liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Identification of potentially relevant metals for the etiology of autism by using a Bayesian multivariate approach for partially censored values
Linköpings universitet, Institutionen för datavetenskap, Statistik och maskininlärning. Linköpings universitet, Filosofiska fakulteten.ORCID-id: 0000-0003-2193-6003
Univ Sao Paulo, Brazil.
Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för barns och kvinnors hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Barn- och kvinnocentrum, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus.ORCID-id: 0000-0003-1695-5234
Vise andre og tillknytning
2023 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 13, nr 1, artikkel-id 12622Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Heavy metals are known to be able to cross the placental and blood brain barriers to affect critical neurodevelopmental processes in the fetus. We measured metal levels (Al, Cd, Hg, Li, Pb and Zn) in the cord blood of newborns and in the serum of the same children at 5 years of age, and compared between individuals with or without (controls) autism spectrum disorder (ASD) diagnosis. The samples were from a biobank associated with the All Babies in Southeast Sweden (ABIS) registry. We proposed a Bayesian multivariate log-normal model for partially censored values to identify potentially relevant metals for the etiology of ASD. Our results in cord blood suggest prenatal Al levels could be indicative of later ASD incidence, which could also be related to an increased possibility of a high, potentially toxic, exposure to Al and Li during pregnancy. In addition, a larger possibility of a high, potentially beneficial, exposure to Zn could occur during pregnancy in controls. Finally, we found decisive evidence for an average increase of Hg in 5-year-old ASD children compared to only weak evidence for controls. This is concordant with previous research showing an impaired ability for eliminating Hg in the ASD group.

sted, utgiver, år, opplag, sider
NATURE PORTFOLIO , 2023. Vol. 13, nr 1, artikkel-id 12622
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-197082DOI: 10.1038/s41598-023-38780-9ISI: 001042854100016PubMedID: 37537167Scopus ID: 2-s2.0-85166585539OAI: oai:DiVA.org:liu-197082DiVA, id: diva2:1790296
Forskningsfinansiär
Linköpings universitet
Merknad

Funding: Faculty of Arts and Sciences at Linkouml;ping University, Sweden; Escher Fund for Autism; Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS); Barndiabetesfonden (Swedish Child Diabetes Foundation); Swedish Council for Working Life and Social Research [FAS20041775, K2005-72X-11242-11A]; Swedish Research Council [K2008-69X-20826-01-4, K 98-99D-12813-01A]; Medical Research Council of Southeast Sweden (FORSS); JDRF Wallenberg Foundation [2018-01074]; OEstgoeta Brandstodsbolag; Region OEstergoetland; Linkoeping university, Sweden; Joanna Cocozza Foundation; Linkoeping University;  [FAS2004-1775]

Tilgjengelig fra: 2023-08-22 Laget: 2023-08-22 Sist oppdatert: 2025-02-06

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Wegmann, BertilLudvigsson, Johnny

Søk i DiVA

Av forfatter/redaktør
Wegmann, BertilMiemczyk, StefanLudvigsson, Johnny
Av organisasjonen
I samme tidsskrift
Scientific Reports

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 148 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf