liu.seSearch for publications in DiVA
Operational message
There are currently operational disruptions. Troubleshooting is in progress.
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Development of integrated electrochemical–quartz crystal microbalance biosensor arrays: towards ultrasensitive, multiplexed and rapid point-of-care dengue detection
International Islamic University Malaysia, Kuala Lumpur, Malaysia.
International Islamic University Malaysia, Kuala Lumpur, Malaysia.
International Islamic University Malaysia, Kuala Lumpur, Malaysia.
International Islamic University Malaysia, Kuala Lumpur, Malaysia.
Show others and affiliations
2019 (English)In: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - BIODEVICES 2019 / [ed] Ana Roque; Ana Fred; Hugo Gamboa, SciTePress, 2019, Vol. 1, p. 220-227Conference paper, Published paper (Refereed)
Abstract [en]

Dengue is an infectious mosquito-borne viral disease that affects approximately 50 million people annually worldwide and is prevalent mostly in the tropics. Severe cases of dengue can be fatal, making early detection and fast diagnosis crucial towards improving patient care and survival rates. Currently, early detection can be achieved through detection of NS1 protein, using ELISA technique. Unfortunately, ELISA is an expensive method, making it unsuitable as a screening technique, especially in low-resource settings. In this work, we present a prototype device and its early validation studies, of an integrated electrochemical and mass-sensor for dengue NS1 antigen. The sensor is connected to open source mass-sensing software and hardware, OpenQCM which makes it easily portable. Having dual-measurement capabilities (mass and impedance) increases the sensitivity of the sensor. Preliminary studies suggest that the prototype could achieve ultralow limit of detection as low as 10 ng mL-1, dual-sensing cross-validation capability, portable size, time of less than 30 minutes, and parallelization of multiple assays. This work could lead to early and accurate dengue detection in routine point-of-care settings.

Place, publisher, year, edition, pages
SciTePress, 2019. Vol. 1, p. 220-227
Series
Biostec, ISSN 2184-4305
Keywords [en]
Dengue; Biosensor; Sensor Arrays; Integrated Electrochemical-Quartz Crystal Microbalance; Point-of-Care Diagnostics
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:liu:diva-165698DOI: 10.5220/0007523802200227ISI: 000671845700026Scopus ID: 2-s2.0-85064638905ISBN: 9789897583537 (print)OAI: oai:DiVA.org:liu-165698DiVA, id: diva2:1430062
Conference
BioDevices, February 22-24, 2019, Prague, Czech Republic
Available from: 2020-05-13 Created: 2020-05-13 Last updated: 2024-09-01Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopus

Authority records

Mak, Wing Cheung

Search in DiVA

By author/editor
Mak, Wing Cheung
By organisation
Sensor and Actuator SystemsFaculty of Science & Engineering
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
isbn
urn-nbn

Altmetric score

doi
isbn
urn-nbn
Total: 106 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf