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Revisiting Salerno's sine-Gordon model of DNA: Active regions and robustness
Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för fysik, kemi och biologi.
Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för teknik och naturvetenskap.ORCID-id: 0000-0003-0528-9782
2003 (engelsk)Inngår i: Physica D: Non-linear phenomena, ISSN 0167-2789, E-ISSN 1872-8022, Vol. 177, nr 1-4, s. 233-241Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We return to a simple model of DNA-transcription, first investigated by Salerno more than 10 years ago. One conjecture that time was that the promoter-regions were "dynamically active" in the sense that a stationary kink solution to the discrete sine-Gordon equation spontaneously starts to move when positioned in certain regions. Here we explore the whole genome of the bacteriophage T7, which is the same that was used in the first studies. We find that the regions in the promoters where the DNA-binding molecules attach have no special significance, while the start of the RNA-coding regions are dynamically active on a significant level. The results are checked to be robust by imposing an external disturbance in the form of a thermostat, simulating a constant temperature. © 2002 Elsevier Science B.V. All rights reserved.

sted, utgiver, år, opplag, sider
2003. Vol. 177, nr 1-4, s. 233-241
Emneord [en]
DNA, Genome-wide, Promoters, Robustness, Sine-Gordon
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-46698DOI: 10.1016/S0167-2789(02)00769-8OAI: oai:DiVA.org:liu-46698DiVA, id: diva2:267594
Tilgjengelig fra: 2009-10-11 Laget: 2009-10-11 Sist oppdatert: 2017-12-13

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Lennholm, ErikHörnquist, Michael

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