The information system (IS) community has long debated the nature of ISs without reaching closure (e.g. Baskerville, 2012). This uncertainty may have contributed to spectacular IT project failures (e.g. Dalcher, 2003). Thus, there is a need to reconceptualize ISs from new and innovative positions. At previous NeuroIS retreats (2011, 2012), I have discussed the construct of activity modalities as a conceptual link between the brain and human action (Taxén, 2009). In this contribution I will pursue this line of inquiry into the IS area.