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The FTO rs9939609 “A” allele is associated with impaired fasting glucose and insulin resistance in Emirati population
College of Medicine, Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates; College of Medicine, Cairo University, Egypt.ORCID-id: 0000-0002-9287-7621
College of Medicine, Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates.
College of Medicine, Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates; College of Medicine, Suez Canal University, Egypt .ORCID-id: 0000-0002-0463-1518
College of Medicine, University of Sharjah, United Arab Emirates.
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2019 (engelsk)Inngår i: Gene, ISSN 0378-1119, E-ISSN 1879-0038, Vol. 681, s. 93-98Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Fat mass and obesity-associated protein gene variants have shown diverse influence on body weight and metabolism across different populations. Overweight, obesity and metabolic syndrome are multifactorial major health problems in the UAE and worldwide. Insulin resistance represents the link between overweight and development of metabolic syndrome and type 2 diabetes mellitus. We investigated two (FTO) variants in Emirati population, in relation to insulin resistance and different parameters of metabolic syndrome.

Methods: We recruited 259 Emiratis through the UAE National Diabetes and Lifestyle Project. Ethical approval was obtained. Besides basic data collection, venous blood samples were collected. Fasting blood glucose, Lipid profile, and insulin levels were measured. Genotyping for (FTO) rs9939609 (A>T) and rs9930506 (G>A) were performed using real time-PCR. Insulin resistance were identified using HOMA2-IR calculation; with a cut-off point of 1.4 for female and 1.18 for male subjects.

Results: The study included 259 Emiratis (age range 30-53 years, mean 41.76 years, 54.4% females), 24.5% are diabetic and 30.8% are hypertensive, with body mass index of 28.4 ± 5.9 and 28.7 ± 5.7 kg/m2 in female and male subjects, respectively. Homozygous A of rs9939609 showed significantly higher fasting glucose compared to other genotypes (p = 0.04) with a trend of higher insulin level and HOMA-2IR. The A/A diabetic patients (n = 13) showed significantly higher insulin levels compared to other genotypes. G allele of rs9930506 showed a trend of higher fasting glucose and HOMA-2IR, but lower insulin level and HbA1c. No association of genotypes was detected with other components of metabolic syndrome.

Conclusion: There is an association of FTO rs9939609 A/A genotype and impaired fasting glucose and insulin resistance. Homozygous A genotype diabetic patients may be more vulnerable to blood glucose fluctuation. Focused genotyping can help the health care providers to identify high risk groups of both normal population and diabetic patients to intervene accordingly.

sted, utgiver, år, opplag, sider
Elsevier, 2019. Vol. 681, s. 93-98
Emneord [en]
Diabetes mellitus; Emirati population; FTO; Fat mass and obesity-associated protein gene; HOMA; Insulin resistance; Metabolic syndrome; Obesity; Overweight; rs9930506; rs9939609
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Identifikatorer
URN: urn:nbn:se:liu:diva-184210DOI: 10.1016/j.gene.2018.09.053ISI: 000449894700013PubMedID: 30273662Scopus ID: 2-s2.0-85054269980OAI: oai:DiVA.org:liu-184210DiVA, id: diva2:1650551
Tilgjengelig fra: 2022-04-07 Laget: 2022-04-07 Sist oppdatert: 2022-04-14bibliografisk kontrollert

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