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  • 99551.
    Ydreborg, Berit
    et al.
    Örebro läns landsting.
    Ekberg, Kerstin
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Department of Health and Society, National Centre for Work and Rehabilitation.
    Nilsson, Kerstin
    Sahlgrenska Akademin Göteborgs universitet.
    Swedish social insurance officers' experiences of difficulties in assessing applications for disability pensions - an interview study.2007In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 7, no 128Article in journal (Other academic)
    Abstract [en]

    In this study the focus is on social insurance officers judging applications for disability pensions. The number of applications for disability pension increased during the late 1990s, which has resulted in an increasing number of disability pensions in Sweden. A more restrictive attitude towards the clients has however evolved, as societal costs have increased and governmental guidelines now focus on reducing costs. As a consequence, the quantitative and qualitative demands on social insurance officers when handling applications for disability pensions may have increased. The aim of this study was therefore to describe the social insurance officers' experiences of assessing applications for disability pensions after the government's introduction of stricter regulations.    

  • 99552.
    Ydreborg, Berit
    et al.
    Linköping University, Department of Medicine and Health Sciences, Work and Rehabilitation . Linköping University, Faculty of Health Sciences.
    Ekberg, Kerstin
    Linköping University, Department of Medicine and Health Sciences, Work and Rehabilitation . Linköping University, Faculty of Health Sciences.
    Nordlund, Anders
    Linköping University, Department of Medicine and Health Sciences, Work and Rehabilitation . Linköping University, Faculty of Health Sciences.
    Health, quality of life, social network and use of public health: A comparison between those granted and those not granted disability pension2006In: Disability and Rehabilitation, ISSN 0963-8288, Vol. 28, no 1, p. 25-32Article in journal (Refereed)
    Abstract [en]

    Purpose. The aim was to compare self-rated health, health-related quality of life (HRQoL), social networks and health care utilisation of those granted disability pension (DP) and those not granted disability pension (nDP).

    Method. Demographic data and medical diagnoses were obtained from the records of the social insurance office. Data concerning self-reported health, HRQoL social networks, and use of health care were collected by a postal questionnaire. The nDP group included all those not granted full DPs between 1999 and 2000 (n = 99). The DP group were a random sample of those granted full DPs, during the same period (n = 197).

    Results. The nDP group had more often multiple diagnoses, and lower self-reported health and HRQoL compared to those granted DP. In particular, their average scores were lower on the SF-36 scales social functioning, role limitations due to physical problems and mental health. The nDP group also had significantly smaller social networks.

    Conclusions. Contrary to expectations, those not granted a disability pension do not seem to have better health, but rather to suffer from more sickness than those who were granted a disability pension.

  • 99553.
    Ydreborg, Karin
    et al.
    Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Engstrand, Christina
    Linköping University, Department of Medical and Health Sciences, Division of Physiotherapy. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Steinvall, Ingrid
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    Larsson, Eva-Lena
    Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Hand function, experienced pain, and disability after distal radius fracture.2015In: The American journal of occupational therapy, ISSN 0272-9490, Vol. 69, no 1, article id 6901290030Article in journal (Refereed)
    Abstract [en]

    Objective: We sought to explore differences in range of motion (ROM), grip strength, and self-reported pain and disability over time after plate-fixation surgery for distal radius fracture.less thanbr /greater thanMethod: We used a prospective repeated-measures research design with four measure points for a study sample of 101 patients. The Disabilities of the Arm, Shoulder and Hand (DASH) Questionnaire; the Global Assessment Scale; and the Canadian Occupational Performance Measure were used to assess ROM, grip strength, and pain level.less thanbr /greater thanResults: ROM and grip strength improved over time. Pain improved until 6 mo after surgery but greatly deteriorated from 6 to 24 mo. Concurrently, overall discomfort (global index) from the wrist extensively improved from 12 to 24 mo. DASH score decreased 20.1 points from 6 wk to 6 mo and remained stable until 24 mo.less thanbr /greater thanConclusion: Even when ROM and grip strength were almost fully regained at 12 mo, pain at rest and during activity was still an issue at 24 mo.less thanbr /greater than (Copyright © 2015 by the American Occupational Therapy Association, Inc.)

  • 99554.
    Ydreborg, Magdalena
    et al.
    University of Gothenburg.
    Westin, Johan
    University of Gothenburg.
    Rembeck, Karolina
    University of Gothenburg.
    Lindh, Magnus
    University of Gothenburg.
    Norgren, Hans
    University Hospital Lund .
    Holmberg, Anna
    University Hospital Lund .
    Wejstål, Rune
    University of Gothenburg.
    Norkrans, Gunnar
    University of Gothenburg.
    Cardell, Kristina
    Östergötlands Läns Landsting, Heart and Medicine Center, Department of Infectious Diseases. Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
    Weiland, Ola
    KI, Karolinska University Hospital.
    Lagging, Martin
    University of Gothenburg .
    Impact of IL28B-Related Single Nucleotide Polymorphisms on Liver Transient Elastography in Chronic Hepatitis C Infection2013In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 11, p. e80172-Article in journal (Refereed)
    Abstract [en]

    Background and Aims

    Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of hepatitis C virus (HCV) infection as well as outcome following pegylated interferon and ribavirin therapy among genotype 1 infected patients. Additionally the presence of the otherwise favorable IL28B genetic variants in the context of HCV genotype 3 infection reportedly entail more pronounced liver fibrosis and steatosis. The present study aimed to evaluate the impact of IL28B SNP variability on liver stiffness as accessed by transient elastography.

    Methods

    Seven hundred and seventy-one Swedish HCV infected patients sequentially undergoing liver stiffness measurement by means of Fibroscan® in the context of a real-life trial had samples available for IL28B genotyping (rs12979860) and HCV genotyping.

    Results

    CCrs12979860 was more common among HCV genotype 2 or 3 infected treatment-naïve patients than among those infected with genotype 1 (P<0.0001). Additionally CCrs12979860 among HCV genotype 3 infected patients was associated with higher liver stiffness values (P = 0.004), and higher AST to platelet ratio index (APRI; p = 0.02) as compared to carriers of the T allele. Among HCV genotype 1 infected patients, CCrs12979860 was significantly associated with higher viral load (P = 0.001), with a similar non-significant trend noted among HCV genotype 3 infected patients.

    Conclusion

    This study confirms previous reports that the CCrs12979860 SNP is associated with more pronounced liver pathology in patients chronically infected with HCV genotype 3 as compared to genotype 1, suggesting that IL28B genetic variants differently regulates the course of HCV infection across HCV genotypes.

  • 99555.
    Ydremark, Anders
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    Approaches for Automated Software Installations in Windows2014Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    Today Siemens Industrial Turbomachinery AB (SIT AB) installs operator-stations manually. This is a tedious and time consuming process. In this report several different approaches is researched and presented for an automated solution. Because automated installation is not a widely researched area, an exploration of different approaches and technical difficulties has  been made to use as a base when finally arriving at a recommendation for SIT AB. The result of this report shows that an approach using the Windows Registry is the best solution for implementation of an automated solution, and that other approaches either is too time consuming or technically challenging to be feasible.

    This report is meant as a decision basis for SIT AB in their automation of operator-station installations.

  • 99556.
    Ydrenius, Liselotte
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
    Majeed, Meytham
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
    J Rasmusson, Birgitta
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
    Stendahl, Olle
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology.
    Särndahl, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Cell biology.
    Activation of cAMP-dependent protein kinase is necessary for actin rearrangements in human neutrophils during phagocytosis2000In: Journal of Leukocyte Biology, ISSN 0741-5400, E-ISSN 1938-3673, Vol. 67, no 4, p. 520-528Article in journal (Refereed)
    Abstract [en]

    We have investigated the role of cAMP and cAMP-dependent protein kinase (cAPK) in neutrophil phagocytosis. Inhibition of cAPK with H-89 reduced complement- and IgG-dependent phagocytosis to 83 and 46%, respectively. Fluorescence intensity measurements of phalloidin-stained actin in neutrophils showed a reduced amount of filamentous actin (F-actin) in pseudopods and around the phagosome in cells treated with H-89 or cAMP-elevating agents (forskolin and rolipram). The amount of phosphotyrosine-containing proteins was also reduced in pseudopods and around the phagosome. Taken together, the data show that cAMP/cAPK regulates F-actin reorganization during receptor-mediated phagocytosis, particularly triggered by IgG-FcR interaction. Our results support the hypothesis that active subcortical reorganization of F-actin is a prerequisite for FcR-mediated phagocytosis, but is less important during CR3-mediated ingestion.

  • 99557.
    Ye, F.
    et al.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States.
    Wu, C.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States; State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun, Jilin 130012, China.
    Sun, W.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States.
    Yu, J.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States.
    Zhang, Xuanjun
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States.
    Rong, Y.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States.
    Zhang, Y.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States.
    Wu, I.-C.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States.
    Chan, Y.-H.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States; Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
    Chiu, D.T.
    Department of Chemistry, University of of Washington, Seattle, WA 98195, United States.
    Semiconducting polymer dots with monofunctional groups2014In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 50, no 42, p. 5604-5607Article in journal (Refereed)
    Abstract [en]

    This communication describes an approach for preparing monovalent semiconducting polymer dots (mPdots) with a size of 5 nm where each mPdot was composed of precisely a single active functional group. © the Partner Organisations 2014.

  • 99558.
    Ye, Fangmao
    et al.
    Department of Chemistry, University of Washington, Seattle, USA.
    Wu, Changfeng
    Department of Chemistry, University of Washington, Seattle, USA.
    Jin, Yuhui
    Department of Chemistry, University of Washington, Seattle, USA.
    Chan, Yang-Hsiang
    Department of Chemistry, University of Washington, Seattle, USA.
    Zhang, Xuanjun
    Department of Chemistry, University of Washington, Seattle, USA.
    Chiu, Daniel T
    Department of Chemistry, University of Washington, Seattle, USA.
    Ratiometric temperature sensing with semiconducting polymer dots2011In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 133, no 21, p. 8146-8149Article in journal (Refereed)
    Abstract [en]

    This communication describes ultrabright single-nanoparticle ratiometric temperature sensors based on semiconducting polymer dots (Pdots). We attached the temperature sensitive dye—Rhodamine B (RhB), whose emission intensity decreases with increasing temperature—within the matrix of Pdots. The as-prepared Pdot-RhB nanoparticle showed excellent temperature sensitivity and high brightness because it took advantage of the light harvesting and amplified energy transfer capability of Pdots. More importantly, the Pdot-RhB nanoparticle showed ratiometric temperature sensing under a single wavelength excitation and has a linear temperature sensing range that matches well with the physiologically relevant temperatures. We employed Pdot-RhB for measuring intracellular temperatures in a live-cell imaging mode. The exceptional brightness of Pdot-RhB allows this nanoscale temperature sensor to be used also as a fluorescent probe for cellular imaging.

  • 99559.
    Ye, L L
    et al.
    Chalmers University of Technology.
    Thölén, A
    Chalmers University of Technology.
    Jacob, A P
    Chalmers University of Technology.
    Myrberg, T
    Chalmers University of Technology.
    Nour, Omer
    Chalmers University of Technology.
    Willander, Magnus
    Chalmers University of Technology.
    Structural roughness and interface strain properties in Si/SiO2/poly-Si1-xGex tri-layer system with ultrathin oxide2003In: Journal of materials science. Materials in electronics, ISSN 0957-4522, E-ISSN 1573-482X, Vol. 14, no 4, p. 247-254Article in journal (Refereed)
    Abstract [en]

    We have explored the microstructure and local interface strain in the poly-Si1-xGex/SiO2/Si tri-layer system with ultrathin oxides. High-resolution transmission electron microscopy (HRTEM) and high-resolution X-ray diffraction rocking curves (HR-RC) and two-dimensional reciprocal space mapping (2D-RSM) were the main characterization tools. The poly-Si1-xGex/SiO2/Si structures have x=0, 0.2, and 0.35 for ultrathin oxides (2.0-3.0 nm). The result shows that for the adopted growth process, the poly grain size depends very strongly on the Ge concentration, and it increases with increasing Ge mole fraction. In turn, this increase of the grain size in the poly-Si1-xGex/SiO2/Si reduces the strain in the film, which then affects the interface strain at the lower SiO2/Si interface. In addition, the presence of defects at the SiO2/Si interface was found to be greater for samples with no local interface strain.

  • 99560.
    Ye, Rebecca
    et al.
    Stockholms Universitet, Stockholm, Sweden.
    Nylander, Erik
    Linköping University, Department of Behavioural Sciences and Learning, Education and Adult Learning. Linköping University, Faculty of Educational Sciences.
    The transnational track: State sponsorship and Singapore’s Oxbridge elite2015In: British Journal of Sociology of Education, ISSN 0142-5692, E-ISSN 1465-3346, Vol. 36, no 1, p. 11-33Article in journal (Refereed)
    Abstract [en]

    This paper explores the process of transnational institutional matching between elite institutions in Singapore and Great Britain, and the role of state-sponsored scholarships in enabling this process as political and administrative elites are selected and groomed. Using data gathered from in-depth interviews conducted with Singaporean undergraduates study- ing at Oxbridge and a dataset of the institutional origins of 580 Singap- orean government scholars, the analysis illustrates how students are being matched from two Singaporean junior colleges to Oxbridge and back to the higher strata of the Singaporean Public Service. We show that the educational trajectories of these government scholars need to be addressed in relation to the informational capital acquired in specific elite schools as well as the governing roles these individuals are meant to obtain within the state upon graduation.

  • 99561.
    Yeager, Austen
    Linköping University, Department of Culture and Communication, Centre for Applied Ethics.
    The Ethics of CRISPR: Using Human Germline Gene Modification to Prevent Genetic Disease2016Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    With the discovery and development of CRISPR, the technology that might allow us to modify the human germline is at our fingertips, and, consequently, serious practical and ethical consideration is warranted. In the following paper, I examine the ethics of using CRISPR in this way and argue that modifying the human germline for the purpose of preventing serious genetic disease is, in principle, ethically acceptable and ought to be allowed. I present several arguments to this effect including arguments that rely on the principles of beneficence and autonomy. I also examine the larger societal implications of human germline modification. I then respond to six of the most prominent objections that have been raised against CRISPR and germline gene modification before concluding with a brief discussion of the biggest challenge that we face as we move forward with CRISPR, that of limiting the use of this promising and incredibly versatile technology. 

  • 99562.
    Yeap, W. S.
    et al.
    Hasselt University, Belgium.
    Bevk, D.
    Hasselt University, Belgium; IMOMEC, Diepenbeek, Belgium .
    Liu, Xianjie
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
    Krysova, H.
    Academy of Sciences of The Czech Republic, Prague 8, Czech Republic .
    Pasquarelli, A.
    University of Ulm, Germany.
    Vanderzande, D.
    Hasselt University, Belgium; IMOMEC, Diepenbeek, Belgium .
    Lutsen, L.
    Hasselt University, Belgium; IMOMEC, Diepenbeek, Belgium .
    Kavan, L.
    Academy of Sciences of The Czech Republic, Prague 8, Czech Republic .
    Fahlman, Mats
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
    Maes, W.
    Hasselt University, Belgium; IMOMEC, Diepenbeek, Belgium .
    Haenen, K.
    Hasselt University, Belgium; IMOMEC, Diepenbeek, Belgium .
    Correction: Diamond functionalization with lighth-arvesting molecular wires: improved surface coverage by optimized Suzuki cross-coupling conditions (vol 4, pg 42044, 2014)2014In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, no 92, p. 50678-50678Article in journal (Other academic)
    Abstract [en]

    n/a

  • 99563.
    Yeap, W. S.
    et al.
    Hasselt University, Belgium .
    Bevk, D.
    Hasselt University, Belgium; IMEC vzw, IMOMEC, Diepenbeek, Belgium.
    Liu, Xianjie
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
    Krysova, H.
    J. Heyrovský Institute of Physical Chemistry, Prague, Czech Republic .
    Pasquarelli, A.
    University of Ulm, Germany.
    Vanderzande, D.
    Hasselt University, Belgium; IMEC vzw, IMOMEC, Diepenbeek, Belgium.
    Lutsen, L.
    Hasselt University, Belgium; IMEC vzw, IMOMEC, Diepenbeek, Belgium.
    Kavan, L.
    J. Heyrovský Institute of Physical Chemistry, Prague, Czech Republic .
    Fahlman, Mats
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
    Maes, W.
    Hasselt University, Belgium; IMEC vzw, IMOMEC, Diepenbeek, Belgium.
    Haenen, K.
    Hasselt University, Belgium; IMEC vzw, IMOMEC, Diepenbeek, Belgium.
    Diamond functionalization with light-harvesting molecular wires: improved surface coverage by optimized Suzuki cross-coupling conditions2014In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 4, no 79, p. 42044-42053Article in journal (Refereed)
    Abstract [en]

    Donor-acceptor type light-harvesting molecular wires are covalently attached to a boron-doped diamond surface via a combination of diazonium electrografting and Suzuki cross-coupling. For the Suzuki reaction, various catalytic systems are compared with respect to their imposed surface coverage. Combining 2-dicyclohexylphosphino-2,6-dimethoxybiphenyl (SPhos) and Pd(0), the diamond coverage improves considerably (by 98%) as compared to the standard tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)(4)) catalyst. As the energy levels between the molecular chromophores and the diamond film align well, the sophisticated functionalized diamond surfaces present a first step towards the development of fully carbon-based devices for light to electricity conversion.

  • 99564.
    Yeap, W.S.
    et al.
    Hasselt University, Diepenbeek, Belgium.
    Liu, X.
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
    Bevk, D.
    Hasselt University, Diepenbeek, Belgium.
    Pasquarelli, A.
    University of Ulm, Germany .
    Lutsen, L.
    IMEC VZW, Diepenbeek, Belgium.
    Fahlman, Mats
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry. Linköping University, The Institute of Technology.
    Maes, W.
    Hasselt University, Diepenbeek, Belgium.
    Haenen, K.
    Hasselt University, Diepenbeek, Belgium.
    Functionalization of boron-doped nanocrystalline diamond with N3 dye molecules2014In: ACS Applied Materials and Interfaces, ISSN 1944-8244, E-ISSN 1944-8252, Vol. 6, no 13, p. 10322-10329Article in journal (Refereed)
    Abstract [en]

    N3 dye molecules [cis-bis(isothiocyanato)bis(2,2-bipyridyl-4,4-dicarboxylato)ruthenium(II)] are covalently attached to boron-doped nanocrystalline diamond (B:NCD) thin films through a combination of coupling chemistries, i.e., diazonium, Suzuki, and EDC-NHS. X-ray and ultraviolet photoelectron spectroscopy and near-edge X-ray absorption fine structure spectroscopy are used to verify the covalent bonding of the dye on the B:NCD surface (compared to a hydrogen-terminated reference). The spectroscopic results confirm the presence of a dense N3 chromophore layer, and the positions of the frontier orbitals of the dye relative to the band edge of the B:NCD thin film are inferred as well. Proof-of-concept photoelectrochemical measurements show a strong increase in the photocurrent compared to non-dye-functionalized B:NCD films. This study opens up the possibility of applying N3-sensitized B:NCD thin films as hole conductors in dye-sensitized solar cells.

  • 99565.
    Yeganeh, Behzad
    et al.
    Department of Physiology, University of Manitoba, Winnipeg, Canada.
    Hashemi, Mohammad
    Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Iran.
    de Serres, Fredrick J.
    Center for Evaluation of Risks to Human Reproduction, National Institute of Environmental Health Sciences, Research Triangle Park, Iran.
    Los, Marek Jan
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Ghavami, Saeid
    University of Manitoba, Winnipeg, Canada.
    Different Faces of Hepatocellular Carcinoma as a Health Threat in 21st Century2013In: Hepatitis Monthly, ISSN 1735-143X, E-ISSN 1735-3408, Vol. 13, no 2Article in journal (Other academic)
  • 99566.
    Yeganeh, Behzad
    et al.
    University of Toronto, Toronto, Canada.
    Moghadam, Adel R
    Islamic Azad University, Ardabil, Iran.
    Alizadeh, Javad
    University of Manitoba, Winnipeg Canada.
    Wiechec, Emilia
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Alavian, Seyed M
    Baqiyatallah Research Center for Gastroenterology and Liver Disease, Tehran, Iran.
    Hashemi, Mohammad
    Zahedan University of Medical Sciences, Zahedan, Iran.
    Geramizadeh, Bita
    Shiraz University of Medical Sciences, Shiraz, Iran.
    Samali, Afshin
    National University of Ireland Galway, Galway, Ireland.
    Lankarani, Kamran B
    Shiraz University of Medical Sciences, Shiraz, Iran.
    Post, Martin
    University of Toronto, Toronto, Canada.
    Peymani, Payam
    Shiraz University of Medical Sciences, Shiraz, Iran.
    Coombs, Kevin M
    University of Manitoba, Winnipeg, Canada.
    Ghavami, Saeid
    University of Manitoba, Winnipeg, Canada.
    Hepatitis B and C virus-induced hepatitis: apoptosis, autophagy and unfolded protein response.2015In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 21, no 47, p. 13225-13239Article in journal (Refereed)
    Abstract [en]

    AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response (UPR) in hepatitis B (HBV) and C (HCV) infected hepatocytes.

    METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP (GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. Anti-HCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy (LC3β punctuate), apoptosis (cleaved caspase-3), and unfolded protein response (GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows (Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent non-infected cells.

    RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase (P < 0.001) in apoptosis (cleavage of caspase-3), autophagy (LC3β punctate), and UPR (increase in GRP78 expression) in the HCV- and HBV-infected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBVNeg and HBVPos revealed that majority of HBV-infected hepatocytes display strong positive staining for LC3β. Interestingly, although XBP splicing in HBV-infected cells was significantly higher (P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells (P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.

    CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue.

  • 99567.
    Yeganeh, Behzad
    et al.
    University of Toronto, Canada.
    Wiechec, Emilia
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences.
    Ande, Sudharsana R.
    University of Manitoba, Winnipeg, Canada.
    Sharma, Pawan
    University of Calgary, Alberta, Canada.
    Moghadam, Adel Rezaei
    Islamic Azad University, Tabriz, Iran.
    Post, Martin
    University of Toronto, Canada.
    Freed, Darren H.
    University of Manitoba, Winnipeg, Canada.
    Hashemi, Mohammad
    Zahedan University of Medical Sceinces, Iran.
    Shojaei, Shahla
    Shiraz University of Medical Sciences, Iran.
    Zeki, Amir A.
    U.C. Davis, School of Medicine, CA, USA.
    Ghavami, Saeid
    University of Manitoba, Winnipeg, Canada.
    Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease2014In: Pharmacology and Therapeutics, ISSN 0163-7258, E-ISSN 1879-016X, Vol. 143, no 1, p. 87-110Article, review/survey (Refereed)
    Abstract [en]

    The cholesterol biosynthesis pathway, also known as the mevalonate (MVA) pathway, is an essential cellular pathway that is involved in diverse cell functions. The enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR) is the rate-limiting step in cholesterol biosynthesis and catalyzes the conversion of HMG-CoA to MVA.

    Given its role in cholesterol and isoprenoid biosynthesis, the regulation of HMGCR has been intensely investigated. Because all cells require a steady supply of MVA, both the sterol (i.e. cholesterol) and non-sterol (i.e. isoprenoid) products of MVA metabolism exert coordinated feedback regulation on HMGCR through different mechanisms. The proper functioning of HMGCR as the proximal enzyme in the MVA pathway is essential under both normal physiologic conditions and in many diseases given its role in cell cycle pathways and cell proliferation, cholesterol biosynthesis and metabolism, cell cytoskeletal dynamics and stability, cell membrane structure and fluidity, mitochondrial function, proliferation, and cell fate.

    The blockbuster statin drugs (‘statins’) directly bind to and inhibit HMGCR, and their use for the past thirty years has revolutionized the treatment of hypercholesterolemia and cardiovascular diseases, in particular coronary heart disease. Initially thought to exert their effects through cholesterol reduction, recent evidence indicates that statins also have pleiotropic immunomodulatory properties independent of cholesterol lowering.

    In this review we will focus on the therapeutic applications and mechanisms involved in the MVA cascade including Rho GTPase and Rho kinase (ROCK) signaling, statin inhibition of HMGCR, geranylgeranyltransferase (GGTase) inhibition, and farnesyltransferase (FTase) inhibition in cardiovascular disease, pulmonary diseases (e.g. asthma and chronic obstructive pulmonary disease (COPD)), and cancer.

  • 99568.
    Yeknami, Ali Fazli
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    A 2.1 uW 76 dB SNDR DT-ΔΣ Modulator for Medical Implant Devices2012In: NORCHIP 2012, IEEE , 2012, p. 1-4Conference paper (Refereed)
    Abstract [en]

    This paper presents a low-power 2nd-order discrete-time (DT) ΔΣ analog-to-digital converter (ADC) aimed for medical implant devices. The designed ΔΣ modulator with two active integrators (filters) employs power-efficient two-stage load-compensated OTAs with minimal load and rail-to-rail output swing, which provides higher power-efficiency than the two-stage Miller OTA. The modulator, implemented in a 65nm CMOS technology with a core area of 0.033 mm2, achieves 76-dB peak SNDR over a 500 Hz signal bandwidth, while consuming 2.1 µW from a 0.9 V supply voltage. Compared to previously reported modulators for such signal bandwidths, the achieved performance (FOM of 0.4 pJ/step) make the presented modulator one of the best among sub-1-V modulators in term of most commonly used figure of merit.

  • 99569.
    Yeknami, Ali Fazli
    et al.
    School of Electrical Engineering and Computer Science, Oregon State University, Corvallis, OR, USA.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Integrated Circuits and Systems. Linköping University, Faculty of Science & Engineering.
    Low-Power Low-Voltage ΔΣ Modulator Using Switched-Capacitor Passive Filters.2015In: VLSI-SoC: At the Crossroads of Emerging Trends: 21st IFIP WG 10.5/IEEE International Conference on Very Large Scale Integration, VLSI-SoC 2013, Istanbul, Turkey, October 6-9, 2013, Revised Selected Papers / [ed] Alex Orailoglu, H. Fatih Ugurdag, Luís Miguel Silveira, Martin Margala and Ricardo Reis, Springer-Verlag New York, 2015, p. 94-118Chapter in book (Refereed)
    Abstract [en]

    A low-voltage low-power fourth-order active-passive ΔΣ modulator with one active stage is presented. The input-feedforward architecture is adopted, which improves the voltage swing prior to the quantizer. This enables a simpler comparator design and cascade of three passive filters. The passive integrator, as an alternate option to its power-hungry active counterpart, and the non-idealities associated with it are investigated. The active integrator used at the input stage provides most of the loop gain, which suppresses the thermal noise from the succeeding stages and minimizes the non-idealities in the comparator, such as noise and offset. The active integrator employs a two-stage amplifier with load compensation, whose DC-gain is boosted by a partially body-driven technique. The modulator, operated from a 0.7 V supply and clocked with 256 kHz sampling frequency, achieves 84 dB SNR and 80.3 dB SNDR over a 500 Hz signal bandwidth, while it dissipates only 400 nW power.

  • 99570.
    Yeknami, Ali Fazli
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Osgooei, Mostafa Savadi
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    A Programmable-Bandwidth Amplifier for Ultra-Low-Power Switched-Capacitor Application2011In: IEEE European Conference on Circuit Theory and Design (ECCTD), IEEE conference proceedings, 2011, p. 761-764Conference paper (Refereed)
    Abstract [en]

    This paper presents a novel approach to design a programmable-bandwidth amplifier intended for ultra-low-power switched-capacitor application. The proposed topology is based on the common load-compensated two-stage OTA. The GBW is enhanced by replicating the second amplifying stage. Implemented in a 65-nm CMOS technology and approved by the post-layout simulation, the GBW is programmed in three operation modes (400, 700, and 900 kHz), while 52-dB DC gain is preserved in a 5-pF load. The OTA consumes 275-nW static power in a 400 kHz unity-gain frequency and 375-nW static power in a 900 kHz unity-gain frequency from 0.9-V supply.

  • 99571.
    Yelhekar, Tushar D.
    et al.
    Umeå University, Sweden.
    Druzin, Michael
    Umeå University, Sweden.
    Karlsson, Urban
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Umeå University, Sweden.
    Blomqvist, Erii
    Umeå University, Sweden.
    Johansson, Staffan
    Umeå University, Sweden.
    How to Properly Measure a Current-Voltage Relation?: Interpolation vs. Ramp Methods Applied to Studies of GABA(A) Receptors2016In: Frontiers in Cellular Neuroscience, ISSN 1662-5102, E-ISSN 1662-5102, Vol. 10, no 10Article in journal (Refereed)
    Abstract [en]

    The relation between current and voltage, I-V relation, is central to functional analysis of membrane ion channels. A commonly used method, since the introduction of the voltage-clamp technique, to establish the I-V relation depends on the interpolation of current amplitudes recorded at different steady voltages. By a theoretical computational approach as well as by experimental recordings from GABA(A) receptor mediated currents in mammalian central neurons, we here show that this interpolation method may give reversal potentials and conductances that do not reflect the properties of the channels studied under conditions when ion flux may give rise to concentration changes. Therefore, changes in ion concentrations may remain undetected and conclusions on changes in conductance, such as during desensitization, may be mistaken. In contrast, an alternative experimental approach, using rapid voltage ramps, enable I-V relations that much better reflect the properties of the studied ion channels.

  • 99572. Yen, MA
    et al.
    Tabar, L
    Vitak, B
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiology. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology UHL.
    Smith, RA
    Chen, HH
    Duffy, SW
    Quantifying the potential problem of overdiagnosis of ductal carcinoma in situ in breast cancer screening2003In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 39, no 12, p. 1746-1754Article in journal (Refereed)
    Abstract [en]

    The relevance of detection of ductal carcinoma in situ (DCIS) in a breast cancer screening programme, and the extent of overdiagnosis of non-progressive lesions, remains controversial. It was the purpose of this paper to estimate the incidence of non-progressive, 'overdiagnosed' DCIS. We defined non-progressive DCIS (DCIS0) as DCIS which could not have progressed to invasive disease if left untreated. Progressive DCIS (DCIS1) was defined as DCIS which has the propensity to progress to invasive disease. We fitted a Markov process model of the incidence of progressive and non-progressive DCIS, the transition of the former to preclinical invasive disease and the subsequent progression to clinical symptomatic cancer. We used data from the Swedish Two-County Trial and from service screening programmes in the UK, Netherlands, Australia and the USA to estimate the incidence of progressive and non-progressive DCIS, and the detection rates of each at the first and subsequent screening. Average incidence of non-progressive DCIS was 1.11 per 100 000 per year. Average incidence of progressive DCIS was 2.1 per 1000 per year. At prevalence screen, 37% of DCIS cases were estimated to be non-progressive. A woman attending prevalence screen has a 19 times greater chance of having a progressive DCIS or an invasive tumour diagnosed than of having a non-progressive DCIS diagnosed. At incidence screen, only 4% of DCIS cases were estimated to be non-progressive. A woman attending an incidence screen has a 166 times higher probability of having a progressive DCIS or invasive lesion diagnosed than of having a non-progressive DCIS diagnosed. There is an element of overdiagnosis of DCIS in breast cancer screening, but the phenomenon is small in both relative and absolute terms. ⌐ 2003 Elsevier Ltd. All rights reserved.

  • 99573.
    Yeom, H. W.
    et al.
    Atomic-scale Surface Science Research Center and Institute of Physics and Applied Physics, Yonsei University, bKorea.
    Horikoshi, K
    Department of Physics, The University of Tokyo, Japan.
    Zhang, Hanmin
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Ono, K
    Department of Applied Chemistry, The University of Tokyo, Japan .
    Uhrberg, Roger
    Linköping University, Department of Physics, Chemistry and Biology, Surface and Semiconductor Physics. Linköping University, The Institute of Technology.
    Nature of the broken-symmetry phase of the one-dimensional metallic In/Si(111) surface2002In: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 65, no 24Article in journal (Refereed)
    Abstract [en]

    The phase transition of a metallic In chain structure on Si(111) was investigated by high-resolution photoemission. Core-level spectra clearly elucidate that the symmetry breaking at low temperature occurs only within the inner parts of the In chains. In the valence bands, the transition is accompanied by the formation of pseudogaps of 80–150 meV and the band backfolding with only marginal changes of the band dispersion. No sign of Luttinger liquid behavior is observed in the spectral function near the Fermi level. This result is generally consistent with the idea of a fluctuating one-dimensional charge-density wave state but conflicting with the present structure model for the low-temperature phase.

  • 99574.
    Yeom, HW
    et al.
    Department of Applied Chemistry, University of Tokyo, Japan.
    Matsuda, I
    Department of Chemistry, University of Tokyo, Japan.
    Chao, Y.-C.
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Hara, S
    Electrotechnical Laboratory, Tsukuba, Japan.
    Yoshida, S
    Electrotechnical Laboratory, Tsukuba, Japan.
    Uhrberg, Roger
    Linköping University, Department of Physics, Chemistry and Biology, Surface and Semiconductor Physics. Linköping University, The Institute of Technology.
    Hydrogen-induced 3×1 phase of the Si-rich 3C-SiC(001) surface2000In: Physical Review B. Condensed Matter and Materials Physics, ISSN 1098-0121, E-ISSN 1550-235X, Vol. 61, no 4, p. R2417-R2420Article in journal (Refereed)
    Abstract [en]

    A single-domain 3×1 phase induced by hydrogen adsorption on a Si-rich 3C-SiC(001)3×2 surface is investigated by photoemission using synchrotron radiation. Three surface components of the Si 2p core level are identified for the 3×1-H phase, which resemble those of the 3×2 surface. A H-Si bonding state is observed by angle-resolved valence-band photoemission. These results are consistent with the recent assignments of the Si 2p surface components and the valence band spectra of the 3×2 surface, based on the 3×2 structure model with 2/3 ML Si addimers. A straightforward 3×1-H structure model is introduced featuring Si dimer-bond breaking and dangling-bond saturation.

  • 99575.
    Yeom, HW
    et al.
    Yonsei Univ, Atom Scale Surface Sci Res Ctr, Seoul 120749, South Korea Yonsei Univ, Inst Phys & Appl Phys, Seoul 120749, South Korea Linkoping Univ, Dept Phys & Measurement Technol, S-58183 Linkoping, Sweden.
    Uhrberg, Roger
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Surface and Semiconductor Physics .
    High resolution photoemission study of low-temperature oxidation on the Si(001) surface2000In: Japanese Journal of Applied Physics, ISSN 0021-4922, E-ISSN 1347-4065, Vol. 39, no 7B, p. 4460-4463Article in journal (Refereed)
    Abstract [en]

    High-resolution photoemission is applied to the oxygen adsorption on the Si(001) surface at 120 K and the subsequent evolution of the adsorbates upon annealing. Si 2p components due to the Si2+ and Si3+ species are observed from the very early stage of adsorption at similar to 120 K, which grow linearly with the oxygen coverage. This indicates an active agglomeration of oxygen adsorbates even for the submonolayer adsorption at low temperature. Annealing above 500 K enhances the agglomeration by mostly converting the Si1+ species into Si3+ and then into Si4+. In addition, the annealing changes the Si 2p binding energies for the Si2+ and Si3+ species by 0.14 and 0.23 eV, respectively. These shifts are attributed to the structural relaxation (strain relief) of the metastable oxygen-adsorbate complex formed at low temperature.

  • 99576.
    Yeomans, N
    et al.
    Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
    Wilson, I
    Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
    Langstrom, G
    Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
    Hawkey, C
    Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
    Naesdal, J
    Univ Melbourne, Western Hosp, Dept Med, Footscray, Vic 3011, Australia AstraZeneca R&D Molndal, Molndal, Sweden Univ Nottingham Hosp, Div Gastroenterol, Nottingham NG7 2UH, England Linkoping Univ, Dept Biomed & Surg, S-58183 Linkoping, Sweden Linkoping Univ, Dept Internal Med, S-58183 Linkoping, Sweden Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway.
    Walan, A
    Wiklund, I
    Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol2001In: Scandinavian Journal of Rheumatology, ISSN 0300-9742, E-ISSN 1502-7732, Vol. 30, no 6, p. 328-334Article in journal (Refereed)
    Abstract [en]

    Objective: To compare the impact on quality of life (QoL) of omeprazole and misoprostol during healing, and omeprazole, misoprostol, and placebo during maintenance treatment in chronic NSAID users with NSAID-associated gastroduodenal lesions. Methods: Validated baseline and follow-up QoL questionnaires were completed by 610 patients (healing: after 4.8 weeks: maintenance: after 6 months). Results: Patients with arthritis being treated with NSAIDs have a poor QoL. Rheumatoid arthritis causes more joint problem. and physical mobility limitations than osteoarthritis. Chronic NSAID use causes heartburn and dyspepsia. QoL improved on both treatments (about equally on two general QOL scales), but omeprazole relieved gastrointestinal symptoms more than misoprostol, particularly reflux. abdominal pain and indigestion symptoms, During maintenance, both treatments maintained QoL, but misoprostol induced diarrhoea, Conclusion: QoL in arthritis patient, on chronic NSAID treatment is destroyed. Omeprazole is superior to misoprostol for relief and prevention of NSAID-associated gastrointestinal symptoms allowing continued NSAID treatment without compromising the patients' QoL.

  • 99577.
    Yesmin Shova, Tahmina
    Linköping University, Department of Culture and Communication.
    Liberal Citizenship in a Multicultural Society: Brian Barry's and William Galston's Approaches to Citizenship2017Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This thesis demonstrates a comparative and analytic discussion of citizenship idea based on two distinct liberal doctrines of two contemporary political philosophers: Brian Barry and William Galston. Barry's egalitarian liberalism argues for 'common citizenship' notion in order to promote liberty and equal treatment of all individuals irrespective of any social differences. On the other hand, 'liberal pluralist citizenship' of William Galston's signifies his liberal pluralism to mitigate cultural and religious conflicts of liberal democratic society. The fundamental disagreements among these liberal approaches over the issues of public recognition of group rights and restricted state authority are analysed in this study. Finally, by analysing both the liberal positions under the challenge of multicultural issues the author defends Galston's liberal idea and judges it as more convincing than Barry's liberal approach.

  • 99578.
    Yeung, Sing Yee
    et al.
    Malmo Univ, Sweden; Malmo Univ, Sweden.
    Ederth, Thomas
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Physics. Linköping University, Faculty of Science & Engineering.
    Pan, Guoqing
    Malmö Univ, Sweden.
    Cicenaite, Judita
    Malmö Univ, Sweden.
    Cardenas, Marite
    Malmö Univ, Sweden.
    Arnebrant, Thomas
    Malmö Univ, Swedenn.
    Sellergren, Borje
    Malmö Univ, Sweden.
    Reversible Self-Assembled Monolayers (rSAMs) as Robust and Fluidic Lipid Bilayer Mimics2018In: Langmuir, ISSN 0743-7463, E-ISSN 1520-5827, Vol. 34, no 13, p. 4107-4115Article in journal (Refereed)
    Abstract [en]

    Lipid bilayers, forming the outer barrier of cells, display a wide array of proteins and carbohydrates for modulating interfacial biological interactions. Formed by the spontaneous self-assembly of lipid molecules, these bilayers feature liquid crystalline order, while retaining a high degree of lateral mobility. Studies of these dynamic phenomena have been hampered by the fragility and instability of corresponding biomimetic cell membrane models. Here, we present the construct of a series of oligoethylene glycol-terminated reversible self-assembled monolayers (rSAMs) featuring lipid-bilayer-like fluidity, while retaining air and protein stability and resistance. These robust and ordered layers were prepared by simply immersing a carboxylic acid terminated self-assembled monolayer into 5-50 mu M aqueous omega-(4-ethylene glycol-phenoxy)-alpha-(4-amidinophenoxy)decane solutions. It is anticipated that this new class of robust and fluidic two-dimensional biomimetic surfaces will impact the design of rugged cell surface mimics and high-performance biosensors.

  • 99579.
    Ygge, Nicklas
    et al.
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Hagberg, Robin
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Kontroll eller fria tyglar?: En fallstudie om organisationskontroll inom konsultbranschen ur ett organisatoriskt perspektiv2018Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Background: Since the development of business economics has shifted from an industrial society to a knowledge society, external expertise is demanded from knowledge-intensive companies. Many consulting firms are good examples of the post- bureaucratic organization, characterized by relatively few layers of hierarchy, flexibility, decision-making involvement and loose career structures, where the identity becomes difficult to operate. Identity is of particular importance when it comes to KIFs for different reasons. It is becoming increasingly prominent for leaders to try to shape the individuals themselves. It is important for management to influence employees through strategies to achieve organizational control, ensure loyalty and prevent existential uncertainty as well as create self-confidence and self-esteem at work.

    Purpose: The purpose of the study is to provide, with the help of existing theories and empirical evidence, an increased understanding of how KIFs use identity regulation to obtain organizational control.

    Empiric: The study has been conducted with a qualitative method through a case study design through interviews with employees in relevant companies in the consulting industry. Respondents have had varying positions and skills in their respective companies.

    Result: The result of this study shows that knowledge-intensive companies work with organizational control where identity plays a central role. Several strategies are presented such as recruitment, value offerings, educations, scaled-down hierarchy, social activities, teams, corporate storytelling and values, which helps to understand how KIFs work with identity regulation to achieve organizational control.

  • 99580.
    Yi, Choong-ho
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    Modelling object-oriented dynamic systems using a logic-based framework2002Doctoral thesis, monograph (Other academic)
    Abstract [en]

    We observe that object-oriented (OO) formalisms and specification languages are popular and obviously useful, and, in particular, that they are increasingly used even for systems that change over time. At the same time, however, the system specification is not precise enough in these approaches. This thesis presents a formal approach to modelling OO dynamic systems using a logic-based framework. The UML which is an OO standard language, and the Statecharts formalism which is a leading approach to modelling dynamic systems, have been formalized in the framework. In addition, formal reasoning from the system-in-run perspective has been put forward, focusing on business goals. Business goals, an emerging issue within systems engineering, are reasoned with as a systematic way to check whether the goals are achieved or not in real business activities, and to cope with the situation where the goals are violated. 

  • 99581.
    Yi, Jewel
    et al.
    Curtin University, Australia.
    Chung-Yeung Lee, Hoe
    Curtin University, Australia.
    Parsons, Richard
    Curtin University, Australia.
    Falkmer, Torbjörn
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Curtin University, Australia; La Trobe University, Australia.
    The Effect of the Global Positioning System on the Driving Performance of People with Mild Alzheimers Disease2015In: Gerontology, ISSN 0304-324X, E-ISSN 1423-0003, Vol. 61, no 1, p. 79-88Article in journal (Refereed)
    Abstract [en]

    Introduction: The initial symptoms of Alzheimers disease (AD) include attention deficits, memory loss and deficiencies in topographic and spatial orientation. People with AD may have way-finding difficulties in driving due to the deterioration of their navigation ability. Although the use of the Global Positioning System (GPS) has been proven to be a useful aid for older people in driving, there is no evidence to suggest that the benefit could extend to drivers with AD. Aim: This study aims to investigate the effectiveness of the GPS in assisting drivers with mild AD in finding their destination safely. Method: Twenty-eight drivers with mild to very mild AD, diagnosed by a general practitioner or a psychogeriatrician, completed all clinical and psychometric assessments including the Mini Mental State Examination, Trail Making Test B and Doors and People Test. During the driving assessment, 3 driving trials with different settings (normal, visualonly and audio-only) of the GPS were administered to all participants. The participants were required to follow instructions from the GPS and perform a variety of driving tasks on a driving simulator. The driving performances of participants were assessed by criteria specific to AD drivers. The driving assessment criteria were first combined to form the overall driving performance score: a higher score indicated a better overall driving performance. The other outcome of this study was the success of participants to navigate to a predetermined destination. Results: The driving performance of participants was different among the 3 settings (F = 72.8, p less than 0.001) and the pairwise comparison between the 3 settings was significant (p less than 0.001). The driving performance score was highest in the audio-only setting (mean: 20.0, SD: 2.2), moderate in the normal setting (mean: 16.7, SD: 2.6) and lowest in the visual-only setting (mean: 14.3, SD: 3.3). When compared with the visual-only setting, drivers using the audioonly setting (OR: 37.2, 95% CI: 9.2-151.2) and normal setting (OR: 37.2, 95% CI: 4.8-286.9) were more likely to successfully find their destination (p less than 0.05). Conclusion: This study has found that using single, simple auditory instructions with the absence of the visual output of the GPS could potentially help people with mild AD to improve their driving ability and reach their destination.

  • 99582.
    Yi, Qian
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Vehicle Ownership and Fleet models2011Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Vehicle ownership model is an important tool in finding tax strategies as well as reducing the pollution effects based on the forecast results from the model. However, the limitations and shortcomings of the existing vehicle ownership models lead to the low quality forecast in some aspects.

    Therefore, the thesis surveys the vehicle ownership models as well as vehicle fleet models. The research is mainly about the car ownership and fleet model. The currently used car ownership models in Europe are listed and four models are introduced briefly, including their advantages and disadvantages. The relationship between vehicle ownership and fleet models are also described.

    One specific car ownership model is used for numerical test. The tested car ownership model is the sub-model in Sampers’ in Sweden. This model consists of individual entry and exit probability of car ownership. The estimation data is the same as the data used in Matstoms (2002), which includes the information of the number of cars for different age, gender, income level, and the petrol price, GDP, from 1980 to 1995 in Stockholm, Solna and Sundbyberg. The software used for model estimation is SPSS.

    The following part is to validate the estimation results and find out the sensitivity of each variable by doing forecasting in Stockholm from 1996 to 2010. The sensitivity analysis shows that the car ownership in Stockholm is most sensitive to petrol price and least sensitive to GDP. We recommend removing the GDP variable and test it by using chi-square test. The chi-square test shows that the GDP variable can be removed from the model.

    Keyword Vehicle ownership, Vehicle fleet, Car ownership, SPSS, Sampers, Nonlinear regression analysis.

  • 99583.
    Yi, Wu
    et al.
    ST Ericsson, Sweden .
    Meng, Zheng
    Beijing Institute Technology, Peoples R China .
    ZeSong, Fei
    Beijing Institute Technology, Peoples R China .
    Larsson, Erik G
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, The Institute of Technology.
    JingMing, Kuang
    Beijing Institute Technology, Peoples R China .
    Outage probability analysis for superposition coded symmetric relaying2013In: SCIENCE CHINA-INFORMATION SCIENCES, ISSN 1674-733X, Vol. 56, no 2Article in journal (Refereed)
    Abstract [en]

    Superposition coded symmetric relaying is a bandwidth-efficient cooperative scheme where each source node simultaneously transmits both its own "local" packet and "relay" packet that originated at its partner by adding the modulated local and relay signals in Euclidean space. This paper investigates the power allocation and outage probability of a superposition coded symmetric relaying system with finite-constellation signaling. We first derive the mutual information (MI) metrics for the system. The derived MI metrics consist of two parts: one represents the MI conveyed by the modulated signal corresponding to its own data, and the other represents the MI conveyed by the modulated signal corresponding to its partners data. Using MI based effective signal-to-noise ratio mapping technique, we attain expressions for the outage probability. Furthermore, we discuss power allocation policies that minimize the outage probability. Simulation results are presented to verify the correctness of the outage probability analysis and the benefits of the power allocation.

  • 99584.
    Yi, Zhao
    Linköping University, Department of Management and Engineering, Machine Design .
    Developing a wafer with customer amenity—an application of Kansei engineering2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    New food product development is so often confronted with failure in the market. One of the significant reasons is, nowadays, the customer preference is no longer simply only determined by a few factors rather a combination of various needs. This article presents an affective engineering methodology “Kansei Engineering” which can tailor the product by the customer need. This methodology is able to assist the food product developer to connect the consumer affection with the product properties in order to develop the food product with the most affective influence deep in customer’s mind associated with product. Using this systematic affective methodology “Kansei engineering” approach would help the company to develop the food with consumer amenity.

  • 99585.
    Yien Tan, Hong
    et al.
    University of Malaya, Malaysia.
    Kong Yong, Yean
    University of Malaya, Malaysia.
    Shankar, Esaki M.
    University of Malaya, Malaysia; University of Malaya, Malaysia.
    Paukovics, Geza
    Macfarlane Burnet Institute Medical Research and Public Heatlh, Australia.
    Ellegård, Rada
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Larsson, Marie
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Kamarulzaman, Adeeba
    University of Malaya, Malaysia.
    French, Martyn A.
    University of Western Australia, Australia; Royal Perth Hospital, Australia.
    Crowe, Suzanne M.
    Macfarlane Burnet Institute Medical Research and Public Heatlh, Australia; Alfred Hospital, Australia; Monash University, Australia.
    Aberrant Inflammasome Activation Characterizes Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome2016In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 196, no 10, p. 4052-4063Article in journal (Refereed)
    Abstract [en]

    Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) complicates combination antiretroviral therapy (cART) in up to 25% of patients with HIV/TB coinfection. Monocytes and IL-18, a signature cytokine of inflammasome activation, are implicated in TB-IRIS pathogenesis. In this study, we investigated inflammasome activation both pre- and post-cART in TB-IRIS patients. HIV/TB patients exhibited higher proportions of monocytes expressing activated caspase-1 (casp1) pre-cART, compared with HIV patients without TB, and patients who developed TB-IRIS exhibited the greatest increase in casp1 expression. CD64(+) monocytes were a marker of increased casp1 expression. Furthermore, IL-1 beta, another marker of inflammasome activation, was also elevated during TB-IRIS. TB-IRIS patients also exhibited greater upregulation of NLRP3 and AIM2 inflammasome mRNA, compared with controls. Analysis of plasma mitochondrial DNA levels showed that TB-IRIS patients experienced greater cell death, especially pre-cART. Plasma NO levels were lower both pre- and post-cART in TB-IRIS patients, providing evidence of inadequate inflammasome regulation. Plasma IL-18 levels pre-cART correlated inversely with NO levels but positively with monocyte casp1 expression and mitochondrial DNA levels, and expression of IL-18R alpha on CD4(+) T cells and NK cells was higher in TB-IRIS patients, providing evidence that IL-18 is a marker of inflammasome activation. We propose that inflammasome activation in monocytes/macrophages of HIV/TB patients increases with ineffective T cell-dependent activation of monocytes/macrophages, priming them for an excessive inflammatory response after cART is commenced, which is greatest in patients with TB-IRIS.

  • 99586.
    Yildiz, George
    et al.
    Linköping University, Department of Computer and Information Science.
    Iselius, Fredrik
    Linköping University, Department of Computer and Information Science.
    Lundgren, Patrik
    Linköping University, Department of Computer and Information Science.
    Persson, Henrik
    Linköping University, Department of Computer and Information Science.
    Persson Proos, Daniel
    Linköping University, Department of Computer and Information Science.
    Sörliden, Pär
    Linköping University, Department of Computer and Information Science.
    Nilsson, Kristian
    Linköping University, Department of Computer and Information Science.
    Analysera stora mängder video och bildmaterial2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 99587.
    Yildiz, George
    et al.
    Linköping University, Department of Computer and Information Science, Software and Systems.
    Wallström, Fredrik
    Linköping University, Department of Computer and Information Science, Software and Systems.
    Evaluation of Couchbase As a Tool to Solve a Scalability Problem with Shared Geographical Objects2019Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Sharing a large amount of data between many mobile devices can lead to scalability problems. One of these scalability problems is that the data becomes too large to store on mobile devices and that many updates are sent to each device. In this thesis, Couchbase is evaluated as a tool to solve this problem where the data has a geographical position. The scalability problem is solved by partitioning the data with the help of Couchbase channels and Google’s tile-based mapping system. Synchronising and storing only data of interest for each user has been in focus. The result showed that it was effective to use a Couchbase solution together with Google’s tile-based mapping system to reduce the amount of data that was required to be stored for each user. It was shown to be more effective to store objects encoded as base64 data instead of their binary data representation for the data set used in this study. The reason for this is because Couchbase stores Binary Large Objects (BLOBs) as separate files and the BLOBs in the data set had much smaller file size than what the disk sector size was. A test to find how the synchronisation time was affected by the number of channels was conducted. It showed that the synchronisation time increased linearly with an increasing number of channels when the objects were stored in separate files. When the objects were encoded as base64 data, the number of channels used had a minor effect on the synchronisation time. The conclusion is that the approach presented in this study has been effective. However, the results are data dependent and therefore it is recommended to rerun similar tests in order to decide the number of channels to use when partitioning the data.

  • 99588.
    Yildiz, Sema
    Linköping University, Department of Culture and Communication.
    Preparatory Ethics University prior to Participatory Technology Assessment (PEUPTA): A New Approach to Public Engagement in Science and Technology2016Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    This paper provides a new approach to public engagement in science and technology. The work derives from the idea to recall the necessity of a paradigm shift for not only agent-focused, but also agent-centered as well interactive-deliberative engagement mechanisms with low or high policy relevancy. For this purpose, an evaluative synthesis is presented, aimed to offer the modern concept of the Ethics University as a preparatory element prior to the traditional Participatory Technology Assessment. The primary aim of a Preparatory Ethics University, in the form of a seminar with learning stations, would be to supplement and support existing participatory mechanisms. But also it would lay ground for new designs in public engagement processes. This interlinked concept shall increase effectiveness of public engagement and deliberation for decision-making purposes. Being informed about ethical matters in educative and reflective dialogues can be a fruitful pre-step to a well-informed decision during an important Technology Assessment. In this interdisciplinary work, I will first justify why public participation and deliberation was necessary and then present the understanding of public participation in science and technology. Second, I will present relevant public engagement concepts, as previously mentioned, and interlink them to point out combined strengths and benefits from a Preparatory Ethics University. Third, I will open a discussion about the challenges each concept poses, objections that might occur towards a Preparatory Ethics University prior to Participatory Technology Assessment, and the accompanying answers to those. I will conclude that this new approach creates substantive opinions, empowers, educates, and deliberates on complex and controversial issues while increasing reasonable decision-making. Thus, this new approach can be considered as a new type of public engagement in the field of science and technology.

  • 99589.
    Yilmaz, Erkut
    et al.
    Aksaray University, Turkey.
    Garipcan, Bora
    Bogazici University, Turkey.
    Patra, Hirak Kumar
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences.
    Uzun, Lokman
    Hacettepe University, Turkey.
    Molecular Imprinting Applications in Forensic Science2017In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 17, no 4, article id 691Article, review/survey (Refereed)
    Abstract [en]

    Producing molecular imprinting-based materials has received increasing attention due to recognition selectivity, stability, cast effectiveness, and ease of production in various forms for a wide range of applications. The molecular imprinting technique has a variety of applications in the areas of the food industry, environmental monitoring, and medicine for diverse purposes like sample pretreatment, sensing, and separation/purification. A versatile usage, stability and recognition capabilities also make them perfect candidates for use in forensic sciences. Forensic science is a demanding area and there is a growing interest in molecularly imprinted polymers (MIPs) in this field. In this review, recent molecular imprinting applications in the related areas of forensic sciences are discussed while considering the literature of last two decades. Not only direct forensic applications but also studies of possible forensic value were taken into account like illicit drugs, banned sport drugs, effective toxins and chemical warfare agents in a review of over 100 articles. The literature was classified according to targets, material shapes, production strategies, detection method, and instrumentation. We aimed to summarize the current applications of MIPs in forensic science and put forth a projection of their potential uses as promising alternatives for benchmark competitors.

  • 99590.
    Yilmaz, Feyzullah
    Linköping University, Department of Management and Engineering.
    The United Nations Security Council Reform: A Critical Approach2007Independent thesis Advanced level (degree of Magister), 20 points / 30 hpStudent thesis
    Abstract [en]

    Utilizing Critical Theory, through its neo-Gramscian and Frankfurt School dimensions, as the theoretical framework, this study aims to explain how the institutions, such as the United Nations, of an international system transform together with the structure – the international system. More specifically our aim is to explain the lack of transformation of only one body, the Security Council, of that specific institution, the United Nations.

    Analyzing the press releases of the United Nations General Assembly in 1996, 1997, 2000, and 2006 and examining 337 statements from the Member States through Critical Theory to be able understand and explain how and why it hasn’t been possible to reform, or transform, the United Nations Security Council in the last 14 years since the establishment of the Open-Ended Working Group as a group to particularly deal with the question of reform. The analysis suggests that the current debates in the United Nations concerning the reform of the Security Council is unable to produce a successful transformation of that body because it is not possible for an institution to finalize its own transformation independent from that of the structure as a whole.

  • 99591.
    Yim, Keng-Hoong
    et al.
    University of Cambridge.
    Doherty, Walter J
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Salaneck, William R
    Linköping University, Department of Physics, Chemistry and Biology, Surface Physics and Chemistry . Linköping University, The Institute of Technology.
    Murphy, Craig E
    National Physics Lab, Teddington .
    Friend, Richard H
    University of Cambridge.
    Kim, Ji-Seon
    University London Imperial College of Science and Technology and Medicine.
    Phase-Separated Thin Film Structures for Efficient Polymer Blend Light-Emitting Diodes2010In: NANO LETTERS, ISSN 1530-6984, Vol. 10, no 2, p. 385-392Article in journal (Refereed)
    Abstract [en]

    We report laterally and vertically phase-separated thin film structures in conjugated polymer blends created by polymer molecular weight variation. We find that micrometer-scale lateral phase separation is critical in achieving high initial device efficiency of light-emitting diodes, whereas improved balance of charge carrier mobilities and film thickness uniformity are important in maintaining high efficiency at high voltages. The optoelectronic properties of these blend thin films and devices are strongly influenced by the polymer chain order/disorder and the interface state formed at polymer/polymer heterojunctions.

  • 99592.
    Yimamu (Imam), Maiwulidan (Mewlude)
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, Faculty of Science & Engineering.
    Chemical vapour deposition of boron-carbon thin films from organoboron precursors2015Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    Boron-carbon (BxC) thin films enriched in 10B are potential neutron converting layers for 10Bbased solid-state neutron detectors given the good neutron absorption cross-section of 10B atoms in the thin film. Chemical Vapour Deposition (CVD) of such films faces the challenge that the maximum temperature tolerated by the aluminium substrate is 660 °C and low temperature CVD routes for BxC films are thus needed. This thesis presents the use of two different organoboron precursors, triethylboron –B(C2H5)3 (TEB) and trimethylboron – B(CH3)3 (TMB) as single-source precursors for CVD of BxC thin films.

    The CVD behaviour of TEB in thermal CVD has been studied by both BxC thin film deposition and quantum chemical calculations of the gas phase chemistry at the corresponding CVD conditions. The calculations predict that the gas phase reactions are dominated by β-hydride eliminations of C2H4 to yield BH3. In addition, a complementary bimolecular reaction path based on H2-assisted C2H6 elimination to BH3 is also present at lower temperatures in the presence of hydrogen molecules. A temperature window of 600 – 1000 °C for deposition of X-ray amorphous BxC films with 2.5 ≤ x ≤ 4.5 is identified showing good film density (2.40 – 2.65 g/cm3) which is close to the bulk density of crystalline B4C, 2.52 g/cm3 and high hardness (29 – 39 GPa). The impurity level of H is lowered to < 1 at. % within the temperature window.

    Plasma chemical vapour deposition has been studied using TMB as single-source precursor in Ar plasma for investigating BxC thin film deposition at lower temperature than allowed by thermal CVD and further understanding of thin film deposition process. The effect of plasma power, total pressure, TMB and Ar gas flow on film composition and morphology are investigated. The highest B/C ratio of 1.9 is obtained at highest plasma power of 2400 W and TMB flow of 7 sccm. The H content in the films seems constant at 15±5 at. %. The B-C bond is dominant in the films with small amount of C-C and B-O bonds, which are likely due to the formation of amorphous carbon and surface oxidation, respectively. The film density is determined as 2.16±0.01 g/cm3 and the internal compressive stresses are measured to be <400 MPa.

    List of papers
    1. Gas phase chemical vapor deposition chemistry of triethylboron probed by boron-carbon thin film deposition and quantum chemical calculations
    Open this publication in new window or tab >>Gas phase chemical vapor deposition chemistry of triethylboron probed by boron-carbon thin film deposition and quantum chemical calculations
    Show others...
    2015 (English)In: Journal of Materials Chemistry C, ISSN 2050-7526, E-ISSN 2050-7534, Vol. 3, no 41, p. 10898-10906Article in journal (Refereed) Published
    Abstract [en]

    We present triethylboron (TEB) as a single-source precursor for chemical vapor deposition (CVD) of BxC thin films and study its gas phase chemistry under CVD conditions by quantum chemical calculations. A comprehensive thermochemical catalogue for the species of the gas phase chemistry of TEB is examined and found to be dominated by beta-hydride eliminations of C2H4 to yield BH3. A complementary bimolecular reaction path based on H-2 assisted C2H6 elimination to BH3 is also significant at lower temperatures in the presence of hydrogen. Furthermore, we find a temperature window of 600-1000 degrees C for the deposition of X-ray amorphous BxC films with 2.5 less than= x less than= 4.5 from TEB. Films grown at temperatures below 600 degrees C contain high amounts of H, while temperatures above 1000 degrees C result in C-rich films. The film density and hardness are determined to be in the range of 2.40-2.65 g cm(-3) and 29-39 GPa, respectively, within the determined temperature window.

    Place, publisher, year, edition, pages
    ROYAL SOC CHEMISTRY, 2015
    National Category
    Physical Sciences Chemical Sciences
    Identifiers
    urn:nbn:se:liu:diva-122673 (URN)10.1039/c5tc02293b (DOI)000363252200030 ()
    Note

    Funding Agencies|European Spallation Source ESS AB; Knut and Alice Wallenberg Foundation; German Science Foundation (Research Training Group 1782); Beilstein Foundation (Frankfurt/Germany)

    Available from: 2015-11-16 Created: 2015-11-13 Last updated: 2017-09-29
    2. Trimethylboron as single-source precursor for boron-carbonthin film synthesis by plasma chemical vapor deposition
    Open this publication in new window or tab >>Trimethylboron as single-source precursor for boron-carbonthin film synthesis by plasma chemical vapor deposition
    Show others...
    2015 (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Boron-carbon (BxC) thin films are potential neutron converting layers for 10B-based neutron detectors. However, as common material choices for such detectors do not tolerate temperature above 500°C, a low temperature deposition route is required for this application. Here we study trimethylboron B(CH3)3 (TMB) as a single-source precursor for the deposition of BxC thin films by plasma CVD using Ar plasma. The effect of plasma power, TMB/Ar ratio and total pressure on the film composition, morphology and structure are investigated. The highest B/C ratio of 1.9 was achieved at high TMB flow in a low total pressure and high plasma power which rendered an approximate substrate temperature of ~ 300 °C. X-ray photoelectron spectroscopy shows that B-C bonds prevail in the films, although C-C and B-O bonds are also present. Raman spectroscopy confirms the presence of amorphous carbon phases in the films. The H content in the films is found to be 15±5 at. % by the time of flight elastic recoil detection analysis (Tof-ERDA). The film density as determined from X-ray reflectivity (XRR) measurements is 2. 16 ± 0.01  g/cm3 and the internal compressive stresses are measured to be less than 400 MPa.

    National Category
    Physical Sciences Chemical Sciences
    Identifiers
    urn:nbn:se:liu:diva-123908 (URN)
    Available from: 2016-01-13 Created: 2016-01-13 Last updated: 2016-01-13Bibliographically approved
  • 99593.
    Yin, Bin
    et al.
    Tianjin University of Technology.
    Yang, Liying
    Tianjin University of Technology.
    Liu, Yongsheng
    Nankai University.
    Chen, Yongsheng
    Nankai University.
    Qi, Qingjin
    Tianjin University of Technology.
    Zhang, Fengling
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics . Linköping University, The Institute of Technology.
    Yin, Shougen
    Tianjin University of Technology.
    Solution-processed bulk heterojunction organic solar cells based on an oligothiophene derivative2010In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 97, no 2, p. 023303-Article in journal (Refereed)
    Abstract [en]

    Organic bulk heterojunction (BHJ) solar cells based on a dicyanovinyl-substituted oligothiophene as a donor and [6,6]-phenyl C61 butyric acid methyl ester (PCBM) as an acceptor were fabricated and characterized. The oligothiophene derivative can absorb long wavelength photons of the solar radiation, which makes the solar cells with an optimized weight ratio of 1:1.4 have a decent short-circuit current density (12.4 mA/cm(2)) and open-circuit voltage (0.88 V) under AM 1.5G illumination with an intensity of 100 mW/cm(2). A power conversion efficiency (PCE) of 3.7% is achieved, which is among the best PCEs of solution processed small molecule BHJ solar cells.

  • 99594.
    Yin, D
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Pathology.
    Is carbonyl detoxification an important anti-aging process during sleep?2000In: Medical Hypotheses, ISSN 0306-9877, E-ISSN 1532-2777, Vol. 54, no 4, p. 519-522Article in journal (Refereed)
    Abstract [en]

    Organisms living on the earth may undergo inevitable toxification by biological 'garbage', a variety of biometabolites. Such garbage includes a particularly large number of toxic carbonyls, such as a,▀-unsaturated carbonyls created by free radicals, glycation, and other post-translational side-reactions during various stresses and diseases. The accumulation of these toxic substances and their crosslinking products leads to the formation of different age pigments, such as lipofuscin, lens cataracts, and crosslinked collagen. The diurnal fluctuation in the concentration of the pineal gland hormone, melatonin, may be responsible for the 'cleaning activities' that reverse the covalently-bound semi-toxified proteins and nucleic acids. This toxification-cleaning cycle may explain the biochemical necessity for sleep of human and animals during aging. (C) 2000 Harcourt Publishers Ltd.

  • 99595.
    Yin, Dazhong
    Linköping University, Department of Neuroscience and Locomotion, Pathology. Linköping University, Faculty of Health Sciences.
    Age pigments and the biochemical basis of their formation1995Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The autofluorescent, yellow-brown pigments that accumulate over time inbiological organisms are called age pigments. Lipofuscin, known as a hallmark of aging, refers to intracellular age pigments that accumulate mainly in the lysosomes of postrnitotic cells. This dissertation reports studies on the biochemical nature of lipofuscin and other age pigments, including their origin, mechanisms of formation, composition, structure and other properties.

    Since lipofuscin-extracts and lipid peroxidation products exhibit similar fluorescent characteristics, oxidative stress-induced lipid peroxidation is linked with age pigment formation. The initiation of lipid peroxidation resulting from oxygen free radicals was studied in a Tween 20-emulsified linoleic acid model system. Fenton reagents did not result in hydrogen abstraction-related diene conjugation. Also, different cOmbinations of Fe(II) and Fe(III) did not support the Fe(II):Fe(Ill) (1: 1) optimum ratio hypothesis. It is, therefore, concluded that perferryl ions or chelator-Fe-02 complexes are responsible for the first-chain initiation of lipid peroxidation in this model system.

    To elucidate a mitochondrion-lysosome hypothesis of lipofuscinogenesis, the oxidative stress-induced formation of lipofuscin-like fluorophores was studied in a testtube model using lysosomal-mitochondrial fractions. The sequential formation of TEARS, protein carbonyls and lipofuscin-like fluorophores was found. These findings add support to the concept that lipofuscin fonns in secondary lysosomes as a result of iron-catalyzed oxidative reactions involving autophagocytosed materials.

    Further, lipofuscin-like fluorescence was obtained during ascorbic acidautoxidation and from reaction products between ascorbic acid and amino compounds. The reaction between ascorbic acid and glutamine shows that such fluorophore formation is oxidation-dependent. On the basis of a comparison of the fluorophore formation mechanisms of lipid peroxidation, ascorbate oxidation and glycation reactions, we propose that carbonyl-protein crosslinking is a common biochemical reaction in aging processes.

    Striking discrepancy exists between the orange-yellow fluorescence of lipofuscin in situ and the blue fluorescence of lipofuscin-extracts. A concentration-dependent fluorescence shift was discovered using different lipofuscin-related fluorophores. The methodological difference between microfluorometry, by which lipofuscin is studied in highly condensed form, and spectrofluorometry, by which lipofuscin is studied at a very low concentration, is also clarified.

    These studies suggest that crosslinking between carbonyls and amino compounds may represent the major biochemical process responsible for the formation of age pigments and lipofuscin-like fluorophores.

  • 99596.
    Yin, Feng
    et al.
    Technical University of Darmstadt, Germany .
    Fritsche, Carsten
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gustafsson, Fredrik
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Zoubir, Abdelhak M.
    Technical University of Darmstadt, Germany .
    EM- and JMAP-ML Based Joint Estimation Algorithms for Robust Wireless Geolocation in Mixed LOS/NLOS Environments2014In: IEEE Transactions on Signal Processing, ISSN 1053-587X, E-ISSN 1941-0476, Vol. 62, no 1, p. 168-182Article in journal (Refereed)
    Abstract [en]

    We consider robust geolocation in mixed line-of-sight (LOS)/non-LOS (NLOS) environments in cellular radio networks. Instead of assuming known propagation channel states (LOS or NLOS), we model the measurement error with a general two-mode mixture distribution although it deviates from the underlying error statistics. To avoid offline calibration, we propose to jointly estimate the geographical coordinates and the mixture model parameters. Two iterative algorithms are developed based on the well-known expectation-maximization (EM) criterion and joint maximum a posteriori-maximum likelihood (JMAP-ML) criterion to approximate the ideal maximum-likelihood estimator (MLE) of the unknown parameters with low computational complexity. Along with concrete examples, we elaborate the convergence analysis and the complexity analysis of the proposed algorithms. Moreover, we numerically compute the Cramer-Rao lower bound (CRLB) for our joint estimation problem and present the best achievable localization accuracy in terms of the CRLB. Various simulations have been conducted based on a real-world experimental setup, and the results have shown that the ideal MLE can be well approximated by the JMAP-ML algorithm. The EM estimator is inferior to the JMAP-ML estimator but outperforms other competitors by far.

  • 99597.
    Yin, Feng
    et al.
    Technical University Darmstadt, Germany.
    Fritsche, Carsten
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, Faculty of Science & Engineering.
    Gustafsson, Fredrik
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, Faculty of Science & Engineering.
    Zoubir, Abdelhak M.
    Technical University Darmstadt, Germany.
    Received signal strength-based joint parameter estimation algorithm for robust geolocation in LOS/NLOS environments2013In: Proc. of 2013 IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP), 2013, p. 6471-6475Conference paper (Refereed)
    Abstract [en]

    We consider received-signal-strength-based robust geolocation in mixed line-of-sight/non-line-of-sight propagation environments. Herein, we assume a mode-dependent propagation model with unknown parameters. We propose to jointly estimate the geographical coordinates and propagation model parameters. In order to approximate the maximum-likelihood estimator (MLE), we develop an iterative algorithm based on the well-known expectation and maximization criterion. As compared to the standard ML implementation, the proposed algorithm is simpler to implement and capable of reproducing the MLE. Simulation results show that the proposed algorithm attains the best geolocation accuracy as the number of measurements increases.

  • 99598.
    Yin, Feng
    et al.
    Technical University of Darmstadt, Germany.
    Fritsche, Carsten
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gustafsson, Fredrik
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Zoubir, Abdelhak M
    Technical University of Darmstadt, Germany.
    TOA-Based Robust Wireless Geolocation and Cramér-Rao Lower Bound Analysis in Harsh LOS/NLOS Environments2013In: IEEE Transactions on Signal Processing, ISSN 1053-587X, E-ISSN 1941-0476, Vol. 61, no 9, p. 2243-2255Article in journal (Refereed)
    Abstract [en]

    We consider time-of-arrival based robust geolocation in harsh line-of-sight/non-line-of-sight environments. Herein, we assume the probability density function (PDF) of the measurement error to be completely unknown and develop an iterative algorithm for robust position estimation. The iterative algorithm alternates between a PDF estimation step, which approximates the exact measurement error PDF (albeit unknown) under the current parameter estimate via adaptive kernel density estimation, and a parameter estimation step, which resolves a position estimate from the approximate log-likelihood function via a quasi-Newton method. Unless the convergence condition is satisfied, the resolved position estimate is then used to refine the PDF estimation in the next iteration. We also present the best achievable geolocation accuracy in terms of the Cramér-Rao lower bound. Various simulations have been conducted in both real-world and simulated scenarios. When the number of received range measurements is large, the new proposed position estimator attains the performance of the maximum likelihood estimator (MLE). When the number of range measurements is small, it deviates from the MLE, but still outperforms several salient robust estimators in terms of geolocation accuracy, which comes at the cost of higher computational complexity.

  • 99599.
    Yin, Feng
    et al.
    Technical University of Darmstadt, Germany.
    Fritsche, Carsten
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Jin, Di
    Technical University of Darmstadt, Germany.
    Gustafsson, Fredrik
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Zoubir, Abdelhak M.
    Technical University of Darmstadt, Germany.
    Cooperative Localization in WSNs Using Gaussian Mixture Modeling: Distributed ECM Algorithms2015In: IEEE Transactions on Signal Processing, ISSN 1053-587X, E-ISSN 1941-0476, Vol. 63, no 6, p. 1448-1463Article in journal (Refereed)
    Abstract [en]

    We study cooperative sensor network localization in a realistic scenario where 1) the underlying measurement errors more probably follow a non-Gaussian distribution; 2) the measurement error distribution is unknown without conducting massive offline calibrations; and 3) non-line-of-sight identification is not performed due to the complexity constraint and/or storage limitation. The underlying measurement error distribution is approximated parametrically by a Gaussian mixture with finite number of components, and the expectation-conditional maximization (ECM) criterion is adopted to approximate the maximum-likelihood estimator of the unknown sensor positions and an extra set of Gaussian mixture model parameters. The resulting centralized ECM algorithms lead to easier inference tasks and meanwhile retain several convergence properties with a proof of the "space filling" condition. To meet the scalability requirement, we further develop two distributed ECM algorithms where an average consensus algorithm plays an important role for updating the Gaussian mixture model parameters locally. The proposed algorithms are analyzed systematically in terms of computational complexity and communication overhead. Various computer based tests are also conducted with both simulation and experimental data. The results pin down that the proposed distributed algorithms can provide overall good performance for the assumed scenario even under model mismatch, while the existing competing algorithms either cannot work without the prior knowledge of the measurement error statistics or merely provide degraded localization performance when the measurement error is clearly non-Gaussian.

  • 99600.
    Yin, Feng
    et al.
    Ericsson Research, Linköping, Sweden.
    Zhao, Yuxin
    Ericsson Research, Linköping, Sweden.
    Gunnarsson, Fredrik
    Ericsson Research, Linköping, Sweden.
    Fundamental Bounds on Position Estimation Using Proximity Reports2016Conference paper (Refereed)
    Abstract [en]

    There is a big trend nowadays toward indoor proximity report based positioning. A binary valued proximity report can be obtained opportunistically through event-triggering, leading to significantly reduced signaling overhead for wireless communications. In this paper, we aim to derive two types of fundamental lower bound, namely the Cram´er-Rao bound and the Barankin bound, on the mean-square-error of any proximity report based position estimator. Using the maximum-likelihood estimator as a representative example, we show that the Barankin bound is potentially much tighter than the Cram´er-Rao bound and conclude that the Barankin bound ought be better suited for benchmarking any proximity report based position estimator.

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