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  • 1.
    Zhang, Xuanjun
    et al.
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Xie, Yi
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Zhao, Qingrui
    Structure Research Laboratory and Department of Chemistry, University of Science and Technology of China.
    Tian, Yupeng
    Department of Chemistry, Anhui University, China.
    1-D coordination polymer template approach to CdS and HgS aligned-nanowire bundles2003In: New Journal of Chemistry, ISSN 1144-0546, E-ISSN 1369-9261, Vol. 27, no 5, 827-830 p.Article in journal (Refereed)
    Abstract [en]

    A 1D inorganic coordination polymer template route was firstly developed to synthesize metal sulfide aligned-nanowire bundles. Based on this strategy, CdS and HgS aligned-nanowire bundles with high yields were successfully prepared in a water system at room temperature using KCd(NCS)3 as a soft template. The results revealed that the morphologies of the MS (M=Cd, Hg) aligned-nanowire bundles were uniform with lengths of several microns and the diameters of each single wire were ca. 10–30 nm and 60–80 nm for CdS and HgS, respectively.

  • 2.
    Bergh, Torsten
    et al.
    Swedish Transport Adm, Sweden; Movea Trafikkonsult, Sweden.
    Remgard, Mats
    Swedish Transport Adm, Sweden.
    Carlsson, Arne
    Swedish National Rd and Transport Research Institute, Linköping, Sweden.
    Olstam, Johan
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering. Swedish National Road and Transport Research Institute, Linköping, Sweden.
    Strömgren, Per
    Movea Trafikkonsult, Sweden.
    2+1-roads Recent Swedish Capacity and Level-of-Service Experience2016In: INTERNATIONAL SYMPOSIUM ON ENHANCING HIGHWAY PERFORMANCE (ISEHP), (7TH INTERNATIONAL SYMPOSIUM ON HIGHWAY CAPACITY AND QUALITY OF SERVICE, 3RD INTERNATIONAL SYMPOSIUM ON FREEWAY AND TOLLWAY OPERATIONS), ELSEVIER SCIENCE BV , 2016, Vol. 15, 331-345 p.Conference paper (Refereed)
    Abstract [en]

    The first Swedish 2+1 median barrier road was opened in 1998. The concept was to retrofit the standard existing two-lane 13 m paved width cross-section at 90 and 110 kph posted speed limit without widening. This design has one continuous lane in each direction, a middle lane changing direction every one to three kilometres with a median barrier separating the two traffic directions. Today over 2 700 km 2+1 median barrier roads are opened for traffic. AADTs vary from some 3 000 to 20 000 with an average just below 10 000 nowadays normally with 100 kph. The concept has lately been enhanced also to cover the existing 9 m paved width cross-section. The design concept is the same from a drivers viewpoint, one continuous lane in each direction with a middle lane changing direction and a separating median barrier. This is created by introducing a continuous median barrier and adding overtaking lanes within an overtaking strategy. The differences are the existence of 1+1-sections, less overtaking opportunities and a slightly more narrow cross-section. Some 15 projects are opened. The purpose of this paper is to summarize present knowledge on level-of-service issues as they are presented in Swedish design and assessment guidelines and to give an overview of field measurements and theoretical analytical and simulation studies supporting the recommendations.

  • 3.
    Lagerqvist, Bo
    et al.
    Uppsala.
    Husted, Steen
    Århus,Danmark.
    Koontny, Fredrik
    Oslo, Norge.
    Ståhle, Elisabeth
    Uppsala.
    Swahn, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Cardiology. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Wallentin, Lars
    Uppsala.
    5-year outcomes in the FRISC-II randomised trial of an invasive versus a non-invasive strategy in non-ST-elevation acute coronary syndrome: a follow-up study2006In: The Lancet, ISSN 0140-6736, Vol. 368, no 9540, 998-1004 p.Article in journal (Refereed)
    Abstract [en]

    Background: The FRISC-II invasive trial compared an early invasive with a non-invasive strategy in terms of death and myocardial infarction in non-ST-elevation acute coronary syndrome. We present 5-year follow-up results, overall and in subgroups based on recommended risk stratification criteria. Methods: In the FRISC-II trial, 2457 patients with non-ST-elevation acute coronary syndrome were randomised to early invasive strategy (coronary angiography and, if appropriate, revascularisation, within 7 days from admission) or non-invasive primarily medical strategy. Risk stratification was done on the basis of risk indicators at randomisation: age older than 65 years, male sex, diabetes mellitus, previous myocardial infarction, ST-segment depression, raised troponin concentration (>0·03 μg/L), and raised C-reactive protein or interleukin 6. Information on events after 24 months was taken from national registries. Analyses were done on an intention-to-treat basis. Findings: At 5 years the groups differed in terms of the primary composite endpoint of death, myocardial infarction, or both (invasive 217, 19·9 %, noninvasive 270, 24·5 %, risk ratio 0·81, 95% CI 0·69-0·95, p=0·009). 5-year mortality was 117 (9·7%) in the invasive group compared with 124 (10·1%) in the noninvasive group (0·95, 0·75 -1·21, p=0·693). Rates of myocardial infarction were 141 (12·9 %) in the invasive and 195 (17.7%) in the non-invasive group (0·73, 0·60-0·89, p=0·002). The benefit of the invasive strategy was confined to male patients, non-smokers, and patients with two or more risk indicators. Interpretation: The 5-year outcome of this trial indicates sustained benefit of an early invasive strategy in patients with non-ST-elevation acute coronary syndrome at moderate to high risk. © 2006 Elsevier Ltd. All rights reserved.

  • 4.
    Johansson, Ted
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Bengtsson, Olof
    Lotfi, Sara
    Uppsala University, Sweden.
    Vestling, Lars
    Uppsala University, Sweden.
    Norström, Hans
    Uppsala University, Sweden.
    Olsson, Jörgen
    Uppsala University, Sweden.
    Nyström, Christian
    A +32.8 dBm LDMOS power amplifier for WLAN in 65 nm CMOS technology2013Conference paper (Refereed)
    Abstract [en]

    Postlingually acquired hearing impairment (HI) is associated with changes in the representation of sound in semantic long-term memory. An indication of this is the lower performance on visual rhyme judgment tasks in conditions where phonological and orthographic cues mismatch, requiring high reliance on phonological representations. In this study, event-related potentials (ERPs) were used for the first time to investigate the neural correlates of phonological processing in visual rhyme judgments in participants with acquired HI and normal hearing (NH). Rhyme task word pairs rhymed or not and had matching or mismatching orthography. In addition, the inter-stimulus interval (ISI) was manipulated to be either long (800 ms) or short (50 ms). Long ISIs allow for engagement of explicit, top-down processes, while short ISIs limit the involvement of such mechanisms. We hypothesized lower behavioral performance and N400 and N2 deviations in HI in the mismatching rhyme judgment conditions, particularly in short ISI. However, the results showed a different pattern. As expected, behavioral performance in the mismatch conditions was lower in HI than in NH in short ISI, but ERPs did not differ across groups. In contrast, HI performed on a par with NH in long ISI. Further, HI, but not NH, showed an amplified N2-like response in the non-rhyming, orthographically mismatching condition in long ISI. This was also the rhyme condition in which participants in both groups benefited the most from the possibility to engage top-down processes afforded with the longer ISI. Taken together, these results indicate an early ERP signature of HI in this challenging phonological task, likely reflecting use of a compensatory strategy. This strategy is suggested to involve increased reliance on explicit mechanisms such as articulatory recoding and grapheme-to-phoneme conversion.

  • 5.
    Garrido Gálvez, Mario
    et al.
    Linköping University, Department of Electrical Engineering, Computer Engineering. Linköping University, Faculty of Science & Engineering.
    Angel Sanchez, Miguel
    University of Politecn Madrid, Spain.
    Luisa Lopez-Vallejo, Maria
    University of Politecn Madrid, Spain.
    Grajal, Jesus
    University of Politecn Madrid, Spain.
    A 4096-Point Radix-4 Memory-Based FFT Using DSP Slices2017In: IEEE Transactions on Very Large Scale Integration (vlsi) Systems, ISSN 1063-8210, E-ISSN 1557-9999, Vol. 25, no 1, 375-379 p.Article in journal (Refereed)
    Abstract [en]

    This brief presents a novel 4096-point radix-4 memory-based fast Fourier transform (FFT). The proposed architecture follows a conflict-free strategy that only requires a total memory of size N and a few additional multiplexers. The control is also simple, as it is generated directly from the bits of a counter. Apart from the low complexity, the FFT has been implemented on a Virtex-5 field programmable gate array (FPGA) using DSP slices. The goal has been to reduce the use of distributed logic, which is scarce in the target FPGA. With this purpose, most of the hardware has been implemented in DSP48E. As a result, the proposed FPGA is efficient in terms of hardware resources, as is shown by the experimental results.

  • 6.
    Zhang, Dai
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Bhide, Ameya
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    A 53-nW 9.12-ENOB 1-kS/s SAR ADC in 0.13-um CMOS for medical implant devices2011In: Proceedings of the IEEE European Solid-State Circuits Conference (ESSCIRC), Helsinki, Finland: IEEE Solid-State Circuits Society, 2011, 467-470 p.Conference paper (Refereed)
    Abstract [en]

    This paper describes an ultra-low-power SAR ADC in 0.13-um CMOS technology for medical implant devices. It utilizes an ultra-low-power design strategy, imposing maximum simplicity in ADC architecture, low transistor count, low-voltage low-leakage circuit techniques, and matched capacitive DAC with a switching scheme which results in full-range sampling without switch bootstrapping and extra reset voltage. Furthermore, a dual-supply scheme allows the SAR logic to operate at 400mV. The ADC has been fabricated in 0.13-um CMOS. In 1.0-V single-supply mode, the ADC consumes 65nW at a sampling rate of 1kS/s, while in dual-supply mode (1.0V for analog and 0.4V for digital) it consumes 53nW (18% reduction) and achieves the same ENOB of 9.12. 24% of the 53-nW total power is due to leakage. To the authors' best knowledge, this is the lowest reported power consumption of a 10-bit ADC for such sampling rates.

  • 7.
    Zhang, Dai
    et al.
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Bhide, Ameya
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    Alvandpour, Atila
    Linköping University, Department of Electrical Engineering, Electronic Devices. Linköping University, The Institute of Technology.
    A 53-nW 9.1-ENOB 1-kS/s SAR ADC in 0.13-μm CMOS for Medical Implant Devices2012In: IEEE Journal of Solid-State Circuits, ISSN 0018-9200, Vol. 47, no 7, 1585-1593 p.Article in journal (Refereed)
    Abstract [en]

    This paper describes an ultra-low power SAR ADC for medical implant devices. To achieve the nano-watt range power consumption, an ultra-low power design strategy has been utilized, imposing maximum simplicity on the ADC architecture, low transistor count and matched capacitive DAC with a switching scheme which results in full-range sampling without switch boot-strapping and extra reset voltage. Furthermore, a dual-supply voltage scheme allows the SAR logic to operate at 0.4 V, reducing the overall power consumption of the ADC by 15% without any loss in performance. The ADC was fabricated in 0.13-mu m CMOS. In dual-supply mode (1.0 V for analog and 0.4 V for digital), the ADC consumes 53 nW at a sampling rate of 1 kS/s and achieves the ENOB of 9.1 bits. The leakage power constitutes 25% of the 53-nW total power.

  • 8.
    Zhang, Yingfeng
    et al.
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China.
    Ren, Shan
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China; Department of Mechanical Engineering, Honghe University, Yunnan, PR China.
    Liu, Yang
    Linköping University, Department of Management and Engineering, Environmental Technology and Management. Linköping University, Faculty of Science & Engineering. Department of Production, University of Vaasa, Vaasa, Finland.
    Si, Shubin
    Key Laboratory of Contemporary Design and Integrated Manufacturing Technology, Ministry of Education, Northwestern Polytechnical University, Shaanxi, PR China.
    A big data analytics architecture for cleaner manufacturing and maintenance processes of complex products2017In: Journal of Cleaner Production, ISSN 0959-6526, E-ISSN 1879-1786, Vol. 142, no 2, 626-641 p.Article in journal (Refereed)
    Abstract [en]

    Cleaner production (CP) is considered as one of the most important means for manufacturing enterprises to achieve sustainable production and improve their sustainable competitive advantage. However, implementation of the CP strategy was facing barriers, such as the lack of complete data and valuable knowledge that can be employed to provide better support on decision-making of coordination and optimization on the product lifecycle management (PLM) and the whole CP process. Fortunately, with the wide use of smart sensing devices in PLM, a large amount of real-time and multi-source lifecycle big data can now be collected. To make better PLM and CP decisions based on these data, in this paper, an overall architecture of big data-based analytics for product lifecycle (BDA-PL) was proposed. It integrated big data analytics and service-driven patterns that helped to overcome the above-mentioned barriers. Under the architecture, the availability and accessibility of data and knowledge related to the product were achieved. Focusing on manufacturing and maintenance process of the product lifecycle, and the key technologies were developed to implement the big data analytics. The presented architecture was demonstrated by an application scenario, and some observations and findings were discussed in details. The results showed that the proposed architecture benefited customers, manufacturers, environment and even all stages of PLM, and effectively promoted the implementation of CP. In addition, the managerial implications of the proposed architecture for four departments were analyzed and discussed. The new CP strategy provided a theoretical and practical basis for the sustainable development of manufacturing enterprises.

  • 9.
    Edström, Kristina
    et al.
    School of Education and Communication in Engineering Science, KTH Royal Institute of Technology, Stockholm, Sweden.
    Kolmos, Anette
    Department of Development and Planning, Aalborg University, Aalborg, Denmark.
    Malmi, Lauri
    Department of Computer Science, Aalto University, Helsinki, Finland.
    Bernhard, Jonte
    Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
    Andersson, Pernille
    LearningLab DTU, Technical University of Denmark, Kgs. Lyngby, Denmark.
    A bottom-up strategy for establishment of EER in three Nordic countries: The role of networks2016In: European Journal of Engineering Education, ISSN 0304-3797, E-ISSN 1469-5898Article in journal (Refereed)
    Abstract [en]

    This paper investigates the emergence of an engineering education research (EER) community in three Nordic countries: Denmark, Finland and Sweden. First, an overview of the current state of Nordic EER authorship is produced through statistics on international publication. Then, the history of EER and its precursor activities is described in three national narratives. These national storylines are tied together in a description of recent networking activities, aiming to strengthen the EER communities on the Nordic level. Taking these three perspectives together, and drawing on concepts from community of practice theory, network theory and learning network theory, we discuss factors behind the differences in the countries, and draw some conclusions about implications for networking activities in a heterogeneous community. Further, we discuss the role of networks for affording a joint identity.

  • 10.
    Sundin, Elisabeth
    et al.
    Linköping University, HELIX Vinn Excellence Centre. Linköping University, Department of Management and Engineering, Business Administration. Linköping University, Faculty of Arts and Sciences.
    Hedlund, Gun
    A characteristic strategy of the period2012In: Gender Mainstreaming as a Sustainable Process / [ed] Lindholm, Kristina.Lindholm, Kristina.Sjöberg, Karin.Svensson, Lennart, Studentlitteratur, 2012, 249-270 p.Chapter in book (Other academic)
  • 11.
    Sandberg, Erik
    et al.
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    Abrahamsson, Mats
    Linköping University, Department of Management and Engineering, Logistics Management. Linköping University, The Institute of Technology.
    A Classification of Different Strategic Roles of Logistics2012Conference paper (Other academic)
  • 12.
    Johansson, Linda
    et al.
    Linköping University, Department of Science and Technology.
    Kruse, Björn
    Linköping University, Department of Science and Technology, Digital Media. Linköping University, The Institute of Technology.
    A Colour Separation Strategy for Reproduction of Printed Dynamic Images on Paper Substrate2005In: iarigai Research Conference,2005, Zagreb: Iarigai , 2005, 191- p.Conference paper (Refereed)
  • 13.
    Xie, Yi
    et al.
    Wuhan Engineering Consulting Bureau, Wuhan, China.
    Takala, Josu
    Faculty of TechnologyUniversity of Vaasa, Vaasa, Finland.
    Liu, Yang
    Faculty of TechnologyUniversity of Vaasa, Vaasa, Finland.
    Chen, Yong
    Old Dominion University, Norfolk, USA.
    A combinatorial optimization model for enterprise patent transfer2015In: Journal of Special Topics in Information Technology and Management, ISSN 1385-951X, E-ISSN 1573-7667, Vol. 16, no 4, 327-337 p.Article in journal (Refereed)
    Abstract [en]

    Enterprises need patent transfer strategies to improve their technology management. This paper proposes a combinatorial optimization model that is based on intelligent computing to support enterprises’ decision making in developing patent transfer strategy. The model adopts the Black–Scholes Option Pricing Model and Arbitrage Pricing Theory to estimate a patent’s value. Based on the estimation, a hybrid genetic algorithm is applied that combines genetic algorithms and greedy strategy for the optimization purpose. Encode repairing and a single-point crossover are applied as well. To validate this proposed model, a case study is conducted. The results indicate that the proposed model is effective for achieving optimal solutions. The combinatorial optimization model can help enterprise promote their benefits from patent sale and support the decision making process when enterprises develop patent transfer strategies.

  • 14.
    Hildebrand, Cisilia
    et al.
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    Hörtin, Stina
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, The Institute of Technology.
    A comparative study between Emme and Visum with respect to public transport assignment2014Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    Macroscopic traffic simulations are widely used in the world in order to provide assistance in the traffic infrastructure development as well as for the strategic traffic planning. When studying a large traffic network macroscopic traffic simulation can be used to model current and future traffic situations. The two most common software used for traffic simulation in Sweden today are Emme and Visum, developed by INRO respective PTV.

    The aim of the thesis is to perform a comparison between the software Emme and Visum with respect to the assignment of public transport, in other words how passengers choose their routes on the existing public transport lines. However, in order to make a complete software comparison the run-time, analysis capabilities, multi-modality, capacity to model various behavioural phenomena like crowding, fares etc. this will not be done in this comparison. It is of interest to study the differences between the two software algorithms and why they might occur because the Swedish Transport Administration uses Emme and the Traffic Administration in Stockholm uses Visum when planning public transport. The comparison will include the resulting volumes on transit lines, travel times, flow through specific nodes, number of boarding, auxiliary volumes and number of transits. The goal of this work is to answer the following objective: What are the differences with modelling a public transport network in Emme and in Visum, based on that the passengers only have information about the travel times and the line frequency, and why does the differences occur?

    In order to evaluate how the algorithms work in a larger network, Nacka municipality (in Stockholm) and the new metro route between Nacka Forum and Kungsträdgården have been used. The motivation for choosing this area and case is due to that it is interesting to see what differences could occur between the programs when there is a major change in the traffic network.

    The network of Nacka, and parts of Stockholm City, has been developed from an existing road network of Sweden and then restricted by "cutting out" the area of interest and then removing all public transportation lines outside the selected area. The OD-matrix was also limited and in order not to loose the correct flow of travellers portal zones was used to collect and retain volumes.

    To find out why the differences occur the headway-based algorithms in each software were studied carefully. An example of a small and simple network (consisting of only a start and end node) has been used to demonstrate and show how the algorithms work and why volumes split differently on the existing transit lines in Emme and Visum. The limited network of Nacka shows how the different software may produce different results in a larger public transport network.

    The results show that there are differences between the program algorithms but the significance varies depending on which output is being studied and the size of the network. The Visum algorithm results in more total boardings, i.e. more passengers have an optimal strategy including a transit. The algorithms are very similar in both software programs, since they include more or less parts of the optimal strategy. The parameters used are taken more or less into consideration in Emme and Visum. For example Visum will first of all focus on the shortest total travel time and then consider the other lines with respect to the maximum waiting time. Emme however, first focuses on the shortest travel time and then considers the total travel time for other lines with half the waiting time instead of the maximum wait time. This results in that less transit lines will be attractive in Emme compared to Visum. The thesis concludes that varying the parameters for public transport in each software algorithm one can obtain similar results, which implies that it is most important to choose the best parameter values and not to choose the "best" software when simulating a traffic network.

  • 15.
    Schon, Thomas
    et al.
    Kalmar County Hospital.
    Labbe Sandelin, Lisa
    Kalmar County Hospital.
    Bonnedahl, Jonas
    Kalmar County Hospital.
    Hedeback, Fredrika
    Kalmar County Hospital.
    Wistedt, Annika
    Kalmar County Hospital.
    Brudin, Lars
    Linköping University, Department of Medical and Health Sciences, Clinical Physiology. Linköping University, Faculty of Health Sciences.
    Jarnheimer, Per-Ake
    Kalmar County Hospital.
    A comparative study of three methods to evaluate an intervention to improve empirical antibiotic therapy for acute bacterial infections in hospitalized patients2011In: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, ISSN 0036-5548, Vol. 43, no 4, 251-257 p.Article in journal (Refereed)
    Abstract [en]

    Background: In order to limit the use of broad-spectrum antibiotics, standardized empirical therapy against acute bacterial infections has been advocated. Methods: Guidelines for acute bacterial infections recommending increased usage of benzylpenicillin and restricted use of fluoroquinolones and cephalosporins have been implemented in Kalmar County, Sweden. We evaluated this strategy by recording therapy in patients with bacteraemia, antibiotic requisition, and point prevalence surveys prior to this intervention and at 6 and 12 months after. Results: Comparing the methods simultaneously, there was good agreement between them and an overall significant change in antibiotic usage. There was a significant shift from cefuroxime to cefotaxime and a borderline significant increase in the use of benzylpenicillin (p == 0.057). Based on the defined daily dose (DDD), a highly significant decrease in total cefotaxime and cefuroxime usage was observed that was not detected when applying the prescribed daily dose (PDD), which is adapted to local treatment practices. No change was found in mortality in Staphylococcus aureus bacteraemia or the incidence of Clostridium difficile infection. Conclusions: We conclude that the implementation of the new guidelines has resulted in a significant change in antibiotic usage, which could be conveniently monitored by antibiotic requisition if PDD is used in addition to DDD.

  • 16.
    Vallin, Olesya
    Linköping University, Department of Religion and Culture.
    A Complementary Developmental View on Morally Arbitrary Contingencies in Rawls’s Theory of Justice2007Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The paper explores theoretical shortcomings in the egalitarian theory by John Rawls and provides a complementary view on the problem of morally arbitrary contingencies. The conception of natural lottery, which Rawls presents to signify the starting range of morally arbitrary inequalities, falls short in philosophical grounding. According to critics, the notion of natural lottery appeals to the philosophical conception of moral luck which undermines ascription of moral responsibility. Since moral responsibility is a basic prerequisite for egalitarian justice, the appeal to morally arbitrary contingencies of the natural lottery may be self-defeating for the theory.

    Criticizing Rawls’s approach to morally arbitrary contingencies Susan Hurley investigates philosophical groundings for judgment of moral responsibility. Philosophical inquiries into moral luck differentiate four categories of luck and expose the difficulties of ascription of moral responsibility for it. The conception of moral luck implies epistemological shortcomings in the rational judgment of moral responsibility. Hurley claims that ascription of moral responsibility requires another logical strategy.

    The critical discussion by Norman Daniels refers to another egalitarian theory by Ronald Dworkin which suggests ascription of moral responsibility on a gradual scale. The theory divides the naturally contingent recourses into categories of brute luck and option luck. This strategy stratifies normative standards of responsibility by the criteria of individual choice and circumstances.

    Considering the strategy of gradual ascription of responsibility, I suggest to apply a moral developmental perspective as an additional outlook on the moral responsibility in egalitarian theory. The theory of moral development by Lawrence Kohlberg provides an explanation of a gradual development of moral responsibility through a natural order of developmental stages. It stratifies the moral responsibility into a hierarchical model of measurement and systematizes the order of normative standards.

  • 17.
    Hughes, B. P.
    et al.
    Curtin University, Australia.
    Anund, Anna
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Swedish Rd and Transport Research Institute, S-58195 Linkoping, Sweden.
    Falkmer, Torbjörn
    Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center. Curtin University, Australia; La Trobe University, Australia.
    A comprehensive conceptual framework for road safety strategies2016In: Accident Analysis and Prevention, ISSN 0001-4575, E-ISSN 1879-2057, Vol. 90, 13-28 p.Article in journal (Refereed)
    Abstract [en]

    Road safety strategies (generally called Strategic Highway Safety Plans in the USA) provide essential guidance for actions to improve road safety, but often lack a conceptual framework that is comprehensive, systems theory based, and underpinned by evidence from research and practice. This paper aims to incorporate all components, policy tools by which they are changed, and the general interactions between them. A framework of nine mutually interacting components that contribute to crashes and ten generic policy tools which can be applied to reduce the outcomes of these crashes was developed and used to assess 58 road safety strategies from 22 countries across 15 years. The work identifies the policy tools that are most and least widely applied to components, highlighting the potential for improvements to any individual road safety strategy, and the potential strengths and weaknesses of road safety strategies in general. The framework also provides guidance for the development of new road safety strategies, identifying potential consequences of policy tool based measures with regard to exposure and risk, useful for both mobility and safety objectives. (C) 2016 Elsevier Ltd. All rights reserved.

  • 18.
    Hjalmarson, Emil
    Linköping University, Department of Electrical Engineering, Electronics System. Linköping University, The Institute of Technology.
    A computer-aided approach to design of robust analog circuits2006Doctoral thesis, monograph (Other academic)
    Abstract [en]

    Traditional design methods for analog circuits are based on rules-of-thumbs, experience, and trial-and-error approaches involving the use of circuit simulators. It is an unstructured process, which is time-consuming, error prone, and requires the attention of a skilled analog designer. This situation calls for design methodologies that are more efficient.

    We have developed an efficient approach and corresponding tools that address these issues. A computer-aided design tool for design of large analog circuits with low level of human intervention has been developed. The tool combines efficient performance measure evaluation and optimization methods to determine the device sizes and generate layouts for analog circuits. Large analog circuits with about 200 devices have been designed. The circuits are optimized with respect to, e.g., power consumption, and subject to a large number of performance requirements. All performance measures are automatically derived, which reduces the probability of introducing errors.

    Experimental results indicate that our approach can be used to design robust high-performance analog circuits with improved performance compared to manual approaches. Furthermore, the computer-aided tool decreases both the overall design time and the time required of a skilled designer.

    To accomplish this, an optimization strategy that enables device sizing without an initial design has been developed. Robust circuits are obtained by taking the variations in the manufacturing process into account. Degrading layout effects are also considered using a parasitic feedback technique. To gain insight and allow exploration of the complex relation between performance measures in analog circuits, we have developed techniques for design space exploration.

  • 19.
    Gunnarsson, Fredrik
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Blom, Jonas
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gustafsson, Fredrik
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Concept of Power Control in Cellular Radio Systems1999Report (Other academic)
    Abstract [en]

    Due to the rapid expansion of the cellular radio systems market, and the need for wireless multimedia services, the available resources have to be utilized efficently. A common strategy is to control the transmitter powers of the mobiles and base stations. However, when applying power control to real systems, a number of challenges are prevalent. The performance is limited by time delays, nonlinearities and the availability of measurements and adequate quality measures. In this paper we present a Power Regulator concept, which comprises an Unknown Input Observer, a Quality Mapper and a Power Control Algorithm. The applicability of the concept is exemplified using frequency hopping GSM, and simulations indicate benefits of employing the proposed concept.

  • 20.
    Gunnarsson, Fredrik
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Blom, Jonas
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Gustafsson, Fredrik
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Concept of Power Control in Cellular Radio Systems1999In: Proceedings of the 14th World Congress, 1999Conference paper (Refereed)
    Abstract [en]

    Due to the rapid expansion of the cellular radio systems market, and the need for wireless multimedia services, the available resources have to be utilized efficently. A common strategy is to control the transmitter powers of the mobiles and base stations. However, when applying power control to real systems, a number of challenges are prevalent. The performance is limited by time delays, nonlinearities and the availability of measurements and adequate quality measures. In this paper we present a Power Regulator concept, which comprises an Unknown Input Observer, a Quality Mapper and a Power Control Algorithm. The applicability of the concept is exemplified using frequency hopping GSM, and simulations indicate benefits of employing the proposed concept.

  • 21.
    Fejes, Andreas
    et al.
    Linköping University, Department of Behavioural Sciences and Learning, Education and Adult Learning. Linköping University, Faculty of Educational Sciences.
    Nicoll, Katherine
    University of Stirling.
    A confessing 'science' in education and lifelong learning2013Conference paper (Refereed)
    Abstract [en]

    In this paper we identify resources drawn on from Foucault that are distinctive and pertinent for specific forms of analyses of what is happening in the turn to confessional practices in education and lifelong learning. We identify that confessional practices have come to shape and govern the Western world; they have emerged across the practices of the human sciences and are now intrinsic to our everyday lives and understandings of ourselves. Education and learning have a key position in promulgating confessional practices as a new social norm. They are key as perpetrators of this new kind fashioning of ourselves as human kinds in a particular way.

     

    We describe a regime and apparatus of power of education and lifelong learning which has confession intrinsic to its maintenance and productive force. Confession is described as technology, conduit of power, operating one person in relation to another, and dominating today in the production of specific forms of confessing people.  We call this ‘strategy’. Within this regime, in education and policy circles and more widely, we identify a shift in the talk accompanying and surrounding the emergence of these techniques: whereas before educators and policy makers talked about education, they now talk of learning. Lifelong learning and the learning society, the knowledge economy, society and Knowledge Age are themes that have come to dominate the texts emanating from the cloistered grounds of governmental offices and intra-national agencies. The question remains therefore of where this strategy takes us in terms of its wider social and political effects in western societies.

    The paper identifies and explores other previous educational and lifelong learning research that has considered confessional practices to consider whether or not these find answers to the question of what is happening today'

  • 22.
    Blikstad, Mathias
    et al.
    Saab AB, Sweden.
    Karlsson, Emil
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering.
    Lööw, Tomas
    Saab AB, Sweden.
    Rönnberg, Elina
    Linköping University, Department of Mathematics, Optimization . Linköping University, Faculty of Science & Engineering.
    A constraint generation procedure for pre-runtime scheduling of integrated modular avionic systems2017In: Proceedings of the 13th Workshop on Models and Algorithms for Planning and Scheduling Problems / [ed] Susanne Albers, Nicole Megow, Andreas S. Schulz, Leen Stougie, 2017Conference paper (Other academic)
    Abstract [en]

    In modern integrated modular avionic systems, applications share hardware resources on a common avionic platform. Such an architecture necessitates strict requirements on the spatial and temporal partitioning of the system to prevent fault propagation between different aircraft functions. One way to establish a temporal partitioning is through pre-runtime scheduling of the system, which involves creating a schedule for both tasks and a communication network.

    While the avionic systems are growing more and more complex, so is the challenge of scheduling them. Scheduling of the system has an important role in the development of new avionic systems since functionality typically is added to the system over a period of several years and a scheduling tool is used both to detect if the platform can host the new functionality and, in case this is possible, to create a new schedule. For this reason an exact solution strategy for avionics scheduling is preferred over a heuristic one.

    In this paper we present a mathematical model for an industrially relevant avionic system and present a constraint generation  procedure for scheduling of such systems. We apply our optimisation approach to instances provided by our industrial partner. These instances are of relevance for the development of future avionic systems and contain up to 20 000 tasks to be scheduled. The computational results show that our optimisation approach can be used to create schedules for such instances within reasonable time.

  • 23.
    Sciarretta, A.
    et al.
    IFP Energies Nouvelles, France .
    Serrao, L.
    Dana Corporation, Italy.
    Dewangan, P.C.
    IFP Energies Nouvelles, France; IFP School, France .
    Tona, P.
    IFP Energies Nouvelles, France .
    Bergshoeff, E.N. D.
    TU Eindhoven, Netherlands.
    Bordons, C.
    University of Seville, Spain .
    Charmpa, L.
    IFP Sch, France Continental, France .
    Elbert, Ph.
    ETH Zurich, Switzerland.
    Eriksson, Lars
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Hofman, T.
    TU Eindhoven, Netherlands .
    Hubacher, M.
    TU Eindhoven, Netherlands .
    Isenegger, R.
    TU Eindhoven, Netherlands .
    Lacandia, F.
    Ohio State University, USA.
    Laveau, A.
    IFP School, France.
    Li, H.
    IFP School, France.
    Marcos, D.
    University of Seville, Spain .
    Nueesch, T.
    ETH Zurich, Switzerland.
    Onori, S.
    Ohio State University, USA .
    Pisu, P.
    Clemson University, USA .
    Rios, J.
    Clemson University, USA .
    Silvas, E.
    TU Eindhoven, Netherlands .
    Sivertsson, Martin
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, The Institute of Technology.
    Tribioli, L.
    Ohio State University, USA .
    van der Hoeven, A.-J.
    TU Eindhoven, Netherlands .
    Wu, M.
    IFP School, France.
    A control benchmark on the energy management of a plug-in hybrid electric vehicle2014In: Control Engineering Practice, ISSN 0967-0661, Vol. 29, 287-298 p.Article in journal (Refereed)
    Abstract [en]

    A benchmark control problem was developed for a special session of the IFAC Workshop on Engine and Powertrain Control, Simulation and Modeling (E-COSM 12), held in Rueil-Malmaison, France, in October 2012. The online energy management of a plug-in hybrid-electric vehicle was to be developed by the benchmark participants. The simulator, provided by the benchmark organizers, implements a model of the GM Voltec powertrain. Each solution was evaluated according to several metrics, comprising of energy and fuel economy on two driving profiles unknown to the participants, acceleration and braking performance, computational performance. The nine solutions received are analyzed in terms of the control technique adopted (heuristic rule-based energy management vs. equivalent consumption minimization strategies, ECMS), battery discharge strategy (charge depleting-charge sustaining vs. blended mode), ECMS implementation (vector-based vs. map-based), ways to improve the implementation and improve the computational performance. The solution having achieved the best combined score is compared with a global optimal solution calculated offline using the Pontryagins minimum principle-derived optimization tool HOT.

  • 24.
    Bengtsson, Mikael
    Linköping University, Department of Electrical Engineering, Vehicular Systems. Linköping University, Faculty of Science & Engineering.
    A Control-Oriented 0D Model of a Turbocharger Gas Stand Including Heat Transfer2015Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    A turbocharger’s performance is measured in a gas stand in order to provide information of the components characteristics. The measurement procedure is a very time consuming process and it is thus desired to make it more time-efficient.

    To allow for development of an enhanced control strategy used during the measurements, a 0D model of a gas stand is developed. The physical gas stand components are modeled and validated against measurements, all showing a reasonable result. Turbocharger heat transfers are investigated and modeled using a lumped capacitance approach. The heat transfer models shows approximative results when comparing with measurements which is explained by the lack of temperature measurement made on the bearing housing.

    When the complete gas stand model is validated against measurements, an improvement of the measurement procedure is examined. By adding an idealized heat source with the possibility to heat the compressor housing, it is possible to reduce the time it takes to reach an equilibrium when switching between two steady state operating points. 

  • 25.
    Dolphin, Gunnar
    Linköping University, The Institute of Technology. Linköping University, Department of Physics, Chemistry and Biology.
    A designed branched three-helix bundle protein dimer2006In: Journal of the American Chemical Society, ISSN 0002-7863, Vol. 128, no 22, 7287-7290 p.Article in journal (Refereed)
    Abstract [en]

    The ultimate goals of de novo protein design are the construction of novel tertiary structures and functions. Here is presented the design and synthesis of a uniquely branched three-helix bundle that folds into a well-folded dimeric protein. The branching of this protein was performed by the method of native chemical ligation, which provides a chemoselective and stable amide bond between the unprotected fragments. This ligation strategy was possible by the presented facile preparation of a peptide (43 amino acids) with a specific side chain thioester, which is synthesized by general Fmoc solid phase peptide synthesis. From the presented structural analysis, it is seen that the folded protein is present as a stable and highly helical dimer, thus forming a six-helix bundle. This unique tertiary structure, composed of a dimer of three individual a-helices branched together, offers different possibilities for protein engineering, such as metal and cofactor binding sites, as well as for the construction of novel functions. © 2006 American Chemical Society.

  • 26.
    Xu, Jin Wei
    et al.
    Bioinformatics Research Group School of Engineering and Information Technology The University of New South Wales Canberra, ACT 2600, Australia .
    Pham, Tuan D.
    Bioinformatics Research Group School of Engineering and Information Technology The University of New South Wales Canberra, Australia .
    Zhou, Xiaobo
    The Methodist Hospital Research Institute Cornell University Houston, TX 77030, USA.
    A double thresholding method for cancer stem cell detection2011Conference paper (Refereed)
    Abstract [en]

    Image analysis of cancer cells is important for cancer diagnosis and therapy, because it recognized as the most efficient and effective way to observe its proliferation. For the purpose of adaptive and accurate cancer cell image segmentation, a double threshold segmentation method is proposed in this paper. Based on a single gray-value histogram of the RGB color space, a double threshold, the key parameters of threshold segmentation can be fixed by a fitted-curve of the RGB component histogram. As reasonable thresholds confirmed, binary segmentation dependent on two thresholds, will be put into practice and result in binary image. With the post-processing of mathematical morphology and division of whole image, the better segmentation result can be finally achieved. By the comparison with other advanced segmentation methods such as level set and active contour, the proposed double thresholding has been found as the simplest strategy with shortest processing time as well as highest accuracy. The proposed method can be effectively used in the detection and recognition of cancer stem cells in images.

  • 27.
    Axehill, Daniel
    et al.
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    Hansson, Anders
    Linköping University, Department of Electrical Engineering, Automatic Control. Linköping University, The Institute of Technology.
    A Dual Gradient Projection Quadratic Programming Algorithm Tailored for Mixed Integer Predictive Control2008Report (Other academic)
    Abstract [en]

    The objective of this work is to derive a Mixed Integer Quadratic Programming algorithm tailored for Model Predictive Control for hybrid systems. The Mixed Integer Quadratic Programming algorithm is built on the branch and bound method, where Quadratic Programming relaxations of the original problem are solved in the nodes of a binary search tree. The difference between these subproblems is often small and therefore it is interesting to be able to use a previous solution as a starting point in a new subproblem. This is referred to as a warm start of the solver. Because of its warm start properties, an algorithm that works similar to an active set method is desired. A drawback with classical active set methods is that they often require many iterations in order to find the active set in optimum. So-called gradient projection methods are known to be able to identify this active set very fast. In the algorithm presented in this report, an algorithm built on gradient projection and projection of a Newton search direction onto the feasible set is used. It is a variant of a previously presented algorithm by the authors and makes it straightforward to utilize the previous result, where it is shown how the Newton search direction for the dual MPC problem can be computed very efficiently using Riccati recursions. As in the previous work, this operation can be performed with linear computational complexity in the prediction horizon. Moreover, the gradient computation used in the gradient projection part of the algorithm is also tailored for the problem in order to decrase the computational complexity. Furthermore, is is shown how a Riccati recursion still can be useful in the case when the system of equations for the ordinary search directino is inconsistent. In numerical experiments, the algorithm shows good performance, and it seems like the gradient projection strategy efficiently cuts down the number of Newton steps necessary to compute in order to reach the solution. When the algorithm is used as a part of an MIQP solver for hybrid MPC, the performance is still very good for small problems. However, for more difficult problems, there still seems to be some more work to do in order to get the performance of the commercial state-of-the-art solver CPLEX.

  • 28.
    Säll, Erik
    et al.
    Linköping University, Department of Electrical Engineering.
    Andersson, Ola
    Linköping University, Department of Electrical Engineering.
    Vesterbacka, Mark
    Linköping University, Department of Electrical Engineering. Linköping University, Department of Electrical Engineering, Electronics System.
    A dynamic element matching technique for flash analog-to-digital converters2004In: Proc. 8th Nordic Signal Processing Symp., NORSIG'04, 2004, 137-140 p.Conference paper (Refereed)
    Abstract [en]

    A flash analog-to-digital converter is proposed that employs a new dynamic element matching architecture. The architecture uses a new strategy of incorporating switches in the voltage reference generator that allows lower hardware complexity and higher conversion speed than comparable converters. The converter has been modeled and simulated on a behavioral level in Matlab. The results indicate good linearity properties that together with the expected speed performance should make it suitable in intended communications applications.

  • 29.
    Karlsson, B
    et al.
    Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
    Karlsson, N
    Defence Research Establishment, Linköping.
    Wide, P
    Örebro University.
    A dynamic safety system based on sensor fusion2000In: Journal of Intelligent Manufacturing, ISSN 0956-5515, Vol. 11, no 5, 475-483 p.Article in journal (Refereed)
    Abstract [en]

    Machines in industry, including industrial robots, have in many cases dramatically reduced the man-made work and improved the work environment. New machines introduce, however, new risk factors. Traditionally machines are safeguarded by means that more or less rigidly separates the machines from the personnel. This works well in many traditional areas, i.e., where industrial robots are involved. There is however a risk that the safety system limits the valuable flexibility of the robot, which can be considered as a quality that tends to become even more valuable in the progress of programming possibilities and sensor technology. This article shows an example how a safety system can be designed to achieve increased flexibility in co-operation between human and production safety strategy. The proposed safety system is totally based on sensor information that monitors the working area, calculate the safety level and improve the system dynamically, e.g., reduce the robot capability in conjunction to the system safety level. The safety system gain information from the sensors and calculates a risk level which controls the robot speed, i.e., the speed is reduced to achieve a sufficiently low risk level. The sensor data is combined with fuzzy-based sensor fusion and fuzzy rules. The safety system is based on sensor information, hence it automatically adjusts to changes in the guarded area as long as the functionality of the sensors is maintained. Finally, we present a system implementation in an industrial robot application.

  • 30.
    Hu, Zhang-Jun
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, The Institute of Technology. Tongji University, Shanghai, China .
    Hu, Jiwen
    Tongji University, Shanghai, China .
    Cui, Yang
    Tongji University, Shanghai, China .
    Wang, Guannan
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, The Institute of Technology.
    Zhang, Xuanjun
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, The Institute of Technology.
    Uvdal, Kajsa
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Surface Physics and Nano Science. Linköping University, The Institute of Technology.
    Gao, Hong-Wen
    Tongji University, Shanghai, China .
    A facile "click" reaction to fabricate a FRET-based ratiometric fluorescent Cu2+ probe2014In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 2, no 28, 4467-4472 p.Article in journal (Refereed)
    Abstract [en]

    A facile one-step Cu(I)-catalyzed "click" reaction, between a dansyl-azide and a propargyl-substituted rhodamine B hydrazide, is employed to fabricate a novel FRET ratiometric "off-on" fluorescent probe. The sensitive emission of the donor, a dansyl group, overlaps perfectly with the absorption of the acceptor, xanthene in the open-ring rhodamine. The proposed probe shows high selectivity towards Cu2+. The ratio of emission intensities at 568 and 540 nm (I-568/I-540) exhibits a drastic 28-fold enhancement upon addition of Cu2+. The probe shows an excellent linear relationship between emission ratios and the concentrations of Cu2+ from 10 to 50 mu M, with a detection limit (S/N = 3) of 0.12 mu M. The preliminary cellular studies demonstrated that the probe is cell membrane permeable and could be applied for ratiometric fluorescence imaging of intracellular Cu2+ with almost no cytotoxicity. The ingenuity of the probe design is to construct a FRET donor-acceptor interconnector and a selective receptor simultaneously by "click" reaction. The strategy was verified to have great potential for developing novel FRET probes for Cu2+.

  • 31.
    Ma, Zaifei
    et al.
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Dang, Dongfeng
    Chalmers, Sweden Xiangtan University, Peoples R China .
    Tang, Zheng
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Gedefaw, Desta
    Chalmers, Sweden .
    Bergqvist, Jonas
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Zhu, Weiguo
    Xiangtan University, Peoples R China .
    Mammo, Wendimagegn
    University of Addis Ababa, Ethiopia .
    Andersson, Mats R.
    Chalmers, Sweden .
    Inganäs, Olle
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Zhang, Fengling
    Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
    Wang, Ergang
    Chalmers, Sweden .
    A Facile Method to Enhance Photovoltaic Performance of Benzodithiophene-Isoindigo Polymers by Inserting Bithiophene Spacer2014In: ADVANCED ENERGY MATERIALS, ISSN 1614-6832, Vol. 4, no 6Article in journal (Refereed)
    Abstract [en]

    A series of conjugated polymers containing benzodithiophene as donor and isoindigo as acceptor with no, one, two and three thiophene spacer groups is synthesized and characterized. The polymer with bithiophene as a spacer has a superior efficiency of 7.31% in solar cells. This demonstrates an important design strategy to produce polymers for high-performance solar cells by inserting thiophene spacer groups.

  • 32.
    Bårman, Håkan
    et al.
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    Knutsson, Hans
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    Granlund, Gösta H.
    Linköping University, Department of Electrical Engineering, Computer Vision. Linköping University, The Institute of Technology.
    A Filtering Strategy for Orientation and Curvature Description1989In: The 6th Scandinavian Conference on Image Analysis: Oulu, Finland, 1989, 886-889 p.Conference paper (Refereed)
  • 33.
    Duma, Claudiu
    et al.
    Linköping University, The Institute of Technology. Linköping University, Department of Computer and Information Science, Database and information techniques.
    Shahmehri, Nahid
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    Lambrix, Patrick
    Linköping University, Department of Computer and Information Science, Database and information techniques. Linköping University, The Institute of Technology.
    A flexible category-based collusion-resistant key management scheme for multicast2003In: Security and privacy in the age of uncertainty: IFIP TC11 18th International Conference on Information Security (SEC2003) May 26-28, 2003, Athens, Greece / [ed] Dimitris Gritzalis; Sabrina De Capitani di Vimercati; Pierangela Samarati; Sokratis Katsikas, Kluwer Academic Publishers, 2003, 133-144 p.Conference paper (Refereed)
    Abstract [en]

    Current key management schemes for multicast provide either no resistance to collusion or perfect resistance to collusion. However, resistance to collusion is achieved at the expense of efficiency in terms of the number of transmissions and the number of keys that are used. We argue that applications may have certain assumptions regarding the users and their access to the multicast channel that may be used to provide a broader range of choices for balancing efficiency against resistance to collusion.

    We formalize the collusion requirement based upon the users' access to the multicast channel. Different user categorizations give different degrees of collusion resistance and we show that the existing work has focused on special cases of user categorizations. Further, we go on to propose and evaluate a flexible key management strategy for the general case where the accessibility relation defines the order of exclusion of the categories. The theoretical and experimental results show that our scheme has good performance regarding transmissions and keys per controller.

  • 34.
    Wang, Qunzhi
    et al.
    Department of Industrial Engineering and Management Tokyo Institute of Technology.
    Tang, Ou
    Linköping University, The Institute of Technology. Linköping University, Department of Production Economics.
    Tsao, De-bi
    Department of Industrial Engineering and Management Tokyo Institute of Technology.
    A flexible contract strategy in a supply chain with an inflexible production mode2006In: International Journal of Operational Research, ISSN 1745-7645, Vol. 1, no 3, 228-248 p.Article in journal (Refereed)
    Abstract [en]

    This paper presents a flexible supply contract with call options model for an inflexible supply chain, where the supplier only has an opportunity to produce one batch due to a long lead-time limitation. In such systems, there are eventually two decision points. At the beginning of the planning horizon, the supplier offers a wholesale price, and possibly also option purchasing and exercising prices. In addition to a firm initial order, the buyer can purchase options to adjust order quantity later. The supplier then determines the production volume. At the second decision point, with updated forecast, the buyer finalises the order quantity by exercising options. We formulate both the buyer's and the supplier's profit functions. Furthermore, we develop explicit expressions to determine the buyer's optimal decisions, and calculate the supplier's optimal decisions numerically. In numerical study, we illustrate that such a flexible contract strategy improves both the buyer's and supplier's profits. Copyright © 2006 Inderscience Enterprises Ltd.

  • 35.
    Lindblom, Sofie
    Linköping University, Department of Science and Technology, Media and Information Technology. Linköping University, The Institute of Technology.
    A framework for disruptive innovation in an industry where everything is innovative2015Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
    Abstract [en]

    This master thesis is written as a part of The Media Technology program at Linköping University in collaboration with the streaming music company Spotify. The thesis investigates how a software company in the modern age effectively and organically can stay innovative through times. The thesis maps out strategies, models and methods currently known, analyses Spotify’s innovative efforts over the past year and suggests a framework tailored to the needs of the company.

  • 36.
    Flodström, Raquel
    Linköping University, Department of Management and Engineering. Linköping University, The Institute of Technology.
    A Framework for the Strategic Management of Information Technology2006Licentiate thesis, monograph (Other academic)
    Abstract [en]

    Strategy and IT research has been extensively discussed during the past 40 years. Two scientific disciplines Management Science (MS) and Management Information Science (MIS) investigate the importance of IT as a competitive factor. However, although much research is available in both disciplines, it is still difficult to explain how to manage IT to enable competitive advantages. One reason is that MS research focuses on strategies and competitive environments but avoids the analysis of IT. Another reason is that MIS research focuses on IT as a competitive factor but avoids the analysis of the competitive environment. Consequently, there is a gap of knowledge in the understanding of the strategic management of information technology (SMIT).

    The strategic analysis of IT as a competitive factor is important for achieving the competitive advantages of IT. This thesis explores factors related to strategy and IT that should be considered for the strategic analysis of IT as a competitive factor, and proposes a framework for SMIT. The research is conducted by means of a qualitative analysis of theoretical data from the disciplines of MS and MIS. Data is explored to find factors related to SMIT.

    The results of the analysis show that the strategic management of information technology is a continuous process of evaluation, change, and alignment between factors such as competitive environment, competitive strategies (business and IT strategies), competitive outcome, and competitive factors (IT). Therefore, the understanding of the relationships between these factors is essential in order to achieve the competitive advantages of using IT.

    This thesis contributes to strategic management research by clarifying the relationships between strategic management, competitive environment, and IT as competitive factor into a holistic framework for strategic analysis. The framework proposed is valuable not only for business managers and for IT managers, but also for academics. The framework is designed to understand the relationship between competitive elements during the process of strategic analysis prior to the formulation of competitive strategies. Moreover, it can also be used as a communication tool between managers, in order to achieve alignment among company strategies. To academics, this thesis presents the state-of-the-art related to strategic management research; it can also be a valuable reference for strategic managers, as well as researchers interested in the strategic management of IT.

  • 37.
    Ahlström, Christer
    et al.
    Swedish National Road and Transport Research Institute, Linköping, Sweden.
    Kircher, Katja
    Swedish National Road and Transport Research Institute, Linköping, Sweden.
    Kircher, Albert
    Östergötlands Läns Landsting, Heart and Medicine Center, Department of Clinical Physiology in Linköping.
    A Gaze-Based Driver Distraction Warning System and Its Effect on Visual Behavior2013In: IEEE transactions on intelligent transportation systems (Print), ISSN 1524-9050, E-ISSN 1558-0016, Vol. 14, no 2, 965-973 p.Article in journal (Refereed)
    Abstract [en]

    Driver distraction is a contributing factor to many crashes; therefore, a real-time distraction warning system should have the potential to mitigate or circumvent many of these crashes. The objective of this paper is to investigate the usefulness of a real-time distraction detection algorithm called AttenD. The evaluation is based on data from an extended field study comprising seven drivers who drove on an average of 4351 +/- 2181 km in a naturalistic setting. Visual behavior was investigated both on a global scale and on a local scale in the surroundings of each warning. An increase in the percentage of glances at the rear-view mirror and a decrease in the amount of glances at the center console were found. The results also show that visual time sharing decreased in duration from 9.94 to 9.20 s due to the warnings, that the time from fully attentive to warning decreased from 3.20 to 3.03 s, and that the time from warning to full attentiveness decreased from 6.02 to 5.46 s. The limited number of participants does not allow any generalizable conclusions, but a trend toward improved visual behavior could be observed. This is a promising start for further improvements of the algorithm and the warning strategy.

  • 38.
    Bruhn, Sören
    et al.
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Fang, Yu
    Guiyang Medical Coll, Peoples R China University of Gothenburg, Sweden .
    Barrenäs, Fredrik
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Gustafsson, Mika
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Zhang, Huan
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Konstantinell, Aelita
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Kronke, Andrea
    Cenix BioScience GmbH, Germany .
    Sonnichsen, Birte
    Cenix BioScience GmbH, Germany .
    Bresnick, Anne
    Albert Einstein Coll Med, NY 10461 USA .
    Dulyaninova, Natalya
    Albert Einstein Coll Med, NY 10461 USA .
    Wang, Hui
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Zhao, Yelin
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Klingelhofer, Jorg
    University of Copenhagen, Denmark .
    Ambartsumian, Noona
    University of Copenhagen, Denmark .
    Beck, Mette K.
    Technical University of Denmark, Denmark .
    Nestor, Colm
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences.
    Bona, Elsa
    Boras Hospital, Sweden .
    Xiang, Zou
    University of Gothenburg, Sweden .
    Benson, Mikael
    Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart and Medicine Center, Allergy Center. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
    A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy2014In: Science Translational Medicine, ISSN 1946-6234, E-ISSN 1946-6242, Vol. 6, no 218Article in journal (Refereed)
    Abstract [en]

    The identification of diagnostic markers and therapeutic candidate genes in common diseases is complicated by the involvement of thousands of genes. We hypothesized that genes co-regulated with a key gene in allergy, IL13, would form a module that could help to identify candidate genes. We identified a T helper 2 (T(H)2) cell module by small interfering RNA-mediated knockdown of 25 putative IL13-regulating transcription factors followed by expression profiling. The module contained candidate genes whose diagnostic potential was supported by clinical studies. Functional studies of human TH2 cells as well as mouse models of allergy showed that deletion of one of the genes, S100A4, resulted in decreased signs of allergy including TH2 cell activation, humoral immunity, and infiltration of effector cells. Specifically, dendritic cells required S100A4 for activating T cells. Treatment with an anti-S100A4 antibody resulted in decreased signs of allergy in the mouse model as well as in allergen-challenged T cells from allergic patients. This strategy, which may be generally applicable to complex diseases, identified and validated an important diagnostic and therapeutic candidate gene in allergy.

  • 39.
    Eriksson, Björn
    et al.
    Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems. Linköping University, The Institute of Technology.
    Rösth, Marcus
    MCD Parker Hannifin AB.
    Palmberg, Jan-Ove
    Linköping University, Department of Mechanical Engineering, Fluid and Mechanical Engineering Systems. Linköping University, The Institute of Technology.
    A High Energy Efficient Mobile Fluid Power System: Novel System Layout and Measurements2008Conference paper (Other academic)
    Abstract [en]

    This is one of the earliest publications of the proposed energy efficient individual metering system shown in chapter 5, section 5.3.3. This paper introduces the novel system design, which utilizes independent meter-in and meter-out valves. This system design has the potential to increase energy efficiency considerably in a system that consists of a pump  connected to more than one fluid power actuator. The system proposed here is not dependent on pressure transducers for either flow control or mode selection. The main difference between the work presented in this paper and earlier work is the control strategy. The output signal choices in the closed loops are new. Some functionality is kept in hardware to avoid  critical sensor dependency. The presented system uses pressure compensators to achieve desired flows.

  • 40.
    Bach, Anders
    et al.
    University of Copenhagen.
    Clausen, Bettina H
    University of South Denmark.
    Moller, Magda
    University of Copenhagen.
    Vestergaard, Bente
    University of Copenhagen.
    Chi, Celestine N
    Uppsala University.
    Round, Adam
    European Molecular Biol Lab.
    Sorensen, Pernille L
    University of Copenhagen.
    Nissen, Klaus B
    University of Copenhagen.
    Kastrup, Jette S
    University of Copenhagen.
    Gajhede, Michael
    University of Copenhagen.
    Jemth, Per
    Uppsala University.
    Kristensen, Anders S
    University of Copenhagen.
    Lundström, Patrik
    Linköping University, Department of Physics, Chemistry and Biology, Molecular Biotechnology. Linköping University, The Institute of Technology.
    Lambertsen, Kate L
    University of South Denmark.
    Stromgaard, Kristian
    University of Copenhagen.
    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage2012In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 109, no 9, 3317-3322 p.Article in journal (Refereed)
    Abstract [en]

    Inhibition of the ternary protein complex of the synaptic scaffolding protein postsynaptic density protein-95 (PSD-95), neuronal nitric oxide synthase (nNOS), and the N-methyl-D-aspartate (NMDA) receptor is a potential strategy for treating ischemic brain damage, but high-affinity inhibitors are lacking. Here we report the design and synthesis of a novel dimeric inhibitor, Tat-NPEG4(IETDV)(2) (Tat-N-dimer), which binds the tandem PDZ1-2 domain of PSD-95 with an unprecedented high affinity of 4.6 nM, and displays extensive protease-resistance as evaluated in vitro by stability-measurements in human blood plasma. X-ray crystallography, NMR, and small-angle X-ray scattering (SAXS) deduced a true bivalent interaction between dimeric inhibitor and PDZ1-2, and also provided a dynamic model of the conformational changes of PDZ1-2 induced by the dimeric inhibitor. A single intravenous injection of Tat-N-dimer (3 nmol/g) to mice subjected to focal cerebral ischemia reduces infarct volume with 40% and restores motor functions. Thus, Tat-N-dimer is a highly efficacious neuroprotective agent with therapeutic potential in stroke.

  • 41.
    Lunneryd, Sven Gunnar
    et al.
    National Board of Fisheries, Tja¨rno¨ Marine Biological Laboratory, SE-452 96 Strömstad, Sweden.
    Fjälling, Arne
    Linköping University, Department of Physics, Chemistry and Biology, Zoology . Linköping University, The Institute of Technology.
    Westerberg, Håkan
    National Board of Fisheries, Box 423, SE-401 26 Gothenburg, Sweden..
    A large-mesh salmon trap: a way of mitigating seal impact on a coastal fishery2003In: ICES Journal of Marine Science, ISSN 1054-3139, E-ISSN 1095-9289, Vol. 60, no 6, 1194-1199 p.Article in journal (Refereed)
    Abstract [en]

    A new design for a salmon trap aimed at minimizing damage to catch and gear caused by grey seals was tested. The traditional trap design used in the northern Baltic permits an efficient hunting strategy by seals, whereby chased fish entangle themselves in the side panels and can then easily be taken, with associated damage to the net. The side panels of the test trap (excluding the fish chamber) are made of large-mesh (400 mm) netting compared to ≤200 mm in traditional traps. This should allow seal-chased and panicking salmon to pass through, while less stressed individuals should still be guided efficiently towards the fish chamber. Trials with the two trap types were performed at the mouth of the river Indal (northern Sweden) in a comparative test programme. Catches of salmon and trout in the test trap were larger than in the standard trap. We estimated that 65% of the potential catch was lost in the standard trap owing to seal predation, while escape rate through the large meshes in the test trap was 52%. The standard trap had a total of 269 holes owing to seal damage, while only six holes were found in the test trap. Seal activity in and around the standard trap was up to 16 times higher compared with the test trap and decreased considerably during the following year when only large-meshed traps were used in the area. We suggest that seals are difficult to deter from fishing gear as long as they get a reward in terms of food and propose that a strategy that deprives seals of a reward will make the gear uninteresting to them and may have long-term mitigation effects.

  • 42.
    Nolén, Sixten
    et al.
    Linköping University, Department of Department of Health and Society, Division of Preventive and Social Medicine and Public Health Science. Linköping University, Faculty of Health Sciences.
    Lindqvist, Kent
    Linköping University, Department of Department of Health and Society, Division of Preventive and Social Medicine and Public Health Science. Linköping University, Faculty of Health Sciences.
    A local bicycle helmet ‘law’ in a Swedish municipality: the structure and process of initiation and implementation2002In: Injury control and safety promotion, ISSN 1566-0974, Vol. 9, no 2, 89-98 p.Article in journal (Refereed)
    Abstract [en]

    On May 1, 1996, the Municipality of Motala in Sweden introduced a local bicycle helmet ‘law.’ It is, however, not an official law in a legal sense, but a municipally endorsed recommendation supported by promotional activities. This ‘law’ applies to children (ages 6–12), although the objective is to increase helmet use among cyclists of all ages. The study is a qualitative evaluation of the structure and process during initiation and implementation of the Motala bicycle helmet law. The aim was to describe the activities that were carried out, which actors took part and the opinions of the most closely involved actors. The results are based on analysis of written material and on interviews with eight of the actors. The mass media focused much attention on the bicycle helmet law, especially during the first six months after its introduction. The name helmet law was presumably of significance in this context. It is essential that relevant target groups provide sufficient support and that committed individuals initiate and promote the work, which, however, must not become dependent on a single individual. All issues concerning bicycle helmets should be coordinated with the law. Also, continuous engagement of the municipal government and a strategy for the control and follow-up of the law are needed. Local bicycle helmet laws of this type have a potential to produce a long-lasting effect on helmet use, provided some of the problems encountered can be avoided and some of the promotional activities are intensified.

  • 43.
    Jungert, Tomas
    Linköping University, Department of Behavioural Sciences and Learning, Clinical and Social Psychology. Linköping University, Faculty of Arts and Sciences.
    A longitudinal study of engineering students’ approaches to their studies2008In: Higher Education Research and Development, ISSN 0729-4360, Vol. 27, no 3, 201-214 p.Article in journal (Refereed)
    Abstract [en]

     

    This longitudinal study draws on data from a larger project and examines how students’ perceptions of their opportunities to influence their study environment may be enacted in approaches aimed at influencing their studies, and whether this changes during the course of their studies. Ten students from a 4.5-year Master’s programme in Engineering were studied throughout their education by means of semi-structured in-depth interviews, which were analysed thematically. The results indicate that students’ perceptions of their study environment were enacted in three approaches aimed at influencing their study environment: (i) to adapt to the environment and to study alone;(ii) to try to change the programme, to create an individual curriculum and to interact with teachers; and (iii) to cooperate with their peers. The thematic analysis suggests that students’ perceptions of their study environment were enacted in the different approaches and that these changed along with external demands in the programme.

     

  • 44.
    Lagerqvist, B.
    et al.
    Department of Cardiology, University Hospital, S-751 85 Uppsala, Sweden.
    Husted, S.
    Department of Cardiology, University Hospital, Aarhus, Denmark.
    Kontny, F.
    Heart and Lung Centre, Ullevål University Hospital, Oslo, Norway.
    Naslund, U.
    Näslund, U., Department of Cardiology, Heart Centre, University Hospital, Umeå, Sweden.
    Stahle, E.
    Ståhle, E., Department of Thoracic Surgery, University Hospital, S-751 85 Uppsala, Sweden.
    Swahn, Eva
    Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Health Sciences, Cardiology . Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
    Wallentin, L.
    Department of Cardiology, University Hospital, S-751 85 Uppsala, Sweden.
    A long-term perspective on the protective effects of an early invasive strategy in unstable coronary artery disease: Two-year follow-up of the FRISC-II Invasive Study2002In: Journal of the American College of Cardiology, ISSN 0735-1097, Vol. 40, no 11, 1902-1914 p.Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: We sought to report the first and repeat events and to separate spontaneous and procedure-related events over two years in the Fast Revascularization during InStability in Coronary artery disease (FRISC-II) invasive trial. BACKGROUND: The FRISC-II invasive trial compared the long-term effects of an early invasive versus noninvasive strategy, in terms of death and myocardial infarction (MI) and the need for repeat hospital admissions and late revascularization procedures in patients with coronary artery disease (UCAD). METHODS: In the FRISC-II trial, 2,457 patients with UCAD were randomized to an early invasive or noninvasive strategy. RESULTS: At 24 month follow-up, there were reductions in mortality (n = 45 [3.7%] vs. 67 [5.4%], risk ratio 0.68 [95% confidence interval (CI) 0.47 to 0.98], p = 0.038), MI (n = 111 [9.2%] vs. 156 [12.7%], risk ratio 0.72 [95% CI 0.57 to 0.91], p = 0.005), and the composite end point of death or MI (n = 146 [12.1%] vs. 200 [16.3%], risk ratio 0.74 [95% CI 0.61 to 0.90], p = 0.003) in the invasive compared with the noninvasive group. Procedure-related MIs were two to three times more common, but spontaneous ones were three times less common in the invasive than in the noninvasive group. After the first year, there was no difference in mortality (n = 20 [1.7%]) between the two groups and fewer MIs in the invasive group (p = 0.031). CONCLUSIONS: In UCAD, the early invasive approach leads to a sustained reduction in mortality, cardiac morbidity, and the need for repeat hospital admissions and late revascularization procedures. Although the benefits are greatest during the first months, during the second year, cardiac morbidity is lower and the need for hospital care is less in the invasive group. © 2002 by the American College of Cardiology Foundation.

  • 45.
    Glaas, Erik
    Linköping University, The Tema Institute, Centre for Climate Science and Policy Research . Linköping University, The Tema Institute, Department of Water and Environmental Studies. Linköping University, Faculty of Arts and Sciences.
    A mapping of climate change risks and adaptation guidelines to house owners in Denmark, Norway and Sweden2014Report (Other academic)
    Abstract [en]

    This briefing informs on ongoing research within the project “Increasing Nordic homeowners adaptive capacity to climate change: research of opinions and development of a web-based tool” (In hac Vita) financed by Nordforsk. The project is subordinated the Nordic Centre of Excellence for Strategic Adaptation Research (NORD-STAR) which aims at bridging the gaps between adaptation science, practice and policy, and at helping public and private stakeholders at all levels to improve strategy development and decision-making. Since this is ongoing research, results and discussions presented in this text should be seen as preliminary.

  • 46.
    Hadera, Hubert
    et al.
    Technical University of Dortmund, Germany.
    Wide, Per
    Linköping University.
    Harjunkoski, Iiro
    ABB Corporate Research, Germany.
    Mäntysaari, Juha
    ABB Oy Industry Solutions, Finland.
    Ekström, Joakim
    Linköping University, Department of Science and Technology, Communications and Transport Systems. Linköping University, Faculty of Science & Engineering.
    Sand, Guido
    ABB Corporate Research, Germany.
    Engell, Sebastian
    Technical University of Dortmund, Germany.
    A Mean Value Cross Decomposition Strategy for Demand-side Management of a Pulping Process2015In: 12th International Symposium on Process Systems Engineering and 25th European Symposium on Computer Aided Process Engineering / [ed] Krist V. Gernaey, Jakob K. Huusom and Gani Rafiqul, Elsevier , 2015, Vol. 37, 1931-1936 p.Chapter in book (Refereed)
    Abstract [en]

    Energy is becoming a critical resource for process industries as introduction of new policies drive changes in the energy supply systems. Energy availability and pricing is much more volatile. In this study, we propose a Mean Value Cross Decomposition approach to functionally separate production scheduling from energy-cost optimization. Such a decomposition makes it possible to exploit existing optimization solutions avoiding a need to create a new monolithic model. The proposed framework is applied to a continuous process of thermo-mechanical pulping using a discrete-time Resource-Task Network model. Example case study scenarios show that the approach gives optimal system-wide solutions while keeping the models separated.

  • 47.
    Gupta, Anil
    et al.
    Linköping University, Department of Medical and Health Sciences, Anesthesiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Sinnescentrum, Department of Anaesthesiology and Surgery UHL.
    Favaios, S.
    EPE.
    Perniola, A.
    Orebro University Hospital.
    Magnuson, A.
    University Orebro.
    Berggren, L.
    Orebro University Hospital.
    A meta-analysis of the efficacy of wound catheters for post-operative pain management2011In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 55, no 7, 785-796 p.Article, review/survey (Refereed)
    Abstract [en]

    Local anesthetics (LA) are injected via catheters placed in surgical wounds for post-operative analgesia. The primary aim of this systematic review was to assess whether LA reduce pain intensity when injected via wound catheters. A literature search was performed from Medline via PubMed, EMBASE and the Cochrane database from 1966 until November 2009. The search strategy included the following key words: pain, postoperative, catheters and local anesthetics. Two co-authors independently read every article that was initially included and extracted data into a pre-defined study record form. A total of 753 studies primarily fit the search criteria and 163 were initially extracted. Of these, 32 studies were included in the meta-analysis. Wound catheters provided no significant analgesia at rest or on activity, except in patients undergoing gynecological and obstetric surgery at 48 h (P = 0.03). The overall morphine consumption was lower (approximate to 13 mg) during 0-24 h (P less than 0.001) in these patients. No significant differences in side effects were found, except for a lower risk of wound breakdown (P = 0.048) and a shorter length of hospital stay (P = 0.04) in patients receiving LA. A statistically significant heterogeneity was seen between the studies in most end-points. LA injected via wound catheters did not reduce pain intensity, except at 48 h in a subgroup of patients undergoing obstetric and gynecological surgery. Rescue analgesic consumption was also lower in this group at 0-24 h. The magnitude of these effects was small and compounded by pronounced heterogeneity.

  • 48.
    Svedjeholm, Rolf
    et al.
    Linköping University, Department of Medicine and Health Sciences, Thoracic Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery.
    Vidlund, Marten
    Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery. Linköping University, Faculty of Health Sciences.
    Vanhanen, Ingemar
    Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery. Linköping University, Faculty of Health Sciences.
    Hakanson, Erik
    Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery. Linköping University, Faculty of Health Sciences.
    A metabolic protective strategy could improve long-term survival in patients with LV-dysfunction undergoing CABG2010In: SCANDINAVIAN CARDIOVASCULAR JOURNAL, ISSN 1401-7431, Vol. 44, no 1, 45-58 p.Article in journal (Refereed)
    Abstract [en]

    Objective. Adverse outcome after CABG is closely related to postoperative heart failure precipitated by ischemia and myocardial infarction. Restrictive use of inotropes is therefore desirable. Patients with preoperative left ventricular dysfunction are a high-risk group in this respect. To reduce myocardial oxygen expenditure we evolved a metabolic strategy for perioperative care. Design. Observational study on 104 consecutive patients with severe left ventricular dysfunction undergoing CABG. The metabolic strategy implied physiological measures to minimize myocardial oxygen expenditure including restrictive use of inotropes and specific measures such as extended CPB and metabolic support to facilitate myocardial recovery. Hemodynamic state was primarily assessed by mixed venous oxygen saturation (SvO(2)). Follow-up averaged 9.7 +/- 1.4 years. Results. LVEF was 0.30 +/- 0.05 (range 0.20-0.37) and 3.5 +/- 1.3 vessels were bypassed. Inotropes were used in 6.7% for weaning from CPB. Increase of s-creatinine by andgt;= 50% compared to preoperative values was observed in 2.9%. Logistic EuroSCORE was 8.3% whereas observed 30-day mortality was 1.0%. Crude 5-year survival was 89.4%. Conclusions. The metabolic strategy allowed restrictive use of inotropes and was associated with encouraging long-term survival. Renal function was well preserved suggesting that SvO(2) served as an adequate marker of circulation. Randomized trials with metabolic support are warranted.

  • 49.
    Andersson, Anna
    et al.
    Linköping University, Department of Computer and Information Science, MDA. Linköping University, The Institute of Technology.
    Hallberg, Niklas
    Linköping University, Department of Computer and Information Science, MDA. Linköping University, The Institute of Technology.
    Timpka, Toomas
    Linköping University, Department of Medicine and Health Sciences. Linköping University, Faculty of Health Sciences.
    A Model for Interpreting Work and Information Management in Process-Oriented Healthcare Organisations2003In: International Journal of Medical Informatics, ISSN 1386-5056, Vol. 72, no 1-3, 47-56 p.Article in journal (Refereed)
    Abstract [en]

    Background: To increase productivity, management in healthcare organisations have introduced different types of process-oriented organisational configurations. Few studies have addressed clinical practice and information management in these settings. Methods: A case study was performed at a paediatric clinic. Data was collected from archives, through interviews, by participatory observation, and by performing a focus group session. The collected data was analysed using a qualitative and interpretative research strategy. Results: A model was developed of care practitioners’ daily work in process-oriented organisations. The model shows that clinical work was deeply integrated; the care activities were dependent on supply activities and tightly connected to management routines. Conclusion: The resulting model can be used to support development of health information system (HIS) embedded in process-oriented healthcare work.

  • 50.
    Lindström, Veronica
    et al.
    Linköping University, Department of Management and Engineering, Production Economics. Linköping University, The Institute of Technology.
    Habib, Sinan
    Torstensson, Simon
    A modified work process for manufacturing strategy formulation: A case study of a small industrial company in Sweden2014In: Proceedings of the 6th International Swedish Production Symposium 2014, 2014Conference paper (Refereed)
    Abstract [en]

    Manufacturing is a crucial part to organisational success in an industrial SME, and therefore manufacturing strategy formulation is of great importance for small businesses. Recent research suggests that there is a need to adapt frameworks and procedures for manufacturing strategy formulation to small- and medium sized companies. This study describes a modified work process, which was also tested for formulation of manufacturing strategy formulation in a small industrial company in Sweden.

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