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Lampi, Maria
Publications (4 of 4) Show all publications
Muhrbeck, M., Wladis, A., Lampi, M., Andersson, P. & Junker, J. (2022). Efficacy of topical honey compared to systemic gentamicin for treatment of infected war wounds in a porcine model: A non-inferiority experimental pilot study. Injury, 53(2), 381-392
Open this publication in new window or tab >>Efficacy of topical honey compared to systemic gentamicin for treatment of infected war wounds in a porcine model: A non-inferiority experimental pilot study
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2022 (English)In: Injury, ISSN 0020-1383, E-ISSN 1879-0267, Vol. 53, no 2, p. 381-392Article in journal (Refereed) Published
Abstract [en]

Background: In armed conflicts, infected wounds constitute a large portion of the surgical workload. Treatment consists of debridements, change of dressings, and antibiotics. Many surgeons advocate for the use of honey as an adjunct with the rationale that honey has bactericidal and hyperosmotic properties. However, according to a Cochrane review from 2015 there is insufficient data to draw any conclusions regarding the efficacy of honey in treatment of wounds. We, therefore, decided to evaluate if honey is non-inferior to gentamicin in the treatment of infected wounds in a highly translatable porcine wound model. Material and methods: 50 standardized wounds on two pigs were infected with S. aureus and separately treated with either topically applied Manuka honey or intramuscular gentamicin for eight days. Treatment efficacy was evaluated with quantitative cultures, wound area measurements, histological, immunohistochemical assays, and inflammatory response. Results: Topically applied Manuka honey did not reduce bacterial count or wound area for the duration of treatment. Intramuscular gentamicin initially reduced bacterial count (geometric mean 5.59*,0.37 - 4.27 *,0.80 log10 (GSD) CFU/g), but this was not sustained for the duration of the treatment. However, wound area was significantly reduced with intramuscular gentamicin at the end of treatment (mean 112.8 +/- 30.0-67.7 +/- 13.2 (SD) mm(2)). ANOVA-analysis demonstrated no variation in bacterial count for the two treatments but significant variation in wound area (p = 0.0001). The inflammatory response was more persistent in the pig with wounds treated with topically applied Manuka honey than in the pig treated with intramuscular gentamicin. Conclusion: At the end of treatment S. aureus count was the same with topically applied Manuka honey and intramuscular gentamicin. The wound area was unchanged with topically applied Manuka honey and decreased with intramuscular gentamicin. Topically applied Manuka honey could consequently be non inferior to intramuscular gentamicin in reducing S. aureus colonization on the wounds surface, but not in reducing wound size. The use of Manuka honey dressings to prevent further progression of a wound infection may therefore be of value in armed conflicts, where definite care is not immediately available.

Place, publisher, year, edition, pages
Elsevier, 2022
Keywords
Developing countries, Armed conflicts, Penetrating wounds, Wound infection, Honey, Antibiotics, Experimental animal model
National Category
Infectious Medicine
Identifiers
urn:nbn:se:liu:diva-180709 (URN)10.1016/j.injury.2021.10.019 (DOI)000749798400024 ()34756413 (PubMedID)
Note

Funding agencies: Kamprad Family Foundation [20170287]; Swedish government [LIO-700121]; county councils, the ALF-agreement [LIO-700121]

Available from: 2021-11-01 Created: 2021-11-01 Last updated: 2022-05-19Bibliographically approved
Prytz, E., Åkerstedt, Z., Lidestam, B., Lampi, M. & Jonson, C.-O. (2019). A pilot investigation of the effect of transport-related factors on care quality in a moving ambulance. Paper presented at 21st WADEM congress on disaster and emergency medicine, Brisbane, Australia, May 7-10, 2019. . Prehospital and Disaster Medicine, 34(1), 158-158
Open this publication in new window or tab >>A pilot investigation of the effect of transport-related factors on care quality in a moving ambulance
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2019 (English)In: Prehospital and Disaster Medicine, ISSN 1049-023X, E-ISSN 1945-1938, Vol. 34, no 1, p. 158-158Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Introduction:

Providing patient care in a moving ambulance can be difficult due to various transport-related factors, (e.g., accelerations, lateral forces, and noise). Previous research has primarily focused on cardiopulmonary resuscitation (CPR) performance effects but has neglected to investigate other care interventions.

Aim:

To test a range of different care interventions during different driving scenarios.

Methods:

A workshop with ambulance practitioners was held to create a list of care interventions to be tested. Two ambulance practitioners were recruited to drive an ambulance on a closed test-track while performing care interventions on simulation models. Three driving scenarios of differing difficulty were used. Main outcome measures were estimates of workload using the NASA Task Load Index (TLX) and task difficulty. G-forces and video-data were also collected.

Results:

Estimated workload increased overall as the difficulty of the driving scenario increased, as did task difficulty estimates. However, some care scenarios and interventions were affected less. For example, placing intravenous access increased greatly in difficulty, whereas saturation and blood pressure measurements had more modest increases. TLX scores showed that the primarily estimated physical workload and effort that increased, but also mental and temporal demands for some care scenarios. The more difficult driving scenarios primarily increased the variability of measured G-forces but not necessarily the overall driving speed, indicating that force variability is an important factor to study further.

Discussion:

The study was intended as an initial pilot test of a wide range of care interventions. It will serve as input to future, larger studies of specific interventions and transport-related factors. Overall, this small pilot indicates that more interventions than only CPR should be studied in moving ambulances to investigate potential performance effects. This is important for traffic, patient, and work safety for ambulance workers and patients.

Place, publisher, year, edition, pages
Cambridge University Press, 2019
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:liu:diva-169410 (URN)10.1017/S1049023X19003571 (DOI)
Conference
21st WADEM congress on disaster and emergency medicine, Brisbane, Australia, May 7-10, 2019. 
Available from: 2020-09-14 Created: 2020-09-14 Last updated: 2024-05-17Bibliographically approved
Berggren, P., Svensson, F., Lampi, M. & Prytz, E. (2018). Battlefield trauma care. In: Proceedings of the Human Factors and Ergonomics Society 62nd Annual Meeting: . Paper presented at The Human Factors and Ergonomics Society 62nd Annual Meeting. Philadelphia, PA, October 1-5, 2018 (pp. 634-638). Sage Publications, 62, Article ID 1.
Open this publication in new window or tab >>Battlefield trauma care
2018 (English)In: Proceedings of the Human Factors and Ergonomics Society 62nd Annual Meeting, Sage Publications, 2018, Vol. 62, p. 634-638, article id 1Conference paper, Published paper (Refereed)
Abstract [en]

Introduction: Rapid and structured medical care is important to increase wounded patients’ chances of survival in modern warfare. This requires a functioning medical chain. 

Aim: The aim of this study was to expand the knowledge of how the battlefield trauma care affects patient outcome in situations with a large number of casualties in the Swedish armed forces. 

Methods: An empirical study with a convergent parallel mixed methods design, which included observations and semi-structured interviews. 

Results: The results show that the trauma care performed at Role 1-units functioned well. The most prominent issue discovered was deficiency in transportation resources for medical evacuation throughout the entire medical chain. 

Conclusion: Despite that the trauma care performed at Role 1-units functions well, casualties are at risk for preventable complications or death. Improved transportation logistics are required to improve the medical capabilities of the Swedish armed forces.

Place, publisher, year, edition, pages
Sage Publications, 2018
Series
Proceedings of the Human Factors and Ergonomics Society 62nd Annual Meeting, ISSN 2169-5067, E-ISSN 1071-1813
Keywords
Combat casualty, Field resuscitation, Medical evacuation, Prehospital, Trauma
National Category
Health Sciences
Identifiers
urn:nbn:se:liu:diva-169416 (URN)10.1177/1541931218621145 (DOI)
Conference
The Human Factors and Ergonomics Society 62nd Annual Meeting. Philadelphia, PA, October 1-5, 2018
Available from: 2020-09-14 Created: 2020-09-14 Last updated: 2021-01-29Bibliographically approved
Lampi, M., Junker, J., Tabu, J. S., Berggren, P., Jonson, C.-O. & Wladis, A. (2018). Potential benefits of triage for the trauma patient in a Kenyan emergency department. BMC Emergency Medicine, 18, Article ID 49.
Open this publication in new window or tab >>Potential benefits of triage for the trauma patient in a Kenyan emergency department
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2018 (English)In: BMC Emergency Medicine, E-ISSN 1471-227X, Vol. 18, article id 49Article in journal (Refereed) Published
Abstract [en]

Background

Improved trauma management can reduce the time between injury and medical interventions, thus decreasing morbidity and mortality. Triage at the emergency department is essential to ensure prioritization and timely assessment of injured patients. The aim of the present study was to investigate how a lack of formal triage system impacts timely intervention and mortality in a sub-Saharan referral hospital. Further, the study attempts to assess potential benefits of triage towards efficient management of trauma patients in one middle income country.

Methods

A prospective descriptive study was conducted. Adult trauma patients admitted to the emergency department during an 8-month period at Moi Teaching and Referral Hospital in Eldoret, Kenya, were included. Mode of arrival and vital parameters were registered. Variables included in the analysis were Injury Severity Score, time before physician’s assessment, length of hospital stay, and mortality. The patients were retrospectively categorized according to the Rapid Emergency Triage and Treatment System (RETTS) from patient records.

Results

A total of 571 patients were analyzed, with a mean Injury Severity Score of 12.2 (SD 7.7) with a mean length of stay of 11.6 (SD 18.3) days. The mortality rate was 1.8%. The results obtained in this study illustrate that trauma patients admitted to the emergency department at Eldoret are not assessed in a timely fashion, and the time frame recommendations postulated by RETTS are not adhered to. Assessment of patients according to the triage algorithm used revealed a significantly higher average Injury Severity Score in the red category than in the other color categories.

Conclusion

The results from this study clearly illustrate a lack of correct prioritization of patients in relation to the need for timely assessment. This is further demonstrated by the retrospective triage classification of patients, which identified patients with high ISS as in urgent need of care. Since no significant difference in to time to assessment regardless of injury severity was observed, the need for a well-functioning triage system is apparent.

Place, publisher, year, edition, pages
Springer, 2018
Keywords
Triage, Trauma, Emergency department
National Category
Anesthesiology and Intensive Care
Research subject
Disaster Medicine
Identifiers
urn:nbn:se:liu:diva-153305 (URN)10.1186/s12873-018-0200-7 (DOI)000452637100002 ()30497397 (PubMedID)2-s2.0-85057551142 (Scopus ID)
Note

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Available from: 2018-12-11 Created: 2018-12-11 Last updated: 2024-07-04Bibliographically approved
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