This introductory chapter sheds light on the opportunities and challenges that the digital era has in store for the European Union (EU) at a time when its fundamental values are being called into question by prominent political currents. The chapter sets the scene by an account of how previous periods of technological transformation affected European societies and considers the financial and regulatory resources at the disposal of the EU to manage the technological shift of the 2020s. The chapter introduces the book’s interdisciplinary approach, which offers various disciplinary perspectives on how the technological mega-shift impacts the EU’s ability to meet the multifaceted challenges it is facing. The chapter concludes that decision-makers at the national as well as European levels must be prepared to take a holistic perspective when addressing technological trends and seeking solutions to the problems that arise in the wake of changing economic and political conditions in society.