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Ståhl, S., af Geijerstam, P., Wijkman, M., Johansson, M. M., Chalmers, J., Nägga, K. & Rådholm, K. (2025). Hypertension and orthostatic hypertension in 85-year-olds and associations with mortality and cognitive decline in a longitudinal cohort study. Scientific Reports, 15(1), Article ID 10529.
Open this publication in new window or tab >>Hypertension and orthostatic hypertension in 85-year-olds and associations with mortality and cognitive decline in a longitudinal cohort study
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2025 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 15, no 1, article id 10529Article in journal (Refereed) Published
Abstract [en]

Hypertension is a risk factor for cardiovascular disease, but the evidence for treatment and blood pressure (BP) targets in the elderly is less robust. Orthostatic hypertension is a potential risk factor for cardiovascular mortality and cognitive decline. All 85-years-olds in Linköping municipality, Sweden, were invited to a prospective birth cohort study including questionnaires, cognitive testing and physical examinations, including supine and orthostatic BP measurements. Logistic regression and Cox proportional hazard models were used to assess the impact of baseline supine and orthostatic BP on cognitive decline and all-cause mortality after 5- and 7.2 years respectively. Of 650 invited 85-year-olds, 322 were included. During follow-up, 190 persons died, and 28 persons developed cognitive decline. Neither elevated supine BP nor orthostatic hypertension were associated with cognitive decline. After adjustments, elevated supine BP was not associated with mortality in all participants, but was associated with lower all-cause mortality in participants with previously diagnosed hypertension, HR 0.59 (95% CI 0.41–0.85). Orthostatic hypertension was not associated with all-cause mortality, HR 0.56 (95% CI 0.26–1.22) after multiple adjustments. In 85-year-olds with known hypertension, elevated supine BP was associated with lower all-cause mortality. Orthostatic hypertension was not associated with cognitive decline but trended towards a lower all-cause mortality.

Place, publisher, year, edition, pages
Springer Nature, 2025
National Category
Cardiology and Cardiovascular Disease Geriatrics
Identifiers
urn:nbn:se:liu:diva-212633 (URN)10.1038/s41598-025-94913-2 (DOI)001455386100041 ()40148538 (PubMedID)2-s2.0-105001102009 (Scopus ID)
Funder
Linköpings universitet
Note

Funding Agencies|Swedish government [ROE-375501]; County councils (ALF) [ROE-375501]; Medical Research Council of Southeast Sweden [FORSS-107371]; Region OEstergoetland

Available from: 2025-03-27 Created: 2025-03-27 Last updated: 2025-05-21
af Geijerstam, P., Harris, K., Johansson, M. M., Chalmers, J., Nägga, K. & Rådholm, K. (2025). Orthostatic Hypotension and Cognitive Function in Individuals 85 Years of Age: A Longitudinal Cohort Study in Sweden. Aging and Disease, 16(1), 469-478
Open this publication in new window or tab >>Orthostatic Hypotension and Cognitive Function in Individuals 85 Years of Age: A Longitudinal Cohort Study in Sweden
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2025 (English)In: Aging and Disease, ISSN 2152-5250, Vol. 16, no 1, p. 469-478Article in journal (Refereed) Published
Abstract [en]

Background: Orthostatic hypotension (OH) is more common in the elderly, and associated with increased mortality. However, its implications in 85-year-olds are not known.

Methods: In the prospective observational cohort study Elderly in Linköping Screening Assessment (ELSA 85), 496 individuals in Linköping, Sweden, were followed from age 85 years with cognitive assessments. Blood pressure (BP) was measured supine and after 1, 3, 5, and 10 minutes of standing. Participants with a BP fall of ≥20 mmHg systolic or ≥10 mmHg diastolic after 1 or 3 minutes were classified as classical continuous or classical transient OH depending on whether the BP fall was sustained or not, at subsequent measurements. Those with a BP fall of the same magnitude, but only after 5 or 10 minutes were classified as delayed OH.

Results: Of participants, 329 took part in BP measurements and were included. Of these, 156 (47.4%) had classical OH (113 [34.3%] continuous classical, 38 [11.6%] transient classical), and 15 (4.6%) had delayed OH. Cognitive assessments were not markedly different between groups. After 8.6 years, 195 (59.3%) of the participants had died, and delayed vs no OH was associated with twice the risk of all-cause mortality, HR 2.15 (95% CI 1.12-4.12). Transient classical OH was associated with reduced mortality, HR 0.58 (95% CI 0.33-0.99), but not after multiple adjustments, and continuous classical OH was not associated with mortality.

Conclusion: OH may have different implications for morbidity and mortality in 85-year-olds compared with younger populations.

Place, publisher, year, edition, pages
Fort Wortht, TX, United States: Buck Institute for Age Research, 2025
Keywords
Orthostatic hypotension, mortality, cognitive decline
National Category
Geriatrics
Identifiers
urn:nbn:se:liu:diva-201163 (URN)10.14336/ad.2024.0205 (DOI)001171242300001 ()38421828 (PubMedID)2-s2.0-85211072907 (Scopus ID)
Note

Funding: Swedish National Research School in General Practice; George Institute for Global Health; National Research School in General Practice; Swedish Society of Medicine, The Strategic Research Network in Circulation and Metabolism at Linkping University; Swedish Society for Medical Research; Health Research Council in the South-East of Sweden [FORSS-8888, FORSS-11636, FORSS-31811, LIO-11877, LIO-31321, LIO-79951]

Available from: 2024-02-25 Created: 2024-02-25 Last updated: 2025-04-23Bibliographically approved
Dong, H.-J., Peolsson, A. & Johansson, M. M. (2024). Effects of proactive healthcare on pain, physical and activities of daily living functioning in vulnerable older adults with chronic pain: a pragmatic clinical trial with one- and two-year follow-up. European Geriatric Medicine, 15(3), 709-718
Open this publication in new window or tab >>Effects of proactive healthcare on pain, physical and activities of daily living functioning in vulnerable older adults with chronic pain: a pragmatic clinical trial with one- and two-year follow-up
2024 (English)In: European Geriatric Medicine, ISSN 1878-7649, E-ISSN 1878-7657, Vol. 15, no 3, p. 709-718Article in journal (Refereed) Published
Abstract [en]

Purpose To investigate the changes in pain, physical and activities of daily living (ADL) functioning in vulnerable older adults with chronic pain after proactive primary care intervention. Methods This study was embedded in a prospective, pragmatic, matched-control multicenter trial at 19 primary care practices in Sweden, with proactive medical and social care (Intervention Group, IG, n = 134) in comparison with usual care (Control Group, CG, n = 121). Patients with chronic pain, defined as pain experienced longer than 3 months, were included in this subgroup analysis. Data on pain aspects, physical and ADL functioning were collected in the questionnaires at baseline, one- and two-year follow-up (FU-1 and FU-2). Data on prescribed pain medications was collected by local health authorities. Results Mean age was 83.0 +/- 4.7 years with almost equal representation of both genders. From baseline until FU-2, there were no significant within-group or between-group changes in pain intensity. Small adjustments of pain medication prescriptions were made in both groups. Compared to FU-1, the functional changes were more measurable at FU-2 as fewer participants had impaired physical functioning in IG (48.4%) in comparison to CG (62.6%, p = 0.027, Effect Size phi = 0.14). Higher scores of ADL-staircase (more dependent) were found in both groups (p < 0.01, Effect Size r = 0.24 in CG and r = 0.16 in IG). Conclusion Vulnerable older adults with chronic pain seemed to remain physical and ADL functioning after proactive primary care intervention, but they may need tailored strategies of pain management to improve therapeutic effects.

Place, publisher, year, edition, pages
SPRINGER, 2024
Keywords
Proactive healthcare; Chronic pain; Activities of daily living (ADL); Physical functioning; Vulnerable; Aging
National Category
Geriatrics
Identifiers
urn:nbn:se:liu:diva-202290 (URN)10.1007/s41999-024-00952-9 (DOI)001176829100002 ()38446408 (PubMedID)2-s2.0-85186912748 (Scopus ID)
Note

Funding Agencies|Health Care and Welfare

Available from: 2024-04-09 Created: 2024-04-09 Last updated: 2025-02-25Bibliographically approved
Kastbom, L., Johansson, M. M., Sverker, A. M. & Segernäs Kvitting, A. (2024). Thanks for hearing me: key elements of primary care according to older patients. Scandinavian Journal of Primary Health Care, 42(2), 304-315
Open this publication in new window or tab >>Thanks for hearing me: key elements of primary care according to older patients
2024 (English)In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 42, no 2, p. 304-315Article in journal (Refereed) Published
Abstract [en]

Objective: When organising healthcare and planning for research to improve healthcare, it is important to include the patients' own perceptions. Therefore, the aim was to explore older patients' views on what is important concerning their current care and possible future interventions in a primary care setting. Design: A qualitative design with individual interviews was used. Analysis through latent content analysis. Setting: Seven Swedish primary care centres. Subjects: Patients (n 30) aged >75 years, connected to elder care teams in primary healthcare. Results: Three categories, consisting of 14 sub-categories in total, were found, namely: Care characterised by easy access, continuity and engaged staff builds security; Everyday life and Plans in late life. The overarching latent theme Person-centred care with easy access, continuity and engaged staff gave a deeper meaning to the content of the categories and sub-categories. Conclusion: It is important to organise primary care for older people through conditions which meet up with their specific needs. Our study highlights the importance of elder care teams facilitating the contact with healthcare, ensuring continuity and creating conditions for a person-centred care. There were variations regarding preferences about training and different views on conversations about end-of-life, which strengthens the need for individualisation and personal knowledge. This study also exemplifies qualitative individual interviews as an approach to reach older people to be part of a study design and give input to an upcoming research intervention, as the interviews contribute with important information of value in the planning of the Swedish intervention trial Secure and Focused Primary Care for Older pEople (SAFE).

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD, 2024
Keywords
Older adults; patient-centered care; patient participation; primary health care; qualitative research
National Category
Nursing
Identifiers
urn:nbn:se:liu:diva-201463 (URN)10.1080/02813432.2024.2317833 (DOI)001173737500001 ()38380956 (PubMedID)2-s2.0-85185499136 (Scopus ID)
Note

Funding Agencies|ALF grants

Available from: 2024-03-11 Created: 2024-03-11 Last updated: 2025-08-14Bibliographically approved
Laitalainen Törnudd, M., Peolsson, A. & Johansson, M. M. (2024). The perceptions of nurses and physicians in primary care of rehabilitation for frail older adults. Clinical Rehabilitation, 38(9), 1276-1286
Open this publication in new window or tab >>The perceptions of nurses and physicians in primary care of rehabilitation for frail older adults
2024 (English)In: Clinical Rehabilitation, ISSN 0269-2155, E-ISSN 1477-0873, Vol. 38, no 9, p. 1276-1286Article in journal (Refereed) Published
Abstract [en]

Objectives To investigate the perceptions of primary care nurses and physicians of the potential contributions of physiotherapists (PTs) and occupational therapists (OTs) in the treatment of frail older persons, as well as the obstacles to, and opportunities for, collaboration.Design A qualitative study.Participants and setting Nurses (n = 9) and physicians (n = 8) in primary care in the county council [14 women (82%)] with experience working with older people.Method Interview study conducted with a semi-structured interview guide. Analyses were carried out with content analysis with an inductive approach.Results The analysis resulted in six categories: knowledge of physiotherapy and occupational therapy interventions; what triggers the need for physiotherapy and occupational therapy?; the availability of rehabilitation interventions; teamwork opportunities and difficulties; motivating the patient; the site of the rehabilitation.Conclusions Close and clear collaboration between nurses and physicians and PTs and OTs is an important factor in ensuring that rehabilitation interventions provide the greatest possible benefit to the patient. Improving communication between different healthcare providers and clarifying the contact routes is a prerequisite for patients to be able to get the rehabilitation they need. More research is needed to determine the best approach to achieving this goal.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD, 2024
Keywords
Frail elderly; occupational therapy; patient care team; physical therapy specialty; primary care
National Category
Nursing
Identifiers
urn:nbn:se:liu:diva-204296 (URN)10.1177/02692155241258286 (DOI)001237441200001 ()38825588 (PubMedID)
Note

Funding Agencies|Linkopings Universitet, Region Ostergotland [2016186-14]

Available from: 2024-06-10 Created: 2024-06-10 Last updated: 2024-12-12Bibliographically approved
Storm, E., Bendelin, N., Bergström Wessman, K., Johansson, M. M., Björk, M. & Dong, H.-J. (2023). Lifestyle changes are burdensome with my body broken by pain and obesity: patients perspectives after pain rehabilitation. BMC Musculoskeletal Disorders, 24(1), Article ID 840.
Open this publication in new window or tab >>Lifestyle changes are burdensome with my body broken by pain and obesity: patients perspectives after pain rehabilitation
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2023 (English)In: BMC Musculoskeletal Disorders, E-ISSN 1471-2474, Vol. 24, no 1, article id 840Article in journal (Refereed) Published
Abstract [en]

Background Despite the existing evidence regarding the interrelated relationship between pain and obesity, knowledge about patients perspectives of this relationship is scarce, especially from patients with chronic pain and obesity after completing Interdisciplinary Pain Rehabilitation Program (IPRP). Aims This qualitative study expands the understanding of patients perspectives on how chronic pain and obesity influence each other and how the two conditions affect the ability to make lifestyle changes. Method A purposive sample of patients with Body Mass Index (BMI) >= 30 kg/m(2) and who had completed an IPRP were recruited for individual semi-structured interviews. The transcribed interviews were analysed using latent content analysis and a pattern of theme and categories was constructed based on the participants perspectives. Results Sixteen patients (aged 28-63 years, 11 female, BMI 30-43 kg/m(2)) shared their experiences of chronic pain, obesity and lifestyle changes after IPRP. The analysis revealed one overall theme (lifestyle changes are burdensome with a body broken by both pain and obesity) and four categories (pain disturbing days and nights worsens weight control, pain-related stress makes lifestyle changes harder, a painful and obese body intertwined with negative emotions and the overlooked impact of obesity on chronic pain). Most participants perceived that their pain negatively impacted their obesity, but they were uncertain whether their obesity negatively impacted their pain. Nevertheless, the participants desired and struggled to make lifestyle changes. Conclusion After IPRP, patients with chronic pain and obesity perceived difficulties with self-management and struggles with lifestyle changes. They experienced a combined burden of the two conditions. Their perspective on the unilateral relationship between pain and obesity differed from the existing evidence. Future tailored IPRPs should integrate nutritional interventions and address the knowledge gaps as well.

Place, publisher, year, edition, pages
BMC, 2023
Keywords
Chronic pain; Obesity; Lifestyle; Interdisciplinary Pain Rehabilitation Program (IPRP); Rehabilitation
National Category
Physiotherapy
Identifiers
urn:nbn:se:liu:diva-199114 (URN)10.1186/s12891-023-06961-2 (DOI)001088901500001 ()37880642 (PubMedID)
Note

Funding Agencies|The authors thank all the patients who considered and shared their personal experiences. We would like to give our thanks to research assistants Annika Kallin, Pernilla Olsson, Frida Strand, and Lena Connysson for participant coordination, transcription, and extraction of the quantitative data from SQRP.

Available from: 2023-11-13 Created: 2023-11-13 Last updated: 2025-02-11
Nelsson, A., Johansson, M. M. & Korhonen, L. (2022). Anmälan om oro att ett barn far illa. Svensk psykiatri (3)
Open this publication in new window or tab >>Anmälan om oro att ett barn far illa
2022 (Swedish)In: Svensk psykiatri, no 3Article in journal (Other academic) Published
Abstract [sv]

Socialtjänsten har en viktig roll för att barn och unga ska kunna växa upp under de trygga förhållanden som de har rätt till. Detta förutsätter att socialtjänsten får kännedom om barn som kan behöva skydd och hjälp i form av en orosanmälan. Man kan även behöva göra polisanmälan vid till exempel allvarliga brott.

Place, publisher, year, edition, pages
Sverige: Svenska Psykiatriska Föreningen, 2022
National Category
Social Work
Identifiers
urn:nbn:se:liu:diva-189905 (URN)
Available from: 2022-11-13 Created: 2022-11-13 Last updated: 2023-12-28Bibliographically approved
Kammerlind, A.-S., Peolsson, A. & Johansson, M. M. (2022). Dizziness in older persons at high risk of future hospitalization: prevalence, differences between those with and without dizziness, and effect of a proactive primary care intervention. BMC Geriatrics, 22(1), Article ID 315.
Open this publication in new window or tab >>Dizziness in older persons at high risk of future hospitalization: prevalence, differences between those with and without dizziness, and effect of a proactive primary care intervention
2022 (English)In: BMC Geriatrics, E-ISSN 1471-2318, Vol. 22, no 1, article id 315Article in journal (Refereed) Published
Abstract [en]

Background: Dizziness is a common reason for seeking care, and frequently affects older persons. The aims were to determine the prevalence of dizziness in older persons at high risk of hospitalization, to compare subjects with and without dizziness, and to examine the effects on dizziness of a proactive primary care intervention in comparison with conventional care after one year.

Methods: Data were derived from a prospective multicentre clinical trial in persons aged 75 and older and at high risk of hospitalization. A baseline questionnaire included demographic data, use of aids, questions about everyday physical activity and exercise, pain (intensity, frequency, and duration), activities of daily living measured using the ADL Staircase, and health-related quality of life measured using the EQ-5D-3L vertical visual analogue scale. Both at baseline and after one year, subjects were asked about dizziness, and those with dizziness answered the Dizziness Handicap Inventory - Screening version. Subjects in the intervention group were evaluated by a primary care team and when needed proactive care plans were established. Groups were compared using the Mann Whitney U-test or chi-squared test.

Results: Of the 779 subjects, 493 (63%) experienced dizziness. Persons with dizziness differed regarding sex, homecare service, aids, activities of daily living, health-related quality of life, physical activity, and pain. The intervention did not significantly reduce the level of dizziness.

Conclusions: Dizziness is common in vulnerable older persons, and individuals with dizziness differ in several respects. Further studies are needed employing more dizziness-specific assessment and individually tailored interventions.

Place, publisher, year, edition, pages
London, United Kingdom: BioMed Central, 2022
Keywords
Aged; Dizziness; Geriatric assessment; Hospitalization; Prevalence; Primary health care
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-184549 (URN)10.1186/s12877-022-02910-1 (DOI)000779976900003 ()35399055 (PubMedID)2-s2.0-85127874725 (Scopus ID)
Note

Funding Agencies: County Council of Östergötland; Linköping University [2016186-14]

Available from: 2022-04-26 Created: 2022-04-26 Last updated: 2024-07-04Bibliographically approved
Segernäs Kvitting, A., Johansson, M. M. & Marcusson, J. (2019). Accuracy of the Cognitive Assessment Battery in a Primary Care Population. Dementia and Geriatric Cognitive Disorders Extra, 9(2), 294-301
Open this publication in new window or tab >>Accuracy of the Cognitive Assessment Battery in a Primary Care Population
2019 (English)In: Dementia and Geriatric Cognitive Disorders Extra, E-ISSN 1664-5464, Vol. 9, no 2, p. 294-301Article in journal (Refereed) Published
Abstract [en]

Background: There are several cognitive assessment tools used in primary care, e.g., the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment. The Cognitive Assessment Battery (CAB) was introduced as a sensitive tool to detect cognitive decline in primary care. However, primary care validation is lacking. Therefore, we investigated the accuracy of the CAB in a primary care population. 

Objective: To investigate the accuracy of the CAB in a primary care population. 

Methods: Data from 46 individuals with cognitive impairment and 33 individuals who visited the primary care with somatic noncognitive symptoms were analyzed. They were investigated with the MMSE, the CAB, and a battery of neuropsychological tests; they also underwent consultation with a geriatric specialist. The accuracy of the CAB was assessed using c-statistics and the area under the receiver operating characteristic curve (AUC) was used to quantify the binary outcomes (“no cognitive impairment” or “cognitive impairment”).

Results: The “cognitive impairment” group was significantly different from the unimpaired group for all the subtests of the CAB. When accuracy was based on binary significant reduction or not in one or several domains of the CAB, the AUC varied between 0.685 and 0.772. However, when a summation or logistic regression of several subcategories was performed, using the numerical values for each subcategory, the AUC was >0.9. For comparison, the AUC for the MMSE was 0.849.

Conclusions: The accuracy of the CAB in a primary care population is poor to good when using binary cutoffs. Accuracy can be improved to high when using a summation or logistic regression of the numerical data of the subcategories. Considering CAB time, lack of adequate age norms, and a good accuracy for the MMSE, implementation of the CAB in primary care is not recommended at present based on the results of this study.

Place, publisher, year, edition, pages
S. Karger, 2019
Keywords
Primary care cognitive tests, Cognitive Assessment Battery, Cognitive assessment tools
National Category
Neurology Geriatrics
Identifiers
urn:nbn:se:liu:diva-160370 (URN)10.1159/000501365 (DOI)000496485700009 ()2-s2.0-85071030454 (Scopus ID)
Available from: 2019-09-20 Created: 2019-09-20 Last updated: 2023-03-20Bibliographically approved
Johansson, M. M., Marcusson, J. & Wressle, E. (2019). Maintaining health-related quality of life from 85 to 93 years of age despite decreased functional ability. British Journal of Occupational Therapy, 82(6), 348-356
Open this publication in new window or tab >>Maintaining health-related quality of life from 85 to 93 years of age despite decreased functional ability
2019 (English)In: British Journal of Occupational Therapy, ISSN 0308-0226, E-ISSN 1477-6006, Vol. 82, no 6, p. 348-356Article in journal (Refereed) Published
Abstract [en]

Introduction

The ‘oldest-old’ is the most rapidly growing age group in Sweden and in the western world. This group is known to be at great risk of increased functional dependency and the need for help in their daily lives. The aim of this research was to examine how the oldest-old change over time regarding health-related quality of life, cognition, depression and ability to perform activities of daily living and investigate what factors explain health-related quality of life at age 85 and 93 years.

Methods

In this study, 60 individuals from the Swedish Elderly in Linköping Screening Assessment study were followed from age 85 to 93 years. Measurements used were EQ-5D, Geriatric Depression Scale, Mini Mental State Examination and ability to perform activities of daily living. Nonparametric statistics and regression analyses were used.

Results

Although the individuals had increased mobility problems, decreased ability to manage activities of daily living, and thus had increased need of assistance, they scored their health-related quality of life at age 93 years at almost the same level as at age 85 years. No depression and low dependence in activities of daily living speaks in favour of higher health-related quality of life.

Conclusions

Health-related quality of life can be maintained during ageing despite decreased functional ability and increased need of assistance in daily life.

Place, publisher, year, edition, pages
Sage Publications, 2019
Keywords
Health-related quality of life; daily living; elderly; occupational therapy
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-158562 (URN)10.1177/0308022619830261 (DOI)000469876400004 ()2-s2.0-85062771149 (Scopus ID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden [FORSS-8888, FORSS-11636, FORSS-31811]; County Council of Ostergotland [LIO-11877, LIO-31321, LIO-79951]; Janne Elgqvist Family Foundation

Available from: 2019-07-03 Created: 2019-07-03 Last updated: 2019-11-27Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-4166-7269

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