In a context of intense airport and airline competition, a few European airports have recently started offering self-connection services to price-sensitive holiday passengers travelling with a combination of tickets where the airline/s involved do not handle the transfer themselves. This paper provides an exploratory analysis of the potential and implications of self-connectivity for European airports and airlines using a case study of air travel routes to holiday destinations in the Mediterranean. With the help of a forecasting model based on a zero-inflated Poisson regression, we identify the airports and airlines that have the highest potential to facilitate self-connections in the selected markets. The results also explore some implications of the widespread development of self-connection services in Europe.