Objective: This study aimed to investigate the effectiveness of percutaneous cholecystostomy (PC) as a step treatment in patients who underwent PC for acute cholecystitis. Methods: Data of 248 patients who underwent PC for acute cholecystitis between January 2015 and December 2019 were retrospectively analyzed. All patients who underwent PC were evaluated for a distal transition by cholangiography taken by the interventional radiology department in the third week after discharge. In addition, all patients were re-evaluated by the anesthesia department. Patients were retrospectively evaluated in terms of age, gender, American Society of Anesthesiologists physical status (ASA-PS) class, surgical procedure, complications after PC, and termination of PC. Results: A total of 231 patients were included in the study. The mean age of patients was 68.6 (minimum-maximum: 32-92 years) and the male/ female ratio was 1.04. The anesthesia evaluation of the patients categorized 44 patients (19.05%) as ASA-PS class I-II and 187 (80.95%) as ASAPS III-IV. A total of 17 (7.35%) patients died in the 30-day follow-up period. The examination of the remaining patient revealed that PC was used as a step treatment in the transition to elective cholecystostomy in 106 (45.8%) patients, whereas 108 (50.4%) had it as a final treatment method since an operation is impossible. The median follow-up period in these patients was 2.6 years. Recurrent cholecystitis developed in 14 (12.96%) patients in the group who underwent PC. Conclusion: PC should be noted as an alternative step treatment method for acute cholecystitis but maybe a final treatment option in patients with high comorbidity.