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Development of integrated electrochemical–quartz crystal microbalance biosensor arrays: towards ultrasensitive, multiplexed and rapid point-of-care dengue detection
International Islamic University Malaysia, Kuala Lumpur, Malaysia.
International Islamic University Malaysia, Kuala Lumpur, Malaysia.
International Islamic University Malaysia, Kuala Lumpur, Malaysia.
International Islamic University Malaysia, Kuala Lumpur, Malaysia.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - BIODEVICES 2019 / [ed] Ana Roque; Ana Fred; Hugo Gamboa, SciTePress, 2019, Vol. 1, s. 220-227Konferansepaper, Publicerat paper (Fagfellevurdert)
Abstract [en]

Dengue is an infectious mosquito-borne viral disease that affects approximately 50 million people annually worldwide and is prevalent mostly in the tropics. Severe cases of dengue can be fatal, making early detection and fast diagnosis crucial towards improving patient care and survival rates. Currently, early detection can be achieved through detection of NS1 protein, using ELISA technique. Unfortunately, ELISA is an expensive method, making it unsuitable as a screening technique, especially in low-resource settings. In this work, we present a prototype device and its early validation studies, of an integrated electrochemical and mass-sensor for dengue NS1 antigen. The sensor is connected to open source mass-sensing software and hardware, OpenQCM which makes it easily portable. Having dual-measurement capabilities (mass and impedance) increases the sensitivity of the sensor. Preliminary studies suggest that the prototype could achieve ultralow limit of detection as low as 10 ng mL-1, dual-sensing cross-validation capability, portable size, time of less than 30 minutes, and parallelization of multiple assays. This work could lead to early and accurate dengue detection in routine point-of-care settings.

sted, utgiver, år, opplag, sider
SciTePress, 2019. Vol. 1, s. 220-227
Serie
Biostec, ISSN 2184-4305
Emneord [en]
Dengue; Biosensor; Sensor Arrays; Integrated Electrochemical-Quartz Crystal Microbalance; Point-of-Care Diagnostics
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-165698DOI: 10.5220/0007523802200227ISI: 000671845700026Scopus ID: 2-s2.0-85064638905ISBN: 9789897583537 (tryckt)OAI: oai:DiVA.org:liu-165698DiVA, id: diva2:1430062
Konferanse
BioDevices, February 22-24, 2019, Prague, Czech Republic
Tilgjengelig fra: 2020-05-13 Laget: 2020-05-13 Sist oppdatert: 2024-09-01bibliografisk kontrollert

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