helm-/HIV-/TB patients. In a multivariate analysis, a lower rate of sputum smear positivity for acid fast bacilli, lower body temperature, and eosinophilia were independently associated with helminth infection in TB patients.

    Conclusions Asymptomatic helminth infection is associated with increased regulatory T-cell and Th2-type responses and a lower rate of sputum smear positivity. Further studies are warranted to investigate the clinical and immunological impact of helminth infection in TB patients.

  • 69.
    Abate, Ebba
    et al.
    Gondar College of Medical and Health Sciences, Gondar University, Gondar, Ethiopia; Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
    Elias, Daniel
    University of Southern Denmark, Institute of Molecular Medicine, Department of cancer and inflammation, Odense, Denmark.
    Getachew, Assefa
    Gondar College of Medical and Health Sciences, Gondar University, Gondar, Ethiopia.
    Alemu, Shitaye
    Gondar College of Medical and Health Sciences, Gondar University, Gondar, Ethiopia.
    Diro, Ermias
    Department of Radiology, University of Gondar, Gondar, Ethiopia.
    Britton, Sven
    Department of Infectious Diseases, Karolinska Hospital, Stockholm, Sweden.
    Aseffa, Abraham
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
    Stendahl, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Schön, Thomas
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Effects of albendazole treatment on the clinical outcome and immunological responses in patients with helminth infection and pulmonary tuberculosis: a randomized clinical trial2013Manuscript (preprint) (Other academic)
    Abstract [en]

    Background: The impact of helminth infection on the host immune response to tuberculosis (TB) has been characterized in experimental models but less so in the clinical setting. The objective of this study was to investigate the impact of deworming on the clinical outcome and cell mediated immune response in active TB.

    Methods: Newly diagnosed pulmonary TB patients in Gondar, Ethiopia were examined for helminth infection. Helminth-positive TB patients (W+/TB) were randomized to albendazole (400mg X III per os) or placebo. The primary outcome was change in TB-score after 2 months, and secondary outcomes were sputum smear conversion at the 2nd month, and changes in chest x-ray pattern, CD4+ T-cell count, eosinophil count, IgE-levels and immunological responses after 3 months. In a subset of W+/TB, W-/TB patients and healthy controls, flow cytometry and ELISPOT assays were used to characterize the regulatory T-cell population (Tregs) and the frequency of PPD- stimulated IFN-γ, IL-5 and IL-10 producing peripheral blood mononuclear cells (PBMCs).

    Results: A total of 140 helminth co-infected TB patients were included with an HIV coinfection rate of 22.8 %. Following albendazole treatment of the W+/TB patients, there was a significant decrease in helminth infection compared to placebo (8% (4/49) vs. 48 % (22/46), p<0.001). No significant effect was observed for albendazole compared to placebo on the primary outcome as evaluated by the TB-score (5.6 ±2.87 vs. 5.87 ±2.54, p=0.59). Eosinophil counts decreased significantly in the albendazole group. In a subgroup analysis of helminthnegative patients following albendazole treatment versus placebo, the albendazole group showed a trend for lower levels of IL-10 producing cells at month three (p=0.08). At baseline, W+/TB patients had a significantly higher mean level of Tregs (% Tregs/CD4+) compared to W-/TB patients and helminth-positive community controls. Additionally, the frequency of IFN-γ, IL-5 and spontaneous IL-10 levels was increased in helminth-positive compared to helminth-negative TB patients.

    Conclusions: No significant effects on the clinical outcome as measured with the TB-score was detected after albendazole treatment of helminth-positive TB patients compared to placebo. However, significant changes were observed in specific immunological responses such as reduced eosinophil counts and a trend towards lower levels of IL-10 producing cells. At baseline, helminth co-infected TB patients exhibited an increased Treg response as well as an increased IL-5 and spontaneous IL-10 production.

  • 70.
    Abate, Ebba
    et al.
    Gondar College of Medical and Health Sciences, Gondar University, Gondar, Ethiopia; Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
    Idh, Jonna
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Belayneh, Meseret
    School of Medical Laboratory Sciences, Medical Faculty, Addis Ababa University, Addis Ababa.
    Getachew, Assefa
    Gondar College of Medical and Health Sciences, Gondar University, Gondar, Ethiopia.
    Alemu, Shitaye
    Gondar College of Medical and Health Sciences, Gondar University, Gondar, Ethiopia.
    Diro, Ermias
    Department of Radiology, University of Gondar, Gondar, Ethiopia.
    Britton, Sven
    Department of Infectious Diseases, Karolinska Hospital, Stockholm, Sweden.
    Elias, Daniel
    University of Southern Denmark, Institute of Molecular Medicine, Department of cancer and inflammation, Odense, Denmark.
    Aseffa, Abraham
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
    Stendahl, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Schön, Thomas
    Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
    Impact of helminth infection on the clinical presentation 1 of pulmonary tuberculosis2013Manuscript (preprint) (Other academic)
    Abstract [en]

    Background: The effects of helminth infection on chronic infectious diseases such as HIV and tuberculosis (TB) merit further characterization. Thus, we assessed the baseline clinical characteristics of helminth infection in patients with active TB in a high endemic area.

    Methodology: Consecutive, newly diagnosed TB patients were recruited from three health institutions in the north Gondar administrative zone, Ethiopia. Structured questionnaires were used to collect socio-demographic and clinical characteristics. Additionally, the TB score, mid upper arm circumference, body mass index (BMI), BCG vaccination status, stool and sputum microscopy as well as HIV serology and CD4+T cells counts were evaluated.

    Results: A total of 377 pulmonary TB patients were included in the study. The helminth co infection rate was 33% (123/377) and the most prevalent parasite was Ascaris lumbricoides (53%, 65/123). The HIV co-infection rate was 29% (110/377). Seventy percent (77/110) of the HIV co-infected patients were on anti- retroviral therapy at the time of TB diagnosis. Helminth infection was more prevalent in HIV-negative TB patients compared to HIV-positive TB patients (p=0.025). Smoking and walking bare foot were independently associated to helminth infection in TB patients after adjusting for the influence of HIV. Other than increased eosinophilia, no other significant differences were observed between helminth positive and helminth negative TB patients in the clinical presentation including the TB score, CD4+T-cells, BMI or bacterial load.

    Conclusion: The clinical presentation of active pulmonary tuberculosis was not affected by helminth infection. Helminth infection was less frequent among HIV-positive TB patients and this finding merits further investigation.

  • 71.
    Abbas, Ashraf H.
    et al.
    Plastic Surgery Unit, Surgery Dept., Suez Canal University, Ismailia, Egypt.
    Elmasry, Moustafa
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Plastic Surgery Unit, Surgery Dept., Suez Canal University, Ismailia, Egypt.
    Steinvall, Ingrid
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Adly, Osama A.
    Plastic Surgery Unit, Surgery Dept., Suez Canal University, Ismailia, Egypt.
    Elbadawy, Mohamed A.
    Plastic Surgery Unit, Surgery Dept., Suez Canal University, Ismailia, Egypt.
    Moati, Taha Ali
    General Surgery department, Suez Canal University, Ismailia, Egypt.
    Sjöberg, Folke
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Anaesthesiology and Intensive Care in Linköping.
    Aesthetic Outcome After Reconstruction of Complex SoftTissue Defects with Free Antero-Lateral Thigh Flap UsingSimple Equipment2015In: Journal of surgery, ISSN 2330-0914, Vol. 3, no 2-1, 36-41 p.Article in journal (Refereed)
    Abstract [en]

    Aim: We aimed to assess the aesthetic outcome of surgical reconstruction by free ALT flap using binocular single-refraction magnifying glasses and a modified post- operative surveillance protocol. Methods: 16 patients were operated for free antero-lateral thigh flap to reconstruct complex soft tissue defects with a close clinical follow up protocol for post operative care depending on the attending personnel in the Plastic surgery unit, Suez Canal University hospital, Ismailia, Egypt. Aesthetic outcome was assessed using a questionnaire based on Posch et al. 2005, including the following items colour, contour, presence of hair, overall appearance and donor site scar. Results: The patients’ assessed aesthetic outcome was acceptable in majority of the cases; median score was 4 for all assessed items. Complete flap loss occurred in one case, other complications as arterial thrombosis and hematomas and infection were detected and managed accordingly with flap salvage in the 3 complicated cases. Conclusion: The result suggests that the proposed protocol is sufficient as an alternative. The aesthetic outcome assessed by the patient and the failure rate was in line with other studies.

  • 72.
    Abbas, Muhammad
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    On the Implementation of Integer and Non-Integer Sampling Rate Conversion2012Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The main focus in this thesis is on the aspects related to the implementation of integer and non-integer sampling rate conversion (SRC). SRC is used in many communication and signal processing applications where two signals or systems having different sampling rates need to be interconnected. There are two basic approaches to deal with this problem. The first is to convert the signal to analog and then re-sample it at the desired rate. In the second approach, digital signal processing techniques are utilized to compute values of the new samples from the existing ones. The former approach is hardly used since the latter one introduces less noise and distortion. However, the implementation complexity for the second approach varies for different types of conversion factors. In this work, the second approach for SRC is considered and its implementation details are explored. The conversion factor in general can be an integer, a ratio of two integers, or an irrational number. The SRC by an irrational numbers is impractical and is generally stated for the completeness. They are usually approximated by some rational factor.

    The performance of decimators and interpolators is mainly determined by the filters, which are there to suppress aliasing effects or removing unwanted images. There are many approaches for the implementation of decimation and interpolation filters, and cascaded integrator comb (CIC) filters are one of them. CIC filters are most commonly used in the case of integer sampling rate conversions and often preferred due to their simplicity, hardware efficiency, and relatively good anti-aliasing (anti-imaging) characteristics for the first (last) stage of a decimation (interpolation). The multiplierless nature, which generally yields to low power consumption, makes CIC filters well suited for performing conversion at higher rate. Since these filters operate at the maximum sampling frequency, therefore, are critical with respect to power consumption. It is therefore necessary to have an accurate and efficient ways and approaches that could be utilized to estimate the power consumption and the important factors that are contributing to it. Switching activity is one such factor. To have a high-level estimate of dynamic power consumption, switching activity equations in CIC filters are derived, which may then be used to have an estimate of the dynamic power consumption. The modeling of leakage power is also included, which is an important parameter to consider since the input sampling rate may differ several orders of magnitude. These power estimates at higher level can then be used as a feed-back while exploring multiple alternatives.

    Sampling rate conversion is a typical example where it is required to determine the values between existing samples. The computation of a value between existing samples can alternatively be regarded as delaying the underlying signal by a fractional sampling period. The fractional-delay filters are used in this context to provide a fractional-delay adjustable to any desired value and are therefore suitable for both integer and non-integer factors. The structure that is used in the efficient implementation of a fractional-delay filter is know as Farrow structure or its modifications. The main advantage of the Farrow structure lies in the fact that it consists of fixed finite-impulse response (FIR) filters and there is only one adjustable fractional-delay parameter, used to evaluate a polynomial with the filter outputs as coefficients. This characteristic of the Farrow structure makes it a very attractive structure for the implementation. In the considered fixed-point implementation of the Farrow structure, closed-form expressions for suitable word lengths are derived based on scaling and round-off noise. Since multipliers share major portion of the total power consumption, a matrix-vector multiple constant multiplication approach is proposed to improve the multiplierless implementation of FIR sub-filters.

    The implementation of the polynomial part of the Farrow structure is investigated by considering the computational complexity of different polynomial evaluation schemes. By considering the number of operations of different types, critical path, pipelining complexity, and latency after pipelining, high-level comparisons are obtained and used to short list the suitable candidates. Most of these evaluation schemes require the explicit computation of higher order power terms. In the parallel evaluation of powers, redundancy in computations is removed by exploiting any possible sharing at word level and also at bit level. As a part of this, since exponents are additive under multiplication, an ILP formulation for the minimum addition sequence problem is proposed.

    List of papers
    1. Power Estimation of Recursive and Non-Recursive CIC Filters Implemented in Deep-Submicron Technology
    Open this publication in new window or tab >>Power Estimation of Recursive and Non-Recursive CIC Filters Implemented in Deep-Submicron Technology
    2010 (English)In: Proceedings of International Conference on Green Circuits and Systems (ICGCS), 2010, Date: 21-23 June, 2010, IEEE , 2010, 221-225 p.Conference paper, Published paper (Refereed)
    Abstract [en]

    The power modeling of different realizations of cascaded integrator-comb (CIC) decimation filters has been a subject of several recent works. In this work we have extended these with modeling of leakage power, which is an important factor since the input sample rate may differ several orders of magnitude. Furthermore, we have pointed out the importance of the input wordlength on the comparison of recursive and nonrecursive implementations.

    Place, publisher, year, edition, pages
    IEEE, 2010
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-70451 (URN)10.1109/ICGCS.2010.5543063 (DOI)978-1-4244-6877-5 (ISBN)978-1-4244-6876-8 (ISBN)
    Conference
    International Conference on Green Circuits and Systems (ICGCS), June 21–23, Shanghai, China
    Available from: 2011-09-20 Created: 2011-09-08 Last updated: 2015-03-11Bibliographically approved
    2. Switching Activity Estimation of CIC Filter Integrators
    Open this publication in new window or tab >>Switching Activity Estimation of CIC Filter Integrators
    2010 (English)In: Proceedings of Asia Pacific Conference on Postgraduate Research in Microelectronics and Electronics (PrimeAsia), 2010, Date:22-24 Sept. 2010, IEEE , 2010, 21-24 p.Conference paper, Published paper (Refereed)
    Abstract [en]

    In this work, a method for estimation of the switching activity in integrators is presented. To achieve low power, it is always necessary to develop accurate and efficient methods to estimate the switching activity. The switching activities are then used to estimate the power consumption. In our work, the switching activity is first estimated for the general purpose integrators and then it is extended for the estimation of switching activity in cascaded integrators in CIC filters.

    Place, publisher, year, edition, pages
    IEEE, 2010
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-70452 (URN)10.1109/PRIMEASIA.2010.5604971 (DOI)978-1-4244-6736-5 (ISBN)978-1-4244-6735-8 (ISBN)
    Conference
    Asia Pacific Conference on Postgraduate Research in Microelectronics and Electronics (PrimeAsia), 22-24 September, Shanghai, China
    Note
    ©2010 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. MUHAMMAD ABBAS and Oscar Gustafsson, Switching Activity Estimation of CIC Filter Integrators, 2010, Asia Pacific Conf. on Postgraduate Research in Microelectronics and Electronics, Shanghai, China. http://dx.doi.org/10.1109/PRIMEASIA.2010.5604971 Available from: 2011-09-20 Created: 2011-09-08 Last updated: 2015-03-11Bibliographically approved
    3. Scaling of fractional delay filters based on the Farrow structure
    Open this publication in new window or tab >>Scaling of fractional delay filters based on the Farrow structure
    2009 (English)In: Proceedings of IEEE International Symposium on Circuits and Systems, 2009. ISCAS 2009, Piscataway: IEEE , 2009, 489-492 p.Conference paper, Published paper (Refereed)
    Abstract [en]

    In this work we consider scaling of fractional delay filters using the Farrow structure. Based on the observation that the subfilters approximate the Taylor expansion of a differentiator, we derive estimates of the L2-norm scaling values at the outputs of each subfilter as well as at the inputs of each delay multiplier. The scaling values can then be used to derive suitable wordlengths in a fixed-point implementation.

    Place, publisher, year, edition, pages
    Piscataway: IEEE, 2009
    National Category
    Signal Processing
    Identifiers
    urn:nbn:se:liu:diva-51070 (URN)10.1109/ISCAS.2009.5117792 (DOI)000275929800123 ()978-1-4244-3827-3 (ISBN)
    Conference
    IEEE International Symposium on Circuits and Systems, 24-27 May 2009, Taipei,Taiwan
    Available from: 2009-10-15 Created: 2009-10-15 Last updated: 2015-03-11Bibliographically approved
    4. Computational and Implementation Complexity of Polynomial Evaluation Schemes
    Open this publication in new window or tab >>Computational and Implementation Complexity of Polynomial Evaluation Schemes
    2011 (English)In: Proceedings of NORCHIP, 2011 Date:14-15 Nov. 2011, IEEE conference proceedings, 2011, 1-6 p.Conference paper, Published paper (Refereed)
    Abstract [en]

    In this work, we consider the computational complexity of different polynomial evaluation schemes. By considering the number of operations of different types, critical path, pipelining complexity, and latency after pipelining, high-level comparisons are obtained. These can then be used to short list suitable candidates for an implementation given the specifications. Not only multiplications are considered, but they are divided into data-data multiplications, squarers, and data-coefficient multiplications, as the latter can be optimized depending on implementation architecture and application.

    Place, publisher, year, edition, pages
    IEEE conference proceedings, 2011
    Keyword
    Adders, Computer architecture, Delay, Filtering algorithms, ISO, Pipeline processing, Polynomials
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-73935 (URN)10.1109/NORCHP.2011.6126735 (DOI)978-1-4577-0515-1 (ISBN)978-1-4577-0514-4 (ISBN)
    Conference
    NORCHIP 2011. The Nordic Microelectronics event, 29th Norchip Conference 14-15 November 2011, Lund, Sweden
    Available from: 2012-01-17 Created: 2012-01-17 Last updated: 2015-03-11Bibliographically approved
    5. Low-Complexity Parallel Evaluation of Powers Exploiting Bit-Level Redundancy
    Open this publication in new window or tab >>Low-Complexity Parallel Evaluation of Powers Exploiting Bit-Level Redundancy
    2010 (English)In: Conference Record of the Forty Fourth Asilomar Conference on Signals, Systems and Computers (ASILOMAR), 2010, 7-10 Nov. 2010 / [ed] Michael B. Matthews, Washington, DC, USA: IEEE Computer Society , 2010, 1168-1172 p.Conference paper, Published paper (Refereed)
    Abstract [en]

    In this work, we investigate the problem of computing any requested set of power terms in parallel using summations trees. This problem occurs in applications like polynomial approximation, Farrow filters (polynomial evaluation part) etc. In the proposed technique, the partial product of each power term is initially computed independently. A redundancy check is then made in each and among all partial products matrices at bit level. The redundancy here relates to the fact that same three partial products may be present in more than one columns, and, hence, can be mapped to the same full adder. The proposed algorithm is tested for different sets of powers and wordlengths to exploit the sharing potential.

    Place, publisher, year, edition, pages
    Washington, DC, USA: IEEE Computer Society, 2010
    Series
    Asilomar Conference on Signals, Systems and Computers. Conference Record, ISSN 1058-6393
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-70453 (URN)10.1109/ACSSC.2010.5757714 (DOI)978-1-4244-9722-5 (ISBN)
    Conference
    Signals, Systems and Computers (ASILOMAR), 2010, 7-10 Nov. 2010 , Pacific Grove, CA, USA
    Available from: 2011-09-20 Created: 2011-09-08 Last updated: 2015-03-11Bibliographically approved
    6. Integer Linear Programming Modeling of Addition Sequences With Additional Constraints for Evaluation of Power Terms
    Open this publication in new window or tab >>Integer Linear Programming Modeling of Addition Sequences With Additional Constraints for Evaluation of Power Terms
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    In this work, an integer linear programming (ILP) based model is proposed for the computation of a minimal cost addition sequence for a given set of integers. Since exponents are additive under multiplication, the minimal length addition sequence will provide an optimal solution for the evaluation of a requested set of power terms. This in turn finds application in, e.g., window-based exponentiation for cryptography and polynomial evaluation. Not only is an optimal model proposed, the model is extended to consider different costs for multipliers and squarers as well as controlling the depth of the resulting addition sequence.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-73936 (URN)
    Available from: 2012-01-17 Created: 2012-01-17 Last updated: 2015-03-11Bibliographically approved
    7. Switching Activity Estimation of DDFS Phase Accumulators
    Open this publication in new window or tab >>Switching Activity Estimation of DDFS Phase Accumulators
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    In this letter, equations for the one’s probability and switching activities for direct digital frequency synthesis (DDFS) phase accumulators are derived. These results are useful for obtaining good accuracy estimated of both leakage and dynamic power consumption for the phase accumulator and the phase-to-magnitude converter.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-73937 (URN)
    Available from: 2012-01-17 Created: 2012-01-17 Last updated: 2015-03-11Bibliographically approved
  • 73.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Integer Linear Programming Modeling of Addition Sequences With Additional Constraints for Evaluation of Power TermsManuscript (preprint) (Other academic)
    Abstract [en]

    In this work, an integer linear programming (ILP) based model is proposed for the computation of a minimal cost addition sequence for a given set of integers. Since exponents are additive under multiplication, the minimal length addition sequence will provide an optimal solution for the evaluation of a requested set of power terms. This in turn finds application in, e.g., window-based exponentiation for cryptography and polynomial evaluation. Not only is an optimal model proposed, the model is extended to consider different costs for multipliers and squarers as well as controlling the depth of the resulting addition sequence.

  • 74.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Switching Activity Estimation of DDFS Phase AccumulatorsManuscript (preprint) (Other academic)
    Abstract [en]

    In this letter, equations for the one’s probability and switching activities for direct digital frequency synthesis (DDFS) phase accumulators are derived. These results are useful for obtaining good accuracy estimated of both leakage and dynamic power consumption for the phase accumulator and the phase-to-magnitude converter.

  • 75.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Computational and Implementation Complexity of Polynomial Evaluation Schemes2011In: Proceedings of NORCHIP, 2011 Date:14-15 Nov. 2011, IEEE conference proceedings, 2011, 1-6 p.Conference paper (Refereed)
    Abstract [en]

    In this work, we consider the computational complexity of different polynomial evaluation schemes. By considering the number of operations of different types, critical path, pipelining complexity, and latency after pipelining, high-level comparisons are obtained. These can then be used to short list suitable candidates for an implementation given the specifications. Not only multiplications are considered, but they are divided into data-data multiplications, squarers, and data-coefficient multiplications, as the latter can be optimized depending on implementation architecture and application.

  • 76.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Switching Activity Estimation of CIC Filter Integrators2010In: Proceedings of Asia Pacific Conference on Postgraduate Research in Microelectronics and Electronics (PrimeAsia), 2010, Date:22-24 Sept. 2010, IEEE , 2010, 21-24 p.Conference paper (Refereed)
    Abstract [en]

    In this work, a method for estimation of the switching activity in integrators is presented. To achieve low power, it is always necessary to develop accurate and efficient methods to estimate the switching activity. The switching activities are then used to estimate the power consumption. In our work, the switching activity is first estimated for the general purpose integrators and then it is extended for the estimation of switching activity in cascaded integrators in CIC filters.

  • 77.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Blad, Anton
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Low-Complexity Parallel Evaluation of Powers Exploiting Bit-Level Redundancy2010In: Conference Record of the Forty Fourth Asilomar Conference on Signals, Systems and Computers (ASILOMAR), 2010, 7-10 Nov. 2010 / [ed] Michael B. Matthews, Washington, DC, USA: IEEE Computer Society , 2010, 1168-1172 p.Conference paper (Refereed)
    Abstract [en]

    In this work, we investigate the problem of computing any requested set of power terms in parallel using summations trees. This problem occurs in applications like polynomial approximation, Farrow filters (polynomial evaluation part) etc. In the proposed technique, the partial product of each power term is initially computed independently. A redundancy check is then made in each and among all partial products matrices at bit level. The redundancy here relates to the fact that same three partial products may be present in more than one columns, and, hence, can be mapped to the same full adder. The proposed algorithm is tested for different sets of powers and wordlengths to exploit the sharing potential.

  • 78.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Johansson, Håkan
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    On the Fixed-Point Implementation of Fractional-Delay Filters Based on the Farrow Structure2013In: IEEE Transactions on Circuits and Systems Part 1: Regular Papers, ISSN 1549-8328, E-ISSN 1558-0806, Vol. 60, no 4, 926-937 p.Article in journal (Refereed)
    Abstract [en]

    In this paper, the fixed-point implementation of adjustable fractional-delay filters using the Farrow structure is considered. Based on the observation that the sub-filters approximate differentiators, closed-form expressions for the L-2-norm scaling values at the outputs of each sub-filter as well as at the inputs of each delay multiplier are derived. The scaling values can then be used to derive suitable word lengths by also considering the round-off noise analysis and optimization. Different approaches are proposed to derive suitable word lengths including one based on integer linear programming, which always gives an optimal allocation. Finally, a new approach for multiplierless implementation of the sub-filters in the Farrow structure is suggested. This is shown to reduce register complexity and, for most word lengths, require less number of adders and subtracters when compared to existing approaches.

  • 79.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Johansson, Håkan
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Scaling of fractional delay filters based on the Farrow structure2009In: Proceedings of IEEE International Symposium on Circuits and Systems, 2009. ISCAS 2009, Piscataway: IEEE , 2009, 489-492 p.Conference paper (Refereed)
    Abstract [en]

    In this work we consider scaling of fractional delay filters using the Farrow structure. Based on the observation that the subfilters approximate the Taylor expansion of a differentiator, we derive estimates of the L2-norm scaling values at the outputs of each subfilter as well as at the inputs of each delay multiplier. The scaling values can then be used to derive suitable wordlengths in a fixed-point implementation.

  • 80.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Wanhammar, Lars
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Power Estimation of Recursive and Non-Recursive CIC Filters Implemented in Deep-Submicron Technology2010In: Proceedings of International Conference on Green Circuits and Systems (ICGCS), 2010, Date: 21-23 June, 2010, IEEE , 2010, 221-225 p.Conference paper (Refereed)
    Abstract [en]

    The power modeling of different realizations of cascaded integrator-comb (CIC) decimation filters has been a subject of several recent works. In this work we have extended these with modeling of leakage power, which is an important factor since the input sample rate may differ several orders of magnitude. Furthermore, we have pointed out the importance of the input wordlength on the comparison of recursive and nonrecursive implementations.

  • 81.
    Abbas, Muhammad Hassan
    et al.
    Linköping University, Department of Computer and Information Science.
    Khan, Mati-ur-Rehman
    Linköping University, Department of Computer and Information Science.
    Correlational Analysis of Drivers Personality Traits and Styles in a Distributed Simulated Driving Environment2007Independent thesis Basic level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In this thesis report we conducted research study on driver's behavior in T-Intersections using simulated environment. This report describes and discusses correlation analysis of driver's personality traits and style while driving at T-Intersections.

    The experiments were performed on multi user driving simulator under controlled settings, at Linköping University. A total of forty-eight people participated in the study and were divided into groups of four, all driving in the same simulated world.

    During the experiments participants were asked to fill a series of well-known self-report questionnaires. We evaluated questionnaires to get the insight in driver's personality traits and driving style. The self-report questionnaires consist of Schwartz's configural model of 10 values types and NEO-five factor inventory. Also driver's behavior was studied with the help of questionnaires based on driver's behavior, style, conflict avoidance, time horizon and tolerance of uncertainty. Then these 10 Schwartz's values are correlated with the other questionnaires to give the detail insight of the driving habits and personality traits of the drivers.

  • 82.
    Abbas, Muhammad
    et al.
    Linköping University, Department of Electrical Engineering. Linköping University, The Institute of Technology.
    Qureshi, Fahad
    Linköping University, Department of Electrical Engineering. Linköping University, The Institute of Technology.
    Ullah Sheikh, Zaka
    Linköping University, Department of Electrical Engineering. Linköping University, The Institute of Technology.
    Gustafsson, Oscar
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Johansson, Håkan
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Johansson, Kenny
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Comparison of Multiplierless Implementation of Nonlinear-Phase Versus Linear-Phase FIR filters2008Conference paper (Refereed)
    Abstract [en]

    FIR filters are often used because of their linear-phase response. However, there are certain applications where the linear-phase property is not required, such as signal energy estimation, but IIR filters can not be used due to the limitation of sample rate imposed by the recursive algorithm. In this work, we discuss multiplierless implementation of minimum order, and therefore nonlinear-phase, FIR filters and compare it to the linear-phase counterpart.

  • 83.
    Abbas, Qaisar
    Uppsala universitet, Avdelningen för teknisk databehandling.
    Weak Boundary and Interface Procedures for Wave and Flow Problems2011Doctoral thesis, monograph (Other academic)
    Abstract [en]

    In this thesis, we have analyzed the accuracy and stability aspects of weak boundary and interface conditions (WBCs) for high order finite difference methods on Summations-By-Parts (SBP) form. The numerical technique has been applied to wave propagation and flow problems.

    The advantage of WBCs over strong boundary conditions is that stability of the numerical scheme can be proven. The boundary procedures in the advection-diffusion equation for a boundary layer problem is analyzed. By performing Navier-Stokes calculations, it is shown that most of the conclusions from the model problem carries over to the fully nonlinear case.

    The work was complemented to include the new idea of using WBCs on multiple grid points in a region, where the data is known, instead of at a single point. It was shown that we can achieve high accuracy, an increased rate of convergence to steady-state and non-reflecting boundary conditions by using this approach.

    Using the SBP technique and WBCs, we have worked out how to construct conservative and energy stable hybrid schemes for shocks using two different approaches. In the first method, we combine a high order finite difference scheme with a second order MUSCL scheme. In the second method, a procedure to locally change the order of accuracy of the finite difference schemes is developed. The main purpose is to obtain a higher order accurate scheme in smooth regions and a low order non-oscillatory scheme in the vicinity of shocks.

    Furthermore, we have analyzed the energy stability of the MUSCL scheme, by reformulating the scheme in the framework of SBP and artificial dissipation operators. It was found that many of the standard slope limiters in the MUSCL scheme do not lead to a negative semi-definite dissipation matrix, as required to get pointwise stability.

    Finally, high order simulations of shock diffracting over a convex wall with two facets were performed. The numerical study is done for a range of Reynolds numbers. By monitoring the velocities at the solid wall, it was shown that the computations were resolved in the boundary layer. Schlieren images from the computational results were obtained which displayed new interesting flow features.

  • 84.
    Abbas, Qaisar
    et al.
    Uppsala universitet, Avdelningen för teknisk databehandling.
    Nordström, Jan
    Uppsala universitet, Avdelningen för teknisk databehandling.
    Weak versus strong no-slip boundary conditions for the Navier-Stokes equations2010In: Engineering Applications of Computational Fluid Mechanics, ISSN 1994-2060, Vol. 4, 29-38 p.Article in journal (Refereed)
  • 85.
    Abbas, Qaisar
    et al.
    Uppsala universitet, Avdelningen för teknisk databehandling.
    Nordström, Jan
    Uppsala universitet, Avdelningen för teknisk databehandling.
    Weak versus Strong No-Slip Boundary Conditions for the Navier-Stokes Equations2008In: Proc. 6th South African Conference on Computational and Applied Mechanics, South African Association for Theoretical and Applied Mechanics , 2008, 52-62 p.Conference paper (Other academic)
  • 86.
    Abbas, Qaisar
    et al.
    Uppsala universitet, Avdelningen för teknisk databehandling.
    van der Weide, Edwin
    Nordström, Jan
    Uppsala universitet, Avdelningen för teknisk databehandling.
    Accurate and stable calculations involving shocks using a new hybrid scheme2009In: Proc. 19th AIAA CFD Conference, AIAA , 2009Conference paper (Refereed)
  • 87.
    Abbas, Qaisar
    et al.
    Uppsala universitet, Avdelningen för teknisk databehandling.
    van der Weide, Edwin
    Faculty of Engineering Technology, University of Twente, AE Enschede, The Netherlands.
    Nordström, Jan
    Uppsala universitet, Avdelningen för teknisk databehandling.
    Energy Stability of the MUSCL Scheme2010In: Proc. 7th South African Conference on Computational and Applied Mechanics, South African Association for Theoretical and Applied Mechanics , 2010, 65:1-8 p.Conference paper (Other academic)
  • 88.
    Abbas, Qaisar
    et al.
    Uppsala universitet, Avdelningen för teknisk databehandling.
    van der Weide, Edwin
    Nordström, Jan
    Uppsala universitet, Avdelningen för teknisk databehandling.
    Energy stability of the MUSCL scheme2010In: Numerical Mathematics and Advanced Applications: 2009, Berlin: Springer-Verlag , 2010, 61-68 p.Conference paper (Refereed)
  • 89.
    Abbasi, Mazhar Ali
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    The synthesis, characterization and device fabrication of ZnO, NiO and their composite nanostructures2014Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Electronics industry has been revolutionized since last few decades because of the fabrication of electronic devices by using nanoscale based materials. But the more innovative feature in the electronic devices is the use of transparent materials, which makes the transparent electronic devices as one of the most interesting research field in nanoscience and nano-technology now a days. In order to have high performance electronic devices based on the wide band gap compound semiconductors, a selection of right transparent material is crucial step. Among all the transparent metal oxides, ZnO is one of the potential candidates due to the ease in the synthesis process, wide bandgap of 3.37 eV, a high exciton binding energy of 60 meV and diverse morphologies. Since p-type ZnO based nanodevices are still difficult to fabricate due to the instability and unreliability of p-type ZnO nanomaterial, therefore several p-type semiconductors are used for the development of p-n junctions. Among those NiO is suitable p-type compound semiconductor to make p-n junction with ZnO because of its wide band gap of 3.7 eV and environment friendly conditions for its synthesis. Keeping these attractive properties of n-type ZnO and p-type NiO, the synthesis of composite nanostructures of these two transparent oxides and fabrication of their electronic devices is presented in this dissertation work.

    I started my work with the synthesis of ZnO nanostructures focusing on the effect of different anions of zinc salts on the morphology and crystallinity of ZnO nanostructures. Then I grow honey-comb like NiO nanostructures on 3D nickel foam and used these nanostructures for the detection of Zinc ion. After that synthesized NiO and ZnO based composite nanostructures and characterized them, having main focus on the luminescence properties of ZnO when decorated with NiO nanostructures. The composite nanostructures of p-type NiO and n-type ZnO showed enhancement in the luminescence properties. Since pn junction is the back bone of electronic devices so working on the designing of band alignment along with the current transport properties of p-type NiO/n-type ZnO composite structures, an attempt was put forwarded to explain the phenomenon of these compound semiconducting materials. Different devices based on these two compound semiconducting materials are fabricated and designed in the present dissertation work, however still more work is required to improve the efficiency of devices like LEDs and UV detectors.

    List of papers
    1. Anions effect on the low temperature growth of ZnO nanostructures
    Open this publication in new window or tab >>Anions effect on the low temperature growth of ZnO nanostructures
    Show others...
    2012 (English)In: Vacuum, ISSN 0042-207X, E-ISSN 1879-2715, Vol. 86, no 12, 1998-2001 p.Article in journal (Refereed) Published
    Abstract [en]

    Seed mediated aqueous chemical growth (ACG) route was used for the growth of ZnO nanostructures on Si substrate in four different growth mediums. The growth medium has shown to affect the morphology and the size of the different nanostructures. We observed that the medium containing zinc nitrate anions yields the nanorods, in a medium containing zinc acetate anions nano-candles are obtained. While in a medium containing zinc chloride anions ZnO nano-discs were obtained and in a medium containing zinc sulfate anions nano-flakes are achieved. Growth in these different mediums has also shown effect on the optical emission characteristics of the different ZnO nanostructures.

    Place, publisher, year, edition, pages
    Elsevier, 2012
    Keyword
    ZnO, Chemical growth, Nanostructures, Optical properties
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-84909 (URN)10.1016/j.vacuum.2012.05.020 (DOI)000308672000041 ()
    Available from: 2012-10-26 Created: 2012-10-26 Last updated: 2014-01-17
    2. Potentiometric Zinc Ion Sensor Based on Honeycomb-Like NiO Nanostructures
    Open this publication in new window or tab >>Potentiometric Zinc Ion Sensor Based on Honeycomb-Like NiO Nanostructures
    Show others...
    2012 (English)In: Sensors, ISSN 1424-8220, Vol. 12, no 11, 15424-15437 p.Article in journal (Refereed) Published
    Abstract [en]

    In this study honeycomb-like NiO nanostructures were grown on nickel foam by a simple hydrothermal growth method. The NiO nanostructures were characterized by field emission electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM) and X-ray diffraction (XRD) techniques. The characterized NiO nanostructures were uniform, dense and polycrystalline in the crystal phase. In addition to this, the NiO nanostructures were used in the development of a zinc ion sensor electrode by functionalization with the highly selective zinc ion ionophore 12-crown-4. The developed zinc ion sensor electrode has shown a good linear potentiometric response for a wide range of zinc ion concentrations, ranging from 0.001 mM to 100 mM, with sensitivity of 36 mV/decade. The detection limit of the present zinc ion sensor was found to be 0.0005 mM and it also displays a fast response time of less than 10 s. The proposed zinc ion sensor electrode has also shown good reproducibility, repeatability, storage stability and selectivity. The zinc ion sensor based on the functionalized NiO nanostructures was also used as indicator electrode in potentiometric titrations and it has demonstrated an acceptable stoichiometric relationship for the determination of zinc ion in unknown samples. The NiO nanostructures-based zinc ion sensor has potential for analysing zinc ion in various industrial, clinical and other real samples.

    Place, publisher, year, edition, pages
    MDPI, 2012
    Keyword
    honeycomb NiO nanostructures, potentiometric response, ion selective electrode, selectivity, selective ionophore
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-86653 (URN)10.3390/s121115424 (DOI)000311429500060 ()
    Available from: 2012-12-20 Created: 2012-12-20 Last updated: 2014-01-17
    3. Decoration of ZnO nanorods with coral reefs like NiO nanostructures by the hydrothermal growth method and their luminescence study
    Open this publication in new window or tab >>Decoration of ZnO nanorods with coral reefs like NiO nanostructures by the hydrothermal growth method and their luminescence study
    Show others...
    2014 (English)In: Materials, ISSN 1996-1944, Vol. 7, no 1, 430-440 p.Article in journal (Refereed) Published
    Abstract [en]

    Composite nanostructures of coral reefs like p-type NiO on n-type ZnO nanorods have been decorate on fluorine-doped tin oxide glass substrates by the hydrothermal growth. Structural characterization was performed by field emission scanning electron microscopy,  high-resolution transmission electron microscopy and X-ray diffraction techniques. This investigation has shown that the adopted synthesis has led to high crystalline quality nanostructures. Morphological study shows that the coral reefs like nanostructures are densely packed on the ZnO nanorods. Cathodoluminescence (CL) spectra for the synthesized composite nanostructures were dominated by a near band gap emission at 380 nm and by a broad interstitial defect related luminescence centered at ~630 nm. Spatially resolved CL images reveal that the luminescence originates mainly from the ZnO nanorods.

    Place, publisher, year, edition, pages
    MDPI, 2014
    Keyword
    ZnO nanorods; NiO nanostructure; composite nanostructures; defect states; cathodoluminescent
    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:liu:diva-103339 (URN)10.3390/ma7010430 (DOI)000336088500030 ()
    Available from: 2014-01-17 Created: 2014-01-17 Last updated: 2016-08-31Bibliographically approved
    4. The determination of valence band offset and the current transport properties of the p-NiO/n-ZnO heterojunction
    Open this publication in new window or tab >>The determination of valence band offset and the current transport properties of the p-NiO/n-ZnO heterojunction
    Show others...
    2013 (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The electron transport in the electronic devices has significant influence on the device performance, thus current transport properties determination is highly demanded for a particular device. Herein, we report the facile hydrothermal growth method based fabrication of p-NiO/n-ZnO heterojunction. The material characterization was performed by scanning electron microscopy, X-ray diffraction, transmission electron microscopy and X-ray photo electron spectroscopy. These techniques provided the good crystal quality, pure phase of p-NiO and n-ZnO nanostructures respectively. The measured valance band offset of composite nanostructure is 2.25 eV and conduction band offset was found to be 2.58 eV. The current transport properties of the fabricated p-n junction are governed by three different I-V regions. The impedance spectroscopy was used for the determination of the role of grain boundaries at the interface.

    Keyword
    Zinc oxide, nickel oxide, heterojunction, diode, current transport properties
    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:liu:diva-103340 (URN)
    Available from: 2014-01-17 Created: 2014-01-17 Last updated: 2014-03-27Bibliographically approved
    5. Fabrication of UV photo-detector based on coral reef like p-NiO/n-ZnO nanocomposite structures
    Open this publication in new window or tab >>Fabrication of UV photo-detector based on coral reef like p-NiO/n-ZnO nanocomposite structures
    Show others...
    2013 (English)In: Materials letters (General ed.), ISSN 0167-577X, E-ISSN 1873-4979, Vol. 108, 149-152 p.Article in journal (Refereed) Published
    Abstract [en]

    In this research work, a UV photo-detector is fabricated on fluorine doped tin oxide (FTO) glass substrate by exploiting the advantageous features of p-n heterojunctions based on p-NiO and n-ZnO composite nanostructures forming a coral-reef like structures. Scanning electron microscopy (SEM) and X-ray diffraction results showed uniform morphology and good crystal quality of the synthesised nanostructures respectively. I-V measurements have shown nonlinear and rectifying response of the p-NiO/n-ZnO heterojunction. The proposed photodiode exhibited excellent UV response with acceptable photocurrent generation of about 3.4 mA and the responsivity of 2.27 A/W at -3 biasing voltage.

    Place, publisher, year, edition, pages
    Elsevier, 2013
    Keyword
    p-NiO/n-ZnO composite nanostructures, Photodiode, UV-visible spectrophotometry
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-99403 (URN)10.1016/j.matlet.2013.06.083 (DOI)000324562900038 ()
    Available from: 2013-10-17 Created: 2013-10-17 Last updated: 2014-04-04
    6. The fabrication of white light-emitting diodes using the n-ZnO/NiO/p-GaN heterojunction with enhanced luminescence
    Open this publication in new window or tab >>The fabrication of white light-emitting diodes using the n-ZnO/NiO/p-GaN heterojunction with enhanced luminescence
    Show others...
    2013 (English)In: Nanoscale Research Letters, ISSN 1931-7573, E-ISSN 1556-276X, Vol. 8, no 320Article in journal (Refereed) Published
    Abstract [en]

    Cheap and efficient white light-emitting diodes (LEDs) are of great interest due to the energy crisis all over the world. Herein, we have developed heterojunction LEDs based on the well-aligned ZnO nanorods and nanotubes on the p-type GaN with the insertion of the NiO buffer layer that showed enhancement in the light emission. Scanning electron microscopy have well demonstrated the arrays of the ZnO nanorods and the proper etching into the nanotubes. X-ray diffraction study describes the wurtzite crystal structure array of ZnO nanorods with the involvement of GaN at the (002) peak. The cathodoluminescence spectra represent strong and broad visible emission peaks compared to the UV emission and a weak peak at 425 nm which is originated from GaN. Electroluminescence study has shown highly improved luminescence response for the LEDs fabricated with NiO buffer layer compared to that without NiO layer. Introducing a sandwich-thin layer of NiO between the n-type ZnO and the p-type GaN will possibly block the injection of electrons from the ZnO to the GaN. Moreover, the presence of NiO buffer layer might create the confinement effect.

    Keyword
    White light-emitting diode; ZnO nanorods; Nanotubes; NiO buffer layer
    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:liu:diva-103341 (URN)10.1186/1556-276X-8-320 (DOI)000331642900001 ()
    Available from: 2014-01-17 Created: 2014-01-17 Last updated: 2014-03-18Bibliographically approved
  • 90.
    Abbasi, Mazhar Ali
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Hussain Ibupoto, Zafar
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Hussain, Mushtaque
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    The fabrication of white light-emitting diodes using the n-ZnO/NiO/p-GaN heterojunction with enhanced luminescence2013In: Nanoscale Research Letters, ISSN 1931-7573, E-ISSN 1556-276X, Vol. 8, no 320Article in journal (Refereed)
    Abstract [en]

    Cheap and efficient white light-emitting diodes (LEDs) are of great interest due to the energy crisis all over the world. Herein, we have developed heterojunction LEDs based on the well-aligned ZnO nanorods and nanotubes on the p-type GaN with the insertion of the NiO buffer layer that showed enhancement in the light emission. Scanning electron microscopy have well demonstrated the arrays of the ZnO nanorods and the proper etching into the nanotubes. X-ray diffraction study describes the wurtzite crystal structure array of ZnO nanorods with the involvement of GaN at the (002) peak. The cathodoluminescence spectra represent strong and broad visible emission peaks compared to the UV emission and a weak peak at 425 nm which is originated from GaN. Electroluminescence study has shown highly improved luminescence response for the LEDs fabricated with NiO buffer layer compared to that without NiO layer. Introducing a sandwich-thin layer of NiO between the n-type ZnO and the p-type GaN will possibly block the injection of electrons from the ZnO to the GaN. Moreover, the presence of NiO buffer layer might create the confinement effect.

  • 91.
    Abbasi, Mazhar Ali
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Hussain Ibupoto, Zafar
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Hussain, Mushtaque
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Pozina, Galia
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Lu, Jun
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Hultman, Lars
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Decoration of ZnO nanorods with coral reefs like NiO nanostructures by the hydrothermal growth method and their luminescence study2014In: Materials, ISSN 1996-1944, Vol. 7, no 1, 430-440 p.Article in journal (Refereed)
    Abstract [en]

    Composite nanostructures of coral reefs like p-type NiO on n-type ZnO nanorods have been decorate on fluorine-doped tin oxide glass substrates by the hydrothermal growth. Structural characterization was performed by field emission scanning electron microscopy,  high-resolution transmission electron microscopy and X-ray diffraction techniques. This investigation has shown that the adopted synthesis has led to high crystalline quality nanostructures. Morphological study shows that the coral reefs like nanostructures are densely packed on the ZnO nanorods. Cathodoluminescence (CL) spectra for the synthesized composite nanostructures were dominated by a near band gap emission at 380 nm and by a broad interstitial defect related luminescence centered at ~630 nm. Spatially resolved CL images reveal that the luminescence originates mainly from the ZnO nanorods.

  • 92.
    Abbasi, Mazhar Ali
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Hussain Ibupoto, Zafar
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Khan, Azam
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Fabrication of UV photo-detector based on coral reef like p-NiO/n-ZnO nanocomposite structures2013In: Materials letters (General ed.), ISSN 0167-577X, E-ISSN 1873-4979, Vol. 108, 149-152 p.Article in journal (Refereed)
    Abstract [en]

    In this research work, a UV photo-detector is fabricated on fluorine doped tin oxide (FTO) glass substrate by exploiting the advantageous features of p-n heterojunctions based on p-NiO and n-ZnO composite nanostructures forming a coral-reef like structures. Scanning electron microscopy (SEM) and X-ray diffraction results showed uniform morphology and good crystal quality of the synthesised nanostructures respectively. I-V measurements have shown nonlinear and rectifying response of the p-NiO/n-ZnO heterojunction. The proposed photodiode exhibited excellent UV response with acceptable photocurrent generation of about 3.4 mA and the responsivity of 2.27 A/W at -3 biasing voltage.

  • 93.
    Abbasi, Mazhar Ali
    et al.
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Hussain Ibupoto, Zafar
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Khan, Yaqoob
    National Centre for Physics, Islamabad, Pakistan .
    Khan, Azam
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Iron (III) Ion Sensor Based on the Seedless Grown ZnO Nanorods in 3 Dimensions Using Nickel Foam Substrate2013In: Journal of Sensors, ISSN 1687-725X, E-ISSN 1687-7268, no 382726Article in journal (Refereed)
    Abstract [en]

    In the present work, the seedless, highly aligned and vertical ZnO nanorods in 3 dimensions (3D) were grown on the nickel foam substrate. The seedless grown ZnO nanorods were characterised by field emission scanning electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM), and X-ray diffraction (XRD) techniques. The characterised seedless ZnO nanorods in 3D on nickel foam were highly dense, perpendicular to substrate, grown along the (002) crystal plane, and also composed of single crystal. In addition to this, these seedless ZnO nanorods were functionalized with trans-dinitro-dibenzo-18-6 crown ether, a selective iron (III) ion ionophore, along with other components of membrane composition such as polyvinyl chloride (PVC), 2-nitopentylphenyl ether as plasticizer (NPPE), and tetrabutyl ammonium tetraphenylborate (TBATPB) as conductivity increaser. The sensor electrode has shown high linearity with a wide range of detection of iron (III) ion concentrations from 0.005 mM to 100 mM. The low limit of detection of the proposed ion selective electrode was found to be 0.001 mM. The proposed sensor also described high storage stability, selectivity, reproducibility, and repeatability and a quick response time of less than 10 s.

  • 94.
    Abbasi, Mazhar Ali
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Ibupoto, Zafar Hussain
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Hussain, Mushtaque
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Khan, Yaqoob
    Quaid-e-Azam University Campus, Islamabad, Pakistan.
    Khan, Azam
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Potentiometric Zinc Ion Sensor Based on Honeycomb-Like NiO Nanostructures2012In: Sensors, ISSN 1424-8220, Vol. 12, no 11, 15424-15437 p.Article in journal (Refereed)
    Abstract [en]

    In this study honeycomb-like NiO nanostructures were grown on nickel foam by a simple hydrothermal growth method. The NiO nanostructures were characterized by field emission electron microscopy (FESEM), high resolution transmission electron microscopy (HRTEM) and X-ray diffraction (XRD) techniques. The characterized NiO nanostructures were uniform, dense and polycrystalline in the crystal phase. In addition to this, the NiO nanostructures were used in the development of a zinc ion sensor electrode by functionalization with the highly selective zinc ion ionophore 12-crown-4. The developed zinc ion sensor electrode has shown a good linear potentiometric response for a wide range of zinc ion concentrations, ranging from 0.001 mM to 100 mM, with sensitivity of 36 mV/decade. The detection limit of the present zinc ion sensor was found to be 0.0005 mM and it also displays a fast response time of less than 10 s. The proposed zinc ion sensor electrode has also shown good reproducibility, repeatability, storage stability and selectivity. The zinc ion sensor based on the functionalized NiO nanostructures was also used as indicator electrode in potentiometric titrations and it has demonstrated an acceptable stoichiometric relationship for the determination of zinc ion in unknown samples. The NiO nanostructures-based zinc ion sensor has potential for analysing zinc ion in various industrial, clinical and other real samples.

  • 95.
    Abbasi, Mazhar Ali
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Khan, Yaqoob
    National Centre for Physics, Quaid-e-Azam University Campus, Islamabad, Pakistan .
    Hussain, Sajjad
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Nur, Omer
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Willander, Magnus
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Anions effect on the low temperature growth of ZnO nanostructures2012In: Vacuum, ISSN 0042-207X, E-ISSN 1879-2715, Vol. 86, no 12, 1998-2001 p.Article in journal (Refereed)
    Abstract [en]

    Seed mediated aqueous chemical growth (ACG) route was used for the growth of ZnO nanostructures on Si substrate in four different growth mediums. The growth medium has shown to affect the morphology and the size of the different nanostructures. We observed that the medium containing zinc nitrate anions yields the nanorods, in a medium containing zinc acetate anions nano-candles are obtained. While in a medium containing zinc chloride anions ZnO nano-discs were obtained and in a medium containing zinc sulfate anions nano-flakes are achieved. Growth in these different mediums has also shown effect on the optical emission characteristics of the different ZnO nanostructures.

  • 96.
    Abbasi, Muneeb Mehmood
    et al.
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Jabbar, Mohammad Abdul
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Design and Performance Analysis of Low-Noise Amplifier with Band-Pass Filter for 2.4-2.5 GHz2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Low power wireless electronics is becoming more popular due to durability, portability and small dimension. Especially, electronic devices in instruments, scientific and medical (ISM) band is convenient from the spectrum regulations and technology availability point of view. In the communication engineering society, to make a robust transceiver is always a matter of challenges for the better performance.

    However, in this thesis work, a new approach of design and performance analysis of Low-Noise Amplifier with Band-Pass filter is performed at 2.45 GHz under the communication electronics research group of Institute of Science and Technology (ITN). Band-Pass Filtered Low-Noise Amplifier is designed with lumped components and transmission lines. Performances of different designs are compared with respect to noise figure, gain, input and output reflection coefficient. In the design process, a single stage LNA is designed with amplifier, ATF-58143. Maximally flat band-pass (BPF) filters were designed with lumped components and distributed elements. Afterwards, BPF is integrated with the LNA at the front side of LNA to get a compact Band-Pass Filtered Low-Noise Amplifier with good performance.

    Advanced Design System (ADS) tool was used for design and simulation, and each design was tuned to get the optimum value for noise figure, gain and input reflection coefficient. LNA stand-alone gives acceptable value of noise figure and gain but the bandwidth was too wide compared to specification. Band-Pass Filtered Low-Noise Amplifier with lumped components gives also considerable values of noise and gain. But the gain was not so flat and the bandwidth was also wide. Then, Band-Pass Filtered Low-Noise Amplifier was designed with transmission lines where the optimum value of noise figure and gain was found. The gain was almost flat over the whole band, i.e., 2.4-2.5 GHz compared to LNA stand-alone and Band-Pass Filtered Low-Noise Amplifier designed with lumped components. It is observed that deviations of results from schematic to layout level are considerable, i.e., electromagnetic simulation is needed to predict the Band-Pass Filtered Low-Noise Amplifier performance.

    Prototype of LNA, Band-Pass Filtered Low-Noise Amplifier with lumped and transmission lines are made at ITN’s PCB laboratory. Due to unavailability of exact values of Murata components and for some other technical reasons, the measured values of Band-Pass Filtered Low-Noise Amplifier with lumped components and transmission lines are deviated compared to predicted values from simulation.

  • 97.
    Abbasi, Rizwan
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    A Framework For Interacting With Parameterized and Infinite State Verification Tools2013Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    We develop a tool to explore the behavior of parameterized systems (i.e., systems consisting of an arbitrary number of identical processes that synchronize using shared variables or global communications) and to ease user interaction with tools that verify them. The tool includes a user friendly GUI that allows the user to describe a parameterized system and to perform guided, interactive or random simulation. This tool empowers the user to plug in several independent verifiers to perform verification. A mockup verifier is developed in order to facilitate the development of the tool and testing the required functionalities. The mockup verifier involves parsing descriptions of the parameterized systems to be analyzed. In order to interact with the verifier, the tool is user friendly and flexible in the sense that the user can plug in a verifier developed in any language as long as it allows to perform a number of basic computations on the parameterized system (such as the set of enabled transitions or the set of successor configurations). In order to plug in a new tool, our tool needs to be able to make use of these operations, for instance using a wrapper written for a verifier particular to a class of parameterized systems. Given these operations, our tool enables the user to carry out various types of simulations like random, interactive or guided simulations. Moreover, our tool can submit verification queries to the underlying verifier and walk the user through the generated counter examples as if it was a simulation session.

  • 98.
    Abbasi, Saad Zeb
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    Automatic Test Builder2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In Ericsson, the Automation Team automates test cases that are frequently rerun. This process involves copying data related to a particular Configured Test Case from a database and then pasting it into a java file created to run a test case. In one java file, there can be more than one Configured Test Cases. So information can vary. Then the tester has to add package name, necessary imports, member variables, preamble and post amble methods, help methods and main execution methods. A lot of time and effort are consumed in writing the whole code. The Automation Team came up with a proposal of having a tool that can generate this whole information and the tester just has to add or remove minor changes. This will save time and resources. So the development of tool started and finally a tool named Automatic Test Builder developed in java was created to help automation teams in Ottawa, Kista and Linkoping.

    This document elaborates problem statement, opted approach, tools used in development process, a detailed overview of all development stages of Automatic Test Builder. This document also explains issues what came during the development, evaluation and usability analysis of Automatic Test Builder.

  • 99.
    Abbass, Allan
    et al.
    Dalhousie University, Canada.
    Bernier, Denise
    Dalhousie University, Canada.
    Kisely, Steve
    University of Queensland, Australia.
    Town, Joel
    Dalhousie University, Canada.
    Johansson, Robert
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences. Dalhousie University, Canada.
    Sustained reduction in health care costs after adjunctive treatment of graded intensive short-term dynamic psychotherapy in patients with psychotic disorders2015In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 228, no 3, 538-543 p.Article in journal (Refereed)
    Abstract [en]

    The aim of this pilot study was to evaluate the changes in symptom severity and long-term health care cost after intensive short-term dynamic psychotherapy (ISTDP) individually tailored and administered to patients with psychotic disorders undergoing standard psychiatric care. Eleven therapists with different levels of expertise delivered an average of 13 one-hour sessions of graded ISTDP to 38 patients with psychotic disorders. Costs for health care services were compiled for a one-year period prior to the start of ISTDP (baseline) along with four one-year periods after termination. Two validated self-report scales, the Brief Symptom Inventory and the Inventory of Interpersonal Problems, were administered at intake and termination of ISTDP. Results revealed that health care cost reductions were significant for the one-year post-treatment period relative to baseline year, for both physician costs and hospital costs, and the reductions were sustained for the follow-up period of four post-treatment years. Furthermore, at treatment termination self-reported symptoms and interpersonal problems were significantly reduced. These preliminary findings suggest that this brief adjunctive psychotherapy may be beneficial and reduce costs in selected patients with psychotic disorders, and that gains are sustained in long-term follow-up. Future research directions are discussed. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

  • 100.
    Abbass, Allan
    et al.
    Dalhousie University, Canada.
    Johansson, Robert
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Rasic, Daniel
    Dalhousie University, Canada.
    Town, Joel M.
    Dalhousie University, Canada.
    Johansson, Robert
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Long-term healthcare cost reduction with Intensive Short-term Dynamic Psychotherapy in a tertiary psychiatric service2015In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 64, 114-120 p.Article in journal (Refereed)
    Abstract [en]

    Objective: To evaluate whether a mixed population of patients treated with Intensive Short-term Dynamic Psychotherapy (ISTDP) would exhibit reduced healthcare costs in long-term follow-up. Methods: A quasi-experimental design was employed in which data on pre- and post-treatment healthcare cost were compared for all ISTDP cases treated in a tertiary care service over a nine year period. Observed cost changes were compared with those of a control group of patients referred but never treated. Physician and hospital costs were compared to treatment cost estimates and normal population cost figures. Results: 1082 patients were included; 890 treated cases for a broad range of somatic and psychiatric disorders and 192 controls. The treatment averaged 7.3 sessions and measures of symptoms and interpersonal problems significantly improved. The average cost reduction per treated case was $12,628 over 3 follow-up years: this compared favorably with the estimated treatment cost of $708 per patient. Significant differences were seen between groups for follow-up hospital costs. Conclusions: ISTDP in this setting appears to facilitate reductions in healthcare costs, supporting the notion that brief dynamic psychotherapy provided in a tertiary setting can be beneficial to health care systems overall. (C) 2015 Elsevier Ltd. All rights reserved.

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