In this study, a developed co-simulation method, which couples 1D-fluid and 3D-structural models, has been utilised to simulate wear in a hydraulic percussion unit. The effect of wear is generally detrimental on performance and lifetime for such units, but can also cause catastrophic failure and breakdown, requiring a total overhaul and replacement of core components. One experiment of standard straight impact was performed to investigate the tolerance against seizure. The percussion unit was operated at successively increasing operating pressures, and the level of wear was registered at each step, until seizure occurred. The co-simulation model was used to replicate the running conditions from the experiment to simulate the structural response to be used as input for the wear routine to calculate the wear depth. The wear pattern from the simulations corresponds well to the wear pattern from the experiment. Further, the effect of a misaligned impact on wear development was also studied, as this is a loading situation that typically occurs for hydraulic percussion units. The study demonstrates that the simulation method used has a potential for simulating wear and predicting seizure in hydraulic percussion units.