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Funding Agencies|Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [HD040364, HD042444, HD051997]; Special Statutory Funding Program for Type 1 Diabetes Research; National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA; Canadian Institutes of Health ResearchCanadian Institutes of Health Research (CIHR); Juvenile Diabetes Research Foundation InternationalJuvenile Diabetes Research Foundation; Commission of the European Communities (specific RTD programme "Quality of Life and Management of Living Resources) [QLK1-2002-00372]; European Foundation for the Study of Diabetes/JDRF/Novo Nordisk Focused Research Grant; Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research)Academy of Finland [250114]; Dutch Diabetes Research Foundation; Finnish Diabetes Research Foundation