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Magnetic resonance assessment of effective confinement anisotropy with orientationally-averaged single and double diffusion encoding
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0002-0722-9161
Linköping University, Department of Mathematics, Mathematics and Applied Mathematics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-9045-0889
Harvard Medical School, USA.
Linköping University, Department of Biomedical Engineering, Division of Biomedical Engineering. Linköping University, Faculty of Science & Engineering. Linköping University, Center for Medical Image Science and Visualization (CMIV).
2021 (English)In: Anisotropy across fields and scales / [ed] Evren Özarslan,Thomas Schultz, Eugene Zhang, Andrea Fuster, Springer, 2021, p. 203-223Chapter in book (Refereed)
Abstract [en]

Porous or biological materials comprise a multitude of micro-domainscontaining water. Diffusion-weighted magnetic resonance measurements are sensitive to the anisotropy of the thermal motion of such water. This anisotropy can bedue to the domain shape, as well as the (lack of) dispersion in their orientations.Averaging over measurements that span all orientations is a trick to suppress thelatter, thereby untangling it from the influence of the domains’ anisotropy on thesignal. Here, we consider domains whose anisotropy is modeled as being the resultof a Hookean (spring) force, which has the advantage of having a Gaussian diffusionpropagator while still confining the spatial range for the diffusing particles. In fact,this confinement model is the effective model of restricted diffusion when diffusion isencoded via gradients of long durations, making the model relevant to a broad rangeof studies aiming to characterize porous media with microscopic subdomains. In thisstudy, analytical expressions for the powder-averaged signal under this assumptionare given for so-called single and double diffusion encoding schemes, which sensitize the MR signal to the diffusive displacement of particles in, respectively, one ortwo consecutive time intervals. The signal for one-dimensional diffusion is shownto exhibit power-law dependence on the gradient strength while its coefficient bearssignatures of restricted diffusion.

Place, publisher, year, edition, pages
Springer, 2021. p. 203-223
Series
Mathematics and Visualization, ISSN 1612-3786, E-ISSN 2197-666X
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:liu:diva-173660DOI: 10.1007/978-3-030-56215-1_10Libris ID: hv7c7dtgf1vh9w0fISBN: 9783030562144 (print)ISBN: 9783030562151 (electronic)OAI: oai:DiVA.org:liu-173660DiVA, id: diva2:1532386
Note

Funding agencies: : Swedish Foundation for Strategic Research AM13-0090, the Swedish Research Council 2016-04482, Linköping University Center for Industrial Information Technology (CENIIT), VINNOVA/ITEA3 17021 IMPACT, and National Institutes of Health P41EB015902 and R01MH074794. 

Available from: 2021-03-01 Created: 2021-03-01 Last updated: 2024-01-10Bibliographically approved

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Publisher's full texthttps://libris.kb.se/bib/hv7c7dtgf1vh9w0f

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Yolcu, CemHerberthson, MagnusÖzarslan, Evren

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Yolcu, CemHerberthson, MagnusÖzarslan, Evren
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Division of Biomedical EngineeringFaculty of Science & EngineeringMathematics and Applied MathematicsCenter for Medical Image Science and Visualization (CMIV)
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CiteExportLink to record
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Citation style
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