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Ellabban, Mohamed A.ORCID iD iconorcid.org/0000-0003-3723-4604
Publications (2 of 2) Show all publications
Ellabban, M. A., Elmasry, M., Abdelrahman, I., Abdel Kader, G., Steinvall, I., Sjöberg, F., . . . Abdel Fattah, I. O. (2022). Experimental study of the effects of nitroglycerin, botulinum toxin A, and clopidogrel on bipedicled superficial inferior epigastric artery flap survival.. Scientific Reports, 12(1), Article ID 20891.
Open this publication in new window or tab >>Experimental study of the effects of nitroglycerin, botulinum toxin A, and clopidogrel on bipedicled superficial inferior epigastric artery flap survival.
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2022 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 12, no 1, article id 20891Article in journal (Refereed) Published
Abstract [en]

Beneficial effects could be achieved by various agents such as nitroglycerin, botulinum toxin A (BoTA), and clopidogrel to improve skin flap ischaemia and venous congestion injuries. Eighty rats were subjected to either arterial ischaemia or venous congestion and applied to a bipedicled U-shaped superficial inferior epigastric artery (SIEA) flap with the administration of nitroglycerin, BoTA, or clopidogrel treatments. After 7 days, all rats were sacrificed for flap evaluation. Necrotic area percentage was significantly minimized in flaps treated with clopidogrel (24.49%) versus the ischemic flaps (34.78%); while nitroglycerin (19.22%) versus flaps with venous congestion (43.26%). With ischemia, light and electron microscopic assessments revealed that nitroglycerin produced degeneration of keratinocytes and disorganization of collagen fibers. At the same time, with clopidogrel administration, there was an improvement in the integrity of these structures. With venous congestion, nitroglycerin and BoTA treatments mitigated the epidermal and dermal injury; and clopidogrel caused coagulative necrosis. There was a significant increase in tissue gene expression and serum levels of vascular endothelial growth factor (VEGF) in ischemic flaps with BoTA and clopidogrel, nitroglycerin, and BoTA clopidogrel in flaps with venous congestion. With the 3 treatment agents, gene expression levels of tumor necrosis factor-α (TNF-α) were up-regulated in the flaps with ischemia and venous congestion. With all treatment modalities, its serum levels were significantly increased in flaps with venous congestion and significantly decreased in ischemic flaps. Our analyses suggest that the best treatment option for ischemic flaps is clopidogrel, while for flaps with venous congestion are nitroglycerin and BoTA.

Place, publisher, year, edition, pages
Nature Publishing Group, 2022
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-192151 (URN)10.1038/s41598-022-24898-9 (DOI)000969757300018 ()36463303 (PubMedID)
Available from: 2023-03-06 Created: 2023-03-06 Last updated: 2024-01-10Bibliographically approved
Abdelrahman, I., Steinvall, I., Sjöberg, F., Ellabban, M. A., Zdolsek, J. & Elmasry, M. (2022). Pros and Cons of Early and Late Skin Grafting in Children with Burns—Evaluation of Common Concepts. European Burn Journal, 3(1), 180-187
Open this publication in new window or tab >>Pros and Cons of Early and Late Skin Grafting in Children with Burns—Evaluation of Common Concepts
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2022 (English)In: European Burn Journal, E-ISSN 2673-1991, Vol. 3, no 1, p. 180-187Article in journal (Refereed) Published
Abstract [en]

Background: There is no consensus regarding the timing of surgery in children with smallerburn size, specifically in deep dermal burns. Delayed surgery has risks in terms of infection anddelayed wound healing. Early surgery also risks the removal of potentially viable tissue. Our aim wasto investigate the effect of the timing of surgical intervention on the size of the area operated on andthe time to wound healing. Methods: A retrospective analysis for all children (<18 years) with burnsize <20% body surface area (BSA%) during 2009–2020 who were operated on with a split-thicknessskin graft. The patients were grouped by the timing of the first skin graft operation: early = operatedon within 14 days of injury; delayed = operated on more than two weeks after injury. Results: A totalof 84 patients were included in the study, 43 who had an early operation and 41 who had a delayedoperation. There were no differences between the groups regarding burn size, or whether the burnswere superficial or deep. The mean duration of healing time was seven days longer in the group withdelayed operation (p = 0.001). The area operated on was somewhat larger (not significantly so) in thegroup who had early operation. Nine children had two skin graft operations, eight in the early groupand one in the delayed group (p = 0.03). Conclusion: The patients who were operated on early hadthe advantage of a shorter healing time, but there was a higher rate of complementary operationsand a tendency towards a larger burn excision.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
burns; children; healing time; burn surgery; skin graft
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-183535 (URN)10.3390/ebj3010015 (DOI)
Available from: 2022-03-17 Created: 2022-03-17 Last updated: 2024-06-24Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-3723-4604

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