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  • 51.
    Landtblom, Anne-Marie
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology.
    Dige, N
    Schwerdt, K
    Säfström, Kåge
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Granerus, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Short-term memory dysfunction in Kleine-Levin syndrome2003In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 108, no 5, p. 363-367Article in journal (Refereed)
    Abstract [en]

    Background - A previous investigation at our department of a young man with typical Kleine-Levin syndrome revealed short-term memory dysfunction as well as hypoperfusion of the temporal lobes on single photon emission tomography (SPECT) (CERETECR) examination, 6 and 7 years after recovery, suggesting long lasting or even permanent cerebral dysfunction. Patients and methods - We investigated four cases with classical adolescent Kleine-Levin syndrome characterized by hypersomnia and typical associated symptoms. We used neuropsychological testing and SPECT (CERETECR) of the brain. The results from the previous report related to above is included. Results - Examination with SPECT (CERETECR) during remission revealed hypoperfusion of the temporal lobes and fronto-temporal region in two of four cases. There were normal findings in two. Neuropsychological testing performed during remission showed reduction in the short-term memory capacity in all four cases. Conclusion - It is striking that all the cases investigated showed short-term memory dysfunction. One patient who had recovered from paroxysmal symptoms (hypersomnia attacks and bulimia) 6 years earlier showed progress in the short-term memory dysfunction. A pathologic condition in the temporal lobes may be suspected in Kleine-Levin syndrome.

  • 52.
    Landtblom, Anne-Marie
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Fridriksson, Steen
    Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Boivie, Jörgen
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Hillman, Jan
    Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Johansson, G.
    Linköping University, Department of Neuroscience and Locomotion, Neurology. Linköping University, Faculty of Health Sciences.
    Johansson, Ingegerd
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
    Sudden onset headache: a prospective study of features, incidence and causes2002In: Cephalalgia, ISSN 0333-1024, E-ISSN 1468-2982, Vol. 22, no 5, p. 354-360Article in journal (Refereed)
    Abstract [en]

    Sudden onset headache is a common condition that sometimes indicates a life- threatening subarachnoid haemorrhage (SAH) but is mostly harmless. We have performed a prospective study of 137 consecutive patients with this kind of headache (thunderclap headache = TCH). The examination included a CT scan, CSF examination and follow-up of patients with no SAH during the period between 2 days and 12 months after the headache attack. The incidence was 43 per 100 000 inhabitants > 18 years of age per year; 11.3% of the patients with TCH had SAH. Findings in other patients indicated cerebral infarction (five), intracerebral haematoma (three), aseptic meningitis (four), cerebral oedema (one) and sinus thrombosis (one). Thus no specific finding indicating the underlying cause of the TCH attack was found in the majority of the patients. A slightly increased prevalence of migraine was found in the non-SAH patients (28%). The attacks occurred in 11 cases (8%) during sexual activity and two of these had an SAH. Nausea, neck stiffness, occipital location and impaired consciousness were significantly more frequent with SAH but did not occur in all cases. Location in the temporal region and pressing headache quality were the only features that were more common in non-SAH patients. Recurrent attacks of TCH occurred in 24% of the non-SAH patients. No SAH occurred later in this group, nor in any of the other patients. It was concluded that attacks caused by a SAH cannot be distinguished from non-SAH attacks on clinical grounds. It is important that patients with their first TCH attack are investigated with CT and CSF examination to exclude SAH, meningitis or cerebral infarction. The results from this and previous studies indicate that it is not necessary to perform angiography in patients with a TCH attack, provided that no symptoms or signs indicate a possible brain lesion and a CT scan and CSF examination have not indicated SAH.

  • 53.
    Larsson, C
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, Anestesi.
    Davidsson, L
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Lundin, P
    Gustafsson, G
    Vegfors, M
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Anaesthesiology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, Anestesi.
    Respiratory monitoring during MR imaging. the clinical value of a new fibre-optical monitor.1999In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 40, p. 33-36Article in journal (Refereed)
  • 54.
    Lindahl, Tomas
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
    Lundahl, T
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Clinical Chemistry.
    Fransson, Sven Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Evaluation of an automated micro-latex D-dimer assay (Tina-quant on Hitachi 911 analyser) in symptomatic outpatients with suspected vein thrombosis.1999In: Thrombosis and Haemostasis, ISSN 0340-6245, Vol. 82, p. 1772-1773Article in journal (Refereed)
  • 55.
    Lindgren, Stefan
    et al.
    Malmö.
    Egidius, Henry
    Lund.
    Måre, Klas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Petersson, Göran
    Härnösand.
    Hammar, Mats
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Fortbildning skall utgå från den kliniska verkligheten. Det krävs mod att se både de starka och de svaga sidorna i yrkessituationen.2001In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 25, p. 3002-3006Article in journal (Other academic)
  • 56. Lundström, Åsa
    et al.
    Jendel, Johan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Internal Medicine. Östergötlands Läns Landsting, MKC-2, GE: endomed.
    Stenström, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Toss, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Internal Medicine. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
    Ravald, Nils
    Periodontal conditions in 70-year-old women with osteoporosis.2001In: Swedish Dental Journal, ISSN 0347-9994, Vol. 25, p. 89-96Article in journal (Refereed)
  • 57.
    Mathiesen, UL
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology.
    Franzén, LE
    Åselius, H
    Resjö, M
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Jacobsson, L
    Foberg, U
    Frydén, Aril
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Infectious Diseases. Östergötlands Läns Landsting, Centre for Medicine, Department of Infectious Diseases in Östergötland.
    Bodemar, Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Östergötlands Läns Landsting, MKC - Medicin och kirurgicentrum, EMK-magtarm.
    Increased liver echogenicity at ultrasound examination reflects degree of steatosis but not of fibrosis in asymptomatic patients with mild/moderate abnormalities of liver transaminases2002In: Digestive and Liver Disease, ISSN 1590-8658, E-ISSN 1878-3562, Vol. 34, no 7, p. 516-522Article in journal (Refereed)
    Abstract [en]

    Aims. To investigate whether hyperechogenicity of liver can reliably be interpreted as liver steatosis and if any concomitant or isolated fibrosis can be disclosed. Patients and methods. A series of 165 patients with no signs or symptoms of liver disease referred because of slightly to moderately raised aminotransferases (alanine aminotransferase and/or aspartate aminotransferase 0.7-5.0 ╡kat/l) for more than 6 months were prospectively investigated with a comprehensive laboratory profile, ultrasound examination of liver and percutaneous liver biopsy. Fibrosis was assessed quantitatively and according to Metavir. Steatosis was graded as none, mild, moderate or severe. Results. Of 98 (59.4%) patients with raised echogenicity, 85 (86.7%) had liver steatosis of at least moderate degree, 9 patients with same degree of steatosis had normal echogenicity and 13 patients with no or only mild steatosis had normal echogenicity liver (sensitivity 0.90, specificity 0.82, positive predictive value 0.87, negative predictive value 0.87). About the same relations were found regardless of body mass index and degree of fibrosis. With increased echogenicity together with high attenuation (n=59) and reduced portal vessel wall distinction (n=79), positive predictive value increased to 0.93 and 0.94, respectively. Quantitatively assessed fibrosis (mean ▒ SD) was 3.2▒4.6% of biopsy area with normal and 2.3▒1.8% with raised echogenicity [ns]. Echogenicity was normal in 5 out of 9 patients with septal fibrosis and in 4 out of 6 patients with cirrhosis. Any structural, non-homogenous findings at ultrasound were not associated with architectural fibrotic changes and none had nodular contours of liver surface. Conclusions. Assessment of liver echogenicity is of value for detection or exclusion of moderate to pronounced fatty infiltration (correct classification 86.6%) but cannot be relied upon in diagnosing fibrosis, not even cirrhosis in asymptomatic patients with mild to moderately elevated liver transaminases.

  • 58.
    Måre, Klas
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Petré, Bengt
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Lundberg, Nina
    Quality assurance system feedback2001In: Röntgenveckan i Umeå 20-24 augusti 2001,2001, 2001, p. 29-30Conference paper (Refereed)
  • 59.
    Nilsson, Sven
    et al.
    Uppsala.
    Bergstrand, Lott
    Stockholm.
    Erikson, Uno
    Uppsala.
    Johansson, Jan
    Stockholm.
    Smedby, Örjan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Walldius, Göran
    Astra-Zeneca .
    Allergic reactions at repeat femoral angiography with ioxaglate.2001In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 42, p. 608-611Article in journal (Refereed)
  • 60. Nilsson, Sven
    et al.
    Bergstrand, Lott
    Erikson, Uno
    Johansson, Jan
    Smedby, Örjan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Walldius, Göran
    Allergic reactions at repeat femoral angiography with ioxaglate2000In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 42, p. 608-611Article in journal (Refereed)
  • 61. Nilsson, Sven
    et al.
    Eriksson, Barbro
    Smedby, Örjan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Kvantifiering av levermetastaser med datortomografisk arbetsstation2001In: Medicinska Riksstämman i Stockholm/Älvsjö,2001, 2001, p. 253-253Conference paper (Refereed)
  • 62. Nilsson, Tage
    et al.
    Måre, Klas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Carlsson, A
    Value of structured clinical and scintigraphic protocols in acute pulmonary embolism2001In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 250, no 3, p. 213-218Article in journal (Refereed)
    Abstract [en]

    Purpose. To study the use of a combination of a clinical and scintigraphic protocol in relation to the final outcome diagnosis in patients with clinical suspicion of acute pulmonary embolism (PE). Material and methods. A total of 170 patients with clinical suspicion of acute PE were all examined with ECG, blood chemistry, chest X-ray, pulmonary scintigraphy and selective pulmonary arteriography. The scintigraphic and clinical probabilities of PE were estimated on visual analogue scales (VASs) by different readers unaware of each others' results. The follow-up time was 6 months. In order to establish the final diagnosis a final outcome committee was created. They analysed in retrospect all the clinical and laboratory data and established whether the patient had had PE or not. Results. The final outcome committee concluded that 53 patients had PE. When the scintigraphic and clinical probability judgements were congruent, a combined probability of 1-25% (i.e low probability) had a negative predictive value of 98%. When the combined probability was 26-75% (i.e. intermediate) half of the cases had PE. With a combined probability of 76-100% (i.e. high) the positive predictive value was 100%. Conclusion. By applying a model of combined clinical and scintigraphic probabilities for PE, the diagnosis is ruled in when the combined probability is high, and ruled out when the combined probability is low. However, nearly half of the patients will still have an uncertain diagnosis for which further diagnostic procedures may be allocated.

  • 63.
    Norén, Bengt
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Book Review: Atlas of cross-sectional and projective MR cholangiopancreatography; L van Hoe, D Vanbeckevoort and W Van Seenbergen.2000In: European Journal of Surgery, ISSN 1102-4151, E-ISSN 1741-9271, Vol. 166, p. 349-349Article in journal (Other (popular science, discussion, etc.))
  • 64.
    Norén, Bengt
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    MECP möjligheter, begränsningar, utveckling2002In: Läkarmöte "ERCP-Nyheter inom gallvägsdiagnostik och handläggning", Norrköping 24 sept 2002,2002, 2002Conference paper (Refereed)
  • 65.
    Norén, Bengt
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Morales, Olallo
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Smedby, Örjan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Renhet och kontrastbeslag - jämförelse mellan två tarmrengöringsmetoder vid colonröntgen2001In: Medicinska Riksstämman i Stockholm/Älvsjö,2001, 2001, p. 254-254Conference paper (Refereed)
  • 66.
    Norén, Bengt
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Smedby, Örjan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Ressner, Marcus
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Lundberg, Peter
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radio Physics. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Quantification of liver metabolites with phosphorus-31 Magnetic Resonance Spectroscopy2002In: European Congress of Radiology March 1-5, 2002,2002, 2002, p. 353-353Conference paper (Refereed)
  • 67. Nyström, Ingela
    et al.
    Smedby, Örjan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    A New presentation method for magnetic resonance angiography images based on skeletonization2000In: Proceedings of SPIE jfr 1998-2000 SPIE proceedings ISSN 1017-2653, ISSN 1605-7422, Vol. 3976, p. 515-522Article in journal (Refereed)
  • 68. Nyström, Ingela
    et al.
    Smedby, Örjan
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Analysis of magnetic resonance angiography images using skeletonization and distance tranforms.2000In: Discrete mathematics and theoretical computer science (Online), ISSN 1462-7264, E-ISSN 1365-8050, Vol. 55, p. 75-89Article in journal (Refereed)
  • 69.
    Nyström, Ingela
    et al.
    Uppsala University, Sweden.
    Smedby, Örjan
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Analysis of magnetic resonance angiography images using skeletonization and distance transforms2000In: Discrete Mathematical Problems with Medical Applications / [ed] Ding-Zhu Du, Panos M. Pardalos and Jie Wang, American Mathematical Society (AMS), 2000, p. 75-89Conference paper (Refereed)
    Abstract [en]

    Magnetic resonance angiography (MRA) is increasingly performed as a non-invasive method of evaluating patients with suspected vascular disease. In this study we have used images of the arteries of the pelvis obtained after intravenous injection of paramagnetic contrast material, i.e., gadolinium chelates, for arterial enhancement. These images are fairly easy to segment. When interpreting and analysing MRA images, the 3D tree structure and the thickness of the blood vessels are of interest. This shape information may be easier to obtain from the "skeleton" of the blood vessels.

    The following image processing steps were performed in the analysis of the blood vessels: resampling the image to cubic voxels, segmentation of the blood vessels from the background through grey-level thresholding and morphological smoothing operations, distance transformation, skeletonization, skeleton pruning (and straightening of zig-zag parts), and finally quantitative (and qualitative) skeleton analysis.

    Skeletonization of digital volume objects is either a reduction to a 2D structure consisting of 3D surfaces and curves, or a reduction to a 1D structure consisting of 3D curves only. Thin elongated objects, e.g., blood vessels, are well suited for reduction to curve skeletons. Our skeletonization method first reduces the object to a surface skeleton from which the original object can be recovered. Secondly, the surface skeleton is reduced to a curve skeleton. The topology (i.e., number of components, tunnels, and cavities) and the shape of the object are preserved. The skeletonization is based on a small number of simple local neighbourhood operations, which makes it fairly time efficient. The skeletal voxels are labelled with their (D6) distance to the original background, which in this case conveys information about the local width of the object. Positions for possible artery stenoses may be identified by locating local distance minima in our curve skeletons, which will be investigated further.

    Future work will also be directed towards achieving more rotation and noise independent skeletons. We will also develop more "intelligent" and shape preserving pruning methods.

  • 70.
    Nyström, Ingela
    et al.
    Uppsala.
    Smedby, Örjan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Skeletonization of volumetric vascular images - distance information utilized for visualization2001In: Journal of combinatorial optimization, ISSN 1382-6905, E-ISSN 1573-2886, Vol. 5, p. 27-41Article in journal (Refereed)
  • 71.
    Nägga, Katarina
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Geriatrics. Linköping University, Faculty of Health Sciences.
    Rådberg, Claes
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
    Marcusson, Jan
    Linköping University, Department of Neuroscience and Locomotion, Geriatrics. Linköping University, Faculty of Health Sciences.
    CT brain findings in clinical dementia investigation: underestimation of mixed dementia2004In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 18, no 1, p. 59-66Article in journal (Refereed)
    Abstract [en]

    Dementia has been found to display a more heterogeneous clinical picture than previously recognized. We investigated brain changes on computed tomography (CT) in a clinical dementia population consisting of 67 cases with Alzheimer's disease (AD), 13 with mixed dementia (AD and vascular dementia, VaD), 71 with VaD, and 12 cases that were not demented. Temporal cortical atrophy and atrophy around the temporal horns were more common in patients with mixed dementia compared to patients with VaD and the non-demented, respectively. Frontal white matter changes were present in 64% of AD, in 85% of mixed dementia and in 79% of VaD cases, but there were no differences between the dementia groups. Lacunes were present in almost 40% of AD cases and in 80 and 85% of VaD and mixed dementia cases, respectively. Only 14% of the VaD cases had large infarcts on the CT. We conclude that large infarcts were rare, even in VaD cases. The increased incidence of white matter changes and lacunes in AD patients strongly indicates an underestimation of the mixed dementia diagnosis. More distinct criteria for this diagnostic category are warranted.

  • 72.
    Olhager, Elisabeth
    et al.
    Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Department of health and environment. Linköping University, Faculty of Health Sciences.
    Thuomas, Karl-Åke
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
    Wigström, Lars
    Linköping University, Department of Medicine and Care, Clinical Physiology. Linköping University, Faculty of Health Sciences.
    Forsum, Elisabet
    Linköping University, Department of Biomedicine and Surgery, Nutrition. Linköping University, Faculty of Health Sciences.
    Description and evaluation of a method based on magnetic resonance imaging to estimate adipose tissue volume and total body fat in infants1998In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 44, no 4, p. 572-577Article in journal (Refereed)
    Abstract [en]

    Information about body fatness is important during nutritional assessment of infants, but current methods to estimate body composition in vivo are often not applicable in infants. Therefore, a new method based on magnetic resonance imaging (MRI) was developed. This method, which can assess the volume and distribution of adipose tissue (AT) as well as total body fat, was applied in 11 healthy full-term infants. Their total body water was also estimated using the isotope dilution technique. Adipose tissue volume (ATV) was calculated from AT area in 16 images of the body taken by an MRI scanner (1.5 tesla). AT area was assessed using a computer program in which AT criteria was defined by the observer. ATV of the infants was therefore evaluated once by three observers and twice by a fourth observer. The different observers estimated total, s.c., and non-s.c. ATV with a precision that varied between 1.9 and 7.2%, 2.0 and 4.8%, and 4.2 and 40.7%, respectively. Variations during AT area calculations accounted for a large part of the imprecision when assessing total and s.c. ATV. The linear relationship between percent total body water and total ATV in relation to body weight was significant in all evaluations. Although average total ATV varied when estimated by the four observers, there was, within each evaluation, a fairly constant order between infants with respect to their ATV. It is concluded that the MRI procedure represents a useful possibility to assess body fatness in infants.

  • 73.
    Ordell, Sven
    et al.
    Public Dental Service, Motala Sweden.
    Stenström, Birgitta
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Aspects of the quality of the information contained in radiological referrals2002In: Swedish Dental Journal, ISSN 0347-9994, Vol. 26, no 3, p. 135-140Article in journal (Refereed)
    Abstract [en]

    A referral letter is an important carrier of information, and it is important that it contains what both the recipient and the referrers expect. Based on the concept of perceived quality of service, 126 consecutive referrals from the General Dental Service (GDS) and their associated replies from the Department of Oral Radiology (OR) were mutually evaluated. OR judged that necessary information about the patient was specified in over 80% of the cases, and that information pertinent to the issue and the proposed examination was included in over 90% of the cases. The referrers were very satisfied with the replies they received. Only 1% reported that the information contained in the reply was not satisfactory for the continued care of the patient. Ninety-one per cent reported that they felt the reply to their referral was adequately long. A mutual questionnaire is a practicable tool to ensure quality in the referral process.

  • 74.
    Persliden, Jan
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radio Physics.
    Beckman, Karl-Wilhelm
    Geijer, Håkan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology.
    Andersson, Torbjörn
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology.
    Dose-image optimisation in digital radiology with a direct digital detector: an example applied to pelvic examination2002In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 12, p. 1584-1588Article in journal (Refereed)
  • 75.
    Persliden, Jan
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radio Physics. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics.
    Beckman, KW
    Örebro.
    Geijer, Håkan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology.
    Andersson, T
    Örebro.
    Optimisation of the relationship of the dose-image quality for a new direct digital detector.2001In: Eur Radiol,2001, 2001, p. 279-279Conference paper (Refereed)
  • 76.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    3D volume rendering helical CT cholangiography2002In: 3rd Int'l Workshop on Multislice CT 3D Imaging Virtual Endoscopy, Rom, juni 2002,2002, 2002Conference paper (Refereed)
  • 77.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    3D volume rendering helical CT cholangiography. A new method to visualise normal and obstructed bile ducts.2002In: The Museum of Medical History, Stockholm, maj 2002,2002, 2002Conference paper (Refereed)
  • 78.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    3D-Volume-Rendering Helical CT cholangiography (Rome, June6-8, 2002; Springer Verlag)2002In: Syllabus 3rd international workshop on:Multislice CT, 3D Imaging, virtual endoscopy, Linköping: Linköpings universitet , 2002, p. 107-109Chapter in book (Other academic)
  • 79.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    CT Colonography2002In: Regionmöte i Radiologi, Västervik, maj 2002,2002, 2002Conference paper (Refereed)
  • 80.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Diagnostike muligheter med ny teknologi2002In: PACS 2002 Nationell PACS/RIS-konferens, Trondheim, febr 2002,2002, 2002Conference paper (Refereed)
  • 81.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Digital technologies push x-ray images beyond today's boundaries2002In: Workshop Campus Norrköping, 3D Visualisation in Health Care, maj 2002,2002, 2002Conference paper (Refereed)
  • 82.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    From Polyp to Colorectal Cancer. Computed tomographic colonography2002In: 9th Postgraduate Novemer Symposium, Linköping nov 2002,2002, 2002Conference paper (Refereed)
  • 83.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Morgondagens diagnostiska arbetsuppgifter och bildhantering2002In: Röntgenveckan 2002, Örebro,2002, 2002Conference paper (Refereed)
  • 84.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Promising Preliminary Results for CT Scan of Coronary Vessels2002In: International Symposium Cardiac Imaging, Moskva, april 2002,2002, 2002, p. 64-69Conference paper (Refereed)
  • 85.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Rymden i bilden2002In: Odontologisk riksstämma, Göteborg 2002,2002, 2002, p. 42-42Conference paper (Refereed)
  • 86.
    Persson, Anders
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Virtuell koloskopi - ett hot mot skopisten?2002In: Mag-tarmklubbens temadat - Södra Stockholm mars 2002,2002, 2002Conference paper (Refereed)
  • 87.
    Persson, Anders
    Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Department of Medicine and Care, Radiology. Linköping University, Department of Molecular and Clinical Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences.
    Volume imaging of the abdomen: three-dimensional visualisation of tubular structures in the body with CT and MRI2005Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The overwhelming amount of image-based information in modem medicine makes it crucial to develop methods to handle and analyze images and make them comprehensible for users. The aim of this thesis was to study the radiological practice of three-dimensional (3D) visualization of tubular structures in the body with CT and MRI. All the studies cancern 3D imaging of tubular structures with camputed tomography (CT) and magnetic resonance imaging (MRI). The first three studies examine the abdominal aorta; the two later ones the, bile ducts.

    Study I compared measurements of aorta diameters taken from MR images presented using two visualization methods - maximum intensity projection (MlP) and volume rendering (VRT) - with invasive angiography (DSA) and CT as reference methods. Mean diameters of MR images were smaller than those from DSA and CT when MlP was used, but in general not when VRT was used.

    Study II evaluated the dependence on the observer and the choice of method and settings during rendering using the same material as in Study 1. In both MlP and VRT, the choice of settings had significant influence on the results. With DSA as the reference method, VRT gave larger measurement errors than MIP when the rendering parameters were set to fixed values, but not if the user was allowed to select the settings freely.

    Study III evaluated three new techniques for standardizing VRT protocols for MRA. Inter-reader variability and agreement with DSA were studied by comparing diameter measurements of the abdominal aorta obtained by the three new techniques, by VRT with freely chosen parameters and by MlP. All three new methods were significantly better than MlP and VRT with freely chosen parameters conceming inter-observer agreement. Agreement with DSA was significantly better for one of the methods. Standardized protocols seem to have a potential to make VRT a clinically useful alternative to MlP for MR angiography measurements.

    Study IV evaluated CT imaging of the bile ducts after drip intravenous infusion of the contrast medium iotroxate (CT cholangiography) in terms of adverse effects and visibility. With infusion time adjusted for individual variation in serum bilirubin concentration, a total side-effect frequency of less than 1% was found. A systematic review of previously published studies indicated a frequency of 2.3%. Good contrast excretion and visualization of bile ducts even in patients with elevated bilirubin levels were noted.

    Study V evaluated the diagnostic benefits of the same imaging method by comparing it with findings from surgery and endoscopic retrograde cholangiopancreatography (ERCP). The consensus sensitivity and specificity for diagnosing biliary stones was 88% and 94%, respectively. The use of VRT improved diagnostic certainty in 14% of the evaluatians, and the visualization of ductal stones was improved in 38% of the positive cases.

    In conclusion, volume rendering technique with standardized parameters may become a clinically useful tool in the clinical MRI environment. DIC-CT with bilirubin-governed infusion time and volume rendering post-processing produces detailed images of the biliary tree, resulting in good sensitivity and specificity. Moreover the safety is acceptable.

    List of papers
    1. Measurements before endovascular repair of abdominal aortic aneurysms: MR imaging with MRA vs. angiography and CT
    Open this publication in new window or tab >>Measurements before endovascular repair of abdominal aortic aneurysms: MR imaging with MRA vs. angiography and CT
    Show others...
    2003 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 44, no 2, p. 177-184Article in journal (Refereed) Published
    Abstract [en]

    Purpose: 1) To compare measurements obtained with MR imaging (MRI)/contrast-enhanced MR angiography (CE MRA) with measurements obtained with angiography (DSA) and CT, for stent-graft sizing of abdominal aortic aneurysms (AAA). 2) To compare MRA measurements obtained with the two post processing techniques MIP (maximum intensity projection) and VRT (3D volume rendering technique).

    Material and Methods: The prospective study included 20 consecutive patients with AAA identified by DSA and CT as suitable for endovascular repair. For the study, MRI/CE MRA was performed. Five measurement variables for stent-graft sizing were chosen. Comparisons were made between MRI/CE MRA, DSA and CT, and between observers. Comparisons were also made between MIP and VRT.

    Results: Significantly shorter lengths were obtained with MRA-MIP than with DSA. Three out of six diameter measurements were significantly smaller on MRI/CE MRA than on DSA and CT. No significant differences were found between the observers. One diameter measurement was significantly smaller on MIP than on VRT, while the other measurements showed no significant differences.

    Conclusion: The length measurements obtained with MRA-MIP were probably more correct than those with DSA. For more reliable diameter measurements with CE MRA, improvements of the technique, including VRT reconstructions and a standardized determination of the vessel boundaries, are needed.

    Keywords
    Abdominal aortic aneurysm, Angiography, CT, Endograft sizing, MR angiography, Volume rendering technique
    National Category
    Natural Sciences
    Identifiers
    urn:nbn:se:liu:diva-46720 (URN)10.1034/j.1600-0455.2003.00029.x (DOI)
    Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13Bibliographically approved
    2. Volume rendering compared with maximum intensity projection for magnetic resonance angiography measurements of the abdominal aorta
    Open this publication in new window or tab >>Volume rendering compared with maximum intensity projection for magnetic resonance angiography measurements of the abdominal aorta
    Show others...
    2004 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 45, no 4, p. 453-459Article in journal (Refereed) Published
    Abstract [en]

    Purpose: To compare the volume rendering technique (VRT) with maximum intensity projection (MIP) for aortic diameter measurements in MR angiography (MRA) data sets.

    Material and Methods: Existing contrast-enhanced 3-dimensional MRA and digital subtraction angiography (DSA) data sets from 20 patients were analyzed. In each MRA data set, two aortic diameters were measured using MIP and VRT. Agreement with DSA measurements, dependence on rendering parameters, and interobserver agreement were assessed.

    Results: Diameters measured on MIP with fixed parameters showed no significant difference compared with DSA and with freely selected parameters a slight overestimation relative to DSA. Diameters measured on VRT were larger than on DSA. For both MIP and VRT, the measurements depended on the chosen parameters. The error relative to DSA was larger for VRT than for MIP with fixed parameters but not with freely chosen parameters. Interobserver agreement did not differ significantly.

    Conclusions: VRT is not suitable for diameter measurements of the abdominal aorta with fixed parameter settings but may be useful with user-selected settings.

    Keywords
    Abdominal aortic aneurysm AAA, angiography, magentic resonance angiography MRA, maximum intensity projection MIP, under dependence, volume rendering technique VRT
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-24036 (URN)10.1080/02841850410006876 (DOI)3592 (Local ID)3592 (Archive number)3592 (OAI)
    Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13Bibliographically approved
    3. Standardized volume rendering for magnetic resonance angiography measurements in the abdominal aorta
    Open this publication in new window or tab >>Standardized volume rendering for magnetic resonance angiography measurements in the abdominal aorta
    Show others...
    2006 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, Vol. 47, no 2, p. 172-178Article in journal (Refereed) Published
    Abstract [en]

    Purpose: To compare three methods for standardizing volume rendering technique (VRT) protocols by studying aortic diameter measurements in magnetic resonance angiography (MRA) datasets.

    Material and Methods: Datasets from 20 patients previously examined with gadolinium-enhanced MRA and with digital subtraction angiography (DSA) for abdominal aortic aneurysm were retrospectively evaluated by three independent readers. The MRA datasets were viewed using VRT with three different standardized transfer functions: the percentile method (Pc-VRT), the maximum-likelihood method (ML-VRT), and the partial range histogram method (PRH-VRT). The aortic diameters obtained with these three methods were compared with freely chosen VRT parameters (F-VRT) and with maximum intensity projection (MIP) concerning inter-reader variability and agreement with the reference method DSA.

    Results: F-VRT parameters and PRH-VRT gave significantly higher diameter values than DSA, whereas Pc-VRT gave significantly lower values than DSA. The highest interobserver variability was found for F-VRT parameters and MIP, and the lowest for Pc-VRT and PRH-VRT. All standardized VRT methods were significantly superior to both MIP and F-VRT in this respect. The agreement with DSA was best for PRH-VRT, which was the only method with a mean error below 1 mm and which also had the narrowest limits of agreement (95% of cases between 2.1 mm below and 3.1 mm above DSA).

    Conclusion: All the standardized VRT methods compare favorably with MIP and VRT with freely selected parameters as regards interobserver variability. The partial range histogram method, although systematically overestimating vessel diameters, gives results closest to those of DSA.

    Keywords
    Abdominal aortic aneurysm (AAA); angiography; magnetic resonance angiography (MRA); maximum intensity projection (MIP); volume rendering technique (VRT); user dependence
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-14591 (URN)10.1080/02841850500445298 (DOI)000236669500010 ()
    Available from: 2007-08-24 Created: 2007-08-24 Last updated: 2017-12-13Bibliographically approved
    4. Three-dimensional drip infusion CT cholangiography in patients with suspected obstructive biliary disease: a retrospective analysis of feasibility and adverse reaction to contrast material
    Open this publication in new window or tab >>Three-dimensional drip infusion CT cholangiography in patients with suspected obstructive biliary disease: a retrospective analysis of feasibility and adverse reaction to contrast material
    2006 (English)In: BMC Medical Imaging, ISSN 1471-2342, E-ISSN 1471-2342, Vol. 6, no 1Article in journal (Refereed) Published
    Abstract [en]

    Background

    Computed Tomography Cholangiography (CTC) is a fast and widely available alternative technique to visualise hepatobiliary disease in patients with an inconclusive ultrasound when MRI cannot be performed. The method has previously been relatively unknown and sparsely used, due to concerns about adverse reactions and about image quality in patients with impaired hepatic function and thus reduced contrast excretion. In this retrospective study, the feasibility and the frequency of adverse reactions of CTC when using a drip infusion scheme based on bilirubin levels were evaluated.

    Methods

    The medical records of patients who had undergone upper abdominal spiral CT with subsequent three-dimensional rendering of the biliary tract by means of CTC during seven years were retrospectively reviewed regarding serum bilirubin concentration, adverse reaction and presence of visible contrast media in the bile ducts at CT examination. In total, 153 consecutive examinations in 142 patients were reviewed.

    Results

    Contrast media was observed in the bile ducts at 144 examinations. In 110 examinations, the infusion time had been recorded in the medical records. Among these, 42 examinations had an elevated bilirubin value (>19 umol/L). There were nine patients without contrast excretion; 3 of which had a normal bilirubin value and 6 had an elevated value (25–133 umol/L). Two of the 153 examinations were inconclusive. One subject (0.7%) experienced a minor adverse reaction – a pricking sensation in the face. No other adverse effects were noted.

    Conclusion

    We conclude that drip infusion CTC with an infusion rate of the biliary contrast agent iotroxate governed by the serum bilirubin value is a feasible and safe alternative to MRC in patients with and without impaired biliary excretion.

    In this retrospective study the feasibility and the frequency of adverse reactions when using a drip infusion scheme based on bilirubin levels has been evaluated.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-34913 (URN)10.1186/1471-2342-6-1 (DOI)24035 (Local ID)24035 (Archive number)24035 (OAI)
    Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13Bibliographically approved
    5. Volume rendering of three-dimensional drip infusion CT cholangiography in patients with suspected obstructive biliary disease: a retrospective study
    Open this publication in new window or tab >>Volume rendering of three-dimensional drip infusion CT cholangiography in patients with suspected obstructive biliary disease: a retrospective study
    2005 (English)In: British Journal of Radiology, ISSN 0007-1285, E-ISSN 1748-880X, Vol. 78, no 936, p. 1078-1085Article in journal (Refereed) Published
    Abstract [en]

    The purpose of this study was to evaluate the diagnostic potential of prolonged drip infusion CT cholangiography (DIC-CT) using meglumine iotroxate (Biliscopin®) and 3D volume rendering in patients with suspected obstructive biliary disease. From a material of 142 patients who had undergone a drip infusion CT, all cases with a verified surgical or endoscopic retrograde cholangiography (ERC) diagnosis (n=33) were selected. Age-matched controls were selected from the remaining examinations. Three radiologists reviewed all 66 examinations in retrospect, independently as well as in consensus. The image quality and the estimated diagnostic quality were rated as good or moderate in 91% of the 198 reviews. The consensus sensitivity and specificity for diagnosing biliary stones was 88% and 94%, respectively (with sensitivities ranging from 88% to 94% for individual observers, and specificities from 86% to 96%). Two out of three strictures were observed. No false positive strictures were described. The use of volume rendering technique (VRT) improved diagnostic certainty in 28/198 (14%) of the evaluations. The visualization of ductal stones was improved in 18/48 (38%). No differences in diagnostic quality between single and multislice CT were observed. We conclude that a detailed image of the biliary tree with good sensitivity and specificity can be obtained by means of bilirubin-governed infusion time DIC-CT with volume rendering reconstruction.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-30833 (URN)10.1259/bjr/14176682 (DOI)16483 (Local ID)16483 (Archive number)16483 (OAI)
    Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13Bibliographically approved
  • 88.
    Persson, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Borg, H
    Mitthögskolan.
    Moberg, A
    Hudiksvall.
    Brismar, T
    Stockholm.
    Imaging of skeletal structure inside a metal halpshere. A three-dimensional CT experimental study2002In: Kongress med Svensk Ortopedisk Förening, febr 2002, Norrköping,2002, 2002, p. 177-178Conference paper (Refereed)
  • 89.
    Persson, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Dahlström, N
    Hudiksvall.
    Engellau, L
    Lund.
    MRI och MRS data reconstruction and processing II2002In: ESMRMB 2002, Cannes,2002, 2002, p. 74-74Conference paper (Refereed)
  • 90.
    Persson, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Dahlström, N
    Hudiksvall.
    Engellau, L
    Lund.
    Larsson, E-M
    Lund.
    Brismar, T
    Stockholm.
    Volume rendering technique (VRT) compared with MIP for MRA of the abdominal aorta2002In: XIV Annual Int'l Workshop on MR-Angiography 2002, Essen,2002, 2002Conference paper (Refereed)
  • 91.
    Persson, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL. Linköping University, Center for Medical Image Science and Visualization, CMIV.
    Ranolf, M
    Palmberg, S
    Jern, M
    SMARTDOC: A System for real-time consultation and interacation of medical imaging data embeddes and integrated into dynamic pages accessible though internet explorer or MR word2002In: Radiology/RSNA, Chicago 2002,2002, 2002, p. 765-765Conference paper (Refereed)
  • 92.
    Petré, Bengt
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Petré, Bengt
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Petré, Bengt
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Petré, Bengt
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Måre, Klas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Lundberg, Nina
    Lundberg, Nina
    Kvalitetssäkring av röntgendiagnostik - Lätt som en plätt!2001In: Medicinska riksstämman i Stockholm/Älvsjö 2001,2001, 2001, p. 254-254Conference paper (Refereed)
  • 93.
    Påhlsson, H-I
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology.
    Wahlberg, E
    Olofsson, P
    Swedenborg, J
    The toe pole test for evaluation of arterial insuffiency in diabetic patients.1999In: European Journal of Vascular and Endovascular Surgery, ISSN 1078-5884, E-ISSN 1532-2165, Vol. 18, p. 133-137Article in journal (Refereed)
  • 94.
    Ragnehed, Mattias
    et al.
    Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
    Engström, Maria
    Linköping University, Department of Medicine and Care, Center for Medical Image Science and Visualization. Linköping University, Faculty of Health Sciences.
    Knutsson, Hans
    Linköping University, Department of Biomedical Engineering. Linköping University, Faculty of Health Sciences.
    Lundberg, Peter
    Linköping University, Department of Medicine and Care, Radiation Physics. Linköping University, Faculty of Health Sciences.
    Söderfeldt, Birgitta
    Linköping University, Department of Neuroscience and Locomotion. Linköping University, Faculty of Health Sciences.
    Performance of canonical correlation analysis in language tests by functional MRIManuscript (preprint) (Other academic)
    Abstract [en]

    In this paper a new method based on constraitwd canonical correlation analysis (CCA) for the analysis of fMRI data is evaluated. In particular the method benefits from a powerful way of choosing temporal basis functions in additiou to an adaptive spatial filtering scheme. A modified receiver operating characteristic (ROC) method was used to quantify the results and to compare it with traditionally used statistics in an objective way. The evaluation was performed using real fMRI data form a language test. It was shown that the CCA based method offers a significant gain in detection power.

  • 95.
    Ricther, Arina
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Cederholm, Ingemar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Thoracic Surgery. Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery.
    Jonasson, Lena
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Mucchiano, Carlo
    Smärtkliniken Eksjö.
    Janerot-Sjöberg, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Uchto, Michael
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Effect of thoracic epidural analgesia on refractory angina pectoris: Long-term home self-treatment2002In: Journal of Cardiothoracic and Vascular Anesthesia, ISSN 1053-0770, E-ISSN 1532-8422, Vol. 16, no 6, p. 679-684Article in journal (Refereed)
    Abstract [en]

    Objectives: To evaluate the effects of long-term home self-treatment with thoracic epidural analgesia (TEA) on angina, quality of life, and safety. Design: Prospective consecutive pilot study. Setting: Department of Cardiology, Heart Center, Link÷ping University Hospital. Participants: Between January 1998 and January 2000, 37 consecutive patients with refractory angina began treatment with TEA, using a subcutaneously tunnelled epidural catheter. Interventions: The patients were trained to provide self-treatment at home with intermittent injections of bupivacaine. Data were collected until January 2001, and the follow-up for each patient was 1 to 3 years. Measurements and Main Results: All but 1 of the patients improved symptomatically. The improvement was maintained throughout the treatment period (4 days to 3 years). The Canadian Cardiovascular Society angina class decreased from 3.6 to 1.7, frequency of anginal attacks decreased from 46 to 7 a week, nitroglycerin intake decreased from 32 to 5 a week, and the overall self-rated quality of life assessed by visual analog scale increased from 24 to 76 (all p < 0.001). No serious catheter-related complications occurred, however, 51% of the catheters became displaced and a new one had to be inserted during the study. Conclusion: Long-term self-administered home treatment with TEA seems to be an effective and safe adjuvant treatment for patients with refractory angina. It produces symptomatic relief of angina and improves the quality of life.

  • 96.
    Rinck, Peter A.
    et al.
    EMRF Foundation, World Trade Center, Sophia Antipolis Cedex, France.
    Ringertz, Hans
    Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medicine and Care, Radiology. Linköping University, Faculty of Health Sciences.
    Paul Christian Lauterbur2007In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 17, no 8, p. 2208-2210Article in journal (Other academic)
    Abstract [en]

    n/a

  • 97.
    Smedby, Örjan
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Rostad, H
    Klaastad, Örjan
    Lilleås, F
    Tillung, T
    Fosse, E
    Functional imaging of the thoracic outlet syndrome in an open MR scanner2000In: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 10, no 4, p. 597-600Article in journal (Refereed)
    Abstract [en]

    Symptoms due to thoracic outlet syndrome may present only in abduction, a position that cannot be investigated in conventional MR scanners. Therefore, this study was initiated to test MRI in an open magnet as a method for diagnosis of thoracic outlet syndrome. Ten volunteers and 7 patients with a clinical suspicion of thoracic outlet syndrome were investigated at 0.5 T in an open MR scanner. Sagittal 3D SPGR acquisitions were made in 0 and 90░abduction. In the patients, a similar data set was also obtained in maximal abduction. To assess compression, the minimum distance between the first rib and the clavicle, measured in a sagittal plane, was determined. In the neutral position, no significant difference was found between patients and controls. In 90░abduction, the patients had significantly smaller distance between rib and clavicle than the controls (14 vs 29 mm, p <0.01). On coronal reformatted images, the compression of the brachial plexus could often be visualised in abduction. Functional MR examination seems to be a useful diagnostic tool in thoracic outlet syndrome. Examination in abduction, which is feasible in an open scanner, is essential for the diagnosis.

  • 98.
    Strotman, JM
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Richter, Arina
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Kukuluski, T
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Voigt, J-U
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Fransson, Sven Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Wranne, Bengt
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Hatle, L
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Physiology. Östergötlands Läns Landsting, Heart Centre, Department of Clinical Physiology.
    Sutherland, GR
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Doppler Myocardial Imagning in the Assessment of Regional Myocardial Function in Longitudinal Direction Pre- and Post-PTCA.2001In: European Journal of Echocardiography, ISSN 1525-2167, E-ISSN 1532-2114, Vol. 2, p. 178-186Article in journal (Refereed)
  • 99.
    Svedjeholm, Rolf
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Thoracic Surgery. Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery.
    Olin, C
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Thoracic Surgery. Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery.
    Fransson, Sven Göran
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Granfeldt, H
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Thoracic Surgery. Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery.
    Successful salvage of the heart in left main occlusion with emergency retrograde perfusion2001In: 50th annual meeting scandinavian Association for thoracic surgery/21st meeting scandinavian society for extracorporal technology, Norge 2001,2001, 2001, p. 1008-1008Conference paper (Refereed)
  • 100. Tabar, L
    et al.
    Smith, RA
    Vitak, B
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Yen, M
    Chen, THH
    Warwick, J
    Myles, JP
    Duffy, SW
    Mammographic screening: A key factor in the control of breast cancer2003In: Cancer Journal, ISSN 0765-7846, E-ISSN 1292-8658, Vol. 9, no 1, p. 15-27Article in journal (Refereed)
    Abstract [en]

    [No abstract available]

123 51 - 100 of 118
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