liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Coenzyme Q(10) supplementation - In ageing and disease
Innlandet Hosp Trust, Norway.
Norwegian Inst Publ Hlth, Norway.
Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för diagnostik och specialistmedicin. Linköpings universitet, Medicinska fakulteten.
2021 (Engelska)Ingår i: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 197, artikel-id 111521Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Coenzyme Q(10) (CoQ(10)) is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells produce CoQ(10) by a specialized cytoplasmatic-mitochondrial pathway. CoQ(10) deficiency can result from genetic failure or ageing. Some drugs including statins, widely used by inter alia elderly, may inhibit endogenous CoQ(10) synthesis. There are also chronic diseases with lower levels of CoQ(10) in tissues and organs. High doses of CoQ(10) may increase both circulating and intracellular levels, but there are conflicting results regarding bioavailability. Here, we review the current knowledge of CoQ(10) biosynthesis and primary and acquired CoQ(10) deficiency, and results from clinical trials based on CoQ(10) supplementation. There are indications that supplementation positively affects mitochondrial deficiency syndrome and some of the symptoms of ageing. Cardiovascular disease and inflammation appear to be alleviated by the antioxidant effect of CoQ(10). There is a need for further studies and well-designed clinical trials, with CoQ(10) in a formulation of proven bioavailability, involving a greater number of participants undergoing longer treatments in order to assess the benefits of CoQ(10) treatment in neurodegenerative disorders, as well as in metabolic syndrome and its complications.

Ort, förlag, år, upplaga, sidor
Elsevier Ireland Ltd , 2021. Vol. 197, artikel-id 111521
Nyckelord [en]
Coenzyme Q(10); Physiological function; Ageing; Cardiovascular disease; Neurodegenerative disease
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:liu:diva-179940DOI: 10.1016/j.mad.2021.111521ISI: 000668514900002PubMedID: 34129891OAI: oai:DiVA.org:liu-179940DiVA, id: diva2:1601511
Anmärkning

Funding Agencies|Norwegian Institute of Public Health, Norway; Innlandet Hospital Trust, Norway

Tillgänglig från: 2021-10-08 Skapad: 2021-10-08 Senast uppdaterad: 2022-05-23

Open Access i DiVA

fulltext(1257 kB)582 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1257 kBChecksumma SHA-512
7a8d7a4b0cec40e3de1c5f856376df9cce577841f2245b539ccbd7ef2387615d00a8ca416357a99d0db48c9d791b3bf3824b869c2a1867ee86839d9aa9d8dfdd
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Sök vidare i DiVA

Av författaren/redaktören
Alehagen, Urban
Av organisationen
Avdelningen för diagnostik och specialistmedicinMedicinska fakulteten
I samma tidskrift
Mechanisms of Ageing and Development
Neurologi

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 583 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 267 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf