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  • 1.
    Andersen, Ken
    et al.
    European Spallation Source ESS AB, Lund, Sweden.
    Bigault, Thierry
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Birch, Jens
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Buffet, J. C.
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Correa, Jonathan
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Hall-Wilton, Richard
    European Spallation Source ESS AB, Lund, Sweden.
    Hultman, Lars
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Höglund, Carina
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Guerard, Bruno
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Jensen, Jens
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Khaplanov, Anton
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Kirstein, Oliver
    Linköping University.
    Piscitelli, Fransesco
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    van Esch, P.
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Vettier, Christian
    European Spallation Source, Lund, Sweden.
    10B multi-grid proportional gas counters for large area thermal neutrondetectors2013In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, Vol. 720, 116-121 p.Article in journal (Refereed)
    Abstract [en]

    3He was a popular material in neutrons detectors until its availability dropped drastically in 2008. The development of techniques based on alternative convertors is now of high priority for neutron research institutes. Thin films of 10B or 10B4C have been used in gas proportional counters to detect neutrons, but until now, only for small or medium sensitive area. We present here the multi-grid design, introduced at the ILL and developed in collaboration with ESS for LAN (large area neutron) detectors. Typically thirty 10B4C films of 1 μm thickness are used to convert neutrons into ionizing particles which are subsequently detected in a proportional gas counter. The principle and the fabrication of the multi-grid are described and some preliminary results obtained with a prototype of 200 cm×8 cm are reported; a detection efficiency of 48% has been measured at 2.5 Å with a monochromatic neutron beam line, showing the good potential of this new technique.

  • 2.
    Li, Jia
    Linköping University, Department of Electrical Engineering.
    10G GPON Management System Study and Implementation2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis includes the GPON management system concept study and implementation work to translate the command line interface management mechanism to a user friendly GUI (graphic user interface). The original system was developed in C program with a client-server structure. The new system retains the same communication structure and protocol interface between the OLT PON card and user workstations. On the workstation side, a new GUI management client application is developed in Java to offer the similar functionalities as the original one, and a totally new graphic real-time system traffic statistics function is integrated to make it easier for user to monitor system traffic information in real time.

     

    The main object of this project is to study the GPON specifications, and understand GPON system working procedure and traffic transmission principle. On the other hand, ‘original system management application’ study is necessary including third party documentation reading and C code understanding. This study has resulted in the development of a new application in Java with third party user libraries and plug-ins. This new application has been tested using basic function tests executed in the GPON lab environment.

  • 3.
    Dahlgaard Park, Su Mi
    et al.
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Management and Economics, Business Administration.
    Dahlgaard, Jens Jörn
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Engineering, Quality Technology and Management .
    10th QMOD Conference. Quality Management and Organizationel Development. Our Dreams of Excellence2008Report (Other academic)
  • 4.
    Jansson , Agneta
    Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences.
    17Beta-hydroxysteroid dehydrogenase enzymes and breast cancer2009In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ISSN 0960-0760 , Vol. 114, no 1-2, 64-67 p.Article in journal (Refereed)
    Abstract [en]

    Sex steroids play an important role in the development and differentiation in several tissues. Biologically active hormones that are locally converted in endocrine organs in the tissue where they exert their effects without release into extracellular space is a field of endocrinology that has been called intracrinology. In pre-menopausal women the ovary is the main source of estrogens, but in post-menopausal women the estrogen production as main site of synthesis moves to peripheral tissues and almost all of the sex steroids are synthesised from precursors of adrenal origin. In breast cancer 60-80% of the tumors express high levels of oestrogen receptor (ER) alpha which gives estrogen a proliferative effect. Breast tumors tend to have a higher intratumoral estrogen concentration than normal breast tissue and plasma, and in situ synthesis and the metabolism of estrogens is believed to be of great importance for the development and progression of the disease. The activity of estrogen metabolizing enzymes in breast are mainly aromatase, estrone sulfatases and 17HSD enzymes. 17HSD1 and 17HSD2 are the family members known to be of main importance in breast cancer. High expression of 17HSD1 has been associated to poor prognosis in breast cancer and late relapse among patients with ER-positive tumors. One of the mechanisms behind high 17HSD1 expression is gene amplification. Low or absent expression of 17HSD2 is associated to decreased survival in ER-positive breast cancer. 17HSD14 is one of the latest discovered 17HSD enzymes, transfection of 17HSD14 in human breast cancer cells significantly decreased the levels of estradiol in the culture medium. Low expression of 17HSD14 mRNA expression in breast cancer was correlated to decreased survival.

    The understanding of intratumoral synthesis of sex steroids in breast cancer is crucial to understand the disease both in pre- and post-menopausal women. Further studies are desirable to state the direct role of these enzymes in breast cancer and which patients that may benefit from new therapeutic strategies targeting 17HSD enzymes. The new inhibitors targeting 17HSD1 have shown promising results in preclinical studies to have clinical potential in the future.

  • 5.
    Jantunen, Liisa
    et al.
    Environment Canada, Canada.
    Wong, Fiona
    Stockholm University.
    Gawor, Anya
    Environment Canada.
    Kylin, Henrik
    Linköping University, The Tema Institute, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences.
    Helm, Paul
    Ontario Ministry of the Environment, Canada.
    Stern, Gary
    University of Manitoba, Canada.
    Strachan, William
    Environment Canada, Canada.
    Burniston, Deborah
    Environment Canada, Canada.
    Bidleman, Terry
    Umeå University.
    20 Years of Air-Water Gas Exchange Observations for Pesticides in the Western Arctic Ocean2015In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 49, no 23, 13844-13852 p.Article in journal (Refereed)
    Abstract [en]

    The Arctic has been contaminated by legacy organochlorine pesticides (OCPs) and currently used pesticides (CUPs) through atmospheric transport and oceanic currents. Here we report the time trends and air−water exchange of OCPs and CUPs from research expeditions conducted between 1993 and 2013. Compounds determined in both air and water were trans- and cis-chlordanes (TC, CC), trans- and cis-nonachlors (TN, CN), heptachlor exo-epoxide (HEPX), dieldrin (DIEL), chlorobornanes (ΣCHBs and toxaphene), dacthal (DAC), endosulfans and metabolite endosulfan sulfate (ENDO-I, ENDO-II, and ENDO SUL), chlorothalonil (CHT), chlorpyrifos (CPF), and trifluralin (TFN). Pentachloronitrobenzene (PCNB and quintozene) and its soil metabolite pentachlorothianisole (PCTA) were also found in air. Concentrations of most OCPs declined in surface water, whereas some CUPs increased (ENDO-I, CHT, and TFN) or showed no significant change (CPF and DAC), and most compounds declined in air. Chlordane compound fractions TC/(TC + CC) and TC/(TC + CC + TN) decreased in water and air, while CC/(TC + CC + TN) increased. TN/(TC + CC + TN) also increased in air and slightly, but not significantly, in water. These changes suggest selective removal of more labile TC and/or a shift in chlordane sources. Water−air fugacity ratios indicated net volatilization (FR > 1.0) or near equilibrium (FR not significantly different from 1.0) for most OCPs but net deposition (FR < 1.0) for ΣCHBs. Net deposition was shown for ENDO-I on all expeditions, while the net exchange direction of other CUPs varied. Understanding the processes and current state of air−surface exchange helps to interpret environmental exposure and evaluate the effectiveness of international protocols and provides insights for the environmental fate of new and emerging chemicals.

  • 6.
    Horner, Patrick J
    et al.
    School of Social and Community Medicine, University of Bristol, UK.
    Karla, Blee
    Bristol Sexual Health Centre, University Hospitals Bristol NHS Foundation Trust, UK.
    Falk, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in West Östergötland, Research & Development Unit in Local Health Care.
    van der Meijden, W
    Department of Dermatology, New Cross Hospital, UK..
    Moi, H.
    Olafia Clinic, Oslo University Hospital, Institute of Medicine, University of Oslo, Norway.
    2016 European Guideline on the management of non-gonococcal urethritis2016In: International Journal of STD and AIDS (London), ISSN 0956-4624, E-ISSN 1758-1052, Vol. 27, no 11, 928-937 p.Article in journal (Refereed)
    Abstract [en]

    We present the updated International Union against Sexually Transmitted Infections guideline for the management of non-gonococcal urethritis in men. This guideline recommends confirmation of urethritis in symptomatic men before starting treatment. It does not recommend testing asymptomatic men for the presence of urethritis. All men with urethritis should be tested for Chlamydia trachomatis and Neisseria gonorrhoeae and ideally M. genitalium using a NAAT as this is highly likely to improve clinical outcomes. If a NAAT is positive for gonorrhoea, a culture should be performed before treatment. In view of the increasing evidence that azithromycin 1 g may result in the development of antimicrobial resistance in Mycoplasma genitalium azithromycin 1 g is no longer recommended as first line therapy, which should be doxycycline 100 mg bd for 7 days. If azithromycin is to be prescribed an extended of 500 mg, then 250 mg daily for 4 days is to be preferred over 1 g stat. In men with persistent NGU, M. genitalium NAAT testing is recommended if not previously undertaken, as is Trichomonas vaginalis NAAT testing in populations where T. vaginalis is detectable in >2% of symptomatic women.

  • 7.
    Inganäs, Olle
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Admassie, Shimelis
    University of Addis Ababa, Ethiopia .
    25th Anniversary Article: Organic Photovoltaic Modules and Biopolymer Supercapacitors for Supply of Renewable Electricity: A Perspective from Africa2014In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 26, no 6, 830-847 p.Article, review/survey (Refereed)
    Abstract [en]

    The role of materials in civilization is well demonstrated over the centuries and millennia, as materials have come to serve as the classifier of stages of civilization. With the advent of materials science, this relation has become even more pronounced. The pivotal role of advanced materials in industrial economies has not yet been matched by the influence of advanced materials during the transition from agricultural to modern societies. The role of advanced materials in poverty eradication can be very large, in particular if new trajectories of social and economic development become possible. This is the topic of this essay, different in format from the traditional scientific review, as we try to encompass not only two infant technologies of solar energy conversion and storage by means of organic materials, but also the social conditions for introduction of the technologies. The development of organic-based photovoltaic energy conversion has been rapid, and promises to deliver new alternatives to well-established silicon photovoltaics. Our recent development of organic biopolymer composite electrodes opens avenues towards the use of renewable materials in the construction of wooden batteries or supercapacitors for charge storage. Combining these new elements may give different conditions for introduction of energy technology in areas now lacking electrical grids, but having sufficient solar energy inputs. These areas are found close to the equator, and include some of the poorest regions on earth.

  • 8.
    Gehlert, Donald R.
    et al.
    Eli Lilly and Company, Indianapolis, IN, USA.
    Cippitelli, Andrea
    National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA.
    Thorsell, Annika
    National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA.
    Lê, Anh Dzung
    University of Toronto, Canada.
    Hipskind, Philip A
    Eli Lilly and Company, Indianapolis, IN, USA.
    Hamdouchi, Chafiq
    Eli Lilly and Company, Indianapolis, IN, USA.
    Lu, Jianliang
    Eli Lilly and Company, Indianapolis, IN, USA.
    Hembre, Erik J.
    Eli Lilly and Company, Indianapolis, IN, USA.
    Cramer, Jeffrey
    Eli Lilly and Company, Indianapolis, IN, USA.
    Song, Min
    Eli Lilly and Company, Indianapolis, IN, USA.
    McKinzie, David
    Eli Lilly and Company, Indianapolis, IN, USA.
    Morin, Michelle
    Eli Lilly and Company, Indianapolis, IN, USA.
    Ciccocioppo, Roberto
    University of Camerino, Italy.
    Heilig, Markus
    National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA.
    3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism2007In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 27, no 10, 2718-2726 p.Article in journal (Refereed)
    Abstract [en]

    We describe a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with advantageous properties for clinical development, and its in vivo activity in preclinical alcoholism models. 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine (MTIP) inhibited 125I-sauvagine binding to rat pituitary membranes and cloned human CRF1 with subnanomolar affinities, with no detectable activity at the CRF2 receptor or other common drug targets. After oral administration to rats, MTIP inhibited 125I-sauvagine binding to rat cerebellar membranes ex vivo with an ED50 of approximately 1.3 mg/kg and an oral bioavailability of 91.1%. Compared with R121919 (2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylamino-pyrazolo[1,5-a]pyrimidine) and CP154526 (N-butyl-N-ethyl-4,9-dimethyl-7-(2,4,6-trimethylphenyl)-3,5,7-triazabicyclo[4.3.0]nona-2,4,8,10-tetraen-2-amine), MTIP had a markedly reduced volume of distribution and clearance. Neither open-field activity nor baseline exploration of an elevated plus-maze was affected by MTIP (1-10 mg/kg). In contrast, MTIP dose-dependently reversed anxiogenic effects of withdrawal from a 3 g/kg alcohol dose. Similarly, MTIP blocked excessive alcohol self-administration in Wistar rats with a history of dependence, and in a genetic model of high alcohol preference, the msP rat, at doses that had no effect in nondependent Wistar rats. Also, MTIP blocked reinstatement of stress-induced alcohol seeking both in postdependent and in genetically selected msP animals, again at doses that were ineffective in nondependent Wistar rats. Based on these findings, MTIP is a promising candidate for treatment of alcohol dependence.

  • 9.
    Li, Wei
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences.
    Yuan, Ximing
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine.
    Ivanova, S.
    Laboratory of Biomedical Science, North Shore-LIE Research Institute, Manhasset, NY 11030, United States.
    Tracey, K.J.
    Laboratory of Biomedical Science, North Shore-LIE Research Institute, Manhasset, NY 11030, United States.
    Eaton, John Wallace
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Experimental Pathology . Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
    Brunk, Ulf
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Pharmacology .
    3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin2003In: Biochemical Journal, ISSN 0264-6021, Vol. 371, no 2, 429-436 p.Article in journal (Refereed)
    Abstract [en]

    Cytotoxic polyamine-derived amino aldehydes, formed during cerebral ischaemia, damage adjacent tissue (the so-called 'penumbra') not subject to the initial ischaemic insult. One such product is 3-aminopropanal (3-AP), a potent cytotoxin that accumulates in ischaemic brain, although the precise mechanisms responsible for its formation are still unclear. More relevant to the present investigations, the mechanisms by which such a small aldehydic compound might be cytotoxic are also not known, but we hypothesized that 3-AP, having the structure of a weak lysosomotropic base, might concentrate within lysosomes, making these organelles a probable focus of initial toxicity. Indeed, 3-AP leads to lysosomal rupture of D384 glioma cells, a process which clearly precedes caspase activation and apoptotic cell death. Immunohistochemistry reveals that 3-AP concentrates in the lysosomal compartment and prevention of this accumulation by the lysosomotropic base ammonia, NH3, protects against 3-AP cytotoxicity by increasing lysosomal pH. A thiol compound, N-(2-mercaptopropionyl)glycine, reacts with and neutralizes 3-AP and significantly inhibits cytoxocity. Both amino and aldehyde functions of 3-AP are necessary for toxicity: the amino group confers lysosomotropism and the aldehyde is important for additional, presently unknown, reactions. We conclude that 3-AP exerts its toxic effects by accumulating intralysosomally, causing rupture of these organelles and releasing lysosomal enzymes which initiate caspase activation and apoptosis (or necrosis if the lysosomal rupture is extensive). These results may have implications for the development of new therapeutics designed to lessen secondary damage arising from focal cerebral ischaemia.

  • 10.
    Ong, Jeb A.
    et al.
    Maisonneuve Rosemt Hospital, Canada; University of Montreal, Canada.
    Auvinet, Edouard
    University of Montreal, Canada.
    Forget, Karolyn J.
    Maisonneuve Rosemt Hospital, Canada.
    Lagali, Neil
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
    Fagerholm, Per
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.
    Griffith, May
    Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Maisonneuve Rosemt Hospital, Canada.
    Meunier, Jean
    University of Montreal, Canada; University of Montreal, Canada.
    Brunette, Isabelle
    Maisonneuve Rosemt Hospital, Canada; University of Montreal, Canada.
    3D Corneal Shape After Implantation of a Biosynthetic Corneal Stromal Substitute2016In: Investigative Ophthalmology and Visual Science, ISSN 0146-0404, E-ISSN 1552-5783, Vol. 57, no 6, 2355-2365 p.Article in journal (Refereed)
    Abstract [en]

    PURPOSE. The current and projected shortage of transplantable human donor corneas has prompted the development of long-term alternatives to human donor tissue for corneal replacement. The biosynthetic stromal substitutes (BSS) characterized herein represent a potentially safe alternative to donor organ transplantation for anterior corneal stromal diseases. The goal of this phase 1 safety study was to characterize the three-dimensional (3D) corneal shape of the first 10 human patients implanted with a BSS and assess its stability over time. METHODS. Ten patients underwent anterior lamellar keratoplasty using a biosynthetic corneal stromal implant for either advanced keratoconus or central corneal scarring. Surgeries were performed at Linkoping University Hospital, between October and November 2007. Serial corneal topographies were performed on all eyes up to a 4-year follow-up when possible. Three-dimensional shape average maps were constructed for the 10 BSS corneas and for 10 healthy controls. Average 3D shape corneal elevation maps, difference maps, and statistics maps were generated. RESULTS. The biosynthetic stromal substitutes implants remained stably integrated into the host corneas over the 4-year follow-up period, without signs of wound dehiscence or implant extrusion. The biosynthetic stromal substitutes corneas showed steeper surface curvatures and were more irregular than the healthy controls. CONCLUSIONS. Corneal astigmatism and surface steepness were observed 4 years after BSS implantation, while the implants remained stably integrated in the host corneas. Future studies will indicate if biomaterials technology will allow for the optimization of postoperative surface irregularity after anterior stromal replacement, a new window of opportunity that is not available with traditional corneal transplantation techniques.

  • 11.
    Waernér, Mikael
    Linköping University, Department of Electrical Engineering, Information Coding. Linköping University, The Institute of Technology.
    3D Graphics Technologies for Web Applications: An Evaluation from the Perspective of a Real World Application2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Web applications are becoming increasingly sophisticated and functionality that was once exclusive to regular desktop applications can now be found in web applications as well. One of the more recent advances in this field is the ability for web applications to render 3D graphics. Coupled with the growing number of devices with graphics processors and the ability of web applications to run on many different platforms using a single code base, this represents an exciting new possibility for developers of 3D graphics applications.

    This thesis aims to explore and evaluate the technologies for 3D graphics that can be used in web applications, with the final goal of using one of them in a prototype application. This prototype will serve as a foundation for an application to be included in a commercial product. The evaluation is performed using general criteria so as to be useful for other applications as well, with one part presenting the available technologies and another part evaluating the three most promising technologies more in-depth using test programs.

    The results show that, although some technologies are not production-ready, there are a few which can be used in commercial software, including the three chosen for further evaluation; WebGL, the Java library JOGL and Stage 3D for Flash. Among these, there is no clear winner and it is up to the application requirements to decide which to use. The thesis demonstrates an application built with WebGL and shows that fairly demanding 3D graphics web applications can be built. Also included are the lessons learned during the development and thoughts on the future of 3D graphics in web applications.

  • 12.
    Markström, Johannes
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    3D Position Estimation of a Person of Interest in Multiple Video Sequences: People Detection2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In most cases today when a specific person's whereabouts is monitored through video surveillance it is done manually and his or her location when not seen is based on assumptions on how fast he or she can move. Since humans are good at recognizing people this can be done accurately, given good video data, but the time needed to go through all data is extensive and therefore expensive. Because of the rapid technical development computers are getting cheaper to use and therefore more interesting to use for tedious work.

    This thesis is a part of a larger project that aims to see to what extent it is possible to estimate a person of interest's time dependent 3D position, when seen in surveillance videos. The surveillance videos are recorded with non overlapping monocular cameras. Furthermore the project aims to see if the person of interest's movement, when position data is unavailable, could be predicted. The outcome of the project is a software capable of following a person of interest's movement with an error estimate visualized as an area indicating where the person of interest might be at a specific time.

    This thesis main focus is to implement and evaluate a people detector meant to be used in the project, reduce noise in position measurement, predict the position when the person of interest's location is unknown, and to evaluate the complete project.

    The project combines known methods in computer vision and signal processing and the outcome is a software that can be used on a normal PC running on a Windows operating system. The software implemented in the thesis use a Hough transform based people detector and a Kalman filter for one step ahead prediction. The detector is evaluated with known methods such as Miss-rate vs. False Positives per Window or Image (FPPW and FPPI respectively) and Recall vs. 1-Precision.

    The results indicate that it is possible to estimate a person of interest's 3D position with single monocular cameras. It is also possible to follow the movement, to some extent, were position data are unavailable. However the software needs more work in order to be robust enough to handle the diversity that may appear in different environments and to handle large scale sensor networks.

  • 13.
    Comina, German
    et al.
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, Faculty of Science & Engineering.
    Suska, Anke
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    Filippini, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Chemical and Optical Sensor Systems. Linköping University, Faculty of Science & Engineering.
    3D printed disposable optics and lab-on-a-chip devices for chemical sensing with cell phones2017In: MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS XV, SPIE-INT SOC OPTICAL ENGINEERING , 2017, Vol. 10061, UNSP 100610EConference paper (Refereed)
    Abstract [en]

    Digital manufacturing (DM) offers fast prototyping capabilities and great versatility to configure countless architectures at affordable development costs. Autonomous lab-on-a-chip (LOC) devices, conceived as only disposable accessory to interface chemical sensing to cell phones, require specific features that can be achieved using DM techniques. Here we describe stereo-lithography 3D printing (SLA) of optical components and unibody-LOC (ULOC) devices using consumer grade printers. ULOC devices integrate actuation in the form of check-valves and finger pumps, as well as the calibration range required for quantitative detection. Coupling to phone camera readout depends on the detection approach, and includes different types of optical components. Optical surfaces can be locally configured with a simple polishing-free post-processing step, and the representative costs are 0.5 US$/device, same as ULOC devices, both involving fabrication times of about 20 min.

  • 14.
    Lång, Magnus
    Linköping University, The Institute of Technology. Linköping University, Department of Science and Technology.
    3D Teleconferencing: The construction of a fully functional, novel 3D Teleconferencing system2009Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This report summarizes the work done to develop a 3D teleconferencing system, which enables remote participants anywhere in the world to be scanned in 3D, transmitted and displayed on a constructed 3D display with correct vertical and horizontal parallax, correct eye contact and eye gaze. The main focus of this report is the development of this system and especially how to in an efficient and general manner render to the novel 3D display. The 3D display is built out of modified commodity hardware and show a 3D scene for observers in up to 360 degrees around it and all heights. The result is a fully working 3D Teleconferencing system, resembling communication envisioned in movies such as holograms from Star Wars. The system transmits over the internet, at similar bandwidth requirements as concurrent 2D videoconferencing systems.

  • 15.
    Helgesson, Robin
    et al.
    Linköping University, Department of Management and Engineering, Carl Malmsten - furniture studies.
    Dudzina, Ela
    Linköping University, Department of Management and Engineering, Carl Malmsten - furniture studies.
    3D-Teknik: ett användbart hjälpmedel för möbelkonservering?2016Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    This thesis seeks to explain how the various 3D-technologies can serve as a practical aid in applied furniture conservation. The thesis deals with various techniques to scan and print, presents a selection of previous research relevant to the topic, and provides insight into the practical case studies.

    The technical development of 3D printing and scanning is advancing rapidly which raises the question whether the technology can be a useful tool in the field of conservation. The thesis presents a number of case studies where 3D technology has been used for documentation and restoration of various objects. These techniques have been compared with conventional methods.

    PLA is a printing fillament, perhaps primarily intended for commercial use. The work examines this material and its compatibility with other materials. After aging, the fillament undergoes a structural and color test. The results show that PLA is sensitive to UV-radiation and temperatures above 60°C. We believe that 3D technology can, in many cases, serve as a useful tool for furniture preservation.

  • 16.
    Winell, Johan
    Linköping University, Department of Science and Technology.
    3D-visualisering av robotsimulering2001Independent thesis Basic level (professional degree)Student thesis
    Abstract [en]

    Visualization is a rapidly growing area of computer graphics. Due to the very progressive development of computer technology and especially 3D-graphic boards yesterdays imagination of visualizations, today is a reality.

    At Saab Bofors Dynamics in Linköping missile systems are developed. Through the development, different subsystems are simulated before the manufacturing starts. The results of these simulations have to be visualized to get a meaning. The visualizations can be symbolic or more real looking 3D-visualizations.

    During the work an investigation of available tools for computer visualizations on the market has been conducted. The outcome of the investigation has later been the foundation for the selection of tools to solve the visualization task.

    One 3D-visualization application for general 3D-visualization has then been developed using two different 3D-APIs, and the experiences of these have then been analyzed.

  • 17.
    Sanjuan, Joseba
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    3G Energy-Efficient Packet Handling Kernel Module for Android2012Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    The use of mobile devices is increasing due to the constant development of more advanced and appealing applications and computing features. However, these new features are very power hungry leading to short battery lifetimes. Research shows that a major reason for fast battery depletion is the excessive and inefficient use of the wireless interfaces. This thesis studies how we can attempt to increase the battery lifetime of the devices without having to sacrifice the usage of these advanced features in some applications.

    The thesis focuses on adapting the traffic pattern characteristics of mobile communication using a widespread wireless communication technology like 3G. Traffic pattern adaptation is performed at packet level in kernel space in Android. The data transfers are scheduled with the knowledge of the energy consumption characteristics of 3G. The performed measurements indicate that our solution can provide energy savings ranging from 7% to 59%.

    This work confirms that 3G conscious scheduling of network traffic reduces energy consumption, and that, both applications and energy saving libraries are potential directions to be further studied.

  • 18.
    Clark, Charlotte
    et al.
    Queen Mary University of London, UK.
    Sörqvist, Patrik
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences.
    3 year update on research on effects of noise on health and behaviour2010Conference paper (Refereed)
  • 19.
    Dyverfeldt, Petter
    et al.
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Bissell, Malenka
    University of Oxford, England.
    Barker, Alex J.
    Northwestern University, IL 60611 USA.
    Bolger, Ann F
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. University of Calif San Francisco, CA USA.
    Carlhäll, Carljohan
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Ebbers, Tino
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).
    Francios, Christopher J.
    University of Wisconsin, WI 53706 USA.
    Frydrychowicz, Alex
    University Hospital Schleswig Holstein, Germany.
    Geiger, Julia
    University of Childrens Hospital Zurich, Switzerland.
    Giese, Daniel
    University Hospital Cologne, Germany.
    Hope, Michael D.
    University of Calif San Francisco, CA USA.
    Kilner, Philip J.
    University of London Imperial Coll Science Technology and Med, England.
    Kozerke, Sebastian
    University of Zurich, Switzerland; ETH, Switzerland.
    Myerson, Saul
    University of Oxford, England.
    Neubauer, Stefan
    University of Oxford, England.
    Wieben, Oliver
    University of Wisconsin, WI 53706 USA.
    Markl, Michael
    Northwestern University, IL 60611 USA; Northwestern University, IL 60611 USA.
    4D flow cardiovascular magnetic resonance consensus statement2015In: Journal of Cardiovascular Magnetic Resonance, ISSN 1097-6647, E-ISSN 1532-429X, Vol. 17, no 72Article, review/survey (Refereed)
    Abstract [en]

    Pulsatile blood flow through the cavities of the heart and great vessels is time-varying and multidirectional. Access to all regions, phases and directions of cardiovascular flows has formerly been limited. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) has enabled more comprehensive access to such flows, with typical spatial resolution of 1.5x1.5x1.5 - 3x3x3 mm(3), typical temporal resolution of 30-40 ms, and acquisition times in the order of 5 to 25 min. This consensus paper is the work of physicists, physicians and biomedical engineers, active in the development and implementation of 4D Flow CMR, who have repeatedly met to share experience and ideas. The paper aims to assist understanding of acquisition and analysis methods, and their potential clinical applications with a focus on the heart and greater vessels. We describe that 4D Flow CMR can be clinically advantageous because placement of a single acquisition volume is straightforward and enables flow through any plane across it to be calculated retrospectively and with good accuracy. We also specify research and development goals that have yet to be satisfactorily achieved. Derived flow parameters, generally needing further development or validation for clinical use, include measurements of wall shear stress, pressure difference, turbulent kinetic energy, and intracardiac flow components. The dependence of measurement accuracy on acquisition parameters is considered, as are the uses of different visualization strategies for appropriate representation of time-varying multidirectional flow fields. Finally, we offer suggestions for more consistent, user-friendly implementation of 4D Flow CMR acquisition and data handling with a view to multicenter studies and more widespread adoption of the approach in routine clinical investigations.

  • 20. Sastry, M
    et al.
    Gustafsson, Håkan
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiation Physics.
    Lund, Anders
    Linköping University, Department of Physics, Chemistry and Biology.
    Lund, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radiation Physics. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics.
    51V(n,β)52Cr reaction for neutron dosimetry: Development and assessment of a spectrophotometric method for determination of Cr in vanadium at sub ppm level2004In: Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, Vol. 60, no 10, 2363-2367 p.Article in journal (Refereed)
    Abstract [en]

    With a view to monitoring the changes in coloration caused by the nuclear reaction 51V(n,β)52Cr in solution of vanadyl sulphate and using it for neutron dosimetry, electronic absorption spectra of vanadyl sulphate solutions were investigated at different concentrations of chromate impurity in micromolar range. It was observed that the presence of chromate enhances the absorptivity over a wide wavelength range serving essentially as a colouring agent for vanadium matrix, presumably due to charge transfer process. The absorbance at 380nm varied linearly over a wide concentration range. The limit of detection of chromate obtained is shown to be adequate for detecting neutron-induced chemical transmutation of vanadium to chromium under standard reactor conditions, when used with long path length cells. It was observed that the absorbance does not change on electron irradiation, suggesting that radiolytic effects due to beta decay, if any, do not interfere in the measurement of neutron-induced changes. In addition to its potential for neutron dosimetry, this is the first report of a simple and direct method of estimation of Cr in vanadium matrix at sub ppm level.

  • 21.
    Andersson, Gerhard
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences. Karolinska Institute, Sweden.
    Topooco, Naira
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Havik, Odd
    University of Bergen, Norway; Haukeland Hospital, Norway.
    Nordgreen, Tine
    University of Bergen, Norway; Haukeland Hospital, Norway.
    6 Internet-supported versus face-to-face cognitive behavior therapy for depression2016In: Expert Review of Neurotherapeutics, ISSN 1473-7175, E-ISSN 1744-8360, Vol. 16, no 1, 55-60 p.Article, review/survey (Refereed)
    Abstract [en]

    Major depression and depressive symptoms are highly prevalent and there is a need for different forms of psychological treatments that can be delivered from a distance at a low cost. In the present review the authors contrast face-to-face and Internet-delivered cognitive behavior therapy (ICBT) for depression. A total of five studies are reviewed in which guided ICBT was directly compared against face-to-face CBT. Meta-analytic summary statistics were calculated for the five studies involving a total of 429 participants. The average effect size difference was Hedges g=0.12 (95% CI: -0.06-0.30) in the direction of favoring guided ICBT. The small difference in effect has no implication for clinical practice. The overall empirical status of clinician-guided ICBT for depression is commented on and future challenges are highlighted. Among these are developing treatments for patients with more severe and long-standing depression and for children, adolescents and the elderly. Also, there is a need to investigate mechanisms of change.

  • 22.
    Zuse, Ann
    et al.
    Institute of Medicinal and Pharmaceutical Chemistry, Westphalian Wilhelms-University, Hittorfstrasse 58-62, D-48149 Münster, Germany; Manitoba Institute of Cell Biology, CancerCare Manitoba, Department of Biochemistry and Medical Genetics, Winnipeg, Canada.
    Prinz, Helge
    Institute of Medicinal and Pharmaceutical Chemistry, Westphalian Wilhelms-University, Hittorfstrasse 58-62, D-48149 Münster, Germany.
    Müller, Klaus
    Institute of Medicinal and Pharmaceutical Chemistry, Westphalian Wilhelms-University, Hittorfstrasse 58-62, D-48149 Münster, Germany.
    Schmidt, Peter
    Zentaris GmbH, Weismüllerstrasse 50, D-60314 Frankfurt, Germany.
    Günther, Eckhard G.
    Zentaris GmbH, Weismüllerstrasse 50, D-60314 Frankfurt, Germany.
    Schweizer, Frank
    Department of Chemistry, Univ. Manitoba, Winnipeg, Canada.
    Prehn, Jochen H.M.
    Department of Physiology and RCSI Research Institute, St. Stephen's Green, Dublin, Ireland.
    Los, Marek Jan
    Manitoba Institute of Cell Biology, Cancer Care Manitoba; Manitoba Institute of Child Health; Department of Biochemistry and Medical Genetics; Department of Human Anatomy and Cell Science, University Manitoba, Winnipeg, Canada, .
    9-benzylidene-naphtho[2,3-b]thiophen-4-ones and benzylidene-9(10H)-anthracenones as novel tubulin interacting agents with high apoptosis-inducing activity2007In: European Journal of Pharmacology, ISSN 0014-2999, E-ISSN 1879-0712, Vol. 575, no 1-3, 34-45 p.Article in journal (Refereed)
    Abstract [en]

    Tubulin-binding 9-benzylidene-naphtho[2,3-b]thiophen-4-ones 1a and 1b and benzylidene-9(10H)-anthracenone 2 were evaluated for their ability to induce cell death. We examined the effect of the molecules on cell cycle progression, organization of microtubule networks, and apoptosis induction. As determined by flow cytometry, cancer cells were predominantly arrested in metaphase with 4N DNA before cell death occurred. By using indirect immunofluorescence techniques we visualized microtubule depolymerization recognizable by short microtubule fragments scattered around the nucleus. The incubation with 1a and 2 resulted in chromatin condensation, nuclear fragmentation, and cell shrinkage, which are, among others, typical features of apoptotic cell death. Furthermore, time- and dose-dependent induction of apoptosis in SH-SY5Y cells was detected via cleavage of Ac-DEVD-AMC, a fluorigenic substrate for caspase-3. We observed a lower apoptotic activity in neuroblastoma cells overexpressing Bcl-xL, suggesting activation of the mitochondrial apoptosis pathway. Western blot analysis demonstrated that caspase-3, an apoptosis mediator, was activated in a time-dependent manner after exposure of SH-SY5Y cells to drugs 1a and 2. Taken together, the agents investigated in the present study display strong apoptosis-inducing activity and therefore show promise for the development of novel chemotherapeutics.

  • 23.
    Andersson, Gerhard
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Hesser, Hugo
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Hummerdal, Daniel
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Arts and Sciences.
    Bergman Nordgren, Lise
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Arts and Sciences.
    Carlbring, Per
    Linköping University, The Swedish Institute for Disability Research. Linköping University, Faculty of Arts and Sciences. Department of Psychology , Umeå University, Umeå, Sweden.
    A 3.5-year follow-up of Internet-delivered cognitive behavior therapy for major depression2013In: Journal of Mental Health, ISSN 0963-8237, E-ISSN 1360-0567, Vol. 22, no 2, 155-164 p.Article in journal (Refereed)
    Abstract [en]

    BackgroundInternet-delivered cognitive behavior therapy (ICBT) for major depression has been tested in several trials, but only with follow-ups up to 1.5 years.

    AimThe aim of this study was to evaluate the outcome of ICBT 3.5 years after treatment completion.Methods

    A total of 88 people with major depression were randomized to either guided self-help or e-mail therapy in the original trial. One-third was initially on a waiting-list. Treatment was provided for eight weeks and in this report long-term follow-up data were collected. Also included were data from post-treatment and six-month follow-up. A total of 58% (51/88) completed the 3.5-year follow-up. Analyses were performed using a random effects repeated measures piecewise growth model to estimate trajectory shape over time and account for missing data.

    ResultsResults showed continued lowered scores on the Beck Depression Inventory (BDI). No differences were found between the treatment conditions. A large proportion of participants (55%) had sought and received additional treatments in the follow-up period. A majority (56.9%) of participants had a BDI score lower than 10 at the 3.5-year follow-up.

    ConclusionsPeople with mild to moderate major depression may benefit from ICBT 3.5-years after treatment completion.

  • 24.
    Braian, Clara
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Svensson, Mattias
    Karolinska Institute, Sweden.
    Brighenti, Susanna
    Karolinska Institute, Sweden.
    Lerm, Maria
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Parasa, Venkata R.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Karolinska Institute, Sweden.
    A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection2015In: Journal of Visualized Experiments, ISSN 1940-087X, E-ISSN 1940-087X, no 104, 1-9 p., e53084Article in journal (Refereed)
    Abstract [en]

    Tuberculosis (TB) still holds a major threat to the health of people worldwide, and there is a need for cost-efficient but reliable models to help us understand the disease mechanisms and advance the discoveries of new treatment options. In vitro cell cultures of monolayers or co-cultures lack the three-dimensional (3D) environment and tissue responses. Herein, we describe an innovative in vitro model of a human lung tissue, which holds promise to be an effective tool for studying the complex events that occur during infection with Mycobacterium tuberculosis (M. tuberculosis). The 3D tissue model consists of tissue-specific epithelial cells and fibroblasts, which are cultured in a matrix of collagen on top of a porous membrane. Upon air exposure, the epithelial cells stratify and secrete mucus at the apical side. By introducing human primary macrophages infected with M. tuberculosis to the tissue model, we have shown that immune cells migrate into the infected-tissue and form early stages of TB granuloma. These structures recapitulate the distinct feature of human TB, the granuloma, which is fundamentally different or not commonly observed in widely used experimental animal models. This organotypic culture method enables the 3D visualization and robust quantitative analysis that provides pivotal information on spatial and temporal features of host cell-pathogen interactions. Taken together, the lung tissue model provides a physiologically relevant tissue micro-environment for studies on TB. Thus, the lung tissue model has potential implications for both basic mechanistic and applied studies. Importantly, the model allows addition or manipulation of individual cell types, which thereby widens its use for modelling a variety of infectious diseases that affect the lungs.

  • 25.
    Lindgren, Christer
    et al.
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Oral Surgery UHL.
    Mordenfeld, Arne
    Department of Oral and Maxillofacial Surgery, Gävle, County Hospital, Sweden/Dept of Biomaterials, Institute of Clinical Sciences, Göteborg University, Sweden.
    Johansson, CB
    School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Hallman, Mats
    Department of Oral and Maxillofacial Surgery, Gävle, County Hospital, Sweden/Department of Oral & Maxillofacial Surgery, Umeå University, Umeå Sweden and Center for Research and Development, Uppsala University/Gävleborg County Council, Sweden.
    A 3-year clinical follow-up of implants placed in 2 differentbiomaterials used for sinus augmentationManuscript (preprint) (Other academic)
    Abstract [en]

    Purpose: The aims of the present study were to compare a novel biphasic calcium phosphate (BCP) with deproteinized bovine bone (DBB) used for maxillary sinus floor augmentation (MSFA) in a split mouth design, and to perform a clinical follow-up of placed dental implants.

    Material and Methods: Nine completely edentulous patients and two partially edentulous patients with a mean age of 67 years requiring bilateral sinus augmentation were included in the study. The patients were randomized for augmentation with BCP (test) and DBB (control) in the contralateral side. After 8 months of graft healing, 62 implants with an SLActive® surface (Strauman®, Basel, Switzerland) were placed. After 3 years of graft healing core biopsies were obtained from the grafted areas for histological and histomorphometrical analysis. After 3 years of functional implant loading, implant survival/success rate, clinical indexes, radiographical examination and resonance frequency analysis (RFA) wereperformed.

    Results: The mean values of the area of newly formed bone in the biopsies was 29% ±14.3% and 32% ± 18.0% for BCP and DBB respectively and graft particles in contact with bone in the BCP group was 38% ± 10.9% compared to 44% ± 12.1% for the DBB group, showing no significant differences between the groups. The mean values of the area of BCP particles and DBB particles were 20% ± 7.5% and 24% ± 13.5% respectively (non-significant).

    Irrespective of particles used, one dental implant was lost from each group, giving an overall implant survival rate of 96.8% after 3-years of loading. Conclusion: The results of this prospective 3-year clinical and histological follow up demonstrated a similar amount of newly formed bone irrespectively of the used biomaterial. The choice of biomaterial does not seem to influence the survival rates of the implants.

  • 26.
    Hedman, Erik
    et al.
    Karolinska University Hospital.
    Furmark, Tomas
    Uppsala University.
    Carlbring, Per
    Umea University.
    Ljotsson, Brjann
    Karolinska University Hospital.
    Ruck, Christian
    Karolinska University Hospital.
    Lindefors, Nils
    Karolinska University Hospital.
    Andersson, Gerhard
    Linköping University, Department of Behavioural Sciences and Learning, Clinical and Social Psychology. Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Behavioural Sciences and Learning, Psychology.
    A 5-Year Follow-up of Internet-Based Cognitive Behavior Therapy for Social Anxiety Disorder2011In: Journal of Medical Internet Research, ISSN 1438-8871, Vol. 13, no 2Article in journal (Refereed)
    Abstract [en]

    Background: Internet-based cognitive behavior therapy (CBT) has been shown to be a promising method to disseminate cognitive behavior therapy for social anxiety disorder (SAD). Several trials have demonstrated that Internet-based CBT can be effective for SAD in the shorter term. However, the long-term effects of Internet-based CBT for SAD are less well known. less thanbrgreater than less thanbrgreater thanObjective: Our objective was to investigate the effect of Internet-based CBT for SAD 5 years after completed treatment. less thanbrgreater than less thanbrgreater thanMethod: We conducted a 5-year follow-up study of 80 persons with SAD who had undergone Internet-based CBT. The assessment comprised a diagnostic interview and self-report questionnaires. The main outcome measure was the Liebowitz Social Anxiety Scale-Self-Report (LSAS-SR). Additional measures of social anxiety were the Social Interaction Anxiety Scale (SIAS) and the Social Phobia Scale (SPS). Attrition rates were low: 89% (71/80) of the participants completed the diagnostic interview and 80% (64/80) responded to the questionnaires. less thanbrgreater than less thanbrgreater thanResults: Mixed-effect models analysis showed a significant effect of time on the three social anxiety measures, LSAS-SR, SIAS, and SPS (F(3,98-102) = 16.05 -29.20, P andlt; .001) indicating improvement. From baseline to 5-year follow-up, participants mean scores on the LSAS-SR were reduced from 71.3 (95% confidence interval [CI] 66.1-76.5) to 40.3 (95% CI 35.2 - 45.3). The effect sizes of the LSAS-SR were large (Cohens d range 1.30 - 1.40, 95% CI 0.77 - 1.90). Improvements gained at the 1-year follow-up were sustained 5 years after completed treatment. less thanbrgreater than less thanbrgreater thanConclusions: Internet-based CBT for SAD is a treatment that can result in large and enduring effects. Trial registration: Clinicaltrials.gov NCT01145690; http://clinicaltrials.gov/ct2/show/NCT01145690 (Archived by WebCite at http://www.webcitation.org/5ygRxDLfK)

  • 27.
    Aifa, Sami
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
    Aydin, J
    Nordvall, G
    Lundström, Ingemar
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Svensson, Samuel
    Hermanson, O
    A basic peptide within the juxtamembrane region is required for EGF receptor dimerization2005In: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 302, no 1, 108-114 p.Article in journal (Refereed)
    Abstract [en]

    The epidermal growth factor receptor (EGFR) is fundamental for normal cell growth and organ development, but has also been implicated in various pathologies, notably tumors of epithelial origin. We have previously shown that the initial 13 amino acids (P13) within the intracellular juxtamembrane region (R645-R657) are involved in the interaction with calmodulin, thus indicating an important role for this region in EGFR function. Here we show that P13 is required for proper dimerization of the receptor. We expressed either the intracellular domain of EGFR (TKJM) or the intracellular domain lacking P13 (ΔTKJM) in COS-7 cells that express endogenous EGFR. Only TKJM was immunoprecipitated with an antibody directed against the extracellular part of EGFR, and only TKJM was tyrosine phosphorylated by endogenous EGFR. Using SK-N-MC cells, which do not express endogenous EGFR, that were stably transfected with either wild-type EGFR or recombinant full-length EGFR lacking P13 demonstrated that P13 is required for appropriate receptor dimerization. Furthermore, mutant EGFR lacking P13 failed to be autophosphorylated. P13 is rich in basic amino acids and in silico modeling of the EGFR in conjunction with our results suggests a novel role for the juxtamembrane domain (JM) of EGFR in mediating intracellular dimerization and thus receptor kinase activation and function. © 2004 Elsevier Inc. All rights reserved.

  • 28.
    Lindblad, Ulrik
    et al.
    Linköping University, Department of Electrical Engineering.
    Thalin, Patrik
    Linköping University, Department of Electrical Engineering.
    A Behavioral Model of a DSP Processor with Scalable Structure2002Independent thesis Basic level (professional degree)Student thesis
    Abstract [en]

    In mobile digital devices, low power consumption is an important matter to reduce the need for a heavy and big battery. One way of reducing the power consumption is to construct the hardware so that the performance is optimal for the application. The demand of performance is dependent of the tasks that the device will be performing. This is where scalable structure of the hardware is an idea to solve the problem.

    This master thesis serve as a starting point for developing a digital signal processor with scalable structure. The digital signal processor is a common and important part of digital processing. Scalable struture is in this case adding and removing parts of the memory and/or the instruction set, and to make the data wordlength variable. The development is simplified by modeling it on an existing processor. The result of this master thesis is an instruction simulator written in C language. The simulator will be a model for development of the hardware.

  • 29.
    Furberg, Bibbi
    Linköping University, Department of Computer and Information Science.
    A better DREAM?: Utvärdering och utveckling av en metod för analys av olyckor inom biltrafikdomänen.2004Independent thesis Advanced level (degree of Magister)Student thesis
    Abstract [sv]

    Denna uppsats är en del av trafiksäkerhetsprojektet FICA (Factors Influencing the Causation of Accidents and Incidents), vars målsättning är att genom en förståelse för förarbeteende kunna utveckla aktiv säkerhetsteknologi för fordon. Inom detta projekt kommer en metod för olycksanalys, DREAM (Driving Reliability and Error Analysis Method), att användas. Den här uppsatsen handlar om att utvärdera och utveckla denna analysmetod. Arbetet med metoden har främst gällt användbarhetsaspekter av DREAM. Även olika kvalitetsaspekter som till exempel replikerbarhet, har undersökts. Arbetet har skett genom ett antal studier där DREAM tillämpats på olycksmaterial. DREAM har bland annat testats genom en kooperativ utvärdering där testpersonerna fick"tänka högt"medan de utförde analysen. Arbetet resulterade i vissa förändringar i den befintliga metoden, samt i en manual till DREAM och mallar att fylla i vid en analys.

  • 30.
    Zhang, Yingfeng
    et al.
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China.
    Ren, Shan
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China; Department of Mechanical Engineering, Honghe University, Yunnan, PR China.
    Liu, Yang
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering. Department of Production, University of Vaasa, Vaasa, Finland.
    Si, Shubin
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China.
    A big data analytics architecture for cleaner manufacturing and maintenance processes of complex products2017In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 142, no 2, 626-641 p.Article in journal (Refereed)
    Abstract [en]

    Cleaner production (CP) is considered as one of the most important means for manufacturing enterprises to achieve sustainable production and improve their sustainable competitive advantage. However, implementation of the CP strategy was facing barriers, such as the lack of complete data and valuable knowledge that can be employed to provide better support on decision-making of coordination and optimization on the product lifecycle management (PLM) and the whole CP process. Fortunately, with the wide use of smart sensing devices in PLM, a large amount of real-time and multi-source lifecycle big data can now be collected. To make better PLM and CP decisions based on these data, in this paper, an overall architecture of big data-based analytics for product lifecycle (BDA-PL) was proposed. It integrated big data analytics and service-driven patterns that helped to overcome the above-mentioned barriers. Under the architecture, the availability and accessibility of data and knowledge related to the product were achieved. Focusing on manufacturing and maintenance process of the product lifecycle, and the key technologies were developed to implement the big data analytics. The presented architecture was demonstrated by an application scenario, and some observations and findings were discussed in details. The results showed that the proposed architecture benefited customers, manufacturers, environment and even all stages of PLM, and effectively promoted the implementation of CP. In addition, the managerial implications of the proposed architecture for four departments were analyzed and discussed. The new CP strategy provided a theoretical and practical basis for the sustainable development of manufacturing enterprises.

  • 31.
    Saifullah, Mohammad
    Linköping University, Department of Computer and Information Science. Linköping University, The Institute of Technology.
    A Biologically-Inspired Model for Recognition of Overlapped Patterns2011In: Proceedings International ICST Conference on Bio-Inspired Models of Network, Information and Computing Systems, 2011Conference paper (Refereed)
    Abstract [en]

    In this paper a biologically-inspired model for recognition of overlapped patterns is proposed. Information processing in the two visual information processing pathways, i.e., the dorsal and the ventral pathway, is modeled as a solution to the problem. We hypothesize that dorsal pathway, in addition to encoding the spatial information, learns the shape representation of the patterns and, later uses this knowledge as a top-down guidance signal to segment the bottom-up, image-based saliency map. This process of segmentation in the dorsal pathway is implemented as an interactive process, where interaction between bottom-up image information and top-down shape cues lead to incremental development of a segmented saliency map for one of the overlapped object at a time. This segmented map encodes spatial as well as shape information of the respective pattern in the input. The interaction of the dorsal channel with the ventral channel leads to modulation and selective processing of the respective pattern in the ventral pathway for final recognition. Simulation results support the presented hypothesis as well as effectiveness of the model in providing a solution to the recognition of overlapped patterns. The behavior of the model is in accordance to the known human behavior on the occluded patterns.

  • 32. Macoveanu, Julian
    et al.
    Klingberg, T.
    Tegnér, Jesper
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Computational Biology .
    A biophysical model of multiple-item working memory: A computational and neuroimaging study2006In: Neuroscience, ISSN 0306-4522, Vol. 141, no 3, 1611-1618 p.Article in journal (Refereed)
    Abstract [en]

    Biophysically based computational models have successfully accounted for the persistent neural activity underlying the maintenance of single items of information in working memory. The aim of the present study was to extend previous models in order to retain multiple items, in agreement with the observed human storage capacity. This was done by implementing cellular mechanisms known to occur during the childhood development of working memory, such as an increased synaptic strength and improved contrast and specificity of the neural response. Our computational study shows that these mechanisms are sufficient to create a neural network which can store information about multiple items through sustained neural activity. Furthermore, by using functional magnetic resonance imaging, we found that the information-activity curve predicted by the model corresponds to that in the human posterior parietal cortex during performance of working memory tasks, which is consistent with previous studies of brain activity related to working memory capacity in humans. © 2006 IBRO.

  • 33.
    Agnafors, Sara
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences.
    Svedin, Carl Göran
    Linköping University, Department of Clinical and Experimental Medicine, Barnafrid. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Child and Adolescent Psychiatry in Linköping.
    Oreland, Lars
    Uppsala University, Sweden.
    Bladh, Marie
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    Comasco, Erika
    Uppsala University, Sweden.
    Sydsjö, Gunilla
    Linköping University, Department of Clinical and Experimental Medicine, Division of Children's and Women's health. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
    A Biopsychosocial Approach to Risk and Resilience on Behavior in Children Followed from Birth to Age 122017In: Child Psychiatry and Human Development, ISSN 0009-398X, E-ISSN 1573-3327, Vol. 48, no 4, 584-596 p.Article in journal (Refereed)
    Abstract [en]

    An increasing prevalence of mental health problems calls for more knowledge into factors associated with resilience. The present study used multiple statistical methodologies to examine a biopsychosocial model of risk and resilience on preadolescence behavior. Data from 889 children and mothers from a birth cohort were used. An adversity score was created by combining maternal symptoms of depression, psychosocial risk and childrens experiences of life events. The proposed resilience factors investigated were candidate genetic polymorphisms, child temperament, social functioning, and maternal sense of coherence. The l/ l genotype of the serotonin transporter linked polymorphic region was associated with lower internalizing scores, but not mainly related to the level of adversity. An easy temperament was associated with resilience for children exposed to high adversity. Social functioning was found to be promotive independent of the risk level. The results support a multiple-level model of resilience indicating effects, though small, of both biological and psychosocial factors.

  • 34.
    Hasewinkel, Håkan
    Linköping University, Department of Computer and Information Science, MDALAB - Human Computer Interfaces. Linköping University, The Institute of Technology.
    A blueprint for using commercial games off the shelf in defence training, education and research simulations2006Licentiate thesis, monograph (Other academic)
    Abstract [en]

    There are two types of simulations, those made for business and those made for pleasure. The underlying technology is usually the same, the difference being how and for what purpose the simulation is used. Often the two purposes can be combined. Nowhere is this more obvious than in the mutual benefit that exists between the military community and the entertainment business. These mutual benefits have only in recent years begun to be seriously explored.

    The objective of this work is to explore how to modify and use commercial video games off the shelf, in defence training, education and research. The work focuses on the process of how and what to consider when modifying commercial off the shelf games for military needs.

    The outlined blueprint is based on studies performed with combatants from the Swedish Army. To facilitate the develop­ment of the blueprint, a great number of commercial games used by military communities around the world are evaluated. These evaluations, in harmony with literature in the area, are used to develop a basic theoretical framework. The basic theoretical framework characterizes the approach and style throughout the work.

    From a general point of view, there are two overall findings; first there is an urgent need for more intuitive, pedagogical and powerful tools for preparation, management and evaluation of game-based simulation, especially since the real learning often takes place during the modification process rather the during the playing session. Second, there is a defective understanding of the differences between and purposes of a defence simulation and a game. Defence simulations focus on actions and events, while video games focus on human reactions to actions and events. 

  • 35.
    Edström, Kristina
    et al.
    School of Education and Communication in Engineering Science, KTH Royal Institute of Technology, Stockholm, Sweden.
    Kolmos, Anette
    Department of Development and Planning, Aalborg University, Aalborg, Denmark.
    Malmi, Lauri
    Department of Computer Science, Aalto University, Helsinki, Finland.
    Bernhard, Jonte
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Andersson, Pernille
    LearningLab DTU, Technical University of Denmark, Kgs. Lyngby, Denmark.
    A bottom-up strategy for establishment of EER in three Nordic countries: The role of networks2016In: European Journal of Engineering Education, ISSN 0304-3797, E-ISSN 1469-5898Article in journal (Refereed)
    Abstract [en]

    This paper investigates the emergence of an engineering education research (EER) community in three Nordic countries: Denmark, Finland and Sweden. First, an overview of the current state of Nordic EER authorship is produced through statistics on international publication. Then, the history of EER and its precursor activities is described in three national narratives. These national storylines are tied together in a description of recent networking activities, aiming to strengthen the EER communities on the Nordic level. Taking these three perspectives together, and drawing on concepts from community of practice theory, network theory and learning network theory, we discuss factors behind the differences in the countries, and draw some conclusions about implications for networking activities in a heterogeneous community. Further, we discuss the role of networks for affording a joint identity.

  • 36.
    Witell, Lars
    et al.
    Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Gebauer, Heiko
    EAWAG, Switzerland.
    Jaakkola, Elina
    Turku School of Economics, University of Turku, Finland.
    Hammedi, Wafa
    University of Namur, Belgium.
    Patricio, Lia
    Faculty of Engineering, University of Porto, Portugal.
    Perks, Helen
    University of Nottingham, UK.
    A bricolage perspective on service innovation2017In: Journal of Business Research, ISSN 0148-2963, E-ISSN 1873-7978, Vol. 79, 290-298 p.Article in journal (Refereed)
    Abstract [en]

    Service innovation is often viewed as a process of accessing the necessary resources, (re)combining them, and converting them into new services. The current knowledge on success factors for service innovation, such as formalized new service development (NSD) processes, predominantly comes from studying large firms with a relatively stable resource base. However, this neglect situations in which organizations face severe resource constraints. This paper argues that under such constraints, a formalized new service development process could be counter-productive and a bricolage perspective might better explain service innovation in resource-constrained environments. In this conceptual paper, we propose that four critical bricolage capabilities (addressing resource scarcity actively, making do with what is available, improvising when recombining resources, and networking with external partners) influence service innovation outcomes. Empirical illustrations from five organizations substantiate our conceptual development. Our discussion leads to a framework and four testable propositions that can guide further service research.

    The full text will be freely available from 2020-04-01 13:45
  • 37.
    Hallander, Ingrid
    Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems. Linköping University, The Institute of Technology.
    A broad perspective on life cycle considerations in product development2004Licentiate thesis, comprehensive summary (Other academic)
    Abstract [en]

    For products with long life cycles, operational and support costs represent a significant part of the total cost for the product. Moreover, such products frequently tend to be complex and contain a mixture of both mature. stable technology with bng life cycles and new technology with short life cycles. lt is therefore of great interest to industry to determine how to take these factors into consideration in an efficient way during product development.

    Another factor that affects product development for these and other kinds of products with shorter life cycles is interest in taking a wider view of the end-user or customer scenario, for instance by offering support and after sales services for the products. All these interests drive the demand to consider life cycle related issues in product development, not just life cycle cost. This also makes a life cycle perspective interesting for fums that produce products with shorter life cycles than the ones studied here through the opportunity for after market sales and services.

    This research has been explorative, aiming to understand how firms manage to take life cycle related demands into consideration during product development. The aim was to expand from a cost oriented focus to a wider focus, a value oriented focus, here called life cycle value. The dominant question has been "how" life cycle related demands are considered, focusing on barriers to and enablers for this. Equally important has been to determine the implication of life cycle value for different firms and industries and to find out where value is added in product development. A combination of a quantitative and qualitative research approach has been used to collect empirical data.

    One important finding was that there is an interest to deliver a solution to the customer rather than just a product, to consider customer revenue. This adds a new perspective to the implication of life cycle value, moving from a life cycle cost scenario to a life cycle cost versus revenue scenario. The results fom cases were categorized into six main attributes. These attributes were considered to be very influential and important for the ability to take life cycle perspective into account during product development.

    • Holistic Perspective
    • Requirements & Metrics
    • Leadership & Management/Knowledge management
    • Tools & Methods
    • Organizational Factors
    • Enterprise Relationships

    Within each of these attributes, several practices and lessons learned were identified. Some of the results are also worth investigating further in continued research:

    • Requirements formulation and management is considered to be critical. Well defined and clearly stated demands are key to taking life cycle issues into account due to the difficulty of incorporating life cycle related demands into the product. Nonetheless, balancing these demands against others is perceived to be difficult, and there is a clear need for tools, methods or models to support decision-making in this context.
    • The incorporation of new technology and services is another field of interest to industry. Organizational support and planning for technology insertion and new innovations and services into existing products and product lines are needed.
    • The organizational support to balance specialization and integration in a product development context, with a long-term focus
    • The effect of a transfer from delivering a product to delivering product and support services to the organization.
    List of papers
    1. Life cycle value in product development: a case study in the transportation industry
    Open this publication in new window or tab >>Life cycle value in product development: a case study in the transportation industry
    2003 (English)In: DS 31: Proceedings of ICED 03, the 14th International Conference on Engineering Design, Stockholm, Stockholm, Sweden: ICED'03 , 2003, 417-418 p.Conference paper, Published paper (Other academic)
    Abstract [en]

    Several factors prevent enterprises from having a holistic perspective during product development. Important aspects include increased product complexity and significant uncertainty with regard to technology. For products with a long life cycle this is extremely important since development and life cycle costs are high. The combination of complexity of system design and the limits of individual human comprehension typically make it difficult to envision a best value solution.

    In an attempt to encircle a more holistic perspective of value, the concept of Life Cycle Value has evolved within the Lean Aerospace Initiative, LAI. The implication of this is development of products incorporating life cycle and long-term focus including cost and performance and reliability factors. A similar perspective has evolved within the Lean Aircraft Research Program, LARP, in Sweden.

    This paper contributes a new study of how life cycle aspects are taken into consideration in a large corporation in the transportation industry. The purpose of the research was to examine relative contributions to product development and determine factors that significantly promote the ability to consider the life cycle perspective. The results will be discussed with respect to tools, methods, requirements, metrics, leadership and other organizational factors, innovation, and enterprise relationships.

    Place, publisher, year, edition, pages
    Stockholm, Sweden: ICED'03, 2003
    Keyword
    Life cycle, value, product development, transportation industry
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-36398 (URN)31246 (Local ID)1-904670-00-8 (ISBN)31246 (Archive number)31246 (OAI)
    Conference
    ICED 03, the 14th International Conference on Engineering Design, Stockholm
    Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2013-12-03
    2. Lifecycle value framework for tactical aircraft product development
    Open this publication in new window or tab >>Lifecycle value framework for tactical aircraft product development
    2001 (English)Conference paper, Published paper (Other academic)
    Abstract [en]

    Due to a dramatic reduction in defense procurement, the benchmark for developing new defense systems today is performance at an affordable cost. In an attempt to encircle a more holistic perspective of value, lifecycle value has evolved as a concept within the Lean Aerospace Initiative, LAI. The implication of this is development of products incorporating lifecycle and long-term focus instead of a shortsighted cost cutting focus. The interest to reduce total cost of ownership while still improving performance, availability, and sustainability, other dimensions taken into account within the lifecycle value approach, falls well within this context. Several factors prevent enterprises from having a holistic perspective during product development. Some important aspects are increased complexity of the products and significant technological uncertainty. The combination of complexity in system design and the limits of individual human comprehension typically prevent a best value solution to be envisioned. The purpose of this research was to examine relative contributions in product development and determine factors that significantly promote abilities to consider and achieve lifecycle value. This paper contributes a maturity matrix based on important practices and lessons learned through extensive interview based case studies of three tactical aircraft programs, including experiences from more than 100 interviews.

    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-102199 (URN)
    Conference
    2001 Eleventh Annual International Symposium, Melbourne, Australia, 1-5 July 2001
    Available from: 2013-12-03 Created: 2013-12-03 Last updated: 2013-12-03
  • 38.
    Brenning, Nils
    et al.
    Royal Institute of Technology, Stockholm.
    Axnas, I
    Royal Institute of Technology, Stockholm.
    Raadu, M. A.
    Royal Institute of Technology, Stockholm.
    Lundin, Daniel
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Helmersson , Ulf
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Plasma and Coating Physics .
    A bulk plasma model for dc and HiPIMS magnetrons2008In: PLASMA SOURCES SCIENCE and TECHNOLOGY, ISSN 0963-0252 , Vol. 17, no 4, 045009- p.Article in journal (Refereed)
    Abstract [en]

    A plasma discharge model has been developed for the bulk plasma (also called the extended presheath) in sputtering magnetrons. It can be used both for high power impulse magnetron sputtering (HiPIMS) and conventional dc sputtering magnetrons. Demonstration calculations are made for the parameters of the HiPIMS sputtering magnetron at Link "oping University, and also benchmarked against results in the literature on dc magnetrons. New insight is obtained regarding the structure and time development of the currents, the electric fields and the potential profiles. The transverse resistivity eta(perpendicular to) has been identified as having fundamental importance both for the potential profiles and for the motion of ionized target material through the bulk plasma. New findings are that in the HiPIMS mode, as a consequence of a high value of eta(perpendicular to), (1) there can be an electric field reversal that in our case extends 0.01-0.04m from the target, (2) the electric field in the bulk plasma is typically an order of magnitude weaker than in dc magnetrons, (3) in the region of electric field reversal the azimuthal current is diamagnetic in nature, i.e. mainly driven by the electron pressure gradient, and actually somewhat reduced by the electron Hall current which here has a reversed direction and (4) the azimuthal current above the racetrack can, through resistive friction, significantly influence the motion of the ionized fraction of the sputtered material and deflect it sideways, away from the target and towards the walls of the magnetron.

  • 39.
    Fahlgren, Anna
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine.
    Chubinskaya, S
    Messner, Karola
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    Aspenberg, Per
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    A capsular incision leads to a fast osteoarthritic response, but also elevated levels of activated osteogenic protein-1 in rabbit knee joint cartilage2006In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, Vol. 16, no 6, 456-462 p.Article in journal (Refereed)
    Abstract [en]

    We studied whether a small capsular incision alone, or combined with meniscectomy could induce early osteoarthritic changes in the rabbit knee. Thirty-one rabbits were operated on with a capsular incision in the left knee and meniscectomy in the right knee. Another 12 rabbits were used as controls. The rabbits were killed 3, 6 and 12 weeks after surgery. Osteoarthritic changes in the articular cartilage were evaluated by the modified Mankin score. The subchondral bone was evaluated by scintimetry (99mTc-HDP) and semiquantitative grading of histological changes. Osteogenic protein (OP-1) in its mature and pro-form was examined by immunohistochemistry. Both a capsular incision and meniscectomy induced articular cartilage fibrillation and increased bone metabolic activity during the initial weeks after surgery. Capsular incision led to lesser changes than meniscectomy. Mature OP-1 was elevated, and its pro-form reduced, in meniscectomized knees. A similar pattern was observed in knees with capsular incision. Already 3 weeks after surgery, the articular cartilage and subchondral bone showed typical signs of early osteoarthritis (OA), and a reparative response was suggested by increased intensity of OP-1 staining. As these signs were also found in knees with capsular incision only, it appears that trauma-related factors such as increased bleeding and inflammation are critical for the development of OA. Copyright © Blackwell Munksgaard 2006.

  • 40.
    Osvaldsson, Karin
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Social and Welfare Studies, Social Work.
    A case for dialogue between studies of interaction and psychoanalysis in child development.2017In: Research on Children and Social interaction, ISSN ISSN 2057-5807 (print)Article, book review (Other academic)
  • 41.
    Luksaite, Arune
    Linköping University, Department of Management and Economics.
    A Case for International Socialisation: the Development of the National Role Conceptions of Latvia, Estonia and Lithuania in the Baltic Sea Region.2003Independent thesis Advanced level (degree of Magister)Student thesis
    Abstract [en]

    When the Baltic States declared their independence in 1991, they did not become equal members of the international community in one day. Although the fall of the Berlin wall and the collapse of the Soviet Union declared the end to the Cold War, ideas, beliefs, prejudices and discourses were much harder to trigger. The study addresses the issues of newly independent states, establishing themselves in the international community, analysing the processes of learning in the interaction with the other international actors. By combining Role theory and Constructivism the author develops a framework to understand the development and change of Baltic States role conceptions. How have Baltic states perceived their role in the Baltic Sea region during the period 1993-2002? How has the western discourse treated them? What role did the application for the EU membership play in the process? What have been the individual and group features of the Baltic States? The study attempts to answer these and other questions through thediscourse analysis of public speeches.

  • 42.
    Patel, Mikael
    et al.
    Ericsson AB, Linköping, Sweden.
    Borg, Andreas
    Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory. Linköping University, The Institute of Technology.
    Sandahl, Kristian
    Linköping University, Department of Computer and Information Science. Linköping University, Department of Computer and Information Science, PELAB - Programming Environment Laboratory.
    A Case Study in Assessing and Improving Capacity Using an Anatomy of Good Practice2007In: The 6th joint meeting of the European Software Engineering Conference and the ACM SIGSOFT Symposium on the Foundations of Software Engineering (ESEC/FSE 2007), Dubrovnik, Croatia, New York: ACM , 2007, 509-512 p.Conference paper (Refereed)
    Abstract [en]

    Capacity in telecommunication systems is highly related to operator revenue. As a vendor of such systems, Ericsson AB is continuously improving its processes for estimating, specifying, tuning, and testing the capacity of delivered systems. In order to systematize process improvements Ericsson AB and Linköping University joined forces to create an anatomy of Capacity Sub Processes (CSPs). The anatomy is the result of an interview series conducted to document good practices amongst organizations active in capacity improvement. In this paper we analyze four different development processes in terms of how far they have reached in their process maturity according to our anatomy and show possible improvement directions. Three of the processes are currently in use at Ericsson, and the fourth is the OpenUP/Basic process which we have used as a reference process in earlier research. We also include an analysis of the observed good practices. The result mainly confirms the order of CSPs in the anatomy, but we need to use our information of the maturity of products and the major life cycle in the organization in order to fully explain the role of the anatomy in planning of improvements.

  • 43.
    Woltjer, Rogier
    et al.
    Linköping University, Department of Computer and Information Science, CSE - Cognitive Systems Engineering Laboratory. Linköping University, The Institute of Technology.
    Lindgren, Ida
    Linköping University, Department of Management and Engineering, Industrial ergonomics . Linköping University, The Institute of Technology.
    Smith, Kip
    Linköping University, Department of Management and Engineering, Industrial ergonomics . Linköping University, The Institute of Technology.
    A case study of information and communication technology in emergency management training2006In: International Journal of Emergency Management, ISSN 1471-4825, Vol. 3, no 4, 332-347 p.Article in journal (Refereed)
    Abstract [en]

    This paper addresses the roles of Information and Communication Technology (ICT) in training for effective emergency management and inter-organisational coordination. Collocation can encourage the development of common ground and trust and, in turn, result in greater efficiency and effectiveness. We expect to find communication and artefact use during collocated training that cannot readily transfer to the ICT used to link distributed work settings. This expectation makes the reliance on ICT and distributed work during emergency management operations suspect. To test these claims, we observed a large-scale, real-time exercise designed to facilitate cooperation among electricity and telecommunications companies. The exercise scenario was similar to the January 2005 windstorm that left much of southern Sweden without electricity or telephone service and revealed the need for better cooperation among utility providers. The observations suggest that while collocation is clearly beneficial, a mismatch in ICT use between collocated training and distributed emergency management operations is likely to be detrimental for preparedness.

  • 44.
    Höst, Gunnar E.
    et al.
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, The Institute of Technology.
    Schönborn, Konrad J.
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, The Institute of Technology.
    Lundin Palmerius, Karljohan
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, The Institute of Technology.
    A Case-Based Study of Students' Visuohaptic Experiences of Electric Fields around Molecules: Shaping the Development of Virtual Nanoscience Learning Environments2013In: Education Research International, ISSN 2090-4002, E-ISSN 2090-4010, Vol. 2013, 194363Article in journal (Refereed)
    Abstract [en]

    Recent educational research has suggested that immersive multisensory virtual environments offer learners unique and exciting knowledge-building opportunities for the construction of scientific knowledge. This paper delivers a case-based study of students’ immersive interaction with electric fields around molecules in a multisensory visuohaptic virtual environment. The virtual architecture presented here also has conceptual connections to the flourishing quest in contemporary literature for the pressing need to communicate nanoscientific ideas to learners. Five upper secondary school students’ prior conceptual understanding of electric fields and their application of this knowledge to molecular contexts, were probed prior to exposure to the virtual model. Subsequently, four students interacted with the visuohaptic model while performing think-aloud tasks. An inductive and heuristic treatment of videotaped verbal and behavioural data revealed distinct interrelationships between students’ interactive strategies implemented when executing tasks in the virtual system and the nature of their conceptual knowledge deployed. The obtained qualitative case study evidence could serve as an empirical basis for informing the rendering and communication of overarching nanoscale ideas. At the time of composing this paper for publication in the current journal, the research findings of this study have been put into motion in informing a broader project goal of developing educational virtual environments for depicting nanophenomena.

  • 45. Faresjö, Åshild
    et al.
    Grodzinsky, Ewa
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Department of Health and Society, General Practice. Östergötlands Läns Landsting, Local Health Care Services in the West of Östergötland, Unit of Research and Development in Local Health Care, County of Östergötland.
    Timpka, Toomas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Department of Health and Society, Division of Preventive and Social Medicine and Public Health Science. Östergötlands Läns Landsting, Centre for Public Health Sciences, Centre for Public Health Sciences.
    Åkerlind, Ingemar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Department of Health and Society, National Centre for Work and Rehabilitation. Östergötlands Läns Landsting, Local Health Care Services in the West of Östergötland, Unit of Research and Development in Local Health Care, County of Östergötland.
    A case-control study of irritable bowel syndrome in primary care - female patients are seriously affected by psychosocial problems in their every day life2006In: EUPHA 14th annual conference,2006, 2006Conference paper (Other academic)
  • 46.
    Byers, David
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Computer and Information Science, Database and information techniques.
    Shahmehri, Nahid
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    A Cause-Based Approach to Preventing Software Vulnerabilities2008In: Third International Conference on Availability, Reliability and Security, 2008, IEEE Computer Society, 2008, 276-283 p.Conference paper (Refereed)
    Abstract [en]

    Security is often an afterthought in software development, sometimes even bolted on during deployment or in maintenance through add-on security software and penetrate-and-patch maintenance. We think that security needs to be an integral part of software development and that preventing vulnerabilities by addressing their causes is as important as detecting and fixing them. In this paper we present a method for determining how to prevent vulnerabilities from being introduced during software development. Our method allows developers to select the set of activities that suits them best while being assured that those activities will prevent vulnerabilities. Our method is based on formal modeling of vulnerability causes and is independent of the software development process being used.

  • 47.
    Andriolo, Alessandro
    et al.
    University of Padova, Italy.
    Battini, Dania
    University of Padova, Italy.
    Grubbström, Robert W.
    Linköping University, Department of Management and Engineering, Production Economics. Linköping University, The Institute of Technology.
    Persona, Alessandro
    University of Padova, Italy.
    Sgarbossa, Fabio
    University of Padova, Italy.
    A century of evolution from Harriss basic lot size model: Survey and research agenda2014In: International Journal of Production Economics, ISSN 0925-5273, Vol. 155, 16-38 p.Article in journal (Refereed)
    Abstract [en]

    Determining the economic lot size has always represented one of the most important issues in production planning. This problem has long attracted the attention of researchers, and several models have been developed to meet requirements at minimum cost. In this paper we explore and discuss the evolution of these models during one hundred years of history, starting from the basic model developed by Harris in 1913, up to today. Following Harriss work, a number of researchers have devised extensions that incorporate additional considerations. The evolution of EOQ theory strongly reflects the development of industrial systems over the past century. Here we outline all the research areas faced in the past by conducting a holistic analysis of 219 selected journal papers and trying to give a comprehensive view of past work on the EOQ problem. Finally, a new research agenda is proposed and discussed.

  • 48.
    Pham, M K
    et al.
    IAEA.
    Betti, M
    IAEA.
    Povinec, P P
    Comenius University.
    Benmansour, M
    Centre Natl Energie Science and Tech Nucl, Rabat.
    Buenger, V
    Senatsverwaltung Gesundheit Umwelt and Verbraucher.
    Drefvelin, J
    Norwegian Radiation Protection Authority.
    Engeler, C
    WGMLA Radiochem.
    Flemal, J M
    Science Institute for Public Health.
    Gasco, C
    Centre Invest Energet MedioAmbient and Technology.
    Guillevic, J
    Institute Radioprotect and Surette Nucl.
    Gurriaran, R
    IRSN DEI STEME LMRE.
    Groening, M
    IAEA.
    Happel, J D
    University of Miami.
    Herrmann, J
    Bundesamt Seeschifffahrt and Hydrog.
    Klemola, S
    Radiat and Nucl Safety Author.
    Kloster, M
    Senatsverwaltung Gesundheit Umwelt and Verbraucher.
    Kanisch, G
    Johann Heinrich von Thunen Institute.
    Leonard, K
    Centre Environm Fisheries and Aquaculture Science.
    Long, S
    Radiol Protect Institute Ireland.
    Nielsen, S
    Riso Natl Lab.
    Oh, J-S
    Natl Oceanog Centre Southampton.
    Rieth, P U
    Johann Heinrich von Thunen Institute.
    Oestergren, I
    Swedish Radiat Safety Author.
    Pettersson, Håkan
    Linköping University, Department of Medical and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics.
    Pinhao, N
    Institute Tecnol and Nucl, Sacavem, Portugal .
    Pujol, L
    Centre Estudios Expt and Obras Publ.
    Sato, K
    Japan Chemistry Anal Centre.
    Schikowski, J
    University of Gottingen.
    Varga, Z
    Hungarian Academy of Science.
    P Vartti, V
    Radiat and Nucl Safety Author.
    Zheng, J
    Natl Institute Radiol Science.
    A certified reference material for radionuclides in the water sample from Irish Sea (IAEA-443)2011In: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, ISSN 0236-5731, Vol. 288, no 2, 603-611 p.Article in journal (Refereed)
    Abstract [en]

    A new certified reference material (CRM) for radionuclides in sea water from the Irish sea (IAEA-443) is described and the results of the certification process are presented. Ten radionuclides (H-3, K-40, Sr-90, Cs-137, U-234, U-235, U-238, Pu-238, Pu239+240 and Am-241) have been certified, and information values on massic activities with 95% confidence intervals are given for four radionuclides (Th-230, Th-232, Pu-239 and Pu-240). Results for less frequently reported radionuclides (Tc-99, Th-228, Np-237 and Pu-241) are also reported. The CRM can be used for quality assurance/quality control of the analysis of radionuclides in water samples, for the development and validation of analytical methods and for training purposes. The material is available in 5 L units from IAEA (http://nucleus.iaea.org/rpst/index.htm).

  • 49.
    Fägerskiöld, Astrid
    Linköping University, Department of Medical and Health Sciences, Nursing Science. Linköping University, Faculty of Health Sciences.
    A change in life as experienced by first-time fathers2008In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 22, no 1, 64-71 p.Article in journal (Refereed)
    Abstract [en]

    Research suggests that the attitude of men towards pregnancy, childbirth and child-caring is different from that of women. Up to now, research has focused mainly on motherhood. The aim of this study was to explore first-time fathers’ experiences during early infancy of their children. Grounded theory and constant comparative method were used and 20 fathers aged 20–48 participated. Interviews were carried out in 2002–2003. ‘Changing life’ emerged as the core category consisting of the categories: becoming a father, alternating between work and home, changing relationship towards partner and developing relationship with their child. Changing life implied that they have left bachelor life and become responsible for a child. Becoming a father was much more fantastic than they could have imagined and they suggested that they performed childcare to the same extent as the mother when both parents were at home. Still fathers viewed the mother as the main parent, partly because of their alternating between work and home and because the mothers breast-feed the infants. Fathers’ attitude towards breast-feeding seemed to be ambiguous; it was a matter of necessity, but made them feel insignificant. Changing relationship towards partner was common but it was not necessarily for the worst and often resulted in a more closely united relationship. However, tiredness because of lack of sleep could result in increased irritability towards problems. Developing relationship with their child implied increasing possibilities to learn to know the infant’s signals. Fathers are one of two parents, and hence are important for their child’s growth and development, emotional health and cognitive development. Knowledge about first-time fathers’ experiences during the early infancy of their children may bring about increased support from midwives and child health nurses.

  • 50.
    Malm, Anna
    et al.
    Linköping University, Department of Management and Engineering, Manufacturing Engineering. Linköping University, Faculty of Science & Engineering. Saab Group, Business Area Aeronautics, Linköping, Sweden.
    Andersson, Henric
    Saab Group, Business Area Aeronautics, Linköping, Sweden.
    A change process: transition from 2D to 3D by Model Based Definition2014In: Proceedings of the 6th Swedish Production Symposium (SPS), Gothenburg, Sweden. September 2014, 2014, 1-10 p.Conference paper (Other academic)
    Abstract [en]

    The purpose of the study is to investigate factors that are important for the transition from 2D to 3D by Model Based Definition (MBD). Within MBD, 3D models are used as sources of information for design, production, distribution, technical documentation, services and the overall product lifecycle. The introduction and development of MBD at Aeronautics can be described in five transitions that illustrate how knowledge enhancement from project to project and between the projects and the linear organization has evolved. The largest challenges have been in the start-up of the transitions, people are gathered with different prerequisites, seeing solutions or problems from different perspectives.

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