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Quality of life after orthognathic surgery and orthognathic aspects on respiratory function during sleep
Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för kirurgi, ortopedi och onkologi. Linköpings universitet, Medicinska fakulteten.ORCID-id: 0000-0003-2102-0919
2026 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Orthognathic surgery is frequently used to correct dentofacial deformities (DFDs) in skeletally mature, non-growing individuals and has a history spanning over more than 150 years. Despite previous research, questions remain about how this treatment affects the patient’s quality of life, upper airways, and respiratory function.

The overall aim of this PhD thesis was to achieve a greater understanding of how orthognathic surgery affects patients’ quality of life in a Swedish context, with additional aspects regarding upper airway function and breathing.

The thesis comprises four studies.

In Study I, the recommended guidelines were used to translate the English-language Orthognathic Quality of Life Questionnaire (OQLQ) into Swedish (OQLQ-S). A group of 121 patients in four diagnostic groups participated in reliability and validity evaluations of the translated Swedish version of the instrument. The main conclusion was that the data supported the OQLQ-S’s validity, reliability, and comparability with the original English version.

Studies II and IV were prospective longitudinal studies of 62 consecutive patients undergoing orthognathic surgery for aesthetic and functional indications. In Study II, respiratory function was assessed using home cardiorespiratory polygraphy on three occasions: prior to orthognathic surgery and at 3 months and 1 year after surgery. None of the patients had previously been diagnosed with obstructive sleep apnoea (OSA). Surgical displacements were evaluated based on measurements in three dimensions using pre- and postoperative computed tomography. There were only minor changes in respiratory parameters such as the apnoea–hypopnoea index (AHI), the apnoea–hypopnoea index in the supine and non-supine positions, the oxygen saturation index (ODI), and the snore index. There was no significant correlation between surgical displacement and AHI, supine AHI, non-supine AHI, and ODI. There was a weak but significant correlation between vertical displacement of the anterior mandible and the snore index. The main conclusion was that the risk for iatrogenic obstruction of the upper airways seemed low in patients without OSA treated with orthognathic surgery.

In Study IV, oral health-related quality of life (OHRQoL) was evaluated with four questionnaires – OQLQ-S, Oral Health Impact 14 (OHIP-14), the Jaw Function Limitation Scale (JFLS), and the Oral Esthetic Scale (OES) – both before and after surgery and in comparison, to a control group comprising 31 patients without DFDs. On average, DFD subjects who underwent orthognathic surgery reported improvements across all scales and subscales, indicating that the surgery was beneficial. At baseline, the DFD group rated their OHRQoL significantly lower than the control group, but this difference levelled out at follow-up. However, some patients reported unchanged or worse outcomes on some of the instruments’ subscales, mainly decreased jaw mobility and an increased postoperative score in the psychosocial impact domain. The main conclusion was that orthognathic surgery has a positive impact on OHRQoL in DFD subjects.

Study III was a retrospective study of 165 adult OSA patients treated with a mandibular advancement device (MAD). Data on AHI, supine sleep, age, sex, body mass index (BMI), Epworth Sleepiness Scale (ESS) scores, mandibular protrusion, patient-reported use, and adverse effects of the MAD were retrospectively collected from medical records or the Swedish Sleep Apnoea Register. Among the included patients, 27.3% (45/165) had both positional OSA at baseline and a ≥50% difference in the proportions of supine sleep between baseline and follow-up. A generalised linear model indicated that changes in the proportion of supine sleep time had a statistically significant effect on the change in overall AHI from baseline to follow-up, comparable in magnitude to the effect of the MAD. The main conclusion was that changes in the proportion of supine sleep are an important determinant of changes between measurements in overall AHI in many patients treated with MADs. Positional OSA must be acknowledged not only in OSA diagnostics but also in MAD treatment follow-up.

Ort, förlag, år, upplaga, sidor
Linköping: Linköping University Electronic Press, 2026. , s. 94
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 2024
Nyckelord [en]
Surveys and questionnaires, Dentofacial deformities, Orthognathic surgery, Quality of life, Airway obstruction, Sleep apnoea
Nationell ämneskategori
Odontologi
Identifikatorer
URN: urn:nbn:se:liu:diva-222411DOI: 10.3384/9789181184044ISBN: 9789181184037 (tryckt)ISBN: 9789181184044 (digital)OAI: oai:DiVA.org:liu-222411DiVA, id: diva2:2049811
Disputation
2026-05-08, Aulan, Länssjukhuset Ryhov, Jönköping, 13:00 (Svenska)
Opponent
Handledare
Anmärkning

Funding: The research was supported by grants from Futurum, the Academy for Healthcare, Jönköping County Council and FORSS, the Research Council of South-Eastern Sweden.

Tillgänglig från: 2026-03-31 Skapad: 2026-03-31 Senast uppdaterad: 2026-04-20Bibliografiskt granskad
Delarbeten
1. Translation and validation of the English-language instrument Orthognathic Quality of Life Questionair into Swedish
Öppna denna publikation i ny flik eller fönster >>Translation and validation of the English-language instrument Orthognathic Quality of Life Questionair into Swedish
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2021 (Engelska)Ingår i: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 79, nr 1, s. 19-24Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: In orthognathic surgery, understanding the patients motives for treatment is a key factor for postoperative patient satisfaction and treatment success. In countries/systems where orthognathic surgery is funded by public means, patients are referred mainly due to functional problems, although studies of quality of life related changes after treatment indicate that psychosocial and aesthetic reasons might be equal or more important for the patient. There is no available validated condition specific instruments in the Swedish language for quality of life evaluation of patients with dentofacial deformities. Aims/objectives: Cross cultural translation and adaptation of the English-language instrument Orthognathic Quality of Life Questionnaire (OQLQ) into Swedish. Methods: OQLQ was translated into Swedish. A total of 121 patients in four groups were recruited and the Swedish version of the OQLQ (OQLQ-S) was tested by psychometric methods. Reliability was assessed by internal consistency and test-retest reliability. Validity was evaluated by face, convergent and discriminant validity. Results/findings and conclusions: OQLQ-S is reliable and showed good construct validity and internal consistency and can be used in a Swedish speaking population as a complement to clinical variables to evaluate patients with dentofacial deformity.

Ort, förlag, år, upplaga, sidor
TAYLOR & FRANCIS LTD, 2021
Nyckelord
Surveys and Questionnaires; Quality of Life; dentofacial deformities; orthognathic surgery
Nationell ämneskategori
Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi
Identifikatorer
urn:nbn:se:liu:diva-166918 (URN)10.1080/00016357.2020.1768284 (DOI)000537901500001 ()32432962 (PubMedID)
Anmärkning

Funding Agencies|research council FUTURUM, Region Jonkopings County, Sweden

Tillgänglig från: 2020-06-22 Skapad: 2020-06-22 Senast uppdaterad: 2026-03-31
2. Effects of orthognathic surgery on respiratory function during sleep: A prospective longitudinal study
Öppna denna publikation i ny flik eller fönster >>Effects of orthognathic surgery on respiratory function during sleep: A prospective longitudinal study
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2024 (Engelska)Ingår i: Orthodontics & craniofacial research, ISSN 1601-6335, E-ISSN 1601-6343, Vol. 27, nr 6, s. 877-885Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

When treating patients with orthognathic surgery, there might be a risk of obstructive sleep apnoea (OSA) due to soft tissue changes in the upper airways, especially in patients treated with isolated mandibular setback or mandibular setback in combination with maxillary advancement. In the present study, we assessed respiratory function during sleep with home cardiorespiratory polygraphy in 62 patients who had not been previously been diagnosed with OSA at three times: prior to orthognathic surgery for aesthetic and functional indications, and then 3 months and 1 year after surgery. We evaluated surgical displacement based on measurements in three dimensions using pre- and post-operative computed tomography. There were only minor changes in the respiratory parameters such as the apnoea-hypopnoea index (AHI), the apnoea-hypopnoea index in the supine position (AHIsup), the oxygen saturation index (ODI) and the snore index. There was no significant correlation between surgical displacement and the AHI, AHIsup and ODI. There was a weak but significant correlation between vertical displacement of the anterior mandible and the snore index. Within the limitations of the present study, the risk for iatrogenic obstruction of the upper airways seems to be low in patients without OSA treated with orthognathic surgery.

Ort, förlag, år, upplaga, sidor
WILEY, 2024
Nyckelord
airway obstruction; orthognathic surgery; sleep apnoea; snoring; tomography
Nationell ämneskategori
Anestesi och intensivvård
Identifikatorer
urn:nbn:se:liu:diva-206600 (URN)10.1111/ocr.12828 (DOI)001257160000001 ()38940200 (PubMedID)
Anmärkning

Funding Agencies|FORSS (The Research Council of South-Eastern Sweden) [FORSS-649201]; Futurum [FUTURUM-963632]; Interrater reliability of the CT scans; Futurum, Ryhov County Hospital

Tillgänglig från: 2024-08-21 Skapad: 2024-08-21 Senast uppdaterad: 2026-03-31
3. Positional obstructive sleep apnoea and supine sleep time in mandibular advancement device treatment
Öppna denna publikation i ny flik eller fönster >>Positional obstructive sleep apnoea and supine sleep time in mandibular advancement device treatment
2026 (Engelska)Ingår i: Sleep Science and Practice, E-ISSN 2398-2683, Vol. 10, nr 1, artikel-id 19Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background

Many patients have positional obstructive sleep apnoea (OSA) with an apnoea-hypopnoea index (AHI) that is two-fold higher in supine sleep than in non-supine sleep. In these patients, the proportion of time spent in supine sleep influences the overall AHI. With the example of OSA patients treated with a mandibular advancement device (MAD), the aim of this study was to test the hypothesis that between-measurement differences in the proportion of supine sleep time are a significant factor affecting changes in AHI.

Methods

One hundred sixty-five adult OSA patients treated with MAD were included in the study. Data on AHI, supine sleep time, age, sex, body mass index (BMI), Epworth Sleepiness Scale (ESS) scores, mandibular protrusion, patient-reported use, and adverse effects of the MAD were retrospectively collected from medical records or the Swedish Sleep Apnoea Register.

Results

Among included patients, 27.3% (45/165) had both positional OSA at baseline and a ≥ 50% difference in the proportions of supine sleep time between baseline and follow-up. A generalized linear model showed that changes in the proportion of supine sleep time had a statistically significant impact on the change in overall AHI from baseline to follow-up of similar size as the effect the MAD.

Conclusions

Changes in the proportion of supine sleep time are an important contributor to between -measurements changes in overall AHI in many patients treated with MAD. Positional OSA must be acknowledged not only in OSA diagnostics but also in MAD treatment follow-up.

Ort, förlag, år, upplaga, sidor
Springer Nature, 2026
Nyckelord
Bruxism; Dental patient assessment; Malocclusion; Orthodontics; Sleep Disorders; Temporomandibular disorders; Obstructive Sleep Apnea Diagnosis and Management
Nationell ämneskategori
Geriatrik
Identifikatorer
urn:nbn:se:liu:diva-223006 (URN)10.1186/s41606-026-00185-8 (DOI)
Forskningsfinansiär
Linköpings universitet
Tillgänglig från: 2026-04-20 Skapad: 2026-04-20 Senast uppdaterad: 2026-04-20

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