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Therapeutic potential of human umbilical cord derived mesenchymal stem cells on rat model of liver fibrosis
Suez Canal Univ, Egypt.
Suez Canal Univ, Egypt; Badr Univ Cairo, Egypt.
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Suez Canal Univ, Egypt.ORCID iD: 0000-0002-0463-1518
Suez Canal Univ, Egypt.
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2019 (English)In: American Journal of Stem Cells, ISSN 2160-4150, Vol. 8, no 1Article in journal (Refereed) Published
Abstract [en]

End-stage liver disease is a worldwide cause of morbidity and mortality, which is associated with a considerable economic burden. As the disease progresses, fibrosis will replace the hepatic architecture and compromise liver functions. The regenerative approach for the injured liver can provide a hope for these patients; however, it is still facing many challenges. In the current study, we aimed at (1) assessing hepatic regenerative capacity of mesenchymal stem cells, isolated from human umbilical cord blood (HMSCs), in a rat model of carbon-tetrachloride (CCL4) induced liver fibrosis, (2) comparing the therapeutic effects with other cell populations derived from umbilical cord blood and (3) evaluating the host response to the human-derived cells. Fifteen rats received either the whole mononuclear cell fraction (HMNCs), CD34-ve subpopulation or HMSCs. A fourth group did not receive any treatment and another group was left without induction of fibrosis as positive and negative controls. All groups that received cellular treatment showed homing of the human cells and improvement of the liver architecture and functional capacity. The groups received CD34-ve cells and HMSCs had the most efficient improvement in liver functions, microscopic regenerative markers and histological appearance while the least immune reaction was noted with HMSCs. HUCB-MSCs showed significant immunemodulatory effect on rat immune cells. This study can provide a clue about a simple and effective method for the management of fibrotic liver diseases.

Place, publisher, year, edition, pages
E-CENTURY PUBLISHING CORP , 2019. Vol. 8, no 1
Keywords [en]
Mesenchymal stem cells; CD34-ve cells; hepatic regeneration; liver fibrosis; immune response; cell therapy
National Category
Immunology
Identifiers
URN: urn:nbn:se:liu:diva-164505ISI: 000468128600002OAI: oai:DiVA.org:liu-164505DiVA, id: diva2:1416443
Available from: 2020-03-23 Created: 2020-03-23 Last updated: 2022-03-25Bibliographically approved

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El-Serafi, Ahmed Taher

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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health Sciences
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