Introduction:Arrhythmogenic right ventricular cardiomyopathy (ARVC) causes fibro-fatty substitution of the myocardium in the right ventricle (RV). Cardiovascular magnetic resonance imaging (CMR) is the gold standard for visualization and volume quantification of the RV, but the assessment of wall motion, is still based on qualitative “eye-balling”. Previous studies have shown the successful application of feature tracking (CMR-FT) to the left ventricle. The aim of this study was to test the feasibility of CMR-FT to assess RV strain in patients (P) with ARVC and in healthy controls(C).Methods: Thirteen patients fulfilling Task Force Criteria for ARVC and twenty healthy subjects underwent cardiac MRI at 1,5 Tesla. Steady-state free precession cine of six long axis slices was acquired by rotating the cut planes around the long axis of the RV. The 3-, 4- and 2-chamber views of the RV were identified. Segmental longitudinal strain was measured and re-calculated in terms of regional strain for the base (B), mid (M) and apical (A) levels of the RV and for the anterior, inferior, septal and free walls. Results: RV end systolic volume was significantly higher and ejection fraction lower in patients (104-82 ml, 49- 56%).  Longitudinal strain decreased from base to apex in both groups (P:-25%, -22%, -19%, C:-31%, -24%, -20%). In a wall based analysis, the absolute strain values were significantly lower in patient lateral (P-24%, C -32%) and anterior walls (P -22%, C-28 %) but not in inferior (P-26%, C -27%) and septal walls (P -15%, C -18%). Conclusion: Feature tracking was successfully applied to the RV in this cohort of ARVC patients. Longitudinal absolute strain was lower in the basal segments, the anterior and the free walls compared to controls. This supports previous reports on the uneven regional distribution of ARVC.