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Vascularization is the next challenge for skin tissue engineering as a solution for burn management
Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery. MSA University, Egypt.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.ORCID iD: 0000-0002-8027-9632
Linköping University, Department of Biomedical and Clinical Sciences, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.ORCID iD: 0000-0002-5903-2918
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2020 (English)In: Burns & trauma, ISSN 2321-3868, Vol. 8, article id tkaa022Article, review/survey (Refereed) Published
Abstract [en]

Skin regeneration represents a promising line of management for patients with skin loss, including burn victims. The current approach of spraying single cells over the defective areas results in variable success rates in different centers. The modern approach is to synthesize a multilayer skin construct that is based on autologous stem cells. One of the main complications with different types of transplants is sloughing due to the absence of proper vascularization. Ensuring proper vascularization will be crucial for the integration of skin constructs with the surrounding tissues. Combination of the right cells with scaffolds of proper physico-chemical properties, vascularization can be markedly enhanced. The material effect, pore size and adsorption of certain proteins, as well as the application of appropriate growth factors, such as vascular endothelial growth factors, can have an additive effect. A selection of the most effective protocols is discussed in this review.

Place, publisher, year, edition, pages
Oxford University Press, 2020. Vol. 8, article id tkaa022
Keywords [en]
Burn; Regeneration; Skin; Tissue engineering; Vascularization
National Category
Cell and Molecular Biology Surgery
Identifiers
URN: urn:nbn:se:liu:diva-168493DOI: 10.1093/burnst/tkaa022ISI: 000562483300001PubMedID: 32766342OAI: oai:DiVA.org:liu-168493DiVA, id: diva2:1460836
Available from: 2020-08-25 Created: 2020-08-25 Last updated: 2022-03-25Bibliographically approved

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Shahin, HadyElmasry, MoustafaSteinvall, IngridSjöberg, FolkeEl-Serafi, Ahmed Taher

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Shahin, HadyElmasry, MoustafaSteinvall, IngridSjöberg, FolkeEl-Serafi, Ahmed Taher
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Hand and Plastic Surgery
Cell and Molecular BiologySurgery

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