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  • 1.
    Botzanowski, Boris
    et al.
    Aix Marseille Univ, France.
    Donahue, Mary
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Silverå Ejneby, Malin
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
    Gallina, Alessandro L.
    Ctr Bioelect Med, Sweden; Karolinska Inst, Sweden.
    Ngom, Ibrahima
    Aix Marseille Univ, France.
    Missey, Florian
    Aix Marseille Univ, France.
    Acerbo, Emma
    Aix Marseille Univ, France.
    Byun, Donghak
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Carron, Romain
    Aix Marseille Univ, France.
    Cassara, Antonino M.
    Fdn Res Informat Technol Soc ITIS, Switzerland.
    Neufeld, Esra
    Fdn Res Informat Technol Soc ITIS, Switzerland.
    Jirsa, Viktor
    Aix Marseille Univ, France.
    Olofsson, Peder S.
    Ctr Bioelect Med, Sweden; Karolinska Inst, Sweden; EMUNE AB, Sweden.
    Glowacki, Eric Daniel
    Brno Univ Technol, Czech Republic.
    Williamson, Adam
    Aix Marseille Univ, France; Ctr Bioelect Med, Sweden; Karolinska Inst, Sweden.
    Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields2022In: Advanced Healthcare Materials, ISSN 2192-2640, E-ISSN 2192-2659, Vol. 11, no 17, article id 2200075Article in journal (Refereed)
    Abstract [en]

    Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.

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