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  • 1.
    Graham, A.C.
    et al.
    Cavendish Laboratory, Madingley Road, Cambridge CB3 OHE, United Kingdom.
    Thomas, K.J.
    Cavendish Laboratory, Madingley Road, Cambridge CB3 OHE, United Kingdom.
    Pepper, M.
    Cavendish Laboratory, Madingley Road, Cambridge CB3 OHE, United Kingdom.
    Simmons, M.Y.
    Cavendish Laboratory, Madingley Road, Cambridge CB3 OHE, United Kingdom, School of Physics, University of New South Wales, Sydney, NSW 2052, Australia.
    Ritchie, D.A.
    Cavendish Laboratory, Madingley Road, Cambridge CB3 OHE, United Kingdom.
    Berggren, Karl-Fredrik
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics .
    Jaksch, Peter
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics .
    Debnarova, Andrea
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Yakimenko, I.I.
    0.7 Analogue structures and exchange interactions in quantum wires2004In: Solid State Communications, ISSN 0038-1098, Vol. 131, no 9-10 SPEC. ISS., 591-597 p.Article in journal (Refereed)
    Abstract [en]

    We present experimental studies of crossings of spin-split one-dimensional subbands in ballistic quantum wires in an in-plane magnetic field B ?. At low electron densities, a spontaneous spin-splitting occurs as subbands cross, which gives rise to additional non-quantised conductance structures called 0.7 analogues. We analyse the data within a spin-density-functional model, which includes exchange interactions in a magnetic field. Focussing on the region of the crossings of spin-split subbands, it is found that the energy levels rearrange as they cross due to exchange interactions. © 2004 Elsevier Ltd. All rights reserved.

  • 2.
    Hassan Raza Naqvi, Syed
    Linköping University, Department of Electrical Engineering.
    1 GS/s, Low Power Flash, Analog to Digital Converter in 90nm CMOS Technology2007Independent thesis Advanced level (degree of Magister), 20 points / 30 hpStudent thesis
    Abstract [en]

    The analog to digital converters is the key components in modern electronic systems. As the digital signal processing industry grows the ADC design becomes more and more challenging for researchers. In these days an ADC becomes a part of the system on chip instead of standalone circuit for data converters. This increases the requirements on ADC design concerning for example speed, power, area, resolution, noise etc. New techniques and methods are going to develop day by day to achieve high performance ADCs.

    Of all types of ADCs the flash ADC is not only famous for its data conversion rate but also it becomes the part of other types of ADC for example pipeline and multi bit Sigma Delta ADCs. The main problem with a flash ADC is its power consumption, which increases in number of bits. This thesis presents the comparison of power consumption of different blocks in 1Gbps flash ADCs for 2, 4 and 6 bits in a 90nm CMOS technology. We also investigate the impact on power consumption by changing the design of decoder block.

  • 3.
    Chen, Miaoxiang
    et al.
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Perzon, Erik
    Materials and Surface Chemistry, Chalmers University of Technology, Göteborg, Sweden .
    Andersson, Mats R.
    Materials and Surface Chemistry, Chalmers University of Technology, Göteborg, Sweden .
    Marcinkevicius, Saulius
    Department of Microelectronics and Information Technology, Royal Institute of Technology, Kista, Sweden .
    Jönsson, Stina
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Fahlman, Mats
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Berggren, Magnus
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    1 micron wavelength photo- and electroluminescence from a conjugated polymer2004In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 84, no 18, 3570-3572 p.Article in journal (Refereed)
    Abstract [en]

    We report photo- and electroluminescence from an alternating conjugated polymer consisting of fluorene units and low-band gap donor-acceptor-donor (D–A–D) units. The D–A–D segment includes two electron-donating thiophene rings combined with a thiadiazolo-quinoxaline unit, which is electron withdrawing to its nature. The resulting polymer is conjugated and has a band gap of 1.27 eV. The corresponding electro- and photoluminescence spectra both peak at approximately 1 μm. Light-emitting diodes, based on a single layer of the polymer, demonstrated external quantum efficiencies from 0.03% to 0.05%.

  • 4.
    Chen, J.
    et al.
    Ericsson Research.
    Ze, H.
    Chalmers University of Technology.
    Bao, L.
    Ericsson Research.
    Svensson, Christer
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Li, Y.
    Ericsson Research.
    Gunnarsson, S.
    SiversIMA AB.
    Stoij, C.
    SiversIMA AB.
    Zirath, H.
    Chalmers University of Technology.
    10 Gbps 16QAM Transmission over a 70/80 GHz (E-band) Radio Test-bed2012In: 2012 7th European Microwave Integrated Circuit Conference, IEEE , 2012, 556-559 p.Conference paper (Refereed)
    Abstract [en]

    A millimeter-wave radio test-bed is implemented which demonstrates 16QAM transmission over 70/80 GHz band for data rate up to 10 Gbps. Performance of the 16QAM transmitter and receiver is evaluated in a loop-back lab set-up. With the proposed 10 Gbps on single carrier system architecture, it is possible to achieve 40 Gbps over a 5 GHz bandwidth when combined with polarization and spatial multiplexing.

  • 5.
    Andersson, Stefan
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Electrical Engineering, Electronic Devices.
    Svensson, Christer
    Linköping University, The Institute of Technology. Linköping University, Department of Electrical Engineering, Electronic Devices.
    10 GHz wideband low-noise amplifier using a 0,35um SiGe BiCMOS technology.2002In: SSoCC´02 confernce,2002, 2002Conference paper (Refereed)
  • 6.
    Lindström, Stefan B
    et al.
    Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, Faculty of Science & Engineering.
    Thore, Carl-Johan
    Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, Faculty of Science & Engineering.
    10000 mechanics problems at the press of a button2015In: Proceedings of Svenska Mekanikdagar, Linköping University, 2015, 84- p.Conference paper (Other academic)
    Abstract [en]

    Problem solving is at the heart of the mechanics curriculum, and developing problem solving skills is an important learning objective in basic and advanced mechanics courses at the undergraduate level. In alignment with this tradition, written examinations are mainly designed to test problem solving capabilities. Despite the fact that students spend most of their mechanics studies solving mechanics problems, an alarming fraction of them fail the written examination. One possible explanation is that a problem solving infrastructure, e.g. answers to problems and opportunities for collaboration with fellow students, is provided during the study period of courses, but missing during the examination.

  • 7.
    Bigault, Thierry
    et al.
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Birch, Jens
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Buffet, J. C.
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Correa, Jonathan
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Hall-Wilton, Richard
    European Spallation Source ESS AB, Lund, Sweden.
    Hultman, Lars
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Höglund, Carina
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Guérard, Bruno
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Khaplanov, Anton
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Piscitelli, Fransesco
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    van Esch, P.
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    10B multi-grid proportional gas counters for large area thermal neutron detectors2012In: Neutron News, ISSN 1044-8632, Vol. 23, no 4, 20-24 p.Article in journal (Refereed)
  • 8.
    Andersen, Ken
    et al.
    European Spallation Source ESS AB, Lund, Sweden.
    Bigault, Thierry
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Birch, Jens
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Buffet, J. C.
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Correa, Jonathan
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Hall-Wilton, Richard
    European Spallation Source ESS AB, Lund, Sweden.
    Hultman, Lars
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Höglund, Carina
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Guerard, Bruno
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Jensen, Jens
    Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics. Linköping University, The Institute of Technology.
    Khaplanov, Anton
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Kirstein, Oliver
    Linköping University.
    Piscitelli, Fransesco
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    van Esch, P.
    Institut Laue Langevin, Grenoble, Cedex 9, France.
    Vettier, Christian
    European Spallation Source, Lund, Sweden.
    10B multi-grid proportional gas counters for large area thermal neutrondetectors2013In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, ISSN 0168-9002, Vol. 720, 116-121 p.Article in journal (Refereed)
    Abstract [en]

    3He was a popular material in neutrons detectors until its availability dropped drastically in 2008. The development of techniques based on alternative convertors is now of high priority for neutron research institutes. Thin films of 10B or 10B4C have been used in gas proportional counters to detect neutrons, but until now, only for small or medium sensitive area. We present here the multi-grid design, introduced at the ILL and developed in collaboration with ESS for LAN (large area neutron) detectors. Typically thirty 10B4C films of 1 μm thickness are used to convert neutrons into ionizing particles which are subsequently detected in a proportional gas counter. The principle and the fabrication of the multi-grid are described and some preliminary results obtained with a prototype of 200 cm×8 cm are reported; a detection efficiency of 48% has been measured at 2.5 Å with a monochromatic neutron beam line, showing the good potential of this new technique.

  • 9.
    Li, Jia
    Linköping University, Department of Electrical Engineering.
    10G GPON Management System Study and Implementation2009Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This thesis includes the GPON management system concept study and implementation work to translate the command line interface management mechanism to a user friendly GUI (graphic user interface). The original system was developed in C program with a client-server structure. The new system retains the same communication structure and protocol interface between the OLT PON card and user workstations. On the workstation side, a new GUI management client application is developed in Java to offer the similar functionalities as the original one, and a totally new graphic real-time system traffic statistics function is integrated to make it easier for user to monitor system traffic information in real time.

     

    The main object of this project is to study the GPON specifications, and understand GPON system working procedure and traffic transmission principle. On the other hand, ‘original system management application’ study is necessary including third party documentation reading and C code understanding. This study has resulted in the development of a new application in Java with third party user libraries and plug-ins. This new application has been tested using basic function tests executed in the GPON lab environment.

  • 10.
    Dahlgaard Park, Su Mi
    et al.
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Management and Economics, Business Administration.
    Dahlgaard, Jens Jörn
    Linköping University, The Institute of Technology. Linköping University, Department of Management and Engineering, Quality Technology and Management .
    10th QMOD Conference. Quality Management and Organizationel Development. Our Dreams of Excellence2008Report (Other academic)
  • 11.
    Nilsson, Sara
    et al.
    Linköping University, Department of Management and Engineering, Manufacturing Engineering. Linköping University, Faculty of Science & Engineering.
    Jensen, Jonas
    Linköping University.
    Björkman, Mats
    Linköping University, Department of Management and Engineering, Manufacturing Engineering. Linköping University, Faculty of Science & Engineering.
    Sundin, Erik
    Linköping University, Department of Management and Engineering, Manufacturing Engineering. Linköping University, Faculty of Science & Engineering.
    11 Rules of Design for Manufacturing when Producing Pre-Impregnated Carbon Fiber-Reinforced Plastic Components: an Application at SAAB Aerostructures2016In: SAE Technical Papers, Society of Automotive Engineers, 2016, 1-8 p., 2016-01-2124Conference paper (Refereed)
    Abstract [en]

    Carbon ber-reinforced plastic (CFRP) is one of the most commonly used materials in the aerospace industry today. CFRP in pre- impregnated form is an anisotropic material whose properties can be controlled to a high level by the designer. Sometimes, these properties make the material hard to predict with regards to how the geometry affects manufacturing aspects. This paper describes eleven design rules originating from different guidelines that describe geometrical design choices and deals with manufacturability problems that are connected to them, why they are connected and how they can be minimized or avoided. Examples of design choices dealt with in the rules include double curvature shapes, assembly of uncured CFRP components and access for non-destructive testing (NDT). To verify the technical content and ensure practicability, the rules were developed by, inter alia, studying literature and performing case studies at SAAB Aerostructures. The research was done through a collaboration between Linköping University and SAAB Aerostructures in a state-funded project. This ensured a balanced approach between academic advancement and usefulness in commercial projects. 

  • 12.
    Levi, Richard
    et al.
    Karolinska Institute, Sweden.
    Carlberg, Lena
    Träff, Catrine
    Råsten, Malin
    West, Staffan
    115 frågor och svar om MS: Rehab Station Stockholm2007Book (Other academic)
    Abstract [en]

    n/a

  • 13.
    Nordeman, Patrik
    et al.
    Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
    Johansson, Leif B. G.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Bäck, Marcus
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Estrada, Sergio
    Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden..
    Hall, Håkan
    Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden..
    Sjölander, Daniel
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Westermark, Gunilla T.
    Department of Medicinal Cell Biology, Uppsala University, Uppsala, Sweden.
    Westermark, Per
    Department of Immunology, Genetics and Pathology, Uppsala University, UppsalaSweden.
    Nilsson, Lars
    Department of Pharmacology, University of Oslo, Oslo, Norway.
    Hammarström, Per
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Nilsson, K. Peter R.
    Linköping University, Department of Physics, Chemistry and Biology, Chemistry. Linköping University, Faculty of Science & Engineering.
    Antoni, Gunnar
    Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
    11C and 18FRadiolabeling of Tetra- and Pentathiophenes as PET-ligands for Amyloid Protein Aggregates2016In: ACS Medicinal Chemistry Letters, ISSN 1948-5875, E-ISSN 1948-5875, Vol. 7, no 4, 368-373 p.Article in journal (Refereed)
    Abstract [en]

    Three oligothiophenes were evaluated as PET tracers for the study of local and systemic amyloidosis ex vivo using tissue from patients with amyloid deposits and in vivo using healthy animals and PET-CT. The ex vivo binding studies revealed that all three labeled compounds bound specifically to human amyloid deposits. Specific binding was found in the heart, kidney, liver and spleen. To verify the specificity of the oligothiophenes towards amyloid deposits, tissue sections with amyloid pathology were stained using the fluorescence exhibited by the compounds and evaluated with multiphoton microscopy. Furthermore, in vivo rat and monkey PET-CT studies showed very low uptake in the brain, pancreas and heart of the healthy animals indicating low non-specific binding to healthy tissue. The biological evaluations indicated that this is a promising group of compounds for the visualization of systemic and localized amyloidosis.

  • 14. Khan, Tanweera
    et al.
    Sundin, Anders
    Juhlin, Claes
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Surgery. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Långström, Bengt
    Bergström, Mats
    Eriksson, Barbro
    11C-metomidate PET imaging of adrenocortical cancer2003In: European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, Vol. 30, 403-410 p.Article in journal (Refereed)
  • 15.
    Johansson, Ted
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    11th Swedish System-on-Chip Conference Sponsored by SSCS-Sweden in May2011Other (Other (popular science, discussion, etc.))
  • 16.
    Larsson, Staffan
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Studies in Adult, Popular and Higher Education.
    124 teachers´views of the essence of teaching adults.1993In: ISATT conference: Teacher Thinking and Actions in varied contexts, August 10 - 15, 1993,1993, 1993Conference paper (Refereed)
    Abstract [en]

    Tolkning av lärares uppfattningar av vad som är särskilt med att undervisa vuxna, tolkat med underlag av relativt öppna intervjuer med 124 lärare i komvux.

  • 17.
    Ahmed Aamir, Syed
    et al.
    University of Bielefeld, Germany .
    Angelov, Pavel
    AnaCatum Design AB, Linkoping, Sweden .
    Wikner, Jacob
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    1.2-V Analog Interface for a 300-MSps HD Video Digitizer in Core 65-nm CMOS2014In: IEEE Transactions on Very Large Scale Integration (vlsi) Systems, ISSN 1063-8210, Vol. 22, no 4, 888-898 p.Article in journal (Refereed)
    Abstract [en]

    This paper describes the front-end of a fully integrated analog interface for 300 MSps, high-definition video digitizers in a system on-chip environment. The analog interface is implemented in a 1.2 V, 65-nm digital CMOS process and the design minimizes the number of power domains using core transistors only. Each analog video receiver channel contains an integrated multiplexer with a current-mode dc-clamp, a programmable gain amplifier (PGA) and a pseudo second-order RC low-pass filter. The digital charge-pump clamp is integrated with low-voltage bootstrapped tee-switches inside the multiplexer, while restoring the dc component of ac-coupled inputs. The PGA contains a four-stage fully symmetric pseudo-differential amplifier with common-mode feedforward and inherent common-mode feedback, utilized in a closed loop capacitive feedback configuration. The amplifier features offset cancellation during the horizontal blanking. The video interface is evaluated using a unique test signal over a range of video formats for INL+/DNL+, INL-/DNL-. The 0.07-0.39 mV INL, 2-70 mu V DNL, and 66-74 dB of SFDR, enable us to target various formats for 9-12 bit Low-voltage digitizers.

  • 18.
    Lundberg, Peter
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Radio Physics. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics.
    Ekblad, Alf
    Nilsson, Mats
    13C NMR spectroscopy studies of forest soil microbial activity: Glucose uptake and fatty acid biosynthesis2001In: Soil Biology and Biochemistry, ISSN 0038-0717, Vol. 33, no 4-5, 621-632 p.Article in journal (Refereed)
    Abstract [en]

    The intimate association of soil microorganisms with the soil matrix complicates analysis of their metabolism, since thorough separation of intact cells from the matrix is very difficult using standard protocols. Thus, in the study reported here, in situ glucose decomposition and metabolism in humus from a coniferous forest soil was monitored and evaluated using 'solution state' 13C NMR, which can be used in a non-invasive manner. [U-13C] glucose was added at a concentration of 1.73 mmol C g-1 dry organic matter, which is known to allow maximal substrate induced respiration (SIR), and the microbial metabolism of the added C was followed over a period of 28 days. The data showed that ~50% of the added glucose was consumed within three days, coinciding with the appearance of label in CH3, -CH2- and -CH = CH-groups, and in glycerol-carbons, suggesting that olefinic triacylglycerols were being formed, probably located in oil droplets. During days two to three, around 40% of the consumed glucose C was allocated into solid state components, about 40% was respired and about 20% was found as triglycerols. The triacylglycerol signal reached a maximum after 13 days, but subsequently declined by 60%, as the triacylglycerols were apparently consumed, by day 28 of the incubation. Our results indicate there was an initial formation of structural microbial C (solid state carbon) followed by formation of storage lipid C, which subsequently decreased, probably because it was used to provide the organisms with energy when the external energy source (i.e. the glucose) was depleted. The formation of unsaturated triacylglycerols, typical storage metabolites of eucaryotes, suggests that fungi were the most active organisms in the glucose degradation. ⌐ 2001 Elsevier Science Ltd.

  • 19.
    Rastgoo Lahrood, Atena
    et al.
    Technical University of Munich, Germany; Nanosyst Initiat Munich, Germany; Centre NanoScience, Germany.
    Björk, Jonas
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Chemistry. Linköping University, Faculty of Science & Engineering.
    Heckl, Wolfgang M.
    Technical University of Munich, Germany; Nanosyst Initiat Munich, Germany; Centre NanoScience, Germany; Deutsch Museum, Germany.
    Lackinger, Markus
    Technical University of Munich, Germany; Nanosyst Initiat Munich, Germany; Centre NanoScience, Germany; Deutsch Museum, Germany.
    1,3-Diiodobenzene on Cu(111) - an exceptional case of on-surface Ullmann coupling2015In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 51, no 68, 13301-13304 p.Article in journal (Refereed)
    Abstract [en]

    Ullmann coupling of 1,3-diiodobenzene is studied on Cu(111) surfaces in ultra-high vacuum (UHV). In situ Scanning Tunneling Microscopy (STM) at room temperature revealed an unexpected ordered arrangement of highly uniform reaction products adsorbed atop a closed iodine monolayer.

  • 20.
    Krus, Petter
    et al.
    Linköping University, Department of Management and Engineering, Fluid and Mechatronic Systems. Linköping University, The Institute of Technology.
    Sethson, MagnusLinköping University, Department of Management and Engineering, Fluid and Mechatronic Systems. Linköping University, The Institute of Technology.Ericson, LiselottLinköping University, Department of Management and Engineering, Fluid and Mechatronic Systems. Linköping University, The Institute of Technology.
    13th Scandinavian International Conference on Fluid Power, June 3-5, 2013, Linköping, Sweden2013Conference proceedings (editor) (Refereed)
  • 21.
    Lärkner, Bengt
    Linköping University, The Tema Institute, Department of Communications Studies, Art and Visual Communication . Linköping University, Faculty of Arts and Sciences.
    14 bilder / analyserade av Bengt Lärkner1978Book (Other (popular science, discussion, etc.))
  • 22.
    Eriksson, Fredrik
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics.
    Johansson, GA
    Hertz, HM
    Gullikson, EM
    Kreissig, U
    Birch, Jens
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Thin Film Physics.
    14.5% near-normal incidence reflectance of Cr/Sc x-ray multilayer mirrors for the water window2003In: Optics Letters, ISSN 0146-9592, Vol. 28, no 24, 2494-2496 p.Article in journal (Refereed)
    Abstract [en]

    Cr/Sc multilayer mirrors, synthesized by ion-assisted magnetron sputter deposition, are proved to have a high near-normal reflectivity of R = 14.5% at a grazing angle of 87.5degrees measured at the wavelength A = 3.11 nm, which is an improvement of more than 31% compared with previously published results. Elastic recoil detection analyses show that the mirrors contained as much as 15 at. % of N and traces of C and O. Soft x-ray reflectivity simulations reveal interface widths of sigma = 0.34 nm and an exceptionally small layer thickness drift of similar to1.6 X 10(-5) nm/multilayer period throughout the stack. Simulations show that a reflectivity of R = 25.6% is attainable if impurities and layer thickness drift can be eliminated. The abrupt interfaces are achieved with ion assistance with a low ion energy of 24 eV and high ion-to-metal flux ratios of 7.1 and 23.1 during Cr and Se sputter deposition, respectively. In addition, a near-normal incidence reflectivity of 5.5% for the C VI emission line (lambda = 3.374 nm) from a laser plasma source was verified. (C) 2003 Optical Society of America.

  • 23.
    Holmbom, Martin
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
    Giske, Christian G.
    Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.; Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden..
    Fredrikson, Mats
    Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences.
    Östholm Balkhed, Åse
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases.
    Claesson, Carina
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Nilsson, Lennart E
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences.
    Hoffmann, Mikael
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Hanberger, Håkan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Infectious Diseases.
    14-Year Survey in a Swedish County Reveals a Pronounced Increase in Bloodstream Infections (BSI). Comorbidity: An Independent Risk Factor for Both BSI and Mortality2016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 11Article in journal (Refereed)
    Abstract [en]

    Objectives: we assessed the incidence, risk factors and outcome of BSI over a 14-year period (2000-2013) in a Swedish county.

    Methods: retrospective cohort study on culture confirmed BSI among patients in the county of Östergötland, Sweden, with approximately 440,000 inhabitants. A BSI was defined as either community-onset BSI (CO-BSI) or hospital-acquired BSI (HA-BSI).

    Results: of a total of 11,480 BSIs, 67% were CO-BSI and 33% HA-BSI. The incidence of BSI increased by 64% from 945 to 1,546 per 100,000 hospital admissions per year during the study period. The most prominent increase, 83% was observed within the CO-BSI cohort whilst HA-BSI increased by 32%. Prescriptions of antibiotics in outpatient care decreased with 24% from 422 to 322 prescriptions dispensed/1,000 inhabitants/year, whereas antibiotics prescribed in hospital increased by 67% (from 424 to 709 DDD per 1,000 days of care). The overall 30-day mortality for HA-BSIs was 17.2%, compared to 10.6% for CO-BSIs, with an average yearly increase per 100,000 hospital admissions of 2 and 5% respectively. The proportion of patients with one or more comorbidities, increased from 20.8 to 55.3%. In multivariate analyses, risk factors for mortality within 30 days were: HA-BSI (2.22); two or more comorbidities (1.89); single comorbidity (1.56); CO-BSI (1.21); male (1.05); and high age (1.04).

    Conclusion: this survey revealed an alarming increase in the incidence of BSI over the 14-year study period. Interventions to decrease BSI in general should be considered together with robust antibiotic stewardship programmes to avoid both over- and underuse of antibiotics.

  • 24.
    Ni, Wei-Xin
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Surface and Semiconductor Physics .
    Du, Chun-Xia
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    Duteil, F.
    Elfving, Anders
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Surface and Semiconductor Physics .
    Hansson, Göran
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Surface and Semiconductor Physics .
    1.54 µm light emitting devices based on Er/O-doped Si layered structures grown by molecular beam epitaxy2001In: Optical materials (Amsterdam), ISSN 0925-3467, Vol. 17, no 1-2, 65-69 p.Conference paper (Other academic)
    Abstract [en]

    Two types of Si:Er light emitting devices have been processed and characterized with an aim to efficiently use hot electrons for impact excitation. One is a p+-SiGe/i-Si/n-Si:Er:O/n+-Si tunneling diode with a design favoring electron tunneling from the SiGe valence band to the Si conduction band and subsequent acceleration. Another type of Si:Er light emitters is based on a heterojunction bipolar transistor (HBT) structure containing an Er-doped active layer in the collector. In these devices, one can introduce hot electrons from the HBT emitter in a controlled way with a collector bias voltage prior to the avalanche breakdown to improve the impact excitation efficiency. Intense electroluminescence was observed at 300 K at low current (0.1 A cm-2) and low bias (3 V). An impact cross-section value of 1 × 10-14 cm2 has been estimated, which is a 100-fold increase compared with the values reported from any other type of Er-doped LEDs. © 2001 Elsevier Science B.V.

  • 25.
    Halling, Jon
    Linköping University, Department of Electrical Engineering.
    1553-Simulator. In-/uppspelning av databusstrafik med hjälp av FPGA2002Independent thesis Basic level (professional degree)Student thesis
    Abstract [en]

    At Saab Aerospace in Linköping, components for measurement systems to the fighter aircraft JAS 39 Gripen are developed. In this activity you sometimes want to record the traffic transmitted on the data busses that connects different sys-tems. This traffic on the data busses is using the military standard MIL-STD-1553.

    This project has aimed to create a system for recording and sending 1553-data. The system is used on an ordinary personal computer, equipped with a recon- figurable I/O card that among others has a programmable logic circuit (FPGA). The recorded data are stored on a hard drive. The system has a graphical user interface, where the user can configure different methods of filtering the data, and other preferences.

    The completed system has currently the capacity to record one channel. This works excellent and the system basically meets all the requirements stated at the start of the project. By using this system instead of the commercial available systems on the market one will get a competitive alternative. If the system where to be developed further, with more channels, it would get even more price worth. Both in case of price per channel, but also in functionality. This is because it is possible to design exactly the functions the user demands. But the current version is already fully functional and competitive compared to commercial systems.

  • 26.
    Hansson, Martin
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Mesgarzadeh, Behzad
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    1.56 HGz On-chip Resonant Clocking in 130nm CMOS.2006In: IEEE Custom Integrated Circuits Conference CICC,2006, Piscataway: IEEE , 2006, 241- p.Conference paper (Refereed)
  • 27.
    Hansson, Martin
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Mesgarzadeh, Behzad
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    1.56-GHz On-Chip Resonant Clocking with 2.3X Clock Power-Saving in 130-nm CMOS2006In: Proceedings of the European Solid-State Circuit Conference (ESSCIRC), 2006, 464-467 p.Conference paper (Refereed)
    Abstract [en]

    This paper presents a detailed clock jitter characteristic analysis of a fully integrated 1.5-GHz resonant clocking fabricated in 130-nm CMOS, with 57% total clock power saving, compared to the conventional clocking implemented in the same test-chip. The jitter measurement result is in good agreement with the jitter analysis. Furthermore, a jitter-suppression technique based on injection locking phenomenon has been utilized to reduce the clock jitter and to solve the jitter peaking problem. Measurements show about 50% peak-to-peak clock jitter reduction from 28.4 ps to 14.5 ps after the activation of the injection locking.

  • 28.
    Nilsson, Line
    et al.
    Aarhus University, Denmark.
    Palm, Fredrik
    Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Uppsala University, Sweden.
    Norregaard, Rikke
    Aarhus University, Denmark.
    15-Deoxy-Delta(12,14)-prostaglandin J(2) Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction2017In: Mediators of Inflammation, ISSN 0962-9351, E-ISSN 1466-1861, 3924912Article in journal (Refereed)
    Abstract [en]

    Urinary obstruction is associated with inflammation and oxidative stress, leading to renal dysfunction. Previous studies have shown that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) has both antioxidant and anti-inflammatory effects. Using a unilateral ureteral obstruction (UUO) mouse model, we examined the effects of 15d-PGJ(2) on oxidative stress and inflammation in the kidney. Mice were subjected to UUO for 3 days and treated with 15d-PGJ(2). Protein and RNA expression were examined using immunoblotting and qPCR. 15d-PGJ(2) increased NF-E2-related nuclear factor erythroid-2 (Nrf2) protein expression in response to UUO, and heme oxygenase 1 (HO-1), a downstream target of Nrf2, was induced by 15d-PGJ(2). Additionally, 15d-PGJ(2) prevented protein carbonylation, a UUO-induced oxidative stress marker. Inflammation, measured by nuclear NF-kappa B, F4/80, and MCP-1, was increased in response to UUO and further increased by 15d-PGJ(2). Renal injury was aggravated by 15d-PGJ(2) treatment as measured by kidney injury molecule-1 (KIM-1) and cortical caspase 3 content. No effect of 15d-PGJ(2) was observed on renal function in mice subjected to UUO. This study illustrates differentiated functioning of 15d-PGJ(2) on inflammation and oxidative stress in response to obstructive nephropathy. High concentrations of 15d-PGJ(2) protects against oxidative stress during 3-day UUO in mice; however, it aggravates the associated inflammation.

  • 29.
    Browaldh, Nanna
    et al.
    Karolinska University Hospital.
    Friberg, Danielle
    Karolinska University Hospital.
    Svanborg, Eva
    Linköping University, Department of Clinical and Experimental Medicine, Clinical Neurophysiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Neurophysiology UHL.
    Nerfeldt, Pia
    Karolinska University Hospital.
    15-year efficacy of uvulopalatopharyngoplasty based on objective and subjective data2011In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 131, no 12, 1303-1310 p.Article in journal (Refereed)
    Abstract [en]

    Conclusions: This follow-up showed a stable and significant decrease in median oxygen desaturation index 4% (ODI(4)) values over the years. Approximately two-thirds of the patients fulfilled the success criteria (ODI4 reduction of 50% and andlt;20) after 15 years. A majority had improved/cured excessive daytime sleepiness (EDS) and were satisfied. No increased mortality rate was seen. Objectives: To evaluate sleep apnoea recordings and symptoms in patients with obstructive sleep apnoea syndrome 15 years after uvulopalatopharyngoplasty (UPPP) compared to baseline and previous follow-ups. Methods: This was a non-randomized, prospective intervention study on 50 patients who underwent UPPP during 1985-88. Their initial median age was 49 years (range 38-71) and ODI4 was 26.5 (4-82). Results: In all, 13 patients had died; 26 patients underwent sleep apnoea recordings. Median ODI4 had decreased from 26.5 (range 4-82) to 8.5 (0-60), p andlt; 0.01, a mean reduction of 52%; 65% of patients achieved the success criteria. One-third was objectively categorized as non-snorers. Median body mass index was unchanged. The questionnaires were answered by 32 of 37 patients; 88% reported improved or cured EDS and 78% were satisfied. Pharyngeal disturbances ratings were low. The standardized mortality rate did not differ from the general Swedish population.

  • 30.
    Ågren, Henrik
    Högskolan i Gävle.
    1600-talets postväsende som företagsekonomisk utmaning [recension av]: Magnus Linnarsson, Postgång på växlande villkor: det svenska postväsendets organisation under stormaktstiden, Södertörn doctoral dissertations 49, (Lund: Nordic Academic Press 2010). 281 s. (Summary in English: Postal service on shifting conditions: the organization of the Swedish postal service, c. 1600–1720).2011In: Historisk Tidskrift (S), ISSN 0345-469X, Vol. 131, no 2, 340-347 p.Article, book review (Refereed)
  • 31.
    Kallstrom, Ann-Christine
    et al.
    Helsingborg Hospital.
    Salme, Rebecka
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Ryden, Lisa
    Lund University.
    Nordenskjöld, Bo
    Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    Jonsson, Per-Ebbe
    Helsingborg Hospital.
    Stål, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    17 beta-Hydroxysteroid dehydrogenase type 1 as predictor of tamoxifen response in premenopausal breast cancer2010In: EUROPEAN JOURNAL OF CANCER, ISSN 0959-8049, Vol. 46, no 5, 892-900 p.Article in journal (Refereed)
    Abstract [en]

    17 beta-Hydroxysteroid dehydrogenases (17HSDs) are involved in the local regulation of sex steroids. 17HSD1 converts oestrone (El) to the more potent oestradiol (E2) and 17HSD2 catalyses the reverse reaction. The aim of this study was to investigate the expression of these enzymes in premenopausal breast cancers and to analyse if they have any prognostic or tamoxifen predictive value. Premenopausal patients with invasive breast cancer, stage II (UICC), were randomised to either 2 years of adjuvant tamoxifen (n = 276) or no tamoxifen (n = 288). The median follow-up was 13.9 years (range 10.5-17.5). The expression of 17HSD1 and 17HSD2 was analysed with immunohistochemistry using tissue microarrays. The enzyme expression level (-/+/++/+++) was successfully determined in 396 and 373 tumours, respectively. Women with hormone-receptor positive tumours, with low levels (-/+/++) of 17HSD1, had a 43% reduced risk of recurrence, when treated with tamoxifen (Hazard Ratio (HR) = 0.57; 95% confidence interval (CI), 0.37-0.86; p = 0.0086). On the other hand high expression (+++) of 17HSD1 was associated with no significant difference between the two treatment arms (HR = 0.91; 95% CI, 0.43-1.95; p = 0.82). The interaction between 17HSD1 and tamoxifen was significant during the first 5 years of follow-up (p = 0.023). In the cohort of systemically untreated patients no prognostic importance was observed for 17HSD1. We found no predictive or prognostic value for 17HSD2. This is the first report of 17HSD1 in a cohort of premenopausal women with breast cancer randomised to tamoxifen. Our data suggest that 17HSD1 might be a predictive factor in this group of patients.

  • 32.
    Jansson , Agneta
    Linköping University, Department of Clinical and Experimental Medicine, Oncology . Linköping University, Faculty of Health Sciences.
    17Beta-hydroxysteroid dehydrogenase enzymes and breast cancer2009In: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ISSN 0960-0760 , Vol. 114, no 1-2, 64-67 p.Article in journal (Refereed)
    Abstract [en]

    Sex steroids play an important role in the development and differentiation in several tissues. Biologically active hormones that are locally converted in endocrine organs in the tissue where they exert their effects without release into extracellular space is a field of endocrinology that has been called intracrinology. In pre-menopausal women the ovary is the main source of estrogens, but in post-menopausal women the estrogen production as main site of synthesis moves to peripheral tissues and almost all of the sex steroids are synthesised from precursors of adrenal origin. In breast cancer 60-80% of the tumors express high levels of oestrogen receptor (ER) alpha which gives estrogen a proliferative effect. Breast tumors tend to have a higher intratumoral estrogen concentration than normal breast tissue and plasma, and in situ synthesis and the metabolism of estrogens is believed to be of great importance for the development and progression of the disease. The activity of estrogen metabolizing enzymes in breast are mainly aromatase, estrone sulfatases and 17HSD enzymes. 17HSD1 and 17HSD2 are the family members known to be of main importance in breast cancer. High expression of 17HSD1 has been associated to poor prognosis in breast cancer and late relapse among patients with ER-positive tumors. One of the mechanisms behind high 17HSD1 expression is gene amplification. Low or absent expression of 17HSD2 is associated to decreased survival in ER-positive breast cancer. 17HSD14 is one of the latest discovered 17HSD enzymes, transfection of 17HSD14 in human breast cancer cells significantly decreased the levels of estradiol in the culture medium. Low expression of 17HSD14 mRNA expression in breast cancer was correlated to decreased survival.

    The understanding of intratumoral synthesis of sex steroids in breast cancer is crucial to understand the disease both in pre- and post-menopausal women. Further studies are desirable to state the direct role of these enzymes in breast cancer and which patients that may benefit from new therapeutic strategies targeting 17HSD enzymes. The new inhibitors targeting 17HSD1 have shown promising results in preclinical studies to have clinical potential in the future.

  • 33.
    Jansson, Agneta
    et al.
    Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
    Gunnarsson, Cecilia
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Cohen, Maja
    Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
    Sivik, Tove
    Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
    Stål, Olle
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Oncology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
    17β-hydroxysteroid dehydrogenase 14 affects estradiol levels in breast cancer cells and is a prognostic marker in estrogen receptor-positive breast cancer2006In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 66, no 23, 11471-11477 p.Article in journal (Refereed)
    Abstract [en]

    Estrogens have an important role in the progression of breast cancer. The 17β-hydroxysteroid dehydrogenase (17HSD) family has been identified to be of significance in hormone-dependent tissues. 17HSD1 and 17HSD2 are the main 17HSD enzymes involved in breast cancer investigated this far, but it is possible that other hormone-regulating enzymes have a similar role. 17HSD5 and 17HSD12 are associated with sex steroid metabolism, and 17HSD14 is a newly discovered enzyme that may be involved in the estrogen balance. The mRNA expression of 17HSD5, 17HSD12, and 17HSD14 were analyzed in 131 breast cancer specimens by semiquantitative real-time PCR. The results were compared with recurrence-free survival and breast cancer-specific survival of the patients. The breast cancer cell lines MCF7, SKBR3, and ZR75-1 were transiently transfected with 17HSD14 to investigate any possible effect on estradiol levels. We found that high 17HSD5 was related to significantly higher risk of late relapse in estrogen receptor (ER)-positive patients remaining recurrence-free later than 5 years after diagnosis (P = 0.02). No relation to 17HSD12 expression was found, indicating that 17HSD12 is of minor importance in breast cancer. Patients with ER-positive tumors with high expression levels of 17HSD14 showed a significantly better prognosis about recurrence-free survival (P = 0.008) as well as breast cancer-specific survival (P = 0.01), confirmed by multivariate analysis (P = 0.04). Transfection of 17HSD14 in the human breast cancer cells MCF7 and SKBR3 significantly decreased the levels of estradiol, presenting an effect of high expression levels of the enzyme. ©2006 American Association for Cancer Research.

  • 34.
    Sivik, Tove
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
    Gunnarsson, Cecilia
    Linköping University, Department of Clinical and Experimental Medicine, Medical Genetics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
    Fornander, Tommy
    Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
    Nordenskjöld, Bo
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Skoog, Lambert
    Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
    Stål, Olle
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Oncology.
    Jansson, Agneta
    Linköping University, Department of Clinical and Experimental Medicine, Oncology. Linköping University, Faculty of Health Sciences.
    17β-hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer2012In: PLoS ONE, ISSN 1932-6203, Vol. 7, no 7, e40568- p.Article in journal (Refereed)
    Abstract [en]

    Introduction: 17β-hydroxysteroid dehydrogenases (17βHSDs) are important enzymes regulating the pool of bioactive steroids in the breast. The current study was undertaken in order to evaluate implications of 17βHSD14 in breast cancer, measuring 17βHSD14 protein expression in breast tumours.

    Methods: An antibody targeting the 17βHSD14 antigen was generated and validated using HSD17B14-transfected cells and a peptide-neutralising assay. Tissue microarrays with tumours from 912 post-menopausal women diagnosed with lymph node-negative breast cancer, and randomised to adjuvant tamoxifen or no endocrine treatment, were analysed for 17βHSD14 protein expression with immunohistochemistry.

    Results: Results were obtained from 847 tumours. Patients with oestrogen positive tumours with high 17βHSD14 expression had fewer local recurrences when treated with tamoxifen (HR 0.38; 95% C.I. 0.19–0.77, p = 0.007) compared to patients with lower tumoural 17βHSD14 expression, for whom tamoxifen did not reduce the number of local recurrences (HR 1.19; 95% C.I. 0.54–2.59; p = 0.66). No prognostic importance of 17βHSD14 was seen for systemically untreated patients.

    Conclusions: Using a highly specific validated antibody for immunohistochemical analysis of a large number of breast tumours, we have shown that tumoural expression levels of 17βHSD14 can predict the outcome of adjuvant tamoxifen treatment in terms of local recurrence-free survival in patients with lymph node-negative ER+ breast cancer. The results need be verified to confirm any clinical relevance.

  • 35.
    Gunnarsson, Cecilia
    et al.
    Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
    Hellqvist, Eva
    Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
    Stål, Olle
    Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
    17β-hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer2005In: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 92, no 3, 547-552 p.Article in journal (Refereed)
    Abstract [en]

    The 17β-hydroxysteroid dehydrogenase (17HSD) enzymes are involved in the local regulation of sex steroids. The 17HSD type 1 enzyme catalyses the interconversion of the weak oestrone (E1) to the more potent oestradiol (E2), whereas 17HSD type 2 catalyses the oxidation of E2 to E1. The aim of this study was to correlate the expression of these enzymes in the tumour with the recurrence-free survival of tamoxifen-treated breast cancer patients. We used real-time reverse transcriptase PCR to investigate the mRNA expression of 17HSD types 1 and 2 in tumour samples from 230 postmenopausal patients. For the patients with oestrogen receptor (ER)-positive breast cancer, we found a statistically significant positive correlation between recurrence-free survival and expression of 17HSD type 2 (P = 0.026). We examined the ratio of 17HSD types 2 and 1, and ER-positive patients with low ratios showed a significantly higher rate of recurrence than those with higher ratios (P = 0.0047), ER positive patients with high expression levels of 17HSD type 1 had a significantly higher risk for late relapse (P = 0.0051). The expression of 17HSD types 1 and 2 in breast cancer differs from the expression of these enzymes in normal mammary gland, and this study indicates that the expression has prognostic significance in breast cancer.

  • 36.
    Ludvigsson, David
    Historiska institutionen, Uppsala universitet, Uppsala.
    1800-talets skolväsende2008In: Signums svenska kulturhistoria: Karl Johantiden / [ed] Jakob Christensson, Stockholm: Bokförlaget Signum, 2008Chapter in book (Other academic)
    Abstract [sv]

    Om boken:

    Karl Johantiden är ett brytningsskede. Efter freden i Kiel och erövringen av Norge infaller en lång fredsperiod. Befolkningen växer rekordartat, till stor del en följd av skiftena och ett alltmer rationellt jordbruk. I religiöst avseende utmanas statskyrkan av olika väckelserörelser. Nationstanken gror och de svenska högskolorna fyller numera de bildade klassernas studiebehov. Samtidigt vinner folkbildningssträvandena terräng och skolväsendet stöps om genom 1842 års folkskolestadga. I politiskt avseende behåller kungamakten mycket av makten men liberala strömningar gör sig alltmer gällande i den framväxande pressen.Karl Johantiden är den sjätte delen av Signums svenska kulturhistoria. Tretton författare behandlar bland annat politik, statistik och samhällsplanering, press, kyrka och tro, skolvärld, jakt, ordspråk, illustrerade barnböcker och minnesalbum.

  • 37.
    Carlsson Tedgren, Åsa
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Radiation Physics . Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics.
    Grindborg, J-E
    Stockholm.
    192-Ir source strength dosimetry audit in Sweden2007In: 9th Biennial ESTRO meeting on physics and radiation technology for clinical radiotherapy,2007, 2007, S143-S143 p.Conference paper (Other academic)
    Abstract [en]

    Posters Brachytherapy, publicerad i Radiotherapy and Oncology.

  • 38.
    Zhang, Xuanjun
    et al.
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Xie, Yi
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Zhao, Qingrui
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Tian, Yupeng
    Department of Chemistry, Anhui University, China.
    1-D coordination polymer template approach to CdS and HgS aligned-nanowire bundles2003In: New Journal of Chemistry, ISSN 1144-0546, E-ISSN 1369-9261, Vol. 27, no 5, 827-830 p.Article in journal (Refereed)
    Abstract [en]

    A 1D inorganic coordination polymer template route was firstly developed to synthesize metal sulfide aligned-nanowire bundles. Based on this strategy, CdS and HgS aligned-nanowire bundles with high yields were successfully prepared in a water system at room temperature using KCd(NCS)3 as a soft template. The results revealed that the morphologies of the MS (M=Cd, Hg) aligned-nanowire bundles were uniform with lengths of several microns and the diameters of each single wire were ca. 10–30 nm and 60–80 nm for CdS and HgS, respectively.

  • 39. Atlasov, K.A.
    et al.
    Karlsson, Fredrik
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology, Materials Science .
    Rudra, A.
    Kapon, E.
    1D Exciton-Photon Confinements in V-groove Quantum Wires Embedded into Photonic-Crystal Membrane Microcavities2007In: Second International Conference on One-dimensional Nanomaterials ICON 2007,2007, 2007Conference paper (Other academic)
  • 40.
    A Atlasov, Kirill
    et al.
    Ecole Polytech Fed Lausanne, Lab Phys Nanostruct, CH-1015 Lausanne, Switzerland .
    Felici, Marco
    Ecole Polytech Fed Lausanne, Lab Phys Nanostruct, CH-1015 Lausanne, Switzerland .
    Karlsson, Fredrik
    Linköping University, Department of Physics, Chemistry and Biology, Semiconductor Materials. Linköping University, The Institute of Technology.
    Gallo, Pascal
    Ecole Polytech Fed Lausanne, Lab Phys Nanostruct, CH-1015 Lausanne, Switzerland .
    Rudra, Alok
    Ecole Polytech Fed Lausanne, Lab Phys Nanostruct, CH-1015 Lausanne, Switzerland .
    Dwir, Benjamin
    Ecole Polytech Fed Lausanne, Lab Phys Nanostruct, CH-1015 Lausanne, Switzerland .
    Kapon, Eli
    Ecole Polytech Fed Lausanne, Lab Phys Nanostruct, CH-1015 Lausanne, Switzerland .
    1D photonic band formation and photon localization in finite-size photonic-crystal waveguides2010In: OPTICS EXPRESS, ISSN 1094-4087, Vol. 18, no 1, 117-122 p.Article in journal (Refereed)
    Abstract [en]

    A transition from discrete optical modes to 1D photonic bands is experimentally observed and numerically studied in planar photonic-crystal (PhC) L-N microcavities of length N. For increasing N the confined modes progressively acquire a well-defined momentum, eventually reconstructing the band dispersion of the corresponding waveguide. Furthermore, photon localization due to disorder is observed experimentally in the membrane PhCs using spatially resolved photoluminescence spectroscopy. Implications on single-photon sources and transfer lines based on quasi-1D PhC structures are discussed.

  • 41.
    Lundberg, Peter
    et al.
    Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Department of Biochemistry, University of Sydney, Australia.
    Dudman, Nicholas P.
    Department of Cardiovascular Medicine, Prince Henry Hospital, University of New South Wales, Australia.
    Kuchel, Philip W.
    Department of Biochemistry, University of Sydney, Australia.
    Wilcken, David E. L.
    Present address: Department of Physical Chemistry, University of Umeå, Umeå, Sweden.
    1H NMR determination of urinary betaine in patients with premature vascular disease and mild homocysteinemia1995In: Clinical Chemistry, ISSN 0009-9147, E-ISSN 1530-8561, Vol. 41, no 2, 275-283 p.Article in journal (Refereed)
    Abstract [en]

    Urinary N,N,N-trimethylglycine (betaine) and N,N-dimethylglycine (DMG) have been identified and quantified for clinical purposes by proton nuclear magnetic resonance (1H NMR) measurement in previous studies. We have assessed these procedures by using both one-dimensional (1-D) and 2-D NMR spectroscopy, together with pH titration of urinary extracts to help assign 1H NMR spectral peaks. The betaine calibration curve linearity was excellent (r = 0.997, P = 0.0001) over the concentration range 0.2-1.2 mmol/L, and CVs for replicate betaine analyses ranged from 7% (n = 10) at the lowest concentration to 1% (n = 9) at the highest. The detection limit for betaine was < 15 mumol/L. Urinary DMG concentrations were substantially lower than those of betaine. Urinary betaine and DMG concentrations measured by 1H NMR spectroscopy from 13 patients with premature vascular disease and 17 normal controls provided clinically pertinent data. We conclude that 1H NMR provides unique advantages as a research tool for determination of urinary betaine and DMG concentrations.

  • 42.
    Bengtsson, Håkan
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Svensson, Christer
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    2 Gb/s decision feedback equalizer in 3.3 V 0.35 µm CMOS2004In: Circuits, Signals, and Systems (CSS 2004) / [ed] M.H. Rashid, 2004Conference paper (Refereed)
    Abstract [en]

    A 2 Gb/s decision feedback equalizer is implemented in a 0.35 m CMOS process and experimentally demonstrated. Speed is enhanced through optimization of the unavoidable loop in a decision feedback equalizer, parallelism, differential current mode frontend, fast sense amplifier style comparators and single-phase flip-flops.

  • 43.
    Lykke, Nina
    Linköping University, The Tema Institute, The Department of Gender Studies. Linköping University, Faculty of Arts and Sciences.
    20 spørgsmål til kønsforskeren Nina Lykke2014In: Frit flet: fællesbogen / [ed] Naja Marie Aidt, Line Knutzon, Mette Moestrup, Copenhagen: Gyldendal Litteratur, 2014, 1, 194-205 p.Chapter in book (Other (popular science, discussion, etc.))
    Abstract [en]

    Prompted via 20 written questions from the literary authors of the mixed genre text collection, poet, short story writer,  and novelist, Naja Marie Aidt, dramatist Line Knutzon, and poet Mette Moestrup,  Nina Lykke gives a broad account of key ideas and concepts in contemporary feminist thought as a background for the poetic articulation of feminist and anti-racist approaches of the collection.

  • 44.
    Jaarsma, Tiny
    et al.
    Linköping University, Department of Social and Welfare Studies, Division of Health, Activity and Care. Linköping University, Faculty of Arts and Sciences.
    Strömberg, Anna
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Cardiology in Linköping.
    20 Things You Didn't Know About European Cardiac Nurses2014In: Journal of Cardiovascular Nursing, ISSN 0889-4655, E-ISSN 1550-5049, Vol. 29, no 4, 291-292 p.Article in journal (Other academic)
  • 45.
    Jaarsma, Tiny
    et al.
    Linköping University, Department of Social and Welfare Studies, Division of Health, Activity and Care. Linköping University, Faculty of Arts and Sciences.
    Steinke, Elaine
    Wichita State University, KS, USA .
    20 Things You Didnt Know About Sex and Heart Disease2014In: Journal of Cardiovascular Nursing, ISSN 0889-4655, E-ISSN 1550-5049, Vol. 29, no 3, 207-208 p.Article in journal (Other academic)
  • 46.
    Berggren, Karl-Fredrik
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Theoretical Physics . Linköping University, The Institute of Technology.
    Persson, Bengt
    Linköping University, Department of Physics, Chemistry and Biology, Bioinformatics . Linköping University, The Institute of Technology.
    20 years in HPC 1989-20092009Other (Other (popular science, discussion, etc.))
  • 47.
    Jantunen, Liisa
    et al.
    Environment Canada, Canada.
    Wong, Fiona
    Stockholm University.
    Gawor, Anya
    Environment Canada.
    Kylin, Henrik
    Linköping University, The Tema Institute, Tema Environmental Change. Linköping University, Faculty of Arts and Sciences.
    Helm, Paul
    Ontario Ministry of the Environment, Canada.
    Stern, Gary
    University of Manitoba, Canada.
    Strachan, William
    Environment Canada, Canada.
    Burniston, Deborah
    Environment Canada, Canada.
    Bidleman, Terry
    Umeå University.
    20 Years of Air-Water Gas Exchange Observations for Pesticides in the Western Arctic Ocean2015In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 49, no 23, 13844-13852 p.Article in journal (Refereed)
    Abstract [en]

    The Arctic has been contaminated by legacy organochlorine pesticides (OCPs) and currently used pesticides (CUPs) through atmospheric transport and oceanic currents. Here we report the time trends and air−water exchange of OCPs and CUPs from research expeditions conducted between 1993 and 2013. Compounds determined in both air and water were trans- and cis-chlordanes (TC, CC), trans- and cis-nonachlors (TN, CN), heptachlor exo-epoxide (HEPX), dieldrin (DIEL), chlorobornanes (ΣCHBs and toxaphene), dacthal (DAC), endosulfans and metabolite endosulfan sulfate (ENDO-I, ENDO-II, and ENDO SUL), chlorothalonil (CHT), chlorpyrifos (CPF), and trifluralin (TFN). Pentachloronitrobenzene (PCNB and quintozene) and its soil metabolite pentachlorothianisole (PCTA) were also found in air. Concentrations of most OCPs declined in surface water, whereas some CUPs increased (ENDO-I, CHT, and TFN) or showed no significant change (CPF and DAC), and most compounds declined in air. Chlordane compound fractions TC/(TC + CC) and TC/(TC + CC + TN) decreased in water and air, while CC/(TC + CC + TN) increased. TN/(TC + CC + TN) also increased in air and slightly, but not significantly, in water. These changes suggest selective removal of more labile TC and/or a shift in chlordane sources. Water−air fugacity ratios indicated net volatilization (FR > 1.0) or near equilibrium (FR not significantly different from 1.0) for most OCPs but net deposition (FR < 1.0) for ΣCHBs. Net deposition was shown for ENDO-I on all expeditions, while the net exchange direction of other CUPs varied. Understanding the processes and current state of air−surface exchange helps to interpret environmental exposure and evaluate the effectiveness of international protocols and provides insights for the environmental fate of new and emerging chemicals.

  • 48.
    Wojtowicz, Wit
    et al.
    Linköping University, Faculty of Educational Sciences. Linköping University, Department of Behavioural Sciences, Studies in Adult, Popular and Higher Education.
    Maliszewski, T
    Zerko, J
    20 years of Co-operation between the Universities in Linköping and Gdansk. Anthology of Social and Behavioural Sciences2005Book (Other academic)
  • 49.
    Pakiam Eliason, Barbro
    Linköping University, The Tema Institute, Department of Communications Studies, Art and Visual Communication . Linköping University, Faculty of Arts and Sciences.
    2000-talets änglasymbol: en djupanalys2002Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The contemporary angel-symbol is deeply rooted in our cultural history, with connotations and implications leading to that inner transitional space where all creative activity takes place. This essay investigates the history of the depiction of angels, visions of angels both ancient and modern, and includes psychological aspects of symbols as such. A closer look at surrounding symbols of angels will hopefully result in a greater understanding of the role of the angel-symbol within the context of visual culture, seen in the light of our own symbolic universe.

  • 50.
    Doherty, Patrick
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Computer and Information Science, KPLAB - Knowledge Processing Lab.
    al, et
    2003 AAAI Spring Symposium Series2003In: The AI Magazine, ISSN 0738-4602, Vol. 24, no 3, 131-140 p.Article in journal (Other academic)
    Abstract [en]

    The American Association for Artificial Intelligence, in cooperation with Stanford University’s Department of Computer Science, presented the 2003 Spring Symposium Series, Monday through Wednesday, 24–26 March 2003, at Stanford University.  The titles of the eight symposia were Agent-Mediated Knowledge Management, Computational Synthesis: From Basic Building Blocks to High- Level Functions, Foundations and Applications of Spatiotemporal Reasoning (FASTR), Human Interaction with Autonomous Systems in Complex Environments, Intelligent Multimedia Knowledge Management, Logical Formalization of Commonsense Reasoning, Natural Language Generation in Spoken and Written Dialogue, and New Directions in Question-Answering Motivation.

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