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  • 1.
    Gawel, Danuta
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Serra-Musach, Jordi
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Lilja, Sandra
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Aagesen, Jesper
    Reg Jonkoping Cty, Sweden.
    Arenas, Alex
    Univ Rovira and Virgili, Spain.
    Asking, Bengt
    Reg Jonkoping Cty, Sweden.
    Bengner, Malin
    Reg Jonkoping Cty, Sweden.
    Bjorkander, Janne
    Reg Jonkoping Cty, Sweden.
    Biggs, Sophie
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Hjortswang, Henrik
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Magtarmmedicinska kliniken.
    Karlsson, Jan-Erik
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Reg Jonkoping Cty, Sweden.
    Köpsén, Mattias
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Jung Lee, Eun Jung
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Yonsei Univ, South Korea.
    Lentini, Antonio
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Li, Xinxiu
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Magnusson, Mattias
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Martinez, David
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Matussek, Andreas
    Reg Jonkoping Cty, Sweden; Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden.
    Nestor, Colm
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Schafer, Samuel
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten.
    Seifert, Oliver
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten. Reg Jonkoping Cty, Sweden.
    Sonmez, Ceylan
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten.
    Stjernman, Henrik
    Reg Jonkoping Cty, Sweden.
    Tjärnberg, Andreas
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Wu, Simon
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Åkesson, Karin
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Reg Jonkoping Cty, Sweden.
    Shalek, Alex K.
    MIT, MA 02139 USA; Broad Inst MIT and Harvard, MA 02142 USA; Ragon Inst MGH MIT and Harvard, MA USA.
    Stenmarker, Margaretha
    Reg Jonkoping Cty, Sweden; Inst Clin Sci, Sweden.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Gustafsson, Mika
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
    A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases2019Ingår i: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 11, artikel-id 47Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background

    Genomic medicine has paved the way for identifying biomarkers and therapeutically actionable targets for complex diseases, but is complicated by the involvement of thousands of variably expressed genes across multiple cell types. Single-cell RNA-sequencing study (scRNA-seq) allows the characterization of such complex changes in whole organs.

    Methods

    The study is based on applying network tools to organize and analyze scRNA-seq data from a mouse model of arthritis and human rheumatoid arthritis, in order to find diagnostic biomarkers and therapeutic targets. Diagnostic validation studies were performed using expression profiling data and potential protein biomarkers from prospective clinical studies of 13 diseases. A candidate drug was examined by a treatment study of a mouse model of arthritis, using phenotypic, immunohistochemical, and cellular analyses as read-outs.

    Results

    We performed the first systematic analysis of pathways, potential biomarkers, and drug targets in scRNA-seq data from a complex disease, starting with inflamed joints and lymph nodes from a mouse model of arthritis. We found the involvement of hundreds of pathways, biomarkers, and drug targets that differed greatly between cell types. Analyses of scRNA-seq and GWAS data from human rheumatoid arthritis (RA) supported a similar dispersion of pathogenic mechanisms in different cell types. Thus, systems-level approaches to prioritize biomarkers and drugs are needed. Here, we present a prioritization strategy that is based on constructing network models of disease-associated cell types and interactions using scRNA-seq data from our mouse model of arthritis, as well as human RA, which we term multicellular disease models (MCDMs). We find that the network centrality of MCDM cell types correlates with the enrichment of genes harboring genetic variants associated with RA and thus could potentially be used to prioritize cell types and genes for diagnostics and therapeutics. We validated this hypothesis in a large-scale study of patients with 13 different autoimmune, allergic, infectious, malignant, endocrine, metabolic, and cardiovascular diseases, as well as a therapeutic study of the mouse arthritis model.

    Conclusions

    Overall, our results support that our strategy has the potential to help prioritize diagnostic and therapeutic targets in human disease.

  • 2.
    Zhang, Huan
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
    Klareskog, Lars
    Karolinska Inst, Sweden.
    Matussek, Andreas
    Karolinska Univ Hosp Lab, Sweden.
    Pfister, Stefan M.
    Hopp Childrens Canc Ctr Heidelberg KiTZ, Germany; German Canc Res Ctr, Germany; German Canc Consortium DKTK, Germany; Heidelberg Univ Hosp, Germany.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
    Editorial Material: Translating genomic medicine to the clinic: challenges and opportunities in GENOME MEDICINE, vol 11, issue , pp2019Ingår i: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 11, artikel-id 9Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    Editorial summaryGenomic medicine has considerable potential to provide novel diagnostic and therapeutic solutions for patients who have molecularly complex diseases and who are not responding to existing therapies. To bridge the gap between genomic medicine and clinical practice, integration of various data types, resources, and joint international initiatives will be required.

  • 3.
    Lentini, Antonio
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Lagerwall, Cathrine
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Vikingsson, Svante
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten. Natl Board Forens Med, Dept Forens Genet and Forens Toxicol, Linkoping, Sweden.
    Mjoseng, Heidi K.
    Univ Edinburgh, Scotland.
    Douvlataniotis, Dimitrios Karolos
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Vogt, Hartmut
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.
    Green, Henrik
    Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Medicinska fakulteten. Natl Board Forens Med, Dept Forens Genet and Forens Toxicol, Linkoping, Sweden.
    Meehan, Richard R.
    Univ Edinburgh, Scotland.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Nestor, Colm
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    A reassessment of DNA-immunoprecipitation-based genomic profiling2018Ingår i: Nature Methods, ISSN 1548-7091, E-ISSN 1548-7105, Vol. 15, nr 7, s. 499-+Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    DNA immunoprecipitation followed by sequencing (DIP-seq) is a common enrichment method for profiling DNA modifications in mammalian genomes. However, the results of independent DIP-seq studies often show considerable variation between profiles of the same genome and between profiles obtained by alternative methods. Here we show that these differences are primarily due to the intrinsic affinity of IgG for short unmodified DNA repeats. This pervasive experimental error accounts for 50-99% of regions identified as enriched for DNA modifications in DIP-seq data. Correction of this error profoundly altered DNA-modification profiles for numerous cell types, including mouse embryonic stem cells, and subsequently revealed novel associations among DNA modifications, chromatin modifications and biological processes. We conclude that both matched input and IgG controls are essential in order for the results of DIP-based assays to be interpreted correctly, and that complementary, non-antibody-based techniques should be used to validate DIP-based findings to avoid further misinterpretation of genome-wide profiling data.

  • 4.
    Bousquet, J.
    et al.
    University Hospital, France; European Innovat Partnership Act and Health Ageing Re, France; INSERM, France; University of Versailles St Quentin En Yvelines, France.
    Bewick, M.
    iQ4U Consultants Ltd, England.
    Cano, A.
    University of Valencia, Spain.
    Eklund, P.
    Umeå University, Sweden; Four Comp Oy, Finland.
    Fico, G.
    University of Politecn Madrid, Spain.
    Goswami, N.
    Medical University of Graz, Austria.
    Guldemond, N. A.
    University of Medical Centre Utrecht, Netherlands.
    Henderson, D.
    European Innovat Partnership Act and Health Ageing, Scotland.
    Hinkema, M. J.
    TNO, Netherlands.
    Liotta, G.
    University of Roma Tor Vergata, Italy.
    Mair, A.
    Scottish Govt Health Department, Scotland.
    Molloy, W.
    University of Coll, Ireland.
    Monaco, A.
    AIFA Agenzia Italiana Farmaco, Italy.
    Monsonis-Paya, I.
    University of Valencia, Spain.
    Nizinska, A.
    University of Lower Silesia, Poland.
    Papadopoulos, H.
    National Centre Science Research, Greece.
    Pavlickova, A.
    European Innovat Partnership Act and Health Ageing, Scotland.
    Pecorelli, S.
    University of Brescia, Italy.
    Prados-Torres, A.
    IIS Aragon Aragon Health Science Institute IACS, Spain.
    Roller-Wirnsberger, R. E.
    Medical University of Graz, Austria.
    Somekh, D.
    European Health Futures Forum, England.
    Vera-Munoz, C.
    University of Politecn Madrid, Spain.
    Visser, F.
    Avisco, Netherlands.
    Farrell, J.
    Department Health Social Serv and Public Safety, North Ireland.
    Malva, J.
    University of Coimbra, Portugal; Ageing Coimbra EIP AHA, Portugal.
    Andersen Ranberg, K.
    Odense University Hospital, Denmark.
    Camuzat, T.
    European Innovat Partnership Act and Health Ageing Re, France; Regional Languedoc Roussillon Midi Pyrenees, France.
    Carriazo, A. M.
    Regional Minist Health Andalusia, Spain.
    Crooks, G.
    European Innovat Partnership Act and Health Ageing, Scotland.
    Gutter, Z.
    University Hospital Olomouc, Czech Republic.
    Iaccarino, G.
    University of Salerno, Italy.
    Manuel De Keenoy, E.
    Kronikgune, Spain.
    Moda, G.
    Regional Piemonte, Italy.
    Rodriguez-Manas, L.
    Getafe University Hospital, Spain.
    Vontetsianos, T.
    Sotiria Hospital, Greece.
    Abreu, C.
    Coimbra School Nursing, Portugal.
    Alonso, J.
    IMIM Institute Hospital Mar Invest Mediques, Spain.
    Alonso-Bouzon, C.
    Getafe University Hospital, Spain.
    Ankri, J.
    INSERM, France; University of Versailles St Quentin En Yvelines, France.
    Arredondo, M. T.
    University of Politecn Madrid, Spain.
    Avolio, F.
    Regional Puglia, Italy.
    Bedbrook, A.
    European Innovat Partnership Act and Health Ageing Re, France.
    Bialoszewski, A. Z.
    Medical University of Warsaw, Poland.
    Blain, H.
    European Innovat Partnership Act and Health Ageing Re, France; Montpellier University Hospital, France; University of Montpellier, France.
    Bourret, R.
    European Innovat Partnership Act and Health Ageing Re, France; Montpellier University Hospital, France.
    Cabrera-Umpierrez, M. F.
    University of Politecn Madrid, Spain; University of Politecn Madrid, Spain.
    Catala, A.
    Technical University of Catalonia, Spain.
    OCaoimh, R.
    University of Coll, Ireland.
    Cesari, M.
    Gerontopole Toulouse, France.
    Chavannes, N. H.
    Leiden University, Netherlands.
    Correia-Da-Sousa, J.
    University of Minho, Portugal.
    Dedeu, T.
    European Regional and Local Health Assoc, Belgium; University of Edinburgh, Scotland.
    Ferrando, M.
    University of Valencia, Spain.
    Ferri, M.
    University of Valencia, Spain.
    Fokkens, W. J.
    Academic Medical Centre, Netherlands.
    Garcia-Lizana, F.
    Institute Health Carlos III, Spain.
    Guerin, O.
    CHRU Nice, France.
    Hellings, P. W.
    Katholieke University of Leuven, Belgium.
    Haahtela, T.
    Helsinki University Hospital, Finland.
    Illario, M.
    Federico II University Hospital Naples, Italy.
    Inzerilli, M. C.
    Community St Egidio Long Live Elderly Program, Italy.
    Lodrup Carlsen, K. C.
    Oslo University Hospital, Norway; University of Oslo, Norway; Oslo University Hospital, Norway; University of Oslo, Norway.
    Kardas, P.
    Medical University of Lodz, Poland.
    Keil, T.
    Charite, Germany; University of Wurzburg, Germany.
    Maggio, M.
    University of Parma, Italy.
    Mendez-Zorrilla, A.
    University of Deusto, Spain.
    Menditto, E.
    University of Naples Federico II, Italy.
    Mercier, J.
    European Innovat Partnership Act and Health Ageing Re, France; University of Montpellier, France.
    Michel, J. P.
    European Union Geriatr Medical Soc, Switzerland; European Geriatr Med, Switzerland.
    Murray, R.
    NHS Scotland, Scotland.
    Nogues, M.
    European Innovat Partnership Act and Health Ageing Re, France; Caisse Assurance Retraite and Sante Travail Langued, France.
    OByrne-Maguire, I.
    AFFINITY, Ireland.
    Pappa, D.
    National Centre Science Research, Greece.
    Parent, A. S.
    AGE Platform Europe, Belgium.
    Pastorino, M.
    University of Politecn Madrid, Spain.
    Robalo-Cordeiro, C.
    Coimbra University Hospital, Portugal.
    Samolinski, B.
    Medical University of Warsaw, Poland.
    Siciliano, P.
    CNR, Italy; INNOVAAL, Italy.
    Teixeira, A. M.
    University of Coimbra, Portugal.
    Tsartara, S. I.
    South East Europe Healthcare Integrated Care and Sr, Greece.
    Valiulis, A.
    Vilnius University, Lithuania; European Academic Paediat EAP UEMS SP, Belgium; European Academic Paediat, Belgium.
    Vandenplas, O.
    Catholic University of Louvain, Belgium.
    Vasankari, T.
    Finnish Lung Assoc, Finland.
    Vellas, B.
    Gerontopole Toulouse, France.
    Vollenbroek-Hutten, M.
    Telemed Grp, Netherlands; University of Twente, Netherlands.
    Wickman, M.
    Soder Sjukhuset, Sweden; Karolinska Institute, Sweden.
    Yorgancioglu, A.
    A Celal Bayar University, Turkey; GARD Execut Comm, Turkey.
    Zuberbier, T.
    Charite, Germany; Global Allergy and Asthma European Network, Germany.
    Barbagallo, M.
    University of Palermo, Italy.
    Canonica, G. W.
    University of Genoa, Italy.
    Klimek, L.
    KLIMEK, Germany.
    Maggi, S.
    CNR Aging Branch, Italy.
    Aberer, W.
    Medical University of Graz, Austria.
    Akdis, C.
    University of Zurich, Switzerland.
    Adcock, I. M.
    Imperial Coll London, England; Royal Brompton and Harefield NHS Trust, England.
    Agache, I.
    Transylvania University of Brasov, Romania.
    Albera, C.
    University of Turin, Italy.
    Alonso-Trujillo, F.
    Andalusian Agency Social Serv and Dependency, Spain.
    Angel Guarcia, M.
    University of Valencia, Spain.
    Annesi-Maesano, I.
    INSERM, France; UPMC, France.
    Apostolo, J.
    Coimbra School Nursing, Portugal.
    Arshad, S. H.
    David Hide Asthma and Allergy Research Centre, England.
    Attalin, V.
    Aviitam, France.
    Avignon, A.
    Montpellier University Hospital, France.
    Bachert, C.
    Ghent University Hospital, Belgium.
    Baroni, I.
    Telbios, Italy.
    Bel, E.
    University of Amsterdam, Netherlands.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Bescos, C.
    Phillips Research Institute, Netherlands.
    Blasi, F.
    University of Milan, Italy.
    Barbara, C.
    Portuguese National Programme Resp Disease, Portugal.
    Bergmann, K. C.
    Charite, Germany; Global Allergy and Asthma European Network, Germany.
    Bernard, P. L.
    University of Montpellier, France.
    Bonini, S.
    University of Naples 2, Italy; Italian National Research Council, Italy.
    Bousquet, P. J.
    INSERM, France; UPMC, France.
    Branchini, B.
    University of Valencia, Spain.
    Brightling, C. E.
    University Hospital Leicester NHS Trust, England; University of Leicester, England.
    Bruguiere, V.
    Caisse Assurance Retraite and Sante Travail Langued, France.
    Bunu, C.
    University of Medical and Farm Timisoara, Romania.
    Bush, A.
    Bush A Imperial Coll, England; Royal Brompton Hospital, England.
    Caimmi, D. P.
    Montpellier University Hospital, France.
    Calderon, M. A.
    University of London Imperial Coll Science Technology and Med, England.
    Canovas, G.
    Maire, France.
    Cardona, V.
    Hospital Valle De Hebron, Spain.
    Carlsen, K. H.
    Oslo University Hospital, Norway; University of Oslo, Norway; Oslo University Hospital, Norway; University of Oslo, Norway.
    Cesario, A.
    IRCCS Azienda Osped Santa Maria Nuova, Italy.
    Chkhartishvili, E.
    Grigol Robakidze University, Rep of Georgia.
    Chiron, R.
    Montpellier University Hospital, France.
    Chivato, T.
    University of CEU San Pablo, Spain.
    Chung, K. F.
    University of London Imperial Coll Science Technology and Med, England.
    DAngelantonio, M.
    Health Informat Management SA, Belgium.
    De Carlo, G.
    EFA European Federat Allergy and Airways Disease Patien, Belgium.
    Cholley, D.
    Direct Regional Serv Med, France.
    Chorin, F.
    CIU Sante, France.
    Combe, B.
    University Hospital, France.
    Compas, B.
    Conseil Dep Herault, France.
    Costa, D. J.
    European Innovat Partnership Act and Health Ageing Re, France.
    Costa, E.
    University of Porto, Portugal; University of Porto, Portugal.
    Coste, O.
    Direct Regional Jeunesse Sports and Cohes Sociale, France.
    Coupet, A. -L.
    Caisse Assurance Retraite and Sante Travail Langued, France.
    Crepaldi, G.
    CNR, Italy.
    Custovic, A.
    University of London Imperial Coll Science Technology and Med, England.
    Dahl, R.
    Odense University Hospital, Denmark.
    Dahlen, S. E.
    Karolinska Institute, Sweden.
    Demoly, P.
    INSERM, France; UPMC, France; Montpellier University Hospital, France.
    Devillier, P.
    Suresnes University of Versailles St Quentin, France.
    Didier, A.
    Rangueil Larrey Hospital, France.
    Dinh-Xuan, A. T.
    University of Paris 05, France.
    Djukanovic, R.
    University of Southampton, England; NIHR Southampton Resp Biomed Research Unit, England.
    Dokic, D.
    University of Clin Pulmol and Allergy, Macedonia.
    Du Toit, G.
    Kings Coll London, England.
    Dubakiene, R.
    Vilnius University, Lithuania.
    Dupeyron, A.
    University of Montpellier, France; University of Nimes Hospital, France.
    Emuzyte, R.
    Vilnius University, Lithuania.
    Fiocchi, A.
    Bambino Gesu Childrens Research Hospital, Italy.
    Wagner, A.
    Global Allergy and Asthma Platform GAAPP, Austria.
    Fletcher, M.
    Educ Heatlh, England.
    Fonseca, J.
    Institute CUF Porto Hospital CUF Porto, Portugal; University of Porto, Portugal.
    Fougere, B.
    Gerontopole Toulouse, France.
    Gamkrelidze, A.
    National Centre Disease Control and Public Health Georgia, Rep of Georgia.
    Garces, G.
    University of Valencia, Spain.
    Garcia-Aymeric, J.
    ISGLoBAL, Spain.
    Garcia-Zapirain, B.
    University of Deusto, Spain.
    Gemicioglu, B.
    Istanbul University, Turkey.
    Gouder, C.
    Resident Medical Specialist Medical Mater Dei Hospital, Malta.
    Hellquist-Dahl, B.
    Odense University Hospital, Denmark.
    Hermosilla-Gimeno, I.
    Institute Salud Carlos III, Spain.
    Heve, D.
    Agence Regional Sante, France.
    Holland, C.
    Aston University, England.
    Humbert, M.
    University of Paris 11, France.
    Hyland, M.
    University of Plymouth, England.
    Johnston, S. L.
    University of London Imperial Coll Science Technology and Med, England; MRC and Asthma UK Centre Allerg Mech Asthma, England.
    Just, J.
    University of Paris 06, France.
    Jutel, M.
    Wroclaw Medical University, Poland.
    Kaidashev, I. P.
    Ukrainina Medical Stomatol Acad, Ukraine.
    Khaitov, M.
    National Research Centre, Russia.
    Kalayci, O.
    Hacettepe University, Turkey.
    Kalyoncu, A. F.
    Hacettepe University, Turkey.
    Keijser, W.
    University of Twente, Netherlands; Health Informat Management Spain SL, Spain.
    Kerstjens, H.
    University of Groningen, Netherlands.
    Knezovic, J.
    University of Zagreb, Croatia.
    Kowalski, M.
    Medical University of Lodz, Poland; HARC, Poland.
    Koppelman, G. H.
    University of Groningen, Netherlands.
    Kotska, T.
    Medical University of Lodz, Poland.
    Kovac, M.
    University of Zagreb, Croatia.
    Kull, I.
    Soder Sjukhuset, Sweden; Karolinska Institute, Sweden.
    Kuna, P.
    Barlicki University Hospital, Poland.
    Kvedariene, V.
    Vilnius University, Lithuania.
    Lepore, V.
    AReS Puglia, Italy.
    Macnee, W.
    University of Edinburgh, Scotland.
    Maggio, M.
    University of Parma, Italy.
    Magnan, A.
    University of Nantes, France; Institute Thorax, France.
    Majer, I.
    University of Bratislava, Slovakia.
    Manning, P.
    Bon Secours Hospital, Ireland.
    Marcucci, M.
    University of Milan, Italy; University of Milan, Italy.
    Marti, T.
    Generalitat Catalunya, Spain.
    Masoli, M.
    University of Plymouth, England.
    Melen, E.
    Stockholm County Council, Sweden.
    Miculinic, N.
    Croatian Pulm Soc, Croatia.
    Mihaltan, F.
    National Institute Pneumol M Nasta, Romania.
    Milenkovic, B.
    University of Belgrade, Serbia.
    Millot-Keurinck, J.
    Caisse Assurance Retraite and Sante Travail Langued, France.
    Mlinaric, H.
    University of Zagreb, Croatia.
    Momas, I.
    Paris Descartes University, France; Paris Municipal Department Social Act Childhood and Heatlh, France.
    Montefort, S.
    University of Malta, Malta.
    Morais-Almeida, M.
    Hospital CUF Descobertas, Portugal; Soc Portuguesa Alergol and Imunol Clin, Portugal.
    Moreno-Casbas, T.
    Institute Health Carlos III, Spain.
    Moesges, R.
    University of Cologne, Germany.
    Mullol, J.
    CIBERES, Spain; CIBERES, Spain.
    Nadif, R.
    INSERM, France; University of Versailles St Quentin En Yvelines, France.
    Nalin, M.
    Telbios, Italy.
    Navarro-Pardo, E.
    University of Valencia, Spain; University of Valencia, Spain.
    Nekam, K.
    Hospital Hospitaller Brothers Buda, Hungary.
    Ninot, G.
    University of Montpellier I, France.
    Paccard, D.
    Caisse Assurance Retraite and Sante Travail Langued, France.
    Pais, S.
    University of Algarve, Portugal.
    Palummeri, E.
    Gakkiera Hospital, Italy.
    Panzner, P.
    Charles University of Prague, Czech Republic; Charles University of Prague, Czech Republic.
    Papadopoulos, N. K.
    University of Manchester, England; University of Athens, Greece.
    Papanikolaou, C.
    Laikon Gen Hospital Athens, Greece.
    Passalacqua, G.
    University of Genoa, Italy.
    Pastor, E.
    LETAPE, France; Conseil Regional Ordre Masseurs Kinesitherapeutes, France.
    Perrot, M.
    Regime Social Independants, France.
    Plavec, D.
    University of JJ Strossmayer, Croatia.
    Popov, T. A.
    Alexanders University Hospital, Bulgaria.
    Postma, D. S.
    University of Groningen, Netherlands.
    Price, D.
    Optimum Patient Care, England; University of Aberdeen, Scotland.
    Raffort, N.
    Soc Public Locale Exploitat Balaruc Les Bains, France.
    Reuzeau, J. C.
    Caisse Assurance Retraite and Sante Travail Langued, France.
    Robine, J. M.
    INSERM, France; INSERM, France; Ecole Prat Hautes Etud, France.
    Rodenas, F.
    University of Valencia, Spain.
    Robusto, F.
    AReS Puglia, Italy.
    Roche, N.
    Hop University of Paris, India.
    Romano, A.
    Complesso Integrato Columbus, Italy.
    Romano, V.
    Piedmonte Reference Site, Italy.
    Rosado-Pinto, J.
    Serv Imunoalergol Hospital Luz Lisboa, Portugal.
    Roubille, F.
    European Innovat Partnership Act and Health Ageing Re, France; Montpellier University Hospital, France.
    Ruiz, F.
    University of Valencia, Spain.
    Ryan, D.
    Woodbrook Medical Centre, England; University of Edinburgh, Scotland.
    Salcedo, T.
    University of Politecn Valencia, Spain.
    Schmid-Grendelmeier, P.
    University of Zurich Hospital, Switzerland.
    Schulz, H.
    Helmholtz Zentrum Munchen, Germany.
    Schunemann, H. J.
    University of Freiburg, Germany.
    Serrano, E.
    CHU Rangueil Larrey, France.
    Sheikh, A.
    University of Edinburgh, Scotland.
    Shields, M.
    Queens University of Belfast, North Ireland; Royal Belfast Hospital Sick Children, North Ireland.
    Siafakas, N.
    University Hospital Heraklion, Greece.
    Scichilone, N.
    University of Palermo, Italy.
    Siciliano, P.
    CNR, Italy; INNOVAAL, Italy.
    Skrindo, I.
    Akershun University Hospital, Norway.
    Smit, H. A.
    University of Utrecht, Netherlands.
    Sourdet, S.
    Gerontopole Toulouse, France.
    Sousa-Costa, E.
    University of Porto, Portugal.
    Spranger, O.
    Global Allergy and Asthma Platform GAAPP, Austria.
    Sooronbaev, T.
    Euro Asian Resp Soc, Kyrgyzstan.
    Sruk, V.
    University of Zagreb, Croatia.
    Sterk, P. J.
    University of Amsterdam, Netherlands.
    Todo-Bom, A.
    University of Coimbra, Portugal.
    Touchon, J.
    University Hospital Montpellier, France.
    Tramontano, D.
    University of Naples Federico II, Italy; GENS Fdn, Italy.
    Triggiani, M.
    University of Salerno, Italy.
    Tsartara, S. I.
    South East Europe Healthcare Integrated Care and Sr, Greece.
    Valero, A. L.
    IDIBAPS, Spain.
    Valovirta, E.
    University of Turku, Finland.
    Van Ganse, E.
    University of Lyon 1, France.
    Van Hage, M.
    Karolinska Institute and University Hospital, Sweden.
    Van den Berge, M.
    University of Groningen, Netherlands.
    Vandenplas, O.
    Catholic University of Louvain, Belgium.
    Ventura, M. T.
    University of Bari, Italy.
    Vergara, I.
    VERGARA Itziar Kronikgune, Spain.
    Vezzani, G.
    Research Hospital, Italy; Regional Agency Health and Social Care, Italy.
    Vidal, D.
    University of Valencia, Spain.
    Viegi, G.
    CNR, Italy.
    Wagemann, M.
    University of Klinikum Dusseldorf, Germany.
    Whalley, B.
    University of Plymouth, England.
    Wickman, M.
    Soder Sjukhuset, Sweden; Karolinska Institute, Sweden.
    Wilson, N.
    North England EU Health Partnership, Australia.
    Yiallouros, P. K.
    Cyprus University of Technology, Cyprus; Hospital Archbishop Makarios III, Cyprus.
    Zagar, M.
    University of Zagreb, Croatia.
    Zaidi, A.
    University of Southampton, England.
    Zidarn, M.
    University of Clin Resp and Allerg Disease, Slovenia.
    Hoogerwerf, E. J.
    Funka, Sweden.
    Usero, J.
    Funka, Sweden.
    Zuffada, R.
    Funka, Sweden.
    Senn, A.
    European Commiss, Belgium.
    De Oliveira-Alves, B.
    European Commiss, Belgium.
    BUILDING BRIDGES FOR INNOVATION IN AGEING: SYNERGIES BETWEEN ACTION GROUPS OF THE EIP ON AHA2017Ingår i: The Journal of Nutrition, Health & Aging, ISSN 1279-7707, E-ISSN 1760-4788, Vol. 21, nr 1, s. 92-104Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).

  • 5.
    Wang, Hui
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. University of Texas MD Anderson Cancer Centre, TX 77030 USA.
    Nestor, Colm
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    GAB2 regulates type 2 T helper cell differentiation in humans2017Ingår i: Cytokine, ISSN 1043-4666, E-ISSN 1096-0023, Vol. 96, s. 234-237Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Th2 cell differentiation involves complex changes in expression of multiple genes, many of which have poorly characterized roles. In a gene expression microarray analysis of human primary CD4(+) effector T subsets, we identified that an adaptor protein, GAB2, was preferentially expressed in human Th2 cells. The role of GAB2 in human Th2 cells is unknown. Through analysis of primary and in vitro differentiated human T effector subsets, we confirmed that human Th2 cells preferentially expressed GAB2. Further analysis of public gene expression microarray data of STAT6-knockdowned Th2 cells indicated that GAB2 expression was regulated by IL-4 and STAT6. Both siRNA knockdown and ectopic expression of GAB2 in activated T cells showed that GAB2 positively regulated IL-4 and IL-13 expression in human Th2 cells. We hence identified the adaptor protein, GAB2, as an important novel regulator of the human Th2 immune response.

  • 6.
    Magnusson, Rasmus
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Mariotti, Guido
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Köpsén, Mattias
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
    Lövfors, William
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten.
    Gawel, Danuta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Jornsten, Rebecka
    University of Gothenburg, Sweden.
    Linde, Joerg
    Hans Knoell Institute, Germany; Hans Knoell Institute, Germany.
    Nordling, Torbjorn
    National Cheng Kung University, Taiwan; Science Life Lab, Sweden.
    Nyman, Elin
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
    Schulze, Sylvie
    Hans Knoell Institute, Germany.
    Nestor, Colm
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten.
    Zhang, Hanmin
    Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
    Cedersund, Gunnar
    Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Tjärnberg, Andreas
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Gustafsson, Mika
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    LASSIM-A network inference toolbox for genome-wide mechanistic modeling2017Ingår i: PloS Computational Biology, ISSN 1553-734X, E-ISSN 1553-7358, Vol. 13, nr 6, artikel-id e1005608Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Recent technological advancements have made time-resolved, quantitative, multi-omics data available for many model systems, which could be integrated for systems pharmacokinetic use. Here, we present large-scale simulation modeling (LASSIM), which is a novel mathematical tool for performing large-scale inference using mechanistically defined ordinary differential equations (ODE) for gene regulatory networks (GRNs). LASSIM integrates structural knowledge about regulatory interactions and non-linear equations with multiple steady state and dynamic response expression datasets. The rationale behind LASSIM is that biological GRNs can be simplified using a limited subset of core genes that are assumed to regulate all other gene transcription events in the network. The LASSIM method is implemented as a general-purpose toolbox using the PyGMO Python package to make the most of multicore computers and high performance clusters, and is available at https://gitlab.com/Gustafsson-lab/lassim. As a method, LASSIM works in two steps, where it first infers a non-linear ODE system of the pre-specified core gene expression. Second, LASSIM in parallel optimizes the parameters that model the regulation of peripheral genes by core system genes. We showed the usefulness of this method by applying LASSIM to infer a large-scale non-linear model of naive Th2 cell differentiation, made possible by integrating Th2 specific bindings, time-series together with six public and six novel siRNA-mediated knock-down experiments. ChIP-seq showed significant overlap for all tested transcription factors. Next, we performed novel time-series measurements of total T-cells during differentiation towards Th2 and verified that our LASSIM model could monitor those data significantly better than comparable models that used the same Th2 bindings. In summary, the LASSIM toolbox opens the door to a new type of model-based data analysis that combines the strengths of reliable mechanistic models with truly systems-level data. We demonstrate the power of this approach by inferring a mechanistically motivated, genome-wide model of the Th2 transcription regulatory system, which plays an important role in several immune related diseases.

  • 7.
    Zhang, Ling
    et al.
    Nanjing University, Peoples R China.
    Zhang, Hui
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Nanjing University, Peoples R China.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Nanjing University, Peoples R China.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Han, Xiaodong
    Nanjing University, Peoples R China.
    Li, Dongmei
    Nanjing University, Peoples R China.
    Roles of piRNAs in microcystin-leucine-arginine (MC-LR) induced reproductive toxicity in testis on male offspring2017Ingår i: Food and Chemical Toxicology, ISSN 0278-6915, E-ISSN 1873-6351, Vol. 105, s. 177-185Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    In the present study, we evaluated the toxic effects on the testis of the male offspring of MC-LR exposure during fetal and lactational periods. Pregnant females were distributed into two experimental groups: control group and MC-LR group which were exposed to 0 and 10 mu g/L of MC-LR, respectively, through drinking water separately during fetal and lactational periods. At the age of 30 days after birth, the male offspring were euthanized. The body weight, testis index, and histomorphology change were observed and the global changes of piwi-interacting RNA (piRNA) expression were evaluated. The results revealed that MC-LR was found in the testis of male offspring, body weight and testis index decreased significantly, and testicular tissue structure was damaged in the MC-LR group. In addition, the exposure to MCLR resulted in an altered piRNA expression profile and an increase of the cell apoptosis and a decrease of the cell proliferation in the testis of the male offspring. It was reasonable to speculate that the toxic effects on reproductive system of the male offspring in MC-LR group might be mediated by piRNAs through the regulation of the target genes. As far as we are aware, this is the first report showing that MC-LR could play a role in disorder of proliferative and cell apoptosis in the testis of the male offspring by the maternal transmission effect of toxicity. (C) 2017 Elsevier Ltd. All rights reserved.

  • 8.
    Shalek, Alex K.
    et al.
    MIT, MA USA; Broad Institute MIT and Harvard, MA 02142 USA; Ragon Institute Massachusetts Gen Hospital MIT and Harvard, MA 02139 USA.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Single-cell analyses to tailor treatments2017Ingår i: Science Translational Medicine, ISSN 1946-6234, E-ISSN 1946-6242, Vol. 9, nr 408, artikel-id eaan4730Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    Single-cell RNA-seq could play a key role in personalized medicine by facilitating characterization of cells, pathways, and genes associated with human diseases such as cancer.

  • 9.
    Nestor, Colm
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Lentini, Antonio
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Hägg Nilsson, Cathrine
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Gawel, Danuta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Gustafsson, Mika
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Mattson, Lina
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Wang, Hui
    MD Anderson Cancer Centre, TX 77030 USA.
    Rundquist, Olof
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Meehan, Richard R.
    University of Edinburgh, Scotland.
    Klocke, Bernward
    Genomatix Software GmbH, Germany.
    Seifert, Martin
    Genomatix Software GmbH, Germany.
    Hauck, Stefanie M.
    German Research Centre Environm Health GmbH, Germany.
    Laumen, Helmut
    Technical University of Munich, Germany; Technical University of Munich, Germany; Helmholtz Zentrum Munchen, Germany; Technical University of Munich, Germany; Technical University of Munich, Germany.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells2016Ingår i: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 16, nr 2, s. 559-570Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    5-methylcytosine (5mC) is converted to 5-hydroxymethylcytosine (5hmC) by the TET family of enzymes as part of a recently discovered active DNA de-methylation pathway. 5hmC plays important roles in regulation of gene expression and differentiation and has been implicated in T cell malignancies and autoimmunity. Here, we report early and widespread 5mC/5hmC remodeling during human CD4(+) T cell differentiation ex vivo at genes and cell-specific enhancers with known T cell function. We observe similar DNA de-methylation in CD4(+) memory T cells in vivo, indicating that early remodeling events persist long term in differentiated cells. Underscoring their important function, 5hmC loci were highly enriched for genetic variants associated with T cell diseases and T-cell-specific chromosomal interactions. Extensive functional validation of 22 risk variants revealed potentially pathogenic mechanisms in diabetes and multiple sclerosis. Our results support 5hmC-mediated DNA de-methylation as a key component of CD4(+) T cell biology in humans, with important implications for gene regulation and lineage commitment.

  • 10.
    Bousquet, J.
    et al.
    Montpellier University Hospital, France; European Innovat Partnership Act and Health Ageing Re, France; INSERM, France; CHRU Arnaud Villeneuve, France.
    Hellings, P. W.
    Katholieke University of Leuven, Belgium.
    Agache, I.
    Transylvania University of Brasov, Romania.
    Bedbrook, A.
    European Innovat Partnership Act and Health Ageing Re, France.
    Bachert, C.
    Ghent University Hospital, Belgium.
    Bergmann, K. C.
    Charite, Germany; Global Allergy and Asthma European Network, Germany.
    Bewick, M.
    iQ4U Consultants Ltd, England.
    Bindslev-Jensen, C.
    Odense University Hospital, Denmark.
    Bosnic-Anticevitch, S.
    Odense University Hospital, Denmark.
    Bucca, C.
    University of Sydney and Sydney Local Health Dist, Australia.
    Caimmi, D. P.
    Hospital City Health and Science Torino, Italy.
    Camargos, P. A. M.
    Montpellier University Hospital, France.
    Canonica, G. W.
    University of Federal Minas Gerais, Brazil.
    Casale, T.
    Humanitas University, Italy.
    Chavannes, N. H.
    University of S Florida, FL USA.
    Cruz, A. A.
    Leiden University, Netherlands; University of Federal Bahia, Brazil.
    De Carlo, G.
    GARD Execut Comm, Brazil.
    Dahl, R.
    Leiden University, Netherlands.
    Demoly, P.
    Hospital City Health and Science Torino, Italy; EFA European Federat Allergy and Airways Disease Patien, Belgium; INSERM, France.
    Devillier, P.
    University of Paris 06, France.
    Fonseca, J.
    Suresnes University of Versailles, France; Institute CUF Porto, Portugal.
    Fokkens, W. J.
    Hospital CUF Porto, Portugal.
    Guldemond, N. A.
    University of Porto, Portugal.
    Haahtela, T.
    Academic Medical Centre, Netherlands.
    Illario, M.
    Erasmus University, Netherlands.
    Just, J.
    Helsinki University Hospital, Finland.
    Keil, T.
    University of Naples Federico II, Italy; University of Paris 06, France.
    Klimek, L.
    Charite, Germany.
    Kuna, P.
    University of Wurzburg, Germany.
    Larenas-Linnemann, D.
    Centre Rhinol and Allergol, Germany.
    Morais-Almeida, M.
    Medical University of Lodz, Poland.
    Mullol, J.
    University of Barcelona, Spain.
    Murray, R.
    University of Chicago, IL 60637 USA.
    Naclerio, R.
    University of Chicago, IL 60637 USA.
    OHehir, R. E.
    Monash University, Australia; Monash University, Australia.
    Papadopoulos, N. G.
    Monash University, Australia; University of Manchester, England.
    Pawankar, R.
    University of Athens, Greece.
    Potter, P.
    Nippon Medical Sch, Japan.
    Ryan, D.
    University of Cape Town, South Africa; Woodbrook Medical Centre, England.
    Samolinski, B.
    University of Edinburgh, Scotland.
    Schunemann, H. J.
    Medical University of Warsaw, Poland.
    Sheikh, A.
    McMaster University, Canada.
    Simons, F. E. R.
    University of Edinburgh, Scotland.
    Stellato, C.
    University of Manitoba, Canada.
    Todo-Bom, A.
    University of Salerno, Italy.
    Tomazic, P. V.
    University of Coimbra, Portugal.
    Valiulis, A.
    Medical University of Graz, Austria; Vilnius University, Lithuania; Vilnius University, Lithuania.
    Valovirta, E.
    European Academic Paediat EAP UEMS SP, Belgium; University of Turku, Finland.
    Ventura, M. T.
    Terveystalo, Finland.
    Wickman, M.
    University of Bari, Italy; Soder Sjukhuset, Sweden.
    Young, I.
    Karolinska Institute, Sweden.
    Yorgancioglu, A.
    Queens University, North Ireland.
    Zuberbier, T.
    Charite, Germany; Global Allergy and Asthma European Network, Germany.
    Aberer, W.
    Celal Bayar University, Turkey.
    Akdis, C. A.
    Medical University of Graz, Austria.
    Akdis, M.
    Medical University of Graz, Austria.
    Annesi-Maesano, I.
    EFA European Federat Allergy and Airways Disease Patien, Belgium; INSERM, France.
    Ankri, J.
    INSERM, France.
    Ansotegui, I. J.
    University of Zurich, Switzerland.
    Anto, J. M.
    Hospital Quiron Bizkaia, Spain; Barcelona Institute Global Health ISGlobal, Spain; IMIM Hospital Mar Research Institute, Spain; CIBER Epidemiol and Salud Public CIBERESP, Spain.
    Arnavielhe, S.
    University of Pompeu Fabra, Spain.
    Asarnoj, A.
    University of Edinburgh, Scotland; Kyomed, France; Karolinska Institute, Sweden.
    Arshad, H.
    Karolinska University Hospital, Sweden.
    Avolio, F.
    David Hide Asthma and Allergy Research Centre, England.
    Baiardini, I.
    University of Federal Minas Gerais, Brazil.
    Barbara, C.
    Regional Puglia, Italy.
    Barbagallo, M.
    Portuguese National Programme Resp Disease PNDR, Portugal.
    Bateman, E. D.
    University of Palermo, Italy.
    Beghe, B.
    University of Cape Town, South Africa.
    Bel, E. H.
    University of Modena and Reggio Emilia, Italy.
    Bennoor, K. S.
    University of Amsterdam, Netherlands.
    Benson, Mikael
    Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Bialoszewski, A. Z.
    University of Edinburgh, Scotland.
    Bieber, T.
    Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany.
    Bjermer, L.
    University of Bonn, Germany.
    Blain, H.
    Lund University Hospital, Sweden; Montpellier University Hospital, France.
    Blasi, F.
    University of Montpellier, France.
    Boner, A. L.
    University of Milan, Italy.
    Bonini, M.
    Sapienza University, Rome, Italy.
    Bonini, S.
    University of Verona Hospital, Italy; University of Roma La Sapienza, Italy.
    Bosse, I.
    University of Naples 2, Italy.
    Bouchard, J.
    Italian National Research Council, Italy.
    Boulet, L. P.
    University of Laval, Canada.
    Bourret, R.
    Montpellier University Hospital, France.
    Bousquet, P. J.
    EFA European Federat Allergy and Airways Disease Patien, Belgium.
    Braido, F.
    University of Federal Minas Gerais, Brazil.
    Briggs, A. H.
    University of Glasgow, Scotland.
    Brightling, C. E.
    University Hospital Leicester NHS Trust, England; University of Leicester, England.
    Brozek, J.
    Medical University of Warsaw, Poland.
    Buhl, R.
    Johannes Gutenberg University of Mainz, Germany.
    Bunu, C.
    University of Medical and Farm Timisoara, Romania.
    Burte, E.
    INSERM, France.
    Bush, A.
    University of Medical and Farm Timisoara, Romania; University of London Imperial Coll Science Technology and Med, England.
    Caballero-Fonseca, F.
    Centre Medical Docente Trinidad, Venezuela.
    Calderon, M. A.
    University of Medical and Farm Timisoara, Romania; University of London Imperial Coll Science Technology and Med, England; University of London Imperial Coll Science Technology and Med, England.
    Camuzat, T.
    Regional Languedoc Roussillon, France.
    Cardona, V.
    Hospital Valle De Hebron, Spain.
    Carreiro-Martins, P.
    CEDOC, Portugal; Centre Hospital Lisboa Cent, Portugal.
    Carriazo, A. M.
    Regional Minist Health Andalusia, Spain.
    Carlsen, K. H.
    Oslo University Hospital, Norway; University of Oslo, Norway; University of Oslo, Norway.
    Carr, W.
    Allergy and Asthma Associates Southern Calif, CA USA.
    Cepeda Sarabia, A. M.
    Metropolitan University, Colombia; SLaai Sociedad Latinoamer Allergia Asma and Immunol, Colombia.
    Cesari, M.
    Gerontopole Toulouse, France.
    Chatzi, L.
    University of Crete, Greece.
    Chiron, R.
    Hospital City Health and Science Torino, Italy.
    Chivato, T.
    University of CEU San Pablo, Spain.
    Chkhartishvili, E.
    Grigol Robakidze University, Rep of Georgia.
    Chuchalin, A. G.
    Pulmonolory Research Institute FMBA, Russia; GARD Execut Comm, Russia.
    Chung, K. F.
    University of London Imperial Coll Science Technology and Med, England.
    Ciprandi, G.
    IRCCS Azienda Osped University of San Martino, Italy.
    Correia de Sousa, J.
    University of Minho, Portugal.
    Cox, L.
    Nova Southeastern University, FL USA.
    Crooks, G.
    Scottish Centre Telehealth and Telecare, Scotland.
    Custovic, A.
    University of London Imperial Coll Science Technology and Med, England.
    Dahlen, S. E.
    Karolinska Institute, Sweden.
    Darsow, U.
    Technical University of Munich, Germany; Helmholtz Centre Munich, Germany.
    Dedeu, T.
    AQuAS, Spain; European Regional and Local Health Assoc, Belgium.
    Deleanu, D.
    Luliu Hatieganu University of Medical and Pharm, Romania.
    Denburg, J. A.
    McMaster University, Canada.
    De Vries, G.
    Peercode DV, Netherlands.
    Didier, A.
    Rangueil Larrey Hospital, France.
    Dinh-Xuan, A. T.
    University of Paris 05, France.
    Dokic, D.
    Ss Cyril and Methodius University, Macedonia.
    Douagui, H.
    Centre Hospital University of Beni Messous, Algeria.
    Dray, G.
    Ecole Mines, France.
    Dubakiene, R.
    Vilnius University, Lithuania.
    Durham, S. R.
    University of London Imperial Coll Science Technology and Med, England.
    Du Toit, G.
    Kings Coll London, England.
    Dykewicz, M. S.
    St Louis University, MO USA.
    Eklund, P.
    Umeå University, Sweden; Four Comp Oy, Finland.
    El-Gamal, Y.
    Ain Shams University, Egypt.
    Ellers, E.
    Odense University Hospital, Denmark.
    Emuzyte, R.
    Medical University of Graz, Austria; Vilnius University, Lithuania; Vilnius University, Lithuania.
    Farrell, J.
    Social Serv and Public Safety, North Ireland.
    Fink Wagner, A.
    Global Allergy and Asthma Platform, Austria.
    Fiocchi, A.
    Bambino Gesu Childrens Research Hospital Holy See, Italy.
    Fletcher, M.
    Educ Heatlh, England.
    Forastiere, F.
    Regional Health Serv Lazio Reg, Italy.
    Gaga, M.
    Athens Chest Hospital, Greece.
    Gamkrelidze, A.
    National Centre Disease Control and Public Health Georgia, Rep of Georgia.
    Gemicioglu, B.
    Istanbul University, Turkey.
    Gereda, J. E.
    Clin Ricardo Palma, Peru.
    Gerth van Wick, R.
    Erasmus MC, Netherlands.
    Gonzalez Diaz, S.
    University of Autonoma Nuevo Leon, Mexico.
    Grisle, I.
    Latvian Assoc Allergists, Latvia.
    Grouse, L.
    University of Washington, WA 98195 USA.
    Gutter, Z.
    University Hospital Olomouc, Czech Republic.
    Guzman, M. A.
    University of Chile, Chile.
    Hellquist-Dahl, B.
    Odense University Hospital, Denmark.
    Heinrich, J.
    German Research Centre Environm Heatlh, Germany.
    Horak, F.
    Vienna Challenge Chamber, Austria.
    Hourihane, J. O. B.
    University of Coll Cork, Ireland.
    Humbert, M.
    University of Paris 11, France; Hop Bicetre, France; INSERM, France.
    Hyland, M.
    University of Plymouth, England.
    Iaccarino, G.
    University of Salerno, Italy.
    Jares, E. J.
    Libra Fdn, Argentina.
    Jeandel, C.
    European Innovat Partnership Act and Health Ageing Re, France; University Hospital, Sweden.
    Johnston, S. L.
    University of London Imperial Coll Science Technology and Med, England; MRC and Asthma UK Centre Allerg Mech Asthma, England.
    Joos, G.
    Ghent University Hospital, Belgium.
    Jonquet, O.
    Montpellier University Hospital, France.
    Jung, K. S.
    Hallym University, South Korea.
    Jutel, M.
    Wroclaw Medical University, Poland.
    Kaidashev, I.
    Ukrainian Medical Stomatol Acad, Ukraine.
    Khaitov, M.
    Federal Medicobiol Agency, Russia.
    Kalayci, O.
    Hacettepe University, Turkey.
    Kalyoncu, A. F.
    Hacettepe University, Turkey.
    Kardas, P.
    Medical University of Lodz, Poland.
    Keith, P. K.
    McMaster University, Canada.
    Kerkhof, M.
    University of Groningen, Netherlands.
    Kerstjens, H. A. M.
    University of Groningen, Netherlands.
    Khaltaev, N.
    GARD, Switzerland.
    Kogevinas, M.
    Hospital Quiron Bizkaia, Spain; Barcelona Institute Global Health ISGlobal, Spain; IMIM Hospital Mar Research Institute, Spain; CIBER Epidemiol and Salud Public CIBERESP, Spain.
    Kolek, V.
    University Hospital Olomouc, Czech Republic.
    Koppelman, G. H.
    University of Groningen, Netherlands.
    Kowalski, M. L.
    Medical University of Lodz, Poland.
    Kuitunen, M.
    University of Helsinki, Finland.
    Kull, I.
    University of Bari, Italy; Soder Sjukhuset, Sweden.
    Kvedariene, V.
    Vilnius University, Lithuania.
    Lambrecht, B.
    University of Ghent, Belgium.
    Lau, S.
    Charite, Germany.
    Laune, D.
    University of Pompeu Fabra, Spain.
    Le, L. T. T.
    University of Medical and Pharm, Vietnam.
    Lieberman, P.
    University of Tennessee, TN USA.
    Lipworth, B.
    University of Dundee, Scotland.
    Li, J.
    Guangzhou Medical University, Peoples R China.
    Lodrup Carlsen, K. C.
    Oslo University Hospital, Norway; University of Oslo, Norway; University of Oslo, Norway.
    Louis, R.
    CHU Sart Tilman, Belgium.
    Lupinek, C.
    Medical University of Vienna, Austria.
    MacNee, W.
    University of Edinburgh, Scotland.
    Magar, Y.
    Hop St Joseph, France.
    Magnan, A.
    University of Nantes, France; University of Nantes, France.
    Mahboub, B.
    Rashid Hospital, U Arab Emirates.
    Maier, D.
    Biomax Informat AG, Germany.
    Majer, I.
    University of Bratislava, Slovakia.
    Malva, J.
    University of Coimbra, Portugal; Ageing@Coimbra EIP AHA Reference Site, Portugal.
    Manning, P.
    Bon Secours Hospital, Ireland.
    De Manuel Keenoy, E.
    Kronikgune, Spain.
    Marshall, G. D.
    University of Mississippi, MS USA.
    Masjedi, M. R.
    Iranian Anti Tobacco Assoc, Iran.
    Mathieu-Dupas, E.
    University of Pompeu Fabra, Spain.
    Maurer, M.
    Charite, Germany.
    Mavale-Manuel, S.
    Maputo Central Hospital, Mozambique.
    Melen, E.
    University of Bari, Italy; Soder Sjukhuset, Sweden.
    Melo-Gomes, E.
    Regional Puglia, Italy.
    Meltzer, E. O.
    Allergy and Asthma Medical Grp and Research Centre, CA USA.
    Mercier, J.
    University of Montpellier, France.
    Merk, H.
    Rhein Westfal TH Aachen, Germany.
    Miculinic, N.
    Croatian Pulm Soc, Croatia.
    Mihaltan, F.
    National Institute Pneumol M Nasta, Romania.
    Milenkovic, B.
    University of Belgrade, Serbia; Serbian Assoc Asthma and COPD, Serbia.
    Millot-Keurinck, J.
    Caisse Assurance Retraite and Sante Travail Langued, France.
    Mohammad, Y.
    Tishreen University, Syria.
    Momas, I.
    Paris Descartes University, France; Paris Municipal Department Social Act Childhood and Heatlh, France.
    Mosges, R.
    University of Cologne, Germany.
    Muraro, A.
    Padua Gen University Hospital, Italy.
    Namazova-Baranova, L.
    Russian Academic Medical Science, Russia.
    Nadif, R.
    INSERM, France.
    Neffen, H.
    Hospital Ninos Orlando Alassia, Argentina.
    Nekam, K.
    Hospital Hospital Bros Buda, Hungary.
    Nieto, A.
    Hospital La Fe, Spain.
    Niggemann, B.
    Charite, Germany.
    Nogueira-Silva, L.
    Suresnes University of Versailles, France; University of Porto, Portugal; Institute CUF Porto, Portugal; Centre Hospital Sao Joao, Portugal.
    Nogues, M.
    European Innovat Partnership Act and Health Ageing Re, France; Caisse Assurance Retraite and Sante Travail Langued, France.
    Nyembue, T. D.
    University Hospital Kinshasa, DEM REP CONGO.
    Ohta, K.
    Tokyo National Hospital, Japan.
    Okamoto, Y.
    Chiba University Hospital, Japan.
    Okubo, K.
    Nippon Medical Sch, Japan.
    Olive-Elias, M.
    Montpellier University Hospital, France; University of Porto, Portugal; Academic Medical Centre, Netherlands.
    Ouedraogo, S.
    Centre Hospital University of Pediatr Charles Gaulle, Burkina Faso.
    Paggiaro, P.
    University Hospital Pisa, Italy.
    Pali-Schoell, I.
    Medical University, Austria.
    Palkonen, S.
    GARD Execut Comm, Brazil.
    Panzner, P.
    Charles University of Prague, Czech Republic.
    Papi, A.
    University of Ferrara, Italy.
    Park, H. S.
    Ajou University, South Korea.
    Passalacqua, G.
    University of Federal Minas Gerais, Brazil.
    Pedersen, S.
    University of Southern Denmark, Denmark.
    Pereira, A. M.
    Suresnes University of Versailles, France; University of Porto, Portugal; Institute CUF Porto, Portugal; CUF Porto Hospital and Institute, Portugal.
    Pfaar, O.
    Charite, Germany; Heidelberg University, Germany.
    Picard, R.
    Minist Econ Ind and Numer, France.
    Pigearias, B.
    Espace Francophone Pneumol, France.
    Pin, I.
    CHU Grenoble, France.
    Plavec, D.
    Childrens Hospital Srebrnjak, Croatia; University of JJ Strossmayer, Croatia.
    Pohl, W.
    Hietzing Hospital, Austria.
    Popov, T. A.
    Medical University of Sofia, Bulgaria.
    Portejoie, F.
    European Innovat Partnership Act and Health Ageing Re, France.
    Postma, D.
    University of Groningen, Netherlands.
    Poulsen, L. K.
    Copenhagen University Hospital Gentofte, Denmark.
    Price, D.
    University of Aberdeen, Scotland; Research Real Life, England.
    Rabe, K. F.
    German Centre Lung Research DZL, Germany; University of Kiel, Germany.
    Raciborski, F.
    University of Edinburgh, Scotland.
    Roberts, G.
    Southampton University Hospital, England.
    Robalo-Cordeiro, C.
    Coimbra University Hospital, Portugal.
    Rodenas, F.
    University of Valencia, Spain.
    Rodriguez-Manas, L.
    Getafe University Hospital, Spain.
    Rolland, C.
    Assoc Asthme and Allergie, France.
    Roman Rodriguez, M.
    Institute Invest Sanitaria Palma IdisPa, Spain.
    Romano, A.
    Complesso Integrato Columbus, Italy.
    Rosado-Pinto, J.
    Hospital Luz, Portugal.
    Rosario, N.
    University of Parana, Brazil.
    Rottem, M.
    Emek Medical Centre, Israel.
    Sanchez-Borges, M.
    Centre Medical Docente Trinidad and Clin El Avila, Venezuela.
    Sastre-Dominguez, J.
    Autononous University of Madrid, Spain.
    Scadding, G. K.
    UCL, England.
    Scichilone, N.
    University of Palermo, Italy.
    Schmid-Grendelmeier, P.
    University of Zurich Hospital, Switzerland.
    Serrano, E.
    CHU Rangueil Larrey, France.
    Shields, M.
    Queens University, North Ireland; Royal Belfast Hospital Sick Children, North Ireland.
    Siroux, V.
    University of Joseph Fourier, France.
    Sisul, J. C.
    Soc Paraguaya Alergia Asma and Inmunol, Paraguay.
    Skrindo, I.
    Oslo University Hospital, Norway; University of Oslo, Norway.
    Smit, H. A.
    University of Utrecht, Netherlands.
    Sole, D.
    University of Federal Sao Paulo, Brazil.
    Sooronbaev, T.
    Euro Asian Resp Soc, Kyrgyzstan.
    Spranger, O.
    Global Allergy and Asthma Platform, Austria.
    Stelmach, R.
    University of Sao Paulo, Brazil.
    Sterk, P. J.
    University of Amsterdam, Netherlands.
    Strandberg, T.
    European Union Geriatr Medical Soc EUGMS, Finland.
    Sunyer, J.
    Hospital Quiron Bizkaia, Spain; Barcelona Institute Global Health ISGlobal, Spain; IMIM Hospital Mar Research Institute, Spain; CIBER Epidemiol and Salud Public CIBERESP, Spain.
    Thijs, C.
    Maastricht University, Netherlands.
    Triggiani, M.
    University of Manitoba, Canada.
    Valenta, R.
    Medical University of Vienna, Austria.
    Valero, A.
    IDIBAPS, Spain.
    van Eerd, M.
    Peercode DV, Netherlands.
    van Ganse, E.
    PELyon, France; University of Claude Bernard Lyon, France.
    van Hague, M.
    Kyomed, France; Karolinska Institute, Sweden; University Hospital, Sweden.
    Vandenplas, O.
    Catholic University of Louvain, Belgium.
    Varona, L. L.
    Philippines Soc Allergy Asthma and Immunol, Philippines.
    Vellas, B.
    Gerontopole Toulouse, France.
    Vezzani, G.
    Research Hospital, Italy; Regional Agency Health and Social Care, Italy.
    Vazankari, T.
    Finnish Lung Assoc FILHA, Finland.
    Viegi, G.
    CNR Institute Clin Physiol, Italy; CNR, Italy.
    Vontetsianos, T.
    Sotiria Hospital, Greece.
    Wagenmann, M.
    University of Klinikum Dusseldorf, Germany.
    Walker, S.
    Asthma UK, England.
    Wang, D. Y.
    National University of Singapore, Singapore.
    Wahn, U.
    Charite, Germany.
    Werfel, T.
    Hannover Medical Sch, Germany.
    Whalley, B.
    University of Plymouth, England.
    Williams, D. M.
    University of N Carolina, NC USA.
    Williams, S.
    IPCRG, Scotland.
    Wilson, N.
    Northern Health Alliance, England.
    Wright, J.
    Bradford Royal Infirm, England.
    Yawn, B. P.
    Olmsted Medical Centre, MN USA.
    Yiallouros, P. K.
    University of Cyprus, Cyprus.
    Yusuf, O. M.
    Allergy and Asthma Institute, Pakistan.
    Zaidi, A.
    University of Southampton, England.
    Zar, H. J.
    University of Cape Town, South Africa; University of Cape Town, South Africa.
    Zernotti, M. E.
    University of Catolica Cordoba, Argentina.
    Zhang, L.
    Beijing TongRen Hospital, Peoples R China; Beijing Institute Otolaryngol, Peoples R China.
    Zhong, N.
    Guangzhou Medical University, Peoples R China.
    Zidarn, M.
    University of Clin Resp and Allerg Disease, Slovenia.
    ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle2016Ingår i: Clinical and Translational Allergy, ISSN 2045-7022, E-ISSN 2045-7022, Vol. 6, artikel-id 47Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.

  • 11.
    Serra-Musach, Jordi
    et al.
    Bellvitge Institute Biomed Research IDIBELL, Spain.
    Mateo, Francesca
    Bellvitge Institute Biomed Research IDIBELL, Spain.
    Capdevila-Busquets, Eva
    Barcelona Institute Science and Technology, Spain.
    Ruiz de Garibay, Gorka
    Bellvitge Institute Biomed Research IDIBELL, Spain.
    Zhang, Xiaohu
    NIH, MD 20850 USA.
    Guha, Raj
    NIH, MD 20850 USA.
    Thomas, Craig J.
    NIH, MD 20850 USA.
    Grueso, Judit
    VHIO, Spain.
    Villanueva, Alberto
    Bellvitge Institute Biomed Research IDIBELL, Spain.
    Jaeger, Samira
    Barcelona Institute Science and Technology, Spain.
    Heyn, Holger
    IDIBELL, Spain.
    Vizoso, Miguel
    IDIBELL, Spain.
    Perez, Hector
    IDIBELL, Spain.
    Cordero, Alex
    IDIBELL, Spain.
    Gonzalez-Suarez, Eva
    IDIBELL, Spain.
    Esteller, Manel
    IDIBELL, Spain; University of Barcelona, Spain; University of Barcelona, Spain; ICREA, Spain.
    Moreno-Bueno, Gema
    Autonomous University of Madrid, Spain; MD Anderson Int Fdn, Spain.
    Tjärnberg, Andreas
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Lazaro, Conxi
    IDIBELL, Spain.
    Serra, Violeta
    VHIO, Spain.
    Arribas, Joaquin
    ICREA, Spain; VHIO, Spain; Autonomous University of Barcelona, Spain.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Gustafsson, Mika
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Ferrer, Marc
    NIH, MD 20850 USA.
    Aloy, Patrick
    Barcelona Institute Science and Technology, Spain; ICREA, Spain.
    Angel Pujana, Miquel
    Bellvitge Institute Biomed Research IDIBELL, Spain.
    Cancer network activity associated with therapeutic response and synergism2016Ingår i: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 8, nr 88Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Cancer patients often show no or only modest benefit from a given therapy. This major problem in oncology is generally attributed to the lack of specific predictive biomarkers, yet a global measure of cancer cell activity may support a comprehensive mechanistic understanding of therapy efficacy. We reasoned that network analysis of omic data could help to achieve this goal. Methods: A measure of "cancer network activity" (CNA) was implemented based on a previously defined network feature of communicability. The network nodes and edges corresponded to human proteins and experimentally identified interactions, respectively. The edges were weighted proportionally to the expression of the genes encoding for the corresponding proteins and relative to the number of direct interactors. The gene expression data corresponded to the basal conditions of 595 human cancer cell lines. Therapeutic responses corresponded to the impairment of cell viability measured by the half maximal inhibitory concentration (IC50) of 130 drugs approved or under clinical development. Gene ontology, signaling pathway, and transcription factor-binding annotations were taken from public repositories. Predicted synergies were assessed by determining the viability of four breast cancer cell lines and by applying two different analytical methods. Results: The effects of drug classes were associated with CNAs formed by different cell lines. CNAs also differentiate target families and effector pathways. Proteins that occupy a central position in the network largely contribute to CNA. Known key cancer-associated biological processes, signaling pathways, and master regulators also contribute to CNA. Moreover, the major cancer drivers frequently mediate CNA and therapeutic differences. Cell-based assays centered on these differences and using uncorrelated drug effects reveals novel synergistic combinations for the treatment of breast cancer dependent on PI3K-mTOR signaling. Conclusions: Cancer therapeutic responses can be predicted on the basis of a systems-level analysis of molecular interactions and gene expression. Fundamental cancer processes, pathways, and drivers contribute to this feature, which can also be exploited to predict precise synergistic drug combinations.

  • 12.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Clinical implications of omics and systems medicine: focus on predictive and individualized treatment2016Ingår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 279, nr 3, s. 229-240Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Many patients with common diseases do not respond to treatment. This is a key challenge to modern health care, which causes both suffering and enormous costs. One important reason for the lack of treatment response is that common diseases are associated with altered interactions between thousands of genes, in combinations that differ between subgroups of patients who do or do not respond to a given treatment. Such subgroups, or even distinct disease entities, have been described recently in asthma, diabetes, autoimmune diseases and cancer. High-throughput techniques (omics) allow identification and characterization of such subgroups or entities. This may have important clinical implications, such as identification of diagnostic markers for individualized medicine, as well as new therapeutic targets for patients who do not respond to existing drugs. For example, whole-genome sequencing may be applied to more accurately guide treatment of neurodevelopmental diseases, or to identify drugs specifically targeting mutated genes in cancer. A study published in 2015 showed that 28% of hepatocellular carcinomas contained mutated genes that potentially could be targeted by drugs already approved by the US Food and Drug Administration. A translational study, which is described in detail, showed how combined omics, computational, functional and clinical studies could identify and validate a novel diagnostic and therapeutic candidate gene in allergy. Another important clinical implication is the identification of potential diagnostic markers and therapeutic targets for predictive and preventative medicine. By combining computational and experimental methods, early disease regulators may be identified and potentially used to predict and treat disease before it becomes symptomatic. Systems medicine is an emerging discipline, which may contribute to such developments through combining omics with computational, functional and clinical studies. The aims of this review are to provide a brief introduction to systems medicine and discuss how it may contribute to the clinical implementation of individualized treatment, using clinically relevant examples.

  • 13.
    Auffray, Charles
    et al.
    European Institute Syst Biol and Med, France; University of Lyon, France.
    Balling, Rudi
    University of Luxembourg, Luxembourg.
    Barroso, Ines
    Wellcome Trust Sanger Institute, England.
    Bencze, Laszlo
    Semmelweis University, Hungary.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Bergeron, Jay
    Pfizer Inc, MA 02139 USA.
    Bernal-Delgado, Enrique
    IACS IIS Aragon, Spain.
    Blomberg, Niklas
    ELIXIR, England.
    Bock, Christoph
    Austrian Academic Science, Austria; Austrian Academic Science, Austria; Max Planck Institute Informat, Germany.
    Conesa, Ana
    Principe Felipe Research Centre, Spain; University of Florida, FL 32610 USA.
    Del Signore, Susanna
    Bluecompan Ltd, England.
    Delogne, Christophe
    KPMG Luxembourg, Luxembourg.
    Devilee, Peter
    Leiden University, Netherlands.
    Di Meglio, Alberto
    European Org Nucl Research, Switzerland.
    Eijkemans, Marinus
    University of Medical Centre Utrecht, Netherlands.
    Flicek, Paul
    EMBL EBI, England.
    Graf, Norbert
    University of Saarland, Germany.
    Grimm, Vera
    Forschungszentrum Julich, Germany.
    Guchelaar, Henk-Jan
    Leiden University, Netherlands.
    Guo, Yi-Ke
    Imperial Coll London, England.
    Glynne Gut, Ivo
    BIST, Spain.
    Hanbury, Allan
    TU Wien, Austria.
    Hanif, Shahid
    Assoc British Pharmaceut Ind, England.
    Hilgers, Ralf-Dieter
    Rhein Westfal TH Aachen, Germany.
    Honrado, Angel
    SYNAPSE Research Management Partners, Spain.
    Rod Hose, D.
    University of Sheffield, England.
    Houwing-Duistermaat, Jeanine
    University of Leeds, England.
    Hubbard, Tim
    Kings Coll London, England; Genom England, England.
    Helen Janacek, Sophie
    EMBL EBI, England.
    Karanikas, Haralampos
    University of Athens, Greece.
    Kievits, Tim
    Vitromics Healthcare Holding BV, Netherlands.
    Kohler, Manfred
    Fraunhofer Institute Molecular Biol and Appl Ecol ScreeningPor, Germany.
    Kremer, Andreas
    ITTM SA, Luxembourg.
    Lanfear, Jerry
    Pfizer Ltd, England.
    Lengauer, Thomas
    Max Planck Institute Informat, Germany.
    Maes, Edith
    Deloitte Belgium, Belgium.
    Meert, Theo
    Janssen Pharmaceut NV, Belgium.
    Muller, Werner
    University of Manchester, England.
    Nickel, Dothe
    Institute Curie, France.
    Oledzki, Peter
    Linguamat Ltd, England.
    Pedersen, Bertrand
    PwC Luxembourg, Luxembourg.
    Petkovic, Milan
    Philips, Netherlands.
    Pliakos, Konstantinos
    KU Leuven Kulak, Belgium.
    Rattray, Magnus
    University of Manchester, England.
    Redon i Mas, Josep
    University of Valencia, Spain.
    Schneider, Reinhard
    University of Luxembourg, Luxembourg.
    Sengstag, Thierry
    SIB, Switzerland; University of Basel, Switzerland.
    Serra-Picamal, Xavier
    Agency Health Qual and Assessment Catalonia AQuAS, Spain.
    Spek, Wouter
    EuroBioForum Fdn, Netherlands.
    Vaas, Lea A. I.
    Fraunhofer Institute Molecular Biol and Appl Ecol ScreeningPor, Germany.
    van Batenburg, Okker
    EuroBioForum Fdn, Netherlands.
    Vandelaer, Marc
    Integrated BioBank Luxembourg, Luxembourg.
    Varnai, Peter
    Technopolis Grp, England.
    Villoslada, Pablo
    Hospital Clin Barcelona, Spain.
    Antonio Vizcaino, Juan
    EMBL EBI, England.
    Peter Mary Wubbe, John
    Epposi, Belgium.
    Zanetti, Gianluigi
    CRS4, Italy; BBMRI ERIC, Austria.
    Correction: Making sense of big data in health research: towards an EU action plan (vol 8, pg 71, 2016)2016Ingår i: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 8, artikel-id 118Artikel i tidskrift (Övrigt vetenskapligt)
    Abstract [en]

    n/a

  • 14.
    Hellberg, Sandra
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Eklund, Daniel
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Gawel, Danuta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Köpsén, Mattias
    Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Nestor, Colm
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Kockum, Ingrid
    Karolinska Institute, Department Clin Neurosci, Neuroimmunol Unit, S-17177 Linkoping, Sweden.
    Olsson, Tomas
    Karolinska Institute, Department Clin Neurosci, Neuroimmunol Unit, S-17177 Linkoping, Sweden.
    Skogh, Thomas
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Reumatologiska kliniken i Östergötland.
    Kastbom, Alf
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Reumatologiska kliniken i Östergötland.
    Sjöwall, Christopher
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Reumatologiska kliniken i Östergötland.
    Vrethem, Magnus
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Närsjukvården i centrala Östergötland, Neurologiska kliniken.
    Håkansson, Irene
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Jenmalm, Maria
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Gustafsson, Mika
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Dynamic Response Genes in CD4+T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis2016Ingår i: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 16, nr 11, s. 2928-2939Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS and has a varying disease course as well as variable response to treatment. Biomarkers may therefore aid personalized treatment. We tested whether in vitro activation of MS patient-derived CD4+ T cells could reveal potential biomarkers. The dynamic gene expression response to activation was dysregulated in patient-derived CD4+ T cells. By integrating our findings with genome-wide association studies, we constructed a highly connected MS gene module, disclosing cell activation and chemotaxis as central components. Changes in several module genes were associated with differences in protein levels, which were measurable in cerebrospinal fluid and were used to classify patients from control individuals. In addition, these measurements could predict disease activity after 2 years and distinguish low and high responders to treatment in two additional, independent cohorts. While further validation is needed in larger cohorts prior to clinical implementation, we have uncovered a set of potentially promising biomarkers.

  • 15.
    Auffray, Charles
    et al.
    European Institute Syst Biol and Med, France; University of Lyon, France.
    Balling, Rudi
    University of Luxembourg, Luxembourg.
    Barroso, Ines
    Wellcome Trust Sanger Institute, England.
    Bencze, Laszlo
    Semmelweis University, Hungary.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Bergeron, Jay
    Pfizer Inc, MA 02139 USA.
    Bernal-Delgado, Enrique
    IACS IIS Aragon, Spain.
    Blomberg, Niklas
    EL IXIR, England.
    Bock, Christoph
    Austrian Academic Science, Austria; Medical University of Vienna, Austria; Max Planck Institute Informat, Germany.
    Conesa, Ana
    Principe Felipe Research Centre, Spain; University of Florida, FL 32610 USA.
    Del Signore, Susanna
    Bluecompan Ltd, England.
    Delogne, Christophe
    KPMG Luxembourg, Luxembourg.
    Devilee, Peter
    Leiden University, Netherlands.
    Di Meglio, Alberto
    European Org Nucl Research CERN, Switzerland.
    Eijkemans, Marinus
    University of Utrecht, Netherlands.
    Flicek, Paul
    European Bioinformat Institute EMBL EBI, England.
    Graf, Norbert
    University of Saarland, Germany.
    Grimm, Vera
    Forschungszentrum Julich, Germany.
    Guchelaar, Henk-Jan
    Leiden University, Netherlands.
    Guo, Yi-Ke
    University of London Imperial Coll Science Technology and Med, England.
    Glynne Gut, Ivo
    BIST, Spain.
    Hanbury, Allan
    TU Wien, Austria.
    Hanif, Shahid
    Assoc British Pharmaceut Ind, England.
    Hilgers, Ralf-Dieter
    University of Klinikum Aachen, Germany.
    Honrado, Angel
    SYNAPSE Research Management Partners, Spain.
    Rod Hose, D.
    University of Sheffield, England.
    Houwing-Duistermaat, Jeanine
    University of Leeds, England.
    Hubbard, Tim
    Kings Coll London, England; Genom England, England.
    Helen Janacek, Sophie
    European Bioinformat Institute EMBL EBI, England.
    Karanikas, Haralampos
    University of Athens, Greece.
    Kievits, Tim
    Vitr Healthcare Holding BV, Netherlands.
    Kohler, Manfred
    Fraunhofer Institute Molecular Biol and Appl Ecol ScreeningPor, Germany.
    Kremer, Andreas
    ITTM SA, Luxembourg.
    Lanfear, Jerry
    Pfizer Ltd, England.
    Lengauer, Thomas
    Max Planck Institute for Informatics, Saarbrucken, Germany.
    Maes, Edith
    Health Econ and Outcomes Research, Belgium.
    Meert, Theo
    Janssen Pharmaceut NV, Belgium.
    Mueller, Werner
    University of Manchester, England.
    Nickel, Dorthe
    Institute Curie, France.
    Oledzki, Peter
    Linguamat Ltd, England.
    Pedersen, Bertrand
    PwC Luxembourg, Luxembourg.
    Petkovic, Milan
    Philips, Netherlands.
    Pliakos, Konstantinos
    KU Leuven Kulak, Belgium.
    Rattray, Magnus
    University of Manchester, England.
    Redon i Mas, Josep
    University of Valencia, Spain.
    Schneider, Reinhard
    University of Luxembourg, Luxembourg.
    Sengstag, Thierry
    SIB, Switzerland; University of Basel, Switzerland.
    Serra-Picamal, Xavier
    Agency Health Qual and Assessment Catalonia AQuAS, Spain.
    Spek, Wouter
    EuroBioForum Fdn, Netherlands.
    Vaas, Lea A. I.
    Fraunhofer Institute Molecular Biol and Appl Ecol ScreeningPor, Germany.
    van Batenburg, Okker
    EuroBioForum Fdn, Netherlands.
    Vandelaer, Marc
    Integrated BioBank Luxembourg, Luxembourg.
    Varnai, Peter
    Technopolis Grp, England.
    Villoslada, Pablo
    Hospital Clin Barcelona, Spain.
    Antonio Vizcaino, Juan
    European Bioinformat Institute EMBL EBI, England.
    Peter Mary Wubbe, John
    European Platform Patients Org Science and Ind Epposi, Belgium.
    Zanetti, Gianluigi
    CRS4, Italy; BBMRI ERIC, Austria.
    Making sense of big data in health research: Towards an EU action plan2016Ingår i: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 8, nr 71Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation combined with automation and miniaturization has triggered an explosion in data production that will soon reach exabyte proportions. How are we going to deal with this exponential increase in data production? The potential of "big data" for improving health is enormous but, at the same time, we face a wide range of challenges to overcome urgently. Europe is very proud of its cultural diversity; however, exploitation of the data made available through advances in genomic medicine, imaging, and a wide range of mobile health applications or connected devices is hampered by numerous historical, technical, legal, and political barriers. European health systems and databases are diverse and fragmented. There is a lack of harmonization of data formats, processing, analysis, and data transfer, which leads to incompatibilities and lost opportunities. Legal frameworks for data sharing are evolving. Clinicians, researchers, and citizens need improved methods, tools, and training to generate, analyze, and query data effectively. Addressing these barriers will contribute to creating the European Single Market for health, which will improve health arid healthcare for all Europearis.

  • 16.
    Mattson, Lina
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Lentini, Antonio
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Gawel, Danuta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Badam, Tejaswi
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Ledin, Torbjörn
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Sinnescentrum, Öron- näsa- och halskliniken US.
    Nestor, Colm
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Gustafsson, Mika
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Serra I Musach, Jordi
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Björkander, Janne
    County Council Jonköping, Sweden.
    Xiang, Zou
    Hong Kong Polytech University, Peoples R China.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Potential Involvement of Type I Interferon Signaling in Immunotherapy in Seasonal Allergic Rhinitis2016Ingår i: Journal of Immunology Research, ISSN 2314-8861, E-ISSN 2314-7156, artikel-id 5153184Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Specific immunotherapy (SIT) reverses the symptoms of seasonal allergic rhinitis (SAR) in most patients. Recent studies report type I interferons shifting the balance between type I T helper cell (Th1) and type II T helper cells (Th2) towards Th2 dominance by inhibiting the differentiation of naive Tcells into Th1 cells. As SIT is thought to cause a shift towardsTh1 dominance, we hypothesized that SIT would alter interferon type I signaling. To test this, allergen and diluent challenged CD4(+) T cells from healthy controls and patients from different time points were analyzed. The initial experiments focused on signature genes of the pathway and found complex changes following immunotherapy, which were consistent with our hypothesis. As interferon signaling involves multiple genes, expression profiling studies were performed, showing altered expression of the pathway. These findings require validation in a larger group of patients in further studies.

  • 17.
    Bousquet, J.
    et al.
    CHRU, France; MACVIA LR, France; INSERM, France; University of Versailles St Quentin En Yvelines, France.
    Farrell, J.
    Department Health Social Serv and Public Safety, North Ireland.
    Crooks, G.
    Scottish Centre Telehealth and Telecare, Scotland.
    Hellings, P.
    Katholieke University of Leuven, Belgium; European Academic Allergy and Clin Immunol, Switzerland.
    Bel, E. H.
    University of Amsterdam, Netherlands; European Resp Soc, Switzerland.
    Bewick, M.
    iQ4U Consultants Ltd, England.
    Chavannes, N. H.
    Leiden University, Netherlands; Global Alliance Chron Resp Disease GARD, South Africa; Int Primary Care Resp Grp, Scotland.
    Correia de Sousa, J.
    University of Minho, Portugal.
    Cruz, A. A.
    Global Alliance Chron Resp Disease GARD, South Africa; University of Federal Bahia, Brazil; GARD Execut Comm, Brazil.
    Haahtela, T.
    EIP AHA Commitment Act, Portugal; Helsinki University Hospital, Finland.
    Joos, G.
    Ghent University Hospital, Belgium.
    Khaltaev, N.
    Global Alliance Chron Resp Disease GARD, South Africa.
    Malva, J.
    University of Coimbra, Portugal; Ageing Coimbra Reference Site, Portugal.
    Muraro, A.
    European Academic Allergy and Clin Immunol, Switzerland; Padua Gen University Hospital, Italy.
    Nogues, M.
    CARSAT LR, France.
    Palkonen, S.
    EFA European Federat Allergy and Airways Disease Patien, Belgium.
    Pedersen, S.
    University of Southern Denmark, Denmark.
    Robalo-Cordeiro, C.
    Coimbra University Hospital, Portugal.
    Samolinski, B.
    Medical University of Warsaw, Poland.
    Strandberg, T.
    University of Helsinki, Finland; University of Oulu, Finland; EUGMS, Norway.
    Valiulis, A.
    Vilnius University, Lithuania; European Assoc Pediat EAP UEMS SP, Belgium.
    Yorgancioglu, A.
    Global Alliance Chron Resp Disease GARD, South Africa; EIP AHA Commitment Act, Portugal; Celal Bayar University, Turkey; Turkish Thorac Soc, Turkey.
    Zuberbier, T.
    Charite, Germany; GA2LEN, Germany.
    Bedbrook, A.
    MACVIA LR, France.
    Aberer, W.
    Medical University of Graz, Austria.
    Adachi, M.
    Sanno Hospital, Japan.
    Agusti, A.
    University of Barcelona, Spain; CIBER Enfermedades Resp, Spain.
    Akdis, C. A.
    University of Zurich, Switzerland.
    Akdis, M.
    University of Zurich, Switzerland.
    Ankri, J.
    INSERM, France; University of Versailles St Quentin En Yvelines, France.
    Alonso, A.
    University of Barcelona, Spain; CIBER Enfermedades Resp, Spain.
    Annesi-Maesano, I.
    European Assoc Pediat EAP UEMS SP, Belgium; INSERM, France.
    Ansotegui, I. J.
    Hospital Quiron Bizkaia, Spain.
    Anto, J. M.
    Centre Research Environm Epidemiol CREAL, Spain; Hospital del Mar, Spain; CIBERESP, Spain; UPF, Spain.
    Arnavielhe, S.
    Digi Heatlh, France.
    Arshad, H.
    David Hide Asthma and Allergy Research Centre, England.
    Bai, C.
    Chinese Medical Assoc, Peoples R China; Chinese Alliance Lung Canc, Peoples R China.
    Baiardini, I.
    University of Genoa, Italy.
    Bachert, C.
    Ghent University Hospital, Belgium.
    Baigenzhin, A. K.
    EuroAsian Resp Soc, Kazakhstan.
    Barbara, C.
    Fac Medical Lisbon, Portugal.
    Bateman, E. D.
    University of Cape Town, South Africa.
    Beghe, B.
    University of Modena and Reggio Emilia, Italy.
    Ben Kheder, A.
    Hop Abderrahman Mami, Tunisia.
    Bennoor, K. S.
    National Institute Disease Chest and Hospital, Bangladesh.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Bergmann, K. C.
    Charite, Germany; GA2LEN, Germany.
    Bieber, T.
    Rheinische Friedrich Wilhelms University of Bonn, Germany.
    Bindslev-Jensen, C.
    Odense University Hospital, Denmark; Odense University Hospital, Denmark.
    Bjermer, L.
    University Hospital, Sweden.
    Blain, H.
    Montpellier University Hospital, France; University of Montpellier, France.
    Blasi, F.
    University of Milan, Italy.
    Boner, A. L.
    University of Verona Hospital, Italy.
    Bonini, M.
    Sapienza University of Rome, Italy.
    Bonini, S.
    University of Naples 2, Italy; Italian National Research Council, Italy.
    Bosnic-Anticevitch, S.
    University of Sydney, Australia; Sydney Local Health Dist, Australia.
    Boulet, L. P.
    University of Laval, Canada.
    Bourret, R.
    Montpellier University Hospital, France.
    Bousquet, P. J.
    INSERM, France.
    Braido, F.
    University of Genoa, Italy.
    Briggs, A. H.
    University of Glasgow, Scotland.
    Brightling, C. E.
    University Hospital Leicester NHS Trust, England; University of Leicester, England.
    Brozek, J.
    McMaster University, Canada.
    Buhl, R.
    Johannes Gutenberg University of Mainz, Germany.
    Burney, P. G.
    Imperial Coll, England; Imperial Coll, England; Imperial Coll, England.
    Bush, A.
    Imperial Coll, England; Royal Brompton Hospital, England.
    Caballero-Fonseca, F.
    Centre Medical Docente Trinidad, Venezuela.
    Caimmi, D.
    Montpellier University Hospital, France.
    Calderon, M. A.
    Royal Brompton Hospital NHS, England.
    Calverley, P. M.
    University of Liverpool, England; Aintree University Hospital NHS Fdn Trust, England.
    Camargos, P. A. M.
    University of Federal Minas Gerais, Brazil.
    Canonica, G. W.
    University of Genoa, Italy.
    Camuzat, T.
    Regional Languedoc Roussillon, France.
    Carlsen, K. H.
    Oslo University Hospital, Norway; University of Oslo, Norway; Oslo University Hospital, Norway; University of Oslo, Norway.
    Carr, W.
    Allergy and Asthma Associates Southern Calif, CA USA.
    Carriazo, A.
    Regional Minist Equal Health and Social Policies Andalusia, Spain.
    Casale, T.
    University of S Florida, FL USA.
    Cepeda Sarabia, A. M.
    University of Simon Bolivar, Colombia; Soc Latinoamer Allergia, Colombia.
    Chatzi, L.
    University of Crete, Greece.
    Chen, Y. Z.
    Peking and Centre Asthma Research and Educ, Peoples R China; Peking and Centre Asthma Research and Educ, Peoples R China.
    Chiron, R.
    Montpellier University Hospital, France.
    Chkhartishvili, E.
    Grigol Robakidze University, Rep of Georgia.
    Chuchalin, A. G.
    GARD Execut Comm, Brazil; FMBA, Russia.
    Chung, K. F.
    Imperial Coll, England.
    Ciprandi, G.
    IRCCS Azienda Osped University of San Martino, Italy.
    Cirule, I.
    Latvian Allergy Assoc, Latvia.
    Cox, L.
    Nova Southeastern University, FL USA.
    Costa, D. J.
    MACVIA LR, France; Leiden University, Netherlands.
    Custovic, A.
    Imperial Coll London, England.
    Dahl, R.
    Odense University Hospital, Denmark; Odense University Hospital, Denmark.
    Dahlen, S. E.
    Karolinska Institute, Sweden.
    Darsow, U.
    Technical University of Munich, Germany; Technical University of Munich, Germany.
    De Carlo, G.
    EFA European Federat Allergy and Airways Disease Patien, Belgium.
    De Blay, F.
    University Hospital Strasbourg, France.
    Dedeu, T.
    European Regional and Local Health Assoc, Belgium; University of Edinburgh, Scotland.
    Deleanu, D.
    Iuliu Hatieganu University of Medical and Pharm, Romania.
    De Manuel Keenoy, E.
    Kronikgune, Spain.
    Demoly, P.
    INSERM, France; Montpellier University Hospital, France.
    Denburg, J. A.
    McMaster University, Canada.
    Devillier, P.
    Suresnes University of Versailles St Quentin, France.
    Didier, A.
    Rangueil Larrey Hospital, France.
    Dinh-Xuan, A. T.
    University of Paris 05, France.
    Djukanovic, R.
    University of Southampton, England.
    Dokic, D.
    University of Clin Pulmol and Allergy, Macedonia.
    Douagui, H.
    Centre Hospital University of Beni Messous, Algeria.
    Dray, G.
    Ecole Mines, France.
    Dubakiene, R.
    Vilnius University, Lithuania.
    Durham, S. R.
    Imperial Coll London, England.
    Dykewicz, M. S.
    St Louis University, MO USA.
    El-Gamal, Y.
    Ain Shams University, Egypt.
    Emuzyte, R.
    Vilnius University, Lithuania.
    Fabbri, L. M.
    University of Modena, Italy.
    Fletcher, M.
    Educ Heatlh, England.
    Fiocchi, A.
    Bambino Gesu Childrens Research Hospital Holy See, Italy.
    Fink Wagner, A.
    GAAPP, Austria.
    Fonseca, J.
    University of Porto, Portugal; CUF Porto Institute and Hospital, Portugal.
    Fokkens, W. J.
    Academic Medical Centre, Netherlands.
    Forastiere, F.
    Regional Health Serv Lazio Reg, Italy.
    Frith, P.
    Repatriat Gen Hospital, Australia.
    Gaga, M.
    Athens Chest Hospital, Greece.
    Gamkrelidze, A.
    National Centre Disease Control and Public Health Georgia, Rep of Georgia.
    Garces, J.
    University of Valencia, Spain.
    Garcia-Aymerich, J.
    Centre Research Environm Epidemiol CREAL, Spain; Hospital del Mar, Spain; CIBERESP, Spain; UPF, Spain.
    Gemicioglu, B.
    Istanbul University, Turkey.
    Gereda, J. E.
    Clin Ricardo Palma, Peru.
    Gonzalez Diaz, S.
    University of Autonoma Nuevo Leon, Mexico.
    Gotua, M.
    Georgian Assoc Allergol and Clin Immunol, Rep of Georgia.
    Grisle, I.
    Latvian Assoc Allergists, Latvia.
    Grouse, L.
    Washington University, MO 63110 USA.
    Gutter, Z.
    University Hospital Olomouc, Czech Republic.
    Guzman, M. A.
    University of Chile, Chile.
    Heaney, L. G.
    Queens University of Belfast, North Ireland.
    Hellquist-Dahl, B.
    Odense University Hospital, Denmark.
    Henderson, D.
    Scottish Centre Telehealth and Telecare, Scotland.
    Hendry, A.
    NHS Scotland, Scotland.
    Heinrich, J.
    Helmholtz Zentrum Munchen, Germany.
    Heve, D.
    MACVIA LR, France; Agence Regional Sante, France.
    Horak, F.
    Vienna Challenge Chamber, Austria.
    Hourihane, J. O. B.
    University of Coll Cork, Ireland.
    Howarth, P.
    University of Southampton, England.
    Humbert, M.
    University of Paris Sud, France.
    Hyland, M. E.
    University of Plymouth, England.
    Illario, M.
    Federico II University Hospital Campania RS, Italy.
    Ivancevich, J. C.
    Clin Santa Isabel, Argentina.
    Jardim, J. R.
    University of Federal Sao Paulo, Brazil.
    Jares, E. J.
    Libra Fdn, Argentina.
    Jeandel, C.
    MACVIA LR, France; Montpellier University Hospital, France.
    Jenkins, C.
    University of Sydney, Australia.
    Johnston, S. L.
    Imperial Coll, England; MRC and Asthma UK Centre Allerg Mech Asthma, England.
    Jonquet, O.
    Montpellier University Hospital, France.
    Julge, K.
    Tartu University Hospital, Estonia.
    Jung, K. S.
    Hallym University, South Korea.
    Just, J.
    Hop Enfants Armand Trousseau, France; Sorbonne University, France.
    Kaidashev, I.
    Ukrainian Medical Stomatol Acad, Ukraine.
    Kaitov, M. R.
    Federal Medicobiol Agency, Russia.
    Kalayci, O.
    Hacettepe University, Turkey.
    Kalyoncu, A. F.
    Hacettepe University, Turkey.
    Keil, T.
    Charite, Germany; University of Wurzburg, Germany.
    Keith, P. K.
    McMaster University, Canada.
    Klimek, L.
    Centre Rhinol and Allergol, Germany.
    Koffi NGoran, B.
    Soc Pneumol Langue Francaise, France.
    Kolek, V.
    University Hospital Olomouc, Czech Republic.
    Koppelman, G. H.
    University of Groningen, Netherlands.
    Kowalski, M. L.
    Medical University of Lodz, Poland; HARC, Poland.
    Kull, I.
    Sachs Childrens Hospital, Sweden; Karolinska Institute, Sweden.
    Kuna, P.
    Medical University of Lodz, Poland.
    Kvedariene, V.
    Vilnius University, Lithuania.
    Lambrecht, B.
    University of Ghent, Belgium.
    Lau, S.
    Charite, Germany.
    Larenas-Linnemann, D.
    Hospital Medical Sur, Mexico.
    Laune, D.
    Digi Heatlh, France.
    Le, L. T. T.
    University of Medical and Pharm, Vietnam.
    Lieberman, P.
    University of Tennessee, TN USA; University of Tennessee, TN USA; University of Tennessee, TN USA; University of Tennessee, TN USA.
    Lipworth, B.
    University of Dundee, Scotland.
    Li, J.
    Guangzhou Medical University, Peoples R China.
    Lodrup Carlsen, K.
    Oslo University Hospital, Norway; University of Oslo, Norway; Oslo University Hospital, Norway; University of Oslo, Norway.
    Louis, R.
    CHU Sart Tilman, Belgium.
    MacNee, W.
    University of Edinburgh, Scotland.
    Magard, Y.
    Hop St Joseph, France.
    Magnan, A.
    University of Nantes, France; University of Nantes, France.
    Mahboub, B.
    Rashid Hospital, U Arab Emirates.
    Mair, A.
    Scottish Govt Health Department, Scotland.
    Majer, I.
    University of Bratislava, Slovakia.
    Makela, M. J.
    Helsinki University Hospital, Finland.
    Manning, P.
    Bon Secours Hospital, Ireland.
    Mara, S.
    AOU Citta Salute and Science Torino, Italy.
    Marshall, G. D.
    University of Mississippi, MS 39216 USA.
    Masjedi, M. R.
    Shahid Beheshti University of Medical Science, Iran.
    Matignon, P.
    VingCard Elsafe, Norway.
    Maurer, M.
    Charite, Germany.
    Mavale-Manuel, S.
    Maputo Central Hospital, Mozambique.
    Melen, E.
    Karolinska Institute, Sweden.
    Melo-Gomes, E.
    PNDR Portuguese National Programme Resp Disease, Portugal.
    Meltzer, E. O.
    Allergy and Asthma Medical Grp and Research Centre, CA USA.
    Menzies-Gow, A.
    Royal Brompton Hospital, England.
    Merk, H.
    Rhein Westfal TH Aachen, Germany.
    Michel, J. P.
    EUGMS, Norway.
    Miculinic, N.
    Croatian Pulm Soc, Croatia.
    Mihaltan, F.
    National Institute Pneumol M Nasta, Romania.
    Milenkovic, B.
    University of Belgrade, Serbia; Serbian Assoc Asthma, Serbia; COPD, Serbia.
    Mohammad, G. M. Y.
    Tishreen University, Syria.
    Molimard, M.
    University of Bordeaux, France.
    Momas, I.
    Paris Descartes University, France; Paris Municipal Department Social Act Childhood and Heatlh, France.
    Montilla-Santana, A.
    Aura Andalucia, Spain.
    Morais-Almeida, M.
    Hospital CUF Descobertas, Portugal.
    Morgan, M.
    NHS England, England.
    Mosges, R.
    University of Cologne, Germany.
    Mullol, J.
    Sachs Childrens Hospital, Sweden; Karolinska Institute, Sweden; Hospital Clin Barcelona, Spain.
    Nafti, S.
    Mustapha Hospital, Algeria.
    Namazova-Baranova, L.
    Russian Academic Medical Science, Russia.
    Naclerio, R.
    University of Chicago, IL 60637 USA; University of Chicago, IL 60637 USA.
    Neou, A.
    Charite, Germany; GA2LEN, Germany.
    Neffen, H.
    Hospital Ninos Orlando Alassia, Argentina.
    Nekam, K.
    Hospital Hospitaller Bros Buda, Hungary.
    Niggemann, B.
    Charite, Germany.
    Ninot, G.
    University of Montpellier I, France.
    Nyembue, T. D.
    University Hospital Kinshasa, DEM REP CONGO.
    OHehir, R. E.
    Monash University, Australia; Monash University, Australia; Monash University, Australia.
    Ohta, K.
    Tokyo National Hospital, Japan.
    Okamoto, Y.
    Chiba University Hospital, Japan.
    Okubo, K.
    Nippon Medical Sch, Japan.
    Ouedraogo, S.
    Centre Hospital University of Pediat Charles de Gaulle, Burkina Faso.
    Paggiaro, P.
    University Hospital Pisa, Italy.
    Pali-Scholl, I.
    University of Vet Med, Austria; Medical University, Austria.
    Panzner, P.
    Charles University of Prague, Czech Republic; Charles University of Prague, Czech Republic.
    Papadopoulos, N.
    University of Manchester, England; University of Athens, Greece.
    Papi, A.
    University of Ferrara, Italy.
    Park, H. S.
    Ajou University, South Korea.
    Passalacqua, G.
    University of Genoa, Italy.
    Pavord, I.
    University of Oxford, England.
    Pawankar, R.
    Nippon Medical Sch, Japan.
    Pengelly, R.
    Department Health Social Serv and Public Safety, North Ireland.
    Pfaar, O.
    Centre Rhinol and Allergol, Germany; Heidelberg University, Germany.
    Picard, R.
    Minist Econ Ind and Numer, France.
    Pigearias, B.
    Soc Pneumol Langue Francaise, France.
    Pin, I.
    CHU Grenoble, France.
    Plavec, D.
    University of JJ Strossmayer, Croatia.
    Poethig, D.
    Europe Europa Vereinigung Vitalitat and Aktives Alt, Germany.
    Pohl, W.
    Hietzing Hospital, Austria.
    Popov, T. A.
    Medical University of Sofia, Bulgaria.
    Portejoie, F.
    MACVIA LR, France.
    Potter, P.
    University of Cape Town, South Africa.
    Postma, D.
    University of Groningen, Netherlands.
    Price, D.
    University of Aberdeen, Scotland; Research Real Life, England.
    Rabe, K. F.
    German Centre Lung Research DZL, Germany; University of Kiel, Germany; German Centre Lung Research DZL, Germany.
    Raciborski, F.
    Medical University of Warsaw, Poland.
    Radier Pontal, F.
    Maison Profess Liberales, France.
    Repka-Ramirez, S.
    SLAAI, Colombia.
    Reitamo, S.
    Helsinki University Hospital, Finland.
    Rennard, S.
    University of Nebraska Medical Centre, NE USA.
    Rodenas, F.
    University of Valencia, Spain.
    Roberts, J.
    Salford Royal NHS Fdn Trust and NHS England North, England.
    Roca, J.
    University of Barcelona, Spain.
    Rodriguez Manas, L.
    Hospital University of Getafe Serv Madrileno Salud, Spain.
    Rolland, C.
    Assoc Asthme and Allergie, France.
    Roman Rodriguez, M.
    Institute Invest Sanitaria Palma IdisPa, Spain.
    Romano, A.
    Complesso Integrato Columbus, Italy.
    Rosado-Pinto, J.
    Hospital Luz, Portugal.
    Rosario, N.
    University of Parana, Brazil.
    Rosenwasser, L.
    Medical University of Misouri Kansas City, MO USA; Medical University of Misouri Kansas City, MO USA.
    Rottem, M.
    Emek Medical Centre, Israel.
    Ryan, D.
    Woodbrook Medical Centre, England; University of Edinburgh, Scotland.
    Sanchez-Borges, M.
    Centre Medicodocente Trinidad and Clin El Avila, Venezuela.
    Scadding, G. K.
    UCL, England.
    Schunemann, H. J.
    McMaster University, Canada.
    Serrano, E.
    CHU Rangueil Larrey, France.
    Schmid-Grendelmeier, P.
    University of Zurich Hospital, Switzerland.
    Schulz, H.
    Helmholtz Zentrum Munchen, Germany.
    Sheikh, A.
    University of Edinburgh, Scotland.
    Shields, M.
    Queens University of Belfast, North Ireland; Royal Belfast Hospital Sick Children, North Ireland.
    Siafakas, N.
    University Hospital Heraklion, Greece.
    Sibille, Y.
    Catholic University of Louvain, Belgium.
    Similowski, T.
    Sorbonne University, France; INSERM, France; Groupe, France.
    Simons, F. E. R.
    University of Manitoba, Canada.
    Sisul, J. C.
    Soc Paraguaya Alergia Asma and Inmunol, Paraguay.
    Skrindo, I.
    Oslo University Hospital, Norway; University of Oslo, Norway.
    Smit, H. A.
    University of Utrecht, Netherlands.
    Sole, D.
    University of Federal Sao Paulo, Brazil.
    Sooronbaev, T.
    Euro Asian Resp Soc, Kyrgyzstan.
    Spranger, O.
    GAAPP, Austria.
    Stelmach, R.
    University of Sao Paulo, Brazil.
    Sterk, P. J.
    University of Amsterdam, Netherlands.
    Sunyer, J.
    Centre Research Environm Epidemiol CREAL, Spain; CIBERESP, Spain; UPF, Spain.
    Thijs, C.
    Maastricht University, Netherlands.
    To, T.
    Sidkkids Hospital and Institute Health Policy Management and Eva, Canada.
    Todo-Bom, A.
    University of Coimbra, Portugal.
    Triggiani, M.
    University of Salerno, Italy.
    Valenta, R.
    Medical University of Vienna, Austria.
    Valero, A. L.
    Hospital Clin Barcelona, Spain.
    Valia, E.
    University of Valencia, Spain.
    Valovirta, E.
    University of Turku, Finland.
    Van Ganse, E.
    University of Claude Bernard, France.
    van Hage, M.
    Karolinska Institute, Sweden; University Hospital, Sweden.
    Vandenplas, O.
    Catholic University of Louvain, Belgium.
    Vasankari, T.
    Finnish Lung Assoc, Finland.
    Vellas, B.
    CHU Toulouse, France.
    Vestbo, J.
    University of Manchester, England; Manchester NHS Fdn Trust, England.
    Vezzani, G.
    Arcispedale S Maria Nuova, Italy; Regional Agency Health and Social Care, Italy.
    Vichyanond, P.
    Mahidol University, Thailand.
    Viegi, G.
    CNR, Italy; CNR, Italy.
    Vogelmeier, C.
    Philipps University of Marburg, Germany.
    Vontetsianos, T.
    Sotiria Hospital, Greece.
    Wagenmann, M.
    University of Klinikum Dusseldorf, Germany.
    Wallaert, B.
    CHRU, France.
    Walker, S.
    Asthma UK, England.
    Wang, D. Y.
    National University of Singapore, Singapore.
    Wahn, U.
    Charite, Germany.
    Wickman, M.
    Karolinska Institute, Sweden.
    Williams, D. M.
    University of N Carolina, NC USA.
    Williams, S.
    Int Primary Care Resp Grp, Scotland.
    Wright, J.
    Bradford Royal Infirm, England.
    Yawn, B. P.
    Olmsted Medical Centre, MN USA.
    Yiallouros, P. K.
    Cyprus University of Technology, Cyprus; Hospital Archbishop Makarios III, Cyprus.
    Yusuf, O. M.
    Allergy and Asthma Institute, Pakistan.
    Zaidi, A.
    University of Southampton, England.
    Zar, H. J.
    University of Cape Town, South Africa; University of Cape Town, South Africa.
    Zernotti, M. E.
    University of Catolica Cordoba, Argentina.
    Zhang, L.
    Capital Medical University, Peoples R China.
    Zhong, N.
    Guangzhou Medical University, Peoples R China.
    Zidarn, M.
    University of Clin Resp and Allerg Disease, Slovenia.
    Mercier, J.
    CHRU, France; University of Montpellier, France.
    Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)2016Ingår i: Clinical and Translational Allergy, ISSN 2045-7022, E-ISSN 2045-7022, Vol. 6, artikel-id 29Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un Vleillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing.

  • 18.
    Gustafsson, Mika
    et al.
    Linköpings universitet, Institutionen för fysik, kemi och biologi, Bioinformatik. Linköpings universitet, Tekniska fakulteten.
    Gawel, Danuta
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Alfredsson, Lars
    Karolinska Institute, Sweden.
    Baranzini, Sergio
    University of Calif San Francisco, CA, USA.
    Bjorkander, Janne
    County Council Jonköping, Sweden.
    Blomgran, Robert
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Medicinska fakulteten.
    Hellberg, Sandra
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Eklund, Daniel
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
    Ernerudh, Jan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
    Kockum, Ingrid
    Karolinska Institute, Sweden; Centre Molecular Med, Sweden.
    Konstantinell, Aelita
    Linköpings universitet, Medicinska fakulteten. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Arctic University of Norway, Norway.
    Lahesmaa, Riita
    University of Turku, Finland; Abo Akad University, Finland.
    Lentini, Antonio
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Liljenström, H. Robert I.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Mattson, Lina
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Matussek, Andreas
    County Council Jonköping, Sweden.
    Mellergård, Johan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Närsjukvården i centrala Östergötland, Neurologiska kliniken.
    Mendez, Melissa
    University of Peruana Cayetano Heredia, Peru.
    Olsson, Tomas
    Karolinska Institute, Sweden; Centre Molecular Med, Sweden.
    Pujana, Miguel A.
    Catalan Institute Oncol, Spain.
    Rasool, Omid
    University of Turku, Finland; Abo Akad University, Finland.
    Serra-Musach, Jordi
    Catalan Institute Oncol, Spain.
    Stenmarker, Margaretha
    County Council Jonköping, Sweden.
    Tripathi, Subhash
    University of Turku, Finland; Abo Akad University, Finland.
    Viitala, Miro
    University of Turku, Finland; Abo Akad University, Finland.
    Wang, Hui
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. University of Texas MD Anderson Cancer Centre, TX 77030 USA.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Nestor, Colm
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases2015Ingår i: Science Translational Medicine, ISSN 1946-6234, E-ISSN 1946-6242, Vol. 7, nr 313, artikel-id 313ra178Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Early regulators of disease may increase understanding of disease mechanisms and serve as markers for presymptomatic diagnosis and treatment. However, early regulators are difficult to identify because patients generally present after they are symptomatic. We hypothesized that early regulators of T cell-associated diseases could be found by identifying upstream transcription factors (TFs) in T cell differentiation and by prioritizing hub TFs that were enriched for disease-associated polymorphisms. A gene regulatory network (GRN) was constructed by time series profiling of the transcriptomes and methylomes of human CD4(+) T cells during in vitro differentiation into four helper T cell lineages, in combination with sequence-based TF binding predictions. The TFs GATA3, MAF, and MYB were identified as early regulators and validated by ChIP-seq (chromatin immunoprecipitation sequencing) and small interfering RNA knockdowns. Differential mRNA expression of the TFs and their targets in T cell-associated diseases supports their clinical relevance. To directly test if the TFs were altered early in disease, T cells from patients with two T cell-mediated diseases, multiple sclerosis and seasonal allergic rhinitis, were analyzed. Strikingly, the TFs were differentially expressed during asymptomatic stages of both diseases, whereas their targets showed altered expression during symptomatic stages. This analytical strategy to identify early regulators of disease by combining GRNs with genome-wide association studies may be generally applicable for functional and clinical studies of early disease development.

  • 19.
    Bousquet, J.
    et al.
    University Hospital, France; European Innovat Partnership Act and Health Ageing Re, France; INSERM, France; University of Versailles St Quentin En Yvelines UVSQ, France.
    Schunemann, H. J.
    McMaster University, Canada.
    Fonseca, J.
    University of Porto, Portugal; University of Porto, Portugal; University of Porto, Portugal; University of Porto, Portugal; University of Porto, Portugal.
    Samolinski, B.
    Medical University of Warsaw, Poland.
    Bachert, C.
    Ghent University Hospital, Belgium.
    Canonica, G. W.
    University of Genoa, Italy.
    Casale, T.
    University of S Florida, FL USA.
    Cruz, A. A.
    University of Federal Bahia, Brazil; GARD Execut Comm, Brazil.
    Demoly, P.
    Montpellier University Hospital, France; INSERM, France; UPMC, France.
    Hellings, P.
    Katholieke University of Leuven, Belgium.
    Valiulis, A.
    Vilnius University, Lithuania.
    Wickman, M.
    Sachs Childrens Hospital, Sweden; Karolinska Institute, Sweden.
    Zuberbier, T.
    Charite, Germany.
    Bosnic-Anticevitch, S.
    University of Sydney, Australia; Sydney Local Health Dist, Australia.
    Bedbrook, A.
    European Innovat Partnership Act and Health Ageing Re, France.
    Bergmann, K. C.
    Charite, Germany.
    Caimmi, D.
    Montpellier University Hospital, France.
    Dahl, R.
    Odense University Hospital, Denmark; Odense University Hospital, Denmark.
    Fokkens, W. J.
    University of Amsterdam, Netherlands.
    Grisle, I.
    Latvian Assoc Allergists, Latvia.
    Lodrup Carlsen, K.
    Oslo University Hospital, Norway; .
    Mullol, J.
    IDIBAPS, Spain.
    Muraro, A.
    Padua Gen University Hospital, Italy.
    Palkonen, S.
    EFA European Federat Allergy and Airways Disease Patien, Belgium.
    Papadopoulos, N.
    University of Manchester, England; University of Athens, Greece.
    Passalacqua, G.
    University of Genoa, Italy.
    Ryan, D.
    Woodbrook Medical Centre, England; University of Edinburgh, Scotland.
    Valovirta, E.
    University of Turku, Finland.
    Yorgancioglu, A.
    Celal Bayar University, Turkey.
    Aberer, W.
    Medical University of Graz, Austria.
    Agache, I.
    Transylvania University of Brasov, Romania.
    Adachi, M.
    Int University of Health and Welfare, Japan.
    Akdis, C. A.
    University of Zurich, Switzerland.
    Akdis, M.
    University of Zurich, Switzerland.
    Annesi-Maesano, I.
    INSERM, France; UPMC, France.
    Ansotegui, I. J.
    Hospital Quiron Bizkaia, Spain.
    Anto, J. M.
    Centre Research Environm Epidemiol, Spain; Hospital del Mar, Spain; CIBER Epidemiol and Salud Publ, Spain; University of Pompeu Fabra, Spain.
    Arnavielhe, S.
    Digi Heatlh, France.
    Arshad, H.
    David Hide Asthma and Allergy Research Centre, England.
    Baiardini, I.
    University of Genoa, Italy.
    Baigenzhin, A. K.
    EuroAsian Resp Soc, Kazakhstan.
    Barbara, C.
    Fac Medical Lisbon, Portugal.
    Bateman, E. D.
    University of Cape Town, South Africa.
    Beghe, B.
    University of Modena and Reggio Emilia, Italy.
    Bel, E. H.
    University of Amsterdam, Netherlands.
    Ben Kheder, A.
    Hop Abderrahman Mami, Tunisia.
    Bennoor, K. S.
    National Institute Disease Chest and Hospital, Bangladesh.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Bewick, M.
    Bieber, T.
    University of Bonn, Germany.
    Bindslev-Jensen, C.
    Odense University Hospital, Denmark;.
    Bjermer, L.
    University of Lund Hospital, Sweden.
    Blain, H.
    University of Montpellier, France; .
    Boner, A. L.
    University of Verona Hospital, Italy.
    Boulet, L. P.
    University of Laval, Canada.
    Bonini, M.
    University of Roma La Sapienza, Italy.
    Bonini, S.
    University of Naples 2, Italy; Italian National Research Council, Italy.
    Bosse, I.
    Bourret, R.
    Montpellier University Hospital, France.
    Bousquet, P. J.
    INSERM, France; UPMC, France.
    Braido, F.
    University of Genoa, Italy.
    Briggs, A. H.
    University of Glasgow, Scotland.
    Brightling, C. E.
    University Hospital Leicester NHS Trust, England; University of Leicester, England.
    Brozek, J.
    McMaster University, Canada.
    Buhl, R.
    Johannes Gutenberg University of Mainz, Germany.
    Burney, P. G.
    University of London Imperial Coll Science Technology and Med, England; University of London Imperial Coll Science Technology and Med, England; University of London Imperial Coll Science Technology and Med, England.
    Bush, A.
    University of London Imperial Coll Science Technology and Med, England; Royal Brompton Hospital, England.
    Caballero-Fonseca, F.
    Centre Medical Docente La Trinidad, Venezuela.
    Calderon, M. A.
    University of London Imperial Coll Science Technology and Med, England.
    Camargos, P. A. M.
    University of Federal Minas Gerais, Brazil.
    Camuzat, T.
    Regional Languedoc Roussillon, France.
    Carlsen, K. H.
    Oslo University Hospital, Norway; .
    Carr, W.
    Allergy and Asthma Associates Southern Calif, CA USA.
    Cepeda Sarabia, A. M.
    University of Simon Bolivar, Colombia; SLaai, Colombia.
    Chavannes, N. H.
    Leiden University, Netherlands.
    Chiron, R.
    Montpellier University Hospital, France.
    Chkhartishvili, E.
    Grigol Robakidze University, Rep of Georgia.
    Chuchalin, A. G.
    Pulmonolory Research Institute FMBA, Russia; GARD Execut Comm, Russia.
    Ciprandi, G.
    Azienda Osped University of San Martino, Italy.
    Cirule, I.
    University of Children Hospital Latvia, Latvia.
    Correia de Sousa, J.
    University of Minho, Portugal.
    Cox, L.
    Nova SE University, FL USA.
    Crooks, G.
    NHS Scotland, Scotland.
    Costa, D. J.
    European Innovat Partnership Act and Health Ageing Re, France; Montpellier University Hospital, France.
    Custovic, A.
    University of Manchester, England.
    Dahlen, S. E.
    Karolinska Institute, Sweden.
    Darsow, U.
    Technical University of Munich, Germany.
    De Carlo, G.
    EFA European Federat Allergy and Airways Disease Patien, Belgium.
    De Blay, F.
    University Hospital Strasbourg, France.
    Deleanu, D.
    European Regional and Local Health Assoc, Belgium; Iuliu Hatieganu University of Medical and Pharm, Romania.
    Denburg, J. A.
    McMaster University, Canada.
    Devillier, P.
    Suresnes University of Versailles St Quentin, France.
    Didier, A.
    Rangueil Larrey Hospital, France.
    Dinh-Xuan, A. T.
    University of Paris 05, France.
    Dokic, D.
    University of Skopje, Macedonia.
    Douagui, H.
    Centre Hospital University of Beni Messous, Algeria.
    Dray, G.
    Ecole Mines, France.
    Dubakiene, R.
    Vilnius State University, Lithuania.
    Durham, S. R.
    University of London Imperial Coll Science Technology and Med, England.
    Dykewicz, M. S.
    St Louis University, MI USA.
    El-Gamal, Y.
    Ain Shams University, Egypt.
    Emuzyte, R.
    Vilnius State University, Lithuania.
    Fink Wagner, A.
    Global Allergy and Asthma Platform GAAPP, Austria.
    Fletcher, M.
    Educ Heatlh, England.
    Fiocchi, A.
    Bambino Gesu Childrens Research Hospital Holy See, Italy.
    Forastiere, F.
    Regional Health Serv Lazio Reg, Italy.
    Gamkrelidze, A.
    National Centre Disease Control and Public Health Georgia, Rep of Georgia.
    Gemicioglu, B.
    Turkish Thorac Soc, Turkey.
    Gereda, J. E.
    Clin Ricardo Palma, Peru.
    Gonzalez Diaz, S.
    Sociedad Latinoamer Allergia Asma and Immunol, Mexico.
    Gotua, M.
    Georgian Assoc Allergol and Clin Immunol, Rep of Georgia.
    Grouse, L.
    University of Washington, WA USA.
    Guzman, M. A.
    University of Chile, Chile.
    Haahtela, T.
    Helsinki University Hospital, Finland.
    Hellquist-Dahl, B.
    Odense University Hospital, Denmark.
    Heinrich, J.
    Helmholtz Zentrum Munchen, Germany.
    Horak, F.
    Vienna Challenge Chamber, Austria.
    Hourihane, J. O. B.
    National University of Ireland University of Coll Cork, Ireland.
    Howarth, P.
    University of Southampton, England.
    Humbert, M.
    University of Paris 11, France; Hop Bicetre, France.
    Ivancevich, J. C.
    Clin Santa Isabel, Argentina.
    Jares, E. J.
    Libra Fdn, Argentina.
    Johnston, S. L.
    University of London Imperial Coll Science Technology and Med, England; MRC, England; Asthma UK Centre Allerg Mech Asthma, England.
    Joos, G.
    Ghent University Hospital, Belgium.
    Jonquet, O.
    Montpellier University Hospital, France.
    Jung, K. S.
    Hallym University, South Korea.
    Just, J.
    Hop Enfants Armand Trousseau, France; University of Paris 06, France.
    Kaidashev, I.
    Ukrainian Medical Stomatol Acad, Ukraine.
    Kalayci, O.
    Hacettepe University, Turkey.
    Kalyoncu, A. F.
    Hacettepe University, Turkey.
    Keil, T.
    Charite, Germany; University of Wurzburg, Germany.
    Keith, P. K.
    McMaster University, Canada.
    Khaltaev, N.
    GARD, Switzerland.
    Klimek, L.
    Centre Rhinol and Allergol, Germany.
    Koffi NGoran, B.
    Soc Pneumol Langue Francaise, France; Espace Francophone Pneumol, France.
    Kolek, V.
    University Hospital Olomouc, Czech Republic.
    Koppelman, G. H.
    University of Groningen, Netherlands.
    Kowalski, M. L.
    Medical University of Lodz, Poland.
    Kull, I.
    Sachs Childrens Hospital, Sweden; Karolinska Institute, Sweden.
    Kuna, P.
    Medical University of Lodz, Poland.
    Kvedariene, V.
    Vilnius State University, Lithuania.
    Lambrecht, B.
    University of Ghent, Belgium.
    Lau, S.
    Charite, Germany.
    Larenas-Linnemann, D.
    Hospital Medical Sur, Mexico.
    Laune, D.
    Digi Heatlh, France.
    Le, L. T. T.
    University of Medical and Pharm, Vietnam.
    Lieberman, P.
    University of Tennessee, TN USA; University of Tennessee, TN USA; University of Tennessee, TN USA.
    Lipworth, B.
    University of Dundee, Scotland.
    Li, J.
    Guangzhou Medical University, Peoples R China.
    Louis, R.
    CHU Sart Tilman, Belgium.
    Magard, Y.
    Hop St Joseph, France.
    Magnan, A.
    University of Nantes, France.
    Mahboub, B.
    Rashid Hospital, U Arab Emirates.
    Makela, M. J.
    Helsinki University Hospital, Finland.
    De Manuel Keenoy, E.
    Kronikgune, Spain.
    Marshall, G. D.
    University of Mississippi, MS 39216 USA.
    Masjedi, M. R.
    Shahid Beheshti University of Medical Science, Iran.
    Maurer, M.
    Charite, Germany; Charite, Germany.
    Mavale-Manuel, S.
    Maputo Central Hospital, Mozambique.
    Melen, E.
    Karolinska Institute, Sweden.
    Melo-Gomes, E.
    Fac Medical Lisbon, Portugal.
    Meltzer, E. O.
    Allergy and Asthma Medical Grp and Research Centre, CA USA.
    Merk, H.
    Rhein Westfal TH Aachen, Germany.
    Miculinic, N.
    Croatian Pulm Soc, Croatia.
    Mihaltan, F.
    National Institute Pneumol M Nasta, Romania.
    Milenkovic, B.
    University of Belgrade, Serbia; Serbian Assoc Asthma and COPD, Serbia.
    Mohammad, Y.
    Tishreen University, Syria.
    Molimard, M.
    University of Bordeaux, France.
    Momas, I.
    Paris Descartes University, France; Paris Municipal Department Social Act Childhood and Heatlh, France.
    Montilla-Santana, A.
    Aura Andalucia, Spain.
    Morais-Almeida, M.
    Hospital CUF Descobertas, Portugal.
    Moesges, R.
    University of Cologne, Germany.
    Namazova-Baranova, L.
    Russian Academic Medical Science, Russia.
    Naclerio, R.
    University of Chicago, IL 60637 USA; University of Chicago, IL 60637 USA.
    Neou, A.
    Charite, Germany.
    Neffen, H.
    Hospital Ninos Orlando Alassia, Argentina.
    Nekam, K.
    Hospital Hospitaller Bros Buda, Hungary.
    Niggemann, B.
    Charite, Germany.
    Nyembue, T. D.
    University Hospital Kinshasa, Zaire.
    OHehir, R. E.
    Monash University, Australia; Monash University, Australia.
    Ohta, K.
    Tokyo National Hospital, Japan.
    Okamoto, Y.
    Chiba University Hospital, Japan.
    Okubo, K.
    Nippon Medical Sch, Japan.
    Ouedraogo, S.
    Centre Hospital University of Pediat Charles Gaulle, Burkina Faso.
    Pali-Schoell, I.
    University of Vienna, Austria; University of Vet Medical Vienna, Austria; University of Vet Medical Vienna, Austria; University of Vienna, Austria.
    Palmer, S.
    University of York, England.
    Panzner, P.
    Charles University of Prague, Czech Republic; .
    Papi, A.
    University of Ferrara, Italy.
    Park, H. S.
    Ajou University, South Korea.
    Pavord, I.
    University of Oxford, England.
    Pawankar, R.
    Nippon Medical Sch, Japan.
    Pfaar, O.
    Centre Rhinol and Allergol, Germany; Heidelberg University, Germany.
    Picard, R.
    Conseil Gen Econ, France.
    Pigearias, B.
    Soc Pneumol Langue Francaise, France; Espace Francophone Pneumol, France.
    Pin, I.
    CHU Grenoble, France.
    Plavec, D.
    University Hospital Pisa, Italy; University of JJ Strossmayer, Croatia.
    Pohl, W.
    Hietzing Hospital, Austria.
    Popov, T. A.
    Medical University of Sofia, Bulgaria.
    Portejoie, F.
    European Innovat Partnership Act and Health Ageing Re, France.
    Postma, D.
    University of Groningen, Netherlands.
    Potter, P.
    University of Cape Town, South Africa.
    Price, D.
    University of Aberdeen, Scotland; Research Real Life, England.
    Rabe, K. F.
    LungenClin Grosshansdorf, Germany; University of Kiel, Germany.
    Raciborski, F.
    Medical University of Warsaw, Poland.
    Radier Pontal, F.
    Maison Profess Liberales, France.
    Repka-Ramirez, S.
    SLAAI, Mexico.
    Robalo-Cordeiro, C.
    Hospital University of Coimbra, Portugal.
    Rolland, C.
    Assoc Asthme and Allergie, France.
    Reitamo, S.
    Helsinki University Hospital, Finland.
    Roman Rodriguez, M.
    Institute Invest Sanitaria Palma IdisPa, Spain.
    Romano, A.
    Complesso Integrato Columbus, Italy.
    Rosario, N.
    University of Federal Parana, Brazil.
    Rosenwasser, L.
    University of Misouri, MI USA.
    Rottem, M.
    Emek Medical Centre, Israel.
    Sanchez-Borges, M.
    Centre Meddocente La, Venezuela; Clin El Avila, Venezuela.
    Scadding, G. K.
    UCL, England.
    Serrano, E.
    CHU Rangueil Larrey, France.
    Schmid-Grendelmeier, P.
    University of Zurich Hospital, Switzerland.
    Sheikh, A.
    University of Edinburgh, Scotland.
    Simons, F. E. R.
    University of Manitoba, Canada.
    Sisul, J. C.
    Soc Paraguaya Alergia Asma and Inmunol, Paraguay.
    Skrindo, I.
    Oslo University Hospital, Norway; University of Oslo, Norway.
    Smit, H. A.
    University of Utrecht, Netherlands.
    Sole, D.
    University of Federal Sao Paulo, Brazil.
    Sooronbaev, T.
    Euroasian Resp Soc, Kyrgyzstan.
    Spranger, O.
    Global Allergy and Asthma Platform GAAPP, Austria.
    Stelmach, R.
    University of Sao Paulo, Brazil.
    Strandberg, T.
    European Union Geriatr Medical Soc, Austria.
    Sunyer, J.
    Centre Research Environm Epidemiol, Spain; Hospital del Mar, Spain; CIBER Epidemiol and Salud Publ, Spain; University of Pompeu Fabra, Spain.
    Thijs, C.
    Maastricht University, Netherlands.
    Todo-Bom, A.
    University of Coimbra, Portugal.
    Triggiani, M.
    University of Salerno, Italy.
    Valenta, R.
    Medical University of Vienna, Austria.
    Valero, A. L.
    IDIBAPS, Spain.
    van Hage, M.
    Karolinska Institute, Sweden.
    Vandenplas, O.
    Catholic University of Louvain, Belgium.
    Vezzani, G.
    Research Hospital, Italy; Regional Agency Health and Social Care, Italy.
    Vichyanond, P.
    Mahidol University, Thailand.
    Viegi, G.
    CNR, Italy.
    Wagenmann, M.
    University of Klinikum Dusseldorf, Germany.
    Walker, S.
    Asthma UK, England.
    Wang, D. Y.
    National University of Singapore, Singapore.
    Wahn, U.
    Aura Andalucia, Jaen, Spain.
    Williams, D. M.
    University of N Carolina, NC USA.
    Wright, J.
    Bradford Royal Infirm, England.
    Yawn, B. P.
    Olmsted Medical Centre, MN USA.
    Yiallouros, P. K.
    Cyprus University of Technology, Cyprus; Hospital Archbishop Makarios III, Cyprus.
    Yusuf, O. M.
    Allergy and Asthma Institute, Pakistan.
    Zar, H. J.
    University of Cape Town, South Africa.
    Zernotti, M. E.
    University of Catolica Cordoba, Argentina.
    Zhang, L.
    Capital Medical University, Peoples R China.
    Zhong, N.
    Guangzhou Medical University, Peoples R China.
    Zidarn, M.
    University of Clin Resp and Allerg Disease, Slovenia.
    Chatzi, L,
    Mercier, J.
    University of Montpellier, France.
    Dedeu, T,
    Hyland, ME,
    Majer, I,
    Manning, P,
    Paggiaro, P,
    Rosado-Pinto, J,
    Rodenas, F,
    MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation2015Ingår i: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 70, nr 11, s. 1372-1392Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards.

  • 20.
    Nestor, Colm E
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
    Ottaviano, Raffaele
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
    Reinhardt, Diana
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
    Cruickshanks, Hazel A
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
    Mjoseng, Heidi K
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
    McPherson, Rhoanne C
    MRC Centre for Inflammation Research, Centre for Multiple Sclerosis Research and Centre for Immunity Infection and Evolution, University of Edinburgh, Edinburgh EH16 4TJ, UK.
    Lentini, Antonio
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Thomson, John P
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK .
    Dunican, Donncha S
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK .
    Pennings, Sari
    Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
    Anderton, Stephen M
    MRC Centre for Inflammation Research, Centre for Multiple Sclerosis Research and Centre for Immunity Infection and Evolution, University of Edinburgh, Edinburgh EH16 4TJ, UK.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Meehan, Richard R
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK .
    Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.2015Ingår i: Genome Biology, ISSN 1465-6906, E-ISSN 1474-760X, Vol. 16, s. 11-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BackgroundThe DNA methylation profile of mammalian cell lines differs from the primary tissue from which they were derived, exhibiting increasing divergence from the in vivo methylation profile with extended time in culture. Few studies have directly examined the initial epigenetic and transcriptional consequences of adaptation of primary mammalian cells to culture, and the potential mechanisms through which this epigenetic dysregulation occurs is unknown.ResultsWe demonstrate that adaptation of mouse embryonic fibroblast, MEFS, to cell culture results in a rapid reprogramming of epigenetic and transcriptional states. We observed global 5-hydroxymethylcytosine (5hmC) erasure within three days of culture initiation. Loss of genic 5hmC was independent of global 5-methylcytosine (5mC) levels and could be partially rescued by addition of Vitamin C. Significantly, 5hmC loss was not linked to concomitant changes in transcription. Discrete promoter-specific gains of 5mC were also observed within seven days of culture initiation. Against this background of global 5hmC loss we identified a handful of developmentally important genes that maintained their 5hmC profile in culture, including the imprinted loci Gnas and H19. Similar outcomes were identified in the adaption of CD4+ T-cells to culture.ConclusionsWe report a dramatic and novel consequence of adaptation of mammalian cells to culture in which global loss of 5hmC occurs; suggesting rapid concomitant loss of methylcytosine dioxygenase activity. The observed epigenetic and transcriptional re-programming occurs much earlier than previously assumed, and has significant implications for the use of cell lines as faithful mimics of in vivo epigenetic and physiological processes.

  • 21.
    Zhou, Yuan
    et al.
    Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China.
    Wang, Hui
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
    Wang, Cong
    Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China.
    Qiu, Xuefeng
    Nanjing University, Peoples R China.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Allergicentrum US.
    Yin, Xiaoqin
    Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China.
    Xiang, Zou
    University of Gothenburg, Sweden.
    Li, Dongmei
    Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China.
    Han, Xiaodong
    Nanjing University, Peoples R China; Nanjing University, Peoples R China; Nanjing University, Peoples R China.
    Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity2015Ingår i: Toxicology and Applied Pharmacology, ISSN 0041-008X, E-ISSN 1096-0333, Vol. 287, nr 1Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Microcystin (MC)-LR, a cyclic heptapeptide, is a potent reproductive system toxin. To understand the molecular mechanisms of MC-induced reproductive system cytotoxicity, we evaluated global changes of miRNA and mRNA expression in mouse Sertoli cells following MC-LR treatment. Our results revealed that the exposure to MC-LR resulted in an altered miRNA expression profile that might be responsible for the modulation of mRNA expression. Bio-functional analysis indicated that the altered genes were involved in specific cellular processes, including cell death and proliferation. Target gene analysis suggested that junction injury in Sertoli cells exposed to MC-LR might be mediated by miRNAs through the regulation of the Sertoli cell-Sertoli cell pathway. Collectively, these findings may enhance our understanding on the modes of action of MC-LR on mouse Sertoli cells as well as the molecular mechanisms underlying the toxicity of MC-LR on the male reproductive system.

  • 22.
    Bruhn, Sören
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Fang, Yu
    Guiyang Medical Coll, Peoples R China University of Gothenburg, Sweden .
    Barrenäs, Fredrik
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Gustafsson, Mika
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Konstantinell, Aelita
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Kronke, Andrea
    Cenix BioScience GmbH, Germany .
    Sonnichsen, Birte
    Cenix BioScience GmbH, Germany .
    Bresnick, Anne
    Albert Einstein Coll Med, NY 10461 USA .
    Dulyaninova, Natalya
    Albert Einstein Coll Med, NY 10461 USA .
    Wang, Hui
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Zhao, Yelin
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Klingelhofer, Jorg
    University of Copenhagen, Denmark .
    Ambartsumian, Noona
    University of Copenhagen, Denmark .
    Beck, Mette K.
    Technical University of Denmark, Denmark .
    Nestor, Colm
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Bona, Elsa
    Boras Hospital, Sweden .
    Xiang, Zou
    University of Gothenburg, Sweden .
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Allergicentrum US. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
    A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy2014Ingår i: Science Translational Medicine, ISSN 1946-6234, E-ISSN 1946-6242, Vol. 6, nr 218Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The identification of diagnostic markers and therapeutic candidate genes in common diseases is complicated by the involvement of thousands of genes. We hypothesized that genes co-regulated with a key gene in allergy, IL13, would form a module that could help to identify candidate genes. We identified a T helper 2 (T(H)2) cell module by small interfering RNA-mediated knockdown of 25 putative IL13-regulating transcription factors followed by expression profiling. The module contained candidate genes whose diagnostic potential was supported by clinical studies. Functional studies of human TH2 cells as well as mouse models of allergy showed that deletion of one of the genes, S100A4, resulted in decreased signs of allergy including TH2 cell activation, humoral immunity, and infiltration of effector cells. Specifically, dendritic cells required S100A4 for activating T cells. Treatment with an anti-S100A4 antibody resulted in decreased signs of allergy in the mouse model as well as in allergen-challenged T cells from allergic patients. This strategy, which may be generally applicable to complex diseases, identified and validated an important diagnostic and therapeutic candidate gene in allergy.

  • 23.
    Wang, Kai
    et al.
    University of Tennessee, Knoxville, USA.
    Phillips, Charles A
    University of Tennessee, Knoxville, USA.
    Rogers, Gary L
    National Institute for Computational Sciences, Oak Ridge, Tennessee, USA.
    Barrenäs, Fredrik
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Hälsouniversitetet.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Allergicentrum US. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
    Langston, Michael A
    University of Tennessee, Knoxville, USA.
    Differential Shannon entropy and differential coefficient of variation: alternatives and augmentations to differential expression in the search for disease-related genes2014Ingår i: International journal of computational biology and drug design, ISSN 1756-0756, Vol. 7, nr 2-3, s. 183-94Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Differential expression has been a standard tool for analysing case-control transcriptomic data since the advent of microarray technology. It has proved invaluable in characterising the molecular mechanisms of disease. Nevertheless, the expression profile of a gene across samples can be perturbed in ways that leave the expression level unaltered, while a biological effect is nonetheless present. This paper describes and analyses differential Shannon entropy and differential coefficient of variation, two alternate techniques for identifying genes of interest. Ontological analysis across 16 human disease datasets demonstrates that these alternatives are effective at identifying disease-related genes not found by mere differential expression alone. Because the two alternate techniques are based on somewhat different mathematical formulations, they tend to produce somewhat different gene lists. Moreover, each may pinpoint genes completely overlooked by the other. Thus, measures of entropy and variation can be used to replace or better yet augment standard differential expression computations.

  • 24.
    Nestor, Colm
    et al.
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Barrenäs, Fredrik
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Wang, Hui
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Lentini, Antonio
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Zhang, Huan
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Bruhn, Sören
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Jornsten, Rebecka
    University of Gothenburg, Sweden .
    Langston, Michael A.
    University of Tennessee, TN USA .
    Rogers, Gary
    University of Tennessee, TN USA .
    Gustafsson, Mika
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Allergicentrum US. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
    DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4(+) T-Cell Population Structure2014Ingår i: PLoS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 10, nr 1, s. e1004059-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Altered DNA methylation patterns in CD4(+) T-cells indicate the importance of epigenetic mechanisms in inflammatory diseases. However, the identification of these alterations is complicated by the heterogeneity of most inflammatory diseases. Seasonal allergic rhinitis (SAR) is an optimal disease model for the study of DNA methylation because of its welldefined phenotype and etiology. We generated genome-wide DNA methylation (N-patients = 8, N-controls = 8) and gene expression (N-patients = 9, N-controls = 10) profiles of CD4(+) T-cells from SAR patients and healthy controls using Illuminas HumanMethylation450 and HT-12 microarrays, respectively. DNA methylation profiles clearly and robustly distinguished SAR patients from controls, during and outside the pollen season. In agreement with previously published studies, gene expression profiles of the same samples failed to separate patients and controls. Separation by methylation (N-patients = 12, N-controls = 12), but not by gene expression (N-patients = 21, N-controls = 21) was also observed in an in vitro model system in which purified PBMCs from patients and healthy controls were challenged with allergen. We observed changes in the proportions of memory T-cell populations between patients (N-patients = 35) and controls (N-controls = 12), which could explain the observed difference in DNA methylation. Our data highlight the potential of epigenomics in the stratification of immune disease and represents the first successful molecular classification of SAR using CD4(+) T cells.

  • 25.
    Schoenrock, Andrew
    et al.
    Carleton University, Ottawa, Canada.
    Samanfar, Bahram
    Carleton University, Ottawa, Canada.
    Pitre, Sylvain
    Carleton University, Ottawa, Canada.
    Hooshyar, Mohsen
    Carleton University, Ottawa, Canada.
    Jin, Ke
    University of Toronto, Toronto, Canada.
    Phillips, Charles A
    University of Tennessee, Knoxville, Tennessee, USA.
    Wang, Hui
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Gothenburg University, Gothenburg, Sweden.
    Phanse, Sadhna
    University of Toronto, Toronto, Canada.
    Omidi, Katayoun
    University of Toronto, Toronto, Canada.
    Gui, Yuan
    University of Toronto, Toronto, Canada.
    Alamgir, Md
    University of Toronto, Toronto, Canada.
    Wong, Alex
    University of Toronto, Toronto, Canada.
    Barrenäs, Fredrik
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Gothenburg University, Gothenburg, Sweden.
    Babu, Mohan
    University of Regina, Regina, Saskatchewan, Canada.
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Allergicentrum US. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping. Gothenburg University, Gothenburg, Sweden.
    Langston, Michael A
    Carleton University, Ottawa, Canada.
    Green, James R
    Carleton University, Ottawa, Canada.
    Dehne, Frank
    Carleton University, Ottawa, Canada.
    Golshani, Ashkan
    Carleton University, Ottawa, Canada.
    Efficient prediction of human protein-protein interactions at a global scale2014Ingår i: BMC bioinformatics, ISSN 1471-2105, Vol. 15, nr 1, s. 383-Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BackgroundOur knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods.ResultsOn the basis of short co-occurring polypeptide regions, we developed a tool called MP-PIPE capable of predicting a global human PPI network within 3 months. With a recall of 23% at a precision of 82.1%, we predicted 172,132 putative PPIs. We demonstrate the usefulness of these predictions through a range of experiments.ConclusionsThe speed and accuracy associated with MP-PIPE can make this a potential tool to study individual human PPI networks (from genomic sequences alone) for personalized medicine.

  • 26.
    Bousquet, J.
    et al.
    University Hospital Montpellier, France MACVIA LR, France ARIA, France European Academic Allergy and Clin Immunol, France European Innovat Partnership Act and Health Ageing, France European Innovat Partnership Act and Health Ageing, France University of Montpellier I, France .
    Addis, A.
    European Innovat Partnership Act and Health Ageing, France European Innovat Partnership Act and Health Ageing, Italy .
    Adcock, I.
    University of London Imperial Coll Science Technology and Med, England Royal Brompton and Harefield NIHR Biomed Research Unit, England .
    Agache, I.
    ARIA, France Romanian Alliance Chron Resp Disease, Romania Transylvania University, Romania .
    Agusti, A.
    University of Barcelona, Spain CIBER Enfermedades Resp, Spain .
    Alonso, A.
    Hospital Clin Barcelona, Spain .
    Annesi-Maesano, I.
    ARIA, France .
    M. Anto, J.
    University of Pompeu Fabra, Spain .
    Bachert, C.
    ARIA, France Ghent University Hospital, Belgium Ghent University Hospital, Belgium .
    E. Baena-Cagnani, C.
    ARIA, France Catholic University, Argentina .
    Bai, C.
    Chinese Medical Assoc, Peoples R China .
    Baigenzhin, A.
    EuroAsian Resp Soc, Kazakhstan .
    Barbara, C.
    European Innovat Partnership Act and Health Ageing, France Portuguese National Programme Resp Disease, Portugal .
    Barnes, P.J.
    University of London Imperial Coll Science Technology and Med, England Royal Brompton and Harefield NIHR Biomed Research Unit, England .
    Bateman, E.D.
    ARIA, France University of Cape Town, South Africa .
    Beck, L.
    Health Innovat Centre Southern Denmark, Denmark .
    Bedbrook, A.
    MACVIA LR, France ARIA, France .
    Bel, E.H.
    University of Amsterdam, Netherlands .
    Benezet, O.
    MACVIA LR, France .
    Bennoor, K.S.
    ARIA, France Bangladesh Lung Fdn, Bangladesh National Institute Disease Chest and Hospital, Bangladesh .
    Benson, Mikael
    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Allergicentrum US. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
    Bernabeu-Wittel, M.
    European Innovat Partnership Act and Hlthy Ageing, Spain Andalusian Healthcare Serv, Spain .
    Bewick, M.
    NHS England, England .
    Bindslev-Jensen, C.
    ARIA, France Odense University Hospital, Denmark Odense University Hospital, Denmark .
    Blain, H.
    University Hospital Montpellier, France MACVIA LR, France University of Montpellier I, France .
    Blasi, F.
    University of Milan, Italy .
    Bonini, M.
    ARIA, France University of Roma La Sapienza, Italy .
    Bonini, S.
    ARIA, France University of Naples 2, Italy Italian National Research Council, Italy .
    Boulet, L.P.
    ARIA, France University of Laval, Canada .
    Bourdin, A.
    University Hospital Montpellier, France MACVIA LR, France University of Montpellier I, France INSERM, France .
    Bourret, R.
    University Hospital Montpellier, France MACVIA LR, France .
    Bousquet, P.J.
    ARIA, France .
    Brightling, C.E.
    Glenfield Hospital, England .
    Briggs, A.
    University of Glasgow, Scotland .
    Brozek, J.
    ARIA, France McMaster University, Canada McMaster University, Canada .
    Buh, R.
    Mainz University Hospital, Germany .
    Bush, A.
    ARIA, France University of London Imperial Coll Science Technology and Med, England University of London Imperial Coll Science Technology and Med, England .
    Caimmi, D.
    University Hospital Montpellier, France MACVIA LR, France .
    Calderon, M.
    University of Costa Rica, Costa Rica University of London Imperial Coll Science Technology and Med, England .
    Calverley, P.
    University of Liverpool, England Aintree University Hospital NHS Fdn Trust, England .
    Camargos, P.A.
    ARIA, France University of Federal Minas Gerais, Brazil .
    Camuzat, T.
    MACVIA LR, France .
    Canonica, G.W.
    ARIA, France University of Genoa, Italy .
    Carlsen, K.H.
    ARIA, France University of Oslo, Norway Oslo University Hospital, Norway .
    Casale, T.B.
    ARIA, France .
    Cazzola, M.
    University of Roma Tor Vergata, Italy .
    Cepeda Sarabia, A.M.
    ARIA, France University of Simon Bolivar, Colombia Soc Latinoamer Allergia Asma and Immunol, Italy .
    Cesario, A.
    IRCCS San Raffaele Pisana, Italy .
    Chen, Y.Z.
    Peking and Centre Asthma Research and Educ, Peoples R China .
    Chkhartishvili, E.
    Grigol Robakidze University, Rep of Georgia .
    Chavannes, N.
    ARIA, France Int Primary Care Resp Grp, Netherlands Leiden University, Netherlands .
    Chiron, R.
    University Hospital Montpellier, France MACVIA LR, France .
    Chuchalin, A.
    ARIA, France WHO, Russia Pulmonol Research Institute, Russia Russian Resp Soc, Russia .
    Chung, K.F.
    University of London Imperial Coll Science Technology and Med, England Royal Brompton and Harefield NIHR Biomed Research Unit, England .
    Cox, L.
    ARIA, France Nova SE University, FL USA .
    Crooks, G.
    NHS Scotland, Scotland .
    G. Crooks, M.
    Hull York Medical Sch, England .
    A. Cruz, A.
    ARIA, France WHO, Russia University of Federal Bahia, Brazil CNPq, Brazil .
    Custovic, A.
    ARIA, France European Academic Allergy and Clin Immunol, France University of Manchester, England .
    Dahl, R.
    ARIA, France Odense University Hospital, Denmark Odense University Hospital, Denmark .
    E. Dahlen, S.
    Karolinska Institute, Sweden .
    De Blay, F.
    ARIA, France Soc Francaise Allergol, France Strasbourg University, France .
    Dedeu, T.
    European Regional and Health Author, Belgium .
    Deleanu, D.
    ARIA, France University of Medical and Pharm Iuliu Hatieganu, Romania .
    Demoly, P.
    University Hospital Montpellier, France MACVIA LR, France ARIA, France European Academic Allergy and Clin Immunol, France European Innovat Partnership Act and Health Ageing, France University of Montpellier I, France .
    Devillier, P.
    ARIA, France University of Versailles St Quentin, France .
    Didier, A.
    Soc Pneumol Langue Francaise, France University of Toulouse, France .
    T. Dinh-Xuan, A.
    Paris Descartes University, France .
    Djukanovic, R.
    University of Southampton, England NIHR, England .
    Dokic, D.
    ARIA, France University of Ss Cyril and Methodius, Macedonia .
    Douagui, H.
    ARIA, France Centre Hospital University of Beni Messous, Algeria .
    Dubakiene, R.
    ARIA, France Lithuanian Soc Allergol and Clin Immunol, Lithuania Vilnius State University, Lithuania .
    Eglin, S.
    University of Liverpool, England .
    Elliot, F.
    NHS Scotland, Scotland .
    Emuzyte, R.
    ARIA, France Lithuanian Soc Allergol and Clin Immunol, Lithuania Vilnius State University, Lithuania .
    Fabbri, L.
    University of Modena and Reggio Emilia, Italy .
    Fink Wagner, A.
    Global Allergy and Asthma Patient Platform, Austria .
    Fletcher, M.
    WHO, Russia Educ Heatlh, England .
    Fokkens, W.J.
    ARIA, France University of Amsterdam, Netherlands European Rhinol Soc, Portugal .
    Fonseca, J.
    ARIA, France Portuguese National Programme Resp Disease, Portugal Porto Age Up Consortium, Portugal University of Porto, Portugal University of Porto, Portugal Institute and Hospital CUF Porto, Portugal .
    Franco, A.
    University of Nice Sophia Antipolis, France .
    Frith, P.
    Repatriat Gen Hospital, Australia .
    Furber, A.
    Wakefield Council, England .
    Gaga, M.
    Athens Chest Hospital, Greece Athens Chest Hospital, Greece .
    Garces, J.
    European Innovat Partnership Act and Health Ageing, Spain University of Valencia, Spain .
    Garcia-Aymerich, J.
    University of Pompeu Fabra, Spain .
    Gamkrelidze, A.
    ARIA, France National Centre Disease Control and Public Health Georgia, Rep of Georgia .
    Gonzales-Diaz, S.
    ARIA, France Soc Latinoamer Allergia Asma and Immunol, Italy .
    Gouzi, F.
    University Hospital Montpellier, France INSERM, France .
    A. Guzman, M.
    ARIA, France University of Chile, Chile .
    Haahtela, T.
    ARIA, France Helsinki University Hospital, Finland .
    Harrison, D.
    Public Health Blackburn Darwen, England .
    Hayot, M.
    University Hospital Montpellier, France MACVIA LR, France University of Montpellier I, France .
    G. Heaney, L.
    Queens University of Belfast, North Ireland .
    Heinrich, J.
    MeDALL, Mechanisms of the Development of Allergy.
    Hellings, P. W.
    ARIA, France European Academic Allergy and Clin Immunol, France University Hospital Leuven, Belgium .
    Hooper, J.
    Public Health Kirklees, England .
    Humbert, M.
    Soc Pneumol Langue Francaise, France .
    Hyland, M.
    University of Plymouth, England .
    Iaccarino, G.
    University of Salerno, Italy IRCCS Multimed, Italy .
    Jakovenko, D.
    MACVIA LR, France .
    R. Jardim, J.
    University of Federal Sao Paulo, Brazil .
    Jeandel, C.
    University Hospital Montpellier, France MACVIA LR, France University of Montpellier I, France .
    Jenkins, C.
    George Institute Global Heatlh, Australia University of Sydney, Australia .
    L. Johnston, S.
    ARIA, France University of London Imperial Coll Science Technology and Med, England .
    Jonquet, O.
    University Hospital Montpellier, France MACVIA LR, France University of Montpellier I, France .
    Joos, G.
    Ghent University Hospital, Belgium .
    S. Jung, K.
    Hallym University, South Korea .
    Kalayci, O.
    ARIA, France European Academic Allergy and Clin Immunol, France Hacettepe University, Turkey .
    Karunanithi, S.
    Director of Public Health, Lancashire, UK.
    Keil, T.
    Charite, Germany University of Wurzburg, Germany .
    Khaltaev, N.
    ARIA, France WHO, Russia .
    Kolek, V.
    Czech Alliance Against Chron Resp Disease, Poland .
    L. Kowalski, M.
    Medical University of Lodz, Poland .
    Kull, I.
    Karolinska Institute, Sweden .
    Kuna, P.
    ARIA, France European Innovat Partnership Act and Health Ageing, France WHO, Russia Medical University of Lodz, Poland .
    Kvedariene, V.
    ARIA, France European Academic Allergy and Clin Immunol, France Lithuanian Soc Allergol and Clin Immunol, Lithuania Vilnius State University, Lithuania .
    T. Le, L.
    ARIA, France WHO, Russia University of Medical and Pharm, Vietnam .
    C. Lodrup Carlsen, K.
    ARIA, France University of Oslo, Norway Oslo University Hospital, Norway .
    Louis, R.
    University of Liege, Belgium .
    MacNee, W.
    University of Edinburgh, Scotland .
    Mair, A.
    Scottish Govt, Scotland .
    Majer, I.
    University of Bratislava, Slovakia .
    Manning, P.
    Bon Secours Hospital, Ireland .
    de Manuel Keenoy, E.
    European Innovat Partnership Act and Health Ageing, France Kronikgune, Spain .
    R. Masjedi, M.
    Shahid Beheshti University of Medical Science, Iran .
    Meten, E.
    ARIA, France Karolinska Institute, Sweden .
    Melo-Gomes, E.
    European Innovat Partnership Act and Health Ageing, France Portuguese National Programme Resp Disease, Portugal .
    Menzies-Gow, A.
    Royal Brompton Hospital, England .
    Mercier, G.
    University Hospital Montpellier, France MACVIA LR, France University of Montpellier I, France .
    Mercier, J.
    University Hospital Montpellier, France MACVIA LR, France European Innovat Partnership Act and Health Ageing, France University of Montpellier I, France .
    P. Michel, J.
    Geneva School Med, Switzerland University Hospital Geneva, Switzerland .
    Miculinic, N.
    University Hospital Pulm Disease, Croatia .
    Mihaltan, F.
    ARIA, France Institute Pneumol Marius Nasta, Romania .
    Milenkovic, B.
    University of Belgrade, Serbia COPD Serbia, Serbia .
    Molimard, M.
    Bordeaux University, France .
    Mamas, I.
    Paris Descartes University, France Paris Municipal, France .
    Montilla-Santana, A.
    European Innovat Partnership Act and Hlthy Ageing, Spain .
    Morais-Almeida, M.
    Hospital CUF Descobertas, Portugal .
    Morgan, M.
    NHS England, England .
    NDiaye, M.
    Hop Polyclin Dakar IHS, Senegal .
    Nafti, S.
    ARIA, France Mustapha Hospital, Algeria .
    Nekam, K.
    ARIA, France Hospital Hospital Bros Buda, Hungary .
    Neou, A.
    Charite, Germany .
    Nicod, L.
    CHUV Lausanne, Switzerland .
    OHehir, R.
    ARIA, France Alfred Hospital, Australia Monash University, Australia .
    Ohta, K.
    ARIA, France Tokyo National Hospital, Japan Teikyo University, Japan .
    Paggiaro, P.
    University Hospital Pisa, Italy .
    Palkonen, S.
    ARIA, France .
    Palmer, S.
    University of York, England .
    Papadopoulos, N. G.
    ARIA, France European Academic Allergy and Clin Immunol, France University of Manchester, England University of Athens, Greece .
    Papi, A.
    University of Ferrara, Italy .
    Passalacqua, G.
    ARIA, France University of Genoa, Italy .
    Pavord, I.
    University of Oxford, England .
    Pigearias, B.
    SPLF, Espace francophone de Pneumologie.
    Plavec, D.
    University of JJ Strossmayer, Croatia .
    Postma, D. S.
    University of Groningen, Netherlands .
    Price, D.
    ARIA, France Int Primary Care Resp Grp, Netherlands University of Aberdeen, Scotland .
    Rabe, K. F.
    University of Kiel, Germany .
    Radier Pontal, F.
    MACVIA LR, France .
    Redon, J.
    European Innovat Partnership Act and Health Ageing, France University of Valencia, Spain .
    Rennard, S.
    University of Nebraska Medical Centre, NE USA .
    Roberts, J.
    Salford Royal NHS Fdn Trust, England .
    Robine, J. M.
    MACVIA LR, France INSERM, France .
    Roca, J.
    University of Barcelona, Spain CIBER Enfermedades Resp, Spain .
    Roche, N.
    University of Paris 05, France Soc Pneumol Langue Francaise, France .
    Rodenas, F.
    European Innovat Partnership Act and Health Ageing, Spain University of Valencia, Spain .
    Roggeri, A.
    Arcispedale S Maria Nuova Hospital, Italy .
    Rolland, C.
    Assoc Asthme and Allergies, France .
    Rosado-Pinto, J.
    ARIA, France European Innovat Partnership Act and Health Ageing, France Portuguese National Programme Resp Disease, Portugal WHO, Russia .
    Ryan, D.
    ARIA, France Int Primary Care Resp Grp, Netherlands Woodbrook Medical Centre, England University of Edinburgh, Scotland .
    Samolinski, B.
    European Innovat Partnership Act and Health Ageing, France Medical University of Lodz, Poland Medical University of Warsaw, Poland .
    Sanchez-Borges, M.
    Centre Medical Docente La Trinidad, Venezuela .
    Schunemann, H. J.
    McMaster University, Canada McMaster University, Canada .
    Sheikh, A.
    University of Edinburgh, Scotland Harvard University, MA 02115 USA .
    Shields, M.
    Queens University of Belfast, North Ireland Royal Belfast Hospital Sick Children, North Ireland .
    Siafakas, N.
    University Hospital Heraklion, Greece .
    Sibille, Y.
    Catholic University of Louvain, Belgium .
    Similowski, T.
    University of Paris 06, France INSERM, France Grp Hospital Pitie Salpetriere Charles Foix, France Fonds Dotat Rech Sante Resp Fdn Souffle, France .
    Small, I.
    National Advisory Group, Respiratory Managed Clinical Networks in Scotland.
    Sola-Morales, O.
    Health Institute Technology Transfer, Spain .
    Sooronbaev, T.
    ARIA, France WHO, Russia EuroAsian Resp Soc, Kyrgyzstan National Centre Cardiol and Internal Med, Kyrgyzstan .
    Stelmach, R.
    University of Sao Paulo, Brazil .
    Sterk, P. J.
    University of Amsterdam, Netherlands .
    Stiris, T.
    University of Oslo, Norway .
    Sud, P.
    Regional Medical Manager (North), NHS England, UK.
    Tellier, V.
    Observatoire wallon de la santé, Direction générale opérationnelle Pouvoirs locaux, action sociale et Santé, Service public de Wallonie, Belgium .
    To, T.
    WHO, Russia .
    Todo-Bom, A.
    Coimbra University Hospital, Portugal .
    Triggiani, M.
    University of Salerno, Italy .
    Valenta, R.
    ARIA, France Medical University of Vienna, Austria .
    Valero, A. L.
    University of Barcelona, Spain CIBER Enfermedades Resp, Spain .
    Valiulis, A.
    ARIA, France Lithuanian Soc Allergol and Clin Immunol, Lithuania Vilnius State University, Lithuania .
    Valovirta, E.
    University of Turku, Finland .
    Van Ganse, E.
    CHU Lyon, France CHU Lyon, France University of Lyon 1, France .
    Vandenplas, O.
    ARIA, France INSERM, France .
    Vasankari, T.
    FILHA, Finnish Lung Association.
    Vestbo, J.
    University of Manchester, England Odense University Hospital, Denmark .
    Vezzani, G.
    Arcispedale S Maria Nuova IRCCS, Italy .
    Viegi, G.
    CNR, Italy CNR, Italy Clin Physiol IFC, Italy .
    Visier, L.
    University Hospital Montpellier, France MACVIA LR, France University of Montpellier I, France .
    Vogelmeier, C.
    University of Marburg, Germany .
    Vontetsianos, T.
    Sotiria Hospital, Greece .
    Wagstaff, R.
    Cumbria County Council, PA USA .
    Wahn, U.
    Charite, Germany .
    Wallaert, B.
    Soc Francaise Allergol, France CHRU, France .
    Whalley, B.
    University of Plymouth, England .
    Wickman, M.
    ARIA, France Karolinska Institute, Sweden .
    M. Williams, D.
    University of N Carolina, NC USA .
    Wilson, N.
    North England EU Health Partnership, Belgium .
    Yawn, B. P.
    ARIA, France Olmsted Medical Centre, MN USA University of Minnesota, MN USA .
    Yiallouros, P.K.
    ARIA, France Cyprus University of Technology, Cyprus .
    Yorgancioglu, A.
    ARIA, France .
    Yusuf, O. M.
    WHO, Russia Allergy and Asthma Institute, Pakistan .
    Zar, H. J.
    University of Cape Town, South Africa .
    Zhong, N.
    Guangzhou Medical University, Peoples R China Guangzhou Medical University, Peoples R China .
    Zidarn, M.
    ARIA, France University of Clin Resp and Allerg Disease, Slovenia .
    Zuberbier, T.
    Charite, Germany .
    Integrated care pathways for airway diseases (AIRWAYS-ICPs)2014Ingår i: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 44, nr 2, s. 304-323Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiatives; 2) informing cost-effective policy development, strengthening in particular those on smoking and environmental exposure; 3) aiding risk stratification in chronic disease patients, using a common strategy; 4) having a significant impact on the health of citizens in the short term (reduction of morbidity, improvement of education in children and of work in adults) and in the long-term (healthy ageing); 5) proposing a common simulation tool to assist physicians; and 6) ultimately reducing the healthcare burden (emergency visits, avoidable hospitalisations, disability and costs) while improving quality of life. In the longer term, the incidence of disease may be reduced by innovative prevention strategies. AIRWAYS-ICPs was initiated by Area 5 of the Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing. All stakeholders are involved (health and social care, patients, and policy makers).

  • 27.
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    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
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    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
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    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
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    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
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    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet.
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    Karolinska Institute, Sweden Centre Molecular Med, Sweden .
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    Karolinska Institute, Sweden Centre Molecular Med, Sweden .
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    Karolinska Institute, Sweden Centre Molecular Med, Sweden .
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    IDIBELL, Spain .
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    Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk immunologi o