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  • 1.
    Léb Lehrman, Susanne
    et al.
    Linköping University, Department of Behavioural Sciences and Learning.
    Algebrant, Marita
    Linköping University, Department of Behavioural Sciences and Learning.
    "Jag är inte tyst och jag kan höja rösten"2008Independent thesis Advanced level (degree of Magister), 15 points / 22,5 hpStudent thesis
    Abstract [sv]

    Studien undersöker hur kvinnliga chefer inom offentlig sektor upplever sina möjligheter och hinder i karriären . Kvinnor i maktposition har motsägelsefulla roller vilket i sig kan upplevas som ett dilemma.

    Sex kvinnor på höga chefspositioner inom en offentlig sektor i Sverige deltog. Intervjuer genomfördes med en semistrukturerad intervjuguide baserad på följande områden: struktur, interaktion, individrelatering och symboler. Intervjuguidens struktur och analysen av intervjuerna baserades på en könsteoretisk modell enligt doing gender perspektiv. Doing gender perspektivet användes för att beskriva de praktiker som var av betydelse för den maktstruktur som fanns i organisationen.

    Analysen av de könsskapande processer som påvisades i organisationen, visade att det främst var värdering av kunskap, värdering av kvinnligt och manligt ledarskap och förutsättningarna för att utföra ledarskapet som utgjorde hinder eller möjligheter för kvinnornas karriär. Organisationen, med dess konserverade hierarkiska system, var också en barriär för kvinnorna.

  • 2.
    Gullberg, Erik
    Linköping University, The Department of Physics, Chemistry and Biology.
    Construction of a system for heterologous production of carbonic anhydrase from Plasmodium falciparum in Pichia pastoris2008Independent thesis Advanced level (degree of Master), 20 points / 30 hpStudent thesis
    Abstract [en]

    Malaria is one of the biggest current global health problems, and with the increasing occurance of drug resistant Plasmodium falciparum strains, there is an urgent need for new antimalarial drugs. Given the important role of carbonic anhydrase in Plasmodium falciparum (PfCA), it is a potential novel drug target. Heterologous expression of malaria proteins is problematic due to the unusual codon usage of the Plasmodium genome, so to overcome this problem a synthetic PfCA gene was designed, optimized for expression in Pichia pastoris. This gene was also modified to avoid glycosylation, and cloned into the vector pPICZαA under the control of the methanol inducible promoter AOX1. To facilitate export of the protein into the growth medium, the gene was fused in-frame with the α-factor secretion signal from Saccharomyces cerevisiae. The construct was successfully integrated in the genome of P. pastoris GS115, and attempts were made to express the protein and purify it using immobilized metal ion affinity chromatography.In this work, no expression of the PfCA protein could be detected, so further research should focus on optimization of expression conditions, or redesign of the expression vector.

  • 3.
    Larsson, Anneli
    Linköping University, The Tema Institute.
    Profile and perceptions of biogas as automobile fuel: A study of Svensk Biogas2008Independent thesis Advanced level (degree of Master), 20 points / 30 hpStudent thesis
    Abstract [en]

    From an environmental- and health perspective, biogas and other biomass-based fuels have several advantages; nevertheless the majority of motorists fill their cars with petroleum-based fuels. This thesis is designed to explore the profile of biogas in relation to its perceptions. It is a study concerning the communication between the biogas producing company Svensk Biogas and their biogas users and non biogas users. To obtain a thorough understanding of the profile and perceptions of biogas a qualitative approach was considered appropriate. Biogas users and non-users were interviewed at gasoline stations, while Svensk Biogas was interviewed as a group.

    The three interview segments were analyzed and compared in order to identify patterns, similarities and differences. Based on research data the thesis concludes that the profiling arguments of biogas correlates to that biogas is the most environmentally friendly fuel, the least expensive fuel, and locally produced. Furthermore, the company profile of Svensk Biogas is equal to sustainable alternative, locally produced, trustworthy, environmentally friendly and climate smart [klimatsmart]. Given the arguments of the company profile, environmental values seem to be the core communicating value. Profiling Svensk Biogas happens through events and by using communication material such as company logotype.

    Motorists have an overall positive perception of biogas. Biogas users states environmental benefits as the key argument behind their commitment. Non-users are positive toward biogas although expressing a lack of knowledge confusing biogas with ethanol and bio-fuels in general. According to motorists the negative perceptions, in addition to the prerequisites of biogas, are connected to insufficient infrastructure of biogas filling stations, a short range of the biogas tank, a high investment cost of a biogas car, a biogas price increase, scarcity of cars, and information (lack of information and misleading information).

    The overall perception of Svensk Biogas among biogas users is positive. Biogas users express a negative perception concerning the Svensk Biogas filling stations and also wish for a lower biogas price. Non-users express modest perceptions of the company. This research also concludes that perceptions of the biogas producer are correlated to the perceptions of biogas. Furthermore, biogas producer, users and non-users wish to be directed by political decisions, guiding them toward environmentally friendly fuel alternatives.

  • 4.
    Collin, Angelica
    et al.
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Hammarberg, Matilda
    Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
    Röstfaktorer som avslöjar ironi: Akustiska likheter och skillnader mellan sinnesstämningar2014Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The word irony is defined as an utterance where the meaning is the opposite of the words. This report is a continuing study of Peder Palmér's study What is ironic speech: to find the auditory clues (2013). The basis for this follow-up study consists of recordings with three different talkers with five sentences in five different moods: happiness, anger, seriousness, irony and sarcasm. Thirty men and women aged 18 to 60 years have been listening to the sentences and categorized them based on interpreted mood. The authors have measured fundamental frequency and intensity, and used these measurements as a basis to elucidate the perception of irony and the ability to perceive mood based on changes in fundamental frequency and intensity. The fundamental frequency has also been compared between the three talkers. An acoustic comparison between the different moods forms the basis for the analysis, which can provide information about the importance of acoustic parameters, as well as other factors such as context, when identifying different moods. The aim is to examine whether the moods that are most similar from an acoustic perspective are the ones that the test subjects most often fail to distinguish. The results show that it is difficult to solely from acoustic parameters interpret mood. Fundamental frequency and intensity appear to be of some importance when confusing irony with other moods. No differences were found between men and women's ability to detect irony and sarcasm based solely on acoustic parameters.

  • 5.
    Berner, Boel
    Linköping University.
    Organhandel, ekonomisk och etnisk exploatering2014In: Respons, no 2, 58-59 p.Article, book review (Other (popular science, discussion, etc.))
  • 6.
    Larsson, Lina
    Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
    Kliniskt datainsamlingssystem med beslutsstöd - Användarutredning och gränssnitt för Sahlgrenskas akutintag2005Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

     Extra high requirements are made on all systems in health care that they are functional and usable,´something, however, that is not always the case. At Emergency Admissions at Sahlgrenska University´Hospital many systems are in use at the same time and it happens that much overhead is caused by having to fill in the same information in different places. In addition, data that is gathered is to a large extent saved in free text format, which means that it cannot be used in a larger context such as research, quality control or for decision support. Data is saved in the patient file only for the treatment process of the individual patient.

    A data collecting system with decision support functionality could be a first step towards reducing Emergency Admissions’ costs and patients’ waiting times by providing a structured method of data collection. It is also possible that it could contribute to safer care for patients as the system could warn the staff on occasions where there may be a risk of a patient suffering from a serious, acute illness that might be difficult to diagnose.

    An analysis has been performed at Emergency Admissions at Sahlgrenska to distinguish possible users of a new system for collecting data with decision support. The results showed that the nurses in reception were the most suitable target group.

    A prototype of a user interface for gathering initial patient data at reception has been made at Emergency Admissions at Sahlgrenska. This prototype has decision support functionality for ranking the most probable diagnoses as well as providing advice on suitable tests and examinations to perform. The focus has been on usability and on adapting the system to the needs of the users.

    It is highly important that future users, the staff at Emergency Admissions, continue to participate in the future further development of the data gathering system so that their needs and requirements are not overshadowed by the new technology.

  • 7.
    Westin, Carl-Fredrik
    et al.
    Harvard Medical School.
    Pasternak, O.
    Harvard Medical School.
    In-vivo angular double-pfg mri of the human brain2012In: Proceddings of the ISMRM, ISMRM, 2012Conference paper (Refereed)
  • 8.
    Jaque, Cassandra
    et al.
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Johansson, Anders
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Kromatografi av polära läkemedel och metaboliter med HILIC-teknik2013Independent thesis Basic level (degree of Bachelor), 10,5 credits / 16 HE creditsStudent thesis
    Abstract [en]

    The purpose of this project was to investigate if retention of polar compounds that are given to treat tuberculosis, diabetes, inflammatory bowel disease and childhood leukemia could be obtained with HILIC separation. By varying different parameters for different types of columns the compounds were analyzed with the aim of finding guidelines for future method optimizations. To perform these analyzes three different columns were tested – ZIC-HILIC (silica-based with zwitterions), ZIC-pHILIC (polymer-based with zwitterions) and XBridge Amide (amide functions). The results were evaluated with selected quality measures. The parameters being varied were pH, temperature, flow rate, type of buffer and ionic strength. In addition, comparisons between isocratic and gradient separations were performed.

     

    Over 1 000 analyzes were conducted in which retention of 16 of total 18 substances were successfully obtained with HILIC. The columns that generated the best results in terms of greatest number of identified compounds were ZIC-HILIC and XBridge Amide. ZIC-pHILIC offered a wide pH range but generally gave inferior chromatography. The influence of the different parameters on the results has not been investigated in sufficient scope. This means that no specific methods for the different drug groups can be reported.

  • 9.
    Engström, Maria
    et al.
    Linköping University, Department of Medical and Health Sciences, Radiology.
    Karlsson, Thomas
    Linköping University, Department of Behavioural Sciences and Learning, Disability Research.
    Landtblom, Anne-Marie
    Linköping University, Department of Clinical and Experimental Medicine, Neurology.
    Craig, A. D. (Bud)
    Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, AZ.
    Mental energy: graded co-activation of the anterior insular and anterior cingulate cortices during challenging working memory,  visual perception and motor speed tasks.Manuscript (preprint) (Other academic)
  • 10.
    Weström, Sarah
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Speech and Language Pathology. Linköping University, Faculty of Health Sciences.
    Örneholm, Isabelle
    Linköping University, Department of Clinical and Experimental Medicine, Speech and Language Pathology. Linköping University, Faculty of Health Sciences.
    Interaktion och intervention: En undersökning av kommunikativa behov hos personer med afasi och dysartri i vardagliga och kliniska samtal2012Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In speech and language intervention, the ability to interact is seldom evaluated; rather intervention is evaluated in terms of improved testresults.  If goal-setting in intervention also is based on everyday communicative needs, the relevance of the treatment may be increased and intervention outcome may be implemented in the patient’s natural environment.

    The present study, as part of a research-project, is based on analyses of interaction and interviews to examine everyday conversations and speech and language intervention. The aim was to explore if there is a relation between everyday communication needs and goal-setting in speech and language intervention for people with aphasia. A further aim was to investigate if there are everyday communicative needs that may form goals for speech and language intervention.

    Two individuals with aphasia and one individual with both dysarhtria and aphasia participated in the study. Three speech and language pathologists and two relatives also participated in the study. Everyday interaction and intervention sessions were recorded and transcribed according to Conversation Analysis principles and analysed from an interactional perspective. Interviews regarding intervention and everyday communication were carried out with all participants. Recordings were presented and discussed with all participants, in so called retrospections.

    Four phenomena that illustrate communication needs of the participating patients were identified: repair, alternative and augmentative communication, co-construction and feedback. Analysis, interviews and retrospections have revealed that communication needs can form the basis of goal-setting in speech and language intervention. It is also demonstrated that intervention mainly is based on the everyday communication needs of the patient. Retrospections were also shown to be useful in order to observe communication needs in everyday life and in order to evaluate speech and language intervention. The retrospections were found to be beneficial to an open dialogue between speech and language pathologist, patient and relatives regarding the content and aim of the intervention.

     

  • 11.
    Malmström, Therese
    et al.
    Linköping University, Department of Social and Welfare Studies, Health, Activity, Care. Linköping University, Faculty of Health Sciences.
    Svedjeholm, Sanna
    Linköping University, Department of Social and Welfare Studies, Health, Activity, Care. Linköping University, Faculty of Health Sciences.
    Heteronormativitet – en begreppsanalys: ”Alla är både offer och supportrar av systemet”2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The concept heteronormativity was used in the literature for the first time in 1993. This term can be found in dictionaries and encyclopedias from 2006 but only in a few of the most modern publications. The term currently lacks an exact definition. The aim of concept analysis is to identify characteristics for a term by studying its use. Healthcare relations can and should be developed into a caring relation, which is dependent on a connection involving body, mind and soul between the caregiver and the patient. The aim of this work was to describe and deepen the understanding of the term heteronormativity from a healthcare perspective. Rodgers’ evolutionary concept analysis of 23 scientific papers and common newspapers resulted in seven defined attributes: assumptions, norms, social hierarchies, sanctions for those deviating from the norm, gender roles, sexual relationships and stereotype family apprehension. The analysis also identified what precedes the concept, two women working with the concept and five related concepts: equality, gender, power, discrimination and homophobia. A number of consequences of which all were negative for both individuals and the society were found. Healthcare is negatively influenced in several ways by heteronormativity rendering the caring relation impossible. Conclusion: Heteronormativity leads to a number of problems and everyone are both victims and supporters of the system.

  • 12.
    Ardi, Sonay
    Linköping University, Department of Computer and Information Science. Linköping University, Faculty of Arts and Sciences.
    Quality of Life of Elderly People in Iran: With Sevice Design Approach2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    In the aging world of today, more attentions are grabbed towards studies on elderly. New facilities and technologies are emerged to serve to the elderly, maketheir life easier, better and more useful. Having participated in a study on thequality of life of the elderly in Europe, it was aimed to run a similar project toresearch the quality of life of the elderly in a Non-EU country. This was donethrough the research questions “What is the quality of life for them?” and “Howa designer, focused on service design, can improve their quality of life?”The knowledge for the study was obtained from fields Quality of Life of ElderlyPeople, Service Design, Service Design Process, and Qualitative Research. As thekey country for this study, Iran was chosen. Study on the target group in thiscountry was done through Cultural Probes and in analyzing the probes, Processfor Empathy in Design was used. To visualize the results of the target group study,Affinity Diagrams and Personas were drawn.The result was designing a service for the target group, which is presented byConcept Scenario, Storyboards, System Maps and Blueprints. In this concept,called “Virtual Family”, the personas are encouraged to be members of a networkwhich is supported by an organization/community in terms of health, social life,leisure activities and educational programs. This network is forming a virtualfamily regarding the traditional values and ethics which are important for thisage group. Additionally it supports them with entertainment and educationalprograms. Later on, the service concept was evaluated by a number of people inthe same age and social group of the target group. Evaluators found the conceptan excellent complement for mentioned target group who are on the verge oflosing their family and social structure, but the organizational system of the contextcountry should be studied to know if it is planning is practical in that context.

  • 13.
    Andersson, Marie
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Speech and Language Pathology. Linköping University, Faculty of Health Sciences.
    Nordin, Elin
    Linköping University, Department of Clinical and Experimental Medicine, Speech and Language Pathology. Linköping University, Faculty of Health Sciences.
    Voice Onset Time among Children with Phonological Impairment.2012Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Speech production requires cooperation between cognitive, linguistic and motor processes. It also requires spatial and temporal control of muscles, as well as simultaneous and coordinated activity of respiration, phonation and articulation (Cheng, Murdoch, Goozée & Scott, 2007; Yorkston, Beukelman, Strand & Bell, 1999; Raphael, Borden & Harris, 2011). Voice Onset Time (VOT) reflects the timing between phonation and articulation (Hoit-Dalgaard, Murry & Kopp, 1983). VOT is the most reliable acoustic cue for distinguishing between voiceless or voiced plosives (Auzou et al. 2000). Studies of English-speaking children with phonological impairment have shown atypical VOT-patterns (Bond & Wilson, 1980). The aim of the present study was to investigate Voice Onset Time (VOT) among Swedish children with phonological impairment and to examine if their VOT-values differ from typically developed Swedish children. Participants were 38 children aged 4;2−11;6 distributed over eight age- groups and five developmental stages of phonology. Audio recordings of minimal pairs were made at preschools, schools or at speech pathology clinics. The results indicated that children with phonological impairment produced VOT with deviant values and with a great variability. A marked acoustic difference between voiceless and voiced stop consonants was present, but not in all cases. Since the VOT-values were distributed over the group of children with phonological impairment, no developmental trend toward adult-like values that could be related to increasing age was found for either the acquisition of producing VOT or the acquisition of producing voicing lead. No differences in VOT were seen between the children in different phonological developmental stages or ages. No correlation between the degree of deviance of VOT and the proportion of Procent Phonemes Correct (PPC), age or phonological processes were found. From the results the conclusion can be drawn that children with phonological impairment have deviant VOT-values that could be caused by lack of phonological knowledge, but in particular since the variability did not decrease with increased age, have difficulties with motor execution. 

  • 14.
    LIU, ZHI
    Linköping University, Department of Medical and Health Sciences, Health and Society. Linköping University, Faculty of Health Sciences.
    A Study of the Relationship between Socialization Tactics, Motives to Study and Mental Health in Chinese College Students2012Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
    Abstract [en]

    College students constitute a particular social group that carries hopes and expectations from both parents and society. However, in recent years there have been  reports about increasing problems in many universities in China: students suspension from school, skipping classes, or even committing suicide,. As social isolation, anxiety, fragility etc are possible reasons, the importance of university student’s mental health has been taken seriously more and more. University students’ socialization refers to the process in which college students grow up into independent and mature individuals by learning social and culture knowledge. From social perspective, on one hand, they still need to learn professional knowledge, on the other hand, they have to construct a good philosophy for themselves, a correct world outlook and value conception. This study mainly explores undergraduate students’ mental health in relation to socialization tactics and motives to study. That means that the focus of this survey is not on the degree of socialization, but on the tactic the students have chosen to get into the university society.

    In this study totally 120 students were examined via two questionnaires, the University Personality Inventory(UPI) introduced from Japan, and the combined Motives to Study and Socialization Tactics questionnaire from Israel. Both of them  passed homogeneity testing. The 120 students were from four universities, two  located in Hangzhou city and two in Beijing. Statistical analysis including correlation analysis, multiple regression and t-test, showed that motives to study had little to do with students’ mental health, while scholastic and collegiate socialization tactics were associated with good mental health of the students. There was no big difference in study motives and socialization tactics between the male and the female students in this study.

  • 15.
    Åman, Mikael
    et al.
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences.
    Joakim, Behrendtz
    Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences.
    Anestesipersonalens peri-operativa omvårdnad av överviktiga och obesa barn2012Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Children are a group of patients that require special knowledge from the anesthesia staff, both general and specific. Theoretical knowledge and practical experience is necessary to adequately care for the child as it anatomically, physiologically and mentally may differ from adult patients.

    A growing problem in the pediatric population is overweight and obesity. From a stagnation in the early 2000s the prevalence of overweight and obesity among children in the world are again increasing.The purpose of this study was to examine peri-operative care of overweight and obese children.

    Systematic searches were done in PubMed, CINAHL and Scopus. After the quality audit according to SBU, twelve articles were included for analysis.

    Results suggest that overweight and obese children have a higher risk of respiratory peri-operative complications. The risk of hospital admission after outpatient surgery was also greater in this group as well as higher costs for health care.

    Overweight and obese children are complex subjects with more frequent peri-operative risk factors than normal-weight children. This group requires special knowledge of the anesthesia staff. More studies are required to secure evidence in anesthetic care for overweight and obese children.

  • 16.
    Papanikolaou, Anna
    Linköping University, Department of Social and Welfare Studies. Linköping University, Faculty of Arts and Sciences.
    Att leva med ett missbruksförflutet i en drogfri vardag: En kvalitativ studie om före detta kvinnliga missbrukares erfarenheter och upplevelser av dåtid, nutid och framtid2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Studien syftar till att synliggöra och förstå hur kvinnliga före detta missbrukare berörs av ett förflutet liv i missbruk. Hur förhåller sig kvinnliga före detta missbrukare i den drogfria tillvaron till det förflutna missbruket och synen på framtiden? För att besvara mitt syfte och mina frågeställningar genomfördes fem kvalitativa intervjuer vilka analyserades med grundad teori som analysmetod. Studiens teoretiska utgångspunkter är identitet, genus och moderskap som tillsammans med tidigare forskning bidragit till att problematisera och fördjupa analysen. En av studiens slutsatser är att synen på sig själv både påverkas av den sociala omgivningen och samhälleliga föreställningar om rollen som mamma. Vad som även synliggörs är att trots att missbrukslivet är förbi och kvinnorna idag lever ett drogfritt liv gör sig det förflutna påmint på skilda sett. Exempelvis i interaktion med andra, i vissa sociala miljöer, men också i tanken på det gamla och i tanken på framtiden.

  • 17.
    Vastesson, Alexander
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Micro-Structuring of New Materials Combined with Electronic Polymers for Interfaces with Cells2012Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Materials based on novel Off-Stoichiometry Thiol-Ene polymers, abbreviated OSTE, show promising properties as materials forlow cost and scalable manufacturing of micro- and nanosystems such as lab-on-chip devices. The OSTE materials have tunablemechanical properties, offer possibility for low temperature bonding to many surfaces via tunable surface chemistry, and can beused in soft lithography. Unlike the commonly used elastomer poly(dimethylsiloxane), PDMS, the OSTE materials have lowpermeability for gasses, are resistant to common solvents and can be more permanently surface modified.In this master’s thesis project, the OSTE materials have been evaluated with focus on compatibility with cells, possibility fornanostructuring using soft lithography and the use of OSTE as a flexible support for conducting polymers.Results from cell seeding studies with HEP G2 cells suggest that cells can proliferate on a low thiol off-stoichiometry OSTEmaterial for at least five days. The biocompatibility for this type of OSTE material may be similar to poly(styrene). However, highlevels of free thiol monomers in the material decrease cell viability considerably.By using soft lithography techniques it is possible to fabricate OSTE nanochannels with at least the dimensions of 400 nm x 15nm. Combined with the advantages of using the OSTE materials, such as low temperature bonding and possibility for stablesurface modifications, a candidate construction material for future development of systems for DNA analysis is at hand.OSTE can serve as a flexible support for an adsorbed film of a conducting polymer with the possibility for future applicationssuch as electronic interfaces in microsystems. In this project, a film of PEDOT:PSS with the electrical resistance of ~5 kΩ wascreated by adsorption to an flexible OSTE material. Furthermore, results suggest that it is possible to further optimize theconductivity and water resistance of PEDOT:PSS films on OSTE.

  • 18.
    Björck, S
    et al.
    Department of Surgery, Sahlgrenska Hospital, Gothenburg.
    Enochsson, L
    Department of Surgery, Sahlgrenska Hospital, Gothenburg.
    Svanvik, Joar
    Department of Surgery, Sahlgrenska Hospital, Gothenburg.
    Commentary: the rising tide of cholecystectomy for biliary dyskinesia2013In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 37, no 4, 493-494 p.Article in journal (Other academic)
  • 19.
    Ronquist, Gunnar
    et al.
    Avdelningen för klinisk kemi, institutionen för medicinska vetenskaper, Uppsala universitet, Uppsala, Sverige.
    Lötvall, Jan
    Krefting Research Center, Göteborgs universitet, Göteborg, Sverige.
    Gabrielsson, Susanne
    Enheten för translationell immunologi, medicinkliniken, Karolinska universitetssjukhuset; Karolinska institutet, Stockholm, Sverige.
    Mincheva-Nilsson, Lucia
    Avdelningen för klinisk immunologi, institutionen för klinisk mikrobiologi, Umeå universitet, Umeå, Sverige.
    Svanvik, Joar
    Transplantationscentrum Sahlgrenska universitetssjukhuset, Göteborg, Sverige.
    Telemo, Esbjörn
    Avdelningen för reumatologi och inflammationsforskning, Göteborgs universitet, Göteborg, Sverige.
    Waldenström, Anders
    Institutionen för folkhälsa och klinisk medicin, Umeå universitet, Umeå, Sverige.
    Exosomen – intercellulär signalbärare med framtids­potential [Exosomes - intercellular signal carriers with a future potential]: Kan ge nya diagnostiska och terapeutiska möjligheter [May provide new diagnostic and therapeutic opportunities]2013In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 46, no 110, 2050-2052 p.Article in journal (Other academic)
    Abstract [en]

    Small vesicles were first described in prostatic and seminal fluids more than 30 years ago [5]. They were called prostasomes and are members of the same family now called exosomes. All cells in the body can release extracellular vesicles that function as intercellular messengers. The smallest of these, exosomes, are produced by almost all types of cells in the body and exist in all body fluids. Exosomal signalling takes place in two different ways: either with a cargo of functional proteins and/or by transfection of functional RNA molecules from one cell to the cytoplasm of another, or by ligand-receptor mediated interactions between molecules of the exosome membrane and the cellular membrane of the target cell. The importance of exosomes both in health and disease is rapidly acknowledged and clinical applications in diagnosticts and therapy are under development. The content of proteins and nucleic acids of exosomes will soon be used as bio markers for different diseases such as cancer and cardiac disease. Clinical tests are ongoing where exosomes are used as natural vectors for cancer specific peptides in the treatment of cancer. Exosomes will most probably soon be used in therapy by using them as natural vectors for new  RNA based therapies and also for follow up of therapy.

  • 20.
    Zaigham, Mehreen
    et al.
    Department of Obstetrics and Gynecology Skåne University Hospital, Institution of Clinical Sciences, Lund University, Malmö, Sweden.
    Lundberg, Fredrik
    Department of Neonatology, Skåne University Hospital, Institution of Clinical Sciences, Lund University, Malmö, Sweden.
    Hayes, Ronald
    Banyan Biomarkers Inc., Alachua, FL, USA.
    Undén, Johan
    Department of Intensive Care and Perioperative Medicine, Skåne University Hospital, Institution of Clinical Sciences, Lund University, Malmö, Sweden.
    Olofsson, Per
    Department of Obstetrics and Gynecology Skåne University Hospital, Institution of Clinical Sciences, Lund University, Malmö, Sweden.
    Umbilical cord blood concentrations of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in neonates developing hypoxic-ischemic encephalopathy.2015In: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954, Vol. 29, no 11, 1822-1828 p.Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To compare ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) concentrations in umbilical cord blood of neonates who develop Sarnat stage II-III hypoxic-ischemic encephalopathy (HIE) to healthy controls, and to relate the concentrations to the severity of neurology and long-time outcomes.

    MATERIAL AND METHODS: Cord sera of 15 neonates with HIE II-III and 31 matched controls were analyzed for UCH-L1 and GFAP. Comparisons were performed for cord artery pH, amplitude-integrated electroencephalography (aEEG), stage of HIE, and death or sequelae up to an age of 6 years. Parametric and non-parametric statistics were used with a two-sided p < 0.05 considered significant.

    RESULTS: Among controls no associations between biomarker concentrations and gestational age, birthweight, length of storage of cord sera and degree of hemolysis were found. No significant differences in biomarker concentrations were found between HIE neonates and controls, and no differences were found with regard to HIE stage, cord acidemia, severity of aEEG changes, or persistent sequelae or death.

    CONCLUSIONS: No differences in cord blood UCH-L1 and GFAP concentrations were found between HIE neonates and controls, and no associations were found between the biomarker concentrations and the severity of disease, or whether the condition developed into a permanent or fatal injury.

  • 21.
    Green, Magdalena (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20122012Report (Other academic)
  • 22.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20132013Report (Other academic)
  • 23.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20142014Report (Other academic)
  • 24.
    Alm, Anchi (Editor)
    Granit PR & Kommunikation.
    West, Emma (Editor)
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Åttonde nationella prioriterings-konferensen 2015: En summering2015Report (Other academic)
    Abstract [sv]

    Vilken väg ska prioriteringsarbetet i Sverige ta?

    Hur används den etiska plattformen för prioriteringar och behöver den utvecklas? Hur ska vi se på prioriteringar i förhållande till politik, budgetunderskott och patientinflytande? Den åttonde nationella prioriteringskonferensen, som arrangerades i Norrköping den 21-22 oktober, lyfte många intressanta frågor.

  • 25.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20062006Report (Other academic)
  • 26.
    Green, Magdalena (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20112011Report (Other academic)
  • 27.
    Bergman, Olle (Editor)
    Bergmans Bokstäver AB, Eskilstuna.
    Kernell Tolf, Malin (Editor)
    PrioriteringsCentrum, Landstinget i Östergötland.
    Prioriteringar i vården: Om konsten att bygga broar: Rapport från den femte nationella prioriteringskonferensen Malmö 15-16 oktober 20092009Report (Other academic)
    Abstract [sv]

    Öppna prioriteringar har blivit hetare än någonsin. Syftet med den femte nationella konferensen om prioriteringar är att fördjupa utbytet av kunskap och erfarenheter mellan olika aktörer och att skapa möten för debatt och dialog. Det pågår en mängd prioriteringsarbeten runt om i landet som borgar för att denna prioriteringskonferens kommer mer än föregående att präglas av praktiska erfarenheter. Vad har vi lärt oss och hur går vi vidare?

  • 28.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20072007Report (Other academic)
  • 29.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20152015Report (Other academic)
  • 30.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20092009Report (Other academic)
  • 31.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20082008Report (Other academic)
  • 32.
    Green, Magdalena (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20102010Report (Other academic)
  • 33.
    Bergman, Olle (Editor)
    Bergmans Bokstäver AB, Eskilstuna.
    Kernell Tolf, Malin (Editor)
    PrioriteringsCentrum, Landstinget i Östergötland.
    Lika vård på olika villkor: Rapport från den fjärde nationella prioriteringskonferensen, Örebro 4–5 oktober 20072007Report (Other academic)
    Abstract [sv]

    Många delar uppfattningen att befolkningens växande behov av vård och  omsorg kommer att vara större än resurserna. Likaså finns det en stor enighet om att nödvändiga prioriteringar inte skall vara godtyckliga eller slumpartade. Däremot saknas det enighet om vem som skall göra valen och hur det ska gå till.

    Det övergripande syftet med den fjärde nationella konferensen om prioriteringar var att bidra till ett fördjupat utbyte av kunskap mellan olika aktörer samt att skapa möten för debatt och dialog mellan politiker och dem som arbetar med vårdfrågor i praktiken.

  • 34.
    Bergman, Olle (Editor)
    Bergmans Bokstäver AB, Eskilstuna.
    Kernell Tolf, Malin (Editor)
    PrioriteringsCentrum, Landstinget i Östergötland.
    Lika vård på olika villkor: Rapportering från den fjärde nationella prioriteringskonferensen 3-5 oktober 20072007Report (Other academic)
    Abstract [sv]

    I den internationella sessionen fick vi ta del av hur det står till i den norska hälso- och sjukvården samt utvecklingsprojekt kring prioriteringar i Kanada. Vi fick även möjlighet att reflektera kring vilka erfarenheter vi kan ta till oss i Sverige. Medverkande vid denna session var flera personer: Elizabeth Nygaard från Sosial- og helsedirektoratet och seniorrådgivare vid Avdelningen för kvalitet och prioriteringar i Norge; Craig Mitton, Assistant Professor vid Health Studies vid University of British Columbia; Christina Kärvinge, enhetschef på Enheten för Nationella riktlinjer vid Socialstyrelsens Hälso- och sjukvårdsavdelning; Gösta Andersson, Direktör i Landstinget Dalarna samt Bo-Eric Malmvall, Verksamhetschef i Jönköpings läns landsting. Moderator var Peter Garpenby, docent vid Centrum för utvärdering av medicinsk teknologi vid Linköpings universitet samt projektledare vid PrioriteringsCentrum.

  • 35.
    Hässel, Brita (Editor)
    Hässel & Palm, Västra Frölunda.
    Green, Magdalena (Editor)
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Välfärden – en osäker resa in i framtiden?: Dokumentation från Sjätte nationella prioriteringskonferensen, Västerås 6–7 oktober 20112011Report (Other academic)
    Abstract [sv]

    Den 6:e nationella prioriteringskonferensen genomfördes i Västerås den 6–7 oktober. Som vanligt innebar det ett fullspäckat program och många intressanta föredrag. Temat var Välfärden – en osäker resa in i framtiden. Flera tillbakablickar gjordes eftersom det är tio år sedan den första prioriteringskonferensen genomfördes och Prioriteringscentrum bildades.

    Konferensen inleddes av tre föredragshållare som med olika infallsvinklar diskuterade om det finns ett långsiktigt resursproblem i svensk vård och omsorg. Anders Ekholm, analyschef på Socialdepartementet inledde med utdrag ur en större kartläggning.

  • 36.
    Mossberg, Lennart (Editor)
    LM Bild & Bokstav AB, Västra Frölunda.
    Vem ska bestämma? : Om rättvisa prioriteringar i vården: Rapport från den tredje nationella prioriteringskonferensen i Göteborg den 22-23 september 20052005Report (Other academic)
    Abstract [sv]

    440 förhoppningsfulla konferensdeltagare tog plats i aulan ”Runan” på Chalmers Tekniska Högskola på morgonen den 22 september 2005. Sorlet dämpades så småningom när konferencier Fredrik Belfrage tog till orda och sakta vandrade fram mot scenen, småpratande med några av konferensdeltagarna. ”Vilka var de, varför hade de kommit hit, vad hoppades de av de två dagarna i Göteborg?”

    Från scenen riktade Fredrik frågan till PrioriteringsCentrums chef, professor Per Carlsson som svarade:

    – Det är en mycket blandad samling. Här finns hälso- och sjukvårdsanställda av olika kategorier, brukare, forskare, administratörer och politiker. Den samlade kompetensen här är både bred och djup. Därför har jag också stora förhoppningar på konferensen. För det behövs en bred samverkan, det finns ingen enskild aktör som äger frågan.

    – Vi kan konstatera att intresset för prioriteringsfrågorna växer hela tiden. Vi har 440 deltagare och har tyvärr tvingats tacka nej till omkring 150. Det visar att frågan är het, trots att den inte märks mycket i media,” sa Per Carlsson.

    – ”Vem ska bestämma” är temat för konferensen. Tror du att vi kommer att ha ett svar på den frågan i morgon kväll? undrade Fredrik Belfrage.

    – Nja, frågan borde nog omformuleras till ”vilka ska bestämma” menade Per. För det är ofrånkomligt att många beslutsfattare deltar: politiker, profession, patienter, allmänhet. Men hur väl vi lyckas besvara frågan beror inte på arrangemanget, det beror på alla som kommit hit. Och det innebär att jag har gott hopp om att vi kommer att ta rejäla kliv framåt under de här två dagarna.

  • 37.
    Hässel, Brita (Editor)
    Hässel & Palm, Västra Frölunda .
    West, Emma (Editor)
    Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Medicine and Health Sciences.
    Ansvar för prioriteringar i ett nytt hälso- och sjukvårdslandskap: Dokumentation från konferensen Sjunde nationella prioriteringskonferensen, Gävle 21-22 oktober 20132013Report (Other academic)
    Abstract [sv]

    Temat för den sjunde upplagan av Nationella prioriteringskonferensen var Ansvar för prioriteringar i ett nytt hälso- och sjukvårdslandskap. Under två fullspäckade oktoberdagar möttes drygt 300 deltagare i Gävle för att lyssna till erfarenheter och insikter om prioriteringar inom hälso- och sjukvården, få nya idéer och själva bidra med tankar och kunskap om ämnet. Under konferensens två dagar gjordes både in- och utblickar, det reflekterades kring genomförda insatser, kring framtiden och nästa steg inom området. Inblick i några föredrag ges i denna textsamling. Vi hoppas att dokumentationen ger dig som besökte konferensen en chans till återspegling och för dig som inte hade möjlighet att delta denna gång, ett smakprov av årets konferens.

  • 38.
    Mossberg, Lennart (Editor)
    LM Bild & Bokstav AB, Västra Frölunda.
    Prioritering i praktiken: Rapport från den andra nationella prioriteringskonferensen, Umeå den 16-17 juni 20032003Report (Other academic)
    Abstract [sv]

    – Vår förmåga att lära av varandra avgör hur vi kommer att lyckas. Därför hoppas jag mycket på den här andra nationella prioriteringskonferensen med mottot ”Hur går vi från ord till handling?”

    Med de orden hälsade Harriet Hedlund, ordförande i folkhälsonämnden i Västerbottens läns landsting, konferensdeltagarna välkomna.

    – Vårdbehoven ökar snabbt, men det gör inte resurserna, konstaterade hon. Nu måste vi också bli överens om hur vi praktiskt löser detta dilemma. Vi ska enas om vilka verktyg vi behöver, hur vi delar upp arbetsuppgifterna rationellt och vi kommer att få ta del av internationella erfarenheter.

    Några fakta om värdstaden Umeå gav Eva Andersson från Kommunförbundet Västerbotten, bland annat att Umeå har cirka 100.000 invånare.

    – Men vi skulle behöva öka till 150.000 till år 2050 för att få tillräcklig skattekraft.

    – Bland alla dem som vill bo i Umeå finns också människor med stort  vårdbehov och antalet 85 år och äldre ökar. Hemtjänst, äldreboende och  förebyggande hälsoarbete prioriteras.

  • 39.
    Mossberg, Lennart (Editor)
    LM Bild & Bokstav AB, Västra Frölunda.
    Perspektiv på prioritering: Dokumentation från en nationell konferens om principer och arbetsformer för öppen prioritering inom vård och omsorg i Linköping den 1-2 oktober 20012001Report (Other academic)
    Abstract [sv]

    I sitt hälsningsanförande uttryckte Per Carlsson att konferensen skulle ge en allsidig belysning av prioriteringsfrågorna inom vård och omsorg.

    Han påminde om att skälen för öppna prioriteringar är goda: värna människors lika värde, värna svaga grupper, värna ”den okända patienten”, värna de patienter som har de största vårdbehoven samt värna god hushållning.

    Han konstaterade att prioritering är ett ”svårsålt” begrepp, dvs ytterst få känner någon spontan entusiasm inför uppgiften att behöva prioritera. Enda sättet att komma fram är därför att göra alla aktörer, patienter, allmänhet, politiker, vårdpersonal, media, medvetna om argumenten för öppna prioriteringar.

    Per Carlsson såg fram emot en konferens som han önskade skulle besvara följande frågor:

    • Vad menas med öppna prioriteringar?
    • Är det önskvärt med öppna prioriteringar?
    • Varför händer så lite i praktiken?
    • Vilka hinder finns?
    • Om det inte är önskvärt med öppna prioriteringar, vilka är då skälen?
  • 40.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20052005Report (Other academic)
  • 41.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20042004Report (Other academic)
  • 42.
    Carlsson, Per (Editor)
    Linköping University, Department of Medical and Health Sciences, Health Technology Assessment and Health Economics. Linköping University, Faculty of Health Sciences.
    Nationellt kunskapscentrum för prioritering inom vård och omsorg: Verksamheten 20032003Report (Other academic)
  • 43.
    Pettersson, Olivia
    et al.
    Linköping University, Department of Medical and Health Sciences.
    Wennfalk, Martina
    Linköping University, Department of Medical and Health Sciences.
    Patient education and adherence to tuberculosis treatment: - Indonesian nurses share their experiences2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    Aim

    The aim of this qualitative study was to explore Indonesian nurses’ experiences of patient education and patients’ adherence to TB treatment.

    Background

    Tuberculosis (TB) is an infectious disease that 9.6 million people in the world suffer from. Indonesia is one of the world’s 22 high-burden countries with over 320.000 cases of TB in 2014. The UN’s (United Nation) goal is to have ended the TB epidemics by the year 2030. Nurses play a central role in accomplishing adherence to treatment and prevention of TB.

    Method

    To fulfil the aim a qualitative method using semi-structured interviews was used. The interviews were recorded and transcribed. The transcribed data was analysed by using a qualitative content analysis with a manifest approach.

    Findings

    The findings, based on the result of nine interviews, showed four themes: “Strategies for patient education”, “Factors affecting patient education and adherence to treatment”, ”Outcomes of patient education” and ”Feelings and opinions about patient education”.

    Conclusion

    This study showed that the nurses use different strategies when practicing patient education. It was also shown that the nurses are well aware about patient-related factors and how they affect patient education and adherence to TB treatment.

    Keywords

    Tuberculosis, nursing care, patient education, adherence 

  • 44.
    Neggers, Sebastian J C M M
    et al.
    Department of Endocrinology Erasmus Medical Center, Rotterdam, Netherlands et al .
    Pronin, Vyacheslav
    1Department of Endocrinology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
    Balcere, Inga
    Department of Endocrinology, Pauls Stradins Clinical University Hospital, Riga, Latvia.
    Lee, Moon-Kyu
    Division of Endocrinology and Metabolism, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea.
    Rozhinskaya, Liudmila
    Department of Neuroendocrinology and Bone Diseases, National Endocrinology Research Centre, Moscow, Russian Federation.
    Bronstein, Marcello D
    Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.
    Gadelha, Mônica R
    Endocrine Section, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Maisonobe, Pascal
    Boulogne-Billancourt, Ipsen, Boulogne-Billancourt, France.
    Sert, Caroline
    Boulogne-Billancourt, Ipsen, Boulogne-Billancourt, France.
    van der Lely, Aart Jan
    Department of Endocrinology, Erasmus Medical Center, Rotterdam, Netherlands.
    Lanreotide Autogel 120 mg at extended dosing intervals in patients with acromegaly biochemically controlled with octreotide LAR: the LEAD study2015In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 173, no 3Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To evaluate extended dosing intervals (EDIs) with lanreotide Autogel 120 mg in patients with acromegaly previously biochemically controlled with octreotide LAR 10 or 20 mg.

    DESIGN AND METHODS: Patients with acromegaly had received octreotide LAR 10 or 20 mg/4 weeks for ≥ 6 months and had normal IGF1 levels. Lanreotide Autogel 120 mg was administered every 6 weeks for 24 weeks (phase 1); depending on week-24 IGF1 levels, treatment was then administered every 4, 6 or 8 weeks for a further 24 weeks (phase 2). Hormone levels, patient-reported outcomes and adverse events were assessed.

    PRIMARY ENDPOINT: proportion of patients on 6- or 8-week EDIs with normal IGF1 levels at week 48 (study end).

    RESULTS: 107/124 patients completed the study (15 withdrew from phase 1 and two from phase 2). Of 124 patients enrolled, 77.4% were allocated to 6- or 8-week EDIs in phase 2 and 75.8% (95% CI: 68.3-83.3) had normal IGF1 levels at week 48 with the EDI (primary analysis). A total of 88.7% (83.1-94.3) had normal IGF1 levels after 24 weeks with 6-weekly dosing. GH levels were ≤ 2.5 μg/l in > 90% of patients after 24 and 48 weeks. Patient preferences for lanreotide Autogel 120 mg every 4, 6 or 8 weeks over octreotide LAR every 4 weeks were high.

    CONCLUSIONS: Patients with acromegaly achieving biochemical control with octreotide LAR 10 or 20 mg/4 weeks are possible candidates for lanreotide Autogel 120 mg EDIs. EDIs are effective and well received among such patients.

  • 45.
    Weiser, Wolfgang
    Linköping University, Department of Behavioural Sciences and Learning, Education, Teaching and Learning. Linköping University, Faculty of Educational Sciences.
    Present Poise In Momentum: Embodied learning of applied aesthetics in our sense of balance – a study about sensorial cultural use of balance2015Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The purpose of this study lies in investigating the embodied learning of applied aesthetics in our sense of balance in the educational space and how it can contribute to change one of a present major public health related problem, the problem of sedentary behaviour in school and society. The investigation is not an effect study, but aims to question our sensorial cultural practice of applied aesthetics, by looking at how we use our ability to balance in the educational space.  Introducing and including elements from the field of art, the aesthetics field of knowledge and life science, the question of acknowledging embodied learning is explored mainly in the sensorial cultural praxis of our ability to balance. Embodied praxis is represented by the Alexander Technique and Elsa Gindler’s concept, with relation to modern neuromechanics. An educational view of knowledge that unilaterally enhances and rewards abstraction as well as theoretical thinking, by validating matrices and merit points, creates unbalance. Treating this unbalance solely with physical exercises enhances the conflict of how to use learning time in school and seems not to lead to a solution. By seeing the educational space as a space of embodied practice the investigation is built around participants’ sense of balance in embodied learning during a school day. The established sensorial cultural practice of how we are using our sense of balance in movement responses is observed during a school day and in a complementary inquiry explored and discussed with the children. Also the time of sitting is measured. The qualitative analysis or reading in this research of embodied learning is done by analysing directions or pointing in poise in momentum for finding inclusive or exclusive corresponsive sensorial tendencies in relation to sensorial cultural practice, including individual, social and regulative aspects. The minor quantitative part in this investigation is looking at the time spent sitting during the school day in the given conditions for defining the pupils’ sedimentary behaviour. The found embodied learning was not noticably acknowledged and not commented by the teacher.  The learning sessions were varying in space, form and in their content. In spite of the attempt of the teacher to create moveability, the children were sitting 54%  or more of the day in school. Inclusive dynamic responsiveness gave ability to balance and promoted embodied learning. Isolated or excluded responsiveness did not noticably engage the sense of balance and did not promote embodied learning. It resulted into pointing or directing downwards and leaning forward, backward or inwards into supportive furniture in accordance with gravitation. The study finds that inclusive responsiveness increases aligned balancing in poise in momentum. In its conclusion the study recognizes the value and effect of physical activity, but argues that moving to be healthy is not effectively changing sedentary behaviour. It argues instead for embodied health sufficient moving on a general sensorial level.  To be able to use our sense of balance as function of intelligence, we still need to increase acknowledgment of our evolutionary inherited skill further.

  • 46.
    Ström, Ola
    Linköping University, Department for Studies of Social Change and Culture. Linköping University, Faculty of Medicine and Health Sciences.
    Utvärdering av kuratorers uppfattning om metoden "Förändrande familjesamtal".2014Independent thesis Advanced level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The aim of the present study was to describe the professional counselors, in Children and Youth Units at Social services in Örebro, opinion on Magnus Ringborgs model Therapeutic family conversations (FFS), and how useful they perceive it to be.

    Seventeen of the Children and Youth Units twenty-five counselors participated in the evaluation. The counselors were interviewed based on an interview form with pre-defined questions and had opportunity to comment. The focus of the evaluation was the various steps of the method and how important the counselors considered them to be. They were then asked general questions about the method´s usefulness and effectiveness.

    Most counselors had a positive approach to FFS. They considered the method to be easy to apply, facilitated family work, gave structure and streamlined the processing work. Some of the counselors did however perceive the method to have limited use in resource poor- and unmotivated families.

  • 47.
    Gheorghiade, Mihai
    et al.
    Northwestern University Feinberg School of Medicine, Chicago, USA.
    Greene, Stephen J
    Duke University Medical Center, Durham, North Carolina, USA.
    Butler, Javed
    Stony Brook University, Stony Brook, New York, USA.
    Filippatos, Gerasimos
    Athens University Hospital Attikon and Kapodistrian University of Athens, Athens, Greece.
    Lam, Carolyn S P
    National Health Center, Singapore and Duke, National University of Singapore, Singapore.
    Maggioni, Aldo P
    Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy.
    Ponikowski, Piotr
    Medical University, Wroclaw, Poland.
    Shah, Sanjiv J
    Northwestern University Feinberg School of Medicine, Chicago, USA.
    Solomon, Scott D
    Brigham and Women's Hospital Boston, Massachusetts, USA.
    Kraigher-Krainer, Elisabeth
    Charite University Medicine Berlin-Campus Virchow Klinikum, Berlin, Germany.
    Samano, Eliana T
    Bayer, Sao Paulo, Brazil.
    Müller, Katharina
    Bauer Pharma, Wuppertal, Germany.
    Roessig, Lothar
    Bauer Pharma, Wuppertal, Germany.
    Burkert, Pieske
    Charité University Medicine Berlin–Campus Virchow Klinikum and German Heart Center Berlin, Germany.
    Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial.2015In: Journal of the American Medical Association (JAMA), ISSN 0098-7484, E-ISSN 1538-3598, Vol. 314, no 21, 2251-2262 p.Article in journal (Refereed)
    Abstract [en]

    IMPORTANCE: Worsening chronic heart failure (HF) is a major public health problem.

    OBJECTIVE: To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic HF and reduced left ventricular ejection fraction (LVEF).

    DESIGN, SETTING, AND PARTICIPANTS: Dose-finding phase 2 study that randomized 456 patients across Europe, North America, and Asia between November 2013 and January 2015, with follow-up ending June 2015. Patients were clinically stable with LVEF less than 45% within 4 weeks of a worsening chronic HF event, defined as worsening signs and symptoms of congestion and elevated natriuretic peptide level requiring hospitalization or outpatient intravenous diuretic.

    INTERVENTIONS: Placebo (n = 92) or 1 of 4 daily target doses of oral vericiguat (1.25 mg [n = 91], 2.5 mg [n = 91], 5 mg [n = 91], 10 mg [n = 91]) for 12 weeks.

    MAIN OUTCOMES AND MEASURES: The primary end point was change from baseline to week 12 in log-transformed level of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The primary analysis specified pooled comparison of the 3 highest-dose vericiguat groups with placebo, and secondary analysis evaluated a dose-response relationship with vericiguat and the primary end point.

    RESULTS: Overall, 351 patients (77.0%) completed treatment with the study drug with valid 12-week NT-proBNP levels and no major protocol deviation and were eligible for primary end point evaluation. In primary analysis, change in log-transformed NT-proBNP levels from baseline to week 12 was not significantly different between the pooled vericiguat group (log-transformed: baseline, 7.969; 12 weeks, 7.567; difference, -0.402; geometric means: baseline, 2890 pg/mL; 12 weeks, 1932 pg/mL) and placebo (log-transformed: baseline, 8.283; 12 weeks, 8.002; difference, -0.280; geometric means: baseline, 3955 pg/mL; 12 weeks, 2988 pg/mL) (difference of means, -0.122; 90% CI, -0.32 to 0.07; ratio of geometric means, 0.885, 90% CI, 0.73-1.08; P = .15). The exploratory secondary analysis suggested a dose-response relationship whereby higher vericiguat doses were associated with greater reductions in NT-proBNP level (P < .02). Rates of any adverse event were 77.2% and 71.4% among the placebo and 10-mg vericiguat groups, respectively.

    CONCLUSIONS AND RELEVANCE: Among patients with worsening chronic HF and reduced LVEF, compared with placebo, vericiguat did not have a statistically significant effect on change in NT-proBNP level at 12 weeks but was well-tolerated. Further clinical trials of vericiguat based on the dose-response relationship in this study are needed to determine the potential role of this drug for patients with worsening chronic HF.

    TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01951625.

  • 48.
    Galiè, Nazzareno
    et al.
    University of Bologna, Italy.
    Barberà, Joan A
    University of Barcelona and Biomedical Research Networking Center on Respiratory Diseases, Madrid, Spain.
    Frost, Adaani E
    Baylor College of Medicine, Houston, USA.
    Ghofrani, Hossein-Ardeschir
    University of Giessen and Marbury Lung Center, Giessen, Germany.
    Hoeper, Marius M
    Hanover Medical School and German Center of Lung Research, Hanover, Germany.
    McLaughlin, Vallerie V
    University of Michigan, USA.
    Peacock, Andrew J
    Regional Heart and Lung Center, Glasgow, Scotland.
    Simonneau, Gérald
    University Paris-Sud, Paris, France.
    Vachiery, Jean-Luc
    Hospital Erasme, Brussels, Belgium.
    Grünig, Ekkehard
    University Hospital Heidelberg, Heidelberg, Germany.
    Oudiz, Ronald J
    UCLA Medical Center, Torrance,USA.
    Vonk-Noordegraaf, Anton
    University Medical Center, Amsterdam, Netherlands.
    White, R James
    University of Rochester, NY, USA.
    Blair, Christiana
    Gilead Sciences, Foster City.
    Gillies, Hunter
    Gilead Sciences, Foster City.
    Miller, Karen L
    Gilead Sciences, Foster City.
    Harris, Julia H N
    GlaxoSmith Kline, Uxbridge, UK.
    Langley, Jonathan
    GlaxoSmith Kline, Uxbridge, UK.
    Rubin, Lewis J
    University of California at San Diego, USA.
    Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension2015In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 373, no 9Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with pulmonary arterial hypertension are scarce.

    METHODS: In this event-driven, double-blind study, we randomly assigned, in a 2:1:1 ratio, participants with World Health Organization functional class II or III symptoms of pulmonary arterial hypertension who had not previously received treatment to receive initial combination therapy with 10 mg of ambrisentan plus 40 mg of tadalafil (combination-therapy group), 10 mg of ambrisentan plus placebo (ambrisentan-monotherapy group), or 40 mg of tadalafil plus placebo (tadalafil-monotherapy group), all administered once daily. The primary end point in a time-to-event analysis was the first event of clinical failure, which was defined as the first occurrence of a composite of death, hospitalization for worsening pulmonary arterial hypertension, disease progression, or unsatisfactory long-term clinical response.

    RESULTS: The primary analysis included 500 participants; 253 were assigned to the combination-therapy group, 126 to the ambrisentan-monotherapy group, and 121 to the tadalafil-monotherapy group. A primary end-point event occurred in 18%, 34%, and 28% of the participants in these groups, respectively, and in 31% of the pooled-monotherapy group (the two monotherapy groups combined). The hazard ratio for the primary end point in the combination-therapy group versus the pooled-monotherapy group was 0.50 (95% confidence interval [CI], 0.35 to 0.72; P<0.001). At week 24, the combination-therapy group had greater reductions from baseline in N-terminal pro-brain natriuretic peptide levels than did the pooled-monotherapy group (mean change, -67.2% vs. -50.4%; P<0.001), as well as a higher percentage of patients with a satisfactory clinical response (39% vs. 29%; odds ratio, 1.56 [95% CI, 1.05 to 2.32]; P=0.03) and a greater improvement in the 6-minute walk distance (median change from baseline, 48.98 m vs. 23.80 m; P<0.001). The adverse events that occurred more frequently in the combination-therapy group than in either monotherapy group included peripheral edema, headache, nasal congestion, and anemia.

    CONCLUSIONS: Among participants with pulmonary arterial hypertension who had not received previous treatment, initial combination therapy with ambrisentan and tadalafil resulted in a significantly lower risk of clinical-failure events than the risk with ambrisentan or tadalafil monotherapy. (Funded by Gilead Sciences and GlaxoSmithKline; AMBITION ClinicalTrials.gov number, NCT01178073.).

  • 49.
    Harnesk, Gustav
    et al.
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Management and Engineering.
    Hellström, John
    Linköping University, Faculty of Arts and Sciences. Linköping University, Department of Management and Engineering.
    Effekter av e-tjänster inom den offentliga vården: En kvalitativ fallstudie om hur e-tjänster kan påverka en offentlig vårdorganisations verksamhet och dess medarbetare2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    E-services are becoming increasingly prevalent in various contexts. Organizations in the public sector have also embraced this trend and today provide e-services with different purposes, e.g. various e-health services. Although there are advantages of e-services compared to traditional channels, they are not free of problems; a public organization must, among other things, provide an availability that private organizations may not need. This in turn means that the business needs to adapt its internal IT systems to handle incoming cases, which affects both the organization’s business and its employees. As today’s demands exceeds the resources, and that the population in Sweden is growing older, demands increase on the health care’s business. Citizens have to take greater responsibility for their own healthcare, which involves changes in working methods through effective e-services. Therefore, we examined the consequences this has within the business, as well as how the use of e-services affects the employees’ working routines and administrative work.

    The study aims to identify and analyze consequences, opportunities and obstacles with e-health and e-services within a public health care organization. In this way, we see that the study may help with possible explanations to the challenges that arise from the use of e-services in the public health care. The intention is also to identify and describe possible gaps between expected effects of strategies and the outcome in the operational business, which we see can contribute to greater understanding of the differences and how they might be handled. The study is based on a qualitative case study on Region Östergötland, where we have collected empirical data through interviews. The interviews have then been interpreted and analyzed to provide an illustration of how the organization strategically works with e-services in the public healthcare and how this is manifested in the business.

    The study results and conclusions show that there are both positive and less desirable effects of e-services within the operational level of the business. The same also applies to certain strategic decisions, particularly the decision to make patient records available through the e-service My health care contacts. We consider that an important contribution of the study is to highlight the needs from the operational health care business, as well as the importance of taking these into account in the development of e-health and e-service related strategies. We consider that another contribution of the study is the need to reflect on the business implications that may arise as a result of e-services.

  • 50.
    Mounagurusamy, Purani
    Linköping University, Department of Computer and Information Science, Database and information techniques.
    Parsing AQL Queries into SQL Queries using ANTLR2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    An Electronic Health Record is a collection of each patient’s health information which is stored electronically or in digital format. openEHR is an open standard specification for electronic health record data. openEHR has a method for querying a set of clinical data using the Archetype Query Language (AQL). 

    The EHR data is in XML format and this format is a tree like structure. Since XML databases were considerably slower, AQL needs to be translated to another query language. Researchers have already investigated translating AQL to XQuery and tested the performance. Since the performance was not satisfactory, we now investigate translating AQL to SQL.

    AQL queries are translated to SQL queries using the ANTLR tool. The translation is implemented in Java language. The AQL queries which are translated into SQL queries are also tested in this thesis work. Finally, the result is to get the corresponding SQL query for any given AQL query.

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