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  • 1.
    Hemdan, Tammer
    et al.
    University Hospital Uppsala, Sweden.
    Johansson, Robert
    Umeå University Hospital, Sweden.
    Jahnson, Staffan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
    Hellström, Pekka
    University Central Hospital, Oulu, Finland.
    Tasdemir, Ilker
    Central Hospital of Rogaland, Stavanger, Norway.
    Malmström, Per-Uno
    University Hospital Uppsala, Sweden.
    5-Year Outcome of a Randomized Prospective Study Comparing bacillus Calmette-Guerin with Epirubicin and Interferon-alpha 2b in Patients with T1 Bladder Cancer2014In: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 191, no 5, 1244-1249 p.Article in journal (Refereed)
    Abstract [en]

    Purpose: In a multicenter, prospectively randomized study we evaluated the 5-year outcomes of bacillus Calmette-Guerin alone compared to a combination of epirubicin and interferon-alpha 2b in the treatment of patients with T1 bladder cancer. Materials and Methods: Transurethral resection was followed by a second resection and bladder mapping. Stratification was for grade and carcinoma in situ. Followup entailed regular cystoscopy and cytology during the first 5 years. The end points assessed in this analysis were recurrence-free survival, time to treatment failure and progression, cancer specific survival and prognostic factors. Results: The study recruited 250 eligible patients. The 5-year recurrence-free survival rate was 38% in the combination arm and 59% in the bacillus Calmette-Guerin arm (p = 0.001). The corresponding rates for the other end points were not significantly different, as free of progression 78% and 77%, treatment failure 75% and 75%, and cancer specific survival 90% and 92%, respectively. The type of treatment, tumor size and tumor status at second resection were independent variables associated with recurrence. Concomitant carcinoma in situ was not predictive of failure of bacillus Calmette-Guerin therapy. An independent factor for treatment failure was remaining T1 stage at second resection. Conclusions: Bacillus Calmette-Guerin was more effective than the tested combination therapy. The currently recommended management with second resection and 3-week maintenance bacillus Calmette-Guerin entails a low risk of cancer specific death. More aggressive treatment in patients with infiltrative tumors at second resection might improve these results. In particular, concomitant carcinoma in situ was not a predictive factor for poor outcome after bacillus Calmette-Guerin therapy.

  • 2.
    Almer, Sven
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology . Linköping University, Faculty of Health Sciences.
    Hjortswang, Henrik
    Linköping University, Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology . Linköping University, Faculty of Health Sciences.
    Hindorf , U
    Lund University.
    6-Thioguanine therapy in Crohns disease-Observational data in Swedish patients2009In: Digestive and Liver Disease, ISSN 1590-8658, Vol. 41, no 3, 194-200 p.Article in journal (Refereed)
    Abstract [en]

    Background and aims: Adverse events (AE) leading to discontinuation or dose-reduction of thiopurine therapy (TP) occur in 9-28% of patients with inflammatory bowel disease. 6-Thioguanine (6-TG) has been proposed as an alternative treatment in patients intolerant for azathioprine (AZA), but some concerns have been raised about drug safety.

    Methods: We evaluated in a prospective manner the tolerance and efficacy of 6-TG in 23 Crohns disease (CD) patients (13 men, median age 41 (19-65) years) with prior intolerance (n = 18) or resistance (It = 5) to AZA and/or 6-mercaptopurine (6-MP). In addition, eight patients had tried mycophenolate mofetil. Seventeen patients (74%) had undergone intestinal resection, often several times.

    Results: Patients were treated with a median daily dose of 40 mg 6-TG (range 20-60) for 259 (15-2272) days. Seven of 13 patients (54%) with active disease went into remission after 8 (4-26) weeks. Sixteen patients (70%) experienced AE that lead to discontinuation (n=10) after 85 (15-451) days or dose reduction (n=6) after 78 (10-853) days. Ten of 18 patients (56%) with prior TP-intolerance discontinued 6-TG treatment due to AE compared to none of five patients with TP-resistance (p=0.046). Of 13 patients that tolerated 6-TG, eight discontinued the drug due to therapeutic failure (n=5) or safety concerns (n=3). Eight patients (35%) continued treatment beyond 12 months. There was no significant difference in maximum thioguanine nucleotide levels between patients with AE leading to discontinuation/dose reduction and patients without AE, 652 (99-2488) vs. 551 (392-1574) pmol/8 x 10(8) RBC; p=0.80.

    Conclusions: In this cohort of CD patients with severe disease failing traditional thiopurine treatment, a small fraction (22%) had long-term benefit of 6-TG-treatment. 6-TG therapy seems to offer a limited therapeutic gain for patients intolerant to both AZA and 6-MP and other treatment options should be considered.

  • 3. Dieperink, Willem
    et al.
    van der Horst, Iwan C C
    Nannenberg-Koops, Jaqueline W
    Brouwer, Henk W
    Jaarsma, T
    Nieuwland, Wybe
    Zijlstra, Felix
    Nijsten, Maarten W N
    A 64-year old man who sustained many episodes of acute cardiogenic pulmonary edema successfully treated with Boussignac continuous positive airway pressure: a case report.2007In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 119, no 2, 268-70 p.Article in journal (Refereed)
    Abstract [en]

    Continuous positive airway pressure (CPAP) is standard treatment for patients with acute cardiogenic pulmonary edema. We describe a patient who had 21 episodes of acute cardiogenic pulmonary edema due to very poor patient compliance. This 64-year old man had end-stage congestive heart failure based on systolic left ventricular dysfunction following two myocardial infarctions. In addition to routine medical treatment 15 episodes of pulmonary edema were successfully treated with Boussignac continuous positive airway pressure (BCPAP). The BCPAP system is a simple, disposable, FDA-approved device that delivers positive pressure without a ventilator. This extraordinary case underscores the utility of the BCPAP system to avoid repeated intubation and mechanical ventilation in patients with cardiogenic pulmonary edema.

  • 4.
    Imamura, Teruhiko
    et al.
    University of Tokyo, Japan .
    Kinugawa, Koichiro
    University of Tokyo, Japan .
    Kato, Naoko
    University of Tokyo, Japan .
    Minatsuki, Shun
    University of Tokyo, Japan .
    Muraoka, Hironori
    University of Tokyo, Japan .
    Inaba, Toshiro
    University of Tokyo, Japan .
    Maki, Hisataka
    University of Tokyo, Japan .
    Shiga, Taro
    University of Tokyo, Japan .
    Hatano, Masaru
    University of Tokyo, Japan .
    Hosoya, Yumiko
    University of Tokyo, Japan .
    Takahashi, Masao
    University of Tokyo, Japan .
    Yao, Atsushi
    University of Tokyo, Japan .
    Kyo, Shunei
    University of Tokyo, Japan .
    Ono, Minoru
    University of Tokyo, Japan .
    Komuro, Issei
    University of Tokyo, Japan .
    A case with recovery of response to tolvaptan associated with remission of acute kidney injury and increased urine osmolality2013In: International Heart Journal, ISSN 1349-2365, Vol. 54, no 2, 115-118 p.Article in journal (Refereed)
    Abstract [en]

    Tolvaptan (TLV), a vasopressin type 2 receptor antagonist, has been demonstrated to be effective in patients with decompensated heart failure (HF) refractory to incremental doses of diuretics, but the responsiveness has not always been predictable. We have recently proposed that urine osmolality (U-OSM) is a valuable parameter for the prediction of responses to TLV, because U-OSM reflects the activity of the collecting ducts, where TLV plays its unique role. Acute kidney injury (AKI) is often associated with severe tubular dysfunction, including the collecting ducts, and in such cases a response to TLV may not be expected. We here experienced a patient with HF and AKI in whom TLV was not effective during AKI. We also observed recovery of responsiveness to TLV along with remission of AKI as well as increased U-OSM later on. We believe that this is the first report on the reversibility of the TLV response in relation to U-OSM.

  • 5.
    Alehagen, Urban
    et al.
    Linköping University, Department of Medicine and Health Sciences, Cardiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Janzon, Magnus
    Linköping University, Department of Medicine and Health Sciences, Cardiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    A clinician’s experience of using the Cardiac Reader NT-proBNP point-of-care assay in a clinical setting2008In: European Journal of Heart Failure, ISSN 1388-9842, Vol. 10, no 3, 260-266 p.Article in journal (Refereed)
    Abstract [en]

    The evaluation of natriuretic peptides has become increasingly valuable in a clinical setting, where information is often needed promptly.

    Objectives: To compare the usefulness of the recently released Roche Cardiac Reader ® NT-proBNP assay against the Roche Elecsys® NT-proBNP laboratory system in a clinical setting.

    Design and Results: Blood samples from 440 patients admitted for acute coronary syndromes, worsening of heart failure, or as policlinic heart failure patients were evaluated. The relation between the assays was analysed and the diagnostic concordance calculated. A good correlation was found between the assays (r=0.96, 95% CI: 0.94-0.97) with a diagnostic concordance of 0.93. A separate analysis was performed in the range where most clinical decisions are made (60-3000 ng/L), with a diagnostic concordance of 88%. The usefulness in a clinical setting where time is important was high.

    Conclusion: The Roche Cardiac Reader® NT-proBNP assay has been evaluated in a clinical setting. The point-of-care method shows good results, although with a restricted analytical range compared with the reference.

  • 6.
    Ågren, Susanna
    et al.
    Linköping University, Department of Medicine and Health Sciences, Nursing Science. Linköping University, Faculty of Health Sciences.
    Evangelista, L
    n/a.
    Strömberg, Anna
    Linköping University, Department of Medicine and Health Sciences, Nursing Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    A comparative study addressing health-related quality of life, symptoms of depression, perceived control and knowledge in patients with heart failure and their partners.2009In: Esc congress, Barcelona, 2009Conference paper (Refereed)
  • 7.
    Gustavsson, Johan
    Linköping University, Department of Computer and Information Science, Software and Systems. Zenterio.
    A Comparative Study of Automated Test Explorers2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    With modern computer systems becoming more and more complicated, theimportance of rigorous testing to ensure the quality of the product increases.This, however, means that the cost to perform tests also increases. In orderto address this problem, a lot of research has been conducted during thelast years to find a more automated way of testing software systems. Inthis thesis, different algorithms to automatically explore and test a systemhave been implemented and evaluated. In addition to this, a second setof algorithms have been implemented with the objective to isolate whichinteractions with the system were responsible for a failure. These algorithmswere also evaluated and compared against each other. In the first evaluationtwo explorers, which I called DeBruijn and LStarExplorer, were consideredsuperior to the other. The first used a DeBruijn sequence to brute forcea solution while the second used the L*-algorithm to build an FSM overthe system under test. This FSM could then be used to provide a moreaccurate description for when the failure occurred. The result from thesecond evaluation were two reducers which both tried to recreate a failureby first applying interactions performed just before the failure occurred. Ifthis was not successful, they tried interactions further and further away, untilthe failure was triggered. In addition to this, the thesis contains descriptionsabout the framework used to run the different strategies.

  • 8.
    Thompson, M.S.
    et al.
    Center for Musculoskeletal Surgery, Charite-University of Medicine, Berlin, Germany.
    Flivik, G.
    Department of Orthopaedics, Lund University Hospital, Lund, Sweden.
    Juliusson, R.
    Department of Orthopaedics, Lund University Hospital, Lund, Sweden.
    Odgaard, A.
    Orthopaedic Research Laboratory, Aarhus University Hospital, Aarhus, Denmark.
    Ryd, Leif
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine .
    A comparison of structural and mechanical properties in cancellous bone from the femoral head and acetabulum2004In: Proceedings of the Institution of mechanical engineers. Part H, journal of engineering in medicine, ISSN 0954-4119, Vol. 218, no 6, 425-429 p.Article in journal (Refereed)
    Abstract [en]

    Mechanical interlock obtained by penetration of bone cement into cancellous bone is critical to the success of cemented total hip replacement (THR). Although acetabular component loosening is an important mode of THR failure, the properties of acetabular cancellous bone relevant to cement penetration are not well characterized. Bone biopsies (9 mm diameter, 10 mm long) were taken from the articular surfaces of the acetabulum and femoral head during total hip replacement. After mechanical and chemical defatting the two groups of bone specimens were characterized using flow measurement, mechanical testing and finally serial sectioning and three-dimensional computer reconstruction. The mean permeabilities of the acetabular group (1.064 × 10-10 m2) and femoral group (1.155 × 10-10 m2) were calculated from the flow measurements, which used saline solution and a static pressure of 9.8 kPa. The mean Young's modulus, measured non-destructively, was 47.4 MPa for the femoral group and 116.4 MPa for the acetabular group. Three-dimensional computer reconstruction of the specimens showed no significant differences in connectivity and porosity between the groups. Results obtained using femoral head cancellous bone to investigate bone cement penetration and fixation are directly relevant to fixation in the acetabulum. © IMechE 2004.

  • 9.
    Edlund, Ulf
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Mechanical Engineering, Engineering Mechanics.
    Volgers, Pieter
    A composite ply failure model based on continuum damage mechanics2004In: Composite structures, ISSN 0263-8223, Vol. 65, no 3-4, 347-355 p.Article in journal (Refereed)
    Abstract [en]

    A material model including the failure behaviour is derived for a thin unidirectional (UD) composite ply. The model is derived within a thermodynamic framework and the failure behaviour is modelled using continuum damage mechanics. The following features describe the model: (i) The ply is assumed to be in a plane state of stress. (ii) Three damage variables associated with the stress in the fibre-, transverse and shear directions, respectively, are used. (iii) The plastic behaviour of the matrix material is modelled. (iv) The difference in the material response in tensile and compressive loading is modelled. (v) Rate dependent behavior of plasticity and damage (i.e. strength) is modelled.

  • 10.
    Jonsson, Åsa
    et al.
    County Hospital Ryhov, Sweden.
    Hallberg, Ann-Charlotte
    Linköping University, Department of Computer and Information Science, Statistics. Linköping University, Faculty of Arts and Sciences.
    Edner, Magnus
    Karolinska University Hospital, Sweden.
    Lund, Lars H.
    Karolinska Institute, Sweden; Karolinska University Hospital, Sweden.
    Dahlström, Ulf
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Cardiology in Linköping.
    A comprehensive assessment of the association between anemia, clinical covariates and outcomes in a population-wide heart failure registry2016In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 211, 124-131 p.Article in journal (Refereed)
    Abstract [en]

    Background: The aim was to investigate the prevalence of, predictors of, and association with mortality and morbidity of anemia in a large unselected cohort of patients with heart failure (HF) and reduced ejection fraction (HFrEF) and to explore if there were specific subgroups of high risk. Methods: In patients with HFrEF in the Swedish Heart Failure Registry, we assessed hemoglobin levels and associations between baseline characteristics and anemia with logistic regression. Using propensity scores for anemia, we assessed the association between anemia and outcomes with Cox regression, and performed interaction and sub-group analyses. Results: There were 24 511 patients with HFrEF (8303 with anemia). Most important independent predictors of anemia were higher age, male gender and renal dysfunction. One-year survival was 75% with anemia vs. 81% without (p < 0.001). In the matched cohort after propensity score the hazard ratio associated with anemia was for all-cause death 1.34 (1.28-1.40; p < 0.0001), CV mortality 1.28 (1.20-1.36; p < 0.0001), and combined CV mortality or HF hospitalization 1.24 (1.18-1.30; p < 0.0001). In interaction analyses, anemia was associated with greater risk with lower age, male gender, EF 30-39%, and NYHA-class I-II. Conclusion: In HFrEF, anemia is associated with higher age, male gender and renal dysfunction and increased risk of mortality and morbidity. The influence of anemia on mortality was significantly greater in younger patients, in men, and in those with more stable HF. The clinical implication of these findings might be in the future to perform targeted treatment studies. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

  • 11.
    Johansson, Jonas
    et al.
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    Belov, Ilja
    Jönköping University, School of Engineering, Department of Mechanical Engineering, Jönköping.
    Johnson, Erland
    SP Technical Research Institute of Sweden, Borås, Sweden.
    Leisner, Peter
    SP Technical Research Institute of Sweden, Borås, Sweden.
    A computational method for evaluating the damage in a solder joint of an electronic package subjected to thermal loadsManuscript (preprint) (Other academic)
    Abstract [en]

    Purpose – The purpose of this paper is to introduce a novel computational method to evaluate damage accumulation in a solder joint of an electronic package, when exposed to operating temperature environment. A procedure to implement the method is suggested, and a discussion of the method and its possible applications is provided in the paper.

    Originality/value – The method enables increased accuracy in thermal fatigue life prediction of solder joints. Combined with other failure mechanisms, it may contribute to the accuracy of reliability assessment of electronic packages.

    Design/methodology/approach – Methodologically, interpolated response surfaces based on specially designed finite element simulation runs, are employed to compute a damage metric at regular time intervals of an operating temperature profile. The developed method has been evaluated on a finite-element model of a lead-free PBGA256 package, and accumulated creep strain energy density has been chosen as damage metric.

    Findings – The method has proven to be two orders of magnitude more computationally efficient compared to finite element simulation. A general agreement within 3% has been found between the results predicted with the new method, and finite element simulations when tested on a number of temperature profiles from an avionic application. The solder joint temperature ranges between +25°C and +75°C.

    Practical implications – The method can be implemented as part of reliability assessment of electronic packages in the design phase.

  • 12.
    Agnafors, Marcus
    Linköping University, Department of Culture and Communication. Linköping University, Faculty of Arts and Sciences.
    A Critical Comment on Collste2011In: Public Health Ethics, ISSN 1754-9973, E-ISSN 1754-9981, Vol. 4, no 2, 203-205 p.Article in journal (Other academic)
    Abstract [en]

    This article claims that the account of specification as a way to solve conflicts between rights, suggested by Göran Collste, is unsatisfactory. It is argued that specification is not a solution on its own, but is better described as a remedy in response to a political failure.

  • 13.
    Gremyr, Ida
    et al.
    Chalmers University of Technology, Göteborg, Sweden).
    Elg, Mattias
    Linköping University, Department of Management and Engineering, Quality Technology and Management. Linköping University, The Institute of Technology. Linköping University, HELIX Vinn Excellence Centre.
    A developmental view on implementation of quality management concepts2014In: International Journal of Quality and Service Sciences, ISSN 1756-669X, E-ISSN 1756-6703, Vol. 6, no 2/3, 143-154 p.Article in journal (Refereed)
    Abstract [en]

    Purpose – The purpose of this paper is to examine the value of a developmental learning view on implementation of quality management (QM) concepts. QM concepts are common in various organizations; some implement them smoothly, others struggle and sometimes even abandon the initiatives. What is then a successful implementation – is it the use a specific QM method as a standard problem solving approach, or is it that learning has occurred during implementation?

    Design/methodology/approach – The paper is based on an illustrative case study carried out at a hospital in western Sweden. The data have been collected through about 130 hours of participation in project work by the first author and through seven face-to-face interviews of about one hour each.

    Findings – It is shown that a Design for Six Sigma pilot project with a narrow view on implementation could be regarded as a failure, but it gave rise to much learning and new improved ways of working. Hence, it is argued that a developmental view on implementation can support learning by an emergent and experimental approach to implementation processes.

    Originality/value – Much research has been done on how to increase the success rate of implementations of QM initiatives, e.g. procedures to follow to reach an outcome where the new way of working is standard procedure. Less research has problematized the implementation process, questioning what a successful outcome of an implementation is.

  • 14.
    Gupta, M
    et al.
    University West, Trollhättan, Sweden.
    Eriksson, Robert
    Linköping University, Department of Management and Engineering, Engineering Materials. Linköping University, The Institute of Technology.
    Sand, U
    EDR Medeso, Västerås, Sweden.
    Nylén, P
    University West, Trollhättan, Sweden.
    A Diffusion-based Oxide Layer Growth Model Using Real Interface Roughness in Thermal Barrier Coatings for Lifetime Assessment2015In: Surface & Coatings Technology, ISSN 0257-8972, E-ISSN 1879-3347, Vol. 271, 181-191 p.Article in journal (Refereed)
    Abstract [en]

    The development of thermo-mechanical stresses during thermal cycling can lead to the formation of detrimental cracks in Atmospheric Plasma Sprayed (APS) Thermal Barrier Coatings systems (TBCs). These stresses are significantly increased by the formation of a Thermally Grown Oxide (TGO) layer that forms through the oxidation of mainly aluminium in the bondcoat layer of the TBC. As shown in previous work done by the authors, the topcoat–bondcoat interface roughness plays a major role in the development of the stress profile in the topcoat and significantly affects the lifetime of TBCs. This roughness profile varies as the TGO layer grows and changes the stress profile in the topcoat leading to crack propagation and thus failure.

    In this work, a two-dimensional TGO growth model is presented, based on oxygen and aluminium diffusion–reaction equations, using real interface profiles extracted from cross-section micrographs. The model was first validated by comparing the TGO profiles artificially created by the model to thermally cycled specimens with varying interface roughness. Thereafter, stress profiles in the TBC system, before and after the TGO layer growth, were estimated using a finite element modelling model described in previous work done by the authors. Three experimental specimens consisting of the same chemistry but with different topcoat–bondcoat interface roughness were studied by the models and the stress state was compared to the lifetimes measured experimentally. The combination of the two models described in this work was shown to be an effective approach to assess the stress behaviour and lifetime of TBCs in a comparative way.

  • 15.
    Kimita, Koji
    Department of System Design, Tokyo Metropolitan University, Tokyo, Japan.
    Shimomura, Yoshiki
    Department of System Design, Tokyo Metropolitan University, Tokyo, Japan.
    A Failure Analysis Method for Designing Highly Reliable Product-Service SystemsIn: Research in Engineering Design, ISSN 0934-9839, E-ISSN 1435-6066Article in journal (Refereed)
    Abstract [en]

    Recently, Product-Service Systems (PSSs), which create value by integrating a physical product and a service, have been attracting attention. In PSSs, it is critical for a provider to offer highly reliable products and services. To do so, the provider needs to effectively and efficiently detect possible failures, and then, take adequate measures against them in the conceptual design stage. However, in current studies on product failure analysis, service aspects are not covered in analyzing failure causes and developing measures. On the other hand, product aspects are hardly considered in existing methods of service failure analysis. To fill the gap, this paper proposes a method for failure analysis in PSS design called PSS Failure Mode and Effect Analysis (PSS FMEA). Especially, this paper extends the framework of FMEA, and then, a procedure for PSS FMEA is introduced so that designers can analyze failures and develop measures in consideration of both product and service aspects. Furthermore, the proposed method supports designers in finding new business opportunities. The proposed method was applied to a real offering of products and services by a cleaning machine provider and found effective.

  • 16.
    Kimita, Koji
    et al.
    Tokyo Metropolitan University, Japan.
    Sakao, Tomohiko
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Shimomura, Yoshiki
    Tokyo Metropolitan University, Japan.
    A failure analysis method for designing highly reliable product-service systems2017In: Research in Engineering Design, ISSN 0934-9839, E-ISSN 1435-6066Article in journal (Refereed)
    Abstract [en]

    Recently, product-service systems (PSSs), which create value by integrating a physical product and a service, have been attracting attention. In PSSs, it is critical for a provider to offer highly reliable products and services. To do so, the provider needs to effectively and efficiently detect possible failures, and then, take adequate measures against them in the conceptual design stage. However, in current studies on product failure analysis, service aspects are not covered in analyzing failure causes and developingmeasures. On the other hand, product aspects are hardly considered in existing methods of service failure analysis. To fill the gap, this paper proposes a method for failureanalysis in PSS design called PSS failure mode and effect analysis (PSS FMEA). Especially, this paper extends theframework of FMEA, and then, a procedure for PSS FMEA is introduced so that designers can analyze failures and develop measures in consideration of both product andservice aspects. Furthermore, the proposed method supports designers in finding new business opportunities. The proposed method was applied to a real offering of products and services by a cleaning machine provider and found effective.

  • 17.
    Lövborg, Henrik
    et al.
    Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pharmacology.
    Jönsson, Anna K
    Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pharmacology.
    Hägg, Staffan
    Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pharmacology.
    A fatal outcome after unintentional overdosing of rivastigmine patches2012In: Current drug safety, ISSN 2212-3911, Vol. 7, no 1, 30-32 p.Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Rivastigmine is an acetylcholine esterase inhibitor used in the treatment of dementia. Patches with rivastigmine for transdermal delivery have been used to increase compliance and to reduce side effects.

    CASE REPORT: We describe an 87-year old male with dementia treated with multiple rivastigmine patches (Exelon 9,5 mg/24 h) who developed nausea, vomiting and renal failure with disturbed electrolytes resulting in death. The symptoms occurred after six rivastigmine patches had concomitantly been erroneously applied by health care personnel on two consecutive days. The terminal cause of death was considered to be uremia from an acute tubular necrosis that was assessed as a result of dehydration through vomiting. The rivastigmine intoxication was assessed as having caused or contributed to the dehydrated condition. The medication error occurred at least partly due to ambiguous labeling. The clinical signs were not initially recognized as adverse effects of rivastigmine.

    DISCUSSION: The presented case is a description of a rivastigmine overdose due to a medication error involving patches. This case indicates the importance of clear and unambiguous instructions to avoid administration errors with patches and to be vigilant to adverse drug reactions for early detection and correction of drug administration errors. In particular, instructions clearly indicating that only one patch should be applied at a time are important.

  • 18.
    Schmidt, Peter
    et al.
    Linköping University, Department of Management and Engineering, Mechanics. Linköping University, The Institute of Technology.
    Edlund, Ulf
    Linköping University, Department of Management and Engineering, Mechanics. Linköping University, The Institute of Technology.
    A finite element method for failure analysis of adhesively bonded structures2010In: International Journal of Adhesion and Adhesives, ISSN 0143-7496, Vol. 30, no 8, 665-681 p.Article in journal (Refereed)
    Abstract [en]

    The solid bodies constituting the adhesively bonded joint, i.e. the adhesive and the adherends, are treated as material surfaces. The result can be regarded as a structural element model of the compound joint. The adhesive is modelled as a softening material due to local material damage. As a consequence, the propagation of a crack front in the adhesive layer can be followed, and the failure load of the structure becomes a computational result. A one-parameter viscous regularization of the softening adhesive material law is used in order to improve the numerical behavior. Several applications are presented

  • 19.
    Hadimeri, Henrik
    et al.
    Kärnsjukhuset, Skövde, Sweden.
    Frisenette-Fich, Carsten
    Ryhov, Jönköping, Sweden.
    Deurell, Sven-Ingemar
    Östergötlands Läns Landsting, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping.
    Svensson, Lars
    Höglandssjukhuset, Eksjö, Sweden.
    Carlsson-Bjering, Lena
    Höglandssjukhuset, Eksjö, Sweden.
    Fernström, Anders
    Linköping University, Department of Medical and Health Sciences, Nephrology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
    Almroth, Gabriel
    Linköping University, Department of Medicine and Care, Nephrology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
    Melander, Stefan
    Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
    Haarhaus, Mathias
    Linköping University, Department of Medicine and Care, Nephrology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
    Andersson, Per-Olof
    Östergötlands Läns Landsting, Local Health Care Services in East Östergötland, Department of Internal Medicine in Norrköping.
    Cassel, Agneta
    Östergötlands Läns Landsting, Heart and Medicine Center, Department of Nephrology.
    Mauritz, Nils-Johan
    Ryhov, Jönköping, Sweden.
    Ståhl-Nilsson, Agneta
    Ryhov, Jönköping, Sweden.
    Wilske, Jan
    Värnamo Sjukhus, Sweden .
    Nordström, Kataryna
    Värnamo Sjukhus, Sweden .
    Oruda, Pavel
    Värnamo Sjukhus, Sweden .
    Eriksson, Marie
    Umeå University, Sweden .
    Inghilesi Larsson, Annelie
    Umeå University, Sweden .
    Stegmayr, Bernd
    Umeå University, Sweden .
    A fixed protocol for outpatient clinic routines in the care of patients with severe renal failure2013In: Renal failure, ISSN 0886-022X, E-ISSN 1525-6049, Vol. 35, no 6, 845-854 p.Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    The primary aim of this study was to assess whether a fixed protocol, using a specially trained team, for intermediate follow-up to fulfillment of guideline targets is non-inferior to conventional follow-up in the care of uraemic patients. A secondary aim was to investigate possible impact on patient outcome.

    METHODS:

    The cohort comprised 424 patients from seven centers. Inclusion criteria were either serum creatinine exceeding 200 µmol/l or calculated clearance below 30 ml/min, representing CKD 4 or 5a. Six centers followed a standardized protocol (group 1). One center provided controls (group 2). The study design was prospective and interventional. The variables measured were blood hemoglobin, bicarbonate, calcium, phosphate, intact parathyroid hormone, albumin, renal function variables, blood pressure and RAAS blockade. The number of patients achieving the set goals was analyzed as a time trend to determine if the intervention resulted in an improvement.

    RESULTS:

    At baseline, group 1 had significantly lower GFR and higher serum creatinine, calcium, phosphate, calcium × phosphate product and bicarbonate, lower mean arterial pressure (MAP), systolic blood pressures and less use of RAAS. During the intervention, group 1 improved in the direction of guidelines for blood hemoglobin, albumin, bicarbonate and MAP. Outcome of secondary endpoints gave a risk of death of 30% in both groups, while the risk of renal replacement therapy was higher in group 1.

    CONCLUSIONS:

    However, the time to renal replacement therapy was significantly shorter in the intervention group, indicating that other variables than guideline achievements are important for the patient.

  • 20.
    Liu, Zhenxia
    et al.
    Linköping University, Department of Mathematics, Mathematical Statistics . Linköping University, Faculty of Science & Engineering.
    Yang, Xiangfeng
    Linköping University, Department of Mathematics, Mathematical Statistics . Linköping University, Faculty of Science & Engineering.
    A general large deviation principle for longest runs2016In: Statistics and Probability Letters, ISSN 0167-7152, E-ISSN 1879-2103, Vol. 110, 128-132 p.Article in journal (Refereed)
    Abstract [en]

    In this note we prove a general large deviation principle (LDP) for the longest success run in a sequence of independent Bernoulli trails. This study not only recovers several recently derived LDPs, but also gives new LDPs for the longest success run. The method is based on the Bryc’s inverse Varadhan lemma, which can be intuitively generalized to the longest success run in a two-state (success and failure) Markov chain.

  • 21.
    Nyman, Elin
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Brännmark, Cecilia
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Palmér, Robert
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Brugård, Jan
    MathCore Engn.
    Nyström, Fredrik
    Linköping University, Department of Medical and Health Sciences, Internal Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Centre, Department of Endocrinology and Gastroenterology UHL.
    Strålfors, Peter
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    Cedersund, Gunnar
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    A Hierarchical Whole-body Modeling Approach Elucidates the Link between in Vitro Insulin Signaling and in Vivo Glucose Homeostasis2011In: Journal of Biological Chemistry, ISSN 0021-9258, E-ISSN 1083-351X, Vol. 286, no 29, 26028-26041 p.Article in journal (Refereed)
    Abstract [en]

    Type 2 diabetes is a metabolic disease that profoundly affects energy homeostasis. The disease involves failure at several levels and subsystems and is characterized by insulin resistance in target cells and tissues (i.e. by impaired intracellular insulin signaling). We have previously used an iterative experimental-theoretical approach to unravel the early insulin signaling events in primary human adipocytes. That study, like most insulin signaling studies, is based on in vitro experimental examination of cells, and the in vivo relevance of such studies for human beings has not been systematically examined. Herein, we develop a hierarchical model of the adipose tissue, which links intracellular insulin control of glucose transport in human primary adipocytes with whole-body glucose homeostasis. An iterative approach between experiments and minimal modeling allowed us to conclude that it is not possible to scale up the experimentally determined glucose uptake by the isolated adipocytes to match the glucose uptake profile of the adipose tissue in vivo. However, a model that additionally includes insulin effects on blood flow in the adipose tissue and GLUT4 translocation due to cell handling can explain all data, but neither of these additions is sufficient independently. We also extend the minimal model to include hierarchical dynamic links to more detailed models (both to our own models and to those by others), which act as submodules that can be turned on or off. The resulting multilevel hierarchical model can merge detailed results on different subsystems into a coherent understanding of whole-body glucose homeostasis. This hierarchical modeling can potentially create bridges between other experimental model systems and the in vivo human situation and offers a framework for systematic evaluation of the physiological relevance of in vitro obtained molecular/cellular experimental data.

  • 22.
    Lundström, Erik
    et al.
    Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, The Institute of Technology.
    Simonsson, Kjell
    Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, The Institute of Technology.
    Gustafsson, David
    Linköping University, Department of Management and Engineering, Solid Mechanics. Linköping University, The Institute of Technology.
    Månsson, T.
    GKN Aerospace Engine Systems, Trollhättan, Sweden.
    A load history dependent model for fatigue crack propagation in Inconel 718 under hold time conditions2014In: Engineering Fracture Mechanics, ISSN 0013-7944, E-ISSN 1873-7315, Vol. 118, 17-30 p.Article in journal (Refereed)
    Abstract [en]

    Modelling of high temperature fatigue crack growth in Inconel 718 under the interaction of fast cyclic loading and hold times at maximum load has been conducted. A model, based on the concept of a damaged zone in front of the crack tip has been applied for three different temperatures, 550, 600 and 650 ◦C, with good agreement for both calibration and validation tests. A statistical evaluation of 22 tests in total was also conducted, which shows that the developed model gives a reasonable scatter factor at a probability of failure of 0.1 %.

  • 23.
    Kempe, Camilla
    et al.
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Educational Sciences.
    Gustafson, Stefan
    Linköping University, Department of Behavioural Sciences and Learning, Psychology. Linköping University, Faculty of Educational Sciences.
    Samuelsson, Stefan
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    A longitudinal study of early reading difficulties and subsequent problem behaviors2011In: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 52, no 3, 242-250 p.Article in journal (Refereed)
    Abstract [en]

    It is generally believed that early academic failure in school develops into a downward spiral of negative motivational and behavioral consequences. In this study, children with reading difficulties were compared with typical readers on questionnaires measuring ADHD symptoms and other behavior problems such as withdrawn symptoms, somatic complaints, anxiety/depression, social problems, and aggression. The results revealed that reading difficulties and problem behaviors appear more independent of each other rather than problem behaviors being a consequence of reading failure. In addition, gender differenceswere negligible when examining the relationship between reading difficulties and subsequent problem behavior. Some implications for special educationand intervention are suggested.

  • 24.
    Liljeroos, Maria
    et al.
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences.
    Ågren, Susanna
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences.
    Årested, Kristofer
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences.
    Jaarsma, Tiny
    Linköping University, Department of Social and Welfare Studies, Division of Health, Activity and Care. Linköping University, Faculty of Health Sciences.
    Strömberg, Anna
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Cardiology in Linköping.
    A long-term follow up of experiences of and factors influencing caregiver burden in partners of patients with heart failure2013Conference paper (Other academic)
  • 25.
    Svedjeholm, Rolf
    et al.
    Linköping University, Department of Medicine and Health Sciences, Thoracic Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery.
    Vidlund, Marten
    Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery. Linköping University, Faculty of Health Sciences.
    Vanhanen, Ingemar
    Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery. Linköping University, Faculty of Health Sciences.
    Hakanson, Erik
    Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery. Linköping University, Faculty of Health Sciences.
    A metabolic protective strategy could improve long-term survival in patients with LV-dysfunction undergoing CABG2010In: SCANDINAVIAN CARDIOVASCULAR JOURNAL, ISSN 1401-7431, Vol. 44, no 1, 45-58 p.Article in journal (Refereed)
    Abstract [en]

    Objective. Adverse outcome after CABG is closely related to postoperative heart failure precipitated by ischemia and myocardial infarction. Restrictive use of inotropes is therefore desirable. Patients with preoperative left ventricular dysfunction are a high-risk group in this respect. To reduce myocardial oxygen expenditure we evolved a metabolic strategy for perioperative care. Design. Observational study on 104 consecutive patients with severe left ventricular dysfunction undergoing CABG. The metabolic strategy implied physiological measures to minimize myocardial oxygen expenditure including restrictive use of inotropes and specific measures such as extended CPB and metabolic support to facilitate myocardial recovery. Hemodynamic state was primarily assessed by mixed venous oxygen saturation (SvO(2)). Follow-up averaged 9.7 +/- 1.4 years. Results. LVEF was 0.30 +/- 0.05 (range 0.20-0.37) and 3.5 +/- 1.3 vessels were bypassed. Inotropes were used in 6.7% for weaning from CPB. Increase of s-creatinine by andgt;= 50% compared to preoperative values was observed in 2.9%. Logistic EuroSCORE was 8.3% whereas observed 30-day mortality was 1.0%. Crude 5-year survival was 89.4%. Conclusions. The metabolic strategy allowed restrictive use of inotropes and was associated with encouraging long-term survival. Renal function was well preserved suggesting that SvO(2) served as an adequate marker of circulation. Randomized trials with metabolic support are warranted.

  • 26.
    Lönn, Urban
    Linköping University, Department of Medical and Health Sciences, Cardiothoracic Anaesthesia and Intensive care. Linköping University, Faculty of Health Sciences.
    A minimally invasive axial blood flow pump: an experimental and clinical study1997Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The first aim of this thesis was to evaluate a new minimally invasive axial blood flow pump for treatment of patients needing circulatory support after open heart surgery. This system, the Hemopump temporary cardiac assist device, is a very small catheter mounted intracorporeal pump, which is introduced transvalvularly into the left ventricle. The pump can be inserted either through the femoral artery or directly through a graft sutured to the ascending aorta. In an experimental model, the flow capacity of three different designs of the system was investigated. Flow capacity varied between 2.0 and 4.5 liters per minute, depending on the working conditions for the different pump models. Twenty,four patients were treated for post,cardiotomy heart failure. Fourteen patients (58 %) were weaned from the device and later discharged from the hospital. In a subgroup of these patients (54%) where early intervention was instituted, the survival rate was 85%. The pump proved to be an effective tool for unloading a failing left ventricle with preservation of multi-organ perfusion. A clinical protocol was established for postoperative management. The Hemopump was easy to adapt to the clinical setting, and device~ related complications were few.

    The second aim was to develop a new less invasive procedure for CABG, avoiding the need for cardio~pulmonary bypass during these procedures. First an animal trial was performed as a feasibility study. In combination with the administration of a short~acting ~~blocker, esmolol, this method enabled precise coronary bypass surgery. When results became consistent a small pilot study was done on five patients showing that this was a reproducible technique. Finally a prospective randomized trial comparing this technique with conventional bypass surgery was carried out. The Hemopump supported bypass surgery did not prolong the procedure, did not require a longer time on circulatory support and bleeding was less. Postoperative enzyme levels indicated that ischemic insult to the myocardium was less than with conventional surgery.

    In summary, this minimally invasive axial blood flow pump proved to be a powerful left ventricular assist system enabling a less invasive approach during conditions where circulatory support is needed.

  • 27.
    Edlund, Ulf
    et al.
    Linköping University, Department of Management and Engineering, Mechanics . Linköping University, The Institute of Technology.
    Schmidt, Peter
    Linköping University, Department of Management and Engineering, Mechanics . Linköping University, The Institute of Technology.
    Roguet , E
    ENSMA, France.
    A model of an adhesively bonded joint with elastic-plastic adherends and a softening adhesive2009In: Computer Methods in Applied Mechanics and Engineering, ISSN 0045-7825, Vol. 198, no 5-8, 740-752 p.Article in journal (Refereed)
    Abstract [en]

    This paper deals with the generalization of a model of an adhesively bonded joint with the aim to allow elastic-plastic adherends. In the model of the joint that we extend, the thinness of the bodies and the low Youngs modulus of the adhesive were used to obtain a simplified model where the parts are described as material surfaces. We formulate an elastic-plastic material model with isotropic hardening expressed in the generalized stress and strain measures used for the surface description of the joint. The finite element formulation and the numerical treatment of the constitutive law are discussed. Numerical results showing the accuracy of the proposed treatment of the adherends are presented. Two failure load computations, using a softening material model for the adhesive, are presented and compared with experiments. The results show the importance of taking into account potential plastic deformations in the adherends in failure load computations.

  • 28.
    Askvid, Per
    Linköping University, Department of Computer and Information Science.
    A Model-Based Approach for Reliability Prediction2010Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    When developing products, reliability is an important factor that has to be considered. For safety critical systems it is important to know the probability that an item will perform a required function without failure under stated conditions for a stated period of time. The main goal of a reliability prediction analysis is to predict the rate at which the product of a system will fail. To perform this prediction there are a number of methodologies available.

    This Master Thesis proposes a model-based approach for reliability prediction calculations based on the physics of failure and supported by analysis of test-data field returns and physical models provided by the FIDES methodology. FIDES based reliability models have been integrated into a model-based diagnosis environment for seamless integration with other safety assessment analysis.

    The model-based diagnosis environment used in this thesis is model-based reasoner RODON developed by Uptime Solutions AB. Components that uses the FIDES methodology have been developed in RODON, where components can be combined to systems by drag and drop method. Usage profiles that are defined according to the FIDES methodology in RODON are not system specific, which makes them reusable in other systems. The developed library of components and usage profiles makes it easy to model complex systems and perform reliability predictions according to the FIDES methodology.

  • 29.
    Hagger, Martin S.
    et al.
    Curtin University, Australia.
    Chatzisarantis, Nikos L. D.
    Curtin University, Australia.
    Tinghög, Gustav (Contributor)
    Linköping University, Department of Management and Engineering, Economics. Linköping University, Faculty of Arts and Sciences.
    A multilab preregistered replication of the ego-depletion effect2016In: Perspectives on Psychological Science, ISSN 1745-6916, E-ISSN 1745-6924, Vol. 11, no 4, 546-573 p.Article in journal (Refereed)
    Abstract [en]

    Good self-control has been linked to adaptive outcomes such as better health, cohesive personal relationships, success in the workplace and at school, and less susceptibility to crime and addictions. In contrast, self-control failure is linked to maladaptive outcomes. Understanding the mechanisms by which self-control predicts behavior may assist in promoting better regulation and outcomes. A popular approach to understanding self-control is the strength or resource depletion model. Self-control is conceptualized as a limited resource that becomes depleted after a period of exertion resulting in self-control failure. The model has typically been tested using a sequential-task experimental paradigm, in which people completing an initial self-control task have reduced self-control capacity and poorer performance on a subsequent task, a state known as ego depletion. Although a meta-analysis of ego-depletion experiments found a medium-sized effect, subsequent meta-analyses have questioned the size and existence of the effect and identified instances of possible bias. The analyses served as a catalyst for the current Registered Replication Report of the ego-depletion effect. Multiple laboratories (k = 23, total N = 2,141) conducted replications of a standardized ego-depletion protocol based on a sequential-task paradigm by Sripada et al. Meta-analysis of the studies revealed that the size of the ego-depletion effect was small with 95% confidence intervals (CIs) that encompassed zero (d = 0.04, 95% CI [−0.07, 0.15]. We discuss implications of the findings for the ego-depletion effect and the resource depletion model of self-control. 

  • 30.
    Schmidt, Peter
    et al.
    Linköping University, Department of Management and Engineering, Mechanics . Linköping University, The Institute of Technology.
    Edlund, Ulf
    Linköping University, Department of Management and Engineering, Mechanics . Linköping University, The Institute of Technology.
    A Multi-Layer Finite Element Method for Analysis of Adhesively Bonded Composite Laminates with Interlaminar Failure.: NFFP-KEKS Report WP2.2: Deliverables 2.2-32009Report (Other academic)
  • 31.
    Eriksson, Björn
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems.
    Larsson, Jonas
    Linköping University, The Institute of Technology. Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems.
    Palmberg, Jan-Ove
    Linköping University, The Institute of Technology. Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems.
    A Novel Valve Concept Including the Valvistor Poppet Valve2008In: Ventil : revija za fluidno tehniko in avtomatizacijo, ISSN 1318-7279, Vol. 14, no 5, 433-442 p.Article in journal (Other academic)
    Abstract [en]

    These days, energy efficient mobile fluid power systems are of great interest. A mobile system containing several different cylinder drives supplied with a single load sensing pump (LS-pump) has a number of advantages as well as disadvantages. One of the main advantages is the need of only one system pump. This makes the fluid power system compact and cost-effective. A challenge is to keep the hydraulic losses at low level, especially losses at smaller loads. This paper introduces a fail-safe proportional valve element that is based on the Valvistor poppet valve. Due to the demands of flexibility the poppet valve is bi-directional. The valve has an innovative hydro-mechanical layout that makes it fail-safe, unwanted lowering loads, for example, never occur. The new valve includes simple sensors that are suitable for identification of mode switches, e g between normal, differential and regenerative modes. It is also possible to maneuver the system with maintainted velocity control in the case of sensor failure. In a less complex system the concept has benefits as well. For example in systems where fail-safe-bi-directional on/off valves are needed, then without mode sensing capabilities.

  • 32.
    Eriksson, Björn
    et al.
    Linköping University, Department of Management and Engineering, Fluid and Mechanical Engineering Systems . Linköping University, The Institute of Technology.
    Larsson, Jonas
    Linköping University, Department of Management and Engineering. Linköping University, The Institute of Technology.
    Palmberg, Jan-Ove
    Linköping University, Department of Management and Engineering, Fluid and Mechanical Engineering Systems . Linköping University, The Institute of Technology.
    A Novel Valve Concept Including the Valvistor Poppet Valve2007In: The Tenth Scandinavian International Conference on Fluid Power / [ed] J. Vilenius and K. T. Koskinen, Tampere, Finland: Tampere University of Technology , 2007, 355-364 p.Conference paper (Refereed)
    Abstract [en]

    These days, energy efficient mobile fluid power systems are of great interest. A mobile system containing several different cylinder drives supplied with a single load sensing pump (LS-pump) has a number of advantages as well as disadvantages. One fo the main advantages is the need of only one system pump. This makes the fluid power system compact and cost-effective. A challenge is to keep the hydraulic losses at a low level, especially losses at smaller loads. This paper introduces a fail-safe proportional valve element that is based on the Valvistor poppet valve. Due to the demands of flexibility the poppet valve is bi-directional. The valve has an innovative hydro-mechanic layout that makes it fail-safe, unwanted lowering loads, for example, never occur. The new valve includes simple sensors that are suitable for identificaiton of mode switches, e g between normal, differential and regenerative modes. It is also possible to manoevre the system with maintained velocity control in case of sensor failure. In a less complex system the concept has benefits as well. For example in systems where fail-safe bi-directional on/off valves are needed, then without mode sensing capabilities.

  • 33.
    Björnsson, Bergthor
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
    Lundgren, L
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
    A Personal Computer Freeware as a Tool for Surgeons to Plan Liver Resections.2016In: Scandinavian Journal of Surgery, ISSN 1457-4969, E-ISSN 1799-7267, Vol. 105, no 3, 153-157 p.Article in journal (Refereed)
    Abstract [en]

    BACKGROUND AND AIMS: The increase in liver surgery and the proportion of resections done on the margin to postoperative liver failure make preoperative calculations regarding liver volume important. Earlier studies have shown good correlation between calculations done with ImageJ and specimen weight as well as volume calculations done with more robust systems. The correlation to actual volumes of resected liver tissue has not been investigated, and this was the aim of this study.

    MATERIAL AND METHODS: A total of 30 patients undergoing well-defined liver resections were included in this study. Volumes calculated with ImageJ were compared to volume measurements done after the retrieval of resected liver tissue.

    RESULTS AND CONCLUSIONS: A strong correlation between calculated and measured liver volume was found with sample concordance correlation coefficient (ρc) = 0.9950. The knowledge on the nature of liver resections sets liver surgeons in a unique position to be able to accurately predict the volumes to be resected and, therefore, also the volume that will remain after surgery. This becomes increasingly important with the evolvement of methods to extend the boundaries of liver surgery. ImageJ is a reliable tool to preoperatively assess liver volume.

  • 34.
    Olsson, Anders
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Internal Medicine. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
    Casciano, Roman
    USA.
    Stern, Lee
    USA.
    Svengren, Per
    Pfizer, Sverige.
    A pharmacoeconomic evaluation of aggressive cholesterol lowering in Sweden2004In: International Journal of Cardiology, ISSN 0167-5273, Vol. 96, no 1, 51-57 p.Article in journal (Refereed)
    Abstract [en]

    Objective: To estimate the short-term healthcare costs and incremental cost per event avoided, associated with aggressive atorvastatin treatment in patients with acute coronary syndrome in Sweden. Methods: The total expected 16-week healthcare costs per patient on atorvastatin 80 mg per day and placebo were compared using clinical outcomes data from The Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) study and Swedish cost data sources. The incremental cost per event avoided was also assessed for. The clinical outcomes measured in this pharmacoeconomic analysis included: death, cardiac arrest, non-fatal myocardial infarction, fatal myocardial infarction, angina pectoris, non-fatal stroke, congestive heart failure, and surgical or percutaneous coronary revascularizations. All direct medical costs were taken into account. Results: The probability of the occurrence of an event was 40.4% per patient in the placebo cohort and 36.6% per patient in the atorvastatin cohort. The total expected cost per patient was SEK 17,887 (1950. 21€11 EUR=9.17231 SEK.) in the placebo group and SEK 18,465 (2013.06€) in the atorvastatin group, resulting in an incremental cost of SEK 578 (63.0137€) per patient. The cost per event avoided was SEK 15,076 (1643.64€). Sixty six percent of the cost of atorvastatin treatment was offset by the cost savings obtained through the reduction in the number of events in the atorvastatin group compared to the placebo group. Conclusions: In Sweden, the clinical benefits of aggressive short-term atorvastatin treatment administered within a few days after acute coronary syndrome is associated with a substantial hospitalization cost offset secondary to the clinical benefits of atorvastatin. © 2003 Elsevier Ireland Ltd. All rights reserved.

  • 35.
    Samuelsson, J.
    et al.
    Department of Medicine, Stockholm South Hospital, Stockholm, Sweden, Department of Medicine, Stockholm South Hospital, Karolinska Institute, S-118 83 Stockholm, Sweden.
    Hasselbalch, H.
    Department of Medicine, Roskilde University Hospital, Roskilde, Denmark.
    Bruserud, O.
    Department of Hematology, Haukeland University Hospital, Bergen, Norway.
    Temerinac, S.
    Department of Experimental Anesthesiology, University Hospital Freiburg, Freiburg, Germany.
    Brandberg, Y.
    Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
    Merup, M.
    Hematology Center, Karolinska University Hospital, Stockholm, Sweden.
    Linder, O.
    Department of Medicine, University Hospital, Orebro, Sweden.
    Bjorkholm, M.
    Hematology Center, Karolinska University Hospital, Stockholm, Sweden.
    Pahl, H.L.
    Department of Experimental Anesthesiology, University Hospital Freiburg, Freiburg, Germany.
    Birgegard, G.
    Department of Medicine, University Hospital, Uppsala, Sweden.
    Ghanima, W.
    Department of Medicine, Ostfold-Fredriksstads Hospital, Fredriksstad, Norway.
    Gram-Hansen, P.
    Department of Hematology, Odense University Hospital, Odense, Denmark.
    Johansson, P.
    Department of Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Malm, C.
    Department of Hematology, University Hospital, Linkoping, Sweden.
    Markevam, B.
    Department of Medicine, University Hospital, Umea, Sweden.
    Mourits-Andersen, T.
    Department of Medicine, Esbjerg Hospital, Esbjerg, Denmark.
    Nillson, L.
    Department of Hematology, Lund University Hospital, Lund, Sweden.
    A phase II trial of pegylated interferon a-2b therapy for polycythemia vera and essential thrombocythemia: Feasibility, clinical and biologic effects, and impact on quality of life2006In: Cancer, ISSN 0008-543X, Vol. 106, no 11, 2397-2405 p.Article in journal (Refereed)
    Abstract [en]

    BACKGROUND. Conventional interferon-a (IFN) is an effective treatment for patients with myeloproliferative disorders. However, many patients discontinue therapy because of side effects. METHODS. In this 24-month, Phase II feasibility study of pegylated interferon a-2b (PEG-IFN) treatment, a starting dose of 0.5 µg/kg per week was received by 21 patients with polycythemia vera (PV) and 21 patients with essential thrombocythemia (ET). The treatment objective, a complete platelet response (CR), was a platelet count <400 × 109/L in symptomatic patients and <600 in asymptomatic patients. Neutrophil polycythemia rubra vera-1 (PRV-1) messenger RNA expression was analyzed prior to and during therapy. Quality of life (QoL) was investi-gated by using the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire. RESULTS. At 6 months, 29 of 42 patients (69%) had achieved a CR after a median of 83 days. The CR rate was not related to diagnosis, gender, or previous therapy. Nineteen patients completed the planned 2-year treatment in CR. No thromboembolic or bleeding complications were observed. Phlebotomy requirements were reduced in the majority of patients with PV. Five of 14 patients (36%) who initially were positive for PRV-1 achieved normalized PRV-1 expression under PEG-IFN treatment. Side effects were the cause of therapy failure in 16 of 23 patients. However, only 8 of 19 patients reported any side effects at 2 years. The QLQ-C30 revealed clinically significant impairments in several aspects of QoL at 6 months, however, at 2 years, QoL measurements were not different from baseline. CONCLUSIONS. PEG-IFN effectively reduced platelet counts in 29 of 42 patients, but only 19 patients maintained a CR at 2 years. The reversal of PRV-1 positivity noted in a subset of patients suggested that PEG-IFN may have an effect on the malignant clone. PEG-IFN is a valuable therapeutic alternative for patients who tolerate its initial side effects. © 2006 American Cancer Society.

  • 36. Gruber, A
    et al.
    Björkholm, M
    Brinch, L
    Evensen, S
    Gustavsson, B
    Hedenus, M
    Juliusson, Gunnar
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Hematology. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Haematology UHL.
    Lofvenberg, E
    Nesthus, I
    Simonsson, B
    Sjö, M
    Stenke, L
    Tangen, JM
    Tidefelt, U
    Uden, AM
    Paul, C
    Liliemark, J
    A phase I/II study of the MDR modulator Valspodar (PSC 833) combined with daunorubicin and cytarabine in patients with relapsed and primary refractory acute myeloid leukemia2003In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, Vol. 27, no 4, 323-328 p.Article in journal (Refereed)
    Abstract [en]

    The cyclosporine analog Valspodar (PSC 833, Novartis Pharma) is a strong inhibitor of the mdr1 gene product p-glycoprotein (pgp). A phase I/II study was conducted in order to evaluate if addition of Valspodar to treatment with daunorubicin and cytarabine, given to patients with primary refractory or relapsed acute myeloid leukemia, could increase the complete remission rate. Fifty-three patients were treated in cohorts of three to six patients. Twelve patients reached a complete remission in bone marrow, five of whom also normalized their peripheral blood values. Three patients experienced treatment-related deaths from pneumonia, liver failure and cerebral hemorrhage, respectively. It is concluded that Valspodar 10mg/kg per 24h in combination with daunorubicin 45mg/m2 for 3 days and cytarabine 1g/m2 twice daily for 4 days is tolerable in this heavily pre-treated group of patients. Due to the moderate treatment results, the phase II part of the study was ended prematurely. The modulation of only pgp did not give an obvious improvement of the treatment results in this group of patients. ⌐ 2002 Elsevier Science Ltd. All rights reserved.

  • 37.
    Hult, Peter
    et al.
    Linköping University, Department of Biomedical Engineering, Physiological Measurements. Linköping University, The Institute of Technology.
    Oscarsson, Marcus
    Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
    Rattfält, Linda
    Linköping University, Department of Biomedical Engineering, Physiological Measurements. Linköping University, The Institute of Technology.
    Ask, Per
    Linköping University, Department of Biomedical Engineering, Physiological Measurements. Linköping University, The Institute of Technology.
    A platform for patient monitoring in home health care including an interpretation tool for heart failure patients2009In: WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, VOL 25, PT 5, ISSN 1680-0737, Vol. 25, no 5, 157-160 p.Article in journal (Refereed)
    Abstract [en]

    About 2% of the population suffer from heart failure, which is a disease associated with high mortality. We have developed a measurement platform including an interpretation tool for heart failure patients where physiological signals can be acquired and on which signal analysis techniques can be implemented. The platform can also be used to store patient data, to enable comparison over time and invoke distance consultation if necessary. In this platform, we have implemented a tool for interpretation support of the data measured from the patient. This tool are intended for use in home health care as an aid for monitoring and follow up heart failure patients.

  • 38.
    Danelljan, Martin
    et al.
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, Faculty of Science & Engineering.
    Meneghetti, Giulia
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, Faculty of Science & Engineering.
    Khan, Fahad
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, Faculty of Science & Engineering.
    Felsberg, Michael
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, Faculty of Science & Engineering.
    A Probabilistic Framework for Color-Based Point Set Registration2016In: 2016 IEEE CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION (CPVR), IEEE , 2016, 1818-1826 p.Conference paper (Refereed)
    Abstract [en]

    In recent years, sensors capable of measuring both color and depth information have become increasingly popular. Despite the abundance of colored point set data, state-of-the-art probabilistic registration techniques ignore the available color information. In this paper, we propose a probabilistic point set registration framework that exploits available color information associated with the points. Our method is based on a model of the joint distribution of 3D-point observations and their color information. The proposed model captures discriminative color information, while being computationally efficient. We derive an EM algorithm for jointly estimating the model parameters and the relative transformations. Comprehensive experiments are performed on the Stanford Lounge dataset, captured by an RGB-D camera, and two point sets captured by a Lidar sensor. Our results demonstrate a significant gain in robustness and accuracy when incorporating color information. On the Stanford Lounge dataset, our approach achieves a relative reduction of the failure rate by 78% compared to the baseline. Furthermore, our proposed model outperforms standard strategies for combining color and 3D-point information, leading to state-of-the-art results.

  • 39.
    Wilk, Artur
    et al.
    Linköping University, Department of Computer and Information Science, TCSLAB - Theoretical Computer Science Laboratory. Linköping University, The Institute of Technology.
    Drabent, Wlodzimierz
    Linköping University, Department of Computer and Information Science, TCSLAB - Theoretical Computer Science Laboratory. Linköping University, The Institute of Technology.
    A prototype of a descriptive type system for Xcerpt2006In: Principles and Practice of Semantic Web Reasoning: 4th International Workshop, PPSWR 2006, Budva, Montenegro, June 10-11, 2006, Revised Selected Papers / [ed] Jóse Júlio Alferes, James Bailey, Wolfgang May and Uta Schwertel, Springer Berlin/Heidelberg, 2006, Vol. 4187, 262-275 p.Chapter in book (Refereed)
    Abstract [en]

    The paper presents a prototype implementation of a descriptive type system for the XML query language Xcerpt. Its intended application is finding (a certain kind of) errors in programs. The implementation is able to check correctness of an Xcerpt program with respect to a type specification. A type specification describes a set of possible data bases to which the program is to be applied and an expected set of results. Program correctness means that all its results are in the expected set. Failure of a correctness check suggests an error in the program. Under certain conditions such failure indeed means that the program is incorrect. Current implementation works for a restricted, but interesting subset of Xcerpt. The system provides (approximations of) the set of program results and the sets of values of program variables, this information is useful for programmers (and is produced even when the specification of the expected set of results is not given).

  • 40.
    Wilk, Artur
    et al.
    Linköping University, Department of Computer and Information Science, TCSLAB - Theoretical Computer Science Laboratory. Linköping University, The Institute of Technology.
    Drabent, Włodzimierz
    Linköping University, Department of Computer and Information Science, TCSLAB - Theoretical Computer Science Laboratory. Linköping University, The Institute of Technology.
    A prototype of a descriptive type system for Xcerpt2006In: Proceedings of the Fourth Workshop on Principles and Practice of Semantic Web Reasoning. Budva, Montenegro, 2006, Vol. LNCS 4187, 262-275 p.Conference paper (Refereed)
    Abstract [en]

    The paper presents a prototype implementation of a descriptive type system for the XML query language Xcerpt. Its intended application is finding (a certain kind of) errors in programs. The implementation is able to check correctness of an Xcerpt program with respect to a type specification. A type specification describes a set of possible data bases to which the program is to be applied and an expected set of results. Program correctness means that all its results are in the expected set. Failure of a correctness check suggests an error in the program. Under certain conditions such failure indeed means that the program is incorrect.

    Current implementation works for a restricted, but interesting subset of Xcerpt. The system provides (approximations of) the set of program results and the sets of values of program variables; this information is useful for programmers (and is produced even when the specification of the expected set of results is not given).

  • 41.
    Årestedt, Kristofer
    et al.
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences. Linnaeus University, Kalmar, Sweden .
    Ågren, Susanna
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Thoracic and Vascular Surgery.
    Flemme, Inger
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences.
    Moser, Debra K
    University Kentucky, Lexington, KY, USA.
    Strömberg, Anna
    Linköping University, Department of Medical and Health Sciences, Division of Nursing Science. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Cardiology in Linköping.
    A psychometric evaluation of the four-item version of the Control Attitudes Scale for patients with cardiac disease and their partners2015In: European Journal of Cardiovascular Nursing, ISSN 1873-1953, E-ISSN 1474-5151, Vol. 14, no 4, 317-325 p.Article in journal (Refereed)
    Abstract [en]

    Background:The four-item Control Attitudes Scale (CAS) was developed to measure control perceived by patients with cardiac disease and their family members, but extensive psychometric evaluation has not been performed.Objective:The aim was to translate, culturally adapt and psychometrically evaluate the CAS in a Swedish sample of implantable cardioverter defibrillator (ICD) recipients, heart failure (HF) patients and their partners.Methods:A sample (n=391) of ICD recipients, HF patients and partners were used. Descriptive statistics, item-total and inter-item correlations, exploratory factor analysis, ordinal regression modelling and Cronbach's alpha were used to validate the CAS.Results:The findings from the factor analyses revealed that the CAS is a multidimensional scale including two factors, Control and Helplessness. The internal consistency was satisfactory for all scales (α=0.74-0.85), except the family version total scale (α=0.62). No differential item functioning was detected which implies that the CAS can be used to make invariant comparisons between groups of different age and sex.Conclusions:The psychometric properties, together with the simple and short format of the CAS, make it to a useful tool for measuring perceived control among patients with cardiac diseases and their family members. When using the CAS, subscale scores should be preferred.

  • 42.
    Karlsson, Magnus
    Linköping University, Department of Mechanical Engineering, Energy Systems. Linköping University, The Institute of Technology.
    A pulp and paper mill in the deregulated electricity market: strategies for electricity productionManuscript (preprint) (Other academic)
    Abstract [en]

    The deregulated electricity market has changed the prerequisites for the different actors in the market, both electricity producing companies and electricity purchasers. Companies may purchase electricity directly on the spot market and/ or use different derivatives, such as forwards and futures, as hedging instruments. There are various strategies for acting in the market and this paper explores alternative strategies for a Swedish board mill where hedging contracts to secure the price of electricity cover part of the electricity demand. The remaining demand is purchased on the spot market or produced on site. The back-pressure turbines on site are subject to possible changes in order to determine whether it is profitable to make additional investments aimed at reducing costs.

    Producing electricity close to the demand is a favourable alternative due to reduced losses in the grid and a lesser risk of power failure. Using back-pressure turbines on site meets these requirements and may also help to reduce the risk of power shortages. In certain situations, offering electricity production when there is a lack of electric power in the national grid is a possible alternative aimed at increasing income.

    The result shows that the choice of hedging strategy strongly influences the possibility of reducing costs. It is also shown that the different hedging strategies depend on factors such as the amount of electricity produced on site and the spot price.

  • 43.
    Schoemaker, N.E.
    et al.
    Antoni Van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, Netherlands, Slotervaart Hospital, Amsterdam, Netherlands.
    Kuppens, I.E.L.M.
    Antoni Van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, Netherlands, Slotervaart Hospital, Amsterdam, Netherlands, Dept. of Pharmacy and Pharmacology, Slotervaart Hospital, The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, Netherlands.
    Moiseyenko, V.
    Petrov Res. Institute of Oncology, St-Petersburg, Russian Federation.
    Glimelius, B.
    Onkologiska Kliniken, Uppsala, Sweden.
    Kjaer, M.
    Aalborg Hospital, Aalborg, Denmark.
    Starkhammer, H.
    Onkologiska Kliniken, Linkoping, Sweden.
    Richel, D.J.
    Medisch Spectrum Twente, Enschede, Netherlands.
    Smaaland, R.
    Haukeland Hospital, Bergen, Norway.
    Bertelsen, K.
    Odense University Hospital, Odense, Denmark.
    Poulsen, J.P.
    Norwegian Radium Hospital, Oslo, Norway.
    Voznyi, E.
    Res. Inst. of Diagnostic and Surgery, Moscow, Russian Federation.
    Norum, J.
    Regional Hospital of Tromso, Tromso, Norway.
    Fennelly, D.
    St. Vincent Hospital, Dublin, Ireland.
    Tveit, K.M.
    Ullevaal University Hospital, Oslo, Norway.
    Garin, A.
    All-Union Cancer Research Center, Moscow, Russian Federation.
    Gruia, G.
    Aventis Pharma, Antony Cedex, France.
    Mourier, A.
    Aventis Pharma, Antony Cedex, France.
    Sibaud, D.
    Aventis Pharma, Antony Cedex, France.
    Lefebvre, P.
    Aventis Pharma, Antony Cedex, France.
    Beijnen, J.H.
    Antoni Van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, Netherlands, Slotervaart Hospital, Amsterdam, Netherlands, Utrecht University, Faculty of Pharmaceutical Sciences, Netherlands.
    Schellens, J.H.M.
    Antoni Van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, Netherlands, Utrecht University, Faculty of Pharmaceutical Sciences, Netherlands.
    Ten, Bokkel Huinink W.W.
    Ten Bokkel Huinink, W.W., Antoni Van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, Netherlands.
    A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer2004In: British Journal of Cancer, ISSN 0007-0920, Vol. 91, no 8, 1434-1441 p.Article in journal (Refereed)
    Abstract [en]

    The purpose of this phase II trial was to compare the efficacy, safety and pharmacokinetics of four irinotecan schedules for the treatment of metastatic colorectal cancer. In total, 174 5-fluorouracil pretreated patients were randomised to: arm A (n = 41), 350 mg m-2 irinotecan as a 90-min i.v. infusion q3 weeks, arm B (n = 38), 125 mg m-2 irinotecan as a 90-min i.v. infusion weekly x 4 weeks q6 weeks, arm C (n = 46), 250 mg m-2 irinotecan as a 90-min i.v. infusion q2 weeks, or arm D (n = 49), 10 mg m -2 day-1 irinotecan as a 14-day continuous infusion q3 weeks. No significant differences in efficacy across the four arms were observed, although a shorter time to treatment failure was noted for arm D (1.7 months, P = 0.02). Overall response rates were in the range 5-11%. Secondary end points included median survival (6.4-9.4 months), and time to progression (2.7-3.8 months) and treatment failure (1.7-3.2 months). Similarly, there were no significant differences in the incidence of grade 3-4 toxicities, although the toxicity profile between arms A, B, and C and D did differ. Generally, significantly less haematologic toxicity, alopecia and cholinergic syndrome were observed in arm D, however, there was a trend for increased gastrointestinal toxicity. Irinotecan is an effective and safe second-line treatment for colorectal cancer. The schedules examined yielded equivalent results, indicating that there is no advantage of the prolonged vs short infusion schedules. © 2004 Cancer Research UK.

  • 44.
    Dittrich, Christian
    et al.
    Kaiser Franz Josef Spital, Austria Kaiser Franz Josef Spital, Austria .
    Papai-Szekely, Zsolt
    St George Hospital Fejer County, Hungary .
    Vinolas, Nuria
    Hospital Clin Barcelona, Spain .
    Sederholm, Christer
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Respiratory Medicine.
    Hartmann, Joerg T.
    Department Internal Medical II Hematol and Medical Oncol, Germany Catholic Hospital Consortium Ostwestfalen, Germany .
    Behringer, Dirk
    Clin Hematol and Oncol, Germany .
    Kazeem, Gbenga
    Eli Lilly UK, England .
    Desaiah, Durisala
    Eli Lilly Corp Centre, IN USA .
    Leschinger, Monika I.
    Lilly Deutschland GmbH, Germany .
    von Pawel, Joachim
    Asklepios Hospital Munchen Gauting, Germany .
    A randomised phase II study of pemetrexed versus pemetrexed plus erlotinib as second-line treatment for locally advanced or metastatic non-squamous non-small cell lung cancer2014In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 50, no 9, 1571-1580 p.Article in journal (Refereed)
    Abstract [en]

    Introduction: Pemetrexed and erlotinib have been approved as second-line monotherapy for locally advanced or metastatic non-small cell lung cancer (NSCLC). This multicentre, randomised, open-label, parallel phase II study assessed efficacy and safety of pemetrexed versus pemetrexed + erlotinib in patients with advanced non-squamous NSCLC. Methods: NSCLC stage III-IV patients who failed one prior platinum-based chemotherapy regimen, greater than= 1 measurable lesion by Response Evaluation Criteria in Solid Tumors, and Eastern Cooperative Oncology Group performance status less than= 2 were eligible. Patients received pemetrexed 500 mg/m(2) with vitamin B-12 and folic acid q3w alone or combined with erlotinib 150 mg daily. The primary end-point was progression-free survival (PFS). Secondary end-points were overall survival (OS), time-to-treatment failure (TTTF), response and toxicity. Results: Of 165 randomised non-squamous patients, 159 were treated (pemetrexed: 83; pemetrexed + erlotinib: 76). The median PFS (months; 95% CI) was 2.89 (1.94, 3.38) for pemetrexed versus 3.19 (2.86, 4.70) for pemetrexed + erlotinib (hazard ratio [HR] 0.63; 95% CI: (0.44, 0.90); P = 0.0047). The median OS (months; 95% CI) was 7.75 (5.29, 10.41) for pemetrexed versus 11.83 (8.18, 16.66) for pemetrexed + erlotinib (HR: 0.68; 95% CI: 0.46, 0.98; P = 0.019). The median TTTF (months: 95% CI) was 2.4 (1.74, 2.99) for pemetrexed versus 3.0 (2.23, 4.07) for pemetrexed + erlotinib (HR 0.64; 95% CI: 0.46, 0.89; P = 0.0034). One patient died in pemetrexed + erlotinib arm due to febrile neutropenia. Grades 3/4 drug-related toxicities (in greater than= 5% of patients) in pemetrexed/pemetrexed + erlotinib were febrile neutropenia (2.4%/10.5%), diarrhoea (1.2%/5.3%), rash (1.2%/9.2%); anaemia (6%/11.8%), leukopenia (9.6%/23.7%), neutropenia (9.6%/25.0%), and thrombocytopenia (4.8%/14.5%). Conclusions: Pemetrexed + erlotinib treatment significantly improved PFS, OS and TTTF in 2nd line non-squamous NSCLC and was associated with an increase in grade 3/4 toxicities compared with pemetrexed alone.

  • 45.
    Friström, Björn
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Ophthalmology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL/MH.
    Uusitalo, Hannu
    University of Tampere.
    A randomized, 36-month, post-marketing efficacy and tolerability study in Sweden and Finland of latanoprost versus non-prostaglandin therapy in patients with glaucoma or ocular hypertension2010In: ACTA OPHTHALMOLOGICA, ISSN 1755-375X, Vol. 88, no 1, 37-43 p.Article in journal (Refereed)
    Abstract [en]

    Purpose: To compare the effect of time on therapy, efficacy, tolerability and resource utilization of latanoprost or non-prostaglandin analogues (non-PGs) in patients who required a change in intraocular pressure (IOP)-lowering monotherapy. Methods: This open-label, multicentre study (Sweden, 19 sites; Finland, seven sites) included adults with glaucoma or ocular hypertension with mean diurnal IOP andgt;= 21 mmHg on ocular hypotensive monotherapy. Patients were randomized to latanoprost monotherapy or non-PG therapy (commercially available therapy other than a PG) and followed for 36 months. End-points included: time to treatment failure (baseline to visit with a change in/addition to treatment); diurnal IOP (mean of 08.00, 12.00 and 16:00 hr measurements) at months 6, 12, 24 and 36; tolerability; and resource utilization, where analyses used Swedish and Finnish 2006 unit costs. Results: Three hundred and twenty-six patients received andgt;= 1 dose of latanoprost (n = 162) or non-PGs (n = 164). Median time to treatment failure was longer for latanoprost (36 months) than for non-PGs (12 months; p andlt; 0.001); 51% and 24% of patients remained on randomized therapy after 36 months, respectively (p andlt; 0.001). Decreases in mean diurnal IOP from baseline were significantly greater for latanoprost than for non-PGs at months 6 and 12 (p andlt; 0.01). No serious adverse events were judged to be treatment-related. Mean total 36-month direct costs were similar in patients initiated with latanoprost and non-PGs. Conclusion: Patients who failed previous monotherapy remained on therapy longer when switched to latanoprost. Latanoprosts IOP-reducing effect and tolerability were sustained over the long term. Resource utilization and costs were generally similar in those initiating latanoprost or non-PG therapy.

  • 46.
    Myrelid, Pär
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping. Linköping University, Faculty of Medicine and Health Sciences.
    Oresland, Tom
    University of Oslo, Norway; Akershus University Hospital, Norway.
    A reappraisal of the ileo-rectal anastomosis in ulcerative colitis2015In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 9, no 6, 433-438 p.Article, review/survey (Refereed)
    Abstract [en]

    Colectomy is still frequently required in the care of ulcerative colitis. The most common indications are either non-responding colitis in the emergency setting, chronic active disease, steroid-dependent disease or neoplastic change like dysplasia or cancer. The use of the ileal pouch anal anastomosis has internationally been the gold standard, substituting the rectum with a pouch. Recently the use of the ileorectal anastomosis has increased in frequency as reconstructive method after subtotal colectomy. Data from centres using ileorectal anastomosis have shown the method to be safe, with functionality and risk of failure comparable to the ileal pouch anal anastomosis. The methods have different advantages as well as disadvantages, depending on a number of patient factors and where in life the patient is at time of reconstruction. The ileorectal anastomosis could, together with the Kock continent ileostomy, in selected cases be a complement to the ileal pouch anal anastomosis in ulcerative colitis and should be discussed with the patient before deciding on reconstructive method.

  • 47.
    Zhang, Jingcheng
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, The Institute of Technology.
    A Remote Monitoring and Control System for Cultural Heritage Buildings Utilizing Wireless Sensor Networks2014Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    This dissertation presents the study of a wireless remote monitoring and control system utilized for cultural heritage preservation purpose. The system uses wireless sensor networks to remotely monitor and control the indoor climate, i.e., temperature and relative humidity of the cultural buildings.

    The system mainly consists of three parts, i.e., the wireless sensor network part, the gateway part and the web service part. Wireless sensor networks are deployed in different cultural buildings. The ZigBee protocol is utilized for the wireless sensor network communication. Sensor nodes report the indoor climate periodically. By connecting with radiators and/or dehumidifiers, the wireless control nodes can control the indoor climate according to the remote configuration. A gateway maintains the communication between a wireless sensor network and the web service. In monitoring function, the gateway forwards sensor messages from the wireless sensor network to the web service. In control function, the gateway synchronizes the climate settings from the web service to the wireless sensor network. The gateway also sends control commands to the wireless control nodes in the wireless sensor network. The web service provides a web-based user interface for the system.

    Different from ordinary cable-connected sensor networks, a wireless sensor network that works for cultural heritage preservation should be a system with a large number of sensor nodes covering a large area in a building, high reliability in message transmission, low power consumption and low cost. In this study, the performance of the ZigBee wireless network is improved to meet such requirements base on the investigation of the ZigBee protocol limitation. Firstly, a method for enhancing the wireless sensor network communication reliability is developed. The reactive routing protocol defined by the ZigBee standard is improved so that the wireless nodes automatically detect and repair network communication problems. This method minimizes the message lost within the wireless sensor network by always reserving a route from the source node to the destination node. Secondly, a generic low power working method is developed for sensor devices. This method defines the general sensor module behavior which includes sensor data collecting, sensor message forwardingand wireless network rejoining upon communication failure. It allows sensor devices to maintain high message reliability with low power consumption. Especially, these methods are developed as a complementary infrastructure of the ZigBee wireless sensor network in order to increase the transmission reliability with low power consumption. Finally, methods and algorithms are developed to make it possible to power the ZigBee message relays (i.e., routers) with small batteries. In this system, the whole ZigBee network is synchronized. Wireless communications within the ZigBee network are scheduled so that every wireless transmission is collision-free. During the period when no communication is scheduled, the router can go into low power mode. This design improvement removes the original requirement of using mains power for ZigBee message relays. A truly battery-driven and low power consumption wireless sensor network is developed for monitoring cultural heritage buildings without (or with limited) mains power.

    The remote control function is developed to mainly prevent biological degradation by controlling indoor climate, i.e., temperature and relative humidity. After studying the requirements for heritage preservation, a high flexibility, high reliability and low cost wireless indoor climate control system is developed. Different control algorithms are implemented to achieve different control results.

    Till today, the remote monitoring and control system presented in this dissertation has been installed in 31 cultural heritage buildings both in Sweden and Norway.

    List of papers
    1. Remote Sensing System for Cultural Buildings Utilizing ZigBee Technology
    Open this publication in new window or tab >>Remote Sensing System for Cultural Buildings Utilizing ZigBee Technology
    2010 (English)Conference paper, Published paper (Refereed)
    Abstract [en]

    A wireless remote sensing system using the ZigBee standard ispresented in this paper. This system is a wireless solution formonitoring purpose in cultural buildings in order to protectcultural heritage. The concept of this system utilizes ZigBeenetworks to carry and transmit data collected by sensors andstore them into both local and remote databases. Thus, users canmonitor the measured data locally or remotely. Especially, thepower consumption is optimized to extend the lifetime of thebattery-driven devices. Moreover, since the system has amodular architecture, it is easy to add extra services into thissystem.

    Keyword
    Modular system, power consumption, wireless sensor network, ZigBee
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-61295 (URN)
    Conference
    8th. International Conference on Computing, Communications and Control Technologies (CCCT 2010), April 6 - 9, Orlando, FL, USA
    Projects
    CultureBee
    Available from: 2010-11-10 Created: 2010-11-10 Last updated: 2013-12-16Bibliographically approved
    2. Design of the Remote Climate Control System for Cultural Buildings Utilizing ZigBee Technology
    Open this publication in new window or tab >>Design of the Remote Climate Control System for Cultural Buildings Utilizing ZigBee Technology
    2010 (English)In: Sensors & Transducers Journal, ISSN 1726-5479, Vol. 118, no 7, 13-27 p.Article in journal (Refereed) Published
    Abstract [en]

    A wireless solution of remote climate control for cultural buildings is presented in this paper. The system allows users to use web service to control climate in different cultural buildings, like churches. The wireless sensor networks deployed in churches receive the control commands and manage the indoor climate. The whole system is modularly designed, which makes possible an easy service extension, system reconfiguration and modification. This paper includes the system overview and the software design of each part within the system.

    Keyword
    ZigBee, Wireless sensor network, Remote control, Modular system design
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-61293 (URN)
    Projects
    CultureBee
    Available from: 2010-11-10 Created: 2010-11-10 Last updated: 2013-12-16Bibliographically approved
    3. Reliability and Latency Enhancements in a ZigBee Remote Sensing System
    Open this publication in new window or tab >>Reliability and Latency Enhancements in a ZigBee Remote Sensing System
    2010 (English)Conference paper, Published paper (Other academic)
    Abstract [en]

    Methods to improve the reliability and optimize the system latency of our own-developed ZigBee remote sensing system are introduced in this paper. The concept of this system utilizes the ZigBee network to transmit sensor information and process them at both local and remote databases. The enhancement has been done in different parts in this system. In the ZigBee network part, the network topology is configured and controlled. The latency for message transmitting is also optimized. In the data processing part, the network status check function and data buffer function are introduced to improve the system reliability. Additionally, the system latency is measured to compare with the Ad-hoc On Demand Distance Vector algorithm used in the ZigBee standard.

    Keyword
    System reliability, system latency, ZigBee network topology configuration, data buffering
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-61294 (URN)10.1109/SENSORCOMM.2010.38 (DOI)978-1-4244-7538-4 (ISBN)
    Conference
    The Fourth International Conference on Sensor Technologies and Applications (SENSORCOMM 2010), July 18 - 25, Venice/Mestre, Italy
    Projects
    CultureBee
    Available from: 2010-11-10 Created: 2010-11-10 Last updated: 2014-09-25Bibliographically approved
    4. A Fully Wireless Monitoring and Control System for Protecting Cultural Heritage
    Open this publication in new window or tab >>A Fully Wireless Monitoring and Control System for Protecting Cultural Heritage
    2011 (English)In: Proceedings of 2011 20th IEEE International Workshops on Enabling Technologies: Infrastructure for Collaborative Enterprises WETICE 2011, IEEE , 2011, 250-255 p.Conference paper, Published paper (Refereed)
    Abstract [en]

    This paper presents a component based wireless monitoring and control system. The system is introduced from both the system architecture and function point of view. The paper begins with the introduction of the component design and the communication interaction between them. The system is composed by three components, the wireless sensor network, the local server and the main server. Wireless sensor networks are deployed in different locations for remote monitoring and control purpose. The monitoring results and control commands are synchronized between the main server and wireless sensor networks via local servers. The test results of the battery life time calculation and remote monitoring field test results are presented in the end of the paper.

    Place, publisher, year, edition, pages
    IEEE, 2011
    Series
    IEEE International Workshop on Enabling Technologies, ISSN 1524-4547
    National Category
    Engineering and Technology
    Identifiers
    urn:nbn:se:liu:diva-71523 (URN)10.1109/WETICE.2011.43 (DOI)978-1-4577-0134-4 (ISBN)
    Conference
    20th IEEE International Workshops on Enabling Technologies: Infrastructure for Collaborative Enterprises (WETICE), 27-29 June, Paris, France
    Available from: 2011-10-20 Created: 2011-10-20 Last updated: 2013-12-16Bibliographically approved
    5. A Communication Reliability Enhancement Framework for Wireless Sensor Network Using the ZigBee Protocol
    Open this publication in new window or tab >>A Communication Reliability Enhancement Framework for Wireless Sensor Network Using the ZigBee Protocol
    2012 (English)In: Sensors & Transducers Journal, ISSN 1726-5479, Vol. 135, no 12, 42-56 p.Article in journal (Refereed) Published
    Abstract [en]

    This paper presents the methods for the ZigBee network reliability enhancement and the battery life time optimization. The paper begins with the introduction of the common communication problems due to the broken links between sensor module and message relay, or between different relays. Extra message hand shake mechanisms are added to solve different problem mentioned at the beginning. Finally, a general purpose reliability enhancement component is developed as a state machine which can be work together with ZigBee protocol to enhance ZigBee network communication reliability. Moreover, the battery life time of the sensor module during link broken is considerably increased after the enhancement.

    Keyword
    Communication reliability enhancement, ZigBee, Reusable, Reconfigurable
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:liu:diva-79896 (URN)
    Note

    On the day of the defence date the status of this article was "Manuscript" and the title was "A Communication Reliability Enhancement Framework for the ZigBee WirelessSensor Network".

    Available from: 2012-08-15 Created: 2012-08-15 Last updated: 2013-12-16Bibliographically approved
    6. A Web-based Remote Indoor Climate Control System Based on Wireless Sensor Network
    Open this publication in new window or tab >>A Web-based Remote Indoor Climate Control System Based on Wireless Sensor Network
    Show others...
    2013 (English)In: International Journal of Sensors and Sensor Networks, Vol. 1, no 3, 32-40 p.Article in journal (Refereed) Published
    Abstract [en]

    This paper presents the design and implementation of a web-based wireless indoor climate control system. The user interface of the system is implemented as a web service. People can login to the website and remotely control the indoor climate of different locations. A wireless sensor network is deployed in each location to execute control commands. A gateway is implemented to synchronize the information between the wireless sensor network and the web service. The gateway software also includes scheduling function and different control algorithms to improve the control result. Additionally, the system security and availability are highly considered in this system. The gateway software implements a warning function which sends warning messages when emergency happens. Finally, the whole wireless control system architecture is modularly designed. It is easy to add different control applications or different control algorithms into the system.

    Place, publisher, year, edition, pages
    Science Publishing Group, 2013
    Keyword
    Remote Control, Indoor Climate, Wireless Sensor Network
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:liu:diva-102588 (URN)10.11648/j.ijssn.20130103.12 (DOI)
    Available from: 2013-12-16 Created: 2013-12-16 Last updated: 2014-01-17Bibliographically approved
    7. Design and Implementation of a Truly Battery-Driven ZigBee Wireless Sensor Network
    Open this publication in new window or tab >>Design and Implementation of a Truly Battery-Driven ZigBee Wireless Sensor Network
    2013 (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    As defined by the ZigBee standard, a router should be mains-powered in order to maintain the mesh feature of the ZigBee network. This study presents a method which allows the ZigBee router goes into sleep mode periodically and keeps the same mesh feature during the ZigBee communications. In this study, the standard ZigBee communication is separated into two synchronized clusters. The first cluster includes the communication between end devices and the associated router. The sensor message report time of different end devices are scheduled by the router in different collision-free time slots within a predefined time interval. The second cluster includes the mesh communication between routers and the concentrator. All routers are synchronized so that they wake up at the same time to maintain the mesh feature. In order to maximize the router battery lifetime, algorithms are developed so that the concentrator communicates with routers according to the network routing records. Additionally, in order to recover the broken communication, special logics are implemented in routers and end device so that they can rejoin the wireless sensor network with low power consumption. Finally, a battery lifetime model is presented which can be utilized to calculate battery lifetime of the ZigBee router under different network configurations.

    Keyword
    Low Power, ZigBee Router, Wireless Sensor Network, High Availability
    National Category
    Electrical Engineering, Electronic Engineering, Information Engineering
    Identifiers
    urn:nbn:se:liu:diva-102590 (URN)
    Available from: 2013-12-16 Created: 2013-12-16 Last updated: 2013-12-16Bibliographically approved
  • 48.
    Sköld, Carl Magnus
    et al.
    Department of Medicine Solna, Karolinska Institutet, Lung-Allergy Clinic, Karolinska University Hospital Solna, Stockholm, Sweden.
    Janson, Christer
    Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
    Klackenberg Elf, Åsa
    InterMune Nordics AB, Stockholm, Sweden; Roche AB, Stockholm, Sweden.
    Fiaschi, Marie
    Roche AB, Stockholm, Sweden.
    Wiklund, Kerstin
    PCG Clinical Services, Uppsala, Sweden.
    Persson, Hans Lennart
    Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Respiratory Medicine.
    A retrospective chart review of pirfenidone-treated patients in Sweden: the REPRIS study2016In: European Clinical Respiratory Journal, E-ISSN 2001-8525, Vol. 3, no 1, 32035Article in journal (Refereed)
    Abstract [en]

    Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease that usually results in respiratory failure and death. Pirfenidone was approved as the first licensed therapy for IPF in Europe based on phase III trials where patients with a forced vital capacity (FVC) greater than50% of predicted were included. The aim of this study was to characterise patients treated with pirfenidone in Swedish clinical practice and to describe the adherence to the reimbursement restriction since reimbursement was only applied for patients with FVC below 80% of predicted.less thanbr /greater thanMethods: This was a retrospective, observational chart review of IPF patients treated with pirfenidone from three Swedish university clinics. Patients initiated on treatment during the period 28 June 2012 to 20 November 2014 were included. Data on patient characteristics, basis of diagnosis, treatment duration, quality of life, and adverse drug reactions (ADRs) were collected from medical charts.less thanbr /greater thanResults: Forty-four patients were screened and 33 were included in the study. The mean treatment duration from start of pirfenidone until discontinuation or end of study was 38 weeks. At the initiation of pirfenidone treatment, FVC was 62.7% (12.1) [mean (SD)], diffusion capacity (DLco) was 45.1% (13.8) of predicted, and the ratio of forced expiratory volume on 1 sec (FEV1) to FVC was 0.78 (0.1). The percentage of patients with an FVC between 50 and 80% was 87%. Ten of the patients had ADRs including gastrointestinal and skin-related events, cough and signs of impaired hepatic function, but this led to treatment discontinuation in only two patients.less thanbr /greater thanConclusion: Data from this chart review showed that adherence to the Swedish reimbursement restriction was followed in the majority of patients during the study period. At the start of pirfenidone treatment, lung function, measured as FVC, was lower in the present cohort of Swedish IPF patients compared with other registry and real-life data. About a third of the patients had ADRs, but discontinuation of the treatment because of ADRs was relatively uncommon.

  • 49.
    Johansson, Maria
    et al.
    Linköping University, Department of Management and Engineering, Energy Systems. Linköping University, Faculty of Science & Engineering.
    Thollander, Patrik
    Linköping University, Department of Management and Engineering, Energy Systems. Linköping University, Faculty of Science & Engineering.
    A review of barriers to and driving forces for improved energy efficiency in Swedish industry: Recommendations for successful in-house energy management2018In: Renewable & sustainable energy reviews, ISSN 1364-0321, E-ISSN 1879-0690, Vol. 82, no Part 1, 618-628 p.Article in journal (Refereed)
    Abstract [en]

    From an environmental point of view, reduced use of energy remains a cornerstone in global greenhouse gas mitigation. However, without full internalization of external costs, greenhouse gas mitigation as such may not be highly prioritized among business leaders. Rather, it is the magnitude of production costs and ultimately the size of market revenue that articulates success or failure for business leaders. Nevertheless, reduced energy use or improved energy efficiency can have a vast impact on profitability even for companies with low energy costs, as the reduced energy costs directly lead to increased profits. In this paper, a review of ten years of empirical research in the field of industrial energy management in Swedish industry is presented. Based on the review, the paper proposes success factors for efficient energy management, factors which could help guide individual energy managers as well as policy makers in order to close the energy efficiency and management gaps. The paper also presents an overview of important industrial energy management tools, which would facilitate in-house energy management in industry.

    The full text will be freely available from 2019-10-06 12:45
  • 50.
    Thollander, Patrik
    et al.
    Linköping University, Department of Management and Engineering, Energy Systems. Linköping University, Faculty of Science & Engineering.
    Kimura, Osamu
    Central Research Institute Elect Power Ind, Japan.
    Wakabayashi, Masayo
    Central Research Institute Elect Power Ind, Japan.
    Rohdin, Patrik
    Linköping University, Department of Management and Engineering, Energy Systems. Linköping University, Faculty of Science & Engineering.
    A review of industrial energy and climate policies in Japan and Sweden with emphasis towards SMEs2015In: Renewable & sustainable energy reviews, ISSN 1364-0321, E-ISSN 1879-0690, Vol. 50, 504-512 p.Article, review/survey (Refereed)
    Abstract [en]

    The threat of increased global warming resulting from the use of fossil fuels stresses decision-makers to formulate and adopt policies towards different sectors of the economy. In light of the great earthquake in Japan 2011, energy efficiency also plays an important role in meeting the challenge of power supply shortage. Energy policies towards industry are of particular importance as a major part of the energy in the economy is used in industrial production. The number of papers investigating and presenting experience from energy end-use policies are scarce. Furthermore, for those present, they often only include a very brief analysis. From a public point of view, evaluations of energy programs are of major importance to measure the performance of the programs. From an energy policy designer point of view, it is of major importance to not only see the cost-effectiveness of the policy but also to understand the fundamental mechanisms for the success or failure of an industrial energy program, in order to learn how to improve future programs. The aim of this paper is to present a review of energy end-use policy instrument in Japan and Sweden towards the industrial sector from 1990 to 2014, with special emphasis on industrial SMEs. From the results presented some general-conclusions can be made, (1) results show that the cost-effectiveness differs substantially between the evaluated programs, and (2) that from a governmental point of view, subsidies towards energy audit programs seem like the most cost-effective policy. In addition to this (3) the results from the review also stress the importance of a clear strategy for every energy program on how the program is going to be evaluated, ex-ante or ex-post, and how the performance of the program is to be measured. This structure should be included from the start of the program. (C) 2015 Elsevier Ltd. All rights reserved.

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