Stable and precise temperature control can effectively improve the engines fuel consumption and emissions. An advanced engine thermal management system (AETMS) composed of electric actuators has great potential in increasing the temperature tracking control accuracy and decreasing the system energy consumption. Time -varying disturbance and pure time delay in the system make it challenging to harmoniously control multiple actuators to ensure efficient temperature tracking performance. In addition, a reasonable power distribution of the actuators is beneficial to reduce the parasitic energy consumption of the system and further improve the system efficiency. In this article, an adaptive optimization control strategy consisting of a state predictor, a disturbance estimator, an energy consumption optimization block and a state tracking controller is proposed for the temperature tracking and energy consumption optimization of AETMS. Experimental verification was performed on a range extender bench of an extended-range electric vehicle, and the results show that the system achieves high-precision temperature control and energy consumption near the theoretical optimal value under changing working conditions. The temperature steady-state error is within 0.3 oC, and the temperature adjustment time is within 100 s after the first overshoot.