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  • 651.
    Adolfsson, Lars
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Nestorson, Jens
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Scheer, Johan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences.
    Extensive soft tissue lesions in redislocated after simple elbow dislocations2017In: Journal of shoulder and elbow surgery, ISSN 1058-2746, E-ISSN 1532-6500, Vol. 26, no 7, p. 1294-1297Article in journal (Refereed)
    Abstract [en]

    Background: The majority of simple elbow dislocations (no associated fractures) can be treated nonoperatively with a short period of immobilization followed by guided aftercare. This case series describes the soft tissue injuries in a rare subset of patients in whom the elbow redislocated despite adequate immobilization. Methods: During a 6-year period, 8 patients were identified. They were all treated with reduction and casting in 90 degrees of flexion or more. At 1 week of follow-up, redislocation had occurred in all patients and open soft tissue repair was performed. The injuries were documented and the patients were followed up clinically and with radiographs. Results: Extensive soft tissue injuries, including both collateral ligament injuries and muscle origin avulsions from either or both sides, were found in all patients. The functional result at follow-up was satisfactory in all patients. Conclusion: Vast soft tissue injuries including both collateral ligaments and muscle origins should be expected in the event of early severe instability of a dislocated elbow joint. (C) 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.

  • 652.
    Adolfsson, Lars
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    Povlsen, B
    Arthroscopic findings in wrists with severe post-traumatic pain despite normal standard radiographs2004In: Journal of Hand Surgery - British and European Volume, ISSN 0266-7681, E-ISSN 1532-2211, Vol. 29 B, no 3, p. 208-213Article in journal (Refereed)
    Abstract [en]

    This study assessed the role of diagnostic arthroscopy following a wrist injury in patients with normal standard radiographs, an unclear clinical diagnosis and persistent severe pain at 4 to 12 weeks. Forty-three patients were included after conservative management had failed to improve their wrist pain so that a stability test could be performed satisfactorily and underwent arthroscopy within 12 weeks. Arthroscopy revealed recent pathology in 41 wrists, of which 17 had significant ligament lesions that might have benefited from acute repair. We conclude that patients with marked persistent post-traumatic symptoms despite conservative management are likely to have sustained ligament injuries despite normal radiographs. We therefore recommend that under these circumstances an arthroscopy is carried out within 4 weeks if the patient and surgeon wish to acutely repair significant ligament injuries.

  • 653. Adolfsson, L.E.
    et al.
    Nettelblad, Hans
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Surgery . Östergötlands Läns Landsting, Reconstruction Centre, Department of Plastic Surgery, Hand surgery UHL.
    Radial nerve entrapment in the upper arm as a cause of lateral arm pain: A report of four cases2001In: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, ISSN 2000-656X, E-ISSN 2000-6764, Vol. 35, no 2, p. 217-220Article in journal (Refereed)
    Abstract [en]

    Four patients with no history of trauma presented with lateral arm pain, local tenderness, and a tingling sensation at the distal end of the arm when the radial nerve was percussed in the mid-third of the upper arm (Tinel's sign), but no clinical or subjective signs of muscular weakness. They were treated by decompression of the radial nerve in the fibrous canal proximal to the lateral intermuscular septum. Three of the patients had a complete or pronounced reduction in pain, while the fourth had only a slight improvement. Non-traumatic radial nerve entrapment in the upper arm may be the cause of lateral arm pain without clinical signs of muscular weakness.

  • 654.
    Adolfsson, Lennart
    Linköping University, Department of Educational Science (IUV).
    Föräldrasamverkan i skolan. Ur ett elevperspektiv2004Independent thesis Basic level (professional degree)Student thesis
    Abstract [sv]

    Sedan folkskolan införande (och troligtvis ännu tidigare) har föräldrar haft synpunkter på deras barns undervisning i skolan. Politiker och andra styrande inom skolan har också förstått vitsen med föräldraengagemang i de egna barnens lärande som en tillgång för skolan. Sällan eller aldrig har eleverna frågats vad de tycker om föräldraengagemang i slan. I samarbete med en lokal skolstyrelse med föräldramajoritet är detta arbete gjort under vårterminen 2003. Syftet med arbetet är att ta reda på vad eleverna tycker om föräldrarnas engagemang i skolan och i klassrummet. Usökningen är avgränsad till att enbart gälla denna enda skola. Som undersökningsmetod har jag använt mig av en kvantitativ enkätundersökning utdelad till ca 250 elever. Av dessa har 91 % svarat, vilket får anses vara en mycket god svarsfrekvens.

    Vad tycker eleverna om att föräldrarna besöker skolan både som åhörare/hjälplärare, deltagare i utvecklingssamtal och delaktig i skolbeslut? De allra flesta elever har en positiv syn på föräldrars skolengagemang, även om det kan vara psamt ibland. Jag konstaterar att elever i stort uppskattar kontakter mellan föräldrar och skolans personal. Bland de mesteniga svaren var elevers absoluta tillit till att föräldrar har en dialog med klasslärare/lärare och att det är helt OK för föräldrar att prata med andra föräldrar.

    Elevers åsikter om föräldrar som bestämmer i skolan är lite tudelad men de flesta tycker att det är bra. Åsikten om evens medbestämmande i skolan varierar över årskurserna, där de lägre kurserna anser sig ha mer att säga till om än de högre. Något som samtliga årskurser var överens om var att utvecklingssamtal var en bra informationskanal. Några nior nämner utvecklingssamtalet som den enda kanalen "att få veta hur det går".

  • 655.
    Adolfsson, Lovisa
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Nilsson, Rebecca
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Collection structure design of deposited PET bottles and aluminium cans in northern Sweden2016Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    Returpack är ansvariga för Sveriges retursystem av tomma PET-flaskor och aluminiumburkar där insamling och hantering av förpackningar är en stor del av verksamheten. Transport av tomma förpackningar från butik till Returpacks fabrik i Norrköping sker huvudsakligen i form av lösvikt (bulklast) av Returpack. Övriga transporter av förpackningar sker i kartong eller säck där dryckesleverantörer sköter insamlingen. Syftet med denna studie är att skapa och undersöka olika typer av inhämtningsstrukturer för tomma förpackningar, där Returpack strävar efter att på ett kostnadseffektivt och miljömässigt sätt sköta inhämtningen samt öka kontrollen över flödet. I studien kommer fem områden i norra Sverige att undersökas, vilka skiljer sig från övriga områden i Sverige då dessa kännetecknas av långa avstånd mellan butiker samt låga volymer av förpackningar. I studien utförs ruttplanering av lösviktsinsamling samt totalkostnadberäkningar för varje område, där ett antal scenarier skapats med olika typer av inhämtningsstrukturer. I scenarierna varieras antalet butiker, mellanlager, ruttider samt insamlingsbilar. Utöver detta undersöks även fyra olika hubblösningar där förpackningarna gör en övergång från kartong- och säckflödet till lösviktsflödet. Resultaten av ruttplanerningarna visar att två av områdena har en hög belastning där antalet insamlingsbilar behöver ökas. Totalkostnadsberäkningarna tyder på att det går att sänka totalkostnaden i två av områdena genom att öka lösviktsinsamlingen. I de övriga tre områdena ger den nuvarande strukturen den lägsta totalkostnaden. Resultaten visar också att antalet fordonskilometer kan minska genom att addera ytterligare ett mellanlager i två av områdena. I studien visas det också att hubbar kan sänka kostnader för Returpack och minska antalet inkommande kartonger och säckar till fabriken. Att införa hubbar minskar också antalet fordonskilometer med mer än 50 %.

  • 656.
    Adolfsson, Maria
    et al.
    Linköping University, Department of Management and Economics.
    Solarz, Diana
    Linköping University, Department of Management and Economics.
    Power Shift and Retailer Value in the Swedish FMCG Industry2005Independent thesis Advanced level (degree of Magister)Student thesis
    Abstract [en]

    Background: The recent years in the Swedish Fast Moving Consumer Goods industry have been characterized by a palpable shift in power balance, favouring the retailers. Since the shift in power balance has strengthened the negotiation position of the retailers, the suppliers now have to, to a greater extent than before, accommodate to the retailers’ goals, whether they be financial or strategic.

    Purpose: The aim of this study was to investigate how this recent power shift has affected the relationships of suppliers and retailers. This development has resulted in the rather new and unexplored area of retailer value, which this study further aimed to explore.

    Research method: Interviews were conducted with representatives fromthe leading retailer chains and market leading suppliers.

    Results: The increased use of information and control on behalf of the retailers has led to the suppliers, to a greater extent than before, having to adjust to the retailers'different store concepts. However, in order to create retailer value, the suppliers also need to focus on the consumers’ needs and preferences, since the way to the retailer’s shelves is through creating consumer demand. They also have to stay innovative and make use of the experience and in-depth knowledge they possess within their product segments, as that is where they still have the upper hand.

  • 657.
    Adolfsson, Per
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Regulatory importance of cyclic nucleotides in smooth muscle growth of the urogenital tract2001Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Smooth muscle hyperplasia/hypertrophy is, if not responsible for, so at least involved in those diseases, which impair life quality for most people in today's society.

    This thesis, presents a pharmacological investigation, related to the regulatory role of cyclic nucleotides, of smooth muscle hyperplasia/hypeitrophy in human uterine leiomyoma and benign prostate hyperplasia (BPH).

    Four main aspects, with cAMP as a connecting thought, have been analyzed, namely expression and characterization of the adrenergic receptors (AR), determination of adenylyl cyclase (AC)- and phosphodiesterase (PDE)-activity, and finally the connection between mentioned issues and proliferation of cultured smooth muscle cells (smc).

    In the frrst paper, characterization of the a 2-adrenergic receptor (az-AR) subtypes in human myometrium at term pregnancy was examined by combining radioligand binding-studies with reverse transcriptase-polymerase chain reaction (RT-PCR). Results demonstrated a significant eo-expression of α2A and α2B, and a weak indication of the α2C-AR, which however was identified at the mRNA level by the RT-PCR analysis.

    In the next investigatio~ smooth muscle tissue of human uterine leiomyoma (benign smooth muscle tumor) was compared with surrounding myometrial tissue (control). The expression of AR, AC- and PDE-activity was analyzed, as well as the effect of cAMP with respect to growth regulation of cultured leiomyoma smc. Primarily, a significantly reduced ß2-AR expression and AC-activity was detected in leiomyoma compared to control tissue, whereas the PDE-activity was approximately 100% higher. In addition, the α2-AR population in leiomyoma was slightly increased. When cultured leiomyoma smc was treated with cAMP increasing agents as forskolin, an AC stimulating agent, or papaverin, a general PDE inhibitor, a considerable inhibition of DNA replication and protein synthesis was obtained.

    In the thh·d paper, a proliferation study was made on cultured benign prostate hyperplasia smc, were the mitogen effect of lysophosphatidic acid (LPA) and cAMP/cGMP increasing agents was investigated. LPA generated a dose-dependent mitogen response, which was efficiently inhibited, both by forskolin, and by papaverin. In addition, sildenafil (Viagra®), which serve as a potent and selective PDE5 inhibitor, also decreased the LPA mediated growth promotion in a dose dependent manner.

    The last study, demonstrate primarily the expression pattem of LPA receptors (Edg) in BPH smc. Further, the intracellular cAMP changes in LPA stimulated BPH smc and the proliferative effect of the LPA analogue sphingosine 1-phosphate (SIP) was considered. First, all Edg was identified with exception of Edg6. Moreover, the cAMP level was unchanged by LPA per se, whereas co-incubation with forskolin generated a rapid and transient response. Further, SIP generated a divergent response including a LPA equivalent mitogen effect at low concentrations whereas inhibition of DNA replication was obtained at higher concentrations.

    In summary, this project demonstrates that cyclic nucleotides inhibit smooth muscle hyperplasia/hypertrophy in the luogenital tract. These results also suggest that manipulation of cyclic nucleotide level using tissue specific PDE inhibitors might constitute a new therapeutic approach for hyperplasia/hypertrophy related diseases in the urogenital tract.

    List of papers
    1. Characterization of α2-Adrenoceptor Subtypes in Pregnant Human Myometrium
    Open this publication in new window or tab >>Characterization of α2-Adrenoceptor Subtypes in Pregnant Human Myometrium
    1998 (English)In: Gynecologic and Obstetric Investigation, ISSN 0378-7346, E-ISSN 1423-002X, Vol. 45, no 3, p. 145-150Article in journal (Refereed) Published
    Abstract [en]

    The aim of the present investigation was to determine which subtypes of the α2-adrenoceptors are being expressed in the human pregnant myometrium at term pregnancy. In radioligand binding studies, the specific binding of [3H]rauwolscine to human myometrial membranes was specific and of high affinity with Kd of 2.8 ± 0.6 nM and Bmax of 95 ± 5 fmol/mg protein. Results from competition for the binding of [3H]rauwolscine using subtype-selective ligands, oxymetazoline (α2A-subptype), chlorpromazine (α2B-subtype) and prazosin (α2B-α2C-subtype), suggested that the α2A- and α2B-subtypes are being co-expressed. In order to examine if also the α2C-subtype is being expressed we used an optimal concentration of oxymetazoline or chlorpromazine which would block the high-affinity site, equivalent to the α2A- and α2B-subtype respectively. Competition curves of both oxymetazoline and chlorpromazine still showed a significantly better fit using a two-site model, suggesting that the α2C-subtype also is being expressed. The expression of α2C-subtype mRNA was confirmed using reverse transcription-polymerase chain reaction on mRNA isolated from myometrial biopsies.

    In conclusion, our results suggest that all three subtypes of α2-adrenoceptors are being coexpressed in the human myometrium at term pregnancy and that α2-expression is dominated by the α2A-subtype.

    Keywords
    α2-Adrenergic receptors, Subtype, Myometrium, Human, Pregnancy, [3H]rauwolscine, Reverse transcription-polymerase chain reaction
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-80081 (URN)10.1159/000009944 (DOI)
    Available from: 2012-08-20 Created: 2012-08-20 Last updated: 2017-12-07Bibliographically approved
    2. Changes in β2-adrenoceptor expression and in adenylyl cyclase and phosphodiesterase activity in human uterine leiomyomas
    Open this publication in new window or tab >>Changes in β2-adrenoceptor expression and in adenylyl cyclase and phosphodiesterase activity in human uterine leiomyomas
    2000 (English)In: Molecular human reproduction, ISSN 1360-9947, E-ISSN 1460-2407, Vol. 6, no 9, p. 835-842Article in journal (Refereed) Published
    Abstract [en]

    Uterine leiomyoma is a very common benign tumour with unclear pathophysiology in adult women. In the present study we have investigated the expression level of α2- and β2-adrenoceptors, and the adenylyl cyclase and phosphodiesterase activity in leiomyoma tissue compared with adjacent myometrium. Our results show that the α22-adrenoceptor ratio is increased in leiomyoma, due to a significant decrease in β2-adrenoceptor expression. These changes were not due to an increased innervation, as the tumour tissue was completely devoid of nerve fibres. Moreover, the adenylyl cyclase activity of leiomyoma membranes was found to be ~50% lower, whereas the phosphodiesterase activity was significantly increased (by ~100%). We found that stimulating an increase in intracellular cyclic AMP, by adenylyl cyclase activity through β2-adrenoceptors (isoprenaline), by direct enzyme activation (forskolin), or by inhibition of phosphodiesterase activity (papaverine), potently blocked both protein and DNA synthesis in cultured leiomyoma smooth muscle cells. Our results imply the adrenoceptors might be involved in, or a consequence of, leiomyoma growth. The results also suggest a new interesting approach for leiomyoma pharmacotherapy.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-25070 (URN)10.1093/molehr/6.9.835 (DOI)9500 (Local ID)9500 (Archive number)9500 (OAI)
    Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13Bibliographically approved
    3. Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue: Sildenafil and papaverin generate inhibition
    Open this publication in new window or tab >>Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue: Sildenafil and papaverin generate inhibition
    2002 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 51, no 1, p. 50-58Article in journal (Refereed) Published
    Abstract [en]

    Background The endogenous substance lysophosphatidic acid (LPA) has been found to generate proliferation of cultured smooth muscle cells (SMC). Therefore, the effect of LPA on human benign prostate hyperplasia (BPH) could be of interest.

    Methods The proliferative effect of LPA on cultured human prostatic SMC from specimens obtained at trans-urethral resection of the prostate (TURP) because of BPH, was analyzed by [3H]-thymidine and [35S]-methionine incorporation. In addition, LPA stimulated BPH SMC were treated with papaverin, forskolin, sildenafil or zaprinast, well known to increase the intracellular level of cAMP or cGMP.

    Results LPA produced a dose-dependent increase in BPH SMC, both regarding DNA- and protein-synthesis with EC50 values of 3 and 10 μM, respectively. Furthermore, both papaverin, a general phosphodiesterase inhibitor regarding cAMP hydrolyzes, and forskolin, an adenylyl cyclase stimulating agent, inhibited the LPA-stimulated DNA replication in a dose dependent manner with IC50  = 2.5, and 0.35 μM, respectively. cGMP increasing agents, such as the NO-donors SIN-1 and SNAP, produced a weak anti-proliferative response. However, both phosphodiesterase 5 inhibitors sildenafil (Viagra®) and zaprinast efficiently blocked DNA replication. In addition, when the protein synthesis was examined, we found that the LPA response was significantly inhibited by forskolin and papaverin.

    Conclusions The major conclusion of this investigation is that the endogenous serum component LPA, is able to promote human BPH SMC growth. In addition, our study indicates that cyclic nucleotides can inhibit this effect. Future clinical studies will be needed to determine if different specific phosphodiesterase inhibitors per se or in combination could represent a new therapeutic possibility for the treatment of BPH.

    Keywords
    BPH, SMC, hyperplastic, PDE, AC, cAMP, cGMP, [H-3]-thymidine, [S-35]-methionine, proliferation
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-47887 (URN)10.1002/pros.10077 (DOI)
    Note
    On the day of the defence day the status of this article was submitted.Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13Bibliographically approved
    4. Characterization of EDG receptor expression and proliferative response in cultured human BPH smooth muscle cells
    Open this publication in new window or tab >>Characterization of EDG receptor expression and proliferative response in cultured human BPH smooth muscle cells
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    The endogenous phospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are both known to generate a Vvide variety of effects in various cell systems by the endothelial differentiation gene (Edg) receptor family, including 7 different G-protein coupled Edg receptors.

    In this study, expression of LPA- and SlP Edg receptors was examined, and so was the effect with respect to proliferation on cultured BPH smooth muscle cells smc. Mmeover, theresponse on cAMP levels was examined. Finally, a potential link between activation of the MAP kinase cascade and the LPA stimulated proliferation was investigated.

    First, the RT-PCR analysis of the Edg receptors in BPH smc, demonstrated a heterogeneous expression including all receptors except the Edg6 subtype. Further, in contrast to LPA, the mitogen effect of SIP, demonstrated a concentration-dependent biphasic response, including stimulation below 1μM, whereas inhibition was obtained at higher concentrations. Forskolin induced a rapid and transient cAMP response in LPA stimulated cells, with a peak-value after 3 minutes. After 15 minutes the cAMP level had retmned to base-line level. However a gradual increase to 15% of maximum value was obtained after additional 30 minutes, and thereafter a gradual reduction was observed. The mentioned antiproliferative response generated by SIP could not be conelated to an intracellular cAMP increase. Finally, when the LPA treated smc was co-incubated with the MAPK kinase inhibitor PD98059 (10 μM) the mitogen response was eliminated.

    The cAIVIP increase, which was induced by forskolin, corresponds with mentioned antiproliferative effect whereas a similar con-elation was not obtained regarding SIP. The intracellular signal mechanisms triggered by LPA and S1P in BPH smc remain to be further investigated.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-80084 (URN)
    Available from: 2012-08-20 Created: 2012-08-20 Last updated: 2012-08-20Bibliographically approved
  • 658.
    Adolfsson, Per
    et al.
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Ahlstrand, Christer
    Linköping University, Department of Clinical and Experimental Medicine, Urology. Linköping University, Faculty of Health Sciences.
    Varenhorst, Eberhard
    Linköping University, Department of Clinical and Experimental Medicine, Urology. Linköping University, Faculty of Health Sciences.
    Svensson, Samuel
    Linköping University, Department of Medical and Health Sciences, Pharmacology. Linköping University, Faculty of Health Sciences.
    Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue: Sildenafil and papaverin generate inhibition2002In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 51, no 1, p. 50-58Article in journal (Refereed)
    Abstract [en]

    Background The endogenous substance lysophosphatidic acid (LPA) has been found to generate proliferation of cultured smooth muscle cells (SMC). Therefore, the effect of LPA on human benign prostate hyperplasia (BPH) could be of interest.

    Methods The proliferative effect of LPA on cultured human prostatic SMC from specimens obtained at trans-urethral resection of the prostate (TURP) because of BPH, was analyzed by [3H]-thymidine and [35S]-methionine incorporation. In addition, LPA stimulated BPH SMC were treated with papaverin, forskolin, sildenafil or zaprinast, well known to increase the intracellular level of cAMP or cGMP.

    Results LPA produced a dose-dependent increase in BPH SMC, both regarding DNA- and protein-synthesis with EC50 values of 3 and 10 μM, respectively. Furthermore, both papaverin, a general phosphodiesterase inhibitor regarding cAMP hydrolyzes, and forskolin, an adenylyl cyclase stimulating agent, inhibited the LPA-stimulated DNA replication in a dose dependent manner with IC50  = 2.5, and 0.35 μM, respectively. cGMP increasing agents, such as the NO-donors SIN-1 and SNAP, produced a weak anti-proliferative response. However, both phosphodiesterase 5 inhibitors sildenafil (Viagra®) and zaprinast efficiently blocked DNA replication. In addition, when the protein synthesis was examined, we found that the LPA response was significantly inhibited by forskolin and papaverin.

    Conclusions The major conclusion of this investigation is that the endogenous serum component LPA, is able to promote human BPH SMC growth. In addition, our study indicates that cyclic nucleotides can inhibit this effect. Future clinical studies will be needed to determine if different specific phosphodiesterase inhibitors per se or in combination could represent a new therapeutic possibility for the treatment of BPH.

  • 659.
    Adolfsson, Per
    et al.
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Haug, Ingrid
    Linköping University, Department of Biomedicine and Surgery, Cell biology. Linköping University, Faculty of Health Sciences.
    Berg, Göran
    Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences.
    Svensson, Samuel
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Changes in β2-adrenoceptor expression and in adenylyl cyclase and phosphodiesterase activity in human uterine leiomyomas2000In: Molecular human reproduction, ISSN 1360-9947, E-ISSN 1460-2407, Vol. 6, no 9, p. 835-842Article in journal (Refereed)
    Abstract [en]

    Uterine leiomyoma is a very common benign tumour with unclear pathophysiology in adult women. In the present study we have investigated the expression level of α2- and β2-adrenoceptors, and the adenylyl cyclase and phosphodiesterase activity in leiomyoma tissue compared with adjacent myometrium. Our results show that the α22-adrenoceptor ratio is increased in leiomyoma, due to a significant decrease in β2-adrenoceptor expression. These changes were not due to an increased innervation, as the tumour tissue was completely devoid of nerve fibres. Moreover, the adenylyl cyclase activity of leiomyoma membranes was found to be ~50% lower, whereas the phosphodiesterase activity was significantly increased (by ~100%). We found that stimulating an increase in intracellular cyclic AMP, by adenylyl cyclase activity through β2-adrenoceptors (isoprenaline), by direct enzyme activation (forskolin), or by inhibition of phosphodiesterase activity (papaverine), potently blocked both protein and DNA synthesis in cultured leiomyoma smooth muscle cells. Our results imply the adrenoceptors might be involved in, or a consequence of, leiomyoma growth. The results also suggest a new interesting approach for leiomyoma pharmacotherapy.

  • 660.
    Adolfsson, Per I.
    et al.
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Ahlstrand, Christer
    Linköping University, Department of Biomedicine and Surgery, Urology. Linköping University, Faculty of Health Sciences.
    Varenhorst, Eberhard
    Linköping University, Department of Biomedicine and Surgery, Urology. Linköping University, Faculty of Health Sciences.
    Hultgren, Sitti
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Svensson, Samuel P. S.
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Characterization of EDG receptor expression and proliferative response in cultured human BPH smooth muscle cellsManuscript (preprint) (Other academic)
    Abstract [en]

    The endogenous phospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are both known to generate a Vvide variety of effects in various cell systems by the endothelial differentiation gene (Edg) receptor family, including 7 different G-protein coupled Edg receptors.

    In this study, expression of LPA- and SlP Edg receptors was examined, and so was the effect with respect to proliferation on cultured BPH smooth muscle cells smc. Mmeover, theresponse on cAMP levels was examined. Finally, a potential link between activation of the MAP kinase cascade and the LPA stimulated proliferation was investigated.

    First, the RT-PCR analysis of the Edg receptors in BPH smc, demonstrated a heterogeneous expression including all receptors except the Edg6 subtype. Further, in contrast to LPA, the mitogen effect of SIP, demonstrated a concentration-dependent biphasic response, including stimulation below 1μM, whereas inhibition was obtained at higher concentrations. Forskolin induced a rapid and transient cAMP response in LPA stimulated cells, with a peak-value after 3 minutes. After 15 minutes the cAMP level had retmned to base-line level. However a gradual increase to 15% of maximum value was obtained after additional 30 minutes, and thereafter a gradual reduction was observed. The mentioned antiproliferative response generated by SIP could not be conelated to an intracellular cAMP increase. Finally, when the LPA treated smc was co-incubated with the MAPK kinase inhibitor PD98059 (10 μM) the mitogen response was eliminated.

    The cAIVIP increase, which was induced by forskolin, corresponds with mentioned antiproliferative effect whereas a similar con-elation was not obtained regarding SIP. The intracellular signal mechanisms triggered by LPA and S1P in BPH smc remain to be further investigated.

  • 661.
    Adolfsson, Per I
    et al.
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
    Bloth, Björn
    Department of Clinical Neuroscience, Laboratory of Translational Neuropharmacology, Center of Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
    Hägg, Staffan
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Region Östergötland, Center for Diagnostics, Department of Clinical Pharmacology. Linköping University, Faculty of Health Sciences. Futurum Academy for Health and Care, Jönköping County Council, Sweden.
    Svensson, Samuel P S
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
    Zinc Induces a Bell-shaped Proliferative Dose-response Effect in Cultured Smooth Muscle Cells From Benign Prostatic Hyperplasia.2015In: Urology, ISSN 0090-4295, E-ISSN 1527-9995, Vol. 85, no 3, p. 704.e15-704.e19Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To investigate the effects of zinc (Zn(2+)) concentrations on cultured benign prostatic hyperplasia (BPH) smooth muscle cell (SMC) proliferation.

    METHODS: The effects of Zn(2+) were studied in primary cultures of human BPH SMC, stimulated with either 10-μM lysophosphatidic acid (LPA) or LPA in combination with 100-nM testosterone. Deoxyribonucleic acid replication and protein synthesis using [(3)H]-thymidine and [(35)S]-methionine incorporation were measured. Furthermore, studies were performed to evaluate if Zn(2+) could potentiate the inhibitory effect of phosphodiesterase-5 blockers, on BPH SMC proliferation.

    RESULTS: Zn(2+) generated a bell-shaped concentration response, both regarding deoxyribonucleic acid replication and protein synthesis in cultured BPH SMC. Below a threshold value (approximately 200 μM), a significant mitogenic effect was seen, whereas higher concentrations inhibited SMC proliferation after stimulation with LPA. This effect was even more pronounced after stimulation of LPA in combination with testosterone. Moreover, phosphodiesterase-5 inhibitors, that is, sildenafil blocked LPA-stimulated BPH SMC proliferation. This antiproliferative effect, was significantly potentiated by coincubation with Zn(2+) in an additative manner.

    CONCLUSION: The bell-shaped concentration response of Zn(2+) on cultured BPH SMC proliferation suggests that changes in prostate Zn(2+) concentrations, during aging, diet, or inflammatory conditions, may be of importance in the pathogenesis of BPH.

  • 662.
    Adolfsson, Per I.
    et al.
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Dahle, Lars Olav
    Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences.
    Berg, Göran
    Linköping University, Department of Molecular and Clinical Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences.
    Svensson, Samuel P. S.
    Linköping University, Department of Medicine and Care, Pharmacology. Linköping University, Faculty of Health Sciences.
    Characterization of α2-Adrenoceptor Subtypes in Pregnant Human Myometrium1998In: Gynecologic and Obstetric Investigation, ISSN 0378-7346, E-ISSN 1423-002X, Vol. 45, no 3, p. 145-150Article in journal (Refereed)
    Abstract [en]

    The aim of the present investigation was to determine which subtypes of the α2-adrenoceptors are being expressed in the human pregnant myometrium at term pregnancy. In radioligand binding studies, the specific binding of [3H]rauwolscine to human myometrial membranes was specific and of high affinity with Kd of 2.8 ± 0.6 nM and Bmax of 95 ± 5 fmol/mg protein. Results from competition for the binding of [3H]rauwolscine using subtype-selective ligands, oxymetazoline (α2A-subptype), chlorpromazine (α2B-subtype) and prazosin (α2B-α2C-subtype), suggested that the α2A- and α2B-subtypes are being co-expressed. In order to examine if also the α2C-subtype is being expressed we used an optimal concentration of oxymetazoline or chlorpromazine which would block the high-affinity site, equivalent to the α2A- and α2B-subtype respectively. Competition curves of both oxymetazoline and chlorpromazine still showed a significantly better fit using a two-site model, suggesting that the α2C-subtype also is being expressed. The expression of α2C-subtype mRNA was confirmed using reverse transcription-polymerase chain reaction on mRNA isolated from myometrial biopsies.

    In conclusion, our results suggest that all three subtypes of α2-adrenoceptors are being coexpressed in the human myometrium at term pregnancy and that α2-expression is dominated by the α2A-subtype.

  • 663. Adolfsson, R.
    et al.
    Karlsson, Thomas
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences, Cognition, Development and Disability.
    Minnesstörningar vid alkoholmissbruk ("Memory disturbances following alcohol abuse")1987In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 84, p. 3923-3926Article in journal (Refereed)
  • 664.
    Adolfsson, Sofie
    Linköping University, Department of Computer and Information Science.
    ’The Big Five of Teamwork’ i en flygtrafikledningsdomän: En observationsstudie på Arlanda ATCC2018Independent thesis Basic level (degree of Bachelor), 12 credits / 18 HE creditsStudent thesis
    Abstract [en]

    Today, many industries are dependent on a solid teamwork. However, there is a need for objective measurement assessment for teamwork and therefore this project aims to create and test an observation protocol based on the theoretical model ’The Big Five of Teamwork’ compiled by Salas, Sims & Burke (2005). The observation protocol was used to observe teamwork between two air traffic controllers at Arlanda ATCC. After the observations the air traffic controllers answered a survey to receive subjective aspects from the model. A total of 15 structured observations were conducted. The results revealed that it’s possible to estimate teamwork on air traffic controllers using an observation protocol based on six of eight components, where team orientation and shared mental model were not included. The components appeared to be more than just an observable behavior, thus only observations does not give a fair picture of the component. The result also showed that air traffic controllers themselves perceive all components as a part of the work. The observations showed that the cooperation could look different and differ from team to team, and that air traffic controllers adapt to each other’s needs. 

  • 665.
    Adolfsson, Stella
    et al.
    Linköping University, Department of Educational Science (IUV).
    Hult, Camilla
    Linköping University, Department of Educational Science (IUV).
    Med språket som verktyg: En jämförande studie om språkförståelse hos svenska elever och invandrarelever i nionde klass.1999Independent thesis Basic level (professional degree)Student thesis
    Abstract [sv]

    För att integreras i samhället och för att kunna ta del av medborgerliga rättigheter krävs goda språkkunskaper. Goda språkkunskaper är också ett måste för att invandrarelever ska kunna tillgodogöra sig undervisningen i skolan på ett tillfredsställande sätt. Syftet med det här examensarbetet är att undersöka språkförståelsen hos grundskoleelever med invandrarbakgrund. För att uppnå vårt syfte har vi gjort dels en litteraturstudie, dels en undersökning av språkförståelse hos elever i nionde klass. Av litteraturstudien framgår att många elever med invandrarbakgrund har brister i det svenska språket. Det framgår även att det är lätt att överskatta många invandrarelevers färdighet i svenska, eftersom de klarar talspråket bra. Många gånger saknar dock invandrarelever djupare kunskap i det svenska språket och de har även brister i ordförrådet. I vår undersökning ingår 10 svenska elever och 10 elever med invandrarbakgrund, slumpmässigt utvalda från en skola. Dessa genomförde tester av ordförståelse, textförståelse och begreppsförståelse baserat på en lärobokstext i historia. Resultaten visar på en sämre språkförståelse i svenska hos invandrareleverna jämfört med de svenska eleverna. Skillnaden mellan de båda grupperna är speciellt markant när det gäller ordförståelse.

  • 666.
    Adolfsson, Tim
    et al.
    Linköping University, Department of Management and Engineering, Political Science.
    Eriksson, Adam
    Den mediala diskursordningen i förändring: En jämförande kritisk diskursanalys av medias framställning av Sverigedemokraterna.2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The Sweden democrats has for a long time been labelled as a racist party in swedish media. Due to the problems related to the members of the party in the 90s, where members were subject to criminal actions and racist scandals, the media had focus on the racist actions and labelled the party as a racist party therefore. How does the discourse present itself today? The purpose is to make a comparative study between the year 2014 and 2018/2019 and to research if the discourse surrounding the sweden democrats has changed during this time. Relevance for the study is how we discover, categorize and give the discourses names that helps us and also the reader to understand the process about how the media picture Sweden democrats. Our method is a comparative critical discourse analysis that we are going to use on articles published in the two largest newspapers in sweden, Aftonbladet and Expressen. We will locate the surrounding discourses from 2014 at first and then locate what kind of discourses is surrounding the party in 2018/2019. The main discourse from 2014 is the racist discourse, it´s present in nearly every article we analyse. With the racist discourse, the big difference is that the discourse is changing. When we look upon 2018/2019, new discourses take place, the new discourses we locate it’s the right populism-, scandal- and normalization discourse, the rasism discourse is still present but not so extensive as during 2014. During 2014 the racism discourse depends on the scandal discourse, this changes significant, the scandal discourse is no longer in 2018/2019 dependent on the racism discourse, but it acutally transforms into its own discourse. The focus on racism is almost gone and new scandals take place instead. In combination with the normalization discourse we can se that there has been a change, actually a big change in the media discourse surrounding the Sweden democrats.

  • 667.
    Adolfsson, Tommy
    Linköping University, Department of Educational Science (IUV).
    "prygel eller pjosk"Folkskollärarna och disciplinfrågan 1950-19641999Independent thesis Basic level (professional degree)Student thesis
    Abstract [sv]

    Under åren 1946-1962 förändras Sveriges obligatoriska skolväsende i grunden. Hur såg lärarna på de frågor som rörde disciplinen i skolan och hur menade de att problemen hade uppstått samt hur skulle problemen lösas på både kort och på lång sikt. Analysen tar upp vad folkskollärarna debatterar om disciplinproblemen under 1950-talet till och med 1964. Analysen görs utifrån folkskollärarnas tidning och lärartidningen.

  • 668.
    Adolfsson, Victor
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Thyberg, Jan
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Utveckling av en e-utbildningsapplikation för mobiltelefoner2008Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The web production bureau Houdini develops solutions, among other things, for electronic learning. This form of education relies on electronic devices, and is often interactive. In the past, Houdini has mostly developed e-learning for computers. However, Houdini are now looking to explore the concept of developing e-learning for mobile phones.

    It was decided that a software prototype for mobile phones was to be developed by using an iterative and user-centered system design process. A prototype was developed through incremental and evolutionary prototyping. It was evaluated together with users throughout the development process.

    The work lead to an application for mobile phones, where users can watch educational films. The films are streamed via the Internet to the mobile phone. During the course of the education, the user can complete exercises. In order to complete the education, the user has to pass a final test.

    The prototype shows that the technology is mature enough for one to be able to develop a well-functioning e-learning application for mobile phones. What is needed are companies that are willing to invest in the idea.

  • 669.
    Adrian, Christoffer
    et al.
    Linköping University, Department of Management and Engineering, Business Administration .
    Kinnunen, Sanna
    Linköping University, Department of Management and Engineering, Business Administration .
    Aktieindexobligationer: För vem är aktieindexobligationer en passande investering?2010Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: Since the introduction in the early 1990s, the volume of newly issued equity index bonds overall had a positive development. This increase indicates that the product has become a popular form of savings among Swedes. Together with the fact that there are few studies done on equity index bonds as a savings product. A wider perspective has been taken into account which makes the subject interesting to study.

    Aim: Purpose of this study is to identify and analyze for who private investors equity index bonds fit as a savings product on lifecycle thought based on (i) professional and consulting practices, (ii) financial risk management theory, focusing on portfolio theory, and (iii) historical data on risk and return.

    Completion: The study was completed using interviews with private consultants, capital advisors and people working with structured products at major banks and of small players. In addition, five stereotypes were used as a basis for discussion during the interviews. In order to conduct a deeper analysis of the product as a form of saving for private investors, a portfolio optimization carried out taking the historical data on risk and return into account.

    Conclusion: The study determines that the product is suitable for private investors who are in the latter part of the consolidation phase and mainly not prone to risk. The study suggests that equity index bonds primarily are associated with credit- and market risk, while the risk of the product is assessed as low. The study also indicates that the properties that are added to investors’ portfolios are low risk and a potential aspect.

  • 670.
    Adrian, Stine
    Linköping University, Faculty of Arts and Sciences. Linköping University, The Tema Institute, The Department of Gender Studies.
    Nye skabelsesberetninger om æg, sæd og embryoner: Et etnografisk studie af skabelser på sædbanker og fertilitetsklinikker2006Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This thesis investigates the use of assisted reproduction in Denmark and Sweden. Assisted reproduction is fascinating, because it enables the creation of children who would not have been born otherwise. At the same time, it challenges existing norms concerning sexuality, ethnicity, normality, age, gender and kinship. The processes of creation and change that take place at fertility clinics and sperm banks are analyzed by exploring the encounters between norms, patients, employees, technology and gametes. The analysis shows how legislators, patients and employees relate to and manage the use of these technologies. It illustrates that the predominant principle used for setting ethical limits is the mimicking of nature. However, this principle is constantly negotiated and changed. One reason is that negotiations take place in an encounter with the agency of the technology, gametes and body. Another reason for the change of the naturalization principle is that absurd situations, such as stigmatization and marginalization of patients and their technologically conceived children, take place. The empirical analysis also contributes to a theoretical understanding of how materialization processes (creation processes) take place in the encounters between discourse and material agency. The thesis is written with a point of departure in feminist science studies, and can be read as a contribution to feminist new materialist theory and method.

  • 671.
    Adrian, Stine
    et al.
    Linköping University, The Tema Institute, The Department of Gender Studies. Linköping University, Faculty of Arts and Sciences.
    Gustavson, MalenaLinköping University, The Tema Institute, The Department of Gender Studies. Linköping University, Faculty of Arts and Sciences.Lykke, NinaLinköping University, The Tema Institute, The Department of Gender Studies. Linköping University, Faculty of Arts and Sciences.
    GEXcel Work in Progress Report Volume I: Proceedings from GEXcel Kick-off Conference2007Conference proceedings (editor) (Other academic)
    Abstract [en]

    The report gives an introduction to the Linköping-Örebro Centre of Gender Excellence: GEXcel - Gendering EXcellence: Towards a European Centre of Excellence in Transnational and Transdisciplinary Studies of Changing Gender Relations, Intersectionalities and Embodiment.

  • 672.
    Adrodegari, Federico
    et al.
    University of Brescia, Italy.
    Saccani, Nicola
    University of Brescia, Italy.
    Kowalkowski, Christian
    Linköping University, Department of Management and Engineering, Industrial Economics. Linköping University, Faculty of Science & Engineering. Hanken School Econ, Finland.
    A framework for PSS business models: formalization and application2016In: PRODUCT-SERVICE SYSTEMS ACROSS LIFE CYCLE, ELSEVIER SCIENCE BV , 2016, Vol. 47, p. 519-524Conference paper (Refereed)
    Abstract [en]

    In order to successfully move "from products to solutions", companies need to redesign their business model. Nevertheless, service oriented BMs in product-centric firms are under-investigated in the literature: very few works develop a scheme of analysis of such BMs. To provide a first step into closing this gap, we propose a new framework to describe service-oriented BMs, pointing out the main BM components and related PSS characteristics. Thus, the proposed framework aims to help companies to take into account the relevant elements that need to be designed to successfully implement a service-oriented BM and thus guide strategic decisions. (C) 2016 The Authors. Published by Elsevier B.V.

  • 673.
    Adrodegari, Federico
    et al.
    University of Brescia, Italy.
    Saccani, Nicola
    University of Brescia, Italy.
    Kowalkowski, Christian
    Linköping University, Department of Management and Engineering, Industrial Economics. Linköping University, Faculty of Science & Engineering. Hanken School Econ, Finland.
    Vilo, Jyrki
    KINE Robot Solut, Finland.
    PSS business model conceptualization and application2017In: Production planning & control (Print), ISSN 0953-7287, E-ISSN 1366-5871, Vol. 28, no 15, p. 1251-1263Article in journal (Refereed)
    Abstract [en]

    The discussion about business models has gained considerable attention in the last decade. Business model frameworks have been developed in the literature as management methods helping companies to comprehend and analyse their current business logic and guide the deployment of new strategies. In response to calls for a deeper understanding of the application of a business model approach to product-service systems (PSS), this study develops a two-level hierarchical framework that (i) includes a set of components with pertinent, second-order variables to take into account when undergoing the shift from products to solutions; (ii) supports industrial companies, especially SMEs, in designing their future business model and in consistently planning the actions needed to implement it. The framework was applied and refined within real-life settings. The application to KINE - a robot solutions supplier - shows how key challenges faced by servitization firms may be thoroughly addressed through the adoption of a business model perspective.

  • 674.
    Adsten, M
    et al.
    Univ Uppsala, Angstrom Lab, S-75121 Uppsala, Sweden Linkoping Univ, Dept Phys & Measurement Technol, S-58183 Linkoping, Sweden.
    Joerger, R
    Univ Uppsala, Angstrom Lab, S-75121 Uppsala, Sweden Linkoping Univ, Dept Phys & Measurement Technol, S-58183 Linkoping, Sweden.
    Järrendahl, Kenneth
    Linköping University, The Institute of Technology.
    Wackelgard, E
    Univ Uppsala, Angstrom Lab, S-75121 Uppsala, Sweden Linkoping Univ, Dept Phys & Measurement Technol, S-58183 Linkoping, Sweden.
    Optical characterization of industrially sputtered nickel-nickel oxide solar selective surface2000In: Solar Energy, ISSN 0038-092X, E-ISSN 1471-1257, Vol. 68, no 4, p. 325-328Article in journal (Refereed)
    Abstract [en]

    Tandem absorbers are often used in the design of solar absorbers for photo thermal conversion. They consist of a thin coating, selectively absorbing in the wavelength range of the solar spectrum, on a metal substrate. The optical performance of a tandem absorber depends on the optical constants and thickness of the absorbing coating and also on the reflectivity of the underlying metal. A very high solar absorptance is achieved when the coating has a non-uniform composition in the sense that the refractive index is highest closest to the metal substrate and then gradually decreases towards the front surface. This type of composition suppresses coating interference and gives a low front surface reflection if the refractive index at the front surface is low. We report on optical analysis of a, Solar absorber with a graded index coating of sputtered nickel-nickel oxide deposited on aluminium. The optical constants have been determined from reflectance, transmittance and ellipsometry data by fitting the data to a two-layer model of the coating. The optical constants of the two layers can be regarded as effective optical constants for the lower and upper part of the graded index coating respectively. It is found that the effective refractive index of the top layer is somewhat tower than for the base layer. The extinction coefficient is higher in the lower part of the coating. Both effective refractive index and extinction coefficient of the base layer increase monotonically with increasing wavelength as for metallic materials. (C) 2000 Elsevier Science Ltd. All rights reserved.

  • 675.
    Adua, Eric
    et al.
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Oteng Danso, Frank
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Mensah Boa-Amponsem, Oswald
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Adusei-Mensah, Frank
    University of Cape Coast, Ghana.
    Effect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages2015In: Iranian Journal of Immunology, ISSN 1735-1383, E-ISSN 1735-367X, Vol. 12, no 2, p. 94-103Article in journal (Refereed)
    Abstract [en]

    Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whether the entry of neutrophils and release of arginase can interfere with nitric oxide production from stimulated mouse macrophages. Methods: Neutrophils were isolated from human blood and stimulated with cytodex-3 beads. Cultured macrophages were stimulated with lipopolysaccharide and interferon gamma with or without N (G)-nitro-L-arginine methyl ester or N (omega)-hydroxy-nor-L-arginine. Measurement of NO2-/NO3- and urea were done using the spectrophotometer. Results: A significantly higher level of nitric oxide production from stimulated macrophages was observed compared to control. There was a decrease in nitric oxide production when stimulated macrophages were treated with the supernatant from activated neutrophils (pless than0.05). Conclusion: Arginase from neutrophils can modulate nitric oxide production from activated macrophages which may affect the course of infection by intracellular bacteria.

  • 676.
    Adén, Sebastian
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Modellbaserad diagnostik tillämpad för hydrauliska applikationer2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [sv]

    I en globaliserad värld där produktägare finner sina produkter på alltmer avslägsna platser, ökar behovet av att på ett så ekonomiskt och tidseffektivt sätt som möjligt, utföra reperationer och underhållningsarbeten. Att erbjuda en stark och mer effektiv eftermarknadssupport kan öka företagens konkurrenskraft och framför allt göra dem kostnadseffektiva med avseende på lägre bemanningsstyrka. Ett sätt att underlätta underhållningsarbetet är genom att använda modellbaserad diagnos för att generera underlag vid exempelvis reperationsarbeten.

    Denna rapport undersöker möjligheterna att utifrån en modell av en hydraulisk applikation, utföra autogenererad diagnostik bland annat iform av felträdsanalys.

    Innehållet i rapporten beskriver även hur modelleringsarbetet har gått till och utveckling av modellens ingående komponenter.

    Examensarbetet är utfört på Combitech AB, Linköping. 

  • 677.
    Aeppli, Christoph
    et al.
    Stockholm University, Sweden .
    Bastviken, David
    Linköping University, The Tema Institute, Department of Water and Environmental Studies. Linköping University, Faculty of Arts and Sciences.
    Andersson, Per
    Swedish Museum Nat Hist, Sweden .
    Gustafsson, Orjan
    Stockholm University, Sweden .
    Chlorine Isotope Effects and Composition of Naturally Produced Organochlorines from Chloroperoxidases, Flavin-Dependent Halogenases, and in Forest Soil2013In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 47, no 13, p. 6864-6871Article in journal (Refereed)
    Abstract [en]

    The use of stable chlorine isotopic signatures (delta Cl-37) of organochlorine compounds has been suggested as a tool to determine both their origins and transformations in the environment. Here we investigated the delta Cl-37 fractionation of two important pathways for enzymatic natural halogenation: chlorination by chloroperoxidase (CPO) and flavin-dependent halogenases (FDH). Phenolic products of CPO were highly Cl-37 depleted (delta Cl-37 = -12.6 +/- 0.9 parts per thousand); significantly more depleted than all known industrially produced organochlorine compounds (delta Cl-37 = -7 to +6 parts per thousand). In contrast, four FDH products did not exhibit any observable isotopic shifts (delta Cl-37 = -0.3 +/- 0.6 parts per thousand). We attributed the different isotopic effect to the distinctly different chlorination mechanisms employed by the two enzymes. Furthermore, the delta Cl-37 in bulk organochlorines extracted from boreal forest soils were only slightly depleted in Cl-37 relative to inorganic Cl. In contrast to previous suggestions that CPO plays a key role in production of soil organochlorines, this observation points to the additional involvement of either other chlorination pathways, or that dechlorination of naturally produced organochlorines can neutralize delta Cl-37 shifts caused by CPO chlorination. Overall, this study demonstrates that chlorine isotopic signatures are highly useful to understand sources and cycling of organochlorines in nature. Furthermore, this study presents delta Cl-37 values of FDH products as well of bulk organochlorines extracted from pristine forest soil for the first time.

  • 678.
    Aeppli, Christoph
    et al.
    Stockholm University.
    Holmstrand, Henry
    Stockholm University.
    Bastviken, David
    Linköping University, The Tema Institute, Department of Water and Environmental Studies. Linköping University, Faculty of Arts and Sciences.
    Tysklind, Mats
    Umeå University.
    Gustafsson, Orjan
    Stockholm University.
    Investigating formation and degradation of polychlorinated phenols in the environment using chlorine and carbon stable isotope fractionation in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol 242, issue , pp2011In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA , 2011, Vol. 242Conference paper (Refereed)
    Abstract [en]

    n/a

  • 679.
    Aerts, Joel
    et al.
    University of Liege, Belgium; University of Paris 07, France.
    Ballinger, James R.
    Guy's and St Thomas' Hospital, London, UK.
    Behe, Martin
    ETH PSI USZ Paul Scherrer Institute, Villigen-PSI, Switzerland.
    Decristoforo, Clemens
    Innsbruck Medical University, Austria.
    Elsinga, Philip H.
    University of Groningen, Netherlands.
    Faivre-Chauvet, Alain
    CHU Nantes, France.
    Mindt, Thomas L.
    University Hospital Basel, Switzerland.
    Kolenc Peitl, Petra
    University Medical Centre Ljubljana, Slovenia.
    Todde, Sergio C.
    University of Milano-Bicocca, Italy.
    Koziorowski, Jacek
    Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics.
    Guidance on current good radiopharmacy practice for the small-scale preparation of radiopharmaceuticals using automated modules: a European perspective2014In: Journal of labelled compounds & radiopharmaceuticals, ISSN 0362-4803, E-ISSN 1099-1344, Vol. 57, no 10, p. 615-620Article in journal (Refereed)
    Abstract [en]

    This document is meant to complement Part B of the EANM Guidelines on current good radiopharmacy practice (cGRPP) in the preparation of radiopharmaceuticals issued by the Radiopharmacy Committee of the European Association of Nuclear Medicine, covering small-scale in-house preparation of radiopharmaceuticals with automated modules. The aim is to provide more detailed and practice-oriented guidance to those who are involved in the small-scale preparation of radiopharmaceuticals, which are not intended for commercial purposes or distribution.

  • 680.
    Aerts, Marc
    et al.
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics.
    Minalu, Girma
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics.
    Bösner, Stefan
    Department of General Practice and Family Medicine, Philipps University Marburg, Germany..
    Buntinx, Frank
    Department of Public Health and Primary Care, KU Leuven, Belgium; Department of General Practice, Maastricht University, The Netherlands..
    Burnand, Bernard
    Institute of Social and Preventive Medicine, Lausanne University Hospital, Switzerland..
    Haasenritter, Jörg
    Department of General Practice and Family Medicine, Philipps University Marburg, Germany..
    Herzig, Lilli
    Institute of Family Medicine, University of Lausanne, Switzerland..
    Knottnerus, J André
    Department of General Practice, Maastricht University, The Netherlands..
    Nilsson, Staffan
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Primary Care Center, Primary Health Care Center Vikbolandet.
    Renier, Walter
    Department of Public Health and Primary Care, KU Leuven, Belgium.
    Sox, Carol
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, USA..
    Sox, Harold
    Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH , USA; Patient-Centered Outcomes Research Institute, Washington, USA..
    Donner-Banzhoff, Norbert
    Department of General Practice and Family Medicine, Philipps University Marburg, Germany..
    Pooled individual patient data from five countries were used to derive a clinical prediction rule for coronary artery disease in primary care.2017In: Journal of Clinical Epidemiology, ISSN 0895-4356, E-ISSN 1878-5921, Vol. 81, p. 120-128Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To construct a clinical prediction rule for coronary artery disease (CAD) presenting with chest pain in primary care.

    STUDY DESIGN AND SETTING: Meta-Analysis using 3,099 patients from five studies. To identify candidate predictors, we used random forest trees, multiple imputation of missing values, and logistic regression within individual studies. To generate a prediction rule on the pooled data, we applied a regression model that took account of the differing standard data sets collected by the five studies.

    RESULTS: The most parsimonious rule included six equally weighted predictors: age ≥55 (males) or ≥65 (females) (+1); attending physician suspected a serious diagnosis (+1); history of CAD (+1); pain brought on by exertion (+1); pain feels like "pressure" (+1); pain reproducible by palpation (-1). CAD was considered absent if the prediction score is <2. The area under the ROC curve was 0.84. We applied this rule to a study setting with a CAD prevalence of 13.2% using a prediction score cutoff of <2 (i.e., -1, 0, or +1). When the score was <2, the probability of CAD was 2.1% (95% CI: 1.1-3.9%); when the score was ≥ 2, it was 43.0% (95% CI: 35.8-50.4%).

    CONCLUSIONS: Clinical prediction rules are a key strategy for individualizing care. Large data sets based on electronic health records from diverse sites create opportunities for improving their internal and external validity. Our patient-level meta-analysis from five primary care sites should improve external validity. Our strategy for addressing site-to-site systematic variation in missing data should improve internal validity. Using principles derived from decision theory, we also discuss the problem of setting the cutoff prediction score for taking action.

  • 681.
    Aerts, Sven
    et al.
    Fundamenten van de Exacte WetenschappenVrije Universiteit Brussel, Triomflaan 21050 Brussel, Belgium.
    Kwiat, Paul
    P-23, MS-H803, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
    Larsson, Jan-Åke
    Linköping University, Department of Mathematics, Applied Mathematics. Linköping University, The Institute of Technology.
    Zukowski, Marek
    Instytut Fizyki Teoretycznej i Astrofizyki, Uniwersytet Gdańsk, iPL-80-952 Gdańsk, Poland.
    Comment on Two-photon Franson-type experiment and local realism - Reply2001In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 86, no 9, p. 1909-1909Article in journal (Refereed)
    Abstract [en]

    A Reply to the Comment by Carlos Luiz Ryff.

  • 682.
    Aerts, Sven
    et al.
    Fundamenten van de Exacte Wetenschappen, Vrije Universiteit Brussel, Brussel, Belgium.
    Kwiat, Paul
    Los Alamos National Laboratory, Los Alamos, New Mexico.
    Larsson, Jan-Åke
    Linköping University, Department of Mathematics. Linköping University, The Institute of Technology.
    Zukowski, Marek
    Instytut Fizyki Teoretycznej i Astrofizyki Uniwersytet Gdański, Gdańsk, Poland .
    Two-photon Franson-type experiments and local realism1999In: Physical Review Letters, ISSN 0031-9007, E-ISSN 1079-7114, Vol. 83, no 15, p. 2872-2876Article in journal (Refereed)
    Abstract [en]

    The two-photon interferometric experiment proposed by J. D. Franson [Phys. Rev. Lett. 62, 2205 (1989)] is often treated as a “Bell test of local realism.” However, it has been suggested that this is incorrect due to the 50% postselection performed even in the ideal gedanken version of the experiment. Here we present a simple local hidden variable model of the experiment that successfully explains the results obtained in usual realizations of the experiment, even with perfect detectors. Furthermore, we also show that there is no such model if the switching of the local phase settings is done at a rate determined by the internal geometry of the interferometers.

  • 683.
    Aesoy, R.
    et al.
    Department of Oncology/Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden.
    Sanchez, B.C.
    Department of Oncology/Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden.
    Norum, J.H.
    Department of Pharmacology, University of Oslo, Oslo, Norway.
    Lewensohn, R.
    Department of Oncology/Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden.
    Viktorsson, K.
    Department of Oncology/Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden.
    Linderholm, Barbro
    Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    An autocrine VEGF/VEGFR2 and p38 signaling loop confers resistance to 4-hydroxytamoxifen in MCF-7 breast cancer cells2008In: Molecular Cancer Research, ISSN 1541-7786, E-ISSN 1557-3125, Vol. 6, no 10, p. 1630-1638Article in journal (Refereed)
    Abstract [en]

    Tamoxifen, a partial estrogen receptor antagonist, is part of the standard treatment of both primary and advanced breast cancers. However, significant proportions of breast cancers are either de novo resistant or develop tamoxifen resistance during the course of treatment through mechanisms which have been only partly characterized. We have previously found that high vascular endothelial growth factor (VEGF) or VEGF receptor 2 (VEGFR2) expression and concomitant high p38 mitogen-activated protein kinase activity within breast cancers predict a poor outcome for tamoxifen-treated patients. Here, we have molecularly dissected how VEGF/VEGFR2 and p38 are linked, and contribute to tamoxifen resistance within breast cancer using a MCF-7 BC cell model with different 4-hydroxytamoxifen (4-OHT) responsiveness. We report that MCF-7 breast cancer cell lines with tamoxifen resistance have increased secretion of VEGF and increased signaling through VEGFR2 compared with parental MCF-7 cells. 4-OHT treatment caused the ablation of VEGF secretion in parental MCF-7 cells, whereas in the tamoxifen-resistant subline, a VEGF/ VEGFR2 signaling loop was still evident upon treatment. Increased basal levels of total and phosphorylated p38 were observed in tamoxifen-resistant cells. Pharmacologic inhibition of p38 reduced the proliferation of both tamoxifen-responsive and tamoxifen-resistant cells and showed an additive growth-inhibitory effect in combination with 4-OHT. A connection between VEGF/ VEGFR2 and p38 signaling was identified by VEGF and VEGFR2 knockdown, which equally reduced both the total and the active forms of p38 in tamoxifen-resistant cells. Taken together, our results suggest that decreased sensitivityto 4-OHT is caused by a death-protecting VEGF/VEGFR2 and p38 growth factor loop in breast cancer cells. Inhibition of these signaling pathways may be beneficial to overcome tamoxifen resistance. Copyright © 2008 American Association for Cancer Research.

  • 684.
    Aevan, Nadjib Danial
    Linköping University, Department of Management and Engineering, Fluid and Mechatronic Systems.
    MDO Framework for Design of Human PoweredPropellers using Multi-Objective Genetic Algorithm2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis showcases the challenges, downsides and advantages to building a MultiDisciplinary Optimization (MDO) framework to automate the generation of an efficientpropeller design built for lightly loaded operation, more specifically for humanpowered aircrafts. Two years ago, a human powered aircraft project was initiatedat Linköping University. With the help of several courses, various students performedconceptional design, calculated and finally manufactured a propeller bymeans of various materials and manufacturing techniques. The performance ofthe current propeller is utilized for benchmarking and comparing results obtainedby the MDO process.The developed MDO framework is constructed as a modeFRONITER project wereseveral Computer Aided Engineering softwares (CAE) such as MATLAB, CATIAand XFOIL are connected to perform multiple consequent optimization subprocesses.The user is presented with several design constraints such as blade quantity,required input power, segment-wise airfoil thickness, desired lift coefficientetc. Also, 6 global search optimization algorithms are investigated to determinethe one which generate most efficient result according to several set standards.The optimization process is thereafter initialized by identifying the most efficientchord distribution with a help of an initial blade cross-section which has been previouslyused in other human powered propellers, the findings are thereafter usedto determine the flow conditions at different propeller stations. Two different aerodynamicoptimized shapes are generated with the help of consecutively performedsubprocesses. The optimized propeller requires 7.5 W less input power to generatenearly equivalent thrust as the original propeller with a total efficiency exceedingthe 90 % mark (90.25 %). Moreover, the MDO framework include an automationprocess to generate a CAD design of the optimized propeller. The generatedCAD file illustrates a individual surface blade decrease of 12.5 % compared tothe original design, the lightweight design and lower input power yield an overallpropulsion system which is less tedious to operate.

  • 685.
    A.F. Da, Silva
    et al.
    Instituto de Física, Universidade Federal da Bahia, Ondina, Salvador-Ba, 40210-340, Brazil.
    Meira, M.V.C.
    Instituto de Física, Universidade Federal da Bahia, Ondina, Salvador-Ba, 40210-340, Brazil, CETEC-Universidade Federal do Recôncavo da Bahia, Cruz das Almas-Ba, 44380-000, Brazil.
    Baldissera, G.
    Department of Materials Science and Engineering, Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
    Persson, C.
    Department of Materials Science and Engineering, Royal Institute of Technology, SE-100 44 Stockholm, Sweden.
    Gutman, N.
    Racah Institute of Physics, Center for Nanoscience and Nanotechnology, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
    Saar, A.
    Institute of Physics, Center for Nanoscience and Nanotechnology, Hebrew University of Jerusalem, Jerusalem 91904, Israel.
    Klason, P.
    Department of Physics, Göteborg University, SE-412 96 Göteborg, Sweden.
    Willander, Magnus
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Canestraro, C.D.
    Department of Materials Science and Engineering, Royal Institute of Technology, SE-100 44 Stockholm, Sweden, Departamento de Física, Universidade Federal do Paraná, Curitiba-PR, 81531-990, Brazil.
    Moreno, T.V.
    Departamento de Física, Universidade Federal do Paraná, Curitiba-PR, 81531-990, Brazil.
    Roman, L.S.
    Departamento de Física, Universidade Federal do Paraná, Curitiba-PR, 81531-990, Brazil.
    Growth, electrical and optical properties of SnO2: F on ZnO, Si and porous Si structures2009In: Nanotechnology 2009: Fabrication, Particles, Characterization, MEMS, Electronics and Photonics - Technical Proceedings of the 2009 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2009, CRC Press, 2009, Vol. 1, p. 352-355Conference paper (Refereed)
    Abstract [en]

    In this work we have analyzed the optical absorption of the ZnO and SnO2:F (FTO) films and applied them in porous silicon light-emitting diodes. The absorption and energy gap were calculated by employing the projector augmented wave method [1] within the local density approximation and with a modeled on-site self-interaction-like correction potential within the LDA+U SIC [2]. Experiment and theory show a good agreement when the optical absorption and optical energy gap are considered. A layer of FTO is deposited by spray pyrolysis on top of porous Si (PSi) or ZnO/(PSi) in order to make the LEDs. The morphology and roughness of the films are analyzed by Atomic Force Microscopy before and after the FTO deposition. The electrical and optical properties are studied by characteristics curves J × V, and electroluminescence intensity versus bias.

  • 686. af Forselles, J.
    et al.
    von Eckardstein, S.
    Stegeryd, Y.
    Svanström, M.
    Ansell, Ricky
    Linköping University, Department of Physics, Chemistry and Biology, Molecular genetics . Linköping University, The Institute of Technology.
    Integration of rape case related information in the electronic communication between the Swedish police and the forensic laboratory2009In: Book of Abstracts, 2009, p. 126-Conference paper (Refereed)
  • 687.
    af Klercker, Tom
    Linköping University, Department of Department of Health and Society, General Practice. Linköping University, Faculty of Health Sciences.
    Method for inductive case-based decision support system over the Internet: exemplified by ear, nose and throat diagnostics in primary care1997Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This thesis is an example of an ear to loaf process:

    A Preliminary Essential Data Set (PEDS) for Ear, Nose and Throat (ENT) diagnostics in Primary Health Care (PHC) was established by infologic modelling of existing tractates, between the specialist organisations of ENT and PHC, and four contemporary text-books on the subject (I). The PEDS was then compared to the aggregated data from a sample of case-files from a Swedish PHC centre. The quality of the individual medical record was found to be poor and not sufficient for follow-up and Quality Management (QM) purposes (II). The aggregated data from the case-file sample was processed by an inductive "expert" computer program that generated a decision-tree, based on the total number of decisions (diagnoses) in the data-base. This was nearly identical to the PEDS and somewhat less complicated. Infological modelling of the PEDS and the decision-tree resulted in the proposed Essential Data Set (EDS) for ENT diagnostics in PHC. The decision tree was "pruned" to achieve simplicity and ease of use (III). It was converted into a Computer-aided Decision Support System (CDSS) and put on the Internet using World Wide Web (WWW) tools (IV). This system was then implemented in the Skänninge PHC centre where an Electronic Medical Record System (EMRS) was in everyday use. Due to technical difficulties no integration between the two systems was possible. The CDSS was run on a computer outside the centre and this raised the question of secrecy and security (V). Prior to the implementation, and after a study period of four months attitudes towards, and the acceptance of, new Information Technology (IT) was explored by using focus group methodology (VI). It is important that those who are to use the system are intimately involved in its development. The results showed, that participation of the end-users during implementation is crucial for its acceptance. The need for a uniform and agreed terminology was obvious to facilitate co-operation and QM. The importance of nurses and physicians using the same terminology for documentation, was paramount.

  • 688.
    af Malmborg, Solith
    Linköping University, Department of Management and Engineering, Malmstens Linköping University.
    Research: ROTHKO: - ett arbete om att lära känna sig själv genom någon annan2017Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    This thesis project examines both inner and outer circumstances of knowledge in an attempt to emphasize the importance of personal reflection. I search for answers on how to communicate feelings through colour and form by studying Mark Rothko and the abstract expressionism. A personal reflection is made parallelly to expand my own understanding of the subject and my own role in relation to it. I also explore painting as amethod of deepening my understanding of Rothko.

    Mark Rothko is both subject of study and tutor as I give myself the task of translating his art into my own design.

    The result offers thoughts and ideas on the significance of the work of hand, the use of colour and the meaning of intention, which I claim are important aspects when aiming for emotional results. However I also reflect upon the fact that the communication remains individual and that it is therefore problematic to confirm success in this matter.

  • 689.
    Af Sandeberg, Margareta
    et al.
    Astrid Lindgrens Childrens Hospital.
    Gustafsson, Karin
    Queen Silvias Childrens Hospital.
    Olsson, Maria
    Queen Silvias Childrens Hospital.
    Renstrom, Maria
    Umea University Hospital.
    Sandgren, Marie
    Östergötlands Läns Landsting.
    Turup, Eva
    Akad Childrens Hospital.
    Mahl, Carina
    Lund Undivers Hospital.
    THE PROCESS IN FORMING NATIONAL RECOMMENDATIONS FOR SOCIAL LIFE AMONG CHILDREN UNDERGOING CANCER TREATMENT in PEDIATRIC BLOOD and CANCER, vol 55, issue 5, pp 980-9812010In: PEDIATRIC BLOOD and CANCER, John Wiley andamp;amp; Sons, Ltd , 2010, Vol. 55, no 5, p. 980-981Conference paper (Refereed)
    Abstract [en]

    n/a

  • 690.
    Af Sandeberg, Margareta
    et al.
    Department of Women's and Children's Health, Karolinska Institutet, Children's and Women's Health, Karolinska University Hospital.
    Wenemark, Marika
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Business support and Development, Department of Health and Care Development.
    Bartholdson, Cecilia
    Department of Women's and Children's Health, Karolinska Institutet, Children's and Women's Health, Karolinska University Hospital.
    Lützén, Kim
    Department of Women's and Children's Health, Karolinska Institutet.
    Pergert, Pernilla
    Department of Women's and Children's Health, Karolinska Institutet, Children's and Women's Health, Karolinska University Hospital.
    To change or not to change - translating and culturally adapting the paediatric version of the Moral Distress Scale-Revised (MDS-R)2017In: BMC Medical Ethics, ISSN 1472-6939, E-ISSN 1472-6939, Vol. 18, no 14, p. 1-9Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Paediatric cancer care poses ethically difficult situations that can lead to value conflicts about what is best for the child, possibly resulting in moral distress. Research on moral distress is lacking in paediatric cancer care in Sweden and most questionnaires are developed in English. The Moral Distress Scale-Revised (MDS-R) is a questionnaire that measures moral distress in specific situations; respondents are asked to indicate both the frequency and the level of disturbance when the situation arises. The aims of this study were to translate and culturally adapt the questionnaire to the context of Swedish paediatric cancer care. In doing so we endeavoured to keep the content in the Swedish version as equivalent to the original as possible but to introduce modifications that improve the functional level and increase respondent satisfaction.

    METHODS: The procedure included linguistic translation and cultural adaptation of MDS-R's paediatric versions for Physicians, Nurses and Other Healthcare Providers to the context of Swedish paediatric cancer care. The process of adjustment included: preparation, translation procedure and respondent validation. The latter included focus group and cognitive interviews with healthcare professionals in paediatric cancer care.

    RESULTS: To achieve a Swedish version with a good functional level and high trustworthiness, some adjustments were made concerning design, language, cultural matters and content. Cognitive interviews revealed problems with stating the level of disturbance hypothetically and items with negations caused even more problems, after having stated that the situation never happens.

    CONCLUSIONS: Translation and cultural adaptation require the involvement of various types of specialist. It is difficult to combine the intention to keep the content as equivalent to the original as possible with the need for modifications that improve the functional level and increase respondent satisfaction. The translated and culturally adapted Swedish MDS-R seems to have equivalent content as well as improved functional level and respondent satisfaction. The adjustments were made to fit paediatric cancer care but it could be argued that the changes are relevant for most areas of paediatric care of seriously ill patients.

  • 691.
    Afazeli, Siamak
    et al.
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Sattari Dabaghi, Alireza
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Dadfar, Hossein
    Linköping University, Department of Management and Engineering, Industrial Marketing and Industrial Economics. Linköping University, The Institute of Technology.
    Dahlgaard, Jens Görn
    Linköping University, Department of Management and Engineering, Quality Technology and Management. Linköping University, The Institute of Technology.
    Assessment of   Enterprise Quality and Export Performance: An Empirical Study on the Pharmaceutical Industry in IRAN2011In: Proceedings QMOD Conference on Quality and Service Science 2011, 14th QMOD Conference 29st-31st August, 2011, San Sebastian, Spain: From LearnAbility & InnovaAbility to SustainAbility / [ed] Carmen Jaca, Ricardo Mateo and Elizabeth Viles Javier Santos, Pamplona, Spain: Servicios de Publicaciones Universidad de Navarra , 2011, p. 55-73Conference paper (Refereed)
    Abstract [en]

    The main purpose of this study is to explore the relationship between export involvement and domestic market performance with focus on pharmaceutical firms. The study covers three research questions including: 1: How to assess the export involvement/performance of the Iranian pharmaceutical companies? 2: How to assess the performance of Iranian pharmaceutical companies in domestic market? 3: How to examine the relationship between export involvement/performance and domestic market performance?

    An intensive literature review and integration of relevant views and models helped us to build our own framework as a conceptual and analytical model. The model consists of EXPERF model, EFQM model, Export performance evaluation, domestic performance evaluation and the relationship between domestic performance and export performance. EFQM model and respective ILL indices was used for measuring domestic performance of the organizations on nine components of leadership, policy and strategy, people, partnership and resources, processes, people results, customer results, society results and key performance results. In order to achieve true representative of Iranian pharmaceutical companies K-mean clustering algorithm has been used to cluster Iranian pharmaceutical companies. EXPERF scale was used to measure export performance of the pharmaceutical companies in Iran on three aspects of financial export performance, strategic export performance and satisfaction with the export venture. Six clusters emerged after running the clustering algorithm in MATLAB software. This software enables us to put the similar companies together. Then centroids of the clusters were chosen to verify the relationship. Then relationship between export involvement (export performance) of pharmaceutical companies and their domestic performance was determined by use of Pearson coefficient.

    Pearson correlation = 0.708 and Sig= 0.026which is less than 0.0 5 then with 95% confidence we can claim that there is a significant relation between export performance of the Centroids and Domestic performance of the centroids of Iranian pharmaceutical companies and considering that the correlation

    coefficient value is positive, it means better export performance will result in better domestic performance. In other words Export performance of the companies has positive direct effect on domestic performance of Iranian pharmaceutical companies. Further studies can be done on clustering of Iranian pharmaceutical companies; effects of export involvement on individual components of EFQM based performance of firms and also verification of effect of export involvement and domestic performance in other business contexts.

  • 692.
    Afghahi, Morteza
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Clocking of high speed CMOS VLSI systems1991Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Two consequences of high level circuit integration may be increasing cost of design and cost of interconnections. Interconnection is expensive in terms of silicon area, speed and power. As far as timing is concerned. schemes of future VLSI systems may not be a simple extension of those used in the existing LSI circuits. This is because the relative importance of clock skew increases as the MOS technology develops and interconnections become slower and slower. Clock skew makes the design of VLSI synchronous circuits ineffective, complicated and failure prone. For a synchronous scheme to be useful in the VLSI environment and enjoy the experiences gained by designers, it must develop to a fast, simple, structured and robust scheme.

    To alleviate the adverse effects of clock skew, technological as well as circuit techniques may be employed. We have proposed a technological solution. It is suggested that a special interconnection metal layer should be introduced into the VLSI process and used for long interconnections. It is shown that by using this technique, the interconnection delay will not be a limiting factor for the performance of synchronous systems.

    We have also considered circuit solutions. To this end, physical causes of clock skew are investigated. It is shown that even for optimized interconnections, traditional modes of clocking results in unacceptable time performance for high speed synchronous systems. Then a new mode of clocking is presented and analysed in detail. By using this mode of clocking, the performance of synchronous systems scales with scaling the minimum feature size of MOS transistors.

    We have developed a synchronous scheme that is structured, simple and general. These factors also make the CMOS systems well suited for design compilation. A circuit technique is proposed that makes the design of synchronous schemes robust. Performance of different asynchronous schemes in VLSI environment is also investigated. It is shown that synchronous schemes outperforms standard asynchronous schemes for a wide range of important applications.

    Finally, in order to test some of the developed rules and principles, a chip has been designed as an example. In this design, a new hardware algorithm is presented for sorting. This algorithm is based on bit-serial data processing. It is shown that this design can operate at a clock frequency determined by the computational module delays and not by the clock skew.

  • 693.
    Afghari, Kamran
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    A Study and Design of High Performance Voltage-Controlled Oscillators in 65nm CMOS Technology2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In recent years, oscillators are considered as inevitable blocks in many electronic systems. They are commonly used in digital circuits to provide clocking and in analog/RF circuits of communication transceivers to support frequency conversion. Nowadays, CMOS technology is the most applicable solution for VLSI and especially for modern integrated circuits used in wireless communications. The main purpose of this project is to design a high performance voltage-controlled oscillator (LC VCO) using 65nm CMOS technology. To meet the state-of-the-art requirements, several circuit solutions have been explored and the design work ended-up with a Quadrature VCO. The circuit operates at center frequency of 2.4 GHz. The phase noise of QVCO obtained by simulation is -140 dBc/Hz at 1MHz offset frequency which is 6 dB less compared to conventional LC VCOs. The power consumption is 3.6mW and the tuning voltage can be swept from 0.2 V to 1.2 V resulting in 2.25 GHz - 2.55 GHz frequency range.

  • 694.
    Afoke, Anthony Okoro
    Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Linköping University, Faculty of Health Sciences.
    Some epidemiological aspects of insulin-dependent diabetes mellitus in Nigeria and Sweden1993Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    In the western world diabetes mellitus is one of the most common severe diseases in childhood, but it is rarely seen in black African populations. However, there are very few epidemiological studies of childhood diabetes in Africa and almost nothing is known of the Nigerian population. One aim of this study was therefore to estimate the prevalence of insulin dependent diabetes (IDDM) in children and adolescents and to characterize their type of diabetes.

    A screening of almost 78,000 school children was performed and beside some already known diabetic patients several new cases were diagnosed. It was found that IDDM is much less common than in Europe but on the other hand more common than in several Asian countries. In addition the prevalence found may be underestimated because of cultural and social factors, health care problems and high mortality in diabetes. Although most patients had a clinical picture of Malnutrition Related Diabetes (MRD) we found in some cases autoantibodies towards islet cells and insulin and furthermore the same HLA-DQ-type-associations as seen to Type 1 diabetes in caucasian diabetics.

    While we saw no seasonal variation of diagnosis of Nigerian IDDM, there is a pronounced such seasonal variation in Sweden. This study has tried to elucidate whether this seasonal variation is related to any differences in manifestation and clinical course. Patients diagnosed during incidence peaks had more often short duration of symptoms before diagnosis,ketonuria at diagnosis, rapid loss of endogenous insulin secretion but increase of insulin antibodies and of glycosylated haemoglobin. They had also more often infections before diagnosis and high serum immunoglobulins (IgG and IgM) up to 9 months after diagnosis. HLA-DR4 was more common in these patients. The results suggest that IDDM in Swedish children is heterogenous.

  • 695.
    Afram, Eliane
    Linköping University, Department of Culture and Communication.
    La percepción de métodos didácticos en la enseñanza del español comolengua extranjera: Análisis cualitativo sobre la percepción de los alumnos de los métodos gramática- traducción,método situacional y método comunicativo2014Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [es]

    Nuestra tesina trata de indagar en cómo piensan los alumnos de bachillerato sobre los métodos didácticos elegidos para aprender una lengua extranjera. El objetivo de esta tesina es investigar tres métodos didácticos; método gramática- traducción, método situacional y método comunicativo, comprobar si los estudiantes los utilizan, y cuál les resulta más útil y por qué. Hemos investigado qué opinan los alumnos con la ayuda del método cualitativo a través de entrevistas cualitativas. Podemos decir que los alumnos utilizan los métodos hasta cierto punto en su enseñanza. Piensan que todos los métodos tienen sus aspectos positivos y negativos. Los aspectos positivos y negativos están repartidos de manera igual entre los métodos didácticos.

  • 696.
    Afram, Eliane
    Linköping University, Department of Culture and Communication.
    Ordinlärning i främmande språk: En forskningsöversikt om effekten av implicita och explicita metoder.2015Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    När man lär sig ett nytt språk så är det ytterst viktigt att kunna ha ett brett och varierat ordförråd. Elever somstuderar engelska som andraspråk eller främmandespråk, eller ett annat modern språk, ställs alltid inför kravet attexpandera sitt ordförråd. Uppsatsen ämnar ge en mer allmän klarhet och bringa förståelse för ordinlärningsprocessenoch dessutom undersöka vilken metod, implicit eller explicit, som leder till ett ökat ordförråd. En systematiskforskningsöversikt genomfördes, och totalt ingick 10 empiriska artiklar som analyserades och kategoriseradessystematiskt. Resultatet visade på en variation gällande studiernas slutsatser på viken metod som är effektivast.Däremot visar resultatet klart och tydligt vikten av att inkludera explicit metod i undervisningen för att effektiviseraordinlärningen speciellt vid läsning.

  • 697.
    Afrell, Maria
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences.
    Att leva med en kropp som värker: samtal med fysioterapeuten2014Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Background and aim: Physiotherapists in primary care meet, assess and treat patients with long-standing benign musculoskeletal pain. As a clinical condition, long-standing pain is common but nonetheless it is quite complex. The aim of this thesis has been, from a bodily existential perspective, to investigate and conceptualise the experience of living with longstanding benign musculoskeletal pain, and from there, to work out a method for conversation and assessment within non-specialised physiotherapy.

    Methods: Our first study was an interview study where we applied a phenomenological approach and investigated the ways individuals suffering from long-standing pain experienced their body and their illness. Four aspects of body experience were described, and based on these aspects, four typologies of attitudes to pain were distinguished. In the second study, we made two group interviews with six physiotherapists about their experiences of using, in their clinical work, questions from the interview guide in study I that had given particularly rich responses. Transcripts were analysed using phenomenography. In the third study, patients’ verbal responses to the key questions, directed to them by physiotherapists in clinical situations, were investigated, and the four aspects of body experience from study I formed the concepts of a deductive analysis. In study IV, finally, the key questions and typologies were tried by a larger group (31), and their experiences and the possible applicability of the method were studied by qualitative content analysis combined with the counting of codes.

    Results: We created four typologies of attitudes to long-standing pain: “Surrendering to one’s fate”, “Accepting by an active process of change”, “Balancing between hope and resignation” and “Rejecting the body”. These typologies, in turn, were based on four aspects of body experience: “The body as an aspect of identity”. “Body reliance”, “Body awareness”, and “Ways of understanding pain”. In study II, by the aid of key questions,  patient and physiotherapist managed to have a conversation on bodily existential matters. The physiotherapist learnt to know the patient as a person, a process appeared to be initiated in the patient, and their relation changed. The patient was willing to talk about her body in pain, and had the words to do this. In study III, the key questions opened ways to reflections on body, existence, and biography. The four aspects of body experience were central to the patients’ descriptions. In study IV, the participating physiotherapists reported by large positive experiences from applying key questions and typologies. The patients reflected, emotions were evoked, and the relation and the communication often improved. The typologies helped in giving a comprehensive perspective of the patient’s problem, and to grasp where in the process of rehabilitation the patient was to be found.

    Conclusions: The method, seven key questions combined with the tentative frame of interpretation of the answers, seemed to be easily applied by interested physiotherapists in non-specialised practice. The application of the method addresses the need of developing the professional role of the physiotherapist. The challenge is to face the whole person, who is her lived body as well as her identity crisis, carried by emotions such as grief and anger. This may inspire the use of the full potential of the physiotherapist’s professional role in the clinical encounter.

    List of papers
    1. Living with a body in pain – between acceptance and denial
    Open this publication in new window or tab >>Living with a body in pain – between acceptance and denial
    2007 (English)In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 21, no 3, p. 291-296Article in journal (Refereed) Published
    Abstract [en]

    The aetiology of nonspecific musculoskeletal pain is considered to be multi-factorial. Long-standing pain not only has a negative impact on the individual's general health but also changes the individual's experience of him/her self and his/her world. The aim of this study was to describe how individuals with long-standing musculoskeletal pain, in a bodily existential perspective, relate to their aching body. Semi-structured interviews with 20 patients were analysed using mainly a phenomenological-hermeneutic method. From the analysis, four main categories reflect the meaning contents of the interviews: the body as an aspect of identity; body reliance; body awareness; ways of understanding pain. From these categories, four distinct typologies were inferred: surrendering to ones fate; accepting by an active process of change; balancing between hope and resignation; rejecting the body. The result indicates that patients with long-standing pain are to be found along a spectrum from accepting to rejecting the aching body. Body awareness and body reliance seem to have importance in the process of acceptance of the body as well as life situation as a whole, which we regard as interesting hypotheses for further inquiry.

    Place, publisher, year, edition, pages
    John Wiley & Sons, 2007
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-106745 (URN)10.1111/j.1471-6712.2007.00475.x (DOI)17727540 (PubMedID)
    Available from: 2014-05-21 Created: 2014-05-21 Last updated: 2017-12-05Bibliographically approved
    2. We got the whole story all at once: physiotherapists use of key questions when meeting patients with long-standing pain
    Open this publication in new window or tab >>We got the whole story all at once: physiotherapists use of key questions when meeting patients with long-standing pain
    2010 (English)In: SCANDINAVIAN JOURNAL OF CARING SCIENCES, ISSN 0283-9318, Vol. 24, no 2, p. 281-289Article in journal (Refereed) Published
    Abstract [en]

    Long-standing musculoskeletal pain has many dimensions. Physiotherapy lacks a tested method of dialogue with which physiotherapists and patients can together explore pain in all its complexity. The present aim was to find out how physiotherapists experienced the influence of systematically prepared key questioning on their relation to, and understanding of, patients with long-standing pain. A group of six physiotherapists with long experience of pain rehabilitation used such questions in their encounters with their patients. Two periods of work with the questions were followed by discussions in which the physiotherapists shared their experience in a joint focus group. Verbatim transcripts of the discussions constitute the data of the study. A phenomenographic method was used for the analysis. The responses to the key questions gave the physiotherapists an insight into the patient as a person. The questions started a process of change in the patient, and changed the physiotherapists relation to her or him. The patient expressed feelings and experience, and this also seemed to encourage a change in chosen coping strategies. This new content of the interaction challenged the physiotherapists role, thus raising questions about her professional mandate.

    Place, publisher, year, edition, pages
    Blackwell Publishing Ltd, 2010
    Keywords
    qualitative method, phenomenography, dialogue method, key questions, biopsychosocial, pain management, physiotherapy, professional mandate
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-56678 (URN)10.1111/j.1471-6712.2009.00718.x (DOI)000277713500011 ()
    Available from: 2010-05-31 Created: 2010-05-31 Last updated: 2014-05-21
    3. Telling about long-lasting pain – the role of key questions in physiotherapy encounters
    Open this publication in new window or tab >>Telling about long-lasting pain – the role of key questions in physiotherapy encounters
    2014 (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Aim: For a physiotherapist in primary care wishing to meet her/his patient in the entirety of possible causes of long-lasting pain, the ability to perceive its nuances and context is indispensable.

    The aim was to investigate the verbal responses of patients with long-lasting pain to key questions addressing their biography, identity and lived body.

    Methodology: Three Swedish physiotherapists asked eight patients with long-lasting pain seven questions regarding body experience at the introductory and concluding, tape-recorded, treatment sessions. A deductive, qualitative analysis was made through four concepts naming aspects of body experience: body reliance, body awareness, models for explaining pain and the body’s integration in the identity.

    Major findings: The key questions opened ways to bodily-existential reflections. The aspects of body experience were central to the patients’ descriptions. Appreciable differences emerged between the patients in how they described the experience of living with pain, and in some cases differences were seen between the conversations of the first and the last treatment session with the same patient.

    Conclusions: The questions addressed crucial issues of living with pain and seem to have a potential to capture changes in body experience. Physiotherapists may recognize their patients’ biographical disruptions, reconstruction and adapt their treatment accordingly.

    Keywords
    Pain management, Clinical dialogue, Physiotherapy, Bodily existential perspective, Body awareness, Body reliance, Key questions, Deductive qualitative analysis
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-106746 (URN)
    Available from: 2014-05-21 Created: 2014-05-21 Last updated: 2014-05-21Bibliographically approved
    4. Improving the interaction between the physiotherapist and the patient with long-lasting pain
    Open this publication in new window or tab >>Improving the interaction between the physiotherapist and the patient with long-lasting pain
    2014 (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Purpose: To investigate whether it would be possible to improve the understanding and communication between physiotherapists and patients with long-lasting pain by, in a systematic way, approaching their condition from a bodily existential perspective.

    Method: 31 physiotherapists answered written open questions about what happened when they in 90 encounters used key questions about living with pain together with a tentative frame for interpreting the answers - typologies of approaches to living with long-lasting pain. In the analysis, we combined qualitative content analysis with the counting of the numbers of codes.

    Results: According to the physiotherapists, patients were positive to answering the key questions, which also evoked emotional responses and reflection. The relation between the physiotherapists and their patients improved. The typologies helped the physiotherapists understand their patients better, as well as in assessing the patients’ problems and choosing treatment. In all, positive experience clearly dominated. Conclusion: When used by physiotherapists with an interest in patients with longlasting pain, the key questions and typologies seem to enrich the clinical interaction in many cases. To try the generalisability of our findings, we regard it an interesting possibility to conduct a larger, quantitative questionnaire study based on the experiences and results of the present one.

    Keywords
    Qualitative method, pain management, pain assessment, clinical dialogue, communication, bodily existential, physiotherapy
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-106747 (URN)
    Available from: 2014-05-21 Created: 2014-05-21 Last updated: 2014-05-21Bibliographically approved
  • 698.
    Afrell, Maria
    et al.
    Unit of Rehabilitation, Kalmer County Council, Västervik.
    Biguet, Gabriele
    Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm.
    Rudebeck, Carl Edvard
    Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Stockholm.
    Living with a body in pain – between acceptance and denial2007In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 21, no 3, p. 291-296Article in journal (Refereed)
    Abstract [en]

    The aetiology of nonspecific musculoskeletal pain is considered to be multi-factorial. Long-standing pain not only has a negative impact on the individual's general health but also changes the individual's experience of him/her self and his/her world. The aim of this study was to describe how individuals with long-standing musculoskeletal pain, in a bodily existential perspective, relate to their aching body. Semi-structured interviews with 20 patients were analysed using mainly a phenomenological-hermeneutic method. From the analysis, four main categories reflect the meaning contents of the interviews: the body as an aspect of identity; body reliance; body awareness; ways of understanding pain. From these categories, four distinct typologies were inferred: surrendering to ones fate; accepting by an active process of change; balancing between hope and resignation; rejecting the body. The result indicates that patients with long-standing pain are to be found along a spectrum from accepting to rejecting the aching body. Body awareness and body reliance seem to have importance in the process of acceptance of the body as well as life situation as a whole, which we regard as interesting hypotheses for further inquiry.

  • 699.
    Afrell, Maria
    et al.
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences. Samrehab, Kalmar County Council, Västervik Hospital, Sweden.
    Brudin, Lars
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Department of Clinical Physiology, Kalmar County Hospital, Kalmar, Sweden.
    Rudebeck, Carl Edvard
    Department of Community Medicine, University of Tromsö, Norway / The Research Unit, Kalmar County Council, Sweden.
    Improving the interaction between the physiotherapist and the patient with long-lasting pain2014Manuscript (preprint) (Other academic)
    Abstract [en]

    Purpose: To investigate whether it would be possible to improve the understanding and communication between physiotherapists and patients with long-lasting pain by, in a systematic way, approaching their condition from a bodily existential perspective.

    Method: 31 physiotherapists answered written open questions about what happened when they in 90 encounters used key questions about living with pain together with a tentative frame for interpreting the answers - typologies of approaches to living with long-lasting pain. In the analysis, we combined qualitative content analysis with the counting of the numbers of codes.

    Results: According to the physiotherapists, patients were positive to answering the key questions, which also evoked emotional responses and reflection. The relation between the physiotherapists and their patients improved. The typologies helped the physiotherapists understand their patients better, as well as in assessing the patients’ problems and choosing treatment. In all, positive experience clearly dominated. Conclusion: When used by physiotherapists with an interest in patients with longlasting pain, the key questions and typologies seem to enrich the clinical interaction in many cases. To try the generalisability of our findings, we regard it an interesting possibility to conduct a larger, quantitative questionnaire study based on the experiences and results of the present one.

  • 700.
    Afrell, Maria
    et al.
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences. Samrehab, Västerviks sjukhus, Kalmar County Council, Sweden.
    Rudebeck, Carl Edvard
    Department of Community Medicine, Tromsö University, Tromsö, Norway / The Research Unit, Kalmar County Council, Sweden.
    Telling about long-lasting pain – the role of key questions in physiotherapy encounters2014Manuscript (preprint) (Other academic)
    Abstract [en]

    Aim: For a physiotherapist in primary care wishing to meet her/his patient in the entirety of possible causes of long-lasting pain, the ability to perceive its nuances and context is indispensable.

    The aim was to investigate the verbal responses of patients with long-lasting pain to key questions addressing their biography, identity and lived body.

    Methodology: Three Swedish physiotherapists asked eight patients with long-lasting pain seven questions regarding body experience at the introductory and concluding, tape-recorded, treatment sessions. A deductive, qualitative analysis was made through four concepts naming aspects of body experience: body reliance, body awareness, models for explaining pain and the body’s integration in the identity.

    Major findings: The key questions opened ways to bodily-existential reflections. The aspects of body experience were central to the patients’ descriptions. Appreciable differences emerged between the patients in how they described the experience of living with pain, and in some cases differences were seen between the conversations of the first and the last treatment session with the same patient.

    Conclusions: The questions addressed crucial issues of living with pain and seem to have a potential to capture changes in body experience. Physiotherapists may recognize their patients’ biographical disruptions, reconstruction and adapt their treatment accordingly.

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