liu.seSearch for publications in DiVA
Change search
Refine search result
1234567 1 - 50 of 75363
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 1.
    Willén, Julia
    Linköping University, REMESO - Institute for Research on Migration, Ethnicity and Society.
    1, 2, 3, 4 Israel is an apartheid state2024In: Mana antirasistisk tidskrift, ISSN 1403-6886, no 1Article in journal (Other (popular science, discussion, etc.))
    Abstract [en]

    The article provides a detailed review of apartheid's legal and political structure, and compiles literature and reports on the apartheid system in Israel.

  • 2.
    Feyer, Stefan P.
    et al.
    University of Konstanz, Germany.
    Pinaud, Bruno
    Unicersity of Bordeaux, France.
    Kobourov, Stephen
    University of Arizona, USA.
    Brich, Nicolas
    University of Tübingen, Germany.
    Krone, Michael
    University of Tübingen, Germany and New York University, USA.
    Kerren, Andreas
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering. Department of Computer Science and Media Technology, Linnaeus University, Sweden.
    Behrisch, Michael
    Utrecht University, Netherlands.
    Schreiber, Falk
    University of Konstanz, Germany and Monash University, Australia.
    Klein, Karsten
    University of Konstanz, Germany.
    2D, 2.5D, or 3D? An Exploratory Study on Multilayer Network Visualisations in Virtual Reality2024In: IEEE Transactions on Visualization and Computer Graphics, ISSN 1077-2626, E-ISSN 1941-0506, Vol. 30, no 1, p. 469-479Article in journal (Refereed)
    Abstract [en]

    Relational information between different types of entities is often modelled by a multilayer network (MLN) - a network with subnetworks represented by layers. The layers of an MLN can be arranged in different ways in a visual representation, however, the impact of the arrangement on the readability of the network is an open question. Therefore, we studied this impact for several commonly occurring tasks related to MLN analysis. Additionally, layer arrangements with a dimensionality beyond 2D, which are common in this scenario, motivate the use of stereoscopic displays. We ran a human subject study utilising a Virtual Reality headset to evaluate 2D, 2.5D, and 3D layer arrangements. The study employs six analysis tasks that cover the spectrum of an MLN task taxonomy, from path finding and pattern identification to comparisons between and across layers. We found no clear overall winner. However, we explore the task-to-arrangement space and derive empirical-based recommendations on the effective use of 2D, 2.5D, and 3D layer arrangements for MLNs.

  • 3.
    Hagström, Hannes
    et al.
    Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden; Division of Hepatology, Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden.
    Vessby, Johan
    Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden.
    Ekstedt, Mattias
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Mag- tarmmedicinska kliniken.
    Shang, Ying
    Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
    99% of patients with NAFLD meet MASLD criteria and natural history is therefore identical2024In: Journal of Hepatology, ISSN 0168-8278, E-ISSN 1600-0641, Vol. 80, no 2, p. e76-e77Article in journal (Other academic)
  • 4.
    Widerberg, Oscar
    et al.
    Free University Amsterdam.
    Bäckstrand, Karin
    Stockholms universitet.
    Lövbrand, Eva
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Centrum för klimatpolitisk forskning.
    Marquardt, Jens
    University of Darmstadt.
    Nasiritousi, Naghmeh
    Linköping University.
    A cautionary tale for polycentric governance: states' roles in orchestrating decarbonization2024In: Global Environmental Politics, ISSN 1526-3800, E-ISSN 1536-0091Article in journal (Refereed)
  • 5.
    Deb, Mainak
    et al.
    Wipro Technol, India.
    Dhal, Krishna Gopal
    Midnapore Coll Autonomous, India.
    Das, Arunita
    Midnapore Coll Autonomous, India.
    Hussien, Abdelazim
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering. Fayoum Univ, Egypt; Middle East Univ, Jordan; Appl Sci Private Univ, Jordan.
    Abualigah, Laith
    Al Ahliyya Amman Univ, Jordan; Al al Bayt Univ, Jordan; Univ Tabuk, Saudi Arabia; Lebanese Amer Univ, Lebanon; Yuan Ze Univ, Taiwan.
    Garai, Arpan
    Indian Inst Technol, India.
    A CNN-based model to count the leaves of rosette plants (LC-Net)2024In: Scientific Reports, E-ISSN 2045-2322, Vol. 14, no 1, article id 1496Article in journal (Refereed)
    Abstract [en]

    Plant image analysis is a significant tool for plant phenotyping. Image analysis has been used to assess plant trails, forecast plant growth, and offer geographical information about images. The area segmentation and counting of the leaf is a major component of plant phenotyping, which can be used to measure the growth of the plant. Therefore, this paper developed a convolutional neural network-based leaf counting model called LC-Net. The original plant image and segmented leaf parts are fed as input because the segmented leaf part provides additional information to the proposed LC-Net. The well-known SegNet model has been utilised to obtain segmented leaf parts because it outperforms four other popular Convolutional Neural Network (CNN) models, namely DeepLab V3+, Fast FCN with Pyramid Scene Parsing (PSP), U-Net, and Refine Net. The proposed LC-Net is compared to the other recent CNN-based leaf counting models over the combined Computer Vision Problems in Plant Phenotyping (CVPPP) and KOMATSUNA datasets. The subjective and numerical evaluations of the experimental results demonstrate the superiority of the LC-Net to other tested models.

  • 6.
    Fredäng Kämmerling, Nina
    et al.
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping.
    Tesselaar, Erik
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Medical radiation physics. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Booij, Ronald
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Erasmus MC, Netherlands.
    Fornander, Lotta
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Norrköping.
    Persson, Anders
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Farnebo, Simon
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
    A comparative study of image quality and diagnostic confidence in diagnosis and follow-up of scaphoid fractures using photon-counting detector CT and energy-integrating detector CT2024In: European Journal of Radiology, ISSN 0720-048X, E-ISSN 1872-7727, Vol. 173, article id 111383Article in journal (Refereed)
    Abstract [en]

    Purpose: Scaphoid fractures in patients and assessment of healing using PCD-CT have, as far as we know, not yet been studied. Therefore, the aim was to compare photon counting detector CT (PCD-CT) with energy integrating detector CT (EID-CT) in terms of fracture visibility and evaluation of fracture healing. Method: Eight patients with scaphoid fracture were examined with EID-CT and PCD-CT within the first week posttrauma, and with additional scans at 4, 6 and 8 weeks. Our clinical protocol for wrist examination with EID-CT was used (CTDIvol 3.1 +/- 0.1 mGy, UHR kernel Ur77). For PCD-CT matched radiation dose, reconstruction kernel Br89. Quantitative analyses of noise, CNR, trabecular and cortical sharpness, and bone volume fraction were conducted. Five radiologists evaluated the images for fracture visibility, fracture gap consolidation and image quality, and rated their confidence in the diagnosis. Results: The trabecular and cortical sharpness were superior in images obtained with PCD-CT compared with EIDCT. A successive reduction in trabecular bone volume fraction during the immobilized periods was found with both systems. Despite higher noise and lower CNR with PCD-CT, radiologists rated the image quality of PCD-CT as superior. The visibility of the fracture line within 1 -week post -trauma was rated higher with PCD-CT as was diagnostic confidence, but the subsequent assessments of fracture gap consolidation during healing process and the confidence in diagnosis were found equivalent between both systems. Conclusion: PCD-CT offers superior visibility of bone microstructure compared with EID-CT. The evaluation of fracture healing and confidence in diagnosis were rated equally with both systems, but the radiologists found primary fracture visibility and overall image quality superior with PCD-CT.

    The full text will be freely available from 2025-02-17 00:00
  • 7.
    Kircher, Katja
    et al.
    Swedish Natl Rd & Transport Res Inst VTI, Linkoping, Sweden.
    Ahlström, Christer
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Swedish Natl Rd & Transport Res Inst VTI, Linkoping, Sweden.
    A comparison of glance coding approaches for driver attention assessment2024In: Transportation Research Part F: Traffic Psychology and Behaviour, ISSN 1369-8478, E-ISSN 1873-5517, Vol. 100, p. 243-253Article in journal (Refereed)
    Abstract [en]

    Eye tracking is a common tool to assess drivers' attentional state, either in real-time with the goal to prevent incidents, or offline, to understand underlying processes. While seemingly objective, eye tracking data can be coded and interpreted in different ways, which can have substantial effects on the results. The objective of this paper is to highlight and discuss the possibilities and limitations of three different approaches to code glance data: the direction-based encoding, the target-based approach, and the purpose-based approach. The direction-based coding scheme de-scribes glances relative to the direction of travel. The target-based approach classifies the glance targets into different categories. The purpose-based approach needs additional layers of information to deduce the reason for the glance. This information encompasses road layout, traffic rules, and the presence and relevance of other traffic. Data from a field study with 23 participants driving an instrumented vehicle on an urban route was used to illustrate differences between the three methods. The results showed that the coding approach clearly affected the interpretation of the measured glance data. A purely target-based approach is limited by its inability to account for spare visual capacity and that also the absence of a target constitutes valuable information, and a purely direction-based approach does not account for the need to scan areas located off forward. The purpose-based approach requires contextual information that can be cumbersome to integrate. Regardless of the approach used, additional layers of contextual information increase understanding and interpretability, potentially at the cost of increased complexity. The three approaches are suitable for different contexts and their feasibility also depends on the availability of additional data. A key message is that context awareness improves the accuracy of driver attention monitoring and inattention identification.

  • 8.
    Racicot, Kelsey J.
    et al.
    Univ Lethbridge, Canada.
    Ham, Jackson R.
    Univ Lethbridge, Canada.
    Augustine, Jacqueline K.
    Ohio State Univ Lima, OH USA.
    Henriksen, Rie
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Wright, Dominic
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Iwaniuk, Andrew N.
    Univ Lethbridge, Canada.
    A Comparison of Telencephalon Composition among Chickens, Junglefowl, and Wild Galliforms2024In: Brain, behavior, and evolution, ISSN 0006-8977, E-ISSN 1421-9743, Vol. 99, no 1, p. 13-24Article in journal (Refereed)
    Abstract [en]

    Introduction: Domestication is the process of modifying animals for human benefit through selective breeding in captivity. One of the traits that often diverges is the size of the brain and its constituent regions; almost all domesticated species have relatively smaller brains and brain regions than their wild ancestors. Although the effects of domestication on the brain have been investigated across a range of both mammal and bird species, almost nothing is known about the neuroanatomical effects of domestication on the world's most common bird: the chicken (Gallus gallus). Methods: We compared the quantitative neuroanatomy of the telencephalon of white leghorn chickens with red junglefowl, their wild counterpart, and several wild galliform species. We focused specifically on the telencephalon because telencephalic regions typically exhibit the biggest differences in size in domesticate-wild comparisons. Results: Relative telencephalon size was larger in chickens than in junglefowl and ruffed grouse (Bonasa umbellus). The relative size of telencephalic regions did not differ between chickens and junglefowl, but did differ in comparison with ruffed grouse. Ruffed grouse had larger hyperpallia and smaller entopallial, nidopallial, and striatal volumes than chickens and junglefowl. Multivariate analyses that included an additional three wild grouse species corroborated these findings: chicken and junglefowl have relatively larger nidopallial and striatal volumes than grouse. Conversely, the mesopallial and hyperpallial volumes tended to be relatively smaller in chickens and junglefowl. Conclusion: From this suite of comparisons, we conclude that chickens do not follow a pattern of widespread decreases in telencephalic region sizes that is often viewed as typical of domestication. Instead, chickens have undergone a mosaic of changes with some regions increasing and others decreasing in size, and there are few differences between chickens and junglefowl.

  • 9.
    Bae, S. Sandra
    et al.
    Univ Colorado, CO 80309 USA.
    Fujiwara, Takanori
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Ynnerman, Anders
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, Faculty of Science & Engineering.
    Do, Ellen Yi-Luen
    Univ Colorado, CO 80309 USA.
    Rivera, Michael L.
    Univ Colorado, CO 80309 USA.
    Szafir, Danielle Albers
    Univ North Carolina Chapel Hill, NC USA.
    A Computational Design Pipeline to Fabricate Sensing Network Physicalizations2024In: IEEE Transactions on Visualization and Computer Graphics, ISSN 1077-2626, E-ISSN 1941-0506, Vol. 30, no 1, p. 913-923Article in journal (Refereed)
    Abstract [en]

    Interaction is critical for data analysis and sensemaking. However, designing interactive physicalizations is challenging as it requires cross-disciplinary knowledge in visualization, fabrication, and electronics. Interactive physicalizations are typically produced in an unstructured manner, resulting in unique solutions for a specific dataset, problem, or interaction that cannot be easily extended or adapted to new scenarios or future physicalizations. To mitigate these challenges, we introduce a computational design pipeline to 3D print network physicalizations with integrated sensing capabilities. Networks are ubiquitous, yet their complex geometry also requires significant engineering considerations to provide intuitive, effective interactions for exploration. Using our pipeline, designers can readily produce network physicalizations supporting selection-the most critical atomic operation for interaction-by touch through capacitive sensing and computational inference. Our computational design pipeline introduces a new design paradigm by concurrently considering the form and interactivity of a physicalization into one cohesive fabrication workflow. We evaluate our approach using (i) computational evaluations, (ii) three usage scenarios focusing on general visualization tasks, and (iii) expert interviews. The design paradigm introduced by our pipeline can lower barriers to physicalization research, creation, and adoption.

  • 10.
    Meng, Lingyin
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.
    Liu, Sheng
    Huaibei Normal Univ, Peoples R China.
    Borsa, Baris Ata
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering.
    Eriksson, Mats
    Linköping University, Department of Physics, Chemistry and Biology, Sensor and Actuator Systems. Linköping University, Faculty of Science & Engineering.
    Mak, Wing Cheung
    Chinese Univ Hong Kong, Peoples R China.
    A conducting polymer-based array with multiplex sensing and drug delivery capabilities for smart bandages2024In: COMMUNICATIONS MATERIALS, ISSN 2662-4443, Vol. 5, no 1, article id 28Article in journal (Refereed)
    Abstract [en]

    Effective individual wound management, particularly in cases of prolonged healing and increased infection vulnerability, has prompted the development of wound theranostics, combining real-time diagnostic assessment and on-demand treatment. Here, we present a multifunctional conducting polymer-based smart theranostic bandage that integrates pH sensing, pH-compensated uric acid (UA) biosensing, and on-demand antibiotic release using different conducting polymers, each leveraging their advantageous intrinsic properties. Specifically, the polyaniline-based pH sensor operates reversibly across a pH range of 4-10, while the functionalized poly(3,4-ethylenedioxythiophene)-based UA biosensor exhibits a linear response up to 0.9 mM UA. Simultaneous detection of pH and UA allows accurate UA determination via pH compensation. Upon detecting abnormal pH/UA levels, the polypyrrole-based drug carrier releases ciprofloxacin via 0.6 V electrical stimulation, successfully inhibiting bacterial growth in vitro. The array is assembled as a 3D patch, connected to a flexible printed circuit board, and embedded in a wound bandage, offering potential for remote wound monitoring, targeted treatment, and wireless wound management. Smart devices for wound management combine biosensing with drug release. Here, a smart theranostic bandage is reported that can detect pH and uric acid levels and release antibiotics as necessary, all of which can be done remotely.

  • 11.
    Zhou, Yijun
    et al.
    Div. of Biomedical Engineering, Dept. of Materials Science and Engineering, Uppsala University, Sweden.
    Klintström, Eva
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Radiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Klintström, Benjamin
    Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Huddinge, Sweden.
    Ferguson, Stephen J.
    Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.
    Helgason, Benedikt
    Institute for Biomechanics, ETH Zürich, Zürich, Switzerland.
    Persson, Cecilia
    Div. of Biomedical Engineering, Dept. of Materials Science and Engineering, Uppsala University, Sweden.
    A convolutional neural network-based method for the generation of super-resolution 3D models from clinical CT images2024In: Computer Methods and Programs in Biomedicine, ISSN 0169-2607, E-ISSN 1872-7565, Vol. 245, article id 108009Article in journal (Refereed)
    Abstract [en]

    Background and Objective

    The accurate evaluation of bone mechanical properties is essential for predicting fracture risk based on clinical computed tomography (CT) images. However, blurring and noise in clinical CT images can compromise the accuracy of these predictions, leading to incorrect diagnoses. Although previous studies have explored enhancing trabecular bone CT images to super-resolution (SR), none of these studies have examined the possibility of using clinical CT images from different instruments, typically of lower resolution, as a basis for analysis. Additionally, previous studies rely on 2D SR images, which may not be sufficient for accurate mechanical property evaluation, due to the complex nature of the 3D trabecular bone structures. The objective of this study was to address these limitations.

    Methods

    A workflow was developed that utilizes convolutional neural networks to generate super-resolution 3D models across different clinical CT instruments. The morphological and finite-element-derived mechanical properties of these super-resolution models were compared with ground truth models obtained from micro-CT scans.

    Results

    A significant improvement in analysis accuracy was demonstrated, where the new SR models increased the accuracy by up to 700% compared with the low-resolution data, i.e. clinical CT images. Additionally, we found that the mixture of different CT image datasets may improve the super-resolution model performance.

    Conclusions

    Super-resolution images, generated by convolutional neural networks, outperformed clinical CT images in the determination of morphological and mechanical properties. The developed workflow could be implemented for fracture risk prediction, potentially leading to improved diagnoses and subsequent clinical decision making.

  • 12.
    Taxén, Lars
    Linköping University, Department of Computer and Information Science, Human-Centered systems. Linköping University, Faculty of Science & Engineering.
    A dialectical approach for transcending structuralism2024In: Signs in Activities: New Directions for Integrational Linguistics / [ed] D. Duncker, A. Pablé, London: Routledge , 2024, p. 81-105Chapter in book (Refereed)
    Abstract [en]

    The purpose of this contribution is to explore how a dialectical approach may further Integrational Linguistics into transcending structuralism. The strategy employed is to articulate the biomechanical and macrosocial factors in the communicational infrastructure as neurobiological attractors and social anchors respectively. Hence, the inquiry focuses on the dialectical relation between an individual’s neurobiological structure and her ability to confer signhood onto activity-relevant phenomena in the social environment. This makes it possible to conceive new directions for Integrational Linguistics by rethinking central aspects such as contextuality, indeterminacy, cotemporality, integration, and coordination. Conjectural as these directions may be, I put forward that the dialectical approach provides a promising launchpad for further inquiries into transcending structuralism and beyond.

    The full text will be freely available from 2025-09-27 11:45
  • 13.
    Zhao, Qian
    et al.
    Dalian Univ Technol, Peoples R China; Dalian Univ Technol, Peoples R China.
    Li, Yilin
    Dalian Univ Technol, Peoples R China.
    Zhang, Zhouxiaolong
    Dalian Univ Technol, Peoples R China.
    Dai, Li
    Dalian Med Univ, Peoples R China; Dalian Med Univ, Peoples R China.
    Liu, Xuhan
    Dalian Municipal Cent Hosp, Peoples R China; Dalian Municipal Cent Hosp, Peoples R China.
    Sun, Yanhui
    Dalian Minzu Univ, Peoples R China; Dalian Minzu Univ, Peoples R China.
    Zhao, Dan
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Zhu, Nan
    Dalian Univ Technol, Peoples R China; Dalian Univ Technol, Peoples R China; Dalian Univ Technol, Peoples R China.
    A flexible ammonia sensor based on MXene membrane with high sensitivity2024In: Electroanalysis, ISSN 1040-0397, E-ISSN 1521-4109Article in journal (Refereed)
    Abstract [en]

    Ammonia (NH3) of high concentration will pose a threat to ecological environment or human health, and exhaled NH3 is significant in disease monitoring and diagnosis. Thus, developing a highly sensitive gas sensor is significant to monitor NH3 concentration in complex environments. However, traditional NH3 sensors either need high working temperature, or face the challenge of poor conductivity/ sensitivity. In this work, NH3 sensors based on self-assembled MXene membrane have been fabricated. As-prepared sensors show a high sensitivity of 2.10 ppm-1 towards extremely low concentrations of NH3 (ppb level) at room temperature, attributed to large surface area and high conductivity. In addition, the sensors also display low detection limit (50 ppb), fast response time (41 s), good recoverability, long-term stability (15 days) and excellent flexibility (1000 bending cycles) towards NH3. The results provide insights into the development of highly sensitive NH3 sensors for industrial or biomedical applications. image

  • 14.
    Tybrandt, Klas
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    A gentle nerve wrapper2024In: Nature Materials, ISSN 1476-1122, E-ISSN 1476-4660Article in journal (Refereed)
    Abstract [en]

    Integrating electrochemically actuated soft robotics with ultra-flexible microelectrodes enables reversible and gentle wrapping around nerves for high-quality recordings.

  • 15.
    Li, Qifan
    et al.
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Huang, Jun-Da
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Liu, Tiefeng
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    van der Pol, Tom
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Zhang, Qilun
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. Wallenberg Wood Science Center.
    Jeong, Sang Young
    Korea Univ, South Korea.
    Stoeckel, Marc-Antoine
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. N Ink AB, SE-60221 Norrkoping, Sweden.
    Wu, Hanyan
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Zhang, Silan
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Liu, Xianjie
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Woo, Han Young
    Korea Univ, South Korea.
    Fahlman, Mats
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Yang, Chiyuan
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. N Ink AB, SE-60221 Norrkoping, Sweden.
    Fabiano, Simone
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering. N Ink AB, SE-60221 Norrkoping, Sweden.
    A Highly Conductive n-Type Conjugated Polymer Synthesized in Water2024In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126Article in journal (Refereed)
    Abstract [en]

    Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a benchmark hole-transporting (p-type) polymer that finds applications in diverse electronic devices. Most of its success is due to its facile synthesis in water, exceptional processability from aqueous solutions, and outstanding electrical performance in ambient. Applications in fields like (opto-)electronics, bioelectronics, and energy harvesting/storage devices often necessitate the complementary use of both p-type and n-type (electron-transporting) materials. However, the availability of n-type materials amenable to water-based polymerization and processing remains limited. Herein, we present a novel synthesis method enabling direct polymerization in water, yielding a highly conductive, water-processable n-type conjugated polymer, namely, poly[(2,2 '-(2,5-dihydroxy-1,4-phenylene)diacetic acid)-stat-3,7-dihydrobenzo[1,2-b:4,5-b ']difuran-2,6-dione] (PDADF), with remarkable electrical conductivity as high as 66 S cm(-1), ranking among the highest for n-type polymers processed using green solvents. The new n-type polymer PDADF also exhibits outstanding stability, maintaining 90% of its initial conductivity after 146 days of storage in air. Our synthetic approach, along with the novel polymer it yields, promises significant advancements for the sustainable development of organic electronic materials and devices.

  • 16.
    Tadaros, Marduch
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering. Lulea Univ Technol, Sweden.
    Kyriakakis, Nikolaos A.
    Tech Univ Crete, Greece.
    A Hybrid Clustered Ant Colony Optimization Approach for the Hierarchical Multi-Switch Multi-Echelon Vehicle Routing Problem with Service Times2024In: Computers & industrial engineering, ISSN 0360-8352, E-ISSN 1879-0550, Vol. 190, article id 110040Article in journal (Refereed)
    Abstract [en]

    In this paper, the Hierarchical Multi Switch Multi Echelon Vehicle Routing Problem with Service Times (HMSME-VRP-ST) is presented. This novel problem considers distribution applications in which goods are delivered either directly from a central depot or through intermediate facilities called switch points. Commodities are loaded into interchangeable containers called swap bodies at the central depot, and can be transferred from one vehicle to another at the switch points. The goal is to minimize fixed and variable costs of the vehicle fleet and swap -bodies while serving a predetermined set of customers. The routes are constrained by time and swap bodies by loading capacity. A mathematical model of the HMSME-VRP-ST is presented, and a Hybrid Clustered Ant Colony Optimization (HCACO) algorithm is proposed to address the complexity of the problem. The approach utilizes the ant -based clustering algorithm, combining the density and connectivity properties of clustering for creating promising neighborhoods with the solution construction methodology and pheromonebased memory of the Ant Colony Optimization framework. Additionally, two local search schemes based on Variable Neighborhood Descent are incorporated to further improve the generated solutions. The behavior of each HCACO variant is analyzed, and their results are compared to a Greedy Randomized Adaptive Search Procedure metaheuristic in 36 newly generated benchmarks comprising of clustered, uniformly random, and mixed clustered -random instances.

  • 17.
    Larsson, Torbjörn
    et al.
    Linköping University, Department of Mathematics, Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Quttineh, Nils-Hassan
    Linköping University, Department of Mathematics, Applied Mathematics. Linköping University, Faculty of Science & Engineering.
    Åkerholm, Ida
    Linköping University, Department of Mathematics. Linköping University, Faculty of Science & Engineering.
    A Lagrangian bounding and heuristic principle for bi-objective discrete optimization2024In: Operational Research, ISSN 1109-2858, E-ISSN 1866-1505, Vol. 24, no 2, article id 14Article in journal (Refereed)
    Abstract [en]

    Lagrangian relaxation is a common and often successful way to approach computationally challenging single-objective discrete optimization problems with complicating side constraints. Its aim is often twofold; first, it provides bounds for the optimal value, and, second, it can be used to heuristically find near-optimal feasible solutions, the quality of which can be assessed by the bounds. We consider bi-objective discrete optimization problems with complicating side constraints and extend this Lagrangian bounding and heuristic principle to such problems. The Lagrangian heuristic here produces non-dominated candidates for points on the Pareto frontier, while the bounding forms a polyhedral outer approximation of the Pareto frontier, which can be used to assess the quality of the candidate points. As an illustration example we consider a facility location problem in which both CO2 emission and cost should be minimized. The computational results are very encouraging, both with respect to bounding and the heuristically found non-dominated solutions. In particular, the Lagrangian bounding is much stronger than the outer approximation given by the Pareto frontier of the problem's linear programming relaxation.

  • 18. Order onlineBuy this publication >>
    Johansson, Helena
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Nursing Sciences and Reproductive Health. Linköping University, Faculty of Medicine and Health Sciences.
    A life in the shadow of COPD: Symptom burden, caregiver burden and strategies to manage daily life2024Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    Chronic obstructive pulmonary disease (COPD) is an irreversible obstructive lung disease. In Sweden, 400,000 to 700,000 individuals are affected by this disease, and it is the third most common diagnosis. Among those with COPD, approximately 3% are at Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages III and IV, representing severe disease. Persons affected by COPD have symptoms such as breathing problems, cough, and increased mucus production. The persons affected by COPD and the next of kin have an affected life. The affected person need support from the next of kin and from society.

    This thesis aimed to identify, describe, and deepen the knowledge around the symptom burden in persons affected by COPD, the caregiver burden of their next of kin, and the need for support.

    In the work described in this thesis, qualitative interviews were performed with 25 persons affected by COPD in GOLD stages III and IV and 22 of their next of kin. The interviews were analysed using thematic analysis, according to Braun and Clarke. Quantitative data were also collected from 112 affected persons and 71 of their next of kin, which comprised background data, symptom burden scored with Revised Memorial Symptom Assessment Scale (RMSAS), caregiver burden scored with Caregiver Reaction Assessment (CRA), sense of coherence scored with Sense Of Coherence 13 item (SOC13) and support scored with Social Support Questionnaire six items (SSQ6). These quantitative variables were analysed using frequencies, means and independent t-tests. The total data corpus was then compared and contrasted, examining similarities and differences using Teddlie and Tashakkori’s mixed method. Finally, an integrative review of 68 studies was performed, which identified and summarised the support given to persons affected by COPD and their next of kin. Also, the effects of the support given were also identified and summarised.

    The results showed that those persons affected by COPD have a symptom burden in the form of an altered everyday life. The next of kin experience a caregiver burden in the form of changed roles, putting life on hold, and standing aside. Taken together, the findings show that the person affected by COPD and the next of kin rate the burden in one way but express it slightly differently in their own words. The affected persons and their next of kin need support to handle everyday life. In Sweden, most support is currently in the form of giving information, promoting physical activity, and providing medical treatment, but these do not always have the desired effects.

    In conclusion, persons affected by COPD and their next of kin wish to have person-centred support, involving face-to-face consultations in the clinic or at home, to minimise the burdens that they face.

    List of papers
    1. To live a life with COPD: the consequences of symptom burden
    Open this publication in new window or tab >>To live a life with COPD: the consequences of symptom burden
    2019 (English)In: The International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1176-9106, E-ISSN 1178-2005, Vol. 14, p. 905-909Article in journal (Refereed) Published
    Abstract [en]

    Background: Chronic obstructive pulmonary disease (COPD) is a prevalent illness that, due to its symptoms and treatment, entails a significant burden for the affected person, and his/her family, health care and private finances. Today, knowledge and understanding are sparse regarding COPD-affected persons’ own lived experiences and about the symptom burden and its effect on their daily life. Due to this knowledge gap the aim of this study was to identify and describe the symptom burden and its effect on daily life in people with COPD, based on their own lived experiences.

    Subject and method: Eleven males and 14 females in GOLD stages III and IV, in an age range of 58–82 years, were interviewed. An interview guide was used to direct the face-to-face interviews. Data was analyzed with thematic analysis following the six steps according to Braun and Clarke.

    Results: The results highlighted one theme: an altered everyday life. The altered everyday life leads to a need for support to handle everyday life and for different strategies to live as desired. Persons with COPD need to take each day as it comes and their life is not easy to plan since it depends on how they feel from day to day. Life is handled with several strategies such as breathing techniques, and ways to take care of the home and garden as well as the emotions. Support from the next of kin, society and the health care service is important.

    Conclusion: This study provides the insight that persons with COPD in stages III and IV have an altered life caused by the symptom burden. They must struggle with strategies to handle everyday life. There is a need of support from the next of kin and society to facilitate daily living, but this support needs to be well-balanced.

    Place, publisher, year, edition, pages
    Auckland, New Zealand: Dove Medical Press Ltd.(DovePress), 2019
    Keywords
    chronic obstructive pulmonary disease, symptom burden, daily life, thematic analysis
    National Category
    Clinical Medicine
    Identifiers
    urn:nbn:se:liu:diva-156645 (URN)10.2147/COPD.S192280 (DOI)000467095200002 ()
    Available from: 2019-05-02 Created: 2019-05-02 Last updated: 2024-04-26Bibliographically approved
    2. The experience of caregiver burden when being next of kin to a person with severe chronic obstructive pulmonary disease: A qualitative study
    Open this publication in new window or tab >>The experience of caregiver burden when being next of kin to a person with severe chronic obstructive pulmonary disease: A qualitative study
    2023 (English)In: Chronic Respiratory Disease, ISSN 1479-9723, E-ISSN 1479-9731, Vol. 20, article id 14799731231168897Article in journal (Refereed) Published
    Abstract [en]

    BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an inflammatory and irreversible lung disease. For next of kin caregiver burden can be a consequence of the situation of being close to a person affected by a chronic disease and in need of help. When there is an imbalance between stressors and resources to cope with the situation, caregiver burden emerges. Knowledge is sparse about how the caregiver burden is experienced by the next of kin. Therefore, the aim of this study is to identify and describe the caregiver burden experienced by next of kin of persons with severe COPD.

    METHOD: Qualitative interviews with 21 next of kin were conducted. Thematic analysis was used in accordance with the six steps of Braun and Clarke.

    RESULTS: The next of kin experience caregiver burden as 1) changed roles in daily life 2) putting life on hold 3) to stand aside. The next of kin are in need of support to manage daily life.

    CONCLUSIONS: The caregiver burden affect the next of kin physically and emotionally. To prevent advance consequences, person-centered care can be used to support the next of kin in the situation.

    Place, publisher, year, edition, pages
    Sage Publications, 2023
    Keywords
    COPD, Caregiver burden, informal caregiver, interviews, next of kin, thematic analysis
    National Category
    Nursing
    Identifiers
    urn:nbn:se:liu:diva-193249 (URN)10.1177/14799731231168897 (DOI)000969346800001 ()37042067 (PubMedID)
    Note

    Funding: Region Ostergotland; Forskningsradet i Sydostra Sverige

    Available from: 2023-04-25 Created: 2023-04-25 Last updated: 2024-04-26
    3. Chronic obstructive pulmonary diseases impact on the affected person and next of kin: A mixed methods study
    Open this publication in new window or tab >>Chronic obstructive pulmonary diseases impact on the affected person and next of kin: A mixed methods study
    2023 (English)In: Chronic Illness, ISSN 1742-3953, E-ISSN 1745-9206Article in journal (Refereed) Epub ahead of print
    Abstract [en]

    Objectives Severe chronic obstructive pulmonary disease affects and changes the lives of both affected persons and next of kin. There is a need for support and a sense of coherence to manage the life situation and minimize the symptom and caregiver burden. The aim of this study was to diverge or converge views of symptom burden, caregiver burden, the need for support, and sense of coherence in persons with chronic obstructive pulmonary disease and their next of kin to gain a deeper and broader knowledge and understanding. Methods A mixed methods study with data from interviews and four validated questionnaires from persons affected by chronic obstructive pulmonary disease in GOLD stages III and IV and their next of kin. Results Questionnaires from 112 persons affected by chronic obstructive pulmonary disease, and 71 next of kin, together with 25 and 21 interviews, show that; there is a difference between estimated symptoms and caregiver burden and experiences expressed in their own words. There is also a defect regarding meaningfulness, comprehensibility, and manageability affecting daily life. Symptoms and caregiver burden, together with the sense of coherence, strengthen the need for support. Discussion The complexity of the life situation leads to a need for supportive interventions to strengthen internal and external resources.

    Place, publisher, year, edition, pages
    SAGE PUBLICATIONS LTD, 2023
    Keywords
    caregiver burden; chronic obstructive pulmonary disease; sense of coherence; support; symptom burden
    National Category
    Public Health, Global Health, Social Medicine and Epidemiology
    Identifiers
    urn:nbn:se:liu:diva-195311 (URN)10.1177/17423953231175971 (DOI)000999932800001 ()37192646 (PubMedID)
    Available from: 2023-06-20 Created: 2023-06-20 Last updated: 2024-05-02
    Download full text (pdf)
    fulltext
    Download (png)
    presentationsbild
  • 19.
    af Geijerstam, Peder
    et al.
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Primary Care Center, Primary Health Care Center Cityhälsan Centrum.
    Joelsson, Annelie
    Region Östergötland, Primary Care Center, Primary Health Care Center Cityhälsan Centrum.
    Rådholm, Karin
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Primary Care Center, Primary Health Care Center Kärna. The George Institute for Global Health, University of New South Wales, Sydney, Australia.
    Nyström, Fredrik H
    Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Primary Care Center, Primary Health Care Center Cityhälsan Centrum. Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine.
    A low dose of daily licorice intake affects renin, aldosterone, and home blood pressure in a randomized crossover trial2024In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 119, no 3, p. 682-691Article in journal (Refereed)
    Abstract [en]

    Background

    Licorice, through the effects of glycyrrhizic acid (GA), raises blood pressure (BP). The World Health Organization has suggested that 100 mg GA/d would be unlikely to cause adverse effects, but of 13 previously published studies none have been randomized and controlled and independently quantified the GA content.

    Objective

    Our aim was to analyze the effects on home BP of a daily licorice intake containing 100 mg GA.

    Methods

    Healthy volunteers were randomly assigned to start with either licorice or a control product in a nonblinded, 2 × 2 crossover study. Home BP was measured daily, and blood samples were collected at the end of each 2-wk period.

    Results

    There were 28 participants and no dropouts. The median age was 24.0 y (interquartile range 22.8–27.0 y). During the licorice compared with control intake period, the systolic home BP increased [mean difference: 3.1 mm Hg (95% confidence interval [CI]: 0.8, 5.4 mm Hg) compared with −0.3 mm Hg (95% CI: −1.8, 1.3 mm Hg); P = 0.018] and renin and aldosterone were suppressed [mean change: −30.0% (95% CI: −56.7%, −3.3%) compared with 15.8% (95% CI: −12.8%, 44.4%); P = 0.003; and −45.1% (95% CI: −61.5%, −28.7%) compared with 8.2% (95% CI: −14.7%, 31.1%); P <0.001, respectively]. In the quartile of participants with the most pronounced suppression of renin and aldosterone, N-terminal prohormone of brain natriuretic peptide concentration increased during the licorice compared with control period [mean change: 204.1% (95% CI: −11.6%, 419.7%) compared with 72.4% (95% CI: −52.2%, 197.1%); P = 0.016].

    Conclusions

    We found licorice to be more potent than previously known, with significant increases in BP, after a daily intake of only 100 mg GA. Thus, the safe limit of intake of this substance might need to be reconsidered.

  • 20.
    Johansson, Björn J.E.
    et al.
    Linköping University, Department of Computer and Information Science, Human-Centered Systems. Linköping University, Faculty of Arts and Sciences.
    Eriksson, Pär
    Swedish Defence Research Agency.
    A maturity model to guide inter-organisational crisis management and response exercises2024In: International Journal of Disaster Risk Reduction, ISSN 2212-4209, Vol. 106, article id 104413Article in journal (Refereed)
    Abstract [en]

    This paper proposes a six-step maturity ladder for inter-organizational collaborative capability in crisis management and response operations. The paper argues that collaborative crisis management and response can be seen as a case of complex adaptive systems, where awareness of the organizational context of crisis response, technical interoperability, and individual relations are drivers that enable rapid and successful mobilization of crisis response. The maturity ladder provides a link between the capabilities necessary for collaboration possessed by individual crisis response entities and the overall system maturity in terms of collaborative crisis management capability. It can inter alia be used as a basis for a discussion when inter-organizational exercises are appropriate and when focus must remain on the development of the capabilities of individual crisis response entities.

  • 21.
    Zhou, Shengyang
    et al.
    Sichuan Univ, Peoples R China; Uppsala Univ, Sweden.
    Zhang, Yilin
    Sichuan Univ, Peoples R China.
    Li, Xuan
    Sichuan Univ, Peoples R China.
    Xu, Chao
    Uppsala Univ, Sweden.
    Halim, Joseph
    Linköping University, Department of Physics, Chemistry and Biology, Materials design. Linköping University, Faculty of Science & Engineering.
    Cao, Shuai
    Inst High Performance Comp, Singapore.
    Rosén, Johanna
    Linköping University, Department of Physics, Chemistry and Biology, Materials design. Linköping University, Faculty of Science & Engineering.
    Stromme, Maria
    Uppsala Univ, Sweden.
    A mechanically robust spiral fiber with ionic-electronic coupling for multimodal energy harvesting2024In: Materials Horizons, ISSN 2051-6347, E-ISSN 2051-6355Article in journal (Refereed)
    Abstract [en]

    Wearable electronics are some of the most promising technologies with the potential to transform many aspects of human life such as smart healthcare and intelligent communication. The design of self-powered fabrics with the ability to efficiently harvest energy from the ambient environment would not only be beneficial for their integration with textiles, but would also reduce the environmental impact of wearable technologies by eliminating their need for disposable batteries. Herein, inspired by classical Archimedean spirals, we report a metastructured fiber fabricated by scrolling followed by cold drawing of a bilayer thin film of an MXene and a solid polymer electrolyte. The obtained composite fibers with a typical spiral metastructure (SMFs) exhibit high efficiency for dispersing external stress, resulting in simultaneously high specific mechanical strength and toughness. Furthermore, the alternating layers of the MXene and polymer electrolyte form a unique, tandem ionic-electronic coupling device, enabling SMFs to generate electricity from diverse environmental parameters, such as mechanical vibrations, moisture gradients, and temperature differences. This work presents a design rule for assembling planar architectures into robust fibrous metastructures, and introduces the concept of ionic-electronic coupling fibers for efficient multimodal energy harvesting, which have great potential in the field of self-powered wearable electronics. In this work, a concept of ionic-electronic coupling fibers by integrating a 2D MXene and a polymer electrolyte to fabricate spiral metastructures is proposed to realize multimodal power generation from various sources simultaneously.

  • 22.
    Hutton, Steven
    et al.
    Lancaster University Management School.
    Demir, Robert
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Eldridge, Stephen
    Lancaster University Management School.
    A microfoundational view of the interplay between open innovation and a firm's strategic agility2024In: Long range planning, ISSN 0024-6301, E-ISSN 1873-1872, p. 102429-102429, article id 102429Article in journal (Refereed)
    Abstract [en]

    Open innovation can support firms looking to deploy strategic agility through product innovations during periods of market and technological change. However, existing research lacks a comprehensive understanding of the microfoundations that underlie strategic agility in the context of open innovation. We address this gap using an in-depth analysis of a firm's open innovation activities in support of new product development (NPD). Our analysis reveals that open innovation can help leverage NPD processes to drive technological innovations in response to changing market conditions. Under such circumstances, open innovation enables firms to deploy strategic agility by continually developing the product portfolio. Our study reveals six mechanisms that enable three mutually complementary practices of agility: knowledge-based agility at the firm-environment interface, behavioural agility in the firm's decision-making process, and organisational agility in the internal NPD process. We theorise the interplay between the mechanisms that constitute each practice and, in doing so, shed light on how they contribute to firm-level strategic agility.

  • 23.
    Ebeed, Mohamed
    et al.
    Sohag Univ, Egypt; Univ Jaen, Spain.
    Abdelmotaleb, Mohamed A.
    Sohag Univ, Egypt.
    Khan, Noor Habib
    North China Elect Power Univ, Peoples R China.
    Jamal, Raheela
    North China Elect Power Univ, Peoples R China.
    Kamel, Salah
    Aswan Univ, Egypt.
    Hussien, Abdelazim
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering. Fayoum Univ, Egypt; Middle East Univ, Jordan.
    Zawbaa, Hossam M.
    Beni Suef Univ, Egypt; Appl Sci Private Univ, Jordan.
    Jurado, Francisco
    Univ Jaen, Spain.
    Sayed, Khairy
    Sohag Univ, Egypt.
    A Modified Artificial Hummingbird Algorithm for solving optimal power flow problem in power systems2024In: Energy Reports, E-ISSN 2352-4847, Vol. 11, p. 982-1005Article in journal (Refereed)
    Abstract [en]

    Optimal power flow (OPF) problem solution is a crucial task for the operators and decision makers to assign the best setting of the system components to obtain the most economic, environmental, and technical suitable state. Artificial Hummingbird Algorithm is a recent optimization algorithm that has been applied to solving several optimization problems. In this paper, a Modified Artificial Hummingbird Algorithm (MAHA) is proposed for improving the performance of the orignal Artificial Hummingbird Algorithm as well as effectivelly solve the OPF problem. The proposed MAHA is based on improving the searching capability by boosting the exploitation using the bandwidth motion around the best solution, while the exploration process is improved using the Levy flight distribution motion and the fitness-distance balance selection. This modified version helps overcome issues such as stagnation, premature convergence, and a propensity for local optima when tackling complex, nonlinear, and non-convex optimization problems like OPF. In order to confirm the effectiveness of the proposed algorithm, a series of tests are conducted on 23 standard benchmark functions, including CEC2020. The resulting outcomes are then compared to those obtained using other algorithms such as fitness-distance balance selection-based stochastic fractal search (FDBSFS), antlion optimizer (ALO), whale optimization algorithm (WOA), sine-cosine algorithm (SCA), fitness-distance balance and learning based artificial bee colony (FDB-TLABC), and traditional artificial hummingbird algorithm (AHA).The proposed algorithm is evaluated by solving the OPF problem with multiple objective functions on the IEEE 30-bus system. These objectives include fuel cost, fuel cost with valve loading effects, power losses, emissions, and voltage profile. Additionally, the algorithm's effectiveness is further assessed by testing it on single objective functions using medium and large-scale IEEE 57 and 118-bus networks.The results obtained by the proposed MAHA demonstrate its power and superiority for solving the OPF problem as well as the standard benchmark functions , surpassing the performance of other reported techniques.

  • 24.
    Bao, Chunxiong
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Electronic and photonic materials. Linköping University, Faculty of Science & Engineering. Nanjing Univ, Peoples R China.
    Yuan, Zhongcheng
    Linköping University, Department of Physics, Chemistry and Biology, Electronic and photonic materials. Linköping University, Faculty of Science & Engineering. Univ Oxford, England.
    Niu, Wenxiao
    Nanjing Univ, Peoples R China.
    Yang, Jie
    Nanjing Tech Univ, Peoples R China; Nanjing Tech Univ, Peoples R China.
    Wang, Zijian
    Nanjing Univ, Peoples R China.
    Yu, Tao
    Nanjing Univ, Peoples R China.
    Wang, Jianpu
    Nanjing Tech Univ, Peoples R China; Nanjing Tech Univ, Peoples R China; Changzhou Univ, Peoples R China; Changzhou Univ, Peoples R China.
    Gao, Feng
    Linköping University, Department of Physics, Chemistry and Biology, Electronic and photonic materials. Linköping University, Faculty of Science & Engineering. Westlake Univ, Peoples R China; Westlake Univ, Peoples R China.
    A multifunctional display based on photo-responsive perovskite light-emitting diodes2024In: NATURE ELECTRONICS, ISSN 2520-1131Article in journal (Refereed)
    Abstract [en]

    Current display screens are typically only used for information display, but can have a range of different sensors integrated into them for functions such as touch control, ambient light sensing and fingerprint sensing. Photo-responsive light-emitting diodes (LEDs), which can display information and respond to light excitation, could be used to develop future ultra-thin and large screen-to-body ratio screens. However, photo-response is difficult to achieve with conventional display technologies. Here, we report a multifunctional display that uses photo-responsive metal halide perovskite LEDs as pixels. The perovskite LED display can be simultaneously used as a touch screen, ambient light sensor and image sensor (including for fingerprint drawing) without integrating any additional sensors. The light-to-electricity conversion efficiency of the pixels also allow the display to act as a photovoltaic device that can charge the equipment. Photo-responsive metal halide perovskite light-emitting diodes can be used to create a multifunctional display that can function as a touch screen, ambient light sensor and image sensor.

  • 25.
    Ananno, Anan Ashrabi
    et al.
    Linköping University, Department of Management and Engineering, Product Realisation. Linköping University, Faculty of Science & Engineering.
    Ribeiro, Luis
    Linköping University, Department of Management and Engineering, Product Realisation. Linköping University, Faculty of Science & Engineering.
    A Multi-Heuristic Algorithm for Multi-Container 3-D Bin Packing Problem Optimization Using Real World Constraints2024In: IEEE Access, E-ISSN 2169-3536, Vol. 12, p. 42105-42130Article in journal (Refereed)
    Abstract [en]

    With the growing demand for sustainable and optimal packaging solutions, this study proposes a novel two-stage algorithm for the multi-container three-dimensional bin packing problem. The research addresses this problem within the context of a real-world industrial scenario and implements several practical constraints including: full shipment, customer positioning requirements, and product geometric interlocking, for increased stability and with the purpose of minimizing the use of plastic wrapping and/or additional supporting surfaces. The main optimization target is to minimize the total number of containers used in the palletization process of custom orders with varying degrees of complexity. The proposed algorithm includes two stages/phases of processing. In the first phase, the algorithm uses constructive heuristics to generate homogeneous product layers. The layers are then stacked to produce blocks, which are then placed on individual containers or pallets. The second phase packs the leftover items using a genetic algorithm. The performance of the proposed solution is benchmarked using real-world industrial data, as well as a more classic academic benchmark. It is demonstrated, across a very large set of orders, that the algorithm always achieves solutions for full palletization of the orders. The analysis shows that the approach is generic and the quality of the solutions generated is relatively even for both small and large, homogeneous and heterogeneous problem instances.

  • 26.
    Niskanen, Johan
    et al.
    Linköping University, Department of Thematic Studies, Technology and Social Change. Linköping University, Faculty of Arts and Sciences.
    Anshelm, Jonas
    Linköping University, Department of Thematic Studies, Technology and Social Change. Linköping University, Faculty of Arts and Sciences.
    Haikola, Simon
    Linköping University, Department of Thematic Studies, Technology and Social Change. Linköping University, Faculty of Arts and Sciences. Linköping University, Centre for Climate Science and Policy Research, CSPR.
    A multi-level discourse analysis of Swedish wind power resistance, 2009-20222024In: Political Geography, ISSN 0962-6298, E-ISSN 1873-5096, Vol. 108, article id 103017Article in journal (Refereed)
    Abstract [en]

    Wind power production is expanding globally and with this comes social resistance. In this article, we study controversies concerning the expansion of wind power in Sweden between 2009 and 2022. To this end, we study national press coverage and local press coverage from Sweden's 290 municipalities. Despite previous studies showing that Swedish people are generally in favour of expanding wind power, our results show that this policy is controversial and often is met with significant local resistance. We identify a clash between two environmental concerns: developing national policies to mitigate the effects of climate change and local opinions calling for the preservation of natural landscapes, which are often coupled with concerns about whether expansion of wind power leads to positive climate effects. We analyse national and local discourses through a multi-level governance perspective, a view that argues Sweden's market-oriented and decentralized wind power planning regime feeds the controversy. In conclusion, the dispersal of power throughout the planning system facilitates scaling up of local resistance to an energy policy issue of national concern, creating significant uncertainty about the expansion of wind power in Sweden.

  • 27.
    Abiyev, Rahib H.
    et al.
    Near East Univ, Turkiye.
    Altabel, Mohamad Ziad
    Near East Univ, Turkiye.
    Darwish, Manal
    Near East Univ, Turkiye.
    Helwan, Abedelkader
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    A Multimodal Transformer Model for Recognition of Images from Complex Laparoscopic Surgical Videos2024In: Diagnostics, ISSN 2075-4418, Vol. 14, no 7, article id 681Article in journal (Refereed)
    Abstract [en]

    The determination of the potential role and advantages of artificial intelligence-based models in the field of surgery remains uncertain. This research marks an initial stride towards creating a multimodal model, inspired by the Video-Audio-Text Transformer, that aims to reduce negative occurrences and enhance patient safety. The model employs text and image embedding state-of-the-art models (ViT and BERT) to assess their efficacy in extracting the hidden and distinct features from the surgery video frames. These features are then used as inputs for convolution-free Transformer architectures to extract comprehensive multidimensional representations. A joint space is then used to combine the text and image features extracted from both Transformer encoders. This joint space ensures that the relationships between the different modalities are preserved during the combination process. The entire model was trained and tested on laparoscopic cholecystectomy (LC) videos encompassing various levels of complexity. Experimentally, a mean accuracy of 91.0%, a precision of 81%, and a recall of 83% were reached by the model when tested on 30 videos out of 80 from the Cholec80 dataset.

  • 28.
    Mauritsson, Karl
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. Univ Skovde, Sweden.
    Jonsson, Tomas
    Linköping University, Department of Physics, Chemistry and Biology, Biology. Linköping University, Faculty of Science & Engineering. Univ Skovde, Sweden.
    A new mechanistic model for individual growth suggests upregulated maintenance costs when food is scarce in an insect2024In: Ecological Modelling, ISSN 0304-3800, E-ISSN 1872-7026, Vol. 491, article id 110703Article in journal (Refereed)
    Abstract [en]

    A growing animal ingests food from the environment and distributes the assimilated energy between chemical energy stored in synthesized biomass and energy spent on metabolic processes, including food processing, maintenance, activity and overhead costs for growth. Under food restriction, the growth rate is usually decreased. However, the extent of this reduction may be influenced by a potential trade -off with maintenance metabolism. The latter seems to be down-regulated under food restriction in some animals and up-regulated in others. Recently, the Maintenance-Growth Model (MGM) was developed for ontogenetic and post-mature growth, including several aspects not considered by common mechanistic growth models, most importantly the division of maintenance costs into non-negotiable and negotiable parts, where the latter can be up- or downregulated under food restriction. Using empirical data, MGM has been calibrated and successfully applied to an insect growing under ad libitum conditions. Here, the model is further calibrated to newly collected individual data for the same species growing under two different regimes of food restriction, complemented with previously collected data for food-limited cohorts. We find that two alternative model scenarios of MGM are able to generate rather good predictions of observed growth under food restriction, assuming either upregulated maintenance or decreased effective assimilation (assimilation minus energy spent on processing and searching food). We find the latter scenario least plausible, implying that the current study provides the first indication for the occurrence of upregulated maintenance in an insect species when food is scarce, an unexpected result that requires further investigation. The inclusion of maintenance regulation in MGM enables the new growth model to be used in the modelling of life-history dependent trade-offs between maintenance, growth and maturation for various other species.

  • 29.
    Deng, Xuefan
    et al.
    Hubei Univ Sci & Technol, Peoples R China; Wuhan Univ, Peoples R China.
    Xia, Shiying
    Wuhan Univ, Peoples R China.
    Zhao, Haixu
    Wuhan Univ, Peoples R China.
    Wang, Jiajia
    Wuhan Univ, Peoples R China.
    Wang, Zhengxi
    Hubei Univ Sci & Technol, Peoples R China.
    Kuklin, Artem
    Uppsala Univ, Sweden.
    Agren, Hans
    Uppsala Univ, Sweden.
    Baryshnikov, Glib
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Zhang, Haibo
    Wuhan Univ, Peoples R China.
    A new strategy for boron cluster-based metal boride (Co2B) synthesis and its applicability to electrocatalytic nitrate reduction2024In: Chemical Engineering Journal, ISSN 1385-8947, E-ISSN 1873-3212, Vol. 485, article id 149639Article in journal (Refereed)
    Abstract [en]

    To achieve efficient conversion of nitrate to ammonia, it is necessary to design and develop electrode materials with high activity and efficiency for the electrocatalytic reduction reaction of nitrate (NO3RR). Due to its unique semi-metallic properties, the vacancy orbitals of boron are prone to accommodate electrons, so doping element B with transition metals is expected to change the local electronic configuration of the metal, which in turn affects the corresponding catalytic reaction. Here, we propose a new strategy for the preparation of metal borides by using dodecahydro-closo-dodecaborate and Co2+ complexed and calcined to prepare a novel metal boride-Co2B for electrocatalytic nitrate reduction. This modification considerably enhances the performance of NO3RR. Co2B exhibited a Faradaic efficiency of NH4+ (FENH4+) as high as 96.61 % at -0.5 V vs. RHE, achieving a remarkable NH4+ yield of 5.73 mg h-1 mgcat - 1. This study provides a new approach for designing catalysts for environmentallyfriendly ammonia synthesis.

  • 30.
    Augustsson, Cecilia
    et al.
    Univ & Reg Labs Reg Skane, Sweden.
    Taxbro, Knut
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry and Pharmacology. Linköping University, Faculty of Medicine and Health Sciences. Ryhov Cty Hosp, Sweden.
    Strandberg, Karin
    Univ & Reg Labs Reg Skane, Sweden.
    Zetterberg, Eva
    Skane Univ Hosp, Sweden; Lund Univ, Sweden.
    A nonneutralizing antibody as cause of prothrombin deficiency in a patient with follicular lymphoma2024In: Clinical Case Reports, E-ISSN 2050-0904, Vol. 12, no 1, article id e8400Article in journal (Refereed)
    Abstract [en]

    Acquired inhibitors of blood coagulation are rare but of clinical importance. Prothrombin is a vitamin K-dependent protein, and acquired antibodies toward prothrombin are often associated with the presence of lupus anticoagulant. We describe a previously healthy 70-year-old man presenting with both hemorrhage and thrombosis as well as a prolonged prothrombin time. At arrival at the hospital, he was diagnosed with deep venous thrombosis, and an enlarged lymph node in the left groin was noted (revealed as follicular lymphoma grade 1 by biopsy). Prothrombin activity and antibody titer were followed for 5 months with 15 sampling time points to monitor the treatment outcome of the patient. Diagnostic work-up identified prothrombin deficiency as cause of bleeding. A nonneutralizing calcium-dependent antiprothrombin antibody was found, suspected to increase the clearance of prothrombin, which has previously only occasionally been reported. Lupus anticoagulant was ruled out and thrombosis was judged to be caused by a combination of malignant disease and stagnant venous flow following enlarged lymph nodes in the groin. This report illustrates how investigation of prolonged global coagulation tests, triggered the diagnosis of a rare but critical condition, immune-mediated prothrombin deficiency. The diagnosis is challenging and involves proper differential diagnosis. image

  • 31.
    Nguyen, Hoang
    et al.
    Linköping University, Department of Management and Engineering, Production Economics. Linköping University, Faculty of Science & Engineering.
    Osterholm, Par
    Orebro Univ, Sweden; Natl Inst Econ Res, Sweden; Univ Sydney, Australia.
    A note on the dynamic effects of supply and demand shocks in the crude oil market2024In: Applied Economics Letters, ISSN 1350-4851, E-ISSN 1466-4291Article in journal (Refereed)
    Abstract [en]

    In this paper, we investigate whether key relations in the crude oil market have been stable over time. This is done by estimating hybrid time-varying parameter structural Bayesian VAR models using monthly data ranging from February 1973 to May 2023. Model selection suggests that while stochastic volatility is preferred over homoscedasticity, the dynamics of the model are best described by constant parameters in all equations.

  • 32.
    Rodrigues Oliveira, Helena
    et al.
    Centro Federal de Educação Tecnológica Celso Suckow da Fonseca; Programa de Pós-Graduação em Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro, Unidade Multiusuário de Análises Ambientais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Mendes Anacleto, Thuane
    Programa de Pós-Graduação em Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro; Unidade Multiusuário de Análises Ambientais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Carraro, Giacomo
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Linköping University, Biogas Solutions Research Center.
    Abreu, Fernanda
    Programa de Pós-Graduação em Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro; Unidade Multiusuário de Análises Ambientais, Universidade Federal do Rio de Janeiro; Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Enrich Prast, Alex
    Linköping University, Department of Thematic Studies, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences. Unidade Multiusuário de Análises Ambientais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Institute of Marine Science, Federal University of São Paulo (IMar/UNIFESP), Santos, Brazil.
    A novel approach to estimate methanogenic pathways in biogas reactors via stable carbon isotope analysis2024In: Biomass and Bioenergy, ISSN 0961-9534, E-ISSN 1873-2909, Vol. 183, article id 107167Article in journal (Refereed)
    Abstract [en]

    Two microbial pathways are responsible for most of the methane produced during anaerobic digestion: acetoclastic methanogenesis (AM) and hydrogenotrophic methanogenesis (HM) coupled with syntrophic acetate oxidation (SAO). Identifying the dominant methanogenic pathway active in a system provides the information necessary to manage and optimize productivity, stability, process control, and gas quality in biogas reactors. In this study, a modified method is proposed to estimate methanogenic pathways in different biogas systems via short-term parallel incubations with methyl-labeled acetate (2-13C-acetate). Cavity ring-down spectroscopy was applied to measure the δ13C–CH4 and δ13C–CO2 isotopic signatures of produced biogas. Preliminary experiments demonstrated that longer incubation times led to significant variations in δ13C–CH4 and δ13C–CO2 and consequently interfered with the calculated fraction of CH4 produced from HM (fHM). This variability is likely caused by the dilution of 13CH4 and 13CO2 as 2-13C-acetate is consumed, along with potential changes in organic matter quality and quantity, microbial community composition, and environmental factors such as pH, volatile fatty acid content, and ammonia levels, during longer incubations. We applied this new approach to sludge from six full-scale reactors (three mesophilic and three thermophilic) and validated its potential with consistent estimates of fHM with minimal variation. Mesophilic reactors exhibited AM dominance, while HM was the dominant pathway in thermophilic reactors, aligning with reports in the literature.

  • 33.
    Mann, Frank D.
    et al.
    Program in Public Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA; Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
    Cuevas, Adolfo G.
    Department of Social and Behavioral Sciences Department, School of Global Public Health at New York University, Manhattan, NY, USA.
    Clouston, Sean A.P.
    Program in Public Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA; Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
    Freilich, Colin D.
    Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
    Krizan, Zlatan
    Department of Psychology, Iowa State University, Ames, IA, USA.
    Zuber, Sascha
    Institute of Aging and Lifelong Health, University of Victoria, Victoria, BC, V8N 1V8, Canada; Geneva Aging Research Center at University of Geneva, Geneva, Switzerland.
    Wänström, Linda
    Linköping University, Department of Computer and Information Science, The Division of Statistics and Machine Learning. Linköping University, Faculty of Arts and Sciences.
    Muniz-Terrera, Graciela
    Ohio University Heritage College of Osteopathic Medicine (OUHCOM), Dublin, OH, 43016, USA; Edinburgh Dementia Prevention, University of Edinburgh, Edinburgh, EH4 2XU, UK.
    O'Keefe, Patrick
    Department of Neurology, Oregon Health and Science University, Portland, OR, 97239, USA.
    Voll, Stacey
    Institute of Aging and Lifelong Health, University of Victoria, Victoria, BC, V8N 1V8, Canada.
    Hofer, Scott
    Department of Neurology, Oregon Health and Science University, Portland, OR, 97239, USA; Institute of Aging and Lifelong Health, University of Victoria, Victoria, BC, V8N 1V8, Canada.
    Rodgers, Joseph L.
    Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, 37232, USA.
    Krueger, Robert F.
    Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
    A novel approach to model cumulative stress: Area under the s-factor curve2024In: Social Science and Medicine, ISSN 0277-9536, E-ISSN 1873-5347, Vol. 348, article id 116787Article in journal (Refereed)
    Abstract [en]

     Objective:  Using a large longitudinal sample of adults from the Midlife in the United States (MIDUS) study, the present study extended a recently developed hierarchical model to determine how best to model the accumulation of stressors, and to determine whether the rate of change in stressors or traditional composite scores of stressors are stronger predictors of health outcomes.

     Method:  We used factor analysis to estimate a stress-factor score and then, to operationalize the accumulation of stressors we examined five approaches to aggregating information about repeated exposures to multiple stressors. The predictive validity of these approaches was then assessed in relation to different health outcomes.

     Results:  The prediction of chronic conditions, body mass index, difficulty with activities of daily living, executive function, and episodic memory later in life was strongest when the accumulation of stressors was modeled using total area under the curve (AUC) of estimated factor scores, compared to composite scores that have traditionally been used in studies of cumulative stress, as well as linear rates of change.

     Conclusions:  Like endogenous, biological markers of stress reactivity, AUC for individual trajectories of self-reported stressors shows promise as a data reduction technique to model the accumulation of stressors in longitudinal studies. Overall, our results indicate that considering different quantitative models is critical to understanding the sequelae and predictive power of psychosocial stressors from midlife to late adulthood.

  • 34.
    Hussien, Abdelazim
    et al.
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering. Fayoum Univ, Egypt.
    Pop, Adrian
    Linköping University, Department of Computer and Information Science, Software and Systems. Linköping University, Faculty of Science & Engineering.
    Kumar, Sumit
    Univ Tasmania, Australia.
    Hashim, Fatma A.
    Helwan Univ, Egypt; Middle East Univ, Jordan.
    Hu, Gang
    Xian Univ Technol, Peoples R China.
    A Novel Artificial Electric Field Algorithm for Solving Global Optimization and Real-World Engineering Problems2024In: BIOMIMETICS, ISSN 2313-7673, Vol. 9, no 3, article id 186Article in journal (Refereed)
    Abstract [en]

    The Artificial Electric Field Algorithm (AEFA) stands out as a physics-inspired metaheuristic, drawing inspiration from Coulomb's law and electrostatic force; however, while AEFA has demonstrated efficacy, it can face challenges such as convergence issues and suboptimal solutions, especially in high-dimensional problems. To overcome these challenges, this paper introduces a modified version of AEFA, named mAEFA, which leverages the capabilities of Levy flights, simulated annealing, and the Adaptive s-best Mutation and Natural Survivor Method (NSM) mechanisms. While Levy flights enhance exploration potential and simulated annealing improves search exploitation, the Adaptive s-best Mutation and Natural Survivor Method (NSM) mechanisms are employed to add more diversity. The integration of these mechanisms in AEFA aims to expand its search space, enhance exploration potential, avoid local optima, and achieve improved performance, robustness, and a more equitable equilibrium between local intensification and global diversification. In this study, a comprehensive assessment of mAEFA is carried out, employing a combination of quantitative and qualitative measures, on a diverse range of 29 intricate CEC'17 constraint benchmarks that exhibit different characteristics. The practical compatibility of the proposed mAEFA is evaluated on five engineering benchmark problems derived from the civil, mechanical, and industrial engineering domains. Results from the mAEFA algorithm are compared with those from seven recently introduced metaheuristic algorithms using widely adopted statistical metrics. The mAEFA algorithm outperforms the LCA algorithm in all 29 CEC'17 test functions with 100% superiority and shows better results than SAO, GOA, CHIO, PSO, GSA, and AEFA in 96.6%, 96.6%, 93.1%, 86.2%, 82.8%, and 58.6% of test cases, respectively. In three out of five engineering design problems, mAEFA outperforms all the compared algorithms, securing second place in the remaining two problems. Results across all optimization problems highlight the effectiveness and robustness of mAEFA compared to baseline metaheuristics. The suggested enhancements in AEFA have proven effective, establishing competitiveness in diverse optimization problems.

  • 35.
    Elovsson, Greta
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Klingstedt, Therése
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Brown, Mikaela
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Nilsson, Peter
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Brorsson, Ann-Christin
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    A Novel <i>Drosophila</i> Model of Alzheimer's Disease to Study Aß Proteotoxicity in the Digestive Tract2024In: International Journal of Molecular Sciences, ISSN 1661-6596, E-ISSN 1422-0067, Vol. 25, no 4, article id 2105Article in journal (Refereed)
    Abstract [en]

    Amyloid-beta (A beta) proteotoxicity is associated with Alzheimer's disease (AD) and is caused by protein aggregation, resulting in neuronal damage in the brain. In the search for novel treatments, Drosophila melanogaster has been extensively used to screen for anti-A beta proteotoxic agents in studies where toxic A beta peptides are expressed in the fly brain. Since drug molecules often are administered orally there is a risk that they fail to reach the brain, due to their inability to cross the brain barrier. To circumvent this problem, we have designed a novel Drosophila model that expresses the A beta peptides in the digestive tract. In addition, a built-in apoptotic sensor provides a fluorescent signal from the green fluorescent protein as a response to caspase activity. We found that expressing different variants of A beta 1-42 resulted in proteotoxic phenotypes such as reduced longevity, aggregate deposition, and the presence of apoptotic cells. Taken together, this gut-based A beta-expressing fly model can be used to study the mechanisms behind A beta proteotoxicity and to identify different substances that can modify A beta proteotoxicity.

  • 36.
    Abuhasanein, Suleiman
    et al.
    Univ Gothenburg, Sweden; NU Hosp Grp, Sweden.
    Edenbrandt, Lars
    Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden.
    Enqvist, Olof
    Chalmers Univ Technol, Sweden; Eigenvision AB, Sweden.
    Jahnson, Staffan
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
    Leonhardt, Henrik
    Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden.
    Traegardh, Elin
    Lund Univ, Sweden; Skane Univ Hosp, Sweden.
    Ulen, Johannes
    Eigenvision AB, Sweden; Univ Gothenburg, Sweden.
    Kjoelhede, Henrik
    Univ Gothenburg, Sweden; Sahlgrens Univ Hosp, Sweden.
    A novel model of artificial intelligence based automated image analysis of CT urography to identify bladder cancer in patients investigated for macroscopic hematuria2024In: Scandinavian journal of urology, ISSN 2168-1805, E-ISSN 2168-1813, Vol. 59, p. 90-97Article in journal (Refereed)
    Abstract [en]

    Objective: To evaluate whether artificial intelligence (AI) based automatic image analysis utilising convolutional neural networks (CNNs) can be used to evaluate computed tomography urography (CTU) for the presence of urinary bladder cancer (UBC) in patients with macroscopic hematuria. Methods: Our study included patients who had undergone evaluation for macroscopic hematuria. A CNN-based AI model was trained and validated on the CTUs included in the study on a dedicated research platform (Recomia.org). Sensitivity and specificity were calculated to assess the performance of the AI model. Cystoscopy findings were used as the reference method. Results: The training cohort comprised a total of 530 patients. Following the optimisation process, we developed the last version of our AI model. Subsequently, we utilised the model in the validation cohort which included an additional 400 patients (including 239 patients with UBC). The AI model had a sensitivity of 0.83 (95% confidence intervals [CI], 0.76-0.89), specificity of 0.76 (95% CI 0.67-0.84), and a negative predictive value (NPV) of 0.97 (95% CI 0.95-0.98). The majority of tumours in the false negative group (n = 24) were solitary (67%) and smaller than 1 cm (50%), with the majority of patients having cTaG1-2 (71%). Conclusions: We developed and tested an AI model for automatic image analysis of CTUs to detect UBC in patients with macroscopic hematuria. This model showed promising results with a high detection rate and excessive NPV. Further developments could lead to a decreased need for invasive investigations and prioritising patients with serious tumours.

  • 37.
    Podéus, Henrik
    et al.
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    Simonsson, Christian
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Nasr, Patrik
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Mag- tarmmedicinska kliniken.
    Ekstedt, Mattias
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Mag- tarmmedicinska kliniken. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Kechagias, Stergios
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Mag- tarmmedicinska kliniken.
    Lundberg, Peter
    Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Medical radiation physics. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Lövfors, William
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Orebro Univ, Sweden.
    Cedersund, Gunnar
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV). Orebro Univ, Sweden.
    A physiologically-based digital twin for alcohol consumption-predicting real-life drinking responses and long-term plasma PEth2024In: npj Digital Medicine, E-ISSN 2398-6352, Vol. 7, no 1, article id 112Article in journal (Refereed)
    Abstract [en]

    Alcohol consumption is associated with a wide variety of preventable health complications and is a major risk factor for all-cause mortality in the age group 15-47 years. To reduce dangerous drinking behavior, eHealth applications have shown promise. A particularly interesting potential lies in the combination of eHealth apps with mathematical models. However, existing mathematical models do not consider real-life situations, such as combined intake of meals and beverages, and do not connect drinking to clinical markers, such as phosphatidylethanol (PEth). Herein, we present such a model which can simulate real-life situations and connect drinking to long-term markers. The new model can accurately describe both estimation data according to a chi 2 -test (187.0 &lt; T-chi 2 = 226.4) and independent validation data (70.8 &lt; T-chi 2 = 93.5). The model can also be personalized using anthropometric data from a specific individual and can thus be used as a physiologically-based digital twin. This twin is also able to connect short-term consumption of alcohol to the long-term dynamics of PEth levels in the blood, a clinical biomarker of alcohol consumption. Here we illustrate how connecting short-term consumption to long-term markers allows for a new way to determine patient alcohol consumption from measured PEth levels. An additional use case of the twin could include the combined evaluation of patient-reported AUDIT forms and measured PEth levels. Finally, we integrated the new model into an eHealth application, which could help guide individual users or clinicians to help reduce dangerous drinking.

  • 38.
    Chen, Jiyao
    et al.
    Oregon State Univ, USA.
    Zhang, Stephen X.
    Univ Adelaide, Australia.
    Lundmark, Erik
    Linköping University, Department of Management and Engineering, Project Innovations and Entrepreneurship. Linköping University, Faculty of Science & Engineering. Macquarie Univ, Australia.
    A Quantum view of entrepreneurial opportunity: moving beyond the Discovery and Creation views2024In: Small Business Economics, ISSN 0921-898X, E-ISSN 1573-0913Article in journal (Refereed)
    Abstract [en]

    This article sheds new light on the debate between the Discovery and Creation views of entrepreneurial opportunity by drawing on quantum theory. We develop the Quantum view of opportunity, which explains how opportunity is both discovered and created. The Quantum view holds that the ontology and epistemology of opportunity are fundamentally inseparable, which explains why opportunity can never be fully specified. We argue, similar to the Discovery view, that opportunity exists as latent states irrespective of entrepreneurs and that, similar to the Creation view, opportunity is instantiated through entrepreneurial action, which changes opportunity. We use the Quantum view as a thought-provoking metaphor that facilitates the breaking out of the mold of ingrained thinking and moves beyond the Discovery-Creation dichotomy to further our understanding of entrepreneurship. We discuss how the Quantum view relates to established theoretical and empirical research in the entrepreneurship field. Rethinking Entrepreneurial Opportunity: A Quantum view! Discover how opportunities are both found and made. #QuantumOpportunity. Entrepreneurial opportunities have long been debated: are they discovered or created? Inspired by quantum mechanics, this article introduces a fresh perspective called the "Quantum view." Instead of seeing opportunities as either discovered or created, the Quantum view suggests that they are both created and discovered. It urges us to rethink conventional wisdom. Instead of just "finding" or "making" opportunities, the Quantum view suggests that opportunities exist in potential states and are realized through entrepreneurial enactment. Entrepreneurs can gather information about opportunities, but they can never fully specify them because every time they interact with an opportunity, they change it. Thus, the Quantum view emphasizes that we can learn about, but never fully specify, opportunities. This helps researchers think differently about opportunities and avoid extreme positions such as that entrepreneurs create something from nothing or that some entrepreneurs can accurately predict the future.

    Download full text (pdf)
    fulltext
  • 39.
    Forsling, Robin
    et al.
    Saab Aeronaut, S-58188 Linkoping, Sweden.
    Noack, Benjamin
    KIT, Germany; Otto von Guericke Univ OVGU Magdeburg, Germany.
    Hendeby, Gustaf
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, Faculty of Science & Engineering. German Res Ctr Artificial Intelligence DFKI, Germany; Swedish Def Res Agcy FOI, Sweden.
    A Quarter Century of Covariance Intersection: Correlations Still Unknown? [Lecture Notes]2024In: IEEE CONTROL SYSTEMS MAGAZINE, ISSN 1066-033X, Vol. 44, no 2, p. 81-105Article in journal (Refereed)
    Abstract [en]

    Over the past two and a half decades, covariance intersection (CI) has provided a means for robust estimation in scenarios where the uncertainty information is incomplete. Estimation in distributed and decentralized data fusion (DDF) settings is typically characterized by having nonzero cross-correlations between the estimates to be merged. Mean-square-error (MSE) optimal estimators, such as the Kalman filter (KF), are limited to data fusion problems where these cross-correlations are fully known. Keeping track of cross-correlations is unfortunately not always possible. To quantify confidence in the estimate's uncertainty, the concept of conservativeness has been introduced. A conservative estimator guarantees that the computed covariance matrix is not smaller than the actual covariance matrix. It turns out that CI guarantees conservativeness for any degree of unknown cross-correlations as long as the estimates to be fused are conservative. It should be noted that, in the CI literature, the notion of covariance consistency is often used to characterize conservativeness. In this work, we use the latter term.

  • 40.
    Eneholm, Johan
    et al.
    Linköping University, Department of Biomedical and Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
    Beka, Ervin
    Linköping University, Department of Biomedical and Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
    Kotán, Róbert
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
    Gimm, Oliver
    Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping. Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology.
    A retrospective study comparing minimally invasive versus open surgical resection of small intestinal neuroendocrine neoplasms at a tertiary referral center2024In: European Journal of Surgical Oncology, ISSN 0748-7983, E-ISSN 1532-2157, Vol. 50, no 2, article id 107936Article in journal (Refereed)
    Abstract [en]

    Introduction: Neuroendocrine neoplasms (SI-NEN) are the commonest malignancies of the small intestine. Traditionally, surgical treatment for SI-NEN has been open surgery.

    Purpose: The purpose of this study was to compare minimally invasive surgery (MIS) with the traditional open surgery approach for treating SI-NEN in a Swedish population.

    Methods: Patients with histopathological confirmed SI-NEN who underwent open surgery or MIS resection within 2009-2021 were extracted from the hospital's medical records.

    Results: 65 patients were included in this study, with 35 (54 %) undergoing MIS and 30 (46 %) undergoing open surgery. We found no statistically significant difference (p = 0.173) in the frequency of R0 resections (MIS group n = 34 (97 %), open surgery group n = 26 (87 %)). Nor was there a significant difference (p = 0.101) when comparing the median number of resected lymph nodes (MIS group n = 13.5, open surgery group n = 10). A post-operative paralytic ileus was more often reported (p = 0.052) in the MIS group (n = 9, 26 %) compared to the open surgery group (n = 2, 7 %). In light of this, the days of hospital stay did not differ significantly (MIS group median = 6, IQR (5-8), open surgery group median = 6, IQR (5-9)). The Kaplan-Meier analysis did not reveal differences concerning cancer-related deaths (p = 0.109).

    Conclusion: The results from this study support that a MIS approach for the treatment of SI-NEN may not be inferior to open surgery. The higher number of resected lymph nodes and R0 resections may even speak in favor for a MIS approach. More studies with a longer time of observation are needed to further support this conclusion.

    Download full text (pdf)
    fulltext
  • 41.
    Pataki, Nathan James
    et al.
    Ist Italiano Tecnol, Italy; Politecn Milan, Italy.
    Zahabi, Najmeh
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Li, Qifan
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Rossi, Pietro
    Ist Italiano Tecnol, Italy; Politecn Milan, Italy.
    Cassinelli, Marco
    Ist Italiano Tecnol, Italy.
    Butti, Matteo
    Ist Italiano Tecnol, Italy.
    Massetti, Matteo
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Fabiano, Simone
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Zozoulenko, Igor
    Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.
    Caironi, Mario
    Ist Italiano Tecnol, Italy.
    A Rolled Organic Thermoelectric Generator with High Thermocouple Density2024In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, article id 2400982Article in journal (Refereed)
    Abstract [en]

    The surge in the number of distributed microelectronics and sensors requires versatile, scalable, and affordable power sources. Heat-harvesting organic thermoelectric generators (TEGs) are regarded as potential key components of the future energy landscape. Recent advances in the performance of organic thermoelectric materials have made practical applications of organic TEGs more feasible than ever before, yet the challenges of designing and fabricating organic TEGs suitable for real scenarios are scarcely addressed. Specifically, small sensors and wearables demand for micro-thermoelectric generators (mu TEGs) with high power density architectures and small form factors, while typical demonstrations of organic TEGs are characterized by &lt; 10 thermocouples (TCs) per cm(2). This work presents a rolled, organic mu TEG architecture combining large-area, solution-based deposition techniques, such as inkjet and spray-coating, and an ultrathin parylene substrate to achieve a thermocouple density of 1842 TCs cm(-2). Such demonstrative mu TEG reaches a thermoelectric conversion performance of 0.15 mu W cm(-2) at Delta T = 50 K. Such power output is well in line with finite element method simulations, which highlight the benefit of the architecture and show that remarkable power densities, in the mW cm(-2) range at Delta T = 10 K, are realistically achievable with geometrical improvements and already ongoing advancements in organic thermoelectric inks.

  • 42.
    Bjarehed, Marlene
    et al.
    Kristianstad Univ, Sweden.
    Sjögren, Björn
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Thornberg, Robert
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Gini, Gianluca
    Univ Padua, Italy.
    Pozzoli, Tiziana
    Univ Padua, Italy.
    A short-term longitudinal study on the development of moral disengagement among schoolchildren: the role of collective moral disengagement, authoritative teaching, and student-teacher relationship quality2024In: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 15, article id 1381015Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to examine whether collective moral disengagement and authoritative teaching at the classroom level, and student-teacher relationship quality at the individual level, predicted individual moral disengagement among pre-adolescent students 1 year later. In this short-term longitudinal study, 1,373 students from 108 classrooms answered a web-based questionnaire on tablets during school, once in fifth grade (T1) and once in sixth grade (T2). The results showed, after controlling for T1 moral disengagement, gender, and immigrant background, that students with better student-teacher relationship quality at T1 were more inclined to score lower on moral disengagement at T2, whereas students in classrooms with higher levels of collective moral disengagement at T1 were more inclined to score higher on moral disengagement at T2. In addition, both collective moral disengagement and authoritative teaching were found to moderate the associations between student-teacher relationship quality at T1 and moral disengagement at T2. These findings underscore the importance of fostering positive relationships between students and teachers, as well as minimizing collective moral disengagement in classrooms. These measures may prevent the potential escalation of moral disengagement in a negative direction.

  • 43.
    Vega-Sanchez, Jose David
    et al.
    Univ Las Amer, Ecuador.
    Urquiza-Aguiar, Luis
    Escuela Politec Nacl, Ecuador.
    Paredes, Martha Cecilia Paredes
    Escuela Politec Nacl, Ecuador.
    Moya Osorio, Diana
    Linköping University, Department of Electrical Engineering, Communication Systems. Linköping University, Faculty of Science & Engineering. Univ Oulu, Finland.
    A Simple Method for the Performance Analysis of Fluid Antenna Systems Under Correlated Nakagami-<i>m</i> Fading2024In: IEEE Wireless Communications Letters, ISSN 2162-2337, E-ISSN 2162-2345, Vol. 13, no 2, p. 377-381Article in journal (Refereed)
    Abstract [en]

    By recognizing the tremendous flexibility of the emerging fluid antenna system (FAS), which allows dynamic reconfigurability of the location of the antenna within a given space, this letter investigates the performance of a single-antenna FAS over spatially correlated Nakagami- ${m}$ fading channels. Specifically, simple and highly accurate closed-form approximations for the cumulative density function of the FAS channel and the outage probability of the proposed system are obtained by employing a novel asymptotic matching method, which is an improved version of the well-known moment matching. With this method, the outage probability can be computed simply without incurring complex multi-fold integrals, thus requiring negligible computational effort. Finally, the accuracy of the proposed approximations is validated, and it is shown that the FAS can meet or even exceed the performance attained by the conventional maximal ratio combining (MRC) technique.

  • 44.
    Nordström, Jan
    Linköping University, Department of Mathematics, Applied Mathematics. Linköping University, Faculty of Science & Engineering. Department of Mathematics and Applied Mathematics, University of Johannesburg, Johannesburg, South Africa.
    A skew-symmetric energy stable almost dissipation free formulation of the compressible Navier-Stokes equations2024In: Journal of Computational Physics, ISSN 0021-9991, E-ISSN 1090-2716, Vol. 512, article id 113145Article in journal (Refereed)
    Abstract [en]

    We show that a specific skew-symmetric formulation of the nonlinear terms in the compressible Navier-Stokes equations leads to an energy rate in terms of surface integrals only. No dissipative volume integrals contribute to the energy rate. We also discuss boundary conditions that bounds the surface integrals.

    Download full text (pdf)
    fulltext
  • 45.
    Käck, Elin
    Linköping University, Department of Culture and Society, Division of Language, Culture and Interaction. Linköping University, Faculty of Arts and Sciences.
    A Spatiotemporal Collage Aesthetic: Poets and Poetry in Siri Hustvedt's Memories of the Future2024In: Journal of Modern Literature, ISSN 0022-281X, E-ISSN 1529-1464, Vol. 47, no 2, p. 82-97Article in journal (Refereed)
    Abstract [en]

    In the structurally and thematically elaborate novel Memories of the Future (2019), Siri Hustvedt foregrounds the relationship between poetry and the novel. Two poets stand out as especially important to matters of plot, theme, and narrative: the modernist avant-garde poet Elsa von Freytag-Loringhoven and the New York School poet John Ashbery. These poets belong to different, but similarly pivotal moments in the evolution of American literature, one being a prescient—now recognized as iconic—modernist and the other an established, leading postmodernist. Despite their many differences, their output within poetry and the arts point to a collage aesthetics that provides a new way of probing the relationship between poetry and prose, as well as to a focus on the Bakhtinian notions of dialogism, polyphony, and voice, which inform the novel's structure and themes.

  • 46.
    Rudolf, F.
    et al.
    INDEPTH Network, Guinea Bissau; Aarhus Univ Hosp, Denmark; Aarhus Univ Hosp, Denmark.
    Abate, E.
    Ethiopian Publ Hlth Inst, Ethiopia; Univ Gondar, Ethiopia.
    Moges, B.
    Gomes, V. F.
    INDEPTH Network, Guinea Bissau; Minist Saude, Guinea Bissau.
    Mendes, A. M.
    INDEPTH Network, Guinea Bissau.
    Sifna, A.
    INDEPTH Network, Guinea Bissau; Minist Saude, Guinea Bissau.
    Fekadu, H.
    Univ Gondar, Ethiopia.
    Bizuneh, S.
    Univ Gondar, Ethiopia.
    Wejse, C.
    INDEPTH Network, Guinea Bissau; Aarhus Univ Hosp, Denmark; Aarhus Univ, Denmark.
    Schön, Thomas
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Diagnostics, Department of Clinical Microbiology.
    A structured 2-week follow-up visit in the cascade of care for TB increases case detection2024In: The International Journal of Tuberculosis and Lung Disease, ISSN 1027-3719, E-ISSN 1815-7920, Vol. 28, no 3, p. 148-153Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: Delayed detection in TB due to structural and diagnostic shortcomings is pivotal for disease transmission, morbidity and mortality. We investigated whether an inclusive screening, followed by a structured clinical follow-up (FU) could improve case -finding. METHODS: Patients were recruited from health centres in Bissau, Guinea-Bissau, and Gondar, Ethiopia. A routine FU was done at Week 2. If persisting symptoms were found, patients were investigated using chest X-ray (CXR) and Xpert (R) MTB/RIF, followed by a medical consultation. The main outcome were additional TB patients diagnosed by applying the FU strategy. RESULTS: Of 3,571 adults, 3,285 (95%) were examined at Week 2 FU, where 2,491 (72%) were asymptomatic. Screening patients presenting with cough &gt; 2 weeks alone contributed to the diagnosis of 93 patients (45% of all patients diagnosed here), whereas a TBscore &gt; 3 increased this by 18 (9%); adding a Week 2 FU yielded an additional 94 (46%) patients. Among the 794 (24%) with persisting symptoms, 25 were diagnosed using Xpert and 69 at clinical FU, which constituted 46% (94/205) of the total TB patients diagnosed. CONCLUSION: A Week 2 FU visit, which can be nested into routine healthcare, increased the diagnosis of TB patients by two -fold and avoids diagnostic gaps in the cascade -of -care.

  • 47.
    Ni, Zhongjun
    et al.
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    Zhang, Chi
    University of Gothenburg, Sweden.
    Karlsson, Magnus
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    Gong, Shaofang
    Linköping University, Department of Science and Technology, Physics, Electronics and Mathematics. Linköping University, Faculty of Science & Engineering.
    A study of deep learning-based multi-horizon building energy forecasting2024In: Energy and Buildings, ISSN 0378-7788, E-ISSN 1872-6178, Vol. 303, article id 113810Article in journal (Refereed)
    Abstract [en]

    Building energy forecasting facilitates optimizing daily operation scheduling and long-term energy planning. Many studies have demonstrated the potential of data-driven approaches in producing point forecasts of energy use. Despite this, little work has been undertaken to understand uncertainty in energy forecasts. However, many decision-making scenarios require information from a full conditional distribution of forecasts. In addition, recent advances in deep learning have not been fully exploited for building energy forecasting. Motivated by these research gaps, this study contributes in two aspects. First, this study has adapted and applied state-of-the-art deep learning architectures to address the problem of multi-horizon building energy forecasting. Eight different methods, including seven deep learning-based ones, were investigated to develop models to perform both point and probabilistic forecasts. Second, a comprehensive case study was conducted in two public historic buildings with different operating modes, namely the City Museum and the City Theatre, in Norrköping, Sweden. The performance of the developed models was evaluated, and the predictability of different scenarios of energy consumption was studied. The results show that incorporating future information on exogenous factors that determine energy use is critical for making accurate multi-horizon predictions. Furthermore, changes in the operating mode and activities held in a building bring more uncertainty in energy use and deteriorate the prediction accuracy of models. The temporal fusion transformer (TFT) model exhibited strong competitiveness in performing both point and probabilistic forecasts. As assessed by the coefficient of variance of the root mean square error (CV-RMSE), the TFT model outperformed other models in making point forecasts of both types of energy use of the City Museum (CV-RMSE 29.7% for electricity consumption and CV-RMSE 8.7% for heating load). When making probabilistic predictions, the TFT model performed best to capture the central tendency and upper distribution of heating load of the City Museum as well as both types of energy use of the City Theatre. The predictive models developed in this study can be integrated into digital twin models of buildings to discover areas where energy use can be reduced, optimize building operations, and improve overall sustainability and efficiency.

    Download full text (pdf)
    fulltext
  • 48.
    Chai, Guocai
    Linköping University, Department of Management and Engineering, Engineering Materials. Linköping University, Faculty of Science & Engineering. Alleima AB, Sweden.
    A study on fatigue damage and crack initiation in austenitic steel matrix during very high cycle fatigue2024In: International Journal of Fatigue, ISSN 0142-1123, E-ISSN 1879-3452, Vol. 179, article id 108033Article in journal (Refereed)
    Abstract [en]

    Fatigue damage and crack initiation behavior has been studied in an austenitic stainless steel using a novel progressive stepwise load increasing method with a cycle step greater than 108 cycles and investigated with a FIB-SEM. Subsurface crack origin with a fine granular area in the matrix was formed. Heterogeneous plastic deformation causes strain localization and grain fragmentation. Localized plasticity exhaustion induces crack initiation. A crack origin is completed once a short crack reaches the stress intensity factor threshold for stage II crack propagation. This study provides a fundamental discussion how damage and crack initiation in matrix occur during very high cycle fatigue.

  • 49.
    Linders, Viktor
    et al.
    Lund University, Sweden.
    Carpenter, Mark H.
    NASA Langley Research Center, USA.
    Nordström, Jan
    Linköping University, Faculty of Science & Engineering. Linköping University, Department of Mathematics, Applied Mathematics. University of Johannesburg, South Africa.
    A superconvergent stencil-adaptive SBP-SAT finite difference scheme2024In: Journal of Computational Physics, ISSN 0021-9991, E-ISSN 1090-2716, Vol. 501, article id 112794Article in journal (Refereed)
    Abstract [en]

    A stencil-adaptive SBP-SAT finite difference scheme is shown to display superconvergent behavior. As proof of concept, applied to the linear advection equation, it has a convergence rate Ox4) in contrast to a conventional scheme, which converges at a rate Ox3).

    Download full text (pdf)
    fulltext
  • 50.
    Lindelof, Linnea
    et al.
    Uppsala Univ, Sweden.
    Rantapaa-Dahlqvist, Solbritt
    Umea Univ, Sweden.
    Lundtoft, Christian
    Uppsala Univ, Sweden.
    Sandling, Johanna K.
    Uppsala Univ, Sweden.
    Leonard, Dag
    Uppsala Univ, Sweden.
    Sayadi, Ahmed
    Uppsala Univ, Sweden.
    Ronnblom, Lars
    Uppsala Univ, Sweden.
    Enocsson, Helena
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Medicine Center, Department of Rheumatology.
    Sjöwall, Christopher
    Linköping University, Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Medicine Center, Department of Rheumatology.
    Jonsen, Andreas
    Lund Univ, Sweden.
    Bengtsson, Anders A.
    Lund Univ, Sweden.
    Hong, Mun-Gwan
    Stockholm Univ, Sweden.
    Diaz-Gallo, Lina-Marcela
    Karolinska Inst, Sweden.
    Bianchi, Matteo
    Uppsala Univ, Sweden.
    Kozyrev, Sergey V
    Uppsala Univ, Sweden.
    Lindblad-Toh, Kerstin
    Uppsala Univ, Sweden; Broad Inst MIT & Harvard, MA USA.
    Ekdahl, Kristina Nilsson
    Uppsala Univ, Sweden; Linnaeus Univ, Sweden.
    Nilsson, Bo
    Uppsala Univ, Sweden.
    Gunnarsson, Iva
    Karolinska Inst, Sweden.
    Svenungsson, Elisabet
    Karolinska Inst, Sweden.
    Eriksson, Oskar
    Uppsala Univ, Sweden.
    A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile2024In: Journal of Autoimmunity, ISSN 0896-8411, E-ISSN 1095-9157, Vol. 143, article id 103166Article in journal (Refereed)
    Abstract [en]

    The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway. Ficolin-3 is the main initiator of the lectin pathway of complement in humans, but its role in systemic autoimmune disease has not been conclusively determined. Here, we combined biochemical and genetic approaches to assess the contribution of ficolin-3 to SLE risk and disease manifestations. Ficolin-3 activity was measured by a functional assay in serum or plasma samples from Swedish SLE patients (n = 786) and controls matched for age and sex (n = 566). Genetic variants in an extended 300 kb genomic region spanning the FCN3 locus were analyzed for their association with ficolin-3 activity and SLE manifestations in a Swedish multicenter cohort (n = 985). Patients with ficolin-3 activity in the highest tertile showed a strong enrichment in an SLE cluster defined by anti-Sm/DNA/nucleosome antibodies (OR 3.0, p &lt; 0.001) and had increased rates of hematological disease (OR 1.4, p = 0.078) and lymphopenia (OR = 1.6, p = 0.039). Genetic variants associated with low ficolin-3 activity mapped to an extended haplotype in high linkage disequilibrium upstream of the FCN3 gene. Patients carrying the lead genetic variant associated with low ficolin3 activity had a lower frequency of hematological disease (OR 0.67, p = 0.018) and lymphopenia (OR 0.63, p = 0.031) and fewer autoantibodies (p = 0.0019). Loss-of-function variants in the FCN3 gene were not associated with SLE, but four (0.5 %) SLE patients developed acquired ficolin-3 deficiency where ficolin-3 activity in serum was depleted following diagnosis of SLE. Taken together, our results provide genetic and biochemical evidence that implicate the lectin pathway in hematological SLE manifestations. We also identify lectin pathway activation through ficolin-3 as a factor that contributes to the autoantibody response in SLE.

1234567 1 - 50 of 75363
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf