To be competitive, it is widely recognized that manufacturing companies need attention on sustainability aspects. However, there is still a lack of knowledge about how to combine requirements on sustainability and profitability to achieve long-term competitive manufacturing. Furthermore, there is a need for knowledge on how to develop resilient and sustainable production systems. This paper aims to explore the state-of-the art and state-of-practice associated with development of resilient and sustainable production systems, with focus on challenges and enablers. To achieve the aim of the paper, a traditional literature review was carried out, combined with results from knowledge creation workshops with five manufacturing companies striving towards resilient and sustainable production systems. In the paper, initial results from a three-year research project are included. The research project aims at developing knowledge that can support development of resilient and sustainable production systems, including the value chain, for the future. The industrial relevance of the project lies in ensuring a future-proof adaptable factory in an efficient industrial value chain, based on circularity in terms of minimum waste and long-term overall sustainability with a triple bottom line perspective, including social, ecological, and long-term economic values.