A wealth of contemporary speculative practices on how to deal with life, death, and co-existence on a planet haunted by pandemics, mass species extinctions, climate change, and rampant societal injustice are currently circulating, in public — in academia, in art, and in activism. Existential concerns, what the humanities are well-equipped to handle, and new insights are sought after in public. So how can the humanities respond well? For instance to the normative notions of the human that make some people more killable than others (like the elderly COVID-patients in Swedish nursing homes, black men in the US, born or unborn girls in very poor communities, refugees in camps, indigenous environmental activists in the global South). How can the humanities make themselves, to use a term from Donna Haraway, respons-able for how a ‘normative human’ has also shaped the planet into such an inhabitable or even toxic place for many others? One answer, a well-trodden path by now, are the feminist posthumanities, and how they together (as environmental humanities, medical humanities, decolonial humanities, queer humanities, technohumanities, posthuman or multispecies humanities) question the exclusions and inclusions made in the name of the human and the humanities. Here theory meets practice, science meets art, and a transformational sense of humanity meets the people.