Machine learning (ML) techniques in association to emerging sixth generation (6G) technologies, i.e., massive Internet of Things (IoT), big data analytics have caught too much attention from academia to the business world since last few years due to their high and fast computing capabilities. The role of ML-based 6G techniques is to reshape the imaginary idea into physical world for resolving the challenging issues of energy, quality of service (QoS), and quality of experience (QoE). Besides, ML techniques with better association to 6G reshapes the industrial network in box (NIB) platform. In the mean-time rapidly increasing market of the IoT devices to deliver multimedia content has caught the attention of various fields such as, industrial, and healthcare. The challenging issue that end-users are facing is the unsatisfactory and annoyed performance of portable devices while surfing the video, and image to/from desired entity, i.e., low QoE. To resolve these issues this research first, proposes a novel ML-driven mobility management method for the efficient communication in industrial NIB applications. Second, a novel architecture of 6G-based intelligent QoE and QoS optimization in industrial NIB is proposed. Third, a 6G-based NIB framework is proposed in association to the long-term evolution. Forth, use-case for 6G-empowered industrial NIB is recommended for an energy efficient communication. Experimental results are extracted with high energy efficiency, better QoE, and QoS in 6G-based industrial NIB.