Constraint satisfaction problems (CSPs) are combinatorial problems with strong ties to universal algebra and clone theory. The recently proved CSP dichotomy theorem states that finite-domain CSPs are always either tractable or NP-complete. However, among the intractable cases there is a seemingly large variance in complexity, which cannot be explained by the classical algebraic approach using polymorphisms. In this contribution we will survey an alternative approach based on partial polymorphisms, which is useful for studying the fine-grained complexity of NP-complete CSPs. Moreover, we will state some challenging open problems in the research field.