Purpose - Technology-enabled business-to-business (B2B) services contribute the largest share to GDP growth and are fundamental for an economy's value creation. This article aims to identify key service- and digital technology-driven B2B innovation modes and proposes a research agenda for further exploration.Design/methodology/approach - This conceptual paper adopts a techno-demarcation view on service innovation, encompassing three core dimensions: service offering (the service product, or the "what"), service process (the "how") and service ecosystem (the "who/for whom"). It delineates the implications of three digital technologies - the internet-of-things (IoT), intelligent automation (IA) and digital platforms - for service innovation across these core dimensions in B2B markets.Findings - Digital technology has immense potential ramifications for value creation by reshaping all three core dimensions of service innovation. Specifically, IoT can transform physical resources into reconfigurable service products, IA can augment and automate a rapidly expanding array of service processes, while digital platforms provide the technical and organizational infrastructure for the integration of resources and stakeholders within service ecosystems.Originality/value - This study suggests an agenda with six themes for further research, each linked to one or more of the three service innovation dimensions. They are (1) new recurring revenue models, (2) service innovation in the metaverse, (3) scaling up service innovations, (4) ecosystem innovations, (5) power dependency and lock-in effects and (6) security and responsibility in digital domains.