There exist different types or genres of design science research (DSR) in information systems, like laboratory-oriented and practice-oriented DSR. This paper investigates arguments for a practice-oriented approach to DSR. It uses the research approach of practice research as a starting point to elaborate on a practice-oriented DSR approach we label Practice Design Research (PDR). In doing so, we address two unresolved issues in IS DSR: Theorizing and evaluation. PDR consists of two inter-related sub-activities: theorizing and situational design inquiry. The conduct of situational design inquiry is described as iterative cycles of (1) pre-evaluate, (2) plan & design, (3) test & intervene and (4) post-evaluate. We justify the foundations of these iterative sub-activities/cycles through a theoretically informed argument based on pragmatist philosophy and practice theory.