This paper addresses the problem of change detection for a quadcopter in the presence ofwind disturbances. Different aspects of the quadcopter dynamics and various flight conditions have beeninvestigated. First, the wind is modeled using the Dryden wind model as a sum of a low-frequent and aturbulent part. Since the closed-loop control can compensate for system changes and disturbances andthe effect of the wind disturbance is significant, the residuals obtained from a standard simulation modelcan be misleading. Instead, a sensor-to-sensor submodel of the quadcopter is selected to detect a changein the payload using the Instrumental Variables (IV) cost function. It is shown that the mass variationcan be detected using the IV cost function in different flight scenarios.