There is an alarming rise/increase of older people in EUs population, with an expected percentage of people over 65 at 30% by 2060, and the majority of older workers willing to work past their traditional retirement age. The concept of Work Ability, which has been developed as an important multi-factor concept that can be used to identify workers at risk for an imbalance between health, personal resources and work demands, has the potential to mitigate the decrease in work ability of office workers while aging. The framework for modeling the work ability of the office worker, described at a conceptual level in this work, is grounded in a holistic multidimensional model which accounts for both the cognitive and physical resources of the individual, and factors related to work and the environment outside of work. AI tools for prediction and risk assessment allow for dimension specific decision support and intervention, including on-the-fly flexible work management, coping with stress at work, and on-demand training.