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  • 1.
    Hallert, Eva
    et al.
    Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Rehabilitation Center. Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics.
    Husberg, Magnus
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Skogh, Thomas
    Linköping University, Department of Clinical and Experimental Medicine, Rheumatology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Department of Rheumatology.
    28-joint count disease activity score at 3 months after diagnosis of early rheumatoid arthritis is strongly associated with direct and indirect costs over the following 4 years: the Swedish TIRA project2011In: Rheumatology, ISSN 1462-0324, E-ISSN 1462-0332, Vol. 50, no 7, 1259-1267 p.Article in journal (Refereed)
    Abstract [en]

    Methods. Three-hundred and twenty patients with early (1 year) RA were assessed at regular intervals. Clinical and laboratory data were collected and patients reported health-care utilization and number of days lost from work. At 3-month follow-up, patients were divided into two groups according to disease activity, using DAS-28 with a cut-off level at 3.2. Direct and indirect costs and EuroQol-5D over the following 4 years were compared between the groups. Multivariate regression models were used to control for possible covariates. Results. Three months after diagnosis, a DAS-28 level of epsilon 3.2 was associated with high direct and indirect costs over the following 4 years. Patients with DAS-28 epsilon 3.2 at 3-month follow-up had more visits to physician, physiotherapist, occupational therapist and nurse, higher drug costs, more days in hospital and more extensive surgery compared with patients with 3-month DAS-28 less than 3.2. Number of days lost from work due to sick leave and permanent work disability was also higher in this group. The effect of disease activity on health-related quality of life was highly significant. In regression models, DAS-28 at 3-month follow-up was significantly associated with costs over the following years. Conclusions. Three months after diagnosis, DAS-28 is an important prognostic marker regarding health-care utilization and costs. Achieving remission or low disease activity 3 months after diagnosis is likely to decrease morbidity, increase quality of life and save costs for the patient and for society over the following years.

  • 2.
    Yu, Zhengquan
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Pathology. Linköping University, Department of Neuroscience and Locomotion, Neurosurgery. Linköping University, Faculty of Health Sciences.
    Li, Wei
    Linköping University, Department of Neuroscience and Locomotion, Pathology. Linköping University, Faculty of Health Sciences.
    Brunk, Ulf
    Linköping University, Department of Neuroscience and Locomotion, Pathology. Linköping University, Faculty of Health Sciences.
    3-Aminopropanal is a lysosomotropic aldehyde that causes oxidative stress and apoptosis by rupturing lysosomes2003In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 111, no 6, 643-652 p.Article in journal (Refereed)
    Abstract [en]

    During cerebral ischemia and following trauma, potent cytotoxic polyamine-derived aminoaldehydes form, diffuse, and damage adjacent tissues not directly subjected to the initial insult. One such aldehyde is 3-aminopropanal (3-AP). The mechanisms by which such a small aldehydic compound is excessively cytotoxic have been unclear until recently when we showed that 3-AP, having the structure of a weak lysosomotropic base, concentrates within the acidic vacuolar compartment and causes lysosomal rupture that, in turn, induces caspase activation and apoptotic cell death. Here, using cultured J774 cells and 3-AP as a way to selectively burst lysosomes, we show that moderate lysosomal rupture induces a transient wave of oxidative stress. The start of this oxidative stress period is concomitant with a short period of enhanced mitochondrial membrane potential that later fades and is replaced by a decreased potential before the oxidative stress diminishes. The result of the study suggests that oxidative stress, which has often been described during apoptosis induced by agonists other than oxidative stress per se, may be a consequence of lysosomal rupture with direct and/or indirect effects on mitochondrial respiration and electron transport causing a period of passing enhanced formation of reactive oxygen species.

  • 3. Imura, M
    et al.
    Kuroda, T
    Oshiro, O
    Chihara, K
    Brandberg, Joakim
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    Ask, Per
    Linköping University, The Institute of Technology. Linköping University, Department of Biomedical Engineering, Physiological Measurements.
    3-D flow visualization for construction of the model of the blood flow in the heart2000In: Japanese Journal of Applied Physics, ISSN 0021-4922, Vol. 39, no 5 B, 3246-3251 p.Article in journal (Refereed)
    Abstract [en]

    The authors have been developing a model of blood flow in the heart. The flow model of the heart enables us to estimate the entire blood flow of the heart from a couple of 2-D color Doppler images. Therefore, the load on patients is expected to be reduced. To develop the model of the heart, precise observation and an understanding of the blood flow are indispensable, because the flow is strongly related to the diagnosis of heart diseases. The visualization method must have the following features: (1) 3-D (2) objectivity (3) interactivity and (4) multi-aspect. The authors have developed visualization methods to meet the above-mentioned requirements and evaluated the proposed methods with the in-vitro flow data set. The results clearly reveal that the proposed system enables the researchers of the modeling group to obtain the state of entire flow, such as the occurrence of turbulence.

  • 4.
    Lavrykov, Sergiy
    et al.
    State University of New York, Dept of Paper and Bioprocess Engineering.
    Lindström, Stefan B
    Linköping University, Department of Management and Engineering, Mechanics. Linköping University, The Institute of Technology.
    Singh, K. M.
    International Paper Co..
    Ramarao, Bandaru
    State University of New York, Dept of Paper and Bioprocess Engineering.
    3D network simulations of paper structurewith fines and fillers2012In: Nordic Pulp and Paper Research Journal, ISSN 0283-2631, Vol. 27, no 2, 256-263 p.Article in journal (Refereed)
    Abstract [en]

    The structure of paper influences its properties and simulations of it are necessary to understand the impact of fiber and papermaking conditions on the sheet properties. We show a method to develop a representative structure of paper by merging different simulation techniques for the forming section and the pressing operation. The simulation follows the bending and drape of fibers over one another in the final structure and allows estimation of sheet properties without recourse to arbitrary bending rules or experimental measurements of density and/or RBA. Fibers are first modeled as jointed beams following the fluid mechanics in the forming section. The sheet structure obtained from this is representative of the wet sheet from the couch. The pressing simulation discretizes fibers into a number of solid elements around the lumen. Bonding between fibers is simulated using spring elements. The resulting fiber network was analyzed to determine its elastic modulus and deformation under small strains. The influence of fiber dimensions, namely fiber lengths, widths and thicknesses as well as bond stiffnesses on the elasticity of the network are studied. A brief account of inclusion of fines, represented by individual cubical elements is also shown.

  • 5.
    Markström, Johannes
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    3D Position Estimation of a Person of Interest in Multiple Video Sequences: People Detection2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In most cases today when a specific person's whereabouts is monitored through video surveillance it is done manually and his or her location when not seen is based on assumptions on how fast he or she can move. Since humans are good at recognizing people this can be done accurately, given good video data, but the time needed to go through all data is extensive and therefore expensive. Because of the rapid technical development computers are getting cheaper to use and therefore more interesting to use for tedious work.

    This thesis is a part of a larger project that aims to see to what extent it is possible to estimate a person of interest's time dependent 3D position, when seen in surveillance videos. The surveillance videos are recorded with non overlapping monocular cameras. Furthermore the project aims to see if the person of interest's movement, when position data is unavailable, could be predicted. The outcome of the project is a software capable of following a person of interest's movement with an error estimate visualized as an area indicating where the person of interest might be at a specific time.

    This thesis main focus is to implement and evaluate a people detector meant to be used in the project, reduce noise in position measurement, predict the position when the person of interest's location is unknown, and to evaluate the complete project.

    The project combines known methods in computer vision and signal processing and the outcome is a software that can be used on a normal PC running on a Windows operating system. The software implemented in the thesis use a Hough transform based people detector and a Kalman filter for one step ahead prediction. The detector is evaluated with known methods such as Miss-rate vs. False Positives per Window or Image (FPPW and FPPI respectively) and Recall vs. 1-Precision.

    The results indicate that it is possible to estimate a person of interest's 3D position with single monocular cameras. It is also possible to follow the movement, to some extent, were position data are unavailable. However the software needs more work in order to be robust enough to handle the diversity that may appear in different environments and to handle large scale sensor networks.

  • 6.
    Hultman, Martin
    et al.
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    Fredriksson, Ingemar
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Perimed AB, Järfälla-Stockholm, Sweden.
    Larsson, Marcus
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Integrated Circuits and Systems. Linköping University, Faculty of Science & Engineering.
    Strömberg, Tomas
    Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.
    A 15.6 frames per second 1 megapixel Multiple Exposure Laser Speckle Contrast Imaging setup2017In: Journal of Biophotonics, ISSN 1864-063X, E-ISSN 1864-0648Article in journal (Refereed)
    Abstract [en]

    A multiple exposure laser speckle contrast imaging (MELSCI) setup for visualizing blood perfusion was developed using a field programmable gate array (FPGA), connected to a 1000 frames per second (fps) 1-megapixel camera sensor. Multiple exposure time images at 1, 2, 4, 8, 16, 32 and 64 milliseconds were calculated by cumulative summation of 64 consecutive snapshot images. The local contrast was calculated for all exposure times using regions of 4 × 4 pixels. Averaging of multiple contrast images from the 64-millisecond acquisition was done to improve the signal-to-noise ratio. The results show that with an effective implementation of the algorithm on an FPGA, contrast images at all exposure times can be calculated in only 28 milliseconds. The algorithm was applied to data recorded during a 5 minutes finger occlusion. Expected contrast changes were found during occlusion and the following hyperemia in the occluded finger, while unprovoked fingers showed constant contrast during the experiment. The developed setup is capable of massive data processing on an FPGA that enables processing of MELSCI data in 15.6 fps (1000/64 milliseconds). It also leads to improved frame rates, enhanced image quality and enables the calculation of improved microcirculatory perfusion estimates compared to single exposure time systems.

    The full text will be freely available from 2018-08-07 12:43
  • 7.
    Aamir, Syed Ahmed
    et al.
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    Wikner, J Jacob
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    A 500-MHz low-voltage programmable gain amplifier for HD video in 65-nm CMOS2010In: Proceedings of 28th IEEE Norchip Conference., NORCHIP'10, Tampere: www.ieee.org , 2010, 1-4 p.Conference paper (Refereed)
    Abstract [en]

    This work describes the implementation of a 1.2-V programmable gain amplifier (PGA) for high-definition (HD) video digitizers in a 65-nm digital CMOS process. The “pseudo” switched-capacitor (SC) PGA architecture buffers the video signal, without switching, during the active video. The SC circuitry is used for setup of DC operating point during horizontal and vertical blanking periods. Additionally, it compensates for the `sync-tip' of analog video signals to an equal blanking level for increased dynamic range to the digitizer following the PGA. The operational transconductance amplifier (OTA) employed as main amplifier in the PGA is a pseudo-differential, positive-feedback input stage architecture with a common-mode feedforward (CMFF) technique. The common-mode feedback (CMFB) is provided once two OTAs are cascaded. Schematic-level simulation results show that the OTA maintains a -3-dB bandwidth of 550 MHz, while keeping the distortion HD3 at -60 dB for a 30-MHz, 850 mVpp high definition video signal. The 88 dB DC gain is distributed among four OTA stages and the overall, combined PGA achieves a signal-to-noise ratio of 63 dB. Due to only two stacked transistors, it achieves high output swing of ±0.85 V, 1240 V/μs slew rate while consuming 10.4 mW power.

  • 8. Amin, AI
    et al.
    Hallböök, Olof
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Biomedicine and Surgery, Surgery. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Surgery in Östergötland.
    Lee, AJ
    Sexton, R
    Moran, BJ
    Heald, RJ
    A 5-cm colonic J pouch colo-anal reconstruction following anterior resection for low rectal cancer results in acceptable evacuation and continence in the long term2003In: Colorectal Disease, ISSN 1462-8910, Vol. 5, no 1, 33-37 p.Article in journal (Refereed)
    Abstract [en]

    Background. Optimal treatment for low rectal cancer is total mesorectal excision, with most patients suitable for low colo-rectal or colo-anal anastomosis. A colon pouch has early functional benefits, although long-term function, especially evacuation, might mitigate against its routine use. The aim of this study was to assess evacuation and continence in patients with a colon pouch, and to examine the impact of possible risk factors. Methods. In 1998, all 102 surviving patients with a colon pouch, whose stoma had been closed for more than one year, were sent a postal questionnaire. A composite incontinence score was calculated from questions on urgency, use of a pad, incontinence of gas, liquid or faeces, and a composite evacuation score from questions on medication taken to evacuate, straining, the need and number of times returned to evacuate. Results. The response rate was 90% (50 M, 42 F), with a median age of 68 years (IQR 60-78) and median follow-up of 2.6 years (IQR 1.7-3.9). The anastomosis was 3 cm or less from the anus in 45/92 (49%), and incontinence scores were worse in this group (P = 0.001). There were significantly higher incontinence scores in females (P = 0.014). Age, preoperative radiotherapy, part of colon used for anastomosis, post-operative leak and length of follow-up had no demonstrable effect on either score. Conclusion. Gender and anastomotic height were the only variables which influenced incontinence. Ninety percent of patients reported that their bowel function did not affect their overall wellbeing, and none would have preferred to have a stoma.

  • 9.
    Engquist, Markus
    et al.
    Ryhov Hospital, Sweden.
    Löfgren, Håkan
    Ryhov Hospital, Sweden.
    Öberg, Birgitta
    Linköping University, Department of Medical and Health Sciences, Division of Physiotherapy. Linköping University, Faculty of Medicine and Health Sciences.
    Holtz, Anders
    University of Uppsala Hospital, Sweden.
    Peolsson, Anneli
    Linköping University, Department of Medical and Health Sciences, Division of Physiotherapy. Linköping University, Faculty of Medicine and Health Sciences.
    Söderlund, Anne
    Mälardalen University, Sweden.
    Vavruch, Ludek
    Ryhov Hospital, Sweden.
    Lind, Bengt
    University of Gothenburg, Sweden; Spine Centre Göteborg, Sweden.
    A 5-to 8-year randomized study on the treatment of cervical radiculopathy: anterior cervical decompression and fusion plus physiotherapy versus physiotherapy alone2017In: JOURNAL OF NEUROSURGERY-SPINE, ISSN 1547-5654, Vol. 26, no 1, 19-27 p.Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE The aim of this study was to evaluate the 5- to 8-year outcome of anterior cervical decompression and fusion (ACDF) combined with a structured physiotherapy program as compared with that following the same physiotherapy program alone in patients with cervical radiculopathy. No previous prospective randomized studies with a follow-up of more than 2 years have compared outcomes of surgical versus nonsurgical intervention for cervical radiculopathy. METHODS Fifty-nine patients were randomized to ACDF surgery with postoperative physiotherapy (30 patients) or to structured physiotherapy alone (29 patients). The physiotherapy program included general and specific exercises as well as pain coping strategies. Outcome measures included neck disability (Neck Disability Index [NDI]), neck and arm pain intensity (visual analog scale [VAS]), health state (EQ-5D questionnaire), and a patient global assessment. Patients were followed up for 5-8 years. RESULTS After 5-8 years, the NDI was reduced by a mean score% of 21 (95% CI 14-28) in the surgical group and 11% (95% CI 4%-18%) in the nonsurgical group (p = 0.03). Neck pain was reduced by a mean score of 39 mm (95% CI 26-53 mm) compared with 19 mm (95% CI 7-30 mm; p = 0.01), and arm pain was reduced by a mean score of 33 mm (95% CI 18-49 mm) compared with 19 mm (95% CI 7-32 mm; p = 0.1), respectively. The EQ-5D had a mean respective increase of 0.29 (95% CI 0.13-0.45) compared with 0.14 (95% CI 0.01-0.27; p = 0.12). Ninety-three percent of patients in the surgical group rated their symptoms as "better" or "much better" compared with 62% in the nonsurgical group (p = 0.005). Both treatment groups experienced significant improvement over baseline for all outcome measures. CONCLUSIONS In this prospective randomized study of 5- to 8-year outcomes of surgical versus nonsurgical treatment in patients with cervical radiculopathy, ACDF combined with physiotherapy reduced neck disability and neck pain more effectively than physiotherapy alone. Self-rating by patients as regards treatment outcome was also superior in the surgery group. No significant differences were seen between the 2 patient groups as regards arm pain and health outcome.

  • 10. Dieperink, Willem
    et al.
    van der Horst, Iwan C C
    Nannenberg-Koops, Jaqueline W
    Brouwer, Henk W
    Jaarsma, T
    Nieuwland, Wybe
    Zijlstra, Felix
    Nijsten, Maarten W N
    A 64-year old man who sustained many episodes of acute cardiogenic pulmonary edema successfully treated with Boussignac continuous positive airway pressure: a case report.2007In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 119, no 2, 268-70 p.Article in journal (Refereed)
    Abstract [en]

    Continuous positive airway pressure (CPAP) is standard treatment for patients with acute cardiogenic pulmonary edema. We describe a patient who had 21 episodes of acute cardiogenic pulmonary edema due to very poor patient compliance. This 64-year old man had end-stage congestive heart failure based on systolic left ventricular dysfunction following two myocardial infarctions. In addition to routine medical treatment 15 episodes of pulmonary edema were successfully treated with Boussignac continuous positive airway pressure (BCPAP). The BCPAP system is a simple, disposable, FDA-approved device that delivers positive pressure without a ventilator. This extraordinary case underscores the utility of the BCPAP system to avoid repeated intubation and mechanical ventilation in patients with cardiogenic pulmonary edema.

  • 11.
    Thornberg, Robert
    Linköping University, Department of Behavioural Sciences and Learning, Teaching and Learning in School, Teacher Education and other Educational Settings. Linköping University, Faculty of Educational Sciences.
    A Categorisation of School Rules2008In: Educational Studies, ISSN 0013-1946, E-ISSN 1532-6993, Vol. 34, no 1, 25-33 p.Article in journal (Refereed)
    Abstract [en]

    The aim of this paper is to investigate and describe the content in school rules by developing a category system of school rules, and thus making the logic behind different types of rules in school explicit. Data were derived from an ethnographic study conducted in two primary schools in Sweden. In order to analyse the data, grounded theory methodology was adapted. The analysis resulted in a category system of school rules, containing the following main categories: (a) relational rules, (b) structuring rules, (c), protecting rules, (d), personal rules and (e) etiquette rules. In the light of this categorisation, more consciously pedagogical and professional work with rules can be conducted. The category system can counteract vagueness and unreasonableness, as well as highlighting the content, logic and functions of different school rules.

  • 12.
    Andriolo, Alessandro
    et al.
    University of Padova, Italy.
    Battini, Dania
    University of Padova, Italy.
    Grubbström, Robert W.
    Linköping University, Department of Management and Engineering, Production Economics. Linköping University, The Institute of Technology.
    Persona, Alessandro
    University of Padova, Italy.
    Sgarbossa, Fabio
    University of Padova, Italy.
    A century of evolution from Harriss basic lot size model: Survey and research agenda2014In: International Journal of Production Economics, ISSN 0925-5273, Vol. 155, 16-38 p.Article in journal (Refereed)
    Abstract [en]

    Determining the economic lot size has always represented one of the most important issues in production planning. This problem has long attracted the attention of researchers, and several models have been developed to meet requirements at minimum cost. In this paper we explore and discuss the evolution of these models during one hundred years of history, starting from the basic model developed by Harris in 1913, up to today. Following Harriss work, a number of researchers have devised extensions that incorporate additional considerations. The evolution of EOQ theory strongly reflects the development of industrial systems over the past century. Here we outline all the research areas faced in the past by conducting a holistic analysis of 219 selected journal papers and trying to give a comprehensive view of past work on the EOQ problem. Finally, a new research agenda is proposed and discussed.

  • 13.
    Desai, Avni
    et al.
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    Widgren, Maria
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering.
    A Collaboration in Product Service System for Telecom Networks: An "Orange and Ericsson case" study2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    The purpose of the research is to study the “Orange and Ericsson case” while developing the method Actors and System Map. The interaction between actors within Ericsson’s Device Connection Platform is investigated in order to identify improvement opportunities in the interaction between the provider and the customer. To answer the purpose the following research questions was formulated:

    RQ1)  What type of actors may be involved in a telecom related IPSO?

    RQ2)  How can the connections between actors in the telecom related IPSO be illustrated?

    RQ3)  How can the Actors and System Map method be refined?

    In order to answer the research questions different methodologies were used for the analysing process. The research started with a widespread literature study to collect knowledge related to the area of Product Service System (PSS) and methodologies for identifying how actors interact with one another. Studying different mapping methods the conclusion was made that Actors and System Map was most suitable for this study.

    In the methodology background the previous selected method, Actors and System Map from an Integrated Product Service Offering (IPSO) perspective, was examined in order to be able to refine and improve the mapping method. Actors Map provides a visual and clear overview of the actors involved while a System Map shows the information flows and activities between the actors.

    To understand the interaction between the two companies, the definition of IPSO and the importance of value-based selling for a service offering are described in the theory background. Also, different ways of looking at a business model within the telecommunication industry is presented.

    Obtaining information regarding making an Actors Map and a System Map an improved mapping method was refined. The adaption of the method was divided into eight steps. The refined Actors Maps of the DCP shows the actors involved, how they are connected and their main assignments from each respondent’s point of view at Ericsson. The refined System Map shows what kind of information is transferred between the actors within the companies and between Orange and Ericsson. Both maps delivered as a decision basis will help identification of non-value giving links and non-optimal distances in the information flow for both companies.

  • 14.
    Maz´ya, Vladimir
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Mathematics, Applied Mathematics.
    Shaposhnikova, Tatyana
    Linköping University, Department of Mathematics, Applied Mathematics. Linköping University, The Institute of Technology.
    A Collection of sharp dilation invariant integral inequalities for differentiable functions2008In: Sobolev Spaces in Mathematics I. Sobolev Type Inequalities / [ed] Vladimir Maz’ya, Berlin, Heidelberg: Springer , 2008, 223-248 p.Chapter in book (Other academic)
    Abstract [en]

    Presentation of new results on the latest topics of the theory of Sobolev spaces, partial differential equations, analysis and mathematical physics

    • The authors and editors are world-renowned specialists, working in different countries
    • Publication on the centenary of Sobolev’s birth with two short biographical articles and unique archive photos of S. Sobolev which have not yet been published in the English-language literature

    This volume is dedicated to the centenary of the outstanding mathematician of the XXth century Sergey Sobolev and, in a sense, to his celebrated work On a theorem of functional analysis published in 1938, exactly 70 years ago, where the original Sobolev inequality was proved. This double event is a good case to gather experts for presenting the latest results on the study of Sobolev inequalities which play a fundamental role in analysis, the theory of partial differential equations, mathematical physics, and differential geometry. In particular, the following topics are discussed: Sobolev type inequalities on manifolds and metric measure spaces, traces, inequalities with weights, unfamiliar settings of Sobolev type inequalities, Sobolev mappings between manifolds and vector spaces, properties of maximal functions in Sobolev spaces, the sharpness of constants in inequalities, etc. The volume opens with a nice survey reminiscence My Love Affair with the Sobolev Inequality by David R. Adams.

  • 15.
    Johansson, Kajsa
    et al.
    Linköping University, Department of Medicine and Health Sciences, Physiotherapy. Linköping University, Faculty of Health Sciences.
    Öberg, Birgitta
    Linköping University, Department of Medicine and Health Sciences, Physiotherapy. Linköping University, Faculty of Health Sciences.
    Adolfsson, Lars
    Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
    Foldevi, Mats
    Linköping University, Department of Medicine and Health Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Central County Primary Health Care.
    A combination of systematic review and clinicians’ beliefs in interventions for subacromial pain2002In: British Journal of General Practice, ISSN 0960-1643, Vol. 52, no 475, 145-152 p.Article in journal (Refereed)
    Abstract [en]

    The aim of the study is to determine which treatments for patients with subacromial pain are trusted by general practitioners (GPs) and physiotherapists, and to compare trusted treatments with evidence from a systematic critical review of the scientific literature. A two-step process was used: a questionnaire (written case simulation) and a systematic critical review. The questionnaire was mailed to 18 GPs and 71 physiotherapists in Sweden. The total response rate was 72% (186/259). The following treatments were trusted: ergonomics/adjustments at work, corticosteroids, non-steroidal anti-inflamatory drugs, movement exercises, acupuncture, ultrasound therapy, strengthening exercises, stretching, transcutaneous electric nerve stimulation, and superficial heat or ice therapy. The review, including efficacy studies for the treatments found to be trusted, was conducted using the CINAHL, EMBASE and MEDLINE databases. Evidence for efficacy was recorded in relation to methodological quality and to diagnostic criteria that labelled participants as having subacromial pain or a non-specific shoulder disorder. Forty studies were included. The methodological quality varied and only one treatment had definitive evidence for efficacy for non-specific patients, namely injection of corticosteroids. The trust in corticosteroids, injected in the subacromial bursa, was supported by definitive evidence for short-term efficacy. Acupuncture had tentative evidence for short-term efficacy in patients with subacromial pain. Ultrasound therapy was ineffective for subacromial pain. This is supported by tentative evidence and, together with earlier reviews, this questions both the trust in the treatment and its use. The clinicians' trust in treatments had a weak association with available scientific evidence.

  • 16.
    Arumskog, Pär
    Linköping University, Department of Physics, Chemistry and Biology, Plasma and Coating Physics. Linköping University, The Institute of Technology.
    A Combinatorial Chemistry Approach to the Amorphous Al-In-Zn-O Transparent Oxide Semiconductor System2012Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This report describes the successful application of a combinatorial chemistry approach to the evaluation of the amorphous transparent oxide semiconductor Al-In-Zn-O, a-AIZO, for use as channel layers in thin film transistors, TFTs. Many technologies, such as computing and electronic displays, rely on the use of the transistor. In particular, for flat panel displays, the development of new TFTs for the control electronics are necessary for thinner displays with better resolution. In addition, transparent materials deposited at low temperatures would enable a new range of applications. To accomplish this, new materials for the TFT channel layer are needed.

    Transparent oxide semiconductors (TOS) are one alternative the silicon based materials currently in use and the first TOS, amorphous In-Ga-Zn-O, has just gone into production. However, despite its good properties, it suffers from the disadvantage of containing the scarce and expensive metals In and Ga. Several attempts have been made to replace Ga with Al but no systematic study of a-AIZO has been reported. This report describes such a study, using a method known as combinatorial chemistry.

    Initially, a-AIZO thin films with composition gradients were deposited by DC/RF magnetron sputtering and, following characterization, TFTs with a variety of a-AIZO channel layer composition were manufactured and investigated. Two different compositional areas were found to yield TFTs with good characteristics.

  • 17.
    Hansen, Peo
    Linköping University, REMESO - Institute for Research on Migration, Ethnicity and Society. Linköping University, Department of Thematic Studies. Linköping University, Faculty of Arts and Sciences.
    A Common Market, a Common ‘Problem’: Migration andEuropean Integration Before and After the Launching of the Single Market2005Report (Other (popular science, discussion, etc.))
    Abstract [en]

    Since the ratification of the Amsterdam Treaty in 1999 the European Union is emerging as a key actor within migration policy. But in order to understand the current development it is important to have a clear picture of the EU’s historical trajectory in the field of migration. In this paper the discussion thus focus esexclusively on the pre-Amsterdam era. It sets out with a brief historical overview of the early decades of European integration and accounts for labour migration’s crucial function in the founding logic of the EEC. While supranational competence over migration policy was very limited during this period, the discussion shows that the way in which competence was allocated between supranational and national levels would be highly consequential for the future development. Following this, the major part of the paper is devoted to an examination of the Community’s transformation during the second half of 1980s and the first half of the 1990s. The measures introduced under the banner of the Single Market, particularly those pertaining to the free movement of persons, instigated a development whereby immigration and asylum would be progressively treated as ‘common’ Community matters. Equally important, the paper shows that Community activity in the area of migration also addressed a range of other matters, many of which went beyond the issue of people moving across external and internal borders. From then on, Brussels began to address the situation of ethnic minorities of migrant background, thus bringing the growing problems of ethnic exclusion and racism on to the EU agenda. On the whole, it was the question of how to better ‘integrate’ ‘legal immigrants’ and ethnic minorities into Community societies that received the most attention. In this fashion, the present paper examines the EU’s interventions in the area of immigration and asylum together with its efforts in the realm of migrant ‘integration’. Although very few accounts have undertaken to analyze jointly the EU’s approaches to immigration and migrant ‘integration’, this paper demonstrates that in order to provide a comprehensive analysis of the issues in question, these policy areas need to be approached as inextricably intertwined and as mutually conditioning.

  • 18.
    Hildebrand, Cisilia
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Hörtin, Stina
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    A comparative study between Emme and Visum with respect to public transport assignment2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Macroscopic traffic simulations are widely used in the world in order to provide assistance in the traffic infrastructure development as well as for the strategic traffic planning. When studying a large traffic network macroscopic traffic simulation can be used to model current and future traffic situations. The two most common software used for traffic simulation in Sweden today are Emme and Visum, developed by INRO respective PTV.

    The aim of the thesis is to perform a comparison between the software Emme and Visum with respect to the assignment of public transport, in other words how passengers choose their routes on the existing public transport lines. However, in order to make a complete software comparison the run-time, analysis capabilities, multi-modality, capacity to model various behavioural phenomena like crowding, fares etc. this will not be done in this comparison. It is of interest to study the differences between the two software algorithms and why they might occur because the Swedish Transport Administration uses Emme and the Traffic Administration in Stockholm uses Visum when planning public transport. The comparison will include the resulting volumes on transit lines, travel times, flow through specific nodes, number of boarding, auxiliary volumes and number of transits. The goal of this work is to answer the following objective: What are the differences with modelling a public transport network in Emme and in Visum, based on that the passengers only have information about the travel times and the line frequency, and why does the differences occur?

    In order to evaluate how the algorithms work in a larger network, Nacka municipality (in Stockholm) and the new metro route between Nacka Forum and Kungsträdgården have been used. The motivation for choosing this area and case is due to that it is interesting to see what differences could occur between the programs when there is a major change in the traffic network.

    The network of Nacka, and parts of Stockholm City, has been developed from an existing road network of Sweden and then restricted by "cutting out" the area of interest and then removing all public transportation lines outside the selected area. The OD-matrix was also limited and in order not to loose the correct flow of travellers portal zones was used to collect and retain volumes.

    To find out why the differences occur the headway-based algorithms in each software were studied carefully. An example of a small and simple network (consisting of only a start and end node) has been used to demonstrate and show how the algorithms work and why volumes split differently on the existing transit lines in Emme and Visum. The limited network of Nacka shows how the different software may produce different results in a larger public transport network.

    The results show that there are differences between the program algorithms but the significance varies depending on which output is being studied and the size of the network. The Visum algorithm results in more total boardings, i.e. more passengers have an optimal strategy including a transit. The algorithms are very similar in both software programs, since they include more or less parts of the optimal strategy. The parameters used are taken more or less into consideration in Emme and Visum. For example Visum will first of all focus on the shortest total travel time and then consider the other lines with respect to the maximum waiting time. Emme however, first focuses on the shortest travel time and then considers the total travel time for other lines with half the waiting time instead of the maximum wait time. This results in that less transit lines will be attractive in Emme compared to Visum. The thesis concludes that varying the parameters for public transport in each software algorithm one can obtain similar results, which implies that it is most important to choose the best parameter values and not to choose the "best" software when simulating a traffic network.

  • 19.
    Götherström, Ulla-Christel
    et al.
    Linköping University, Department of Department of Health and Society, Center for Medical Technology Assessment. Linköping University, The Institute of Technology.
    Persson, Jan
    Linköping University, Department of Department of Health and Society, Center for Medical Technology Assessment. Linköping University, The Institute of Technology.
    Jonsson, Dick
    Linköping University, Department of Department of Health and Society, Center for Medical Technology Assessment. Linköping University, The Institute of Technology.
    A comparative study of text telephone and videophone relay services2004In: Technology and Disability, ISSN 1055-4181, Vol. 16, no 2, 101-109 p.Article in journal (Refereed)
    Abstract [en]

    The aim of the study was to compare text telephone relay service and videophone relay service. The target group was people borne deaf. The following aspects were investigated: (1) socioeconomic costs, (2) costs of different actors, (3) qualitative aspects of the services, (4) outcomes (intermediate effects and quality of life). The study was longitudinal and measurements were made at three occasions. Data collection was made by post-mailed questionnaires. Of the 41 respondents, 16 persons had access to the text telephone relay service only and 25 persons had access to text telephone relay service supplemented with videophone relay service. The ratings of the quality of the services and the outcomes were significantly higher for videophone relay service than for text telephone relay service (at a 95%-level). The incremental cost was approximately SEK 40 000, or EUR 4 510 (1 EUR = 8.87 SEK, as of 31 December 2000) higher per person and year for the group with access to both text telephone relay service and videophone relay service compared with the group with access to text telephone relay service only.

  • 20.
    Vogel, K
    Swedish Natl Rd & Transport Res Inst, S-58195 Linkoping, Sweden.
    A comparison of headway and time to collision as safety indicators2003In: Accident Analysis and Prevention, ISSN 0001-4575, Vol. 35, no 3, 427-433 p.Article in journal (Refereed)
    Abstract [en]

    The two safety indicators "headway" and "time to collision (TTC)" are discussed and compared with respect to their usefulness in determining the safety of different traffic situations, like different locations in a junction. Over a 6-day-period traffic flow measures were taken in a four-way junction with stop signs on the minor road. It was found that for vehicles in a car following situation headway and TTC are independent of each other. The percentage of small headways is relatively constant across different locations in the junction, while the percentage of small TTC values varies between different locations. It is recommended to use headway for enforcement purposes, because small headways generate potentially dangerous situations. TTC, on the other hand, should be used when a certain traffic environment is to be evaluated in terms of safety, because it indicates the actual occurrences of dangerous situations. (C) 2002 Elsevier Science Ltd. All rights reserved.

  • 21.
    Edlund, Ulf
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Mechanical Engineering, Engineering Mechanics.
    Volgers, Pieter
    A composite ply failure model based on continuum damage mechanics2004In: Composite structures, ISSN 0263-8223, Vol. 65, no 3-4, 347-355 p.Article in journal (Refereed)
    Abstract [en]

    A material model including the failure behaviour is derived for a thin unidirectional (UD) composite ply. The model is derived within a thermodynamic framework and the failure behaviour is modelled using continuum damage mechanics. The following features describe the model: (i) The ply is assumed to be in a plane state of stress. (ii) Three damage variables associated with the stress in the fibre-, transverse and shear directions, respectively, are used. (iii) The plastic behaviour of the matrix material is modelled. (iv) The difference in the material response in tensile and compressive loading is modelled. (v) Rate dependent behavior of plasticity and damage (i.e. strength) is modelled.

  • 22.
    Peng, Huatao
    et al.
    Wuhan University of Technology, Peoples R China.
    Liu, Yang
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Hubei University of Technology, Peoples R China; University of Vaasa, Finland.
    A comprehensive analysis of cleaner production policies in China2016In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 135, 1138-1149 p.Article in journal (Refereed)
    Abstract [en]

    Studies of cleaner production have often focused on two domains: the applications and the effects. An ever-increasing importance of cleaner production is pushing researchers to pay more attention to the formulation and principles of cleaner production policies. However, there is nearly none of the previous research that systematically and comprehensively analyses the development processes of cleaner production policies and exploring their characteristics deeply. The missing study is important in not only contributing to the perfection of cleaner production policies but also influencing the strategic planning of firms. This paper bridges this gap by first presenting a comprehensive study of the development process of cleaner production policies and then exploring their characteristics. We choose China, the biggest developing country and one of the most challenging countries to implement cleaner production, as the main research target and in addition a number of other developed and developing countries for comparisons. To investigate deeper into the characteristics of cleaner production in China, all the major policies and regulations issued by central ministries from 1997 to 2013 have been studied, ensuring the accuracy and reliability of the research. By employing T-LAB software with linguistic and statistical content analysis method, this paper derives following conclusions. (1) "audit", "implementation" and "environmental" have the highest correlation coefficients with cleaner production; (2) cleaner production policies focus on four themes: "pilot", "indicator", "people" and "list"; (3) the formulation and implementation of cleaner production policies are endowed with typical characteristics of collaboration; (4) the characteristics of cleaner production policies are typically constraining types that evidently guide and regulate the behaviours of firms. This paper contributes as a general important reference of cleaner production policies for governments and firms especially in developing countries. (C) 2016 Elsevier Ltd. All rights reserved.

    The full text will be freely available from 2018-07-01 11:04
  • 23.
    Shamsudin, Nebil
    Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology.
    A Device for Measurement of Capillary Refilling Time2012Independent thesis Advanced level (degree of Master (Two Years)), 80 credits / 120 HE creditsStudent thesis
    Abstract [en]

    The main objective of this project is to design, construct and validate a portable prototype of a device that is capable of performing a test to accurately measure Capillary Refilling Time (CRT), and to analyze the results with defined parameters; force, area, pressure (compression) and time. This prototype is dedicated to study and evaluate CRT readouts for different pressure values, collected from healthy subjects.The presented prototype of this study is capable of producing skin compressing and to measure the refilling time of capillaries following this compression. This prototype introduces accuracy, mechanical reproducibility and controlling options for the applied pressure and compression time. The presented prototype is non-invasive, portable and it can be used to conduct more CRT tests and other capillary refilling studies.CRT measurement is done by calculating time interval starting from the first point when the applied pressure is released; ending with the recording point at the time when the concentration of red blood cells has reached the level of its pre-occlusion values.Based on the calculated CRT values and the number of iterations of the test in CRT tables, one can observe that given the same applied pressure value, CRT values do not significantly vary when the test is repetitively conducted on the same subject and on the same site.

  • 24.
    Friström, Björn
    et al.
    Linköping University, Department of Neuroscience and Locomotion, Ophthalmology. Linköping University, Faculty of Health Sciences.
    Nilsson, Sven Erik G.
    Linköping University, Department of Neuroscience and Locomotion, Ophthalmology. Linköping University, Faculty of Health Sciences.
    A double masked comparison of the intraocular pressure reducing effect of latanoprost 0.005% and 0.001% administered once daily in open angle glaucoma and ocular hypertension1997In: British Journal of Ophthalmology, ISSN 0007-1161, E-ISSN 1468-2079, Vol. 81, no 10, 867-870 p.Article in journal (Refereed)
    Abstract [en]

    AIM To compare the intraocular pressure (IOP) reducing effect of latanoprost 0.005% and 0.001%.

    METHODS Twenty four patients with glaucoma or ocular hypertension were randomised into two groups. Twelve patients (group 1) were given latanoprost 0.005% once daily for 4 weeks and then latanoprost 0.001% once daily for the following 4 weeks. Twelve patients (group 2) were given latanoprost 0.001% once daily for 4 weeks and then latanoprost 0.005% for the following 4 weeks.

    RESULTS There was a significant IOP reduction from baseline in both groups on day 28 as well as on day 56. When the results from both groups were used for calculations, the mean IOP reduction from baseline after 4 weeks of treatment with latanoprost 0.005% (day 28 or 56) was 9.6 (SD 3.3) mm Hg (35.0%). After 4 weeks of treatment with latanoprost 0.001%, the IOP reduction (day 28 or 56) was 7.6 (3.4) mm Hg (27.7%). The difference in IOP reduction between the two concentrations was 2.0 (2.3) mm Hg (p<0.001).

    CONCLUSIONS Latanoprost 0.005% was more effective than latanoprost 0.001% in reducing IOP. Even the lower concentration was surprisingly effective, and potentially may be of importance for use in clinical practice. Furthermore, it is at present unknown whether the increase in iris pigmentation seen in certain patients treated with latanoprost 0.005% is dose dependent and might be less pronounced with latanoprost 0.001%. Long term studies with a larger number of patients are required in order to answer this question.

  • 25.
    Loden, M
    et al.
    ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
    Andersson, AC
    Anderson, C
    Östergötlands Läns Landsting.
    Bergbrant, IM
    ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
    Frodin, T
    Östergötlands Läns Landsting.
    Ohman, H
    Östergötlands Läns Landsting.
    Sandstrom, MH
    Sarnhult, T
    ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
    Voog, E
    ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
    Stenberg, B
    ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
    Pawlik, E
    ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
    Preisler-Haggqvist, A
    ACO Hud AB, Stockholm, Sweden Univ Uppsala Hosp, Uppsala, Sweden Linkoping Univ Hosp, S-58185 Linkoping, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Umea Univ Hosp, S-90185 Umea, Sweden Malmo Univ Hosp, Malmo, Sweden Karolinska Inst, Stockholm, Sweden.
    Svensson, A
    Lindberg, M
    A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients2002In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 82, no 1, 45-47 p.Article in journal (Refereed)
    Abstract [en]

    Moisturizing creams have beneficial effects in the treatment of dry, scaly skin, but they may induce adverse skin reactions. In a randomized double-blind study, 197 patients with atopic dermatitis were treated with one of the following: a new moisturizing cream with 20% glycerin, its cream base without glycerin as placebo, or a cream with 4% urea and 4% sodium chloride. The patients were asked to apply the cream at least once daily for 30 days. Adverse skin reactions and changes in skin dryness were assessed by the patient and a dermatologist. Adverse skin reactions such as smarting (a sharp local superficial sensation) were felt significantly less among patients using the 20% glycerin cream compared with the urea-saline cream, because 10% of the patients judged the smarting as severe or moderate when using glycerin cream, whereas 24% did so using urea-saline cream (p

  • 26.
    Eriksson, Katarina
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Obstetrics and gynecology. Linköping University, Faculty of Health Sciences.
    Carlsson, Bodil
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Microbiology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Microbiology.
    Forsum, Urban
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Clinical Microbiology. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Microbiology.
    Larsson, P-G
    Department of Obstetrics and Gynecology, Central Hospital of Sko¨vde, Sweden.
    A double-blind treatment study of bacterial vaginosis with normal vaginal lactobacilli after an open treatment with vaginal clindamycin ovules2005In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 85, no 1, 42-46 p.Article in journal (Refereed)
    Abstract [en]

    The expected 4-week cure rate after conventional treatment of bacterial vaginosis are only 65-70%. In an attempt to improve the cure rate by adding probiotic lactobacilli we performed a double-blind placebo-controlled study of adjuvant lactobacilli treatment after an open treatment with vaginal clindamycin ovules. Women with bacterial vaginosis as defined by Amsel's criteria were treated with clindamycin ovules. Vaginal smears were collected and analysed according to Nugent's criteria. During the following menstruation period the women used, as an adjuvant treatment, either lactobacilli-prepared tampons or placebo tampons. The lactobacilli tampons were loaded with a mixture of freeze-dried L. fermentum, L. casei var. rhamnosus and L. gasseri. The cure rate was recorded after the second menstruation period. There was no improvement in the cure rate after treatment with lactobacilli-containing tampons compared to placebo tampons, the cure rates as defined by Amsel's criteria were 56% and 62%, respectively, and 55% and 63%, as defined by Nugent's criteria. This is the first study to report cure rates for women with 'intermediate' wet smear ratings according to Nugent's classification and this group had an overall cure rate of 44%. The cure rate of treatment of bacterial vaginosis was not improved by using lactobacilli-prepared tampons for one menstruation.

  • 27.
    Gotoh, Fumiko
    et al.
    University of Tsukuba.
    Kikuchi, Tadashi
    University of Tsukuba, Tsukuba.
    Olofsson, Ulrich
    Linköping University, Department of Behavioural Sciences and Learning. Linköping University, Faculty of Arts and Sciences.
    A facilitative effect of negative affective valence on working memory2010In: SCANDINAVIAN JOURNAL OF PSYCHOLOGY, ISSN 0036-5564, Vol. 51, no 3, 185-191 p.Article in journal (Refereed)
    Abstract [en]

    Previous studies have shown that negatively valenced information impaired working memory performance due to an attention-capturing effect. The present study examined whether negative valence could also facilitate working memory. Affective words (negative, neutral, positive) were used as retro-cues in a working memory task that required participants to remember colors at different spatial locations on a computer screen. Following the cue, a target detection task was used to either shift attention to a different location or keep attention at the same location as the retro-cue. Finally, participants were required to discriminate the cued color from a set of distractors. It was found that negative cues yielded shorter response times (RTs) in the attention-shift condition and longer RTs in the attention-stay condition, compared with neutral and positive cues. The results suggest that negative affective valence may enhance working memory performance (RTs), provided that attention can be disengaged.

  • 28.
    Khayyeri, Hanifeh
    et al.
    Lund University, Sweden.
    Gustafsson, Anna
    Lund University, Sweden.
    Heuijerjans, Ashley
    Eindhoven University of Technology, Netherlands.
    Matikainen, Marko K.
    Lappeenranta University of Technology, Finland.
    Julkunen, Petro
    Kuopio University Hospital, Finland; University of Eastern Finland, Finland.
    Eliasson, Pernilla
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
    Aspenberg, Per
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Orthopaedics in Linköping.
    Isaksson, Hanna
    Lund University, Sweden.
    A Fibre-Reinforced Poroviscoelastic Model Accurately Describes the Biomechanical Behaviour of the Rat Achilles Tendon2015In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, no 6, e0126869Article in journal (Refereed)
    Abstract [en]

    Background Computational models of Achilles tendons can help understanding how healthy tendons are affected by repetitive loading and how the different tissue constituents contribute to the tendons biomechanical response. However, available models of Achilles tendon are limited in their description of the hierarchical multi-structural composition of the tissue. This study hypothesised that a poroviscoelastic fibre-reinforced model, previously successful in capturing cartilage biomechanical behaviour, can depict the biomechanical behaviour of the rat Achilles tendon found experimentally. Materials and Methods We developed a new material model of the Achilles tendon, which considers the tendons main constituents namely: water, proteoglycan matrix and collagen fibres. A hyperelastic formulation of the proteoglycan matrix enabled computations of large deformations of the tendon, and collagen fibres were modelled as viscoelastic. Specimen-specific finite element models were created of 9 rat Achilles tendons from an animal experiment and simulations were carried out following a repetitive tensile loading protocol. The material model parameters were calibrated against data from the rats by minimising the root mean squared error (RMS) between experimental force data and model output. Results and Conclusions All specimen models were successfully fitted to experimental data with high accuracy (RMS 0.42-1.02). Additional simulations predicted more compliant and soft tendon behaviour at reduced strain-rates compared to higher strain-rates that produce a stiff and brittle tendon response. Stress-relaxation simulations exhibited strain-dependent stress-relaxation behaviour where larger strains produced slower relaxation rates compared to smaller strain levels. Our simulations showed that the collagen fibres in the Achilles tendon are the main load-bearing component during tensile loading, where the orientation of the collagen fibres plays an important role for the tendons viscoelastic response. In conclusion, this model can capture the repetitive loading and unloading behaviour of intact and healthy Achilles tendons, which is a critical first step towards understanding tendon homeostasis and function as this biomechanical response changes in diseased tendons.

  • 29.
    Nilsson, Lennart
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Pediatrics. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
    Faldella, Giacomo
    Instituto Clinico di Pediatri,a Bologna, Spanien.
    Jacquet, Jeanne-Marie
    GlaxoSmithKline Belgium.
    Storsaeter, Jann
    GlaxoSmithKline Solna, Sverige.
    Silfverdahl, Sven-Arne
    Barnkliniken, Örebro.
    Ekholm, Leif
    BVC, Örebro.
    A fourth dose of DTPa-IPV vaccine given to 4-6 year old children in Italy and Sweden following primary vaccination at 3, 5 and 11-12 months of age2005In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 37, no 3, 221-229 p.Article in journal (Refereed)
    Abstract [en]

    Healthy 4-6 y old children from Italy and Sweden immunized with DTPa and inactivated or oral polio vaccines at 3, 5 and 11-12 months of age, received 1 dose of combined DTPa-IPV (n = 211) or DTPa+IPV as separate doses (n = 205) in a randomized trial. The pre-booster seroprotection rates were similar in each group and were above 60% against all antigens except diphtheria (31.3% and 37.0%) and PT (21.5% and 25.9%) in the DTPa-IPV and DTPa+IPV groups, respectively. At least 99.5% of subjects had seroprotective antibody levels against diphtheria, tetanus and polioviruses and ≥96% showed a vaccine response to each pertussis antigen after vaccination. Post-booster antibody levels increased at least 51-fold for anti-diphtheria and anti-tetanus, at least 18-fold for anti-pertussis antibodies and at least 32-fold for antibodies against all 3 poliovirus types, compared to prior levels. DTPa-IPV was comparable to DTPa+IPV in terms of seroprotection rates and mean antibody levels against each vaccine antigen. Similar reactogenicity profiles were observed between groups including swelling >50 mm [13% (9.1, 18.7) vs 17% (12.4, 23.4)] or involving an adjacent joint [0% (-,-) vs 1.5% (0.3, 4.3)] and were consistent with previous reports. The combined DTPa-IPV vaccine could be used to add DTP valences to the IPV vaccine currently given to children in Scandinavia and Italy at 4-6 y of age and reinforce protection against 4 diseases. © 2005 Taylor & Francis.

  • 30.
    Vitoria, Aida
    Linköping University, Department of Science and Technology, Visual Information Technology and Applications (VITA). Linköping University, The Institute of Technology.
    A framework for reasoning with rough sets2005Licentiate thesis, monograph (Other academic)
    Abstract [en]

    Rough sets framework has two appealing aspects. First, it is a mathematical approach to deal with vague concepts. Second, rough set techniques can be used in data analysis to find patterns hidden in the data. The number of applications of rough sets to practical problems in different fields demonstrates the increasing interest in this framework and its applicability.

    Most of the current rough sets techniques and software systems based on them only consider rough sets defined explicitly by concrete examples given in tabular form. The previous research mostly disregards the following two problems. The first problem is related with how to define rough sets in terms of other rough sets. The second problem is related with how to incorporate domain or expert knowledge.

    This thesis proposes a language that caters for implicit definitions of rough sets obtained by combining different regions of other rough sets. In this way, concept approximations can be derived by taking into account domain knowledge. A declarative semantics for the language is also discussed. It is then shown that programs in the proposed language can be compiled to extended logic programs under the paraconsistent stable model semantics. The equivalence between the declarative semantics of the language and the declarative semantics of the compiled programs is proved. This transformation provides the computational basis for implementing our ideas. A query language for retrieving information about the concepts represented through the defined rough sets is also defined. Several motivating applications are described. Finally, an extension of the proposed language with numerical measures is discussed. This extension is motivated by the fact that numerical measures are an important aspect in data mining applications.

  • 31.
    Liu, Zhenxia
    et al.
    Linköping University, Department of Mathematics, Mathematical Statistics . Linköping University, Faculty of Science & Engineering.
    Wang, Zhi
    Ningbo University of Technology, Peoples R China.
    Yang, Xiangfeng
    Linköping University, Department of Mathematics, Mathematical Statistics . Linköping University, Faculty of Science & Engineering.
    A Gaussian expectation product inequality2017In: Statistics and Probability Letters, ISSN 0167-7152, E-ISSN 1879-2103, Vol. 124Article in journal (Refereed)
    Abstract [en]

    Let (X-1,. . ., X-n) be any n-dimensional centered Gaussian random vector, in this note the following expectation product inequality is proved: E Pi (n)(j=1) f(j)( X-j) amp;gt;= Pi (n)(j=1) Ef(j)(X-j) for functionsh, 1 amp;lt;= j amp;lt;= n, taking the forms f(j)(x) = integral(infinity)(0) where mu(j), 1 amp;lt;= j amp;lt;= n, are finite positive measures. The motivation of studying such an inequality comes from the Gaussian correlation conjecture (which was recently proved) and the Gaussian moment product conjecture (which is still unsolved). Several explicit examples of such functions f(j) are given. The proof is built on characteristic functions of Gaussian random variables. (C) 2017 Elsevier B.V. All rights reserved.

  • 32.
    Fogelberg Eriksson, Anna
    Linköping University, Department of Behavioural Sciences and Learning, Education and Sociology. Linköping University, Department of Behavioural Sciences and Learning, Work and Working Life. Linköping University, Faculty of Arts and Sciences. Linköping University, HELIX Vinn Excellence Centre.
    A gender perspective as trigger and facilitator of innovation2014In: International Journal of Gender and Entrepreneurship, ISSN 1756-6266, Vol. 6, no 2, 163-180 p.Article in journal (Refereed)
    Abstract [en]

    Purpose – The purpose of this paper is to explore whether a gender perspective contributes to or functions as a driving force for innovations in organizations. The following questions are addressed: how can a gender perspective generate innovations and what are the conditions that favour innovations driven by a gender perspective?

    Design/methodology/approach – This study builds on a qualitative case study of an upper secondary school in Sweden, which has been showcased as a good example of gender awareness and gender mainstreaming in schools. Semi-structured interviews with representatives of the school were conducted and documents were analysed.

    Findings – The gender perspective contributed to innovations by triggering them and supporting the innovative processes, ensuring that the innovations did not stop at essentialist solutions. New ways of performing core processes were developed with the innovative leverage of the gender perspective. The perspective must be actively used and integrated into the core processes if it is to work properly, which was the case in this school.

    Research limitations/implications – This study indicates the importance of conducting further studies on innovations in the public sector as well as acknowledging gender in innovation studies, not least because this study focuses on a local case in a specific national context.

    Practical implications – This school exemplifies the use of a gender perspective as a driving force for innovations in organizations. The case points to important organizational conditions for innovation and actual gender-aware innovations.

    Originality/value – The study expands the understanding of innovation(s) in organizations and elaborates on the gendered dimensions of innovation as both process and product.

  • 33.
    Edell-Gustafsson, Ulla
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Nursing Science.
    Svanborg, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Neuroscience and Locomotion, Clinical Neurophysiology. Östergötlands Läns Landsting, Reconstruction Centre, Department of Neurophysiology UHL.
    Swahn, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    A gender perspective on sleeplessness behavior, effects of sleep loss, and coping resources in patients with stable coronary artery disease2006In: Heart & Lung, ISSN 0147-9563, Vol. 35, no 2, 75-89 p.Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The primary aim of this study was to systematically compare perceived sleep quality, sleeplessness behavior, sense of mastery, self-esteem, depression, subjective health, and effects of sleep loss in men and women with stable coronary artery disease (CAD). Further aims were to determine possible predictors of poor sleep quality and sense of mastery, as well as the consequences of too little sleep. METHODS: Comparative-correlation and predictive design were used. Patients with a history of stable angina pectoris scheduled to undergo coronary angiography at Linköping University Hospital in Sweden were included. There were 47 women and 88 men (mean age 62.4 years) with CAD. Structured interviews using validated questionnaires covered sleep quality and sleep habits, effects of sleep loss, psychologic resources, and depression. RESULTS: Multiple stepwise regression analysis showed that sleeplessness behavior, depressed mood, female gender, and pharmacologic treatments with inflammation inhibitors significantly (P < .0001) accounted for the variance of poorer sleep quality. The analysis also showed that the following factors in descending order significantly accounted (P < .0001) for the outcome of sleep quality: inability to feel refreshed by sleep, difficulty in maintaining sleep, gastrointestinal problems, too little sleep, final morning awakening time, sleep onset latency, lying down because of daytime tiredness, and daytime physical tiredness. CONCLUSIONS: Compared with men, women with stable CAD may be especially at risk of experiencing poor sleep quality, even when sleeplessness behavior and pharmacologic treatments with inflammation inhibitors are controlled. It is also possible that they may be more at risk of depressed mood. Copyright © 2006 by Mosby, Inc.

  • 34.
    Burdakov, Oleg
    Parallel Algorithms Team, CERFACS, Toulouse Cedex, France.
    A greedy algorithm for the optimal basis problem1997In: BIT Numerical Mathematics, ISSN 0006-3835, E-ISSN 1572-9125, Vol. 37, no 3, 591-599 p.Article in journal (Refereed)
    Abstract [en]

    The following problem is considered. Given m+1 points {x i }0 m in R n which generate an m-dimensional linear manifold, construct for this manifold a maximally linearly independent basis that consists of vectors of the form x i x j . This problem is present in, e.g., stable variants of the secant and interpolation methods, where it is required to approximate the Jacobian matrix f′ of a nonlinear mappingf by using values off computed at m+1 points. In this case, it is also desirable to have a combination of finite differences with maximal linear independence. As a natural measure of linear independence, we consider the hadamard condition number which is minimized to find an optimal combination of m pairs {x i ,x j }. We show that the problem is not NP-hard, but can be reduced to the minimum spanning tree problem, which is solved by the greedy algorithm in O(m 2) time. The complexity of this reduction is equivalent to one m×n matrix-matrix multiplication, and according to the Coppersmith-Winograd estimate, is below O(n 2.376) for m=n. Applications of the algorithm to interpolation methods are discussed.

  • 35.
    Berggren, Karl
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    A high sensitivity imaging detector for the study of the formation of (anti)hydrogen2013Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    AEGIS (Antimatter Experiment, Gravity, Interferometry and Spectroscopy) isan experiment under development at CERN which will measure earth's gravitationalforce on antimatter. This will be done by creating a horizontal pulsedbeam of low energy antihydrogen, an atom consisting of an antiproton anda positron. The experiment will measure the vertical de ection of the beamthrough which it is possible to calculate the gravitational constant for antimatter.To characterise the production process in the current state of the experimentit is necessary to develop an imaging detector for single excited hydrogenatoms. This thesis covers the design phase of that detector and includes studiesand tests of detector components. Following literature studies, tests and havingdiscarded several potential designs, a baseline design was chosen. The suggesteddetector will contain a set of ionising rings followed by an electron multiplyingmicrochannel plate, a light emitting phosphor screen, a lens system and nallya CCD camera for readout. The detector will be able to detect single hydrogenatoms, measure their time of ight as well as being able to image electronplasmas and measure the time of ight of the initial particles in such a plasma.Tests were made to determine the behaviour of microchannel plates at the lowtemperatures used in the experiment. Especially, the resistance and multiplicationfactor of the microchannel plates have been measured at temperaturesdown to 14 K.

  • 36.
    Philipson, O.
    et al.
    Uppsala University.
    Hammarström, Per
    Linköping University, Department of Physics, Chemistry and Biology, Biochemistry. Linköping University, The Institute of Technology.
    Nilsson, Peter
    Linköping University, Department of Physics, Chemistry and Biology, Organic Chemistry. Linköping University, The Institute of Technology.
    Portelius, E.
    Sahlgrenska University Hospital.
    Olofsson, T.
    Uppsala University.
    Ingelsson, M.
    Uppsala University.
    Hyman, B.T.
    Massachusetts General Hospital.
    Blennow, K.
    Sahlgrenska University Hospital.
    Lannfelt, L.
    Uppsala University.
    Kalimo, H.
    Uppsala University.
    Nilsson, L.N.G.
    Uppsala University.
    A highly insoluble state of Aβ similar to that of Alzheimers disease brain is found in Arctic APP transgenic mice2009In: Neurobiology of Aging, ISSN 0197-4580, Vol. 30, no 9, 1393-1405 p.Article in journal (Refereed)
    Abstract [en]

    Amyloid-β (Aβ) is a major drug target in Alzheimers disease. Here, we demonstrate that deposited Aβ is SDS insoluble in tgAPP-ArcSwe, a transgenic mouse model harboring the Arctic (E693G) and Swedish (KM670/671NL) APP mutations. Formic acid was needed to extract the majority of deposited Aβ in both tgAPP-ArcSwe and Alzheimers disease brain, but not in a commonly used type of mouse model with the Swedish mutation alone. Interestingly, the insoluble state of Arctic Aβ was determined early on and did not gradually evolve with time. In tgAPP-ArcSwe, Aβ plaques displayed a patchy morphology with bundles of Aβ fibrils, whereas amyloid cores in tgAPP-Swe were circular with radiating fibrils. Amyloid was more densely stacked in tgAPP-ArcSwe, as demonstrated with a conformation sensitive probe. A reduced increase in plasma Aβ was observed following acute administration of an Aβ antibody in tgAPP-ArcSwe, results that might imply reduced brain to plasma Aβ efflux. TgAPP-ArcSwe, with its insoluble state of deposited Aβ, could serve as a complementary model to better predict the outcome of clinical trials.

  • 37.
    Lunneryd, Sven Gunnar
    et al.
    National Board of Fisheries, Tja¨rno¨ Marine Biological Laboratory, SE-452 96 Strömstad, Sweden.
    Fjälling, Arne
    Linköping University, Department of Physics, Chemistry and Biology, Zoology . Linköping University, The Institute of Technology.
    Westerberg, Håkan
    National Board of Fisheries, Box 423, SE-401 26 Gothenburg, Sweden..
    A large-mesh salmon trap: a way of mitigating seal impact on a coastal fishery2003In: ICES Journal of Marine Science, ISSN 1054-3139, E-ISSN 1095-9289, Vol. 60, no 6, 1194-1199 p.Article in journal (Refereed)
    Abstract [en]

    A new design for a salmon trap aimed at minimizing damage to catch and gear caused by grey seals was tested. The traditional trap design used in the northern Baltic permits an efficient hunting strategy by seals, whereby chased fish entangle themselves in the side panels and can then easily be taken, with associated damage to the net. The side panels of the test trap (excluding the fish chamber) are made of large-mesh (400 mm) netting compared to ≤200 mm in traditional traps. This should allow seal-chased and panicking salmon to pass through, while less stressed individuals should still be guided efficiently towards the fish chamber. Trials with the two trap types were performed at the mouth of the river Indal (northern Sweden) in a comparative test programme. Catches of salmon and trout in the test trap were larger than in the standard trap. We estimated that 65% of the potential catch was lost in the standard trap owing to seal predation, while escape rate through the large meshes in the test trap was 52%. The standard trap had a total of 269 holes owing to seal damage, while only six holes were found in the test trap. Seal activity in and around the standard trap was up to 16 times higher compared with the test trap and decreased considerably during the following year when only large-meshed traps were used in the area. We suggest that seals are difficult to deter from fishing gear as long as they get a reward in terms of food and propose that a strategy that deprives seals of a reward will make the gear uninteresting to them and may have long-term mitigation effects.

  • 38.
    Gupta, Anil
    et al.
    Linköping University, Department of Medical and Health Sciences, Anesthesiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Anaesthesiology and Surgery UHL.
    Favaios, S.
    EPE.
    Perniola, A.
    Orebro University Hospital.
    Magnuson, A.
    University Orebro.
    Berggren, L.
    Orebro University Hospital.
    A meta-analysis of the efficacy of wound catheters for post-operative pain management2011In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 55, no 7, 785-796 p.Article, review/survey (Refereed)
    Abstract [en]

    Local anesthetics (LA) are injected via catheters placed in surgical wounds for post-operative analgesia. The primary aim of this systematic review was to assess whether LA reduce pain intensity when injected via wound catheters. A literature search was performed from Medline via PubMed, EMBASE and the Cochrane database from 1966 until November 2009. The search strategy included the following key words: pain, postoperative, catheters and local anesthetics. Two co-authors independently read every article that was initially included and extracted data into a pre-defined study record form. A total of 753 studies primarily fit the search criteria and 163 were initially extracted. Of these, 32 studies were included in the meta-analysis. Wound catheters provided no significant analgesia at rest or on activity, except in patients undergoing gynecological and obstetric surgery at 48 h (P = 0.03). The overall morphine consumption was lower (approximate to 13 mg) during 0-24 h (P less than 0.001) in these patients. No significant differences in side effects were found, except for a lower risk of wound breakdown (P = 0.048) and a shorter length of hospital stay (P = 0.04) in patients receiving LA. A statistically significant heterogeneity was seen between the studies in most end-points. LA injected via wound catheters did not reduce pain intensity, except at 48 h in a subgroup of patients undergoing obstetric and gynecological surgery. Rescue analgesic consumption was also lower in this group at 0-24 h. The magnitude of these effects was small and compounded by pronounced heterogeneity.

  • 39.
    Köhn, Dagmar
    et al.
    Institute for Computer Science Universität Rostock.
    Strömbäck, Lena
    Linköping University, The Institute of Technology. Linköping University, Department of Computer and Information Science, IISLAB - Laboratory for Intelligent Information Systems.
    A method for Semi-automatic Standard Integration in Systems Biology2008In: Database and Expert Systems Applications,2008, Heidelberg, Germany: Springer , 2008, 745-752 p.Conference paper (Refereed)
    Abstract [en]

    The development of standards for biological pathways has led to a huge amount of model data stored in a variety of different formats represented in XML (e. g. SBML) or OWL (e. g. BioPAX). As a result, there is an urgent need for the conversion of data between different formats, especially between XML and OWL data. The fact that that transformation is hard to realize hampers the integration of data in the area. Addressing this problem, the following article proposes a general, semi-automatic solution by suggesting the transformation of XML Schema based data into an OWL format. The general solution presented here will support biologists by offering them a way to query data of any format and as well compare different data files or schemas to each other using OWL as a common format for matching and providing a backwards transformation to XML Schema. The paper presents a first architectural approach and its prototype implementation. The evaluation showed that the approach is promising.

  • 40.
    Gustafsson, J
    et al.
    Östergötlands Läns Landsting.
    Kalvemark, S
    Apoteket AB.
    Nilsson, G
    Örebro University.
    Nilsson, JLG
    NEPI Foundation.
    A method to evaluate patient information leaflets2003In: Drug information journal, ISSN 0092-8615, Vol. 37, no 1, 115-125 p.Article in journal (Refereed)
    Abstract [en]

    The aim of this study was to develop a useful method for evaluating patient information leaflets by comparing the result of expert and patient evaluations. The hypothesis was that if there was a correlation between the results of these evaluations it would be acceptable to only do expert review for patient information leaflets currently in use. Experts and patients examined patient information leaflets from 30 common medicines, following European Union Directive 92/27 EEC, which outlined the legal requirements for patient information leaflets. The scoring system allowed a direct comparison between the outcomes of expert and patient examinations. We found a significant correlation between the expert and patient examinations of the content of the patient information leaflets. We conclude that patient information leaflets that score above average on the expert examination of content (ie, adherence to the directive) will also score above the average on the patient examination.

  • 41.
    Norrlöf, Mikael
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gunnarsson, Svante
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Model Based Iterative Learning Control Method Applied to 3 Axes of a Commercial Industrial Robot2000In: Proceedings of the 6th IFAC Symposium on Robot Control, 2000Conference paper (Refereed)
    Abstract [en]

    A synthesis algorithm for the filters in a first order ILC is presented and applied on an industrial robot. The proposed ILC synthesis method is evaluated using two experiments on the robot. The first is a one-axis experiment where the system can be seen as a single servo. A modeling experiment is done to give input to the synthesis algorithm and then ILC is applied to the single axis showing a dramatic improvement in trajectory following. In the second experiment ILC is applied to a more complex multi axes motion where the robot draws a circle in a plane. The evaluation of the result is done using a pen mounted on the robot and it is evident that also on the arm-side an improved motion can be achieved. In both experiments the error converges to a stable level in about 5 iterations. Since a model is desired for the synthesis, an extra iteration has to be done for the modeling experiment. In this particular case a good path following can therefore be achieved after 6 iterations.

  • 42.
    Norrlöf, Mikael
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gunnarsson, Svante
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Model Based Iterative Learning Control Method Applied to an Industrial Robot1999Report (Other academic)
    Abstract [en]

    A synthesis algorithm for the filters in a first order ILC is presented and applied on an industrial robot. The proposed ILC synthesis method is evaluated using two experiments on the robot. The first is a one-axis experiment where the system can be seen as a single servo. A modeling experiment is done to give input to the synthesis algorithm and then ILC is applied to the single axis showing a dramatic improvement in trajectory following. In the second experiment ILC is applied to a more complex multi axes motion where the robot draws a circle in a plane. The evaluation of the result is done using a pen mounted on the robot and it is evident that also on the arm-side an improved motion can be achieved. In both experiments the error converges to a stable level in about 5 iterations. Since a model is desired for the synthesis, an extra iteration has to be done for the modeling experiment. In this particular case a good path following can therefore be achieved after 6 iterations.

  • 43.
    Gunnarsson, Svante
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Norrlöf, Mikael
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Model Based Iterative Learning Control Method Applied to an Industrial Robot1999In: Proceedings of the Second Conference on Computer Science and Systems Engineering, 1999Conference paper (Other academic)
    Abstract [en]

    A synthesis algorithm for the filters in a first order ILC is presented and applied on an industrial robot. The proposed ILC synthesis method is evaluated using two experiments on the robot. The first is a one-axis experiment where the system can be seen as a single servo. A modeling experiment is done to give input to the synthesis algorithm and then ILC is applied to the single axis showing a dramatic improvement in trajectory following. In the second experiment ILC is applied to a more complex multi axes motion where the robot draws a circle in a plane. The evaluation of the result is done using a pen mounted on the robot and it is evident that also on the arm-side an improved motion can be achieved. In both experiments the error converges to a stable level in about 5 iterations. Since a model is desired for the synthesis, an extra iteration has to be done for the modeling experiment. In this particular case a good path following can therefore be achieved after 6 iterations.

  • 44.
    Norrlöf, Mikael
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gunnarsson, Svante
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Model Based Iterative Learning Control Method Applied to an Industrial Robot2000In: Proceedings of Reglermöte 2000, 2000, 73-78 p.Conference paper (Other academic)
    Abstract [en]

    A synthesis algorithm for the filters in a first order ILC is presented and applied on an industrial robot. The proposed ILC synthesis method is evaluated using two experiments on the robot. The first is a one-axis experiment where the system can be seen as a single servo. A modeling experiment is done to give input to the synthesis algorithm and then ILC is applied to the single axis showing a dramatic improvement in trajectory following. In the second experiment ILC is applied to a more complex multi axes motion where the robot draws a circle in a plane. The evaluation of the result is done using a pen mounted on the robot and it is evident that also on the arm-side an improved motion can be achieved. In both experiments the error converges to a stable level in about 5 iterations. Since a model is desired for the synthesis, an extra iteration has to be done for the modeling experiment. In this particular case a good path following can therefore be achieved after 6 iterations.

  • 45.
    Wijma, Barbro
    et al.
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gender and Medicine. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Gynecology and Obstetrics in Linköping.
    Engman, Maria
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gender and Medicine.
    Wijma, Klaas
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine, Gender and Medicine.
    A model for critical review of literature - With vaginismus as an example2007In: Journal of Psychosomatic Obstetrics and Gynaecology, ISSN 0167-482X, Vol. 28, no 1, 21-36 p.Article in journal (Refereed)
    Abstract [en]

    In this article we present a behavioral model for the critical review of the literature within a certain research field, using vaginismus as an example. We searched the literature for the title word "vaginismus" and analyzed to what extent the articles dealt with the following seven categories: prevention, etiology, maintaining factors, consequences, object of intervention, method of intervention, and method of evaluation. In each category we scrutinized the content of the articles for biological, psychological, social, relational, and gender aspects. Quality requirements of etiological and treatment studies were then added and the results presented in a "quality-adjusted" model. There were 102 articles during 1985-2001, of which 22 were included in the review. Most of the articles deal with supposed predisposing factors of etiology and different aspects of intervention. Only a few articles discuss precipitating factors, maintaining factors, or consequences of the problem. No article had a gender analysis. Only 11 of the articles fulfilled some of the proposed quality criteria. We found the behavioral model with quality requirements useful for classifying and evaluating the literature of vaginismus. The model may also be used as a guide to design methodologically good studies. © 2007 Informa UK Ltd.

  • 46.
    Olstam, Johan
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    A model for simulation and generation of surrounding vehicles in driving simulators2005Licentiate thesis, monograph (Other academic)
    Abstract [en]

    Driving simulators are used to conduct experiments on for example driver behavior, road design, and vehicle characteristics. The results of the experiments often depend on the traffic conditions. One example is the evaluation of cellular phones and how they affect driving behavior. It is clear that the ability to use phones when driving depends on traffic intensity and composition, and that realistic experiments in driving simulators therefore has to include surrounding traffic.

    This thesis describes a model that generates and simulates surrounding vehicles for a driving simulator. The proposed model generates a traffic stream, corresponding to a given target flow and simulates realistic interactions between vehicles. The model is built on established techniques for time-driven microscopic simulation of traffic and uses an approach of only simulating the closest neighborhood of the driving simulator vehicle. In our model this closest neighborhood is divided into one inner region and two outer regions. Vehicles in the inner region are simulated according to advanced behavioral models while vehicles in the outer regions are updated according to a less time-consuming model. The presented work includes a new framework for generating and simulating vehicles within a moving area. It also includes the development of enhanced models for car-following and overtaking and a simple mesoscopic traffic model.

    The developed model has been integrated and tested within the VTI Driving simulator III. A driving simulator experiment has been performed in order to check if the participants observe the behavior of the simulated vehicles as realistic or not. The results were promising but they also indicated that enhancements could be made. The model has also been validated on the number of vehicles that catches up with the driving simulator vehicle and vice versa. The agreement is good for active and passive catch-ups on rural roads and for passive catch-ups on freeways, but less good for active catch-ups on freeways.

  • 47.
    Mobini, Reza
    et al.
    Unit for Clinical Systems Biology, Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden.
    Andersson, Bengt A.
    Department of Immunology, Sahlgrenska Academy, Gothenburg, Sweden.
    Erjefält, Jonas
    Department of Experimental Medicine, Lund University, Lund, Sweden.
    Hahn-Zoric, Mirjana
    Department of Immunology, Sahlgrenska Academy, Gothenburg, Sweden.
    Langston, Michael A.
    Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN, USA.
    Perkins, Andy D.
    Department of Electrical Engineering and Computer Science, University of Tennessee, Knoxville, TN, USA.
    Cardell, Lars Olaf
    Department of Oto-rhino-largyngeology, Karolinska Institute, Stockholm, Sweden.
    Benson, Mikael
    Unit for Clinical Systems Biology, Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden.
    A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation2009In: BMC Systems Biology, ISSN 1752-0509, Vol. 3, no 19Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The identification of novel genes by high-throughput studies of complex diseases is complicated by the large number of potential genes. However, since disease-associated genes tend to interact, one solution is to arrange them in modules based on co-expression data and known gene interactions. The hypothesis of this study was that such a module could be a) found and validated in allergic disease and b) used to find and validate one ore more novel disease-associated genes.

    RESULTS: To test these hypotheses integrated analysis of a large number of gene expression microarray experiments from different forms of allergy was performed. This led to the identification of an experimentally validated reference gene that was used to construct a module of co-expressed and interacting genes. This module was validated in an independent material, by replicating the expression changes in allergen-challenged CD4+ cells. Moreover, the changes were reversed following treatment with corticosteroids. The module contained several novel disease-associated genes, of which the one with the highest number of interactions with known disease genes, IL7R, was selected for further validation. The expression levels of IL7R in allergen challenged CD4+ cells decreased following challenge but increased after treatment. This suggested an inhibitory role, which was confirmed by functional studies.

    CONCLUSION: We propose that a module-based analytical strategy is generally applicable to find novel genes in complex diseases.

  • 48.
    Stenkula, Karin
    Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
    A molecular approach to insulin signalling and caveolae in primary adipocytes2007Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The prevalence of type II diabetes is increasing at an alarming rate due to the western world lifestyle. Type II diabetes is characterized by an insulin resistance distinguished by impaired glucose uptake in adipose and muscle tissues. The molecular mechanisms behind the insulin recistance and also the knowledge considering normal insulin signalling in fat cells, especially in humans, are still unclear.

    Insulin receptor substrate (IRS) is known to be important for medating the insulin-induced signal from the insulin receptor into the cell. We developed and optimized a method for transfection of primary human adipocytes by electroporation. By recombinant expression of proteins, we found a proper IRS to be crucial for both mitogenic and metabolic signalling in human adipocytes. In human, but not rat, primary adipocytes we found IRS1 to be located at the plasma membrane in non-insulin stimulated cells. Insulin stimulation resulted in a two-fold increase of the amount of IRS1 at the plasma membrane in human cells, compared with a 12-fold increase in rat cells. By recombinant expression of IRS1 we found the species difference between human and rat IRS1 to depend on the IRS proteins and not on properties of the host cell.

    The adipocytes function as an energy store, critical for maintaining the energy balance, and obesity strongly correlates with insulin resistance. The insulin sensitivity of the adipocytes with regard to the size of the cells was examined by separating small and large cells from the same subject. We found no increase of the GLUT4 translocation to the plasma membrane following insulin stimulation in the large cells, whereas there was a two-fold increase in the small cells. This finding supports the idea of a causal relationship between the enlarged fat cells and reduced insulin sensitivity found in obese subjects.

    The insulin receptor is located and functional in a specific membrane structure, the caveola. The morphology of the caveola and the localization of the caveolar marker proteins caveolin-1 and -2 were examined. Caveolae were shown to be connected to the exterior by a narrow neck. Caveolin was found to be located at the neck region of caveolae, which imply importance of caveolin for maintaining and sequestering caveolae to the plasma membrane.

    In conclusion, the transfection technique proved to be highly useful for molecular biological studies of insulin signal transduction and morphology in primary adipocytes.

    List of papers
    1. Expression of a mutant IRS inhibits metabolic and mitogenic signalling of insulin in human adipocytes
    Open this publication in new window or tab >>Expression of a mutant IRS inhibits metabolic and mitogenic signalling of insulin in human adipocytes
    Show others...
    2004 (English)In: Molecular and Cellular Endocrinology, ISSN 0303-7207, Vol. 221, no 1-2, 1-8 p.Article in journal (Refereed) Published
    Abstract [en]

    Adipose tissue is a primary target of insulin, but knowledge about insulin signalling in human adipocytes is limited. We developed an electroporation technique for transfection of primary human adipocytes with a transfection efficiency of 15% ± 5 (mean ± S.D.). Human adipocytes were co-transfected with a mutant of IRS-3 (all four potential PI3-kinase binding motifs mutated: IRS-3F4) and HA-tagged protein kinase B (HA-PKB/Akt). HA-PKB/Akt was immunoprecipitated from cell lysates with anti-HA antibodies, resolved with SDS-PAGE, and immunoblotted with phospho-specific antibodies. We found that IRS-3F4 blocked insulin stimulation of HA-PKB/Akt phosphorylation and in further analyses also translocation of recombinant HA-tagged glucose transporter to the plasma membrane. IRS-3F4 also blocked insulin-induced activation of the transcription factor Elk-1. Our results demonstrate the critical importance of IRS for metabolic as well as mitogenic signalling by insulin. This method for transfection of primary human adipocytes will be useful for studying insulin signalling in human adipocytes with molecular biological techniques.

    Keyword
    Insulin, Transfection, Human, Adipocytes, Protein kinase B, Elk-1
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14538 (URN)10.1016/j.mce.2004.04.011 (DOI)000222854100001 ()
    Available from: 2007-06-01 Created: 2007-06-01 Last updated: 2013-10-22Bibliographically approved
    2. Cell surface orifices of caveolae and localization of caveolin to the necks of caveolae in adipocytes
    Open this publication in new window or tab >>Cell surface orifices of caveolae and localization of caveolin to the necks of caveolae in adipocytes
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    2003 (English)In: Molecular Biology of the Cell, ISSN 1059-1524, E-ISSN 1939-4586, Vol. 14, no 10, 3967-3976 p.Article in journal (Refereed) Published
    Abstract [en]

    Caveolae are noncoated invaginations of the plasma membrane that form in the presence of the protein caveolin. Caveolae are found in most cells, but are especially abundant in adipocytes. By high-resolution electron microscopy of plasma membrane sheets the detailed structure of individual caveolae of primary rat adipocytes was examined. Caveolin-1 and -2 binding was restricted to the membrane proximal region, such as the ducts or necks attaching the caveolar bulb to the membrane. This was confirmed by transfection with myc-tagged caveolin-1 and -2. Essentially the same results were obtained with human fibroblasts. Hence caveolin does not form the caveolar bulb in these cells, but rather the neck and may thus act to retain the caveolar constituents, indicating how caveolin participates in the formation of caveolae. Caveolae, randomly distributed over the plasma membrane, were very heterogeneous, varying in size between 25 and 150 nm. There was about one million caveolae in an adipocyte, which increased the surface area of the plasma membrane by 50%. Half of the caveolae, those larger than 50 nm, had access to the outside of the cell via ducts and 20-nm orifices at the cell surface. The rest of the caveolae, those smaller than 50 nm, were not open to the cell exterior. Cholesterol depletion destroyed both caveolae and the cell surface orifices.

    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14539 (URN)10.1091/mbc.E03-01-0050 (DOI)
    Available from: 2007-06-01 Created: 2007-06-01 Last updated: 2013-09-10
    3. Human, but not rat, IRS1 targets to the plasma membrane in both human and rat primary adipocytes
    Open this publication in new window or tab >>Human, but not rat, IRS1 targets to the plasma membrane in both human and rat primary adipocytes
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    2007 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, Vol. 363, no 3, 840-845 p.Article in journal (Refereed) Published
    Abstract [en]

    Adipocytes are primary targets for insulin control of metabolism. The activated insulin receptor phosphorylates insulin receptor substrate-1 (IRS1), which acts as a docking protein for downstream signal mediators. In the absence of insulin stimulation, IRS1 in rat adipocytes is intracellular but in human adipocytes IRS1 is constitutively targeted to the plasma membrane. Stimulation of adipocytes with insulin increased the amount of IRS1 at the plasma membrane 2-fold in human adipocytes, but >10-fold in rat adipocytes, with the same final amount of IRS1 at the plasma membrane in cells from both species. Cross-transfection of rat adipocytes with human IRS1, or human adipocytes with rat IRS1, demonstrated that the species difference was due to the IRS1 protein and not the cellular milieus or posttranslational modifications. Chimeric IRS1, consisting of the conserved N-terminus of rat IRS1 with the variable C-terminal of human IRS1, did not target the plasma membrane, indicating that subtle sequence differences direct human IRS1 to the plasma membrane.

    Keyword
    Insulin receptor substrate; Human; Rat; Insulin; Plasma membrane; Signaling; Transfection; Caveolae
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14540 (URN)10.1016/j.bbrc.2007.09.065 (DOI)
    Available from: 2007-06-01 Created: 2007-06-01 Last updated: 2013-09-10
    4. Insulin-induced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual
    Open this publication in new window or tab >>Insulin-induced GLUT4 translocation to the plasma membrane is blunted in large compared with small primary fat cells isolated from the same individual
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    2007 (English)In: Diabetologia, ISSN 0012-186X, Vol. 50, no 8, 1716-1722 p.Article in journal (Refereed) Published
    Abstract [en]

    Aims/hypothesis: Several studies have suggested that large fat cells are less responsive to insulin than small fat cells. However, in these studies, large fat cells from obese individuals were compared with smaller fat cells from leaner participants, in effect making it impossible to draw conclusions about whether there is a causal relationship between fat cell size and insulin sensitivity. We hypothesised that small fat cells might be more insulin-responsive than large adipocytes when obtained from the same individual.

    Materials and methods: We developed a method of sorting isolated primary human fat cells by using nylon filters of two different pore sizes. The cells were stained to visualise DNA, which allowed discrimination from artefacts such as lipid droplets. The sorted cells were left to recover overnight, since we had previously demonstrated that this is necessary for correct assessment of insulin response.

    Results: We found similar amounts of the insulin receptor (IR), IRS-1 and GLUT4 when we compared small and large adipocytes from the same volunteer by immunoblotting experiments using the same total cell volume from both cell populations. Activation of IR, IRS-1 and Akt1 (also known as protein kinase B) by insulin was similar in the two cell populations. However, immunofluorescence confocal microscopy of plasma membrane sheets did not reveal any increase in the amount of GLUT4 in the plasma membrane following insulin stimulation in the large fat cells, whereas we saw a twofold increase in the amount of GLUT4 in the small fat cells.

    Conclusions/interpretation: Our results support a causal relationship between the accumulation of large fat cells in obese individuals and reduced insulin responsiveness.

    Keyword
    Adipocyte, GLUT4, Human, Insulin, Insulin receptor, Insulin resistance, IRS-1, Primary fat cell
    National Category
    Medical and Health Sciences
    Identifiers
    urn:nbn:se:liu:diva-14541 (URN)10.1007/s00125-007-0713-1 (DOI)
    Available from: 2007-06-01 Created: 2007-06-01 Last updated: 2013-09-10Bibliographically approved
  • 49.
    Ullman, Gustaf
    et al.
    Linköping University, Center for Medical Image Science and Visualization, CMIV. Linköping University, Department of Medicine and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences.
    Dance, David R.
    Royal Surrey County Hospital, Guildford.
    Sandborg, Michael
    Linköping University, Center for Medical Image Science and Visualization, CMIV. Linköping University, Department of Medicine and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics.
    Alm Carlsson, Gudrun
    Linköping University, Center for Medical Image Science and Visualization, CMIV. Linköping University, Department of Medicine and Health Sciences, Radiation Physics. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Radiation Physics.
    Svalkvist, Angelica
    University of Gothenburg.
    Båth, Magnus
    University of Gothenburg.
    A Monte Carlo-based model for simulation of digital chest tomosynthesis2010In: Radiation Protection Dosimetry, ISSN 0144-8420, E-ISSN 1742-3406, Vol. 139, no 1-3, 159-163 p.Article in journal (Refereed)
    Abstract [en]

    The aim of this work was to calculate synthetic digital chest tomosynthesis projections using a computer simulation model based on the Monte Carlo method. An anthropomorphic chest phantom was scanned in a computed tomography scanner, segmented and included in the computer model to allow for simulation of realistic high-resolution X-ray images. The input parameters to the model were adapted to correspond to the VolumeRAD chest tomosynthesis system from GE Healthcare. Sixty tomosynthesis projections were calculated with projection angles ranging from +15 to −15°. The images from primary photons were calculated using an analytical model of the anti-scatter grid and a pre-calculated detector response function. The contributions from scattered photons were calculated using an in-house Monte Carlo-based model employing a number of variance reduction techniques such as the collision density estimator. Tomographic section images were reconstructed by transferring the simulated projections into the VolumeRAD system. The reconstruction was performed for three types of images using: (i) noise-free primary projections, (ii) primary projections including contributions from scattered photons and (iii) projections as in (ii) with added correlated noise. The simulated section images were compared with corresponding section images from projections taken with the real, anthropomorphic phantom from which the digital voxel phantom was originally created. The present article describes a work in progress aiming towards developing a model intended for optimisation of chest tomosynthesis, allowing for simulation of both existing and future chest tomosynthesis systems.

  • 50.
    Sandewall, Erik
    Linköping University, Department of Computer and Information Science, CASL - Cognitive Autonomous Systems Laboratory. Linköping University, The Institute of Technology.
    A Neo-Classical Structure for Scientific Publication and Reviewing1997Report (Other academic)
    Abstract [en]

    I propose a neo-classical structure for publishing and reviewing of scientific works. This proposal has the following characteristic components:

    • Electronic “preprint archives” and other similar mechanisms where research articles are made publicly available without prior formal review are considered as true and full-fledged publication of research from the point of view of priority of results.
    • Large parts of the reviewing process is done publicly and in the form of published review letters and other contributions to the scientific debate, rather than through anonymous and confidential review statements which dominate today. There is a switch from anonymous “pass-fail” reviewing towards open reviewing where the identity and the comments of the reviewers are made public.
    • Since open reviewing happens after publication, rather than before, there is a second step where articles are promoted to “recommended” or “certified” status through the decision of a review committee. The requirements for certification are set at least as high as for the formally published journal articles of today, so that it counts like journal publication in a CV.
    • Several techniques are foreseen for facilitating the selection process of the individual reader as well as for improving communication as such between researchers.
    • One should accept that there are good reasons why there may be several articles (from the same author) presenting the same result. This suggests the introduction of a formal concept of a “result” which is represented by several publications, and to allow citations to refer to results rather than to some specific publication of the result.

    I refer to this system as neo-classical because it assumes that peer review is done openly and after an article has been published. It is of course only proposed as a complement which can easily co-exist with the modern system, allowing each author to choose which of the two systems he or she wishes to use for a particular article.

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