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  • 951.
    Ahlman, Per-Arne
    Linköping University, Department of Mechanical Engineering, Machine Design.
    Smörjning Av Lager2009Independent thesis Basic level (university diploma), 15 credits / 22,5 HE creditsStudent thesis
    Abstract [en]

    The work thesis was performed at Assalub a company which is situated in Åtvidaberg. The company works with developing, manufacturing and marketing equipment for handling of lubricants for light and heavier industry. The work thesis it is based on a inquiry Assalub got from MacGregor which is a company within cargo solution, from port to offshore system.

    For unloading grain and other material from the ship cargo it is used combined inlet feeder and screw conveyor, there the inlet feeder is drilling down through the cargo and feed the screw conveyer with material to further destination. At the bottom of the screw conveyer and the inlet feeder there is a bearing that keep the parts together. However the lubrication of the bearing must be made manually. Until now the bearing was lubricated manually through a grease nipple from the bottom of the drill once a day.

     

    The purpose of the thesis was the construction of a lubricating system namely a pump with a grease container which should be placed inside the space of the screw conveyer, so the bearing will be continually lubricated and able to work several days without any stoppage.

    After receiving drawings and operating data for the screw conveyer, the details for the construction was designed in CAD system Solid Edge. The solid mechanics calculations on the weakest point on the construction was made by hand and afterwards the drawings for respectively details was made.

    The construction was completed, but because of the time limit for this work thesis, the manufacturing, mounting and testing were not included in these weeks. The grease containers capacity is approximately seventy-two hours, although desirable should be up to seven days. According to the solid mechanics calculations, the construction should have no problem to resist the stresses it would be exposed to.

    Since this is a prototype there is probably some adjustments and improvements to do, but the estimating is that the system should work properly as it is now.

  • 952.
    Ahlmann, Jacob
    et al.
    Linköping University, Department of Computer and Information Science.
    Bergström, Lovisa
    Linköping University, Department of Computer and Information Science.
    Erholm, Anton
    Linköping University, Department of Computer and Information Science.
    Freyschuss, Erik
    Linköping University, Department of Computer and Information Science.
    Hartikainen, Johan
    Linköping University, Department of Computer and Information Science.
    Holm Eriksson, Liv
    Linköping University, Department of Computer and Information Science.
    Jacobson, Simon
    Linköping University, Department of Computer and Information Science.
    Oskarsson, Fredrik
    Linköping University, Department of Computer and Information Science.
    Utveckling av applikationen Hokus Bokus: En praktisk tillämpning av agil programutvecklingsmetodik2015Independent thesis Basic level (degree of Bachelor), 12 credits / 18 HE creditsStudent thesis
    Abstract [sv]

    Rapporten beskriver utvecklandet av applikationen Hokus Bokus, en plattform för försäljning av begagnad studentlitteratur på Linköpings Tekniska Högskola. Det som adresseras är dels utvecklingsprocessen men även den tekniska aspekten. För att förbereda Hokus Bokus för marknaden har en marknadsplan gjorts som inkluderar nulägesanalys, konkurrentanalys och identifiering av kundsegment. Teamet har arbetat enligt arbetsmetoden scrum och i rapporten görs en analys av hur detta implementerats. Läsaren får även ta del av den resulterande applikationens utformning och funktionalitet. En beskrivning av systemet och en utvärdering i form av användartester genomfördes. Slutsatsen som dras av arbetet är att en e-handel kan öka försäljningen och minska priset på kurslitteratur genom att samla marknaden på en enklare, gemensam och mer effektiv plattform som Hokus Bokus. Rapporten tar även upp etiska aspekter såsom hantering av användardata och kommunikationskryptering. Slutligen diskuteras applikationens styrkor, svagheter samt framtida möjligheter.

  • 953.
    Ahlmén, M
    et al.
    SU.
    Nordenskiöld, U
    SU.
    Archenholtz, B
    SU.
    Thyberg, Ingrid
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Rheumatology. Östergötlands Läns Landsting, Centre for Medicine, Department of Rheumatology in Östergötland.
    Rönnqvist, R
    KI.
    Lindén, L
    KI.
    Andersson, A-K
    Mannerkorpi, K
    Rheumatology outcomes: The patient's perspective. A multicentre focus group interview study of Swedish rheumatoid arthritis patients2005In: Rheumatology, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 44, no 1, p. 105-110Article in journal (Refereed)
    Abstract [en]

    Objectives. Patients with rheumatoid arthritis (RA) and clinicians have different views about benefits from treatments. More knowledge is needed about how patients assess outcomes in order to update current measurements. Methods. Focus group interviews were performed at four Swedish rheumatology clinics. A total of 25 patients with RA were included, representing a wide range of ages and disease duration. Predetermined topics relating to important outcomes from and satisfaction/dissatisfaction with RA treatments were discussed. Results. The participants' initial outcome assessments included physical and psychosocial items, which comprised overall treatment goals such as impairment in social roles, fatigue, daily activities and self-confidence. The identified themes were 'Normal life', 'Physical capacity', 'Independence' and 'Well-being'. Satisfaction with treatment was associated with the quality of communication between staff and the patient. The participants assumed this as a prerequisite for a treatment to work. Patients wanted to be accepted as experts on their own bodies, and expected all clinicians to be experts on RA. This made it possible for patients to 'take charge' of their life situation. Good resources for and access to rheumatology care were desired. Conclusions. Suggesting a holistic approach to rheumatology care, the study results indicate that the illness and outcomes have to be evaluated within an individual RA patient's total life situation, described in the identified themes: 'Normal life', 'Physical capacity', 'Independence' and 'Well-being'. Development and validation of measurements covering these issues is suggested. More research is needed about communication and how patients experience their roles in the rheumatology clinic.

  • 954.
    Ahlner, Alexandra
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Improved Methods for Characterization of Protein Dynamics by NMR spectroscopy and Studies of the EphB2 Kinase Domain2015Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Proteins are essential for all known forms of life and in many lethal diseases protein failure is the cause of the disease. To understand proteins and the processes they are involved in, it is valuable to know their structures as well as their dynamics and interactions. The structures may not be directly inspected because proteins are too small to be visible in a light microscope, which is why indirect methods such as nuclear magnetic resonance (NMR) spectroscopy have to be utilized. This method provides atomic information about the protein and, in contrast to other methods with similar resolution, the measurements are performed in solution resulting in more physiological conditions, enabling analysis of dynamics. Important dynamical processes are the ones on the millisecond timeframe, which may contribute to interactions of proteins and their catalysis of chemical reactions, both of significant value for the function of the proteins.

    To better understand proteins, not only do we need to study them, but also develop the methods we are using. This thesis presents four papers about improved NMR techniques as well as a fifth where the kinase domain of ephrinB receptor 2 (EphB2) has been studied regarding the importance of millisecond dynamics and interactions for the activation process. The first paper presents the software COMPASS, which combines statistics and the calculation power of a computer with the flexibility and experience of the user to facilitate and speed up the process of assigning NMR signals to the atoms in the protein. The computer program PINT has been developed for easier and faster evaluation of NMR experiments, such as those that evaluate protein dynamics. It is especially helpful for NMR signals that are difficult to distinguish, so called overlapped peaks, and the soft- ware also converts the detected signals to the indirectly measured physical quantities, such as relaxation rate constants, principal for dynamics. Next are two new versions of the Carr-Purcell-Maiboom-Gill (CPMG) dispersion pulse sequences, designed to measure millisecond dynamics in a way so that the signals are more separated than in standard experiments, to reduce problems with overlaps. To speed up the collection time of the data set, a subset is collected and the entire data set is then reconstructed, by multi-dimensional decomposition co-processing. Described in the thesis is also a way to produce suitably labeled proteins, to detect millisecond dynamics at Cα positions in proteins, using the CPMG dispersion relaxation experiment at lower protein concentrations. Lastly, the kinase domain of EphB2 is shown to be more dynamic on the millisecond time scale as well as more prone to interact with itself in the active form than in the inactive one. This is important for the receptor function of the protein, when and how it mediates signals.

    To conclude, this work has extended the possibilities to study protein dynamics by NMR spectroscopy and contributed to increased understanding of the activation process of EphB2 and its signaling mechanism. 

    List of papers
    1. Fast and Accurate Resonance Assignment of Small-to-Large Proteins by Combining Automated and Manual Approaches
    Open this publication in new window or tab >>Fast and Accurate Resonance Assignment of Small-to-Large Proteins by Combining Automated and Manual Approaches
    Show others...
    2015 (English)In: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 11, no 1, p. e1004022-Article in journal (Refereed) Published
    Abstract [en]

    The process of resonance assignment is fundamental to most NMR studies of protein structure and dynamics. Unfortunately, the manual assignment of residues is tedious and time-consuming, and can represent a significant bottleneck for further characterization. Furthermore, while automated approaches have been developed, they are often limited in their accuracy, particularly for larger proteins. Here, we address this by introducing the software COMPASS, which, by combining automated resonance assignment with manual intervention, is able to achieve accuracy approaching that from manual assignments at greatly accelerated speeds. Moreover, by including the option to compensate for isotope shift effects in deuterated proteins, COMPASS is far more accurate for larger proteins than existing automated methods. COMPASS is an open-source project licensed under GNU General Public License and is available for download from http://www.liu.se/forskning/foass/tidigare-foass/patrik-lundstrom/software?l=en. Source code and binaries for Linux, Mac OS X and Microsoft Windows are available.

    Place, publisher, year, edition, pages
    Public Library of Science, 2015
    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:liu:diva-115010 (URN)10.1371/journal.pcbi.1004022 (DOI)000349309400013 ()25569628 (PubMedID)
    Note

    Funding Agencies|Swedish Research Council [Dnr. 2012-5136]

    Available from: 2015-03-09 Created: 2015-03-06 Last updated: 2017-12-04
    2. PINT: a software for integration of peak volumes and extraction of relaxation rates
    Open this publication in new window or tab >>PINT: a software for integration of peak volumes and extraction of relaxation rates
    2013 (English)In: Journal of Biomolecular NMR, ISSN 0925-2738, E-ISSN 1573-5001, Vol. 56, no 3, p. 191-202Article in journal (Refereed) Published
    Abstract [en]

    We present the software Peak INTegration (PINT), designed to perform integration of peaks in NMR spectra. The program is very simple to run, yet powerful enough to handle complicated spectra. Peaks are integrated by fitting predefined line shapes to experimental data and the fitting can be customized to deal with, for instance, heavily overlapped peaks. The results can be inspected visually, which facilitates systematic optimization of the line shape fitting. Finally, integrated peak volumes can be used to extract parameters such as relaxation rates and information about low populated states. The utility of PINT is demonstrated by applications to the 59 residue SH3 domain of the yeast protein Abp1p and the 289 residue kinase domain of murine EphB2.

    Place, publisher, year, edition, pages
    Springer Verlag (Germany), 2013
    Keywords
    Peak integration, Overlapped peaks, Relaxation rates, Protein dynamics
    National Category
    Cell and Molecular Biology
    Identifiers
    urn:nbn:se:liu:diva-95951 (URN)10.1007/s10858-013-9737-7 (DOI)000321544600001 ()
    Note

    Funding Agencies|Swedish Research Council||

    Available from: 2013-08-19 Created: 2013-08-12 Last updated: 2018-01-11Bibliographically approved
    3. Measurement of Protein Backbone 13CO and 15N Relaxation Dispersion at High Resolution
    Open this publication in new window or tab >>Measurement of Protein Backbone 13CO and 15N Relaxation Dispersion at High Resolution
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Three-dimensional pulse sequences for the measurement of Carr-Purcell-Meiboom-Gill relaxation dispersions and new methods for co-processing non-uniformly sampled data are presented. The new methodology was validated for the disordered protein IgA and for an SH3 domain from Abp1p in exchange between its free form and bound to a peptide from the protein Ark1p. We show that the results are similar to ones obtained using traditional experiments and that accurate excited state chemical shifts can be determined. Furthermore, we show that jackknife analysis of down sampled spectra yields robust estimates of peak intensities errors, eliminating the need for recording duplicate data points. The methodology should be useful for characterization of millisecond dynamics in small to medium-sized proteins with poorly dispersed spectra.

    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:liu:diva-117070 (URN)
    Available from: 2015-04-15 Created: 2015-04-15 Last updated: 2015-04-15Bibliographically approved
    4. Fractional enrichment of proteins using [2-13C]-glycerol as the carbon source facilitates measurement of excited state 13Cα chemical shifts with improved sensitivity
    Open this publication in new window or tab >>Fractional enrichment of proteins using [2-13C]-glycerol as the carbon source facilitates measurement of excited state 13Cα chemical shifts with improved sensitivity
    Show others...
    2015 (English)In: Journal of Biomolecular NMR, ISSN 0925-2738, E-ISSN 1573-5001, Vol. 62, no 3, p. 341-351Article in journal (Refereed) Published
    Abstract [en]

    A selective isotope labeling scheme based on the utilization of [2-13C]-glycerol as the carbon source during protein overexpression has been evaluated for the measurement of excited state 13Cα chemical shifts using Carr–Purcell–Meiboom–Gill (CPMG) relaxation dispersion (RD) experiments. As expected, the fractional incorporation of label at the Cα positions is increased two-fold relative to labeling schemes based on [2-13C]-glucose, effectively doubling the sensitivity of NMR experiments. Applications to a binding reaction involving an SH3 domain from the protein Abp1p and a peptide from the protein Ark1p establish that accurate excited state 13Cα chemical shifts can be obtained from RD experiments, with errors on the order of 0.06 ppm for exchange rates ranging from 100 to 1000 s−1, despite the small fraction of 13Cα–13Cβ spin-pairs that are present for many residue types. The labeling approach described here should thus be attractive for studies of exchanging systems using 13Cα spin probes.

    Place, publisher, year, edition, pages
    Springer Netherlands, 2015
    Keywords
    CPMG, 13Cα labeling, [2-13C]-Glycerol, Excited states
    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:liu:diva-117073 (URN)10.1007/s10858-015-9948-1 (DOI)000357489200010 ()
    Note

    At the time for thesis presentation publication was in status: Manuscript

    At the time for thesis presentation name of publication was: Fractional enrichment using [2-13C]-glycerol as the carbon source facilitates measurements of excited state 13Cα chemical shifts with improved sensitivity

    Available from: 2015-04-15 Created: 2015-04-15 Last updated: 2017-12-04Bibliographically approved
    5. Conformational Dynamics and Multimerization of Active Forms of the EphrinB Receptor 2 Kinase Domain
    Open this publication in new window or tab >>Conformational Dynamics and Multimerization of Active Forms of the EphrinB Receptor 2 Kinase Domain
    Show others...
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Active and autoinhibited forms of the ephrinB receptor 2 (EphB2) kinase domain have been studied using NMR spectroscopy. The project was initiated because of the finding that the crystal structures of active forms of the kinase domain and previous NMR studies suggested that a change in inter-lobe flexibility and the sampling of catalytically competent excited states conformations are responsible for activity. Using Carr-Purcell-Meiboom-Gill relaxation dispersion experiments, we have measured millisecond dynamics to identify such states. We have also performed concentration dependent relaxation experiments and analytical ultracentrifugation experiments that report on the effective protein size to look for possible differences in self-association for active and autoinhibited forms of the EphB2 kinase domain. We show that the active but not autoinhibited forms exchange between a ground state and an excited state at a rate of 1900 s-1. Similar results were found for the S677/680A mutant of the protein. The nature and importance of the excited state is still unknown. Our most important finding is that active forms of the kinase domain self-associate in a concentration dependent manner and form tetramers and possibly larger oligomers. Multimerization of the kinase domain may enable the assembly of complexes of downstream proteins and could be important for Eph signaling.

    Keywords
    Kinase activation | Eph receptors | chemical exchange | nmr spectroscopy | protein dynamics | self-association
    National Category
    Chemical Sciences
    Identifiers
    urn:nbn:se:liu:diva-117071 (URN)
    Available from: 2015-04-15 Created: 2015-04-15 Last updated: 2015-04-15Bibliographically approved
  • 955.
    Ahlner, Alexandra
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Andresen, Cecilia
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Khan, Shahid N.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Kay, Lewis E.
    Departments of Medical Genetics, Biochemistry and Chemistry, The University of Toronto, Canada.
    Lundström, Patrik
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Fractional enrichment of proteins using [2-13C]-glycerol as the carbon source facilitates measurement of excited state 13Cα chemical shifts with improved sensitivity2015In: Journal of Biomolecular NMR, ISSN 0925-2738, E-ISSN 1573-5001, Vol. 62, no 3, p. 341-351Article in journal (Refereed)
    Abstract [en]

    A selective isotope labeling scheme based on the utilization of [2-13C]-glycerol as the carbon source during protein overexpression has been evaluated for the measurement of excited state 13Cα chemical shifts using Carr–Purcell–Meiboom–Gill (CPMG) relaxation dispersion (RD) experiments. As expected, the fractional incorporation of label at the Cα positions is increased two-fold relative to labeling schemes based on [2-13C]-glucose, effectively doubling the sensitivity of NMR experiments. Applications to a binding reaction involving an SH3 domain from the protein Abp1p and a peptide from the protein Ark1p establish that accurate excited state 13Cα chemical shifts can be obtained from RD experiments, with errors on the order of 0.06 ppm for exchange rates ranging from 100 to 1000 s−1, despite the small fraction of 13Cα–13Cβ spin-pairs that are present for many residue types. The labeling approach described here should thus be attractive for studies of exchanging systems using 13Cα spin probes.

  • 956.
    Ahlner, Alexandra
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Biotechnology. Linköping University, The Institute of Technology.
    Carlsson, Mats
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Biotechnology. Linköping University, The Institute of Technology.
    Jonsson, Bengt-Harald
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Biotechnology. Linköping University, The Institute of Technology.
    Lundström, Patrik
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Biotechnology. Linköping University, The Institute of Technology.
    PINT: a software for integration of peak volumes and extraction of relaxation rates2013In: Journal of Biomolecular NMR, ISSN 0925-2738, E-ISSN 1573-5001, Vol. 56, no 3, p. 191-202Article in journal (Refereed)
    Abstract [en]

    We present the software Peak INTegration (PINT), designed to perform integration of peaks in NMR spectra. The program is very simple to run, yet powerful enough to handle complicated spectra. Peaks are integrated by fitting predefined line shapes to experimental data and the fitting can be customized to deal with, for instance, heavily overlapped peaks. The results can be inspected visually, which facilitates systematic optimization of the line shape fitting. Finally, integrated peak volumes can be used to extract parameters such as relaxation rates and information about low populated states. The utility of PINT is demonstrated by applications to the 59 residue SH3 domain of the yeast protein Abp1p and the 289 residue kinase domain of murine EphB2.

  • 957.
    Ahlner, Alexandra
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Khan, Shahid N.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Forman-Kay, Julie D.
    Molecular Structure and Function Program, Hospital for Sick Children; Department and Biochemistry, University of Toronto, Canada.
    Sicheri, Frank
    cDepartment and Biochemistry, University of Toronto; Department of Molecular Genetics, University of Toronto; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada.
    Lundström, Patrik
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Conformational Dynamics and Multimerization of Active Forms of the EphrinB Receptor 2 Kinase DomainManuscript (preprint) (Other academic)
    Abstract [en]

    Active and autoinhibited forms of the ephrinB receptor 2 (EphB2) kinase domain have been studied using NMR spectroscopy. The project was initiated because of the finding that the crystal structures of active forms of the kinase domain and previous NMR studies suggested that a change in inter-lobe flexibility and the sampling of catalytically competent excited states conformations are responsible for activity. Using Carr-Purcell-Meiboom-Gill relaxation dispersion experiments, we have measured millisecond dynamics to identify such states. We have also performed concentration dependent relaxation experiments and analytical ultracentrifugation experiments that report on the effective protein size to look for possible differences in self-association for active and autoinhibited forms of the EphB2 kinase domain. We show that the active but not autoinhibited forms exchange between a ground state and an excited state at a rate of 1900 s-1. Similar results were found for the S677/680A mutant of the protein. The nature and importance of the excited state is still unknown. Our most important finding is that active forms of the kinase domain self-associate in a concentration dependent manner and form tetramers and possibly larger oligomers. Multimerization of the kinase domain may enable the assembly of complexes of downstream proteins and could be important for Eph signaling.

  • 958.
    Ahlner, Alexandra
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Mayzel, Maxim
    The Swedish NMR Centre, University of Gothenburg, Sweden.
    Lundström, Patrik
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, The Institute of Technology.
    Orekhov, Vladislav Y.
    The Swedish NMR Centre, University of Gothenburg, Sweden.
    Measurement of Protein Backbone 13CO and 15N Relaxation Dispersion at High ResolutionManuscript (preprint) (Other academic)
    Abstract [en]

    Three-dimensional pulse sequences for the measurement of Carr-Purcell-Meiboom-Gill relaxation dispersions and new methods for co-processing non-uniformly sampled data are presented. The new methodology was validated for the disordered protein IgA and for an SH3 domain from Abp1p in exchange between its free form and bound to a peptide from the protein Ark1p. We show that the results are similar to ones obtained using traditional experiments and that accurate excited state chemical shifts can be determined. Furthermore, we show that jackknife analysis of down sampled spectra yields robust estimates of peak intensities errors, eliminating the need for recording duplicate data points. The methodology should be useful for characterization of millisecond dynamics in small to medium-sized proteins with poorly dispersed spectra.

  • 959.
    Ahlner, Ida
    et al.
    Linköping University, Department for Studies of Social Change and Culture.
    Thisell, Felicia
    Linköping University, Department for Studies of Social Change and Culture.
    Kultur i förändring: En vidgad syn på kultursektorn och dess roll för samhället2008Independent thesis Advanced level (degree of Magister), 20 points / 30 hpStudent thesis
    Abstract [en]

    How can you do a right measurement of culture as well as with other social sectors and with what can culture contribute when it comes to a town´s development? We found out that in Linköping the regional federation Ostsam recently (2005) started mapping the region's creative centers in order to look into the spreading of the culture in the county, and then use the uniqueness of the culture as an advantage in society- planning contexts. The reason was that both municipal - and State directions detected that the culture has a broader importance when it comes to building up society and infrastructure than earlier considered. This is called Cultural planning and is the foundation- method that Östsam used when working with their new projekt The creative sector. The outcome of the Östsam study resulted in an exciting study basis to work further on with and to examine through own demarcations and directions.

    This research manages the matter of the creative sector as an extension to the cultural sector. Our aim with this report is to find out the concept of the creative sector, what it stands for, and also to look into how the creative sector runs in practice.

  • 960.
    Ahlner, Johan
    et al.
    Linköping University, Department of Medicine and Health Sciences, Clinical Pharmacology . Linköping University, Faculty of Health Sciences.
    Aamo, T. O.
    Trondheims University.
    THERAPEUTIC DRUG MONITORING AND CLINICAL TOXICOLOGY2009In: in BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, vol 105, 2009, Vol. 105, p. 16-16Conference paper (Refereed)
    Abstract [en]

    n/a

  • 961.
    Ahlner, Johan
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Clinical Pharmacology.
    Druid, H
    Holmgren, P
    Genotyping avseende metabolism av läkemedel och droger - betydelse i forensiska sammanhang.1999In: Nordisk Rettsmedisin, ISSN 0809-1498, Vol. 5, p. 47-48Article in journal (Other (popular science, discussion, etc.))
  • 962.
    Ahlner, Johan
    et al.
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Swedish National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden.
    Holmgren, Anita
    Swedish National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden.
    Jones, A Wayne
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Swedish National Board Forens Med, Department Forens Genet and Forens Toxicol, Linkoping, Sweden.
    Demographics and post-mortem toxicology findings in deaths among people arrested multiple times for use of illicit drugs and/or impaired driving2016In: Forensic Science International, ISSN 0379-0738, E-ISSN 1872-6283, Vol. 265, p. 138-143Article in journal (Refereed)
    Abstract [en]

    Background: Multiple arrests for use of illicit drugs and/or impaired driving strongly suggests the existence of a personality disorder and/or a substance abuse problem. Methods: This retrospective study (1993-2010) used a national forensic toxicology database (TOXBASE), and we identified 3943 individuals with two or more arrests for use of illicit drugs and/or impaired driving. These individuals had subsequently died from a fatal drug poisoning or some other cause of death, such as trauma. Results: Of the 3943 repeat offenders 1807 (46%) died from a fatal drug overdose and 2136 (54%) died from other causes (p amp;lt; 0.001). The repeat offenders were predominantly male (90% vs 10%) and mean age of drug poisoning deaths was 5 y younger (mean 35 y) than other causes of death (mean 40 y). Significantly more repeat offenders (46%) died from drug overdose compared with all other forensic autopsies (14%) (p amp;lt; 0.001). Four or more drugs were identified in femoral blood in 44% of deaths from poisoning (drug overdose) compared with 18% of deaths by other causes (p amp;lt; 0.001). The manner of death was considered accidental in 54% of deaths among repeat offenders compared with 28% for other suspicious deaths (p amp;lt; 0.001). The psychoactive substances most commonly identified in autopsy blood from repeat offenders were ethanol, morphine (from heroin), diazepam, amphetamines, cannabis, and various opioids. Conclusions: This study shows that people arrested multiple times for use of illicit drugs and/or impaired driving are more likely to die by accidentally overdosing with drugs. Lives might be saved if repeat offenders were sentenced to treatment and rehabilitation for their drug abuse problem instead of conventional penalties for drug-related crimes. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

  • 963.
    Ahlner, Johan
    et al.
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
    Holmgren, Anita
    National Board for Forensic Medicine, Linkoping, Sweden .
    Jones, A Wayne
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
    Prevalence of alcohol and other drugs and the concentrations in blood of drivers killed in road traffic crashes in Sweden2014In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 42, no 2, p. 177-183Article in journal (Refereed)
    Abstract [en]

    Background: Drunk or drug-impaired drivers represent a major public health and societal problem worldwide. Because over 95% of drivers killed on the roads in Sweden are autopsied, reliable information is available about the use of alcohol and/or other drug before the crash. Methods: This retrospective 4-year study (2008-2011) used a forensic toxicology database (TOXBASE) to evaluate the concentrations of alcohol and other drugs in blood samples from drivers killed in road-traffic crashes. Results: The mean age of all victims (N = 895) was 48 +/- 20 years, and the majority were male (86%). In 504 drivers (56%), the results of toxicological analysis were negative and these victims were older; mean age (+/- SD) 47 +/- 20 years, than alcohol positive cases (35 +/- 14 years) and illicit drug users (34 +/- 15 years). In 21% of fatalities, blood-alcohol concentration (BAC) was above the statutory limit for driving (0.2 g/L), although the median BAC was appreciably higher (1.72 g/L). Illicit drugs (mainly amphetamine and cannabis) were identified in similar to 7% of victims, either alone (2.5%), together with alcohol (1.8%) or a prescription drug (2%). The psychoactive prescription drugs identified were mainly benzodiazepines, z-hypnotics and tramadol, which were found in the blood of 7.6% of crash victims. Conclusions: The high median BAC in fatally-injured drivers speaks strongly towards alcohol-induced impairment as being responsible for the crash. Compared with alcohol, the prevalence of illicit and psychoactive prescription drugs was fairly low despite a dramatic increase in the number of drug-impaired drivers arrested by the police after a zero-tolerance law was introduced in 1999.

  • 964.
    Ahlner, Johan
    et al.
    Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
    Zackrisson, Anna Lena
    Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
    Lindblom, Bertil
    Linköping University, Department of Clinical and Experimental Medicine, Forensic Genetics. Linköping University, Faculty of Health Sciences.
    Bertilsson, Leif
    Karolinska Institute.
    Editorial Material: CYP2D6, serotonin and suicide2010In: Pharmacogenomics (London), ISSN 1462-2416, E-ISSN 1744-8042, Vol. 11, no 7, p. 903-905Article in journal (Other academic)
    Abstract [en]

    n/a

  • 965.
    Ahlquist, Joel
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Införandet av NVDB i kommunerna - en fallstudie av Kiruna2005Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This case study of the Swedish national road database (NVDB) and local road database (LVDB) from the municipal viewpoint describes the advantages and disadvantages of joining NVDB. The possible profits and costs that can be deduced with a contract to the NVDB are also studied in this thesis. An applied method of how an inventory and a revision of local traffic regulations with adaptation to NVDB is made in this thesis.

    The basic thought of NVDB is that it is a database with information of all the roads in Sweden. The stored information in this database is mainly the geographic placement and the characteristics of the road. Examples of road characteristics are: road name, width, speed restrictions, obstacles in height and more. The database is constructed by links and nodes that are connected together in a road network. Turn restrictions are built in the links and with that it makes the database more intelligent.

    An inventory and revision of the local traffic regulations to match the new traffic decree has to be done before the end of 2005. But there is no requirement from the national road administration that the municipalities have to adapt their local traffic regulations to the NVDB. But it is highly recommended to do that since there is no extra time needed to do an adaptation to the NVDB when the inventory and revision is made.

    The benefits of joining NVDB are great for smaller municipalities. The benefit of having a complete intelligent database compensates the costs and resources that is needed to introduce the database to the municipality. Large costs can be saved by having a good overview of the road network. For example by decreasing the payouts in operational subsidies and lower the costs for school transports. To be emphasized is that NVDB creates a need to itself; new territories of use can be discovered after the municipality has joined NVDB. Needs in the future that doesn’t exist today will possibly be filled by the database.

    LVDB is a relatively untested NVDB application. Only Stockholms and Gothenbourgs municipalities use a LVDB today. The thought with the application is to connect purpose data of the road network with other data, for example electric lines and the placement of wells in a structured way. The disadvantage today with a LVDB is that it is designed for larger municipalities. For that reason the advice for smaller municipalities is to wait until a more suitable application can be investigated. That kind of application will be developed in a near future.

  • 966.
    Ahlquist, Mari
    Linköping University, Department of Mathematics. Linköping University, Faculty of Science & Engineering.
    On Knots and DNA2017Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    Knot theory is the mathematical study of knots. In this thesis we study knots and one of its applications in DNA. Knot theory sits in the mathematical field of topology and naturally this is where the work begins. Topological concepts such as topological spaces, homeomorphisms, and homology are considered. Thereafter knot theory, and in particular, knot theoretical invariants are examined, aiming to provide insights into why it is difficult to answer the question "How can we tell knots appart?". In knot theory invariants such as the bracket polynomial, the Jones polynomial and tricolorability are considered as well as other helpful results like Seifert surfaces. Lastly knot theory is applied to DNA, where it will shed light on how certain enzymes interact with the genome.

  • 967.
    Ahlqvist, Cecilia
    Linköping University, Department of Culture and Communication.
    Hyenor och kaniner i den platsspecifika konsten2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Uppsatsen berör den platsspecifika konstens spännvidd genom en fallstudie av två verk. Det ena verket har tillkommit genom en tävling som arrangerats av företag, organisationer, institutioner och kommuner. Det andra verket är ett privatfinansierat gatukonstverk som upplåtits utan tillstånd. Genom uppsatsen förs en diskussion om de båda verkens tillkomst och syfte samt hur de respektive städerna Stockholm och Söderköping förhållit sig till verken.

  • 968.
    Ahlqvist, Cecilia
    et al.
    Linköping University, The Tema Institute, Department of History. Linköping University, Faculty of Arts and Sciences.
    Ivarsson Lilieblad, Björn
    Linköping University, The Tema Institute, Department of History. Linköping University, Faculty of Arts and Sciences.
    Att fostra och forma en kommande generation svenskar : Folkskolans Barntidning 1892-1914 / I vansinnets gränsland : En studie av de normativa gränsdragningarna vid Vadstenacentralhospital 1849–18582003Book (Other academic)
    Abstract [sv]

    Att fostra och forma en kommande generation svenskar : Folkskolans Barntidning 1892–1914 Av Cecilia Ahlqvist

    Runt sekelskiftet 1900 synliggjordes den privata sfären mer och ett större intresse för att inplantera hemidealen i samhället märktes. Diskussioner fördes om barns uppfostran samt omhändertagande och särskiljande av barn som inte följde gängse normer. Det fanns redan färdiga ideal om hur ett gott barn skulle formas. Likaså fanns idéer om hur föräldrarna skulle agera för att ge barnet de bästa förutsättningarna. Genom hjälpinsatser, råd och anvisningar från bl.a. läkare och pedagoger skulle ett gott samhälle skapas.

    Jag vill studera om dessa tidstypiska idéer uttrycks i Folkskolans barntidning och i så fall på vilket sätt. Kan det vara så att tidningen var något mer än ”god nöjesläsning”? Vad hade redaktionen för åsikter och föreställningar? Vad ville man egentligen uppnå med sitt material? För att se ifall tidningen var ett verktyg i uppfostringsprocessen har jag formulerat följande frågeställningar;

    • Hur skilde tidningen på skötsamma och ouppfostrade barn?
    • Hur skulle barnen uppfostras till hälsa och hygien?
    • På vilket sätt handlade förnuftiga vuxna?
    • Hur användes historien som normerande?

    Min förväntning är att dessa frågor kan täcka området som rör just uppfostran. De kommer att ge en bild av hur tidningen tyckte att barn var och hur de borde vara. Vilka egenskaper framhävs och vad bör inte komma fram? De råd som ges angående hälsa och hygien anser jag kunna visa hur man ville kontrollera hela barnet och dess tillvaro. Att jag väljer att föra över fokus på vuxna i de sista frågeställningarna beror på att jag vill se ifall en uttalad barntidning även kunde ha åsikter om hur en god vuxen var. Troligt är att de inte ville att de idéer de förespråkade motverkades av okunniga föräldrar. Det visar även hur barnen reagerade på den normerande vuxne. Jag tror att dessa frågeställningar kommer att vara tillräckliga för att nå tidningens syfte och mål.

  • 969.
    Ahlqvist, Johan
    Linköping University, Department of Electrical Engineering, Communication Systems.
    Evaluation of the Turbo-decoder Coprocessor on a TMS320C64x Digital Signal Processor2011Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    One technique that is used to reduce the errors brought upon signals, when transmitted over noisy channels, is error control coding. One type of such coding, which has a good performance, is turbo coding. In some of the TMS320C64xTM digital signal processors there is a built in coprocessor that performs turbo decoding.

    This thesis is performed on the account of Communication Developments, within Saab AB and presents an evaluation of this coprocessor. The evaluation deals with both the memory consumption as well as the data rate. The result is also compared to an implementation of turbo coding that does not use the coprocessor.

  • 970.
    Ahlqvist, Malin
    Linköping University, Department of Management and Economics.
    Alternatives to the use of unequal voting rights: a propos the potential threat to their effectiveness as a takeover defense2004Independent thesis Advanced level (degree of Magister)Student thesis
    Abstract [en]

    Background: The origin of this study was the negotiations around a EU takeover directive, aimed at making the market for corporate control more open. One of the proposals was to neutralise shares carrying multiple rights in takeover situations when a potential acquirer obtains 75% of the total share capital. For many Swedish ownership groups, this would mean that the system of unequal voting rights, constituting an important defense to their control, would decrease in effectiveness. In the middle of writing this thesis, an EU agreement was finally reached, making the proposal voluntary to adopt. The imminent threat posed to the Swedish system faded, but has though not disappeared since the present rules anew will be brought under inspection in five years.

    Purpose: To give examples on potential tactics to adopt if unequal voting rights would risk to become neutralised in takeover situations, these tactics dependent on two different scenarios: (1) Present Swedish ownership structure is considered advantageous for the country and thus to be remained or (2) A more open market for takeovers is desired. Course of action: Interviews have been conducted with parties within Swedish trade and industry, partly in order to assess the value and necessity of the content of this thesis.

    Conclusion: The threat of an abolition of the unequal voting rights is not perceived as imminent by parties within Swedish trade and industry and few alternative resistance strategies are suggested. If current Swedish ownership structure is to be remained, the author proposes competition-reducing defenses, if a more open market for takeovers is aimed for, auction-inducing resistance strategies. The choice of how to proceed should depend on how afraid the Swedish Government and Swedish companies are of a change in present ownership structure.

  • 971.
    Ahlqvist, Niklas
    et al.
    Linköping University, Department of Management and Economics.
    Magnusson, Peter
    Linköping University, Department of Management and Economics.
    Värdet av företagsrating2004Independent thesis Advanced level (degree of Magister)Student thesis
    Abstract [en]

    Background: Increasingly, companies choose to finance their business with corporate bonds which has resulted in an increased demand on credit ratings. As such the rating agencies have a very important role in the financial markets. Examining the value of a credit-rating can be very interesting for both issuer and investor.

    Purpose: The purpose of the study is to identify and define the value of rating.

    Execution: The study is built upon nine interviews with rated and non-rated firms and investors.

    Result: The most important value of rating is the greater access to the corporate- and CP market. This infers that additional capital can be issued, in comparison to that available from bank loans, however, not necessarily at a lower rate. Consequently, the rate is not the driving factor concerning the choice of buying a rating. Rating has great effect on the pricing of bonds and CP’s, which is a result of the reliance investors have on the rating agencies. Rating affects the investment decision directly through the investment mandates, and indirectly through the effect on the individual investment decision.

  • 972.
    Ahlqvist, Sofia
    Linköping University, Department of Management and Engineering.
    CFC-lagstiftningens anpassning till EG-rätten: Vilka är problemområdena och vilka alternativa lösningar finns?2007Independent thesis Advanced level (degree of Magister), 10 points / 15 hpStudent thesis
    Abstract [sv]

    En typ av beskattningsregler som finns i de flesta av EU:s medlemsstater är Controlled Foreign Corporation(CFC)-lagstiftning. CFC-lagstiftningen reglerar beskattning av delägare i utländska juridiska personer med lågbeskattade inkomster. Den svenska CFC-lagstiftning är bl.a. till för att motverka och hindra internationell skatteflykt. Det kan t.ex. handla om svenska företag som äger företag med säte i s.k. skatteparadis eller lågskatteländer.

    CFC-lagstiftning har länge kritiserats för att strida mot dels etableringsfriheten, dels fri rörlighet för kapital. Redan under arbetet med den nya svenska CFC-lagstiftningen som trädde i kraft 1 januari 2004 ifrågasattes reglernas kompatibilitet med EG-rätten. I september 2006 avgjorde EG-domstolen ett mål, det s.k. Cadbury Schweppes-målet, rörande den brittiska CFC-lagstiftningens kompatibilitet med gemenskaprätten. Detta avgörande kan antas komma att ha stor betydelse i framtiden, inte bara för Storbritannien, utan även för övriga EU-medlemsländer.

    I uppsatsen analyseras hur den svenska CFC-lagstiftningen kan anpassas efter EG-rätten. Vidare utreds och identifieras de problemområden som finns i dagens uppbyggnad av CFC-lagstiftningen samt analyseras betydelsen och konsekvenserna av Cadbury Schweppes-fallet gällande CFC-lagstiftning som EG-domstolen har avgjort.

  • 973.
    Ahlqvist-Rastad, Jane
    et al.
    Medical Products Agency, Uppsala, Sweden.
    Albertsson, Maria
    Karolinska University Hospital, Stockholm, Sweden.
    Bergh, Jonas
    Karolinska University Hospital, Stockholm, Sweden.
    Birgegård, Gunnar
    Uppsala University Hospital, Uppsala, Sweden.
    Johansson, Peter
    Sahlgrenska University Hospital, Gothenborg, Sweden.
    Jonsson, Bertil
    Medical Products Agency, Uppsala, Sweden.
    Kjellen, Elisabeth
    Lund University Hospital, Sweden.
    Påhlman, Sven
    Malmö University Hospital MAS, Sweden.
    Zackrisson, Björn
    University Hospital of Northern Sweden, Umeå, Sweden.
    Österborg, Anders
    Karolinska University Hospital, Stockholm, Sweden.
    Erythropoietin therapy and cancer related anaemia: updated Swedish recommendations2007In: Medical Oncology, ISSN 1357-0560, E-ISSN 1559-131X, Vol. 24, no 3, p. 267-272Article in journal (Refereed)
    Abstract [en]

    Due to concerns related to treatment with erythropoietin (EPO) and possible negative effects on tumour control, a workshop was organised by the Medical Products Agency of Sweden with the aim to revise national treatment guidelines if needed. In patients with solid tumours, conflicting results have been reported with respect to tumour control and survival. Until further notice it is therefore recommended that EPO should be used restrictively in the treatment of patients with cancer and that the anticipated improvement in quality of life should be evaluated against potential risks.

  • 974.
    Ahlrot, Ulrica
    Linköping University, Department of Physics, Chemistry and Biology, Biology.
    Welfare in zoo kept felids: A study of resource usage2016Independent thesis Advanced level (degree of Master (Two Years)), 40 credits / 60 HE creditsStudent thesis
    Abstract [en]

    Due to a large number of felid species being endangered they are subjects of conservation projects both in situ and ex situ. Keeping felids in zoos are problematic with stereotypic behaviours such as pacing and reproduction difficulties often occurring. The aim of this study was to review research and zoo husbandry knowledge about which resources are most important for the welfare of zoo kept felids, and in addition perform behavioural observations in seven felid species in four Swedish zoos to try to find an order of priority of resources. Observations were performed during opening hours in 36 sessions per species and zoo. The results showed that studies of felid resource usage are missing. Zoo husbandry practice is probably based mainly on traditions and anecdotal knowledge. The observations showed that except for minor differences felids behave similarly regardless of species but the use of resources varies. Small felid species seems to be hiding rather than pacing as a way of coping. Elevated resources and areas as well as numerous hiding places are important to felids but many factors might affect the choice of resting places. Therefore it is important to provide the felids with multiple choices. It is also important to evaluate both species and individuals when designing enclosures and providing resources. More multi-institutional studies with large number of individuals of all zoo kept felid species are needed to gather knowledge about felids needs and preferences of resources.

  • 975.
    Ahlroth, Sofia
    et al.
    Royal Institute of Technology.
    Nilsson, Måns
    Stockholm Environment Institute (SEI).
    Finnveden, Göran
    Royal Institute of Technology.
    Hjelm, Olof
    Linköping University, Department of Management and Engineering, Environmental Technique and Management . Linköping University, The Institute of Technology.
    Hochschorner, Elisabeth
    Royal Institute of Technology.
    Weighting and valuation in selected environmental systems analysis tools - suggestions for further developments2011In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 19, no 2-3, p. 145-156Article in journal (Refereed)
    Abstract [en]

    In environmental systems analysis tools like Life Cycle Assessment, strategic environmental assessment, cost–benefit analysis and environmental management systems, results need to be presented in a comprehensible way to make alternatives easily comparable. One way of doing this is to aggregate results to a manageable set by using weighting methods. In this paper, we explore how weighting methods are used in some selected Environmental Systems Analysis Tools (ESATs), and suggest possible developments of their use. We examine the differences in current use patterns, discuss the reasons for and implications of such differences, and investigate whether observed differences in use are necessary. The result of our survey shows that weighting and valuation is broadly used in the examined ESATs. The use of weighting/valuation methods is different in different tools, but these differences are not always related to the application; rather, they are related to traditions and views on valuation and weighting. Also, although the requirements on the weights/values may differ between tools, there are intersections where they coincide. Monetary weights, using either endpoint or midpoint methods, are found to be useful in all the selected tools. Furthermore, the inventory shows that that there is a common need for generic sets of weights. There is a need for further research focusing on the development of consistent value sets derived with a wide range of methods. In parallel to the development of weighting methods it is important with critical evaluations of the weighting sets with regard to scientific quality, consistency and data gaps.

  • 976.
    Ahlsell, Chandra
    et al.
    Linköping University, Department of Management and Engineering, Carl Malmsten - furniture studies. Linköping University, Faculty of Science & Engineering.
    Knutsson, JohanLinköping University, Department of Management and Engineering, Carl Malmsten - furniture studies. Linköping University, Faculty of Science & Engineering.Knutsson, JohanLinköping University, Department of Management and Engineering, Carl Malmsten - furniture studies. Linköping University, Faculty of Science & Engineering.Sandin Bülow, KerstiLinköping University, Department of Management and Engineering, Carl Malmsten - furniture studies. Linköping University, Faculty of Science & Engineering.
    Carl Malmsten Furniture Studies: Josef Frank : studenter och lärare vid Carl Malmsten Furniture studies utforskar Josef Frank2016Collection (editor) (Other (popular science, discussion, etc.))
  • 977.
    Ahlsson, Anders
    et al.
    Örebro University Hospital.
    Jideus, Lena
    Uppsala University Hospital .
    Albåge, Anders
    Karolinska University Hospital, Stockholm.
    Källner, Göran
    Karolinska University Hospital, Stockholm.
    Holmgren, Anders
    Umeå University Hospital .
    Boano, Gabriella
    Östergötlands Läns Landsting.
    Hermansson, Ulf
    Linköping University, Department of Medical and Health Sciences, Thoracic Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Thoracic and Vascular Surgery in Östergötland.
    Kimblad, Per-Ola
    Lund University Hospital.
    Schersten, Henrik
    Sahlgrenska University Hospital, Gothenburg.
    Sjögren, Johan
    Lund University Hospital .
    Ståhle, Elisabeth
    Uppsala University Hospital.
    Åberg, Bengt
    Blekinge Hospital, Karskrona, Sahlgrenska University Hospital, Gothenburg.
    Berglin, Eva
    Sahlgrenska University Hospital, Gothenburg.
    A Swedish consensus on the surgical treatment of concomitant atrial fibrillation2012In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 46, no 4, p. 212-218Article, review/survey (Refereed)
    Abstract [en]

    Atrial fibrillation (AF) is a common arrhythmia among patients scheduled for open heart surgery and is associated with increased morbidity and mortality. According to international guidelines, symptomatic and selected asymptomatic patients should be offered concomitant surgical AF ablation in conjunction with valvular or coronary surgery. The gold standard in AF surgery is the Cox Maze III ("cut-and-sew") procedure, with surgical incisions in both atria according to a specified pattern, in order to prevent AF reentry circuits from developing. Over 90% of patients treated with the Cox Maze III procedure are free of AF after 1 year. Recent developments in ablation technology have introduced several energy sources capable of creating nonconducting atrial wall lesions. In addition, simplified lesion patterns have been suggested, but results with these techniques have been unsatisfactory. There is a clear need for standardization in AF surgery. The Swedish Arrhythmia Surgery Group, represented by surgeons from all Swedish units for cardiothoracic surgery, has therefore reached a consensus on surgical treatment of concomitant AF. This consensus emphasizes adherence to the lesion pattern in the Cox Maze III procedure and the use of biatrial lesions in nonparoxysmal AF.

  • 978.
    Ahlstedt, Kristoffer
    et al.
    Linköping University, Department of Computer and Information Science.
    Annerwall, Lovisa
    Linköping University, Department of Computer and Information Science.
    Axelsson, Daniel
    Linköping University, Department of Computer and Information Science.
    Björklund, Samuel
    Linköping University, Department of Computer and Information Science.
    Cedenheim, Oliver
    Linköping University, Department of Computer and Information Science.
    Eriksson, Josefin
    Linköping University, Department of Computer and Information Science.
    Lehtonen, Jesper
    Linköping University, Department of Computer and Information Science.
    Lorentzon, Linn
    Linköping University, Department of Computer and Information Science.
    Olofsson, Gustaf
    Linköping University, Department of Computer and Information Science.
    BryggaHem – Development of an E-commerce Web Application with a Usability Focus2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis is part of a bachelor’s project conducted at Linköping University and addresses the development of an e-commerce web application with a usability focus. A market survey was conducted as part of the project to establish the orientation of the web application. Furthermore, the Scrum methodology is described and analyzed, and the team’s experiences of the project are documented. Research relevant to designing an application with high usability is detailed. Additionally the thesis addresses the tools and frameworks used during the development of the application, as well as ethical aspects of handling user information and selling products related to home-brewing of alcoholic beverages. The conclusion drawn from the project regarding the methodology is that Scrum is a viable methodology for this type of development work, although it requires small teams as well as previous experience of Scrum to yield high efficiency. The conclusion drawn from the project regarding usability is that it is achieved through a combination of variables that to a large extent is based on users’ distinct perceptions of the given application. 

  • 979.
    Ahlstedt, Sara
    Linköping University, Department of Social and Welfare Studies, REMESO - Institute for Research on Migration, Ethnicity and Society. Linköping University, Faculty of Arts and Sciences.
    Bredda normen: En kunskapssammanställning om unga hbtq-personers etablering på arbetsmarknaden2018Report (Other academic)
  • 980.
    Ahlstedt, Sara
    Linköping University, Department of Social and Welfare Studies, REMESO – Institute for Research on Migration, Ethnicity and Society. Linköping University, Faculty of Arts and Sciences.
    The Feeling of Migration: Narratives of Queer Intimacies and Partner Migration2016Doctoral thesis, monograph (Other academic)
    Abstract [en]

    This dissertation analyzes narratives of queer partner migration, that is, a family-tie migration in which one of the partners of a relationship has migrated in order for the partners to be together, and where the partners queer the migration in the sense that they have a non-normative sexuality and/or gender identity. The purpose of the study is to examine how queer partner migrants and their Swedish partners experience the migration process – which continues also once the administrative process has been completed – by analyzing the emotions and feelings that emerge in the process. The study is a contribution to research on privileged migration as well as intimate migration.

    The focus is the queer partner migration relationship, and what emotions and feelings ‘do’ to this relationship, but also how emotions and feelings structure the migration process. The study analyzes the work three different emotions – love, loss, and belonging – do in these migration processes, and how this work is described in the participant narratives. Migrant participants have migrated from different parts of the world (Africa, Europe, Latin America, and North America), making it possible to analyze what emotions and feelings do in this particular migration process from the point of view of nationality and, in particular, proximity to ‘Western-ness,’ race, and language as well as how privileges connected to these positions come to matter in the process.

    The dissertation is an ethnographic interview study in which both migrants and Swedish partners have been interviewed. The interview material consists of a combination of couple interviews and individual interviews.

    By using affect theories and the concept of queer phenomenology, the dissertation shows how the work that emotions and feelings do in migration processes is connected to gender identity, sexual identity, race and whiteness, nationality, perceived proximity to Western-ness, class, language, and the migration narrative the migrating partner is (or is not) written into by way of the country they have migrated from. This is analyzed in relation to the theoretical frameworks of entanglement, homonationalism, and intimate citizenship.

    The analysis shows that emotions and feelings structure the migration process for both more privileged and less privileged migrants, but in different ways. The understanding of who ‘is’ a migrant, and the preparedness for the feelings that arise in a migration process, are tied to the positions mentioned above and the privileges these positions give, or do not give, the migrant access to. By focusing on emotions and feelings and what these do, the study also illustrates how the migration process affects the non-migrating partner as this partner engages in emotional labour to ‘make’ the migrating partner ‘Swedish.’ Through their the migrating partner, the non-migrating partner is also aligned in a way that makes them a little bit less ‘Swedish,’ contributing to the non-migrating partner being ‘stopped’ in ways they have usually not experienced before. The study further shows how migration processes produces inequality, and the difficulties that arise when the couples try to live up to the Swedish ideal of the equal relationship.

    The interviews are analyzed as narratives, and both narratives and storytelling are important throughout the dissertation, not only as the method used in the analysis but as the form of the dissertation, making it a kind of super structure organizing the writing. Writing (how to write accessibly and interesting) and reading (how to write in order to invite an open and active reading) are important aspects of the dissertation.

  • 981.
    Ahlstedt, Sara
    et al.
    Linköping University, REMESO - Institute for Research on Migration, Ethnicity and Society. Linköping University, Department of Social and Welfare Studies. Linköping University, Faculty of Arts and Sciences.
    Qvist, Martin
    Stockholms universitet.
    Suter, Brigitte
    Malmö högskola.
    Migration: Suveränitet, gränser och kontroll2013In: Migrationens och etnicitetens epok: Kritiska perspektiv i etnicitets- och migrationsstudier / [ed] Magnus Dahlstedt och Anders Neergaard, Stockholm: Liber, 2013, p. 54-81Chapter in book (Other academic)
  • 982.
    Ahlstrand, Alexander
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Ivarsson, Erik
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Lärares högläsning som undervisningsform: Undervisningsstrategier som främjar elevers språkutveckling2019Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Högläsning kan ses som ett verktyg för att utveckla elevers språk och har samtidigt visat sig vara betydelsefull för elevers egen läsutveckling. Att lärare högläser för elever är därför av största vikt. Syftet med denna studie är att undersöka vilka strategier forskare förespråkar att lärare kan använda sig av under högläsningen för att främja elevers språk. Syftet är också att undersöka vilka betydelser deförespråkade strategierna kan ha på elevers lärande. Högläsning avser i denna studie den form när läraren läser högt för eleverna. Formen inkluderar även interaktioner mellan lärare och elever likt ett socialkonstruktivistiskt synsätt på lärande där elever lär i samspel med andra. Förståelsen och förmågan att röra sig i andra texter är också viktiga aspekter som utvecklar elevers literacy. I denna studie har vi använt oss av manuella sökningar och sökningar i databasen ERIC. Litteraturstudien är baserad på resultat från elva olika studier. Resultatet visar att de förespråkade strategierna kan delas upp i tre kategorier: 1. Förberedelser innan högläsning. 2. Texters struktur och innehåll. 3. Ordförrådsstrategier. Utifrån studiens resultat rekommenderar vi att lärare med fördel kan tillämpa strategier från respektive resultatdel. Lärare har inför högläsning didaktiska val att ta ställning till, exempelvis strategin bokval. För att främja förståelsen av texters struktur och innehåll kan lärare till exempel utnyttja strategierna berättelsens komponenteroch dramatisera. Slutligen bör lärare använda sig av planerade ordförrådsstrategier där exempelvis ord placeras i ny kontext eller att elever konstruerar nya meningar med ord.  

  • 983.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Arbetslaget: en arena för påbjudet och/eller informellt samarbete?1993In: NFPFs kongress,1993, 1993Conference paper (Other academic)
  • 984.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Kulturer möts och påverkas2003In: Antologi Lagarbete och tidig läs- och skrivutveckling / [ed] Johan M Sandell; Birgitta Lidholt; Sverige Skolverket, Stockholm: Skolverket , 2003, p. -109Chapter in book (Other academic)
    Abstract [sv]

    Olika modeller för samarbete, samverkan och integration mellan förskole-, skolbarnsomsorgs- och skolkulturerna har utretts och debatterats under en följd av år.Syftet med integrationsreformen var att nya arbetsformer och ett gemensamt synsätt på barns och ungdomars utveckling och lärande från tidig ålder skulle utvecklas i mötet mellan de olika skol- och barnomsorgskulturerna.

  • 985.
    Ahlstrand, Elisabeth
    Linköping University, Department of Educational Science (IUV). Linköping University, Faculty of Educational Sciences.
    Lärares samarbete - en verksamhet på två arenor: studier av fyra arbetslag på grundskolans högstadium1995Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Around 1980 some important decisions were made regarding the Swedish comprehensive school, which in various ways influenced teachers' work. The school was to be divided into smaller units, so-called work-units. A work-unit was to contain two or more classes of students. As a consequence of this new organisation the teachers were to co-operate in a so called teacher-team, that was responsible for all activities in a work-unit.

    The aim of this thesis is to study teachers' work as regards their participation in and conceptions of collegial co-operation. Focus is on describing and analysing the meeting between external demands on teacher co-operation and the traditional freedom of the teaching profession to plan and carry through teaching individually.

    Four teacher-teams were studied during one year by means of participating observations of their planned conferences. Three teachers from each team were then interviewed about their views on and conceptions of work in teacher-team and of their tasks as teachers. All teachers in the four teams were also asked to keep a diary for one week where all collegial meetings were noted.

    The results indicate that when imposed collegial co-operation was introduced in the school it led to teacher collaboration being distributed into two separate arenas: conference co-operation (the formal arena) and other types of co-operation with colleagues (the informal arena). All teachers use the formal arena to introduce discussions about student welfare. otherwise they are moderately interested in the work in this arena. In the informal arena some teachers act as initiators of ontent, closely related to well-known interests among teachers; instruction and student welfare.

    Teachers express a need for collegial co-operation and they take the opportunity under certain circumstances.

  • 986.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings. Linköping University, Department of Behavioural Sciences and Learning, Education and Adult Learning.
    Lärares samarbete över professionsgränser2007In: Forskning om lärares arbete i klassrummet / [ed] Kjell Granström, Stockholm: Myndigheten för skolutveckling , 2007, p. 127-138Chapter in book (Other academic)
    Abstract [sv]

    Varje dag går en miljon elever och lärare till arbete i den svenska skolan. De allra flesta arbetar engagerat och når goda resultat. Eleverna lär sig, med stöd från sina lärare, läsa, skriva och räkna. De skaffar sig kunskap om sociala och naturvetenskapliga fenomen. De utvecklar kreativitet och estetisk kompetens. Naturligtvis finns både elever och lärare som upplever svårigheter i detta arbete, men de allra flesta får uppleva att arbetet fortskrider på önskat sätt. Den här boken handlar om elevernas och lärarnas arbete i klassrummet när det gäller skolans primära uppgift; att ge möjlighet till lärande och utveckling. Den handlar om arbetet med grundläggande färdigheter och lärande, om läraren som arbetsledare och ansvarig för val av arbetsformer, läxor, möblering liksom deras arbete med värdefrågor, genusfrågor och konfliktlösning. Den handlar också om lärares inbördes samarbete. Kort sagt en bok som handlar om lärarens breda uppdrag. Boken är skriven av forskare som alla arbetar med lärarutbildning och som själva har erfarenheter från arbete i skolan.

  • 987.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    New demands - new culture? Collaboration between primary school teachers, pre-school teachers and recreation instructors in teacher teams1999In: The Biennial Conference of the International Study Association on Teacher Thinking,1999, 1999Conference paper (Other academic)
  • 988.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Passionate Enquiry and School Development1997In: Teachers and Teaching: theory and practice, ISSN 1354-0602, E-ISSN 1470-1278, Vol. 3, no 2Article in journal (Other academic)
  • 989.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Professional cultures meet and change2002In: EECERA, 12th Conference on Quality in Early Childhood Education, Strategies for Effective learning in early Childhood,2002, 2002Conference paper (Other academic)
  • 990.
    Ahlstrand, Elisabeth
    Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings. Linköping University, Faculty of Educational Sciences.
    Professional Isolation and Imposed Collaboration in Teachers' Work1994In: Teachers' Minds and Actions / [ed] Ingrid Carlgren, Gunnar Handal och Sveinung Vaage, London, Washington: Falmer Press , 1994Chapter in book (Other academic)
  • 991.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Professional isolation and imposed collaboration in teachers' work1993In: ISATT,1993, 1993Conference paper (Other academic)
  • 992.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Teacher cooperation and school organization: When and why do teachers cooperate?1991In: AERA,1991, 1991Conference paper (Other academic)
  • 993.
    Ahlstrand, Elisabeth
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Tid, ledning och organisation för det integrerade arbetslaget2003In: Lagarbete och tidig läs- och skrivutveckling / [ed] Johan M Sandell; Birgitta Lidholt; Sverige Skolverket, Stockholm: Skolverket , 2003, p. -109Chapter in book (Other academic)
    Abstract [sv]

    Olika modeller för samarbete, samverkan och integration mellan förskole-, skolbarnsomsorgs- och skolkulturerna har utretts och debatterats under en följd av år.Syftet med integrationsreformen var att nya arbetsformer och ett gemensamt synsätt på barns och ungdomars utveckling och lärande från tidig ålder skulle utvecklas i mötet mellan de olika skol- och barnomsorgskulturerna.

  • 994.
    Ahlstrand, Elisabeth
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Teaching and Learning in School, Teacher Education and other Educational Settings. Linköping University, Faculty of Educational Sciences.
    Andersson, Ingrid
    Linköping University, Department of Behavioural Sciences and Learning, Avdelningen för didaktik och forskning om pedagogiskt arbete (DIPA). Linköping University, Faculty of Educational Sciences.
    Eriksson Gustavsson, Anna-Lena
    Linköping University, Department of Behavioural Sciences and Learning, Teaching and Learning in School, Teacher Education and other Educational Settings. Linköping University, Faculty of Educational Sciences.
    Persson, Ulla-Britt
    Linköping University, Department of Behavioural Sciences and Learning, Teaching and Learning in School, Teacher Education and other Educational Settings. Linköping University, Faculty of Educational Sciences.
    Erfarna lärares engagemang: livsberättelser som retrospektiv reflektion2008In: Läraren i blickpunkten : olika perspektiv på lärares liv och arbete / [ed] Carola Aili, Ulf Blossing, Ulrika Tornberg, Stockholm: Lärarförbundets Förlag , 2008, 1, p. 189-205Chapter in book (Other academic)
    Abstract [sv]

    Lärares arbete är komplext och kan beskrivas på olika sätt beroende på vilken utgångspunkt man väljer. I takt med att det ställs allt högre krav på lärare att utgå från en vetenskaplig bas i arbetet, behövs också fler redskap och begrepp för att förstå och förklara läraryrket. Hur ser arbetsprocesserna ut? Vad formar yrket? Vilka insatser kan göras för att förbättra verksamheten? Den här antologin presenterar femton sätt att se på lärares liv och arbete med hjälp av olika teoretiska perspektiv.Boken vänder sig till lärare och blivande lärare samt till alla som är intresserade av kunskapsutvecklingen kring lärares arbete.

  • 995.
    Ahlstrand, Elisabeth
    et al.
    Linköping University, Department of Behavioural Sciences.
    Bergqvist, Kerstin
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Learning by means of a thesis2005In: Learning by means of a thesis in teacher education,2005, 2005Conference paper (Other academic)
  • 996.
    Ahlstrand, Elisabeth
    et al.
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Bergqvist, Kerstin
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    "Suddenly we were at the university!" The thesis as a vehichle for changing teacher education1996In: ECER,1996, 1996Conference paper (Other academic)
  • 997.
    Ahlstrand, Elisabeth
    et al.
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Bergqvist, Kerstin
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    The Thesis - a Vehicle for Changing Teacher Education?1997In: The Biennial Conference of the International Study Association on Teacher Thinking,1997, 1997Conference paper (Other academic)
  • 998.
    Ahlstrand, Elisabeth
    et al.
    Linköping University, Department of Behavioural Sciences.
    Bergqvist, Kerstin
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    Thesis in teacher education - research orientation and professional relevance2004In: NFPF,2004, 2004Conference paper (Other academic)
  • 999.
    Ahlstrand, Elisabeth
    et al.
    Linköping University, Department of Behavioural Sciences. Linköping University, Faculty of Educational Sciences.
    Bergqvist, Kerstin
    Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings. Linköping University, Faculty of Educational Sciences.
    Thesis in teacher education: research orientation and professional relevance2005Report (Other academic)
    Abstract [sv]

    One aim of this project was to integrate research orientation and professional relevance in teacher education, in relation to educational theory, thesis writing and future work. Another aim was to develop models for group-supervision to let students participate in discussions about their work, which was expected to promote student influence and development of analytic thinking. Data were collected by means of a questionnaire before the students started working on their thesis. Supervisors’ notes from group supervision were collected after their series of meetings.

    The students claim that the thesis gives them new knowledge and skills which are important in their profession. It has also improved the overall quality of their education. The thesis work, as well as group supervision, when students’ needs are considered, facilitates student influence.

  • 1000.
    Ahlstrand, Elisabeth
    et al.
    Linköping University, Department of Behavioural Sciences.
    Bergqvist, Kerstin
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Teaching and Learning in School, Teacher Education and other Educational Settings.
    What can students learn from writing a thesis in teacher education?2004In: ECER,2004, 2004Conference paper (Other academic)
17181920212223 951 - 1000 of 100911
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