Biomechanical factors are evolutionary developed, neurobiological predispositions, which enables an individual to act in the world. Macrosocial factors are macrosocially relevant practices in a social setting like a community. Biomechanical and macrosocial factors are seen as dialectically constituted in action. This kind of thinking is outlined in a theoretical perspective I call the Activity Domain Theory. This volume is a collection of papers, which try to positioned the Activity Domain Theory on the boundary between information systems, neurobiology, and Integrationism – a new development in the theory of communication emerging from the work of a group of linguists at Oxford during the 1980s